Patents Issued in March 6, 2014
-
Publication number: 20140065030Abstract: The present invention is directed toward a colorimetric detection kit comprising a unit containing chemical reagents and a sample collector for collecting a sample analyte from a surface and a separate unit for visualizing a possible reaction of the chemical reagent and sample, the unit holding the chemical reagents and sample collector being placeable on the visualization unit, whereby when the chemical reagents are released, they are directed onto the sample collector for reaction and the reacted reagents absorbed on a visualization media, such that the presence of a specified analyte in the sample results in a color change in the visualization media.Type: ApplicationFiled: October 23, 2012Publication date: March 6, 2014Applicant: U.S. Army Research Development and Engineering CommandInventor: U.S. Army Research Development and Engineerin
-
Publication number: 20140065031Abstract: The invention relates to a container, tube or chemical apparatus, in particular for the construction of chemical apparatus for storing or for transporting aggressive storage media, comprising a solid inner layer with the inner side of which the storage medium can come into contact and which is made of a thermoplastic that is resistant to the storage medium, comprising an adhesion-promoting layer applied to the outer side of the inner layer, which is made of a textile sheet-like structure, and comprising a carrier layer applied to the outer side of the adhesion-promoting layer for providing mechanical support to the layer structure, wherein between the inner layer and the outer layer an indicator layer is provided, the material of the indicator layer being discolored by components of the storage medium which permeate through the inner layer.Type: ApplicationFiled: May 2, 2012Publication date: March 6, 2014Applicant: Simona AGInventor: Achim K.E. Litzenburger
-
Publication number: 20140065032Abstract: Provided is a specimen analysis apparatus. The specimen analysis apparatus includes an image photographing unit photographing an identification code disposed on a kit for specimen analyzing and a specimen reaction result reacting by injecting a specimen into the kit for specimen analyzing and a main body on which the image photographing unit is mounted. The image photographing unit photographs the identification code and the specimen reaction result with a time difference.Type: ApplicationFiled: August 29, 2013Publication date: March 6, 2014Applicant: INFOPIA CO., LTD.Inventors: Byeong Woo BAE, Sung Dong LEE, Rae Ho KANG, Ji Hun SHIN, Ju Pyo HONG
-
Publication number: 20140065033Abstract: Provided is a case for specimen analyzing kit. The case includes a cover unit comprising a put-in part through which a specimen is putted and a result exposing part exposing a reaction result between the specimen and a reaction pad to the outside, a support unit coupled to the cover unit to define a predetermined inner space, and a plurality of put-in holes passing through the put-in part to introduce the specimen into the inner space.Type: ApplicationFiled: August 29, 2013Publication date: March 6, 2014Applicant: INFOPIA CO., LTD.Inventors: Byeong Woo BAE, Sung Dong LEE, Rae Ho KANG, Ji Hun SHIN, Ju Pyo HONG
-
Publication number: 20140065034Abstract: Lab-on-a-chip microfluidic devices having micro-channels able to withstand an internal channel pressure of more than 4,000 psi are described. The micro-channels have rounded cross-sections that prevent turbulent flow within a fluid conveyed within the channel. The channel may have serpentine-shaped length extending between a channel inlet and a channel outlet, the channel thereby being of sufficient length to observe both the stationary and moving phases of the fluid in a chip having a sufficiently small footprint that it is suitable for incorporation into a miniaturized spectrometer. Methods of fabricating lab-on-a-chip microfluidic devices are described by etching recesses in chip substrates such that a first substrate recess mirrors a second substrate recess in an opposed orientation, aligning the substrates such the recesses cooperatively define a micro-channel having a rounded cross-section, and bonding the substrates to define a smooth-walled micro-channel.Type: ApplicationFiled: August 31, 2012Publication date: March 6, 2014Inventors: Yun Zheng, Edward Wassell, Manuel Balvin, Stephanie Getiy
-
