Abstract: A multiparticulate formulation includes a plurality of individual spheroidal enteric coated cores containing L-menthol from an at least 80% pure L-menthol source. A subcoat is beneath the enteric coat. The enteric coated cores have a diameter of not more than 3 mm. The multiparticulate formulation may be used to treat gastrointestinal disorders, such as irritable bowel syndrome.

Abstract: A montelukast composition having a therapeutically effective amount of montelukast in a sustained release is disclosed. A montelukast composition having a therapeutically effective amount of montelukast in an immediate release and sustained release is also disclosed.

Abstract: An enteric-coated oral dosage form comprising an acid labile active pharmaceutical ingredient where the composition is substantially free of monomeric phthalic acid esters and synthetic oils is described herein. Also provided are methods for making and using the enteric-coated oral dosage form. The disclosed pharmaceutical compositions comprise an enteric coating which includes at least one plasticizer, at least one film-forming agent and optionally at least one anti-sticking agent.

Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.

Abstract: The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture.

Abstract: Disclosed are a pharmaceutical composition for a sexual function improvement, an erection dysfunction therapy agent containing the urechis unicinctus as an effective component, a health function food for a sexual function improvement and a method for preparing an urechis unicinctus extract with a sexual function improvement activation each of which contains an urechis unicinctus extract which is added as an effective component and yielded by way of a process at a temperature 100˜130° C. at a pressure of 1 Kgf/cm2 for 20˜40 minutes and then with an ultrasonic wave at a frequency 35˜45 KHz for 50˜70 minutes.

Abstract: The invention discloses a new solvent-free process for obtaining phospholipids and neutral lipids enriched krill oils containing DHA and EPA poly-unsaturated fatty acids and astaxanthin. The process includes cooking fresh krill at high temperature—without agitation and or grinding; decanting the cooked krill for obtaining a partial de-fatted and de-watered solid and a liquid; squeezing the obtained solid to obtain a press liquid and a solid fraction; centrifuging the press liquid to obtain the phospholipids enriched krill oil; centrifuging of the decanter liquid obtained to obtain the neutral lipid enriched krill oil and stickwater.

Abstract: The claimed product relates to the food industry, and specifically to biologically active food additives (BAA) for the prophylaxis of erectile dysfunction in men, produced on the basis of natural components. The essence of the claimed product consists in that a biologically active food additive for the prophylaxis of erectile dysfunction in men. The claimed additive includes L-arginine and drone brood, with the following ratio of ingredients: 50-96.2% by mass of L-arginine and 3.8-50% by mass of drone brood.

Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-tem durability and function.

Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.

Abstract: The invention provides compositions comprising mesenchymal stem cell (MSC) derived exosomes, and methods of their use in subjects having certain lung diseases including inflammatory lung disease.

Abstract: A method for treating or preventing a disease, condition or state in a subject in need thereof by administering to the subject an effective amount of the (?)-enantiomer of perhexyline or a pharmaceutically acceptable salt, prodrug or derivative thereof, substantially free of the (+)-enantiomer, or pharmaceutical composition containing same. The disease, condition or state may be associated with altered tissue energetics, impaired tissue energetics, altered cardiac tissue energetics, impaired cardiac tissue energetics, altered hepatic tissue energetics, impaired hepatic tissue energetics, and diabetes.

Abstract: A chewing gum including at least one biodegradable polymer, wherein the molecular weight of the polymer is at least 105,000 g/mol (Mn). According to the invention, it has moreover been realized that various problems associated with the prior art may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

Abstract: This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.

Abstract: A spray composition and method are provided that are effective for reduction or elimination of the psychological hunger for foods for which a patient wishes to reduce consumption, Such ingredients preferably include but are not limited to cayenne pepper, alcohol, salt, citric acid and a sweetener such as saccharin plus ingredients that desensitize the taste buds and reduce hunger, including thymol, camphor benzoin and spearmint. The composition of the invention is preferably sprayed into the mouth, resulting in a lessening or elimination of psychological hunger.

