Patents Issued in September 15, 1987
  • Patent number: 4692459
    Abstract: Inhibitors of angiotensin converting enzyme which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl;A is L-phenylalanyl, D-phenylalanyl, D,L-alanyl, D-alanyl, D,L-tryptophyl, D-tryptophyl, D,L-tyrosyl, D-tyrosyl, D,L-isoleucyl, D-isoleucyl, D,L-leucyl, D-leucyl, D,L-histidyl, D-histidyl, D,L-valyl, or D-valyl, the .alpha.-amino group thereof being in amide linkage with R;R.sub.1 is hydrogen or methyl;R.sub.2 is L-proline, L-3,4-dehydroproline, D,L-3,4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkage with the adjacent ##STR2## and, n is 0 or 1, such that when n is 0, R.sub.1 is methyl are disclosed as useful anti-hypertensive agents.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: September 15, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Patent number: D291840
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: September 15, 1987
    Inventor: Lonny R. Cameron
  • Patent number: D291841
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: September 15, 1987
    Inventor: Betty Owens
  • Patent number: D291842
    Type: Grant
    Filed: October 2, 1984
    Date of Patent: September 15, 1987
    Inventor: Edward W. Baumgardner
  • Patent number: D291843
    Type: Grant
    Filed: October 19, 1984
    Date of Patent: September 15, 1987
    Inventor: Robert Searle
  • Patent number: D291844
    Type: Grant
    Filed: January 21, 1986
    Date of Patent: September 15, 1987
    Inventors: Julie Gerver, Howard Gerver
  • Patent number: D291845
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: September 15, 1987
    Inventor: Tonino Lamborghini
  • Patent number: D291846
    Type: Grant
    Filed: March 26, 1985
    Date of Patent: September 15, 1987
    Assignee: Mallin Company
    Inventor: Marks M. Conn
  • Patent number: D291847
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: September 15, 1987
    Assignee: Saporiti Italia, S.p.A.
    Inventor: Alberto Salvati
  • Patent number: D291848
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: September 15, 1987
    Inventor: Christian B. Cadman
  • Patent number: D291849
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: September 15, 1987
    Inventor: Raymond H. Yates
  • Patent number: D291850
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: September 15, 1987
    Inventors: Leonard L. Perkins, Anthony Perkins
  • Patent number: D291851
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: September 15, 1987
    Assignee: Saporiti Italia S.p.A.
    Inventor: Maurizio Salvato
  • Patent number: D291852
    Type: Grant
    Filed: March 26, 1985
    Date of Patent: September 15, 1987
    Assignee: Mallin Company
    Inventor: Marks M. Conn
  • Patent number: D291853
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: September 15, 1987
    Assignee: All-Steel Canada Ltd.
    Inventors: William R. Worrell, Robert N. Laroche
  • Patent number: D291854
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: September 15, 1987
    Assignee: Plastics, Inc.
    Inventors: James F. Pomroy, Allen M. Danley
  • Patent number: D291855
    Type: Grant
    Filed: December 4, 1984
    Date of Patent: September 15, 1987
    Assignee: Weber-Stephen Products Co.
    Inventors: Arthur R. Erbach, James C. Stephen
  • Patent number: D291856
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: September 15, 1987
    Assignee: American Commercial Inc.
    Inventor: Walter Everhan
  • Patent number: D291857
    Type: Grant
    Filed: August 13, 1984
    Date of Patent: September 15, 1987
    Inventor: Stewart C. Nelson
  • Patent number: D291858
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: September 15, 1987
    Assignee: John F. Baker
    Inventors: John F. Baker, Barry Dep
  • Patent number: D291859
    Type: Grant
    Filed: July 17, 1984
    Date of Patent: September 15, 1987
    Assignee: Rotpunkt Dr. Anso Zimmermann, Limited Partnership Industriestrasse
    Inventor: Anso Zimmermann
  • Patent number: D291860
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: September 15, 1987
    Assignee: Danro Engineering (Proprietary) Limited
    Inventors: Robert Wallace, Dragan Miskowic
  • Patent number: D291861
    Type: Grant
    Filed: April 20, 1984
    Date of Patent: September 15, 1987
    Inventor: Samuel C. Smith
  • Patent number: D291862
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: September 15, 1987
    Inventor: Robert A. Kolonia
  • Patent number: D291863
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: September 15, 1987
    Inventor: Robert A. Kolonia
  • Patent number: D291864
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: September 15, 1987
    Assignee: Micro Plastics, Inc.