Publication number: 20140065035Abstract: The present invention relates to a method for manufacturing a microvalve device of a lab-on-a-chip by interposing a polyvinylidene chloride film between upper and lower substrates, each of which is produced by injection molding of a rigid polymer resin, and heating and pressurizing the resultant structure. The present invention also relates to a microvalve device manufactured by the method. According to the method of the present invention, each of the upper and lower substrates can be produced by injection molding of a rigid polymeric material, thus being appropriate for mass production in a short time. Excellent thermal bonding properties between the polyvinylidene chloride film and the substrates enable the formation of the rigid substrate/film membrane/rigid substrate structure in an easy and reliable manner, which shortens the time required to manufacture the microvalve device. Therefore, the method of the present invention is suitable for the mass production of labs-on-a-chip.Type: ApplicationFiled: April 18, 2012Publication date: March 6, 2014Applicant: BIO FOCUS CO., LTD.Inventor: Mun-tak Son
-
Publication number: 20140065036Abstract: A universal tray holder assembly on a CTC prep and load instrument is disclosed. The assembly contains sample tray and a tray support block attached directly to the sample tray, support legs attached to the tray support block at a first edge of the support legs, and clamps attached to the support leg at a second edge that is distal to the first edge. The sample tray is reversibly detachable from the tray support block when the clamps are attached to the x-beam rail, and removal and subsequent replacement of the sample tray onto the support block results in no change in the x and y positions of any sites on the sample tray relative to the positions before tray removal. The invention saves time during installation and removal because the operator does not need access to the back of the chromatograph instrument. Positions do not need to be re-taught if access to underneath the sample tray is needed. Trays can be changed without the need for purchasing a different tray holder.Type: ApplicationFiled: September 5, 2013Publication date: March 6, 2014Inventor: Matthew Orcutt
-
Publication number: 20140065037Abstract: There is provided a hydrometallurgical process of recovering indium and gallium values from mixtures thereof with other metal values for example recycled and scrap solar panel cells which comprises subjecting the mixture to strongly oxidizing acid conditions, preferably via the simultaneous addition of sulfuric acid and hydrogen peroxide to the leach vessel, so as to form indium and gallium salt species of at least the major proportion of the indium and gallium values in the mixture, extracting the indium and gallium values with an organic extractant by adjusting the pH so as to extract individually the indium and gallium values with the organic extractant, stripping indium and gallium values from the extractant using an acid and an alkaline solution respectively and recovering the indium and gallium values.Type: ApplicationFiled: November 22, 2011Publication date: March 6, 2014Applicant: MOLYCORP MINERALS CANADA ULCInventor: Cesare G. Ferron
-
Publication number: 20140065038Abstract: There are provided processes for extracting aluminum ions from aluminous ores and for preparing alumina. Such processes can be used with various types of aluminous ores such as aluminous ores comprising, for example, various types of metals such as Fe, K, Mg, Na, Ca, Mn, Ba, Zn, Li, Sr, V, Ni, Cr, Pb, Cu, Co, Sb, As, B, Sn, Be, Mo, or mixtures thereof.Type: ApplicationFiled: November 7, 2013Publication date: March 6, 2014Applicant: ORBITE ALUMINAE INC.Inventors: Richard BOUDREAULT, Serge ALEX, Fabienne BIASOTTO
-
Publication number: 20140065039Abstract: A method of extracting an alkali metal and/or an alkaline earth metal from a mineral including an alkali metal and/or an alkaline earth metal, or a rock containing the mineral, the method including contacting the mineral, with an aqueous composition including formic acid, and to their use in carbon sequestration.Type: ApplicationFiled: November 25, 2011Publication date: March 6, 2014Inventors: Bogdan Z. Dlugogorski, Manisha Ghoorah, Eric M. Kennedy
-
