Patents Issued in April 14, 2011
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Publication number: 20110085940Abstract: A honeycomb filter includes a honeycomb structure and a zeolite. The honeycomb structure has cell walls to define cells between the cell walls. The zeolite is supported on the cell walls. An amount of the zeolite is from about 80 g/L to about 150 g/L. The cells include a large volume cell and a small volume cell. A porosity of the cell walls is from about 55% to about 65%. A proportion of a sum of a pore volume A and a pore volume B relative to a total pore volume C is about 20% or less. The pore volume A indicates a pore volume of pores having a pore diameter of one half or less of the average pore diameter. The pore volume B indicates a pore volume of pores having a pore diameter of twice or more the average pore diameter.Type: ApplicationFiled: April 9, 2010Publication date: April 14, 2011Applicant: IBIDEN CO., LTD.Inventors: Kazutake Ogyu, Toyoki Ogasawara
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Publication number: 20110085941Abstract: A honeycomb filter includes a honeycomb structure and a zeolite. The honeycomb structure has cell walls to define cells between the cell walls. The zeolite is supported on the cell walls. An amount of the zeolite is from about 80 g/L to about 150 g/L. A porosity of the cell walls is from about 55% to about 65%. A cell density in a cross section perpendicular to the longitudinal direction is from about 46.5 pcs/cm2 to about 62.0 pcs/cm2. A thickness of the cell walls is from about 0.2 mm to about 0.3 mm. The cells include a large volume cell and a small volume cell. An area ratio of a cross sectional area of the large volume cell relative to a cross sectional area of the small volume cell is from about 1.4 to about 2.4.Type: ApplicationFiled: April 19, 2010Publication date: April 14, 2011Applicant: IBIDEN CO., LTD.Inventors: Kazutake OGYU, Toyoki OGASAWARA
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Publication number: 20110085942Abstract: A honeycomb filter includes a honeycomb structure and a zeolite. The honeycomb structure includes cell walls having a porosity of about 55% to about 65% and extending along a longitudinal direction of the honeycomb structure to define cells between the cell walls. Each of the cells is sealed at either end of the cells. The zeolite is supported on the cell walls of the honeycomb structure. An amount of the zeolite supported on the cell walls is from about 80 g/L to about 150 g/L. A thermal conductivity of the cell walls supporting the zeolite is about 3 W/mK or more.Type: ApplicationFiled: May 17, 2010Publication date: April 14, 2011Applicant: IBIDEN CO., LTD.Inventors: Kazutake OGYU, Toyoki Ogasawara
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Publication number: 20110085943Abstract: The new ultraviolet and/or ozone-generation disinfection cutlery tray allows to improve the hygiene of the different cutlery items placed in it, by use of at least one ultraviolet light and/or ozone-generating source that irradiates the cutlery through the material itself making up the cutlery tray, made of a light-conductive plastic material, obtaining an homogeneous radiation, allowing objects that had been previously washed in a conventional way to maintain and conserve asepsis until the moment of use. Versions are contemplated for holding cutlery in vertical position, simultaneously allowing their drainage after washing and hygienization (FIGS. 4 and 5); and others in which the emission of ultraviolet light is located on the surface of the material making up the cutlery tray (FIG. 3). For the domestic sector, catering industry, as well as the clinical sector.Type: ApplicationFiled: June 1, 2009Publication date: April 14, 2011Inventor: Francisco Salvador Barea
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Publication number: 20110085944Abstract: Catalytic structures include a catalytic material disposed within a zeolite material. The catalytic material may be capable of catalyzing a formation of methanol from carbon monoxide and/or carbon dioxide, and the zeolite material may be capable of catalyzing a formation of hydrocarbon molecules from methanol. The catalytic material may include copper and zinc oxide. The zeolite material may include a first plurality of pores substantially defined by a crystal structure of the zeolite material and a second plurality of pores dispersed throughout the zeolite material. Systems for synthesizing hydrocarbon molecules also include catalytic structures. Methods for synthesizing hydrocarbon molecules include contacting hydrogen and at least one of carbon monoxide and carbon dioxide with such catalytic structures.Type: ApplicationFiled: December 16, 2010Publication date: April 14, 2011Applicant: BATTELLE ENERGY ALLIANCE, LLCInventors: Harry W. Rolllins, Lucia M. Petkovic, Daniel M. Ginosar
