Patents Issued in July 31, 2014
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Publication number: 20140213426Abstract: A seal composition includes a first alkaline earth metal oxide, a second alkaline earth metal oxide which is different from the first alkaline earth metal oxide, aluminum oxide, and silica in an amount such that molar percent of silica in the composition is at least five molar percent greater than two times a combined molar percent of the first alkaline earth metal oxide and the second alkaline earth metal oxide. The composition is substantially free of boron oxide and phosphorus oxide. The seal composition forms a glass ceramic seal which includes silica containing glass cores located in a crystalline matrix comprising barium aluminosilicate, and calcium aluminosilicate crystals located in the glass cores.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: BLOOM ENERGY CORPORATIONInventors: Ananda H. Kumar, Dien Nguyen, Martin Janousek, Tad Armstrong
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Publication number: 20140213427Abstract: The present disclosure relates to a method and composition for forming photocatalytic capped colloidal nanocrystals which may include semiconductor nanocrystals and inorganic capping agents as photocatalysts. Photocatalytic capped colloidal nanocrystals may be deposited on a substrate and treated to form a photoactive material which may be employed in a plurality of photocatalytic energy conversion applications such as the photocatalytic reduction of carbon dioxide. Different semiconductor materials, shapes and sizes may be combined when forming photocatalytic capped colloidal nanocrystals, allowing band gaps to be tuned and expand the range of wavelengths of sunlight usable by the photoactive material.Type: ApplicationFiled: January 31, 2013Publication date: July 31, 2014Applicant: Sunpower Technologies LLCInventor: Sunpower Technologies LLC
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Publication number: 20140213428Abstract: One exemplary embodiment can be a process for stripping. The process can include passing catalyst to a stripping vessel containing a riser, providing a plurality of baffles having a first baffle and a second baffle, and providing one or more packing layers. The stripping vessel and riser may define an annular zone including annular area for stripping of the catalyst, and the first and second baffles collectively overlap in no more than about 50% of the annular area. Often, the first baffle is coupled to an outer circumference of the riser and extends outward, and the second baffle is coupled to an inner circumference of the stripping vessel and extends inward. Typically, the one or more packing layers are within the annular zone.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: UOP LLCInventors: Brian W. Hedrick, Paolo Palmas
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Publication number: 20140213429Abstract: In a NOx removal catalyst used for removing nitrogen oxides in flue gas, when a silica (Si) component as an inhibitor that causes an increase in a SO2 oxidation rate accumulates on a surface of the catalyst, the silica component accumulating on the surface of the catalyst is dissolved, thereby regenerating the catalyst. Accordingly, the inhibitor such as the silica component covering the surface of the NOx removal catalyst can be removed, thereby enabling to provide a catalyst without having an increase in the SO2 oxidation rate of the regenerated NOx removal catalyst.Type: ApplicationFiled: September 5, 2012Publication date: July 31, 2014Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.Inventors: Katsumi Nochi, Masashi Kiyosawa
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Publication number: 20140213430Abstract: Two or more acidic gaseous species such as hydrogen sulphide and carbon dioxide from an adsorbent can be selectively removed from a Fig. la feed gas by contacting the feed gas with an adsorbent for these acidic species, followed by: a. subjecting the adsorbent to a first purging gas, said first purging gas not containing said first acidic gaseous species and containing said second acidic gaseous species at a partial pressure which is at least the partial pressure of said second gaseous species in said feed gas; b. subsequently subjecting the adsorbent to a second purging gas, said second purging gas not containing said first gaseous species and, containing this second gaseous species at a partial pressure which is lower than the partial pressure of said second gaseous species in said feed gas.Type: ApplicationFiled: August 3, 2012Publication date: July 31, 2014Applicant: Stichting Energieonderzoek CentrumInventors: Paul Dean Cobden, Hendricus Adrianus Johannes Van Dijk, Stephane Walspurger