Publication number: 20140065040Abstract: A process for separating off acid gases from a water-comprising fluid stream wherein the water-comprising fluid stream is contacted in an absorption zone with an absorbent, producing a deacidified fluid stream and an acid gas-loaded absorbent; the deacidified fluid stream is contacted in a scrubbing zone with an aqueous scrubbing liquid, producing a deaminated, deacidified fluid stream and an amine-loaded scrubbing liquid which is cooled, producing an absorber top condensate; the loaded absorbent is passed into a desorption zone producing a regenerated absorbent and desorbed acid gases; the regenerated absorbent is returned to the absorption zone in order to form an absorbent circuit, to which the amine-loaded scrubbing liquid and the absorber top condensate are introduced; and the desorbed acid gases are conducted through an enrichment zone and the acid gases exiting at the top of the enrichment zone are cooled, producing a desorber top condensate.Type: ApplicationFiled: September 5, 2013Publication date: March 6, 2014Applicant: BASF SEInventors: Torsten Katz, Karsten Bartling
-
Publication number: 20140065041Abstract: Methods and systems include an operation to interpret a face-plugging index and/or a reduction in an expected oxidation efficiency of an oxidation catalyst disposed in an internal combustion engine aftertreatment system, and in response to the face-plugging index or the reduction oxidation efficiency reaching a threshold value, an operation to provide a catalyst element reversal command.Type: ApplicationFiled: August 28, 2013Publication date: March 6, 2014Applicant: Cummins Emission Solutions, Inc.Inventors: Tamas Szailer, Junhui Li, Aleksey Yezerets, Ross Berryhill, Matthew Henrichsen, Nathan Ottinger
-
Publication number: 20140065042Abstract: A three way catalyst includes an extruded solid body having by weight: 10-100% of at least one binder/matrix component; 5-90% of a zeolitic molecular sieve, a non-zeolitic molecular sieve or a mixture of any two or more thereof; and 0-80% optionally stabilised ceria. The catalyst also includes at least one precious metal and optionally at least one non-precious metal, wherein: (i) the at least one precious metal is carried in one or more coating layer(s) on the body surface; (ii) at least one metal is present throughout the body and at least one precious metal is carried in one or more coating layer(s) on a body surface; or (iii) at least one metal is present throughout the body, is present in a higher concentration at a body surface, and at least one precious metal is carried in one or more coating layer(s) on the body surface.Type: ApplicationFiled: November 13, 2013Publication date: March 6, 2014Applicant: Johnson Matthey Public Limited CompanyInventors: Paul Joseph Andersen, Ralf Dotzel, Kwangmo Koo, Rainer Leppelt, Jörg Werner Münch, Jeffery Scott Rieck, Hubert Schedel, Duncan John William Winterborn, Todd Howard Ballinger, Julian Peter Cox
-
Publication number: 20140065043Abstract: The purpose of the present invention is to provide an oxidation catalyst for exhaust gas purification having high durability and a method for producing the catalyst. The purpose is achieved by an oxidation catalyst for exhaust gas purification containing a refractory inorganic oxide, and a catalyst component and a metal component, which are supported on the refractory inorganic oxide, wherein the catalyst component is platinum, or platinum and palladium, and the metal component is one or more selected from the group consisting of magnesium, calcium, strontium and barium.Type: ApplicationFiled: March 21, 2012Publication date: March 6, 2014Applicants: UMICORE SHOKUBAI USA INC., UMICORE SHOKUBAI JAPAN CO., LTDInventors: Naohiro Kato, Yosuke Goto, Yuta Akasaka
-
Publication number: 20140065044Abstract: Ammonia oxidation catalyst being superior in heat resistance and capable of suppressing by-production of N2O and leakage of ammonia. The ammonia oxidation catalyst (AMOX) removes surplus ammonia, in selectively reducing nitrogen oxides by adding urea or ammonia and using a selective catalytic reduction (SCR) catalyst, into exhaust gas, wherein the ammonia oxidation catalyst is made by coating at least two catalyst layers having a catalyst layer (lower layer) including a catalyst supported a noble metal element on a composite oxide (A) having titania and silica as main components, and a catalyst layer (upper layer) including a composite oxide (C) consisting of tungsten oxide, ceria, and zirconia, at the surface of an integral structure-type substrate, wherein a composition of the composite oxide (C) is tungsten oxide: 1 to 50% by weight, ceria: 1 to 60% by weight, and zirconia: 30 to 90% by weight.Type: ApplicationFiled: November 17, 2011Publication date: March 6, 2014Applicant: N.E. CHEMCAT CORPORATIONInventors: Tomoaki Ito, Toshinori Okajima, Makoto Nagata
-
