Abstract: A polymer blend includes a first random copolymer of propylene and one or more C2-C20 ?-olefins other than propylene having a melting point of above 116° C. and up to about 145° C. and which constitutes from about 60 weight percent to about 95 weight percent of the composition, and a second random copolymer of propylene and one or more C2-C20 ?-olefins other than propylene having a melting point of from about 70° C. to no more than 116° C. and which constitutes from about 5 weight percent to about 40 weight percent of the composition. The polymer blend includes a xylene soluble fraction having a weight average molecular weight of above about 100 kg/mol and an intrinsic viscosity of above about 1.0 dl/g.

Abstract: A seal for a valve for use in a pharmaceutical dispensing device, which seal is formed from a thermoplastic elastomer including a propylene component with isotactic crystallinity.

Abstract: A process of preparing a telechelic polyolefin is disclosed by performing steps 1a, 2, and 1b in this order in the presence of an olefin polymerizing catalyst and subsequently performing step 3 if necessary. Step 1a involves reacting the olefin polymerizing catalyst with a polar-group-containing olefin (C). Step 2 involves reacting the resultant compound of step 1a with at least one olefin (D) selected from ethylene and olefins having 3 to 20 carbon atoms n times wherein n is an integer of 1 or more, provided that when n is an integer of 2 or more, the olefins (D) used in the respective contact operations are different in kind or composition. Step 1b involves reacting the resultant compound of step 2 with the same or different polar-group-containing olefin (C). Step 3 involves chemically converting the Y? group in the general formula (II) to a different group.

Abstract: The present invention relates to modified comb copolymers comprising special structural units, which are produced by converting SMA resins and optionally special copolymers with an AB block copolymer structure with a mixture of at least one polyalkylene oxide monoamine and at least one amino alcohol, with a mixture of at least one polyalkylene oxide monoamine and at least one N,N-disubstituted diamine or a mixture of at least one polyalkylene oxide monoamine, at least one N,N-disubstituted diamine and at least one polymer selected from the group comprising monohydroxy-terminated polyalkylene oxides, monohydroxy-terminated polyesters and monohydroxy-terminated block copolymers comprising polyalkylene oxide and polyester blocks, and their monohydroxy-terminated side chains are converted to phosphoric acid ester groups or their N,N-disubstituted amino-terminated side chains are converted to quaternary ammonium salts, and their use as wetting and dispersing agents.

Abstract: Implantable medical devices and methods including blends of biodegradable polymers are disclosed herein. The polymer blends include a continuous phase in which the polymer chains are oriented along an axis. Such polymer blends can exhibit properties such as improved toughness that can be desirable for use in medical devices.

Abstract: Biodegradable polymers formed from biodegradable polyester-based prepolymers, to which ring-structured anhydrides which have different hydrophobicities have been connected, and which are either coupled to form linear thermoplastic polyester anhydrides or cross-linked to form network-structured polyester anhydrides. It is possible to adjust widely the degradation rate and mechanism of the polymers and thus they can be used, for example, in the controlled dosing of pharmaceutical ingredients, for tissue technological applications, in surgery and in bioactive composites.

Abstract: The present invention has its object to provide a pressure sensitive adhesive composition which can be applied using no organic solvent and which manifests excellent pressure sensitive adhesion characteristics. This object can be achieved by a pressure sensitive adhesive composition which comprises, as essential constituents, the following: (A) a hydrolyzable silyl group-containing organic polymer containing at least 1.3 hydrolyzable silyl groups per molecule and having a number average molecular weight of 15,000 to 100,000; (B) a hydrolyzable silyl group-containing organic polymer containing 0.3 to 1.3 hydrolyzable silyl groups per molecule and having a number average molecular weight of 500 to 15,000; and (C) a tackifier resin.

Abstract: Provided is a curable polyorganosiloxane composition which advantageously forms a cured product suitable for LED or optical lens, wherein the cured product has excellent light transmission properties in a short wavelength region, i.e., in the blue to ultraviolet region and is unlikely to suffer yellowing due to exposure to heat.