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Publication number: 20110085945Abstract: A mixing unit, a mixing device, an agitation impeller and a pump mixer can mix a large amount of fluid while having significant mixing effects in a small space. There are also provided a mixing system that uses the pump mixer and achieves a continuous operation and a reaction device that uses the mixing unit and achieves an efficient operation. The mixing unit (1) includes: a stacked member (2) in which a plurality of mixing elements (21) are stacked; and a first plate (3) and a second plate (4) between which the stacked member (2) is sandwiched and which are arranged opposite each other.Type: ApplicationFiled: June 16, 2009Publication date: April 14, 2011Applicant: ISEL CO., LTD.Inventor: Noboru Mochizuki
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Publication number: 20110085946Abstract: The invention relates to a novel installation for providing a product in pasteurized form, said product comprising at least one liquid component and fibrous and/or solid components.Type: ApplicationFiled: May 19, 2009Publication date: April 14, 2011Applicant: KHS GmbHInventor: Ludwig Clüsserath
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Publication number: 20110085947Abstract: The purpose of the present invention is to propose a reliable, economically viable autoclave that also allows rapid heat treatment of food or pharmaceutical products in industrial quantities. To this end, the subject of the invention is a system for shaking items, inside a device under pressure, comprising a chamber (100) equipped with a heating means (110) and with a pressurizing means (115), and a storage basket (200) for the items (P) coupled to a translational shaking means (300, 310-320-330-340), wherein the basket (200) is slidably mounted on a chassis (400) exhibiting a platform (410) supported by support columns (420) passing through the chamber (100) in a fluidtight and decoupled manner and intended to be secured to an immovable support (600).Type: ApplicationFiled: October 13, 2009Publication date: April 14, 2011Inventors: Jean-Patrick Roumagnac, Francisco Naveros, Philippe Cocco
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Publication number: 20110085948Abstract: Embodiments of the present invention include a specimen collection assembly that limits or eliminates the need for transferring a specimen sample from one container to another. The specimen collection assembly includes a fecal loop, a filter and a lid each to be employed with a vile. The filter is attachable to a distal portion of the fecal loop. The lid is configured to be positioned over the open end of the vile with both the fecal loop and filter positioned in the vile. With this arrangement, a liquid solution can be introduced into the vile and then agitated to mix with a specimen sample. The fecal loop with the attached filter can then be withdrawn from the vile to leave the remaining filtered and mixed liquid solution in the vile.Type: ApplicationFiled: October 12, 2009Publication date: April 14, 2011Inventors: Val L. Poll, Steven J. Miller, Jay J. Davis, Brian T. Leishman, Joshua L. Kirk
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Publication number: 20110085949Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.Type: ApplicationFiled: October 8, 2009Publication date: April 14, 2011Inventors: Emmanuel Roy, Teodor Veres
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Publication number: 20110085950Abstract: A microfluidic system based on centrifugal force and a bio cartridge for the microfluidic system are provided. The system includes a spindle motor, a rotatable frame detachably mounted on the motor and having a plurality of cells separated by partition walls, and the bio cartridge detachably accommodated in one of the plurality of cells. The bio cartridge includes a chamber for storing a fluid, a channel for transporting the fluid, and a valve for controlling the flow of the fluid. The valve may include a phase transition material, and exothermic minute particles dispersed in the material and generating heat when energy is applied thereto.Type: ApplicationFiled: October 8, 2009Publication date: April 14, 2011Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Beom Seok LEE, Jeong Gun LEE, Yoon Kyoung CHO, Ki Eun KIM, Jung Nam LEE