Publication number: 20140065045Abstract: This invention pertains to processes for selectively oxidizing hydrogen cyanide contained in syngas using permanganate anion as an oxidant contained in an aqueous solution that is contacted with the syngas under certain conditions of temperature, pressure and duration of contact.Type: ApplicationFiled: November 13, 2013Publication date: March 6, 2014Applicant: COSKATA, INC.Inventor: RICHARD E. TOBEY
-
Publication number: 20140065046Abstract: The present invention relates to a method of cleaning a process gas containing sulphur dioxide the method including removing sulphur dioxide from the process gas by contacting the process gas with seawater to generate an at least partly cleaned process gas in a first gas cleaning device. In a second gas cleaning device, being arranged in direct fluid connection with the first gas cleaning device, the at least partly cleaned process gas having passed through the first gas cleaning device is cooled to condense water there from, thereby generating a process gas having a reduced content of water vapour. At least a part of the condensed water generated in the second gas cleaning device is passed to the first gas cleaning device. The present invention moreover relates to a gas cleaning system for cleaning of a process gas containing sulphur dioxide.Type: ApplicationFiled: September 4, 2013Publication date: March 6, 2014Applicant: ALSTOM Technology LtdInventors: Olaf STALLMANN, Gerhard Heinz
-
Publication number: 20140065047Abstract: In one embodiment, a catalyst for ozone oxidation of pollutant components dispersed in a gas is provided. The ozone oxidation catalyst has a porous body formed from a metal body, a ceramic, or polymeric fibers coated with metal. A catalytic noble metal composition is deposited on the surface of the porous body. The catalytic noble metal composition is formed from particles of a noble metal supported by a mesoporous molecular sieve.Type: ApplicationFiled: October 28, 2013Publication date: March 6, 2014Applicant: City University of Hong KongInventors: Kwan San Hui, Kwok Leung Tsui, Man On Fu
-
Publication number: 20140065048Abstract: A carbon nanotube array suitable for use in labeling is provided. The carbon nanotube array includes at least two different isotope-doped carbon nanotube sub-arrays. Each isotope-doped carbon nanotube sub-array includes a plurality of carbon nanotubes. The carbon nanotubes in different isotope-doped carbon nanotube sub-arrays are composed of different kinds of carbon isotopes.Type: ApplicationFiled: November 12, 2013Publication date: March 6, 2014Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITYInventors: LIANG LIU, KAI-LI JIANG, SHOU-SHAN FAN
-
Publication number: 20140065049Abstract: A fluidized bed reactor comprising a reaction column having a fluid portion; a gas inflow means for flowing a gas upwardly from the fluid portion of the reaction column; a particle feed means for feeding particles to the fluid portion of the reaction column; a cyclone capable of separating particles from the gas flowing upwardly from the fluid portion of the reaction column, the cyclone being located within the reaction column and being in communication with the gas flowing upwardly, wherein the cyclone comprises a cyclone body having an inlet, a gas outlet, and a particle drop port; and a particle discharge pipe having an upper part connected to the particle drop port of the cyclone body, and a lower part, wherein the particle discharge pipe is located substantially outside of the reaction column.Type: ApplicationFiled: August 26, 2013Publication date: March 6, 2014Applicant: Honeywell International Inc.Inventors: Terris Yang, Robert Johnson, Hsueh Sung Tung
-
Publication number: 20140065050Abstract: Systems, methods and compositions for the production of silicon nitride nanostructures are herein disclosed. In at least one embodiment, a carbon feedstock is preprocessed, combined with a silicon feedstock and annealed in the presence of a nitrogen containing compound to produce a silicon nitride nanostructure.Type: ApplicationFiled: August 2, 2011Publication date: March 6, 2014Applicant: CRL Energy LimitedInventor: Joan Bakalar
-
Publication number: 20140065051Abstract: A method for revitalizing worn and fatigued silicon carbide powder thermally reacted it continuously with a mixture of silicon oxide powder and/or carbon powder and a boron and carbon-containing additive in a non-oxidizing atmosphere at a temperature higher than 1850 degrees C. but lower than 2400 degrees C.Type: ApplicationFiled: June 21, 2013Publication date: March 6, 2014Inventors: Yoshihiro Kubota, Masahiro Mochizuki
-
