Patents Issued in April 14, 2009
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Patent number: 7517821Abstract: An automobile interior board includes a base layer; and a nonwoven or woven surface layer, laminated on at least one surface of the base layer. The base layer is comprised of a composite material of: a first fiber, comprised of a bamboo fiber; a second fiber, comprised of one of cotton, hemp and mixture of cotton and hemp; and a biodegradable resin. Weight percentage of the first fiber, the second fiber and the biodegradable resin satisfies a following equation, the first fiber: the second fiber: the biodegradable resin=30 to 70:10 to 60:20 to 60. The surface layer is comprised of one of a PET resin fiber and a natural material-derived fiber.Type: GrantFiled: December 13, 2006Date of Patent: April 14, 2009Assignee: Mitsubishi Jidosha Kogyo K.K.Inventors: Isamu Terasawa, Kazunori Tsuneoka, Hiroshi Kimura
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Patent number: 7517822Abstract: The invention relates to a borosilicate glass having the following composition (in wt. % based on oxide content): between 55 and 80 of SiO2; between 8 and 25 of B2O3; between 0.5 and 10 of Al2O3; between 1 and 16 of Li2O+Na2O+K2O; between 0 and 6 of MgO+CaO+SrO+BaO; between 0 and 3 of ZnO; between 0 and 5 of ZrO2; between 0 and 5 of Bi2O3; and between 0 and 3 of MoO3; the sum of the Bi2O3 and MoO3 amounting to between 0.01 and 5. The invention also relates to a fluorescent lamp, especially a miniature fluorescent lamp.Type: GrantFiled: March 26, 2003Date of Patent: April 14, 2009Assignee: Schott AGInventors: Joerg Fechner, Franz Ott, Rainer Haspel, Ralf Diezel
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Patent number: 7517823Abstract: A dielectric porcelain composition here contains as main components BaO, Nd2O3, TiO2, MgO and SiO2 at the given ratios and as subordinate components ZnO, B2O3 and CuO at given ratios, so that it can have a low-temperature sintering capability stable and reliable enough to permit a conductor formed of Ag, an alloy containing Ag as a main component or the like to be used as an internal conductor. It is also possible to obtain a dielectric porcelain composition that has limited resonance frequency changes with temperature changes and a specific dielectric constant lower than that of a BaO-rare earth oxide-TiO2 base dielectric porcelain composition, and so is suitable for multilayer type device formation.Type: GrantFiled: September 29, 2005Date of Patent: April 14, 2009Assignee: TDK CorporationInventors: Tomohiro Arashi, Yasuharu Miyauchi
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Patent number: 7517824Abstract: The present invention relates to a process for stripping hydrocarbons from a catalyst, comprising the step of contacting the catalyst with steam at stripping conditions, wherein the catalyst comprises a molecular sieve having a structure type of MWW, the steam comprises at least 90 wt. % vapor phase H2O, the stripping conditions comprise a temperature range from about 100° C. to about 250° C., a pressure less than 310 kpa-a, and a WHSV range from about 0.01 to about 100 hr?1.Type: GrantFiled: December 6, 2005Date of Patent: April 14, 2009Assignee: ExxonMobil Chemical CompanyInventors: Stephen H. Brown, Khavinet Lourvanij
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Patent number: 7517825Abstract: A process for converting polyalkylaromatics to monoalkylaromatics, particularly cumene, in the presence of a modified LZ-210 zeolite is disclosed. The process attains greater selectivity, reduced formation of undesired byproducts, and increased activity.Type: GrantFiled: January 12, 2007Date of Patent: April 14, 2009Assignee: UOP LLCInventors: Thomas M. Reynolds, Christopher J. Garrett, Deng-Yang Jan, Robert J. Schmidt, Mathias P. Koljack
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Patent number: 7517826Abstract: A multi-layer emission control catalyst exhibits improved CO and HC reduction performance. The bottom layer includes a supported catalyst comprising platinum and palladium particles or palladium and gold particles. The middle layer includes zeolites. The top layer includes a supported catalyst comprising platinum and palladium particles. The use of zeolite mixture in the middle layer further improves CO and HC reduction performance in comparison with using zeolite of a single type. The use of a supported catalyst comprising palladium and gold particles in the bottom layer further improves CO and HC reduction performance in comparison with using a supported catalyst comprising platinum and palladium particles.Type: GrantFiled: November 20, 2007Date of Patent: April 14, 2009Assignee: Nanostellar, Inc.Inventors: Kyle L. Fujdala, Timothy J. Truex