Abstract: A method for treating at least one interior surface (for example, a bed wall) of a fluidized bed polymerization reactor system, including by applying a solution catalyst (preferably at least substantially uniformly and in liquid form) to each surface, and optionally (where a catalyst component of the solution catalyst comprises at least one chromium containing compound) oxidizing at least some of the applied chromium containing compound in a controlled manner.

Abstract: A process for preventing or reducing polymer agglomeration and/or accumulation on or around the gas distribution grid in an olefin polymerization, fluidized-bed reactor. The process involves introducing one or more scouring balls into the reactor above the gas distribution grid, and carrying out olefin polymerization in the presence of the scouring balls. Also disclosed is a process for polymerizing olefins in a fluidized-bed reactor with reduced polymer agglomeration and/or accumulation on the gas distribution grid.

Abstract: A continuous gas phase circulating bed reactor, including: a riser for contacting a catalyst and a first gas composition comprising an olefin to form a polyolefin under fast-fluidization regime or a dilute-phase pneumatic conveying regime conditions; a downer for contacting the catalyst and a second gas composition comprising an olefin to form additional polyolefin under fast fluidization regime or a dilute-phase pneumatic conveying regime conditions; and a transport section for conveying at least a portion of the catalyst, polyolefin, and additional polyolefin from the downer to the riser. Also disclosed is a polymerization process using such a circulating bed reactor.

Abstract: Disclosed herein are various processes, including continuous fluidized-bed gas-phase polymerization processes for making a high strength, high density polyethylene copolymer, comprising (including): contacting monomers that include ethylene and optionally at least one non-ethylene monomer with fluidized catalyst particles in a gas phase in the presence of hydrogen gas at an ethylene partial pressure of 100 psi or more and a polymerization temperature of 120° C. or less to produce a polyethylene copolymer having a density of 0.945 g/cc or more and an ESCR Index of 1.0 or more wherein the catalyst particles are prepared at an activation temperature of 700° C. or less, and include silica, chromium, and titanium.

Abstract: Systems and methods for removing a volatile catalyst poison from a liquid hydrocarbon are provided. In one embodiment, a process vent (106) can be introduced to a vent recovery system (108) to provide a recycle gas (110). A first portion of the recycle gas (112) and a liquid hydrocarbon (102) can be introduced to a stripper column (104) to provide a stripper vent gas (114) and a degassed liquid hydrocarbon (116) that can be introduced to a polymerization process.

Abstract: A discharge system for removing a solid/gas mixture from a fluidized bed pressure vessel is provided. The discharge system includes a fluidized bed pressure vessel, a settling vessel, a transfer vessel, discharge line, primary discharge valve, and primary exit valve. Also in included is a method to operate the discharge system. The method includes transferring a solid/gas mixture from a fluidized bed pressure vessel to a settling vessel, transferring the solids to a transfer vessel, and then emptying the transfer vessel.

Abstract: A process for forming a high molecular weight, multi-block copolymer comprising two or more chemically distinguishable segments or blocks, the process comprising polymerizing one or more olefin monomers in the presence of a chain shuttling agent and a catalyst composition comprising two or more olefin polymerization catalysts capable of preparing polymers having differing chemical or physical properties under equivalent polymerization conditions, or a catalyst composition comprising at least one olefin polymerization catalyst containing multiple active catalyst sites capable of preparing polymers having differing chemical or physical properties.

Abstract: Provided are a novel transition metal complex where a monocyclopentadienyl ligand to which an amido or alcoxy group is introduced is coordinated, a method of synthesizing the same, and olefin polymerization using the transition metal complex. Compared to a conventional transition metal complex having a silicon bridge and an oxido ligand, the transition metal complex has a phenylene bridge, so that a monomer easily approaches the transition metal complex in terms of structure and a pentagon ring structure of the transition metal complex is stably maintained. The catalyst composition including the transition metal complex is used to synthesize a polyolefin copolymer having a very low density less than 0.910 g/cc.