Publication number: 20140065052Abstract: Acicular strontium carbonate particles are manufactured by introducing gaseous carbon dioxide into an aqueous solution or suspension of strontium hydroxide having a concentration of 1 to 20 wt. %, at a flow rate of 0.5 to 200 mL/min., relative to one gram of the strontium hydroxide, while stirring the solution or suspension in the presence of a dicarboxylic acid, in which the dicarboxylic acid comprises a divalent linear hydrocarbon group having one to four carbon atoms and carboxyl group bonded to each terminals, with the proviso that the linear hydrocarbon group may be substituted with one or more C1-6 alkyl groups, and thus carbonating the strontium hydroxide.Type: ApplicationFiled: February 15, 2012Publication date: March 6, 2014Applicant: UBE MATERIAL INDUSTRIES, LTD.Inventors: Fumio Okada, Takeshi Himoto, Masayuki Fujimoto
-
Publication number: 20140065053Abstract: An apparatus that separates and recovers CO2 from a CO2 absorbent that has absorbed CO2 includes a regeneration tower configured to apply heat to the CO2 absorbent that has absorbed CO2, configured to separate and remove CO2 from the CO2 absorbent, configured to exhaust CO2 gas, and configured to regenerate the CO2 absorbent, a plurality of compressors configured to compress the CO2 gas exhausted from the regeneration tower, a dehydration device provided between the plurality of compressors and configured to remove moisture from the compressed CO2, and a line configured to supply air or N2 gas into the dehydration device to preliminarily operate the dehydration device until a stable state is achieved before starting the compressor.Type: ApplicationFiled: September 6, 2012Publication date: March 6, 2014Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.Inventors: Taku Asano, Tatsuya Tsujiuchi, Richard Reinke
-
Publication number: 20140065054Abstract: An air revitalization apparatus and method simultaneously removes carbon dioxide, water vapor, and heat from air and produces oxygen gas, hydrogen gas, and concentrated carbon dioxide gas, does not require an explosion proof enclosure, and includes a fan configured to blow air into a first gas-liquid contactor, an electrochemical cell including first through fourth passages configured to emit hydrogen gas, permit a flow of a carbonate-hydroxide solution, permit a flow of carbonate-bicarbonate solution, and emit oxygen gas, respectively, the first and fourth passages separated by at least three gas-impermeable membranes, and a second gas-liquid contactor, where the first gas-liquid contactor, second passage, and a first pump are configured to circulate the carbonate-hydroxide solution therethrough, where the second gas-liquid contactor, third passage, and a second pump are configured to circulate the carbonate-bicarbonate solution therethrough, and where the output of the first passage is operationally coupledType: ApplicationFiled: August 30, 2013Publication date: March 6, 2014Applicant: Oceaneering International, Inc.Inventor: Gary Patrick Noyes
-
Publication number: 20140065055Abstract: The present invention relates to a method for producing carbon micro- and nano-coils using sulfur hexafluoride gas, wherein the carbon micro- and nano-coils are synthesized and grown on a ceramic substrate and sulfur hexafluoride is introduced during the synthesis of the carbon coils to control the geometry of the carbon coils. The invention also discloses a method of producing carbon micro- and nano-coils by synthesizing and growing the carbon coils on a substrate using a chemical vapor deposition system, wherein sulfur hexafluoride (SF6), acetylene (C2H2) and hydrogen (H2) gases are introduced into a chamber during synthesis of the carbon coil, and wherein the sulfur hexafluoride and acetylene gases are introduced alternately for predetermined amounts of time, or any one or more of the flow rate, time or time point of introduction of the sulfur hexafluoride, thereby controlling the shape, length and geometry of the carbon coils.Type: ApplicationFiled: October 17, 2012Publication date: March 6, 2014Applicant: SILLA UNIVERSITYInventor: Sunghoon KIM
-
Publication number: 20140065056Abstract: A graphite material for a negative electrode is provided which can suppress capacity degradation due to repeated charging and discharging cycles, storage in a charged state, and floating charging. A method of manufacturing a graphite material for a negative electrode of a lithium ion secondary battery is provided in which an atomic ratio H/C of hydrogen atoms H and carbon atoms C in the raw coke composition is in a range of 0.30 to 0.50 and a microstrength of the raw coke composition is in a range of 7 wt % to 17 wt %.Type: ApplicationFiled: April 19, 2013Publication date: March 6, 2014Inventors: Takashi SUZUKI, Noriyo ISHIMARU, Takashi OYAMA, Tamotsu TANO, Toshiyuki ODA, Ippei FUJINAGA, Tomoaki URAI, Seiji OKAZAKI, Katsuaki KURATA, Toshiaki HIRAMOTO, Akino SATO, Wataru ODA