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Publication number: 20110085951Abstract: A sample storage, in which barcodes and two-dimensional codes written on the outer surface of the sample storage can be read correctly without false recognition. A storage tube 110 is made of transparent material, comprising a top opening. An externally equipped opaque writable element 120 is assembled outside by covering storage tube 110 throughout from the bottom surface to the side surface. An externally equipped opaque writable element 120 is to be used as a medium to which coded information that can be read by means of optical reading is written. The top opening of the storage container 110 is sealed by the lid element screwed into or fitted into the externally equipped opaque writable element 120 not to the storage container 110. At least one window 125 is provided, which enables a sample 200 contained to be observed, with the externally equipped opaque writable element 120 assembled outside.Type: ApplicationFiled: March 11, 2009Publication date: April 14, 2011Inventors: Yoko Nakahana, Shinichiro Kakuda
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Publication number: 20110085952Abstract: A wet scrubber for absorbing a heavy metal from a gas stream, a liquor for said wet scrubber, and a power-plant comprising said wet scrubber are described. The wet scrubber has a liquor containing an oxidizer in ionic liquid. Optionally, the oxidizer has, in pure state, high vapor pressure, and in the ionic liquid, the oxidizer forms a complex that has a much lower vapor pressure. In a preferred embodiment, the liquor is substantially free of any ligand that binds to the metal to be absorbed by the liquor.Type: ApplicationFiled: December 2, 2008Publication date: April 14, 2011Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Yoel Sasson, Mandan Chidambaram, Zach Barnea
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Publication number: 20110085953Abstract: An exhaust gas purifying apparatus includes a metal casing and a honeycomb filter installed in the metal casing. The honeycomb filter includes cells, a first end face, and a second end face. The cells include a first cell and a second cell provided alternately. The first cell includes an open end on the first end face side and a sealed end on the second end face side. The second cell includes an open end on the second end face side and a sealed end on the first end face side. A cross-sectional area of the first cell is smaller than a cross-sectional area of the second cell. The first end face is disposed on a gas inlet side of the metal casing. The second end face is disposed on a gas outlet side of the metal casing.Type: ApplicationFiled: April 13, 2010Publication date: April 14, 2011Applicant: IBIDEN CO., LTD.Inventors: Kazutake Ogyu, Kenichi Makino
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Publication number: 20110085954Abstract: An arrangement and method for reducing the nitrogen oxide content in the exhaust gas of an internal combustion engine with the aid of ammonia and/or ammonia-releasing reduction agents, whereby ammonia and/or ammonia-containing reduction agent is added to the exhaust gas stream upstream of a catalyst combination composed of an SCR catalyst and a subsequent NH3-oxidation catalyst in such a way that a homogeneous mixture of exhaust gas and ammonia is present upstream of the SCR catalyst. To optimize the reaction or conversion of nitrogen oxides, disposed downstream of the combination of a first SCR catalyst and a first NH3-oxidation catalyst is at least one second catalyst having SCR activity in order in this way to reduce the nitrogen oxides formed at the first NH3-oxidation catalyst due to insufficient selectivity of the catalyst to nitrogen with not yet oxidized NH3.Type: ApplicationFiled: December 15, 2010Publication date: April 14, 2011Inventors: Andreas Doring, Florian Walde
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Publication number: 20110085955Abstract: A CO2 capture system 200 including a system for removing NO2 from a first gas stream 210 before CO2 capture is disclosed. The CO2 capture system 200 includes a protection bed 220 and a CO2 absorber 260. The protection bed 220 may absorb the NO2 or convert the NO2 to either NO or N2.Type: ApplicationFiled: October 12, 2009Publication date: April 14, 2011Applicant: ALSTOM TECHNOLOGY LTDInventor: Mikael LARSSON
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Publication number: 20110085956Abstract: A mixer and mixer assembly for turbulent mixing and enhancing a chemical reaction is provided. A method for using a mixer and mixer assembly for treatment of fluids is also provided. The mixer generally includes a first and second end, a surface configured for turbulent mixing, a catalyst supported thereon, and surface structure configured to increase interaction of catalyst and reactant. The mixer assembly generally includes a mixer inserted inside a fluid container or a tube and may also include a catalytic sleeve for enhancing interaction between catalyst and reactant.Type: ApplicationFiled: December 21, 2010Publication date: April 14, 2011Inventor: Gary R. JERNBERG