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Patent number: 7517827Abstract: The present invention relates to a cracking catalyst composition for cracking heavy hydrocarbon and processes for preparing the catalyst. The process can include treating zeolite with sodium free basic compound with or without phosphate, treating an alumina with a dilute acid, acidifying a colloidal silica, preparing a fine slurry of clay with a source of phosphate, adding alumina slurry and/or acidified colloidal silica to clay phosphate slurry, adding treated zeolite and spray-drying the slurry and calcining the same to obtain a cracking catalyst having adequate ABD and attrition resistance property.Type: GrantFiled: August 17, 2006Date of Patent: April 14, 2009Assignee: Indian Oil Company LtdInventors: Gopal Ravichandran, Biswanath Sarkar, Mohan P. Kuvettu, Deepa Megavathu, Sanjay K Ray, Shiba P. Choudhury, Sudipta Roy, Venkatachalam Krishnan, Satish Makhija
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Patent number: 7517828Abstract: A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.Type: GrantFiled: April 20, 2004Date of Patent: April 14, 2009Assignee: Toagosei Co., Ltd.Inventor: Takahiko Akiyama
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Patent number: 7517829Abstract: The invention relates to a process for the production of Raney nickel catalysts. In this process, the melt of an alloy comprising from 40 to 95 wt. % aluminum, from 5 to 50 wt. % nickel, 0 to 20 wt. % iron, from 0 to 15 wt. % of one or more transition metals selected from the group consisting of cerium, cerium mixed metal, vanadium, niobium, tantalum, chromium, molybdenum and manganese, and, optionally, additional glass-forming elements, is brought into contact with one or more rotating cooling rollers or cooling plates and is allowed to cool and solidify thereon. The cooling rollers have a surface structured by means of transverse grooves, and the cooling plates have a surface structured by means of grooves extending outwards from the axis of rotation. The rapidly solidified alloy on the cooling rollers or the cooling plates is then subjected to treatment with one or more organic or inorganic bases.Type: GrantFiled: September 2, 2004Date of Patent: April 14, 2009Assignee: Bayer MaterialScience AGInventors: Joachim Zechlin, Gerhard Wegener, Hans Warlimont
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Patent number: 7517830Abstract: In the distribution of surface vacancies which open on the surface of the cellular walls of pores, more than 8% of total opening area of all surface vacancies that the pores are open on the surface of the cellular walls is occupied by total opening area of surface vacancies having maximum diameter of from 10 to 50 ?m, in the distribution of inner pores, more than 20% of total cross-sectional area of all pores is occupied by total cross-sectional area of pores having cross-sectional area equivalent to that of a circle having diameter more than 300 ?m.Type: GrantFiled: February 13, 2004Date of Patent: April 14, 2009Assignee: Toyota Jidosha Kabushiki KaishaInventors: Kumiko Nomura, Satoko Inuduka
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Patent number: 7517831Abstract: This pumice stone, which has a carbon content of between 5 and 15% by weight, is capable of adsorbing hydrocarbons but is hydrophobic. It can be applied in decontaminating a sheet of water.Type: GrantFiled: May 27, 2005Date of Patent: April 14, 2009Assignee: Sem StoneInventors: Jean-Pierre Camp, Serge Bensaid
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Patent number: 7517832Abstract: Disclosed is a fibrous activated carbon wherein fine pores in the surface of the activated carbon have diameters of 0.1-200 nm and the activated carbon is in the form of fiber having a fiber diameter of not more than 1000 nm.Type: GrantFiled: September 16, 2004Date of Patent: April 14, 2009Assignee: Teijin LimitedInventors: Hiroshi Sakurai, Mai Kitahara, Masumi Hirata, Toru Sawaki
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Patent number: 7517833Abstract: It is an object of the present invention to provide a sheet having a good transferring property, that is, a thermal transfer sheet which has high transfer sensitivity and good adhesion between a base material and a dye layer, and has high transfer sensitivity, and can be used for high speed printing and attain printed substance having a high density and sharpness, a protective layer transfer sheet which has a good transferring property and produces extremely low static electricity in transferring, and a printed substance which is superior in an antistatic property, plasticizer resistance and transparency.Type: GrantFiled: October 25, 2005Date of Patent: April 14, 2009Assignee: Dai Nippon Printing Co., Ltd.Inventors: Daisuke Fukui, Kenichi Hirota, Sakie Iwaoka