-
Publication number: 20140065057Abstract: A novel system and method for degassing H2S and H2Sx from liquid sulfur (sulphur) is disclosed. The system includes a degassing vessel with a plurality of cells. The cells include a sparging gas mat with a perforated surface at the bottom of the cell to allow the release of air bubbles (or sparging gas) into the cells. A catalyst may be used during the process. As a result, hydrogen sulfide and hydrogen polysulfide are efficiently and effectively removed from the liquid sulfur.Type: ApplicationFiled: August 29, 2012Publication date: March 6, 2014Inventors: Casey J. Metheral, Leslie L. Lang, Jamsheed P. Irani, Cody J. Wohlers, Sergio A. De Paoli
-
Publication number: 20140065058Abstract: Provided are an apparatus for preparing a cathode active material precursor for lithium secondary batteries including a cylindrical outer chamber, an inner cylinder that has the same central axis as the outer chamber and is mounted to rotatably move along the central axis, an electric motor to transfer power to rotate the inner cylinder, a reactant inlet disposed on the outer chamber, to add reactants to a space between the outer chamber and the inner cylinder, and an outlet disposed in the outer chamber, to obtain reaction products after reaction in the space between the outer chamber and the inner cylinder, and a method for preparing a cathode active material precursor for lithium secondary batteries using the apparatus.Type: ApplicationFiled: September 6, 2012Publication date: March 6, 2014Applicants: University-Industry Cooperation Group of Kyung Hee University, LG CHEM, LTD.Inventors: ByungChun PARK, Woosik KIM, HoSuk SHIN, Soonho AHN, Hong Kyu PARK, Joon Hyun CHANG
-
Publication number: 20140065059Abstract: Disclosed are a catalyst for producing, from an alcohol, an olefin whose number of carbon atoms is at least one more than the number of carbon atoms of the alcohol, wherein at least the surface of the catalyst is substantially composed of zirconium oxide; a method for producing an olefin using the same; and so on.Type: ApplicationFiled: December 7, 2011Publication date: March 6, 2014Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, TOKYO INSTITUTE OF TECHNOLOGY, IDEMITSU KOSAN CO., LTD.Inventors: Tetsuo Suzuki, Takahiro Kakinuma, Hiroshi Ohashi, Masakazu Iwamoto
-
Publication number: 20140065060Abstract: The present invention relates to a compound of the general formula (I) wherein R1 represents a group selected from the list consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, linear or branched, saturated or mono- or polyunsaturated aliphatic carbon chain containing from two to ten carbon atoms, phenyl, and phenylacetylen, and wherein R2 and R3 independently of each other represent a group selected from the list consisting of Cl, I, methyl, phenyl, or phenylacetylene.Type: ApplicationFiled: August 29, 2013Publication date: March 6, 2014Applicants: Karlsruher Institut fur Technologie (KIT), BASF SEInventors: Wolfgang Gerlinger, Bernd Sachweh, Stefan Bräse, Mirja Enders, Thierry Müller, Gerhard Kasper, Martin Seipenbusch, Kun Gao, Matthias Faust, Linus Reichenbach
-
Publication number: 20140065061Abstract: The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core comprising one or more polymers and one or more active agents, and at least one layer of one or more lipids on the surface of the polymeric core; more specifically, the invention relates to the use of curcumin within such a lipid-polymer nanoparticle formulation for minimizing QT prolongation associated with curcumin in treatment of cancer.Type: ApplicationFiled: August 31, 2013Publication date: March 6, 2014Applicants: SignPath Pharma Inc., University of North Texas Health Science CenterInventors: Amalendu Prakash Ranjan, Anindita Mukerjee, Jamboor K. Vishwanatha, Lawrence Helson
-
Publication number: 20140065062Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.Type: ApplicationFiled: November 4, 2013Publication date: March 6, 2014Inventor: Bahram Memarzadeh
-
Publication number: 20140065063Abstract: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.Type: ApplicationFiled: May 15, 2013Publication date: March 6, 2014Inventors: Marna Williams, J. Yun Tso, Nicholas F. Landolfi, Gao Liu