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Publication number: 20110085957Abstract: The process produces a scintillation material of formula LnX3 or LnX3:D, wherein Ln is at least one rare earth element, X is F, Cl, Br, or I; and D is at least one cationic dopant selected from the group consisting of Y, Zr, Pd, Hf and Bi. The at least one cationic dopant is present in the scintillation material in an amount of 10 ppm to 10,000 ppm. The process includes optionally mixing the compound of the general empirical formula LnX3 with the at least one cationic dopant, heating the compound or the mixture obtained by the optional mixing to a melting temperature thereof, then growing the crystal or crystalline structure and cooling the resulting crystal or crystalline structure from a growing temperature to a temperature of 100° C. at a cooling rate of less than 20 K/h.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Inventors: Johann-Christoph Von Saldern, Christoph Seitz, Lutz Parthier, Jochen Alkemper
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Publication number: 20110085958Abstract: The present invention relates to a method for preparing a lithium vanadium phosphate material comprising forming a aqueous slurry (in which some of the components are at least partially dissolved) comprising a polymeric material, an acidic phosphate anion source, a lithium compound, V2O5 and a source of carbon; wet blending said slurry, spray drying said slurry to form a precursor composition; and heating said precursor composition to produce a lithium vanadium phosphate.Type: ApplicationFiled: December 16, 2010Publication date: April 14, 2011Inventors: Jeffrey Swoyer, M. Yazid Saidi, Titus Faulker
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Publication number: 20110085959Abstract: A method for the manufacture of concentrated phosphorous acid starting from pure P4O6 is disclosed. The P4O6 is hydrolysed, preferably under stirring in water in the presence of a homogeneous Broensted acid catalyst while maintaining in the hydrolysis/reaction medium a pH below 5 whereby the free water level, at the completion of the hydrolysis, is in the range from 0 to 40%.Type: ApplicationFiled: April 24, 2009Publication date: April 14, 2011Applicant: STRAITMARK HOLDING AGInventors: Patrick Notté, Albert Devaux
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Publication number: 20110085960Abstract: A method for synthesis of high surface-area (>100 m2/g) and nanosized (?100 nm) silicon powder by initiation of self-sustained combustion reaction in a mixture of silicon dioxide and magnesium powders in a sealed reactor chamber under pressurized inert gas atmosphere. A specific feature of the method is rapid cooling of the product at a rate of 100 K/s to 400 K/s in the area directly behind the combustion front.Type: ApplicationFiled: October 13, 2009Publication date: April 14, 2011Inventors: Alexander Mukasyan, Vasiliy Mukasyan, Mikael Nersesyan
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Publication number: 20110085961Abstract: The method for producing carbon nanotubes of the invention employs a carbon source that contains carbon and is decomposed when heated and a catalyst that serves as a catalyst for production of carbon nanotubes from the carbon source, to synthesize the carbon nanotubes on a heated support placed in a reactor, the method comprising a catalyst loading step in which the catalyst starting material, as the starting material for the catalyst, is distributed over the support to load the catalyst onto the support, a synthesis step in which the carbon source is distributed over the support to synthesize the carbon nanotubes on the support, and a separating step in which a separating gas stream is distributed over the support to separate the carbon nanotubes from the support, wherein the catalyst loading step, the synthesis step and the separating step are carried out while keeping the support in a heated state and switching supply of the catalyst starting material, the carbon source and the separating gas stream.Type: ApplicationFiled: March 6, 2009Publication date: April 14, 2011Inventors: Suguru Noda, Hisashi Sugime, Yukio Yamaguchi, Toshio Osawa, Kazunori Kakehi, Kei Hasegawa, Dong Young Kim
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Publication number: 20110085962Abstract: A system for making low volatile carbonaceous material including a digestion vessel in communication with a carbonaceous material feedstock unit for producing a digested carbonaceous material; an extraction vessel in communication with the digestion vessel, the extraction vessel containing supercritical carbon dioxide fluid for extracting hydrocarbons from the digested carbonaceous material to produce an extract solvent and the low volatile carbonaceous material; and at least one separation vessel in communication with the extraction vessel for separating the extract solvent to a carbon dioxide gas and a stream of extracted hydrocarbons.Type: ApplicationFiled: December 14, 2010Publication date: April 14, 2011Inventors: Randall J. Harris, Damian Wales