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High temperature superconducting (HTS) tape coil with enhanced protection and method for making same
Patent number: 7517834Abstract: The invention provides an improved method of manufacturing an HTS tape coil for an MRI device with enhanced protection, the method comprising attaching high-Q capacitors at each end of an HTS wire, removing substantially all electrically conductive sheathing material on an inner side of the HTS wire, while retaining substantially all electrically conductive sheathing material on an outer side of the HTS wire. The invention also provides an HTS wire made in accordance with the foregoing method.Type: GrantFiled: January 23, 2007Date of Patent: April 14, 2009Assignee: The University of Hong KongInventors: Yum Wing Wong, Edward S. Yang -
Patent number: 7517835Abstract: Compositions for increasing the thermal and pressure stability of well fluids viscosified using viscoelastic surfactants, the compositions including an effective amount of an oligomeric or polymeric compound that has a thermally stable backbone structure and at least one pendent viscoelastic surfactant functional group. Preferred compositions for increasing the stability of well fluids viscosified using monomeric viscoelastic surfactants include an effective amount of an oligomeric or polymeric compound that has a thermally stable backbone structure and a multiplicity of pendent viscoelastic surfactant functional groups attached to said backbone structure through relatively long hydrocarbon chains, 1 to 18 carbons in length.Type: GrantFiled: November 14, 2005Date of Patent: April 14, 2009Assignee: M-I LLCInventors: Robert L. Horton, Bethicia B. Prasek, Frederick B. Growcock, David P. Kippie, John W. Vian, Kamila B. Abdur-Rahman, Morris Arvie
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Patent number: 7517836Abstract: Embodiments of the present invention are directed to defoaming methods and compositions for well treatment fluids. An exemplary embodiment of the present invention provides a method of defoaming a well treatment fluid, comprising combining a defoaming composition with the well treatment fluid, wherein the defoaming composition comprises an amide of a carboxylic acid, a polypropylene glycol, an ethoxylated and propoxylated fatty alcohol, an ethoxylated alcohol comprising from 3 carbons to 6 carbons, and a hydrophobic silica in an amount of up to about 3% by weight of the defoaming composition.Type: GrantFiled: March 7, 2007Date of Patent: April 14, 2009Assignee: Halliburton Energy Services, Inc.Inventors: Jiten Chatterji, Bobby J. King
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Patent number: 7517837Abstract: Lubricant compositions based on a biodegradable base oil, such as a polyol ester or polyalkylene glycol, a calcium sulfonate based thickener and a naturally occurring phospholipid as an anti-wear additive, such as lecithin for environmentally sensitive applications and when having a specific gravity greater than 1.0 at 60° F. (15.6° C.) for marine applications are provided. The thickener may include a linear alkybenzene sulfonic acid, acetic acid and 12 hydroxystearic acid and a calcium carbonate solid film lubricant. The lubricant submerges when dispensed on water avoiding formations of a surface sheen and biodegrades when submerged resulting in a water ecology friendly lubricant.Type: GrantFiled: May 22, 2003Date of Patent: April 14, 2009Assignee: Anderol, Inc.Inventors: John M. Kurosky, Zulfiqar Ahmed Tahir
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Patent number: 7517838Abstract: Disclosed herein is a lubricating oil for bearings comprising (a) a diester represented by General Formula (1) wherein R1 and R2 are the same or different, and each represents a C3-C17 linear alkyl group; A represents a C2-C10 linear alkylene group or A represents a branched alkylene group consisting of a linear alkylene group, the linear alkylene group being the principal chain, and one or more alkyl groups (branches) bonded to the linear alkylene group, wherein the total number of carbon atoms of the linear alkylene group and the one or more alkyl groups is 3 to 10; with the proviso that when A is a branched alkylene group and has two or more alkyl groups, the two or more alkyl groups are not bonded to the same carbon atom; or a mixture of the diester with an additional base oil and (b) at least one member selected from the group consisting of phenol-based antioxidants and amine-based antioxidants, and optionally containing (c) at least one member selected from the group consisting of Phosphorus-basedType: GrantFiled: August 22, 2003Date of Patent: April 14, 2009Assignee: New Japan Chemical Co., Ltd.Inventors: Yasuyuki Kawahara, Kouji Takahashi, Hirotaka Tomizawa