-
Publication number: 20140065064Abstract: Monoclonal antibodies (MoAbs or mAbs) specific for ALPHA-ACTININ-4 antigens, hybridoma lines that secrete these ALPHA-ACTININ-4 mAbs, and the use of such mAbs to detect ALPHA-ACTININ-4 antigens, particularly those expressed by cancer cells are disclosed. Chimeric and humanized antibodies based upon these anti-ALPHA-ACTININ-4 mAbs, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment of cancer are also disclosed. Methods and kits for the immunodetection and immunotherapy of cells for samples which express ALPHA-ACTININ-4 antigens are additionally disclosed.Type: ApplicationFiled: December 23, 2011Publication date: March 6, 2014Inventor: Özge Alper
-
Publication number: 20140065065Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n (NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.Type: ApplicationFiled: November 6, 2013Publication date: March 6, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Bruce Fletcher Johnson, Randall Lee Carter, Michael James Rishel, Mark Christopher Patrick Darey, Tao Wu, Yang Yang, John Fitzmaurice Valliant, Karin Ann Stephenson
-
Publication number: 20140065066Abstract: The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.Type: ApplicationFiled: March 11, 2013Publication date: March 6, 2014Applicant: PURDUE RESEARCH FOUNDATIONInventor: PURDUE RESEARCH FOUNDATION
-
Publication number: 20140065067Abstract: Iodinated amphiphilic compound of formula (I): AG1-X—R??(I) wherein AG1 represents an unsaturated (C8-C52) aliphatic hydrocarbon chain found in fatty acids having specific location of double bonds, the chain including at least one iodine atom directly linked to a carbon atom of a non-conjugated double bond by a covalent link, the second carbon atom of the double bond bearing a halogen atom different from a iodine atom, X represents a polyethylene glycol including 1 to 50 ethylene glycol groups, R represents a hydrogen atom or a group AG2 being identical to or different from AG1, AG1, X, R and AG2 being selected so that the amphiphilic compound has a hydrophilic/lipohilic balance included between 4 and 30.Type: ApplicationFiled: December 13, 2011Publication date: March 6, 2014Applicant: UNIVERSITE DE STRASBOURGInventors: François Hallouard, Nicolas Anton, Guy Zuber, Thierry Vandamme, André Constantinesco, Philippe Choquet
-
Publication number: 20140065068Abstract: The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.Type: ApplicationFiled: March 11, 2013Publication date: March 6, 2014Applicant: ENDOCYTE, INC.Inventor: ENDOCYTE, INC.
-
Publication number: 20140065069Abstract: The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques. The conjugates of the invention distinguish between tropoelastin and elastin in plaques. The presence of tropoelastin can act as an indication that a plaque is liable to rupture or erode. Such information allows assessment of disease progression and response to treatment.Type: ApplicationFiled: February 8, 2012Publication date: March 6, 2014Applicant: KING'S COLLEGE LONDONInventors: Rene Botnar, Alkystis Phinikaridou
-
Publication number: 20140065070Abstract: The present application relates to methods of preparing radiohalogenated compounds, to compounds useful in such methods and to radiohalogenated compounds useful for imaging and/or therapy.Type: ApplicationFiled: August 28, 2013Publication date: March 6, 2014Applicant: MCMASTER UNIVERSITYInventors: John Valliant, Alla Darwish, Stephanie Rathmann, Afaf Genady
-
Publication number: 20140065071Abstract: The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations.Type: ApplicationFiled: October 28, 2013Publication date: March 6, 2014Inventors: Edmund C. METCALFE, Jo Anna MONTEFERRANTE, Margaret NEWBORN, Irene KUCHAREWICZ ROPIAK, Ernst SCHRAMM, Gregory W. WHITE, Julius P. ZODDA
-
Publication number: 20140065072Abstract: Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.Type: ApplicationFiled: November 11, 2013Publication date: March 6, 2014Applicant: ALT Solutions Inc.Inventor: Igor E. BONDAREV
-
Publication number: 20140065073Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.Type: ApplicationFiled: February 27, 2013Publication date: March 6, 2014Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventor: HUNTINGTON MEDICAL RESEARCH INSTITUTES
-