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Publication number: 20110085963Abstract: A unique method of convective dissolution of salts from in situ ponds by trenching salt beds, introducing dissolution waters to promote convective dissolution, pumping out the saturated solution from the pond bottom, and introducing additional dissolution waters.Type: ApplicationFiled: September 24, 2010Publication date: April 14, 2011Inventor: Abraham Sadan
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Publication number: 20110085964Abstract: Vanadium dioxide nanoparticles prepared by an inverse micelle hydrolysis of vanadium alkoxide in the presence of a basic catalyst.Type: ApplicationFiled: January 18, 2007Publication date: April 14, 2011Inventors: Charles Lukehart, Lisa Marie Sullivan, Lang Li, William H. Morris, III
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Publication number: 20110085965Abstract: A lithium titanium oxide for an anode active material of a lithium rechargeable battery, wherein a X-ray diffraction (XRD) spectrum has a first peak of Li4Ti5O12 and a second peak, and A50-55/A78-80 is in a predetermined range, as a result of XRD analysis, where A78-80 is an Area of the first peak and A50-55 is an Area of the second peak in XRD.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: SAMSUNG SDI CO., LTD.Inventors: Jong-Hee LEE, Young-Su KIM, Jae-Myung KIM, Kyu-Nam JOO, So-Ra LEE, Deok-Hyun KIM, Gu-Hyun CHUNG, Beom-Kwon KIM, Yong-Mi YU
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Publication number: 20110085966Abstract: A method of high hydrogen recovery from syngas from a gasifier is provided. This method includes providing a syngas stream from the gasifier to first hydrogen separation device, wherein the first hydrogen separation device is a pressure swing adsorption device, thereby producing a first high purity hydrogen stream and a tailgas stream. This method also includes increasing the pressure of the tailgas stream in a first compressor; thereby producing a pressurized tailgas stream. This method also includes providing the pressurized tailgas stream to a second hydrogen separation device, thereby producing a second high purity hydrogen stream and a residue stream. This method also includes directing the residue stream to an auxiliary boiler, and combining the first high purity hydrogen product stream and the second high purity hydrogen product stream, thereby producing a high purity hydrogen product stream.Type: ApplicationFiled: October 14, 2009Publication date: April 14, 2011Applicant: Air Liquide Process & Construction, Inc.Inventors: Dennis A. Vauk, Bhadra S. Grover
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Publication number: 20110085967Abstract: A method and apparatus for producing a hydrogen containing product in which hydrocarbon containing feed gas streams are reacted in a steam methane reformer of an existing hydrogen plant and a catalytic reactor that reacts hydrocarbons, oxygen and steam. The catalytic reactor is a retrofit to the existing hydrogen plant to increase hydrogen production. The resulting synthesis gas streams are combined, cooled, subjected to water-gas shift and then introduced into a production apparatus that can be a pressure swing adsorption unit. The amount of synthesis gas contained in a shifted stream made available to the production apparatus is increased by virtue of the combination of the synthesis gas streams to increase production of the hydrogen containing product. The catalytic reactor is operated such that the synthesis gas stream produced by such reactor is similar to that produced by the steam methane reformer and at a temperature that will reduce oxygen consumption within the catalytic reactor.Type: ApplicationFiled: October 14, 2009Publication date: April 14, 2011Inventors: Troy Michael Raybold, Gregory Joseph Panuccio, Jerome Thomas Jankowiak, Vasilis Papavassiliou, Raymond Francis Drnevich
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Publication number: 20110085968Abstract: The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sungho JIN, Seunghan OH, Karla BRAMMER
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Publication number: 20110085969Abstract: Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Inventors: F. David Rollo, Jerry L. Bryant
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Publication number: 20110085970Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided, immunoconjugates, including antibody-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.Type: ApplicationFiled: November 26, 2008Publication date: April 14, 2011Inventors: Jonathan A. Terrett, Josephine M. Cardarelli, Chetana Rao-Naik, Bingliang Chen, David J. King