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Publication number: 20140213431Abstract: Disclosed are a molecular sieve catalyst and a preparation method thereof to produce light olefins from cracking naphtha catalytically in severe environments of high temperature and high moisture. In detail, the catalyst is prepared by spray-drying and calcining the mixed slurry, in which 0.01˜5.0 wt % of MnO2 and 1˜15 wt % of P2O5 are simultaneously imbedded in catalyst which consists of zeolite, clay and inorganic complex. According to the present invention, the method that manganese and phosphate are imbedded simultaneously in zeolite and inorganic complex is used to increases thermal-stability of obtained spherical catalyst, and increase olefin yield of cracking hydrocarbon such as naphtha by protecting acid-site of zeolite. To synthesize the required catalyst, the important procedures are mixing ratio and mixing sequence of Mn, P, zeolite, and inorganic complex.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, SK INNOVATION CO., LTDInventors: DAE HYUN CHOO, HONG CHAN KIM, SUK JOON KIM, JI MIN KIM, TAE JIN KIM, SUN CHOI, SEUNG HOON OH, YONG SEUNG KIM, DEUK SOO PARK, YONG KI PARK, CHUL WEE LEE, HEE YOUNG KIM, WON CHOON CHOI, NA YOUNG KANG, BU SUB SONG
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Publication number: 20140213432Abstract: Methods for enhancing the mesoporosity of a zeolite-containing material. Such methods may comprise contacting a composite shaped article containing at least one zeolite and at least one non-zeolitic material with at least one pH controlling agent and at least one surfactant. Such methods may be performed under conditions sufficient to increase the pore volume of at least one 10 angstrom subset of mesoporosity.Type: ApplicationFiled: March 29, 2014Publication date: July 31, 2014Applicant: Rive Technology, Inc.Inventors: Javier Garcia Martinez, Lawrence B. Dight, Barry K. Speronello
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Publication number: 20140213433Abstract: A bis-imine pyridine complex of lanthanides having general formula (I): Said bis-imine pyridine complex of lanthanides having general formula (I) can be advantageously used in a catalytic system for the (co)polymerization of conjugated dienes.Type: ApplicationFiled: September 13, 2012Publication date: July 31, 2014Inventors: Giovanni Ricci, Anna Sommazzi, Giuseppe Leone, Aldo Boglia, Francesco Masi, Maria Caldararo
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Publication number: 20140213434Abstract: Provided is a resin-supported catalyst including a cured body of a thermosetting resin and fine particles having catalytic activity supported onto the surface of the cured body, in which the thermosetting resin has a phenolic hydroxyl group.Type: ApplicationFiled: August 28, 2012Publication date: July 31, 2014Applicants: KOCHI UNIVERSITY OF TECHNOLOGY, SUMITOMO BAKELITE CO., LTD.Inventors: Masahiko Funabashi, Toru Kamata, Nagatoshi Nishiwaki
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Publication number: 20140213435Abstract: Quaternary phosphonium haloaluminate compounds according to Formula (I): wherein R1-R3 are the same alkyl group; R4 is different than R1-R3 and is chosen from a C4-C12 alkyl; and X is a halogen, are provided herein for use as an ionic liquid catalyst for reacting olefins and isoparaffins to generate an alkylate.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: CYTEC INDUSTRIES INC.Inventors: Susie C. Martins, Douglas A. Nafis, Alakananda Bhattacharyya
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Publication number: 20140213436Abstract: The present invention concerns bleaching of substrates with an aqueous solution of a water soluble salt of a preformed transition metal catalyst together with hydrogen peroxide.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: CONOPCO INC., D/B/A UNILVERInventors: RONALD HAGE, JEAN HYPOLITES KOEK, MARINUS MARIA CORNELIS GERARDUS WARMOESKERKEN