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Patent number: 7517839Abstract: A lubricating oil for compression-type refrigerator includes, as a main component, a polyoxyalkyleneglycol derivative represented by the general formula: R1(OR2)m-OR3]n wherein R1 is a methyl group, R2 is a propylene group, R3 is a methyl group, n is an integer of 1 and m is an integer of 12 to 80, and 1,1,1,2-tetrafluoroethane. The derivative has a kinematic viscosity of 5 to 50 cSt at 100° C.Type: GrantFiled: September 12, 2002Date of Patent: April 14, 2009Assignee: Idemitsu Kosan Co., Ltd.Inventors: Yasuhiro Kawaguchi, Nobuaki Shimizu, Masato Kaneko, Hiroshi Nagakawa
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Patent number: 7517840Abstract: Perfume compositions and method of formulating perfume compositions designed for use in rinse-off or high dilution systems provide a sustained linear release and/or a delayed release, with the odorants selected according to their mass transfer values, odor detection thresholds and/or calculated odor indices.Type: GrantFiled: April 7, 2006Date of Patent: April 14, 2009Assignee: Givaudan Fragrances CorporationInventors: Addi Fadel, Richard Turk, Grant Mudge, Jill Mattila, Veronica Goberdhan
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Patent number: 7517841Abstract: Embodiments of the invention relate to providing a cleansing article. The cleansing article generally includes one or more of a receptacle, a container, one or more segments, a material piece, and one or more of a solid cleanser and a liquid cleanser. The receptacle, the container, the one or more segments, and the material piece are each generally formed of an open cell material. In certain embodiments, the receptacle is used with the one or more segments to increase the activating area of the receptacle. As such, more soapy lather can be created via the one or more solid cleanser and liquid cleanser in comparison to solely using the receptacle. In certain embodiments, the one or more segments are held within the receptacle via the container or via the material piece. As such, the segments being held in such fashion collectively serve as a temporary reservoir for soapy lather created.Type: GrantFiled: October 16, 2005Date of Patent: April 14, 2009Inventors: Estella L. Coleman, Michael V. Coleman
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Patent number: 7517842Abstract: An antimicrobial hand wash comprises an active ingredient and an amidoamine based cationic surfactant having a fatty chain with from 6 to 24 carbon atoms. These cationic surfactants are compatible with common active ingredients such that antimicrobial efficacy is maintained, while foam quality is improved when the hand wash is dispensed as foam. Other antimicrobial hand washes include specific amidoamine based cationic surfactants that dissolve at least a portion of the active ingredient, thus reducing the amount of solids in the formulation, and, in some instances, making a cold manufacturing process possible.Type: GrantFiled: November 10, 2006Date of Patent: April 14, 2009Assignee: GOJO Industries, Inc.Inventors: Ronald A. Barnhart, David P. Lerner
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Patent number: 7517843Abstract: The present invention provides a method for producing a product with a constant weight made from a compressible fluid which comprises feeding the compressible fluid into a prescribed vessel, characterized in that the volume of the compressible fluid to be fed into the vessel is adjusted according to variations of specific gravity of the compressible fluid to be fed into the vessel so that the weight of the compressible fluid to be fed is constant.Type: GrantFiled: September 20, 2001Date of Patent: April 14, 2009Assignee: Kao CorporationInventors: Yasunori Miyamoto, Tadao Abe
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Patent number: 7517844Abstract: A composition comprising a mixing product of: (i) a first acid having a pKa of less than 3, in an amount by weight of 1-10%, (ii) a second acid having a pKa of greater than 3, in an amount by weight of 1-10%, (iii) a nonionic surfactant in an amount by weight of 1-7%; and (iv) water; wherein the composition has a pH of less than 2.5. The composition can be used for the removal of grease, lime scale, soap scum, and rust on hard surfaces.Type: GrantFiled: June 4, 2008Date of Patent: April 14, 2009Assignee: Colgate-Palmolive CompanyInventors: Patrick Diet, Jean Massaux, Isabelle Leonard