Abstract: A novel dietary supplement and methods for manufacturing the said dietary supplement are disclosed for promoting healthy cartilages, connective tissues and bones. The dietary supplement of the present invention comprises glucosamine hydrochloride, collagen, and other dietary ingredients. Some ingredients of the dietary supplement of the present invention help to maintain the functions of cartilages, connective tissues and bones. Some ingredients of the dietary supplement of the present invention also exhibit anti-inflammatory properties. Overall, these ingredients of the dietary supplement are beneficial to the health of human and other animals.

Abstract: Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce Apoptosis selectively in tumor/cancer cells while sparing normal cells. These methods are based upon employing drugs that, acting in synergistic combinations, trigger selective killing of malignant cells. Since the invention is based upon fundamental cell cycle requirements, to the extent that calcium handling abnormalities are a general characteristic of the malignant state, the methods presented here are widely applicable regardless of tissue of origin and degree of cellular de-differentiation.

Abstract: Provided is a method for protecting an individual against radiation-induced internal damage that comprises administering an effective amount of an oral composition. The oral composition comprises a mixture of Gynostemma pentaphyllum, Crataegus pinnatifida (hawthorn), and Camellia sinensis (green tea) to an individual so that radiation-induced internal damage will be prevented or ameliorated.

Abstract: The present disclosure provides electrodes that possess hydrogels for contacting skin. In embodiments, an electrode of the present disclosure may include a substrate and a conductive composition on at least a portion of a surface of the substrate, the conductive composition including at least one hydrogel and at least one component capable of providing either a cooling or warming sensation upon electrical stimulation. Methods for forming these hydrogels and electrodes are also provided.

Abstract: The invention relates to a novel technique for germinating a sproutable food such as rice, other types of cereals, or seeds. Provided is a novel germination technique capable of increasing a content of glutamate, accelerating an enrichment of gamma-aminobutyric acid, and exerting excellent functionality for the body, and a novel functional food material or pharmaceutical agent. A sprouted cereal is produced by soaking the cereal in a soaking solution prepared by addition of at least one carbonate selected from alkali metal carbonate, and alkaline earth metal carbonate to water to make the cereal absorb the soaking solution, followed by allowing the cereal to germinate under predetermined conditions.

Abstract: Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.

Abstract: An anti-inflammatory composition for inhibiting the secretion of cytokines, with the composition being based on a decoction of papaya leaves, a method of obtaining such a composition and a method of manufacturing an anti-inflammatory remedy for inhibiting cytokine secretion, having the composition the anti-inflammatory composition as its active principle. The method of obtaining the composition includes the steps of producing a decoction from papaya leaves, filtering the decoction in order to obtain a filtrate and atomizing the filtrate.

Abstract: An impression system is provided for capturing an anatomical impression of an animal. The impression system comprises a foam that substantially retains an impression after application of pressure and subsequent removal of pressure and a case having a recessed area for receiving the foam and a case for retaining the foam therein. The system further comprises a cover having a viewing pane attachable to the case for providing viewing of the foam when closed.

Abstract: A solid face die plate for an underwater pelletizer includes a carrier or holding plate having a circular slot for holding a hard anti-wear element of highly wear-resistant material through which the extrusion orifices open for extruding polymer. The solid face die plate eliminates the need for insulation or plugging material in the center of the die plate and, by embedding the hard anti-wear element within the carrier, protects the edges of the hard anti-wear element for longer wear life.

Abstract: An apparatus for uniformly curing resin is described herein. The apparatus includes at least a lamp system that is to emit ultraviolet (“UV”) light. The lamp system is to emit the UV light from a light-emitting diode (“LED”) light source, which is to be energized and controlled by an electrical circuit. The electrical circuit may be provided as part of a circuit board which has power delivered thereto from a power cord. The lamp system can further include a handle having an attachment device so that the lamp system may be securely engaged with a glass surface. The lamp system may be adapted to be coupled with a resin injection system. When engaged with the resin injection system, the lamp system can deliver UV light to the injected resin so that the injected resin may be quickly and uniformly cured.