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Publication number: 20140213437Abstract: Powder catalysts that comprise particles of chemical compounds of Au and Cu deposited on acid-washed carbon-based supports are effective catalysts in ethyne hydrochlorination to produce vinyl chloride monomers (VCMs). They give a high selectivity and productivity of VCM and decreased amounts of the byproducts of chloroethane, dichloroethane and others. Thiocyanates are used as complexing agents to extend the catalyst lifetime. The activity of the catalyst is enhanced by doping nitrogen atoms into the support.Type: ApplicationFiled: January 30, 2013Publication date: July 31, 2014Applicant: Tsinghua UniversityInventors: Guohua Luo, Kai Zhou, Wei Wang, Fei Wei
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Publication number: 20140213438Abstract: The present invention relates to a high activity olefin polymerization catalyst comprising a boron-containing silica support and the preparation thereof. This invention is characterized in that the support is heat treated in combination with a chemical treatment using a boron compound. The boron compound used in the chemical treatment of this invention is boron halide, preferably boron trichloride. The catalyst of this invention has the weight of boron comparing with the support is 0.5 to 0.7% and has the weight of the boron relative to the catalyst of 0.1 to 0.5%. The catalyst of this invention has chemical compositions comprising:—Boron 0.1-0.5% wt;—Titanium 4-6% wt;—Magnesium 2-6% wt;—Chloride 15-25% wt.Type: ApplicationFiled: September 5, 2012Publication date: July 31, 2014Applicant: PTT Global Chemical Public Company LimitedInventors: Sutheerawat Samingprai, Onteera Yenjitrattanawalee, Chaya Chandavasu
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Publication number: 20140213439Abstract: A catalyst for exhaust gas purification having superior exhaust gas purification performance is provided. Disclosed is a catalyst containing, as a catalyst support, a composite phosphate containing yttrium and phosphorus and having a composition ratio of yttrium to phosphorus (Y/P) of greater than 1 as a molar ratio.Type: ApplicationFiled: April 24, 2012Publication date: July 31, 2014Applicant: MITSUI MINING & SMELTING CO., LTD.Inventors: Michitaka Yamaguchi, Akiko Sugioka, Takahito Asanuma, Yunosuke Nakahara, Takahiro Sato
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Publication number: 20140213440Abstract: The instant disclosure relates to a preparation method of ethanol reforming catalyst, comprising the following steps. The first step is mixing a first metal precursor, a second metal precursor, and a third metal precursor with an organic medium to form a mixture. The next step is adding a surfactant to the mixture, and then allowing resting for 3 to 7 days to form a colloidal gel. The next step is calcining the colloidal gel for 1 to 5 hours in a first temperature region of 350° C. to 550° C., and then calcining the colloidal gel for 1 to 5 hours in a second temperature region of 800° C. to 1000° C. to form an ethanol reforming catalyst. The instant disclosure further provides an ethanol reforming catalyst composition.Type: ApplicationFiled: April 29, 2013Publication date: July 31, 2014Applicant: NATIONAL CHIAO TUNG UNIVERSITYInventors: CHI-SHEN LEE, SHENG-FENG WENG, YUN-SHENG CHEN, YUN-HSIN WANG
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Publication number: 20140213441Abstract: The present invention provides an electrocatalytic material and a method for making an electrocatalytic material. There is also provided an electrocatalytic material comprising amorphous metal or mixed metal oxides. There is also provided methods of forming an electrocatalyst, comprising an amorphous metal oxide film.Type: ApplicationFiled: September 4, 2012Publication date: July 31, 2014Inventors: Simon Trudel, Curtis Berlinguette
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Publication number: 20140213442Abstract: A children's coloring pad may incorporate thermochromic pigments that are specially formulated to develop color and clear color by respective applications of cold and hot temperatures. The pad may be used in a similar manner as with respect to finger painting, but without the residual mess.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: CHROMATIC TECHNOLOGIES, INC.Inventors: Terrill Scott Clayton, Timothy J. Owen