Abstract: The present invention provides an ethylene polymer that has excellent fluidity and moldability as well as gives a molded product having excellent mechanical strength. The ethylene polymer of the present invention contains 0.02 to 1.50 mol % of a constitutional unit derived from ?-olefin having 6 to 10 carbon atoms, and has the density of 945 to 975 kg/m3, which satisfies both of the following requirements [1] and [2] simultaneously: [1] in CFC, all the components having a molecular weight of 100,000 or more are eluted at a temperature of 85° C. or higher; and [2] the components eluted at a temperature of 80° C. or lower account for up to 5% of all the components eluted in CFC.

Abstract: A propylene polymer composition having a Flexural modulus lower than 500 MPa, a total ethylene content from 9 to 30% by weight, a xylene soluble fraction at room temperature higher than 25% by weight, a melting temperature measured by DSC (Tm° C.) from 130 to 150° C. and a ratio between the weight of xylene soluble fraction at 25° C. and the hexane soluble fraction determined on plaque (100 ?m) of higher than 4.

Abstract: A siloxane resin having the formula: (HSiO3/2)a(RSiO3/2)b(SiO4/2)c where R is Z, Z(CH2)n or ZO(CH2)n where Z is a phenyl or substituted phenyl group; n has a value of 1 to 6, a has value of 0.01 to 0.7, b has a value of 0.05 to 0.7, c has a value of 0.1 to 0.9 and a+b+c?1. The siloxane resins are useful in anti-reflective coating compositions.

Abstract: The present invention is directed to a coating composition comprising polyurea formed from a reaction mixture comprising: (a) a first component comprising isocyanate, wherein said isocyanate comprises an isocyanate functional prepolymer formed from a reaction mixture comprising isocyanate and a material comprising a phosphorus-containing polyol; and (b) a second component comprising an amine.

Abstract: There is provided an aromatic polyester suitable for optical applications, which has not only high heat resistance and transparency, but also enhanced fluidity at a relatively low molding temperature of less than 300° C. despite its high molecular weight to be substantially colorless after the molding process. The aromatic polyester of the present invention comprises polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof; wherein the polyhydric phenol residues comprise polyhydric phenol residues represented by Formula (I): —O—Ar—W1x—Ar—O— and/or Formula (II): —O—Ar—O—, and bulky polyhydric phenol residues represented by Formula (III): —O—Ar—W2—Ar—O—; wherein the molar ratio of the polyhydric phenol residues represented by Formula (I) and/or Formula (II) to the polyhydric phenol residues represented by Formula (III) is in the range of 100:0 to 30:70 (exclusive of 100:0).

Abstract: Disclosed is a polymer having excellent solvent resistance which can be produced by using a polycarbonate diol having a repeating unit represented by the formula (1) and/or (2), having a hydroxyl group at both termini, and having a number average molecular weight of from 300 to 50,000: wherein R1 represents a linear or branched hydrocarbon group having 2 to 50 carbon atoms; and n represents an integer of 2 to 50, wherein R2 represents a linear or branched hydrocarbon group having 10 to 50 carbon atoms.

Abstract: This invention provides a coating composition for use on a food-contact surface of a container (e.g., a food or beverage can) that includes a polymer having one or more segments of Formula I: —O—Ar—Rn—C(O)—O—R1—O—C(O)—Rn—Ar—O— wherein each Ar is independently a divalent aryl group (i.e., an arylene group) or heteroarylene group; R1 is a divalent organic group; each R is independently a divalent organic group; and n is 0 or 1. Containers comprising the polymer and methods of making such containers are also provided.

Abstract: An approach is presented for designing a polymeric layer for nanometer scale thermo-mechanical storage devices. Cross-linked polyimide oligomers are used as the recording layers in atomic force data storage device, giving significantly improved performance when compared to previously reported cross-linked and linear polymers. The cross-linking of the polyimide oligomers may be tuned to match thermal and force parameters required in read-write-erase cycles. Additionally, the cross-linked polyimide oligomers are suitable for use in nano-scale imaging.