    Inventor: Royce W. Hill
  • Patent number: D291865
    Type: Grant
    Filed: April 10, 1985
    Date of Patent: September 15, 1987
    Assignee: Kraft, Inc.
    Inventor: Michele A. Carville
  • Patent number: D291866
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: September 15, 1987
    Assignee: Brice Ilotan Research Corporation
    Inventor: Michael F. Brice
  • Patent number: D291867
    Type: Grant
    Filed: February 6, 1985
    Date of Patent: September 15, 1987
    Assignee: Timex Corporation
    Inventor: Barry D. Berger
  • Patent number: D291868
    Type: Grant
    Filed: November 2, 1984
    Date of Patent: September 15, 1987
    Assignee: Beecham Group p.l.c.
    Inventor: Brian R. Hindle
  • Patent number: D291869
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: September 15, 1987
    Assignee: Partecipazioni Bulgari S.p.A.
    Inventor: Gianni Bulgari
  • Patent number: D291870
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: September 15, 1987
    Assignee: Federal Signal Corporation
    Inventors: Sigmund S. Urbanski, Richard W. Condon, Edward S. Stanuch
  • Patent number: D291871
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: September 15, 1987
    Inventor: Warren L. Harvey
  • Patent number: D291872
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: September 15, 1987
    Assignee: Paccar Inc.
    Inventors: Wayne K. Simons, Roy L. Meryman, Larry W. Orr, Donald A. Richardson
  • Patent number: D291873
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: September 15, 1987
    Inventor: Yoshio Koyama
  • Patent number: D291874
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: September 15, 1987
    Assignee: Bridgestone Corporation
    Inventors: Toshio Hayakawa, Shinichiro Ohkuni
  • Patent number: D291875
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: September 15, 1987
    Assignee: Bridgestone Corporation
    Inventors: Toshio Hayakawa, Toru Osawa
  • Patent number: D291876
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: September 15, 1987
    Assignee: Bridgestone Corporation
    Inventors: Toshio Hayakawa, Yasuo Himuro, Toru Osawa
  • Patent number: D291877
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: September 15, 1987
    Assignee: Bridgestone Corporation
    Inventors: Hideaki Nishio, Kiyoshi Takase
  • Patent number: D291878
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: September 15, 1987
    Assignee: Cook Manufacturing Corporation
    Inventor: Gregory D. Cook
  • Patent number: D291879
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: September 15, 1987
    Assignee: General Motors Corporation
    Inventors: William F. Boyle, Maurice P. Chandler
  • Patent number: D291880
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: September 15, 1987
    Assignee: General Motors Corporation
    Inventor: Stuart B. Shuster
  • Patent number: D291881
    Type: Grant
    Filed: August 12, 1983
    Date of Patent: September 15, 1987
    Assignee: Investment Associates, Inc.
    Inventor: Nicholas J. Koushiafes
  • Patent number: D291882
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: September 15, 1987
    Assignee: Dictaphone Corporation
    Inventors: John W. Hoover, Richard G. Rutkowski, Rocco Luppino
  • Patent number: D291883
    Type: Grant
    Filed: October 2, 1986
    Date of Patent: September 15, 1987
    Assignee: Outdoor Horizons, Inc.
    Inventor: Robert Snyder
  • Patent number: D291884
    Type: Grant
    Filed: November 23, 1984
    Date of Patent: September 15, 1987
    Assignee: Siemens Aktiengesellschaft
    Inventors: Wolfgang Muenscher, Siegfried Schoen
  • Patent number: D291885
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: September 15, 1987
    Assignee: Siemens Aktiengesellschaft
    Inventor: Harry Hentschel
  • Patent number: D291886
    Type: Grant
    Filed: November 27, 1985
    Date of Patent: September 15, 1987
    Assignee: Motorola, Inc.
    Inventors: William J. Scheid, Robert Kurcbart
  • Patent number: D291887
    Type: Grant
    Filed: May 31, 1985
    Date of Patent: September 15, 1987
    Assignee: Oscarvision Systems, Inc.
    Inventor: Henry F. Oscar
  • Patent number: D291888
    Type: Grant
    Filed: January 3, 1985
    Date of Patent: September 15, 1987
    Assignee: Tradebest International Corporation
    Inventors: Peter Fong, Tsang H. T. Henry