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Publication number: 20140213443Abstract: An erasing apparatus according to an embodiment includes an erasing section configured to erase an image formed on a sheet by heating the sheet that is transported through the erasing section, the erasing section including a heating roller, a press roller in contact with the heating roller. A motor rotates the heating and press rollers. A transportation section transports the sheet. The erasing apparatus further includes a controller that controls the erasing section and the transportation section so that a transportation speed of the sheet transported through the erasing section is a first transportation speed lower than a normal speed if a predetermined period of time from a start of a job has not elapsed.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Applicants: Toshiba Tec Kabushiki Kaisha, Kabushiki Kaisha ToshibaInventor: KEN IGUCHI
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Publication number: 20140213444Abstract: An erasing apparatus includes a conveyance path configured to convey a sheet on which an image is formed with a coloring agent which is erased by heating. A first erasing unit is disposed on the conveyance path and is configured to heat the sheet when the sheet is conveyed between a first heating component and a first press component. A second erasing unit is disposed on the conveyance path downstream from the first erasing unit and is configured to heat the sheet when the sheet is conveyed between a second heating component and a second press component. A control section is configured to control a temperature of the first heating component at a first temperature at which the image on the sheet can be erased and to control a temperature of the second heating component at a second temperature lower than the first temperature.Type: ApplicationFiled: January 31, 2014Publication date: July 31, 2014Applicants: Toshiba Tec Kabushiki Kaisha, Kabushiki Kaisha ToshibaInventor: Setsuo TAKADA
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Publication number: 20140213445Abstract: The present invention relates to agricultural methods and the use of 3-arylquinazolin-4-one derivatives of formula (I) wherein R1, R2, R3, R4, k and n are defined in the description in soil application methods. The compounds of the formula (I) are highly suitable for controlling animal pests such as insects and/or spider mites and/or nematodes by treating the soil/growth substrate by drenching or drip application or dipping or soil injection.Type: ApplicationFiled: August 31, 2012Publication date: July 31, 2014Applicant: BASF SEInventors: Florian Kaiser, Steffen Gross, Arun Narine, Koshi Gunjima
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Publication number: 20140213446Abstract: Herbicidal compositions and methods using a combination of (a) a compound of formula (I): or an agriculturally acceptable salt or ester thereof and (b) an aryloxyphenoxy propionate ACCase inhibitor herbicide selected from the group consisting of fluazifop-P, haloxyfop-P, and quizalofop-P or an agriculturally acceptable salt or ester thereof provide control of undesirable vegetation in, e.g., rice, wheat, barley, triticale, oats, rye, sorghum, corn or maize, oilseed rape, vegetables, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, industrial vegetation management (IVM) or rights-of-way.Type: ApplicationFiled: January 24, 2014Publication date: July 31, 2014Applicant: DOW AGROSCIENCES LLCInventors: Carla N. Yerkes, Norbert M. Satchivi, Bryston L. Bangel
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Publication number: 20140213447Abstract: Herbicidal compositions and methods using a combination of (a) a compound of formula (I): or an agriculturally acceptable salt or ester thereof and (b) diclosulam or clorasulam-methyl or an agriculturally acceptable salt thereof provide control of undesirable vegetation in, e.g., rice, wheat, barley, oats, rye, sorghum, corn or maize, oilseed rape, vegetables, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, industrial vegetation management or rights-of-way.Type: ApplicationFiled: January 24, 2014Publication date: July 31, 2014Applicant: DOW AGROSCIENCES LLCInventors: Bryston L. Bangel, Norbert M. Satchivi
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Publication number: 20140213448Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: DOW AGROSCIENCES LLCInventors: Ann M. Buysse, Noormohamed M. Niyaz, David A. Demeter, Yu Zhang, Martin J. Walsh, Asako Kubota, Ricky Hunter, Tony K. Trullinger, Christian T. Lowe, Daniel Knueppel, Akshay Patny, Negar Garizi, Paul R. LePlae, JR., Frank Wessels, Ronald Ross, JR., Carl DeAmicis, Peter Borromeo