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Patent number: 7517845Abstract: Compositions comprising 1,1,1,3,3-pentafluorobutane and more than 5% by weight of at least one non-flammable fluoro compound, and use thereof.Type: GrantFiled: February 20, 2007Date of Patent: April 14, 2009Assignee: Solvay S.A.Inventors: Pierre Dournel, Pierre Barthelemy
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Patent number: 7517846Abstract: The invention is a solid chemical concentrate system of at least two cooperative shapes. The first shape is an inwardly curved bar having an inner opening. The second shape is an insert which is capable of interlocking with the bar by insertion into the bar inner opening. The solid chemical concentrate provides chemical systems having active constituents which may be the same, different but compatible or functionally and chemically incompatible combined within one matrix to provide at least one substantially continuous surface. The system may also comprise an aqueous soluble or dispersible polymeric film cover.Type: GrantFiled: October 20, 2005Date of Patent: April 14, 2009Assignee: Ecolab Inc.Inventors: Elizabeth J. Gladfelter, Tina O. Outlaw, James L. Copeland, Rhonda K. Schulz, Daniel K. Boche, Jeff W. Peterson
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Patent number: 7517847Abstract: Bleaching product in the form of a coated substrate comprising a water-soluble film and a coating comprising a bleaching agent.Type: GrantFiled: May 11, 2006Date of Patent: April 14, 2009Assignee: The Procter & Gamble CompanyInventors: Vincenzo Catalfamo, Frank William Denome, Dennis Allen Beckholt, Yousef Georges Aouad, James Michael Archbold
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Patent number: 7517848Abstract: A multiuse cleaning device in a solid state containing a homogeneous quantity of cleaning agent configured to dissolve and release a substantially consistent quantity of cleaning agent over a plurality of wash and rinse cycles. The cleaning agent includes a gas-releasing component and potassium silicate as a solubility control component to limit the solubility of the cleaning agent. The cleaning agent may include other ingredients such as an alkalinity agent as a pH regulator, a water softener to solvate metal ions in a solution of water, an optical brightener, an anti-redeposition agent, fragrances, surfactants, and other ingredients. Controlled dissolution of the cleaning agent composition releases a desired quantity of cleaning agent in each cleaning cycle over a plurality of cycles. A porous enclosure may be disposed around the solid cleaning agent.Type: GrantFiled: September 27, 2006Date of Patent: April 14, 2009Assignee: Eco-Safe Technologies, LLCInventors: K Donald Evans, Cory E. Cook
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Patent number: 7517849Abstract: ATP-binding cassette (ABC) transporters generally contain a number of transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides inhibit ABC transporter function, presumably by disrupting the structure of the ABC transporter. Negatively charged residues are added at the extracellular terminus to promote correct orientation of the peptide in the membrane, and residues considered to aid solubility may be added at that terminus to increase solubility. Exemplary ABC transporters that can be inhibited by these peptides include MDR1, MRP1, MRP2 and BCRP. The invention further provides nucleic acids encoding the peptides, expression cassettes comprising the nucleic acids, and host cells expressing the expression cassettes. The invention further provides a simple and inexpensive assay for determining whether a potential chemotherapeutic agent can inhibit the activity of P-gly-coprotein.Type: GrantFiled: November 17, 2000Date of Patent: April 14, 2009Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventors: Nadya I. Tarasova, Christopher J. Michejda, Michael M. Gottesman, Christine A. Hrycyna
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Patent number: 7517850Abstract: Artificial particles known as calcium phosphate nanoclusters are disclosed. The particles contain high concentrations of calcium, particularly for use in nutritional products, neutraceuticals, and pharmacological preparations.Type: GrantFiled: June 12, 2006Date of Patent: April 14, 2009Inventor: Carl Holt
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Patent number: 7517851Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.Type: GrantFiled: March 16, 2006Date of Patent: April 14, 2009Assignee: The University of WashingtonInventors: Cho-chou Kuo, Albertina F. Swanson, Sen-Itiroh Hakomori, Noriko Takahashi