Abstract: An organic thin film transistor comprising a semiconductor layer containing a thiophene oligomer which has a thiophene ring having a substituent and a partial structure constituted by directly connected two or more thiophene rings each having no substituent, and contains three to forty thiophene rings per molecule.

Abstract: A PBI compound includes imidazole nitrogens at least a portion of which are substituted with a moiety containing a carbonyl group, the substituted imidazole nitrogens being bonded to carbon of the carbonyl group. At least 85% of the nitrogens may be substituted. The carbonyl-containing moiety may include RCO—, where R is alkoxy or haloalkyl. The PBI compound may exhibit a first temperature marking an onset of weight loss corresponding to reversion of the substituted PBI that is less than a second temperature marking an onset of decomposition of an otherwise identical PBI compound without the substituted moiety. The PBI compound may be included in separatory media. A substituted PBI synthesis method may include providing a parent PBI in a less than 5 wt % solvent solution. Substituting may use more than 5 equivalents in relation to the imidazole nitrogens to be substituted.

Abstract: The present disclosure generally relates to peptides having antiviral properties. More particularly, the invention relates to peptides exhibiting activity against influenza viruses, to pharmaceutical compositions comprising the peptides, and to methods of using the peptides to prevent and/or treat influenza viral infections.

Abstract: The present invention relates to isolated Porphyromonas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO. 110; SEQ. ID. NO. 111; SEQ. ID. NO. 112; SEQ. ID. NO. 113; SEQ ID NO: 120; SEQ. ID. NO. 123; SEQ. ID. NO. 124; SEQ. ID. NO. 125; SEQ. ID. NO. 130; SEQ. ID. NO. 131; SEQ. ID. NO. 132; SEQ. ID. NO. 133; SEQ. ID. NO. 135; SEQ. ID. NO. 136; SEQ. ID. NO. 137; SEQ. ID. NO. 138; SEQ. ID. NO. 143; SEQ. ID. NO. 144; SEQ. ID. NO. 145; SEQ. ID. NO. 146; SEQ. ID. NO. 147; SEQ. ID. NO. 148; and amino acid sequences at least 95% identical thereto.

Abstract: Disclosed is gluten having good dispersibility in water. Also disclosed is a method for producing active gluten, a gluten-containing food or a gluten gel efficiently by using a gluten dispersion solution. Further disclosed is a method for producing a gluten hydrolysate efficiently by preparing a gluten dispersion solution in a simple manner and hydrolyzing the dispersion solution. Gluten, which normally forms an aggregate in water, can be dispersed readily by mixing gluten with a water-soluble polysaccharide containing galacturonic acid. The gluten dispersion solution thus prepared can be used to produce active gluten, a gluten-containing food or a gluten gel efficiently, and can be also used to prepare a gluten hydrolysate in a simple manner, efficiently and stably.

Abstract: The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

Abstract: Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g.

Abstract: Pharmaceutical compositions containing modified fusion proteins of transferrin and therapeutic proteins or peptides with increased serum half-life or increased serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, but does exhibit binding to iron and/or the transferrin receptor. Such fusion proteins may be administered orally.

Abstract: The present invention provides a process for producing a comb polymer comprising the steps of: a) providing: (i) (w+z) molar equivalents of a monomer; (ii) one molar equivalent of an initiator compound of formula (IX), wherein B3 represents a halogen, B2 represents H or a halogen, Y1 represents a group capable of attaching the residue of an antibody or fragment thereof or capable of being converted into such a group, L represents a linker group, y is 1, 2 or 3, w is at least 1 and z is 0 or greater; (iii) a catalyst capable of catalysing the polymerization of a plurality of the monomers to produce the comb polymer; and b) causing the catalyst to catalyse, in combination with the initiator, the polymerization of a plurality of the monomers (i) to produce the comb polymer.

Abstract: The present invention provides for chimeric proteins comprising a MUC1 extracellular (MUC1-EC) polypeptide and a carrier polypeptide that function as traps for MUC1 ligands.