Abstract: A guide device 3 for smoothing into a shape of a flat plate a parison P having a semi-circular shape in a planar cross-section, the parison being extruded from an extrusion device 1 and divided into two by a cutter 2, wherein the guide device includes a spiral guide element 4 that is in contact with the parison P while rotating about an axis, the spiral guide element being formed so as to rotate in opposite directions with each other on the left and right of a middle part 4C as a boundary so as to expand the parison P to the left and right. The spiral guide element 4 is formed in a protruding shape on an outer periphery of a shaft 5 rotated by the driving of a drive motor M.

Abstract: Method and apparatus for cooling a heated mould (12, 14, 16) of a device (10) for blow-moulding thermoplastic containers, the device including: a mould (12, 14, 16) having an internal face which delimits a moulding cavity (18) and which includes an external face (20, 28) which surrounds the moulding cavity (18); heating elements for heating the mould to a determined temperature and which are deactivated when the cooling method is implemented; characterized in that the mould (12, 14, 16) is cooled by circulating heat-transfer fluid directly in contact with the external face (20, 28) thereof.

Abstract: An injection molding apparatus includes a heating device heating reinforcing fiber assemblies, an injection cylinder to which a thermoplastic resin and the reinforcing fiber assemblies are supplied, a first screw compressing and kneading the thermoplastic resin, a second screw fibrillating the reinforcing fiber assemblies and dispersing reinforcing fibers obtained by the fibrillation into the thermoplastic resin, a resin supply portion supplying the thermoplastic resin to a void formed between the injection cylinder and the first screw, and a reinforcing fiber supply portion supplying the reinforcing fiber assemblies to a void formed between the injection cylinder and the second screw. The second screw serves as one of a non-compression screw and a low compression screw including a low compression ratio by which the reinforcing fibers are inhibited from being excessively broken at a time of receiving a shearing force generated by a rotation of the second screw.

Abstract: A closing unit of an injection molding machine includes a moveable mold mounting plate and a fixed mold mounting plate, a hydraulic pressure mechanism for building up a closing pressure, at least one column provided with an external profile, and at least one two-part nut which is provided with an internal profile and the halves of which are coupled in motionally opposite relationship. The at least one column in the closed condition of the two-part nut is lockable by a positively locking relationship between the internal profile and the external profile relative to the moveable mold mounting plate or relative to the pressure mechanism. There is also provided an electric drive for opening and closing the two-part nut.

Abstract: Nutritional compositions with targeted sodium levels for young children (e.g., ages 1-4 years) are provided. In a general embodiment, the present disclosure provides nutritional compositions having a targeted level of sodium, made from wholesome foods that provide macronutrients and micronutrients needed in a child's daily diet and are developmentally appropriate for this age group. The sodium levels of the nutritional compositions may be less than or equal to about 200 mg per 100 g nutritional composition. Methods of making nutritional compositions with targeted sodium levels while also achieving acceptable product flavors at both pilot and factory levels are also provided. The batching methods may include adding a slurry of ice, cold water and KCl to a batched product after an initial cooling step and before packaging.

Abstract: A feed additive composition includes a protective agent, lecithin, an acidic or neutral amino acid, and water. A method of producing a feed additive composition includes preparing a molten mixture of a protective agent, lecithin, and an acidic or neutral amino acid, and immersing the molten mixture in water or an aqueous liquid to obtain a solidified mixture. Feed additives may be obtained by such method. The protective agent may include a hydrogenated vegetable oil or hydrogenated animal oil having a melting point of higher than 50° C. and lower than 90° C.

Abstract: Provided is a process of forming a vanilla extract wherein green ripe vanilla beans are exposed to a high drying temperature, extracted with a solvent, and treated with beta-glucosidase enzyme to convert glucovanillin to vanillin enzymatically, thereby providing a vanilla extract with a good vanillin yield and complex well-balanced vanilla aroma lacking undesirable off-notes.

Abstract: The present invention is directed to a method for preparing flour dough with reduced content of gluten starting from gluten containing cereals flours. In particular, the invention is directed to the use of lactic acid bacteria and fungal enzymes for the partial degradation of gluten in wheat flour in order to obtain flour dough with residual gluten concentration from 20,000-80,000 ppm. The flour dough obtained by the method of the invention can be used to prepare food products with reduced gluten content.