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Patent number: 7517852Abstract: The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of treating (e.g., killing or inhibiting growth of) bacteria. For example, the present invention provides pharmaceutical compounds (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of using the same in research, therapeutic and drug screening applications.Type: GrantFiled: July 28, 2006Date of Patent: April 14, 2009Assignee: Biosynexus IncorporatedInventors: Scott Michael Walsh, Mary Catherine Pittaway, James J. Mond
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Patent number: 7517853Abstract: The invention features somatostatin-dopamine chimeric analogs and methods relating to their therapeutic use for the treatment of neoplasia, acromegaly, and other conditions.Type: GrantFiled: April 8, 2004Date of Patent: April 14, 2009Assignee: Ipsen Pharma S.A.S.Inventors: Zheng Xin Dong, Michael DeWitt Culler, Yeelena Shen
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Patent number: 7517854Abstract: Small cyclic peptides of the formula X1-X2-X3-X4-X5-X6-X7-R1 comprising 7-12 amino acid residues are provided. Said peptides are MC4 receptor agonists, and thus useful in the treatment of obesity and related diseases.Type: GrantFiled: March 30, 2006Date of Patent: April 14, 2009Assignee: Novo Nordisk A/SInventors: Kilian Waldemar Conde-Frieboes, Ulrich Sensfuss, Kjeld Madsen, Nils Langeland Johansen, Leif Christensen, Thomas Kruse Hansen, Birgitte Schjellerup Wulff
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Patent number: 7517855Abstract: The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, pharmaceutical compositions of these peptides and methods of using these peptides and pharmaceutical compositions of these peptides to treat diseases associated with aberrant vascularization.Type: GrantFiled: November 25, 2003Date of Patent: April 14, 2009Assignee: Attenuon, LLCInventors: Robert J. Ternansky, Stephanie A. Hopkins, Won Hyung Yoon, Amy L. Allan, Patricia L. Gladstone, Sean M. O'Hare, Fernando Donate, Andrew Mazar, Graham Parry, Marian Plunkett
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Patent number: 7517856Abstract: The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate group of said sulfated polysaccharide. The bioactive polypeptide can be a heparin-binding polypeptide and/or a positively-charged polypeptide. Also, provided are delivery systems and methods for sustained release of said bioactive polypeptide(s) using said bioconjugates.Type: GrantFiled: October 11, 2005Date of Patent: April 14, 2009Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Smadar Cohen, Inbar Freeman
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Patent number: 7517857Abstract: Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.Type: GrantFiled: December 23, 2005Date of Patent: April 14, 2009Assignees: POSCO, Postech FoundationInventors: Sung-Ho Ryu, Pann-Ghill Suh, Yoe-Sik Bae, Ji-Young Song
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Patent number: 7517858Abstract: Lipid prodrugs of pharmaceutical agents and their analogs that have increased anticancer, anti-viral, anti-inflammatory, anti-proliferative activity over the parent drug, and methods for making lipid prodrugs. Compositions comprising lipid prodrugs for treating disease and methods for treating disease which involve using the compositions.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 2009Assignee: The Regents of the University of CaliforniaInventors: Karl Y. Hostetler, Ganesh D. Kini, James R. Beadle
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Patent number: 7517859Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: May 3, 2006Date of Patent: April 14, 2009Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yonghua Gai, Datong Tang, Ying Sun, Zhigang Chen, Yat Sun Or, Zhe Wang
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Patent number: 7517860Abstract: It has been discovered that the low density lipoprotein receptor (LDLR) degrades the lipoprotein apoB. Based on this observation, an artificial fusion protein has been designed containing an LDL receptor domain attached to a localization domain which causes retention of the fusion protein inside of a cell. The fusion protein is preferably retained in the endoplasmic reticulum of the cell, where the LDLR can degrade apoB. Data shows that the technique is effective in a mammal to reduce serum LDL cholesterol levels.Type: GrantFiled: July 21, 2000Date of Patent: April 14, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Alan D Attie, Donald L Gillian-Daniel, Paul W. Bates
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Patent number: 7517861Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.Type: GrantFiled: July 9, 2004Date of Patent: April 14, 2009Assignee: University of Iowa Research FoundationInventors: Arthur M. Krieg, Joel N. Kline