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Publication number: 20110085971Abstract: The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.Type: ApplicationFiled: October 15, 2010Publication date: April 14, 2011Inventors: Dan A. Buzatu, Jon G. Wilkes, Dwight Miller, Jerry A. Darsey, Tom Heinze, Alex Birls, Richard Beger
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Publication number: 20110085972Abstract: The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.Type: ApplicationFiled: October 15, 2010Publication date: April 14, 2011Inventors: Dan A. Buzatu, Jon G. Wilkes, Dwight Miller, Jerry A. Darsey, Tom Heinze, Alex Birts, Richard Beger
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Publication number: 20110085973Abstract: The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.Type: ApplicationFiled: March 18, 2009Publication date: April 14, 2011Inventors: Kuo-Jang Kao, Andrew T. Huang
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Publication number: 20110085974Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.Type: ApplicationFiled: June 12, 2009Publication date: April 14, 2011Applicants: Cedars-Sinai Medical Center, Emory UniversityInventors: Leland W.K. Chung, Xiaojian Yang, Jianjun Cheng, Rong Tong
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Publication number: 20110085975Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.Type: ApplicationFiled: November 29, 2010Publication date: April 14, 2011Applicant: NATURAL PHARMACIA INTERNATIONAL, INC.Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
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Publication number: 20110085976Abstract: The present invention relates to a method for detecting heart damage in a patient. The invention also relates to methods for treatment of patients identified as having heart damage. The invention further pertains to methods for evaluating the efficacy of an ongoing therapeutic regimen designed to treat a damaged heart in a patient.Type: ApplicationFiled: May 12, 2008Publication date: April 14, 2011Applicant: ACORDA THERAPEUTICS, INC.Inventors: Xinhua Yan, Anthony O. Caggiano
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Publication number: 20110085977Abstract: The present invention relates to methods for determining whether blood flow is restricted in a blood vessel of an individual suspected of compromised blood flow in the vessel, the method comprising the steps of delivering UTP, a derivative thereof, or a salt thereof to the vessel, assessing blood flow quantitatively in the vessel by obtaining a value that correlates to blood flow in said vessel, comparing the obtained value with a reference value, and determining whether the individual has compromised blood flow based on the results of the comparison. The invention also provides for methods of diagnosing atherosclerotic and ischemic heart diseases using UTP, a derivative thereof, or a salt thereof, as well as methods for inducing maximal hyperemia for diagnostic purposes.Type: ApplicationFiled: August 10, 2010Publication date: April 14, 2011Inventor: Jaya Brigitte Rosenmeier
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Publication number: 20110085978Abstract: This invention provides novel quinolinylamide derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.Type: ApplicationFiled: March 13, 2009Publication date: April 14, 2011Applicant: NeuroSearch A/SInventors: Dan Peters, Lars Christian Rønn, Karin Sandager Nielsen, Jørgen Scheel-Krüger
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Publication number: 20110085979Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.Type: ApplicationFiled: May 21, 2009Publication date: April 14, 2011Applicants: Ramot at Tel-Aviv University Ltd., University of Utah Research FoundationInventors: Ronit Satchi-Fainaro, Ehud Segal, Jindrich Kopecek, Pavla Kopeckova, Huaizhong Pan
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Publication number: 20110085980Abstract: The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.Type: ApplicationFiled: September 28, 2010Publication date: April 14, 2011Applicant: The Board of Trustees of The Leland Stanford Junior UniversityInventors: Jason Dugas, Ben A. Barres
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Publication number: 20110085981Abstract: The present disclosure discloses simple and efficient glycan- or carbohydrate-based processes or methods for the rapid identification of biological markers and therapeutic targets especially glycan-related targets of infectious diseases, cancers, autoimmune diseases, allergies, inflammation, toxicity, obesity and/or other disorders of humans, animals, plants and other organisms. Therefore, novel methods and products for the diagnosis, prevention, and treatment of such diseases obtainable based on these therapeutic targets can be developed.Type: ApplicationFiled: October 8, 2010Publication date: April 14, 2011Inventor: Huiru Wang