Abstract: The present invention relates to a method of myceliation of agricultural substrates for producing functional foods with health benefits, wherein the method comprises of inoculating an agricultural substrate with one or more species of pure fungal culture comprising Basidiomycota and Ascomycota derived from liquid state fermentation, enabling mycelial growth on the agricultural substrate by controlling growth conditions and harvesting of a myceliated agricultural product after the mycelial growth reaches a desired stage. The present invention further provides a myceliated agricultural product enriched with nutrients, processed into a nutraceutical or functional food for human consumption.

Abstract: A nutritional composition is provided herein for optimizing fats, carbohydrates, and protein caloric ratios as it relates to balanced nutrition, general health, and muscle performance during exercise and for enhancing muscle cell repair and recovery following the cessation of exercise, comprising: a) about 18% to about 23% by weight, e.g. about 19% to about 21%, of whey protein, e.g. whey protein isolate; b) about 65% to about 70% by weight, e.g. about 67% to about 69%, of a “Superfruit and Vegetable Blend”, a concentrated fruit juice and a sweetener, such as honey; and c) about 10% to about 15% by weight, such as about 11% to about 13%, of a vegetable oil, e.g., olive oil, such as extra virgin olive oil, virgin olive oil, cold pressed olive oil.

Abstract: An improved package for heating dry food products is provided. The present invention allows a dry food product to be heated in a microwave oven. The package has barrier properties and at least a portion of an outer surface that is water absorbent, so that the food package may be wetted prior to being heated in the microwave in order to prevent burning of the food products inside.

Abstract: A system and a method for the production and provision of CO2 gas is disclosed. A sealable chamber is equipped with heating means and when sodium bicarbonate is placed in it and heated to its decomposition temperature CO2 gas is released. The released gas is conveyed into liquid within a container and when the pressure of the gas in the container raises more and more CO2 gas is dissolved. The heating may he done by conduction mechanism or by induction mechanism. The sodium bicarbonate or any other material including carbon dioxide may be disposed in powder or solid form. I may be disposed in thin envelope case.

Abstract: A mold for forming a frozen pop or molded treat, and a method for forming a frozen pop and frozen pops or molded treats made therefrom are described which include a female mold body defining an interior mold space and having a first open end and a second end; a base having a support surface with an opening extending longitudinally therethrough, the base configured to be positioned around or within the first end of the female mold body and to support by the support surface a frozen pop or molded treat formed in the interior space of the female mold body; and a removable male insert mold body, wherein the male insert mold body is configured to fit through the opening in the support surface in the base.

Abstract: Packaging and methods of making and using the same are disclosed.

Abstract: The invention relates to a capsule associated with the perforating device of a machine used to prepare drinks by injecting water into the capsule. The capsule includes a side wall and a base forming a self-supporting shell, an upper wall enclosing a sealed volume inside the shell that contains a substance to be extracted, and a filter membrane in the sealed volume disposed on the base. The base has a peripheral portion and a central portion, the central portion extending beneath the peripheral portion with a depth and having a low wall portion configured to be perforated or cut by the perforating device in order to create one or more outlets for the drink flowing through the filter membrane. The peripheral portion comprises flow channels extending radially from the low wall portion to the side wall and being disposed between the support spokes to support the filter membrane.

Abstract: The present invention relates to a bakery product with improved flavour properties and in particular an improved flavour shelf life. The product is prepared from a dough comprising flour, water, proline and an alkane polyol preferably wet, present in an effective amount to improve the flavour properties of said product when baked.

Abstract: Oxygen sensors and their uses are disclosed, and more particularly to oxygen sensors for use in product packaging for storing an article in a packaging envelope under modified atmosphere conditions wherein the oxygen sensors comprise solid oxo-hydroxy metal ion materials, optionally modified with one or more ligands and/or optionally having polymeric structures. The sensors may be present in a hydrated, oxygen permeable matrix, for example formed from a material, such as gelatine. The sensors are useful in many technical fields, and find particular application in the field of food packaging as they are safely disposable (e.g. are environmentally friendly), cheap to manufacture, and provide detectable changes in the presence of oxygen that are easy to read.