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Patent number: 7517862Abstract: The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3? ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5? end.Type: GrantFiled: August 25, 2004Date of Patent: April 14, 2009Assignee: Idera Pharmaceuticals, Inc.Inventors: Sudhir Agrawal, Ekambar R. Kandimalla, Dong Yu, Lakshmi Bhagat
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Patent number: 7517863Abstract: One aspect of the current invention is a method designing and using species-specific or synthetic signal peptides and GHRH sequences for the purpose of preventing and/or treating chronic illness in a subject by utilizing methodology that administers a single dose of nucleic acid expression vector or nucleic acid expression construct encoding a GHRH or functional biological equivalent to a subject through a parenteral route of administration.Type: GrantFiled: January 13, 2005Date of Patent: April 14, 2009Assignee: VGX Pharmaceuticals, Inc.Inventors: Ruxandra Draghia-Akli, Melissa Pope
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Patent number: 7517864Abstract: This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of VEGF and/or VEGFR gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of VEGF and/or VEGFR genes.Type: GrantFiled: December 9, 2005Date of Patent: April 14, 2009Assignee: Sirna Therapeutics, Inc.Inventors: Chandra Vargeese, Vasant Jadhav, David Morrissey
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Patent number: 7517865Abstract: The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.Type: GrantFiled: April 26, 2006Date of Patent: April 14, 2009Assignee: Alnylam Pharmaceuticals, Inc.Inventor: Rachel Meyers
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Patent number: 7517866Abstract: The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding splice variants of LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine.Type: GrantFiled: May 12, 2006Date of Patent: April 14, 2009Inventor: Scott D. Boden
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Patent number: 7517867Abstract: The invention provides compounds of formula I or formula II: wherein: the bond represented by — is a single bond or a double bond, and R1-R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.Type: GrantFiled: March 6, 2007Date of Patent: April 14, 2009Assignee: Rutgers, The State University of New JerseyInventors: Edmond J. LaVoie, Alexander L. Ruchelman, Leroy F. Liu
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Patent number: 7517868Abstract: The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+, K+, Mg2+, or Ca2+ salt of said chemical compound. The chemical compound is a chelator which chelates sodium, potassium or lithium, magnesium, calcium, copper, iron, lead, zinc, aluminum, mercury, cadmium, or chromium. It is also be used as an artery plaque dissolver and/or to treat age-related degenerative disorders, such as Alzheimer's disease. The present invention also provides a method for producing the phytic citrate compound and/or its salt.Type: GrantFiled: December 30, 2005Date of Patent: April 14, 2009Assignee: IP-6 Research IncInventors: Carl A. Coppolino, AbulKalam M. Shamsuddin
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Patent number: 7517869Abstract: Process for the specific fluorination of the phosphorus atom of a phosphonocinnamic compound of the general formula (II) or (II?): X being selected from: an oxygen atom, a sulfur atom, R1, R2, R3, R4, R5 and R6 being selected from: H, an alkyl group, an aryl group, OH, O-alkyl, S-alkyl, NH2, NH-alkyl, N-(alkyl)2; R7 being selected from: H, an alkyl group, an aryl group, a silyl group; R8 being selected from: H, an alkyl group, an aryl group, TBDPS representing a tert-butyldiphenylsilyl group; in the process the compound is reacted with a fluorinating agent comprising a complex formed between a tertiary amine and hydrogen fluoride.Type: GrantFiled: September 26, 2005Date of Patent: April 14, 2009Assignee: Centre National de la Recherche Scientique (C.N.R.S.)Inventors: Michel Baltas, Florence Bedos-Belval, Hubert Duran, Caroline Lapeyre, Anne-Elisabeth Negre-Salvayre
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Patent number: 7517870Abstract: The present invention concerns the use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization. Particularly, the above-mentioned diseases are (wet) age-related macular degeneration, (proliferative) diabetic retinopathy, neovascular glaucoma, retinal vein occlusion, or retinopathy of prematurity (ROP).Type: GrantFiled: December 3, 2004Date of Patent: April 14, 2009Assignee: Fondazione TelethonInventors: Alberto Auricchio, Markus Hildinger, Enrico Maria Surace