Publication number: 20140065074Abstract: A method of tracking growth and metastasis of specific cells in vivo is disclosed. The method of the disclosure includes culturing the specific cells in a medium containing 0.1 ?M to 10 mM nanoparticles as a biomarker for X-rays, such that the specific cells carry the nanoparticles, administering the specific cells carrying the nanoparticles to a subject, irradiating the subject by an X-ray source, and determining the growth and metastasis of the specific cells by X-ray images of the nanoparticles in the subject.Type: ApplicationFiled: August 31, 2013Publication date: March 6, 2014Applicant: ACADEMIA SINICAInventors: Yeu-Kuang Hwu, Chia-Chi Chien
-
Publication number: 20140065075Abstract: Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes an unchelated aminocarboxylate functional group; a metal ion bound to a metal-complexable portion; and a linker joining the targeting portion and the metal-complexable portion of the contrast agent. The portion that is not bound to a metal ion is for binding to necrotic tissue in the subject.Type: ApplicationFiled: April 17, 2012Publication date: March 6, 2014Applicant: RF THERAPEUTICS INC.Inventors: Jidong Zhang, Kenneth Curry
-
Publication number: 20140065076Abstract: Apparatus and methods are described herein for a container with a unit dose of a concentrated substance that can be diluted and orally consumed using the container. In some embodiments, an apparatus includes a container body that defines an opening in fluid communication with an interior of the container body. A cap is coupled to the container body and encloses the opening. A unit dose of a concentrated medicament or a concentrated contrast agent is disposed within the interior of the container body. The unit dose of concentrated medicament or contrast agent can be diluted to a select dilution strength with a volume of a liquid receivable through the opening and within the interior of the container body. In some embodiments, the apparatus can include a barrier member in which the container body and cap can be disposed to protect the medicament or contrast agent from light and/or moisture.Type: ApplicationFiled: August 30, 2012Publication date: March 6, 2014Applicant: OTSUKA PHARMACEUTICAL CO. LTD.Inventors: Scott Wayne Hollander, Joel Robert Timberlake, Marjory Kadash
-
Publication number: 20140065077Abstract: Apparatus and methods are described herein for a container with a unit dose of a concentrated substance that can be diluted and orally consumed using the container. In some embodiments, an apparatus includes a container body that defines an opening in fluid communication with an interior of the container body. A cap is coupled to the container body and encloses the opening. A unit dose of a concentrated medicament or a concentrated contrast agent is disposed within the interior of the container body. The unit dose of concentrated medicament or contrast agent can be diluted to a select dilution strength with a volume of a liquid receivable through the opening and within the interior of the container body. In some embodiments, the apparatus can include a barrier member in which the container body and cap can be disposed to protect the medicament or contrast agent from light and/or moisture.Type: ApplicationFiled: July 3, 2013Publication date: March 6, 2014Inventors: Scott Wayne Hollander, Joel Robert Timberlake, Marjory Kadash
-
ORAL CARE COMPOSITION FOR PROMOTING AND MAINTAINING ORAL HEALTH AND METHOD OF FORMING AND USING SAME
Publication number: 20140065078Abstract: An oral care composition, a method of forming the oral care composition, and a method of using the oral care composition are disclosed. The oral care composition includes a plurality of enzymes to prevent formation of and/or facilitate the breakup of biofilm in an oral cavity and a metal ion management system to inhibit growth of gram negative bacteria.Type: ApplicationFiled: September 3, 2013Publication date: March 6, 2014Applicant: Dr. Fresh, LLCInventor: Puneet Nanda -
Publication number: 20140065079Abstract: A method for producing de-colored shellac by dissolving colored shellac in an aqueous solution comprising an alkaline agent; contacting the colored shellac in the aqueous solution with a sufficient amount of a chlorite salt to achieve de-coloration of the shellac; precipitating the de-colored shellac by neutralizing the aqueous solution with an acid; and recovering the precipitated de-colored shellac from said aqueous solution. The de-colored shellac produced is non-toxic and suitable for human use. Dental compositions comprising the de-colored shellac are disclosed, as well as uses of the de-colored shellac as a food product coating, a nail polish or varnish, and a wood varnish.Type: ApplicationFiled: July 15, 2013Publication date: March 6, 2014Inventors: Thi Cong To, Thuc Soan Nguyen