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Publication number: 20140213449Abstract: The present invention is directed to the discovery, isolation, identification and methods of synthesis of a novel chemical complex that can be used to stabilize mixtures of different chemical compounds, and in particular mixtures of different herbicidal compounds.Type: ApplicationFiled: December 13, 2013Publication date: July 31, 2014Applicant: BAYER CROPSCIENCE LPInventors: Tai-Teh WU, Karen L. EAGLES, Michael W. EDENFIELD
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Publication number: 20140213450Abstract: The present invention relates, inter alia, to a novel herbicide formulation comprising: (a) an aqueous phase; (b) an HPPD inhibitor in suspension in the aqueous phase; (c) an encapsulated chloroacetamide or an isoxazoline herbicide in suspension in the aqueous phase; (d) glyphosate and/or glufosinate or an agrochemically acceptable salt thereof, in solution in the aqueous phase. The invention further relates to a process for the preparation of an herbicide formulation of the invention and to a process for the control of unwanted vegetation.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: SYNGENTA CROP PROTECTION LLCInventor: Alan Frederick Nelson
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Publication number: 20140213451Abstract: The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) even at very high concentration (470-600 g a.e./l).Type: ApplicationFiled: April 1, 2014Publication date: July 31, 2014Applicant: Monsanto Technology LLCInventors: Shawn Zhu, William Abraham, John Hemminghaus
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Publication number: 20140213452Abstract: Herbicidal compositions and methods using a combination of (a) a compound of formula (I): or an agriculturally acceptable salt or ester thereof and (b) picloram or an agriculturally acceptable salt or ester thereof provide control of undesirable vegetation in, e.g., rice, wheat, barley, triticale, oats, rye, sorghum, corn or maize, oilseed rape, vegetables, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, industrial vegetation management or rights-of-way.Type: ApplicationFiled: January 24, 2014Publication date: July 31, 2014Applicant: Dow AgroSciences LLCInventors: Norbert M. Satchivi, Monte R. Weimer
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Publication number: 20140213453Abstract: The present invention relates to a method for improving the plant growth regulation of crop plants, by applying to the plants a mixture of a plant growth regulator, and cis-jasmone, and to a composition comprising the same.Type: ApplicationFiled: September 10, 2012Publication date: July 31, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Ulrich Johannes Haas, Christoph Grimm
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Publication number: 20140213454Abstract: The present invention is directed to methods for improving drought stress tolerance of a cereal grain comprising applying an effective amount of at least one gibberellin to the cereal grain during early vegetative growth stage. The present invention is also directed to methods for improving yield of a cereal grain comprising applying an effective amount of at least one gibberellin to the cereal grain during early vegetative growth stage.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Applicant: Valent BioSciences CorporationInventors: Roger Kaiser, Eric Ott, Paul Silverman, Jim Wargo, Neil Badenhop, Subbaiah Chalivendra
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Publication number: 20140213455Abstract: The disclosure provides polynucleotides, polypeptides, transgenic plants, cells and vectors useful for crop plants to augment the basal level of aluminum and heavy metal tolerance.Type: ApplicationFiled: May 9, 2012Publication date: July 31, 2014Inventor: Paul Brian Larsen
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Publication number: 20140213456Abstract: 4-Amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid and agriculturally acceptable esters or salts thereof are used in methods for selective post-emergent control of undesirable vegetation in the presence of sunflowers, sorghum, yellow mustard, spring Juncea canola, spring kale, spring turnip, spring rutabaga, spring Winfred forage brassica, or sugar beet.Type: ApplicationFiled: January 24, 2014Publication date: July 31, 2014Applicant: DOW AGROSCIENCES LLCInventors: Rory Degenhardt, Len Juras, Bill McGregor, Peter Nott, Norbert M. Satchivi, Monte R. Weimer
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Publication