Abstract: An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.

Abstract: The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity chromatography process without the use of an in-process tangential flow filtration step.

Abstract: Compounds and methods are provided for a single-step covalent attachment of a label to a molecule comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture containing the molecule, under conditions wherein the labeling reagent has reactivity with the molecule thereby forming a covalent bond.

Abstract: Methods and compositions for expressing a gene or nucleotide sequence of interest are provided. The compositions include an expression cassette that includes a synthetic enhancer, a transthyretin promoter, and a nucleotide sequence operably under the control of the synthetic enhancer and the transthyretin promoter. The expression cassette may be used in an adeno-associated viral (AAV) vector, such as a self-complementary AAV vector.

Abstract: This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exo-specificity and/or thermostability. Some embodiments of the invention relate to said polypeptides and nucleic acids and their uses as non-maltogenic exoamylases in producing food products.

Abstract: Methods for identifying one or more amino acid substitutions in a Rubisco large subunit polypeptide (variant) that confer increased Rubisco activity in a unicellular photosynthetic organism and transferring those substitutions to a Rubisco large subunit polypeptide of a higher plant cell are described herein. Methods and compositions for modulating plant productivity using the modified Rubisco large subunit polypeptide variants are provided. The Rubisco large subunit sequences are used in a variety of methods including increasing plant productivity in a plant. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided.

Abstract: This invention provides a plant senescence-inducible promoter and its relevant recombinant plasmid and transgenic plant.

Abstract: Provided is a novel plant regulatory sequence active in trichomes which is derived from the TR4 gene of wild tomato (L. hirsutum) and which comprises a nucleic acid at least 80% identical to SEQ ID NO:26. Also provided are nucleic acid constructs and methods of using same for directing expression of an exogenous polynucleotide sequences in trichomes and transgenic plant cells and transgenic plants which comprise the nucleic acid constructs.

Abstract: Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.

Abstract: The present invention pertains to the use of paranemic crossover motifs for RNA self-assembly, and the use of those self-assembled complexes to carry out analytical methods, and as a basis for the creation of sensors. The invention includes RNA monomeric units comprising an RNA having a binding domain that is adapted to self-assemble paranemically so as to form an RNA complex with another RNA, the binding domain of the RNA monomeric unit comprising an aptameric portion bound to a fluorophore. The invention also includes RNA complexes comprising a target RNA molecule and at least one of these monomeric units which self-assemble paranemically so as to form the RNA complex comprising an aptameric portion. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

Abstract: The disclosed invention pertains to improved oligonucleotide manufacturing methods, including novel support compositions that are optionally labeled, their methods of preparation and use. The compositions and methods are particularly well suited for high throughput oligonucleotide manufacturing in that the automated support recognition facilitates loading of the wells with the proper supports. In addition, the labeled supports can be used to confirm that each well of a multi-well plate, such as a 96 or 384 well plate, was properly loaded.

Abstract: Provided are synthetic polysaccharide antigens (SPAs) with anti-inflammatory or inflammatory immunomodulatory properties, depending on their structure. Also provided are compositions comprising these SPAs, and methods of using these SPAs and compositions to either prevent or treat inflammatory pathologies, or diseases or conditions susceptible to treatment with inflammatory immunomodulators, by using appropriate SPAs.

Abstract: Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/?-catenin signaling pathway, and serve to reduce ?-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

Abstract: The present invention provides dipyrrin substituted porphyrinic macrocycles, intermediates useful for making the same, and methods of making the same. Such compounds may be used for purposes including the making of molecular memory devices, solar cells and light harvesting arrays.

Abstract: A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at ?30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated.

Abstract: An improved method is provided for preparing a mixed solvate of olanzapine/water/tetrahydrofuran in a proportion of 1:1:1/2. Said improvement is characterised in that said mixed solvate is basically prepared by means of methylation of the N-desmethylolanzapine with dimethyl sulphate, using tetrahydrofuran and water as solvents.