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Publication number: 20110085982Abstract: The present invention provides a human triple-negative breast cancer cell line designated DKAT. The DKAT cell line has a marker profile of high expression of Snail-1 and Snail-2 (Slug); and a p53 mutation in exon 8 at codon 273 (CGT>CAT). The present invention further provides methods of using the DKAT cell line.Type: ApplicationFiled: October 8, 2010Publication date: April 14, 2011Inventors: Victoria L. Seewaldt, Nicholas C. D'Amato, Julie H. Ostrander
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Publication number: 20110085983Abstract: The present invention provides liquid chromatography-mass spectrometry methods and kits for the specific, sensitive and rapid detection as well as quantitation of free amino acids in samples following High Pressure Liquid Chromatography (HPLC) separation.Type: ApplicationFiled: October 12, 2010Publication date: April 14, 2011Applicant: The Boards of Trustees of the Leland Stanford Junior UniversityInventors: Anthony Le, Tina Cowan
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Publication number: 20110085984Abstract: The invention provides a drug product for treating radiation exposure comprising, a drug in a dosage form; and packaging for the drug together with a package insert or label that includes information about the drug's efficacy, where the information about the drug's efficacy is obtained at least in part from methods described in the disclosure.Type: ApplicationFiled: December 14, 2010Publication date: April 14, 2011Inventors: James M. Frincke, Armando Garsd
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Publication number: 20110085985Abstract: The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents.Type: ApplicationFiled: May 28, 2009Publication date: April 14, 2011Inventors: James C. Barrow, Scott Harrison, James Mulhearn, Cyrille Sur, David L. Williams, Scott Wolkenberg
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Publication number: 20110085986Abstract: The current invention provides Progastrin peptides that specifically bind Annexin A2 overexpressed by epithelial cancers. The invention includes isolated homing Progastrin peptides conjugated to an imaging agent and methods of using the same for the diagnosis of epithelial cancers. Also encompassed are Progastrin peptides conjugated to cytotoxic agents such as Camptothecin, Doxorubicin, Paclitaxel and derivatives thereof, and methods of treating epithelial cancer using the same.Type: ApplicationFiled: October 13, 2010Publication date: April 14, 2011Inventor: Pomila Singh
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Publication number: 20110085987Abstract: The preparation method of the magnetic nanoparticle (MNP) includes steps of: (a) reacting folic acid (FA) with Pluronic F127 (PF127) to form FA-PF127; (b) reacting poly(acrylic acid) (PAA) with FeCl3 to form PAA-bound iron oxide (PAAIO); and (c) reacting FA-PF127 with PAAIO via N-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDAC) mediation to form FA-PF127-PAAIO. FA-PF127-PAAIO is nontoxic and shows the superparamagnetic property at room temperature. The Nile red-loaded FA-PF127-PAAIO can be performed as the chemotherapy agent and the contrast agent on magnetic resonance (MR) imaging.Type: ApplicationFiled: January 27, 2010Publication date: April 14, 2011Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Li-Fang Wang, Jia-Jyun Lin, Jenn-Shing Chen, Shih-Jer Huang, Jyun-Han Ka, Yun-Ming Wang, Ting-Jung Chen
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Publication number: 20110085988Abstract: There is provided herein, in one specific embodiment, silicone composition(s) comprising unique combination(s) of silicone polymer and alkyltrisiloxane(s) which can produce silicone composition(s) with lower solids content than silicone compositions that use other than alkyltrisiloxane(s); while still maintaining a desirable viscosity.Type: ApplicationFiled: December 17, 2010Publication date: April 14, 2011Applicant: Momentive Performance Materials, Inc.Inventors: Benjamin Falk, Judith Kerschner, Gerald J. Murphy, John Nicholson
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Publication number: 20110085989Abstract: This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathogen and the causative agent of dental caries.Type: ApplicationFiled: March 24, 2010Publication date: April 14, 2011Inventors: Jian He, Randal H. Eckert, Fengxia Qi, Maxwell H. Anderson, Wenyuan Shi