Abstract: A nozzle panel for holding bakery accessories comprising a flat panel base, a plurality of panel protrusions integral with the panel base and at least one bakery accessory attachable to the panel protrusions on the panel base. The panel protrusion includes a lip engagable with a bakery nozzle. The panel protrusion lip may be an interrupted helical thread attached to the panel protrusion, at least one nozzle engagable with the panel protrusion by twisting the nozzle relative to the panel base less than 360° . The nozzle may include an inwardly extending interrupted helical thread adjacent a bottom edge of the nozzle and may be rotatably engagable with the interrupted thread of panel protrusion. The nozzle panel may include at least one container attachable to the panel protrusion. The container may be cylindrical and include an opening at one end and a removable lid engagable with the opening.

Abstract: A bakery tray made of an all-natural fibrous material is disclosed to store, ship, bake, and display single-serve baked goods such as muffins and cupcakes. The tray has a plurality of cups and a top plate for serving the cups in position relative to each other. The tray also includes various structures to provide uniform baking of baked goods in either a convention or microwave oven.

Abstract: Disclosed are methods for producing and maintaining a very low level of oxygen in a sealed container for maintaining a foodstuff. In one aspect, the method comprises (1) a first oxygen reduction step wherein the oxygen content in said container is reduced to no more than 20,000 ppm; (2) maintaining the foodstuff in the container such that the oxygen content in the foodstuff and the gaseous environment approaches equilibrium; and (3) a second oxygen reduction step wherein the oxygen content in said container is reduced to no more than 2000 ppm. Systems useful in the methods disclosed herein.

Abstract: A system for automatically forming chunks and spears at high speed from unpeeled fruit items is provided. The fruit is sliced into unpeeled wedges. The unpeeled wedges are conveyed into a plurality of staggered transverse chunking blades, wherein the flesh, but not the peel, is cut sequentially from the center of each wedge outwardly, flattening each wedge. A peel removal knife is located to sever the peel of each wedge from the center outwardly after the transverse chunk cutting blades have cut the flesh. Spears may be formed by deleting some of the transverse chunking blades.

Abstract: A muddler aid device is provided for muddling ingredients in an open-ended receptacle. The muddler aid device includes a body in the form of a generally planar disc to cover at least a majority of a mouth of the open-ended receptacle and a sidewall that extends from a periphery of the body to surround at least a substantial portion of a perimeter of the mouth of the open-ended receptacle. The device further includes a muddler access port positioned at or near the periphery of the body which is sized to receive a muddler therethrough. A plurality of discharge apertures are arranged proximate the periphery of the body to strain contents of the open-ended receptacle after muddling thereof. A grip feature may also be formed in the body to assist in discharging strained contents from the open-ended receptacle. Related methods of muddling contents are also provided.

Abstract: The invention features a press for making a football shaped pressed food that may include, e.g., a logo, insitodgnia, and/or indicium of a football, e.g., the laces, pebble-grain texture, and/or vertical stripes) imprinted therein or thereon, and methods and uses thereof.

Abstract: A baking device for baking and cooling baked goods includes a rectangular baking pan formed from a single sheet of metal with planar opposing baking and bottom pan surfaces, including indentations positioned at four corners to extend out as protrusions from the bottom pan surface as standoffs. The baking device also includes a complementary rectangular cooling rack formed from a single sheet of metal with planar opposing baking and bottom rack surfaces, including indentations or depressions formed in the baking rack surface and positioned at four corners to extend out as protrusions from the bottom cooling rack surface and a plurality of small gauge holes. Dimensions of the cooling rack and baking pan are ensure that the cooling rack seats snugly in the baking pan so that the bottom cooling rack surface contacts and presses against the baking pan surface in an assembled state.

Abstract: A healthy Omega-7 based cooking oil for frying and cooking foods raw or prepared foods. The healthy cooking oil comprises mixture of oils having at least 30%-60% Omega-7, and 70%-30% any healthy or neutral oil. The Omega-7 oil is purified from sea buckhorn and/or its derivatives, algae and/or its derivatives, fish oil and/or its derivatives, and/or macadamia nuts and/or its derivatives. Healthy or neutral oils may be canola oil and walnut oil. The Omega-7 cooking oil may further comprises stabilizers, antioxidants, and polyphenols in an amount not to exceed about 10% or the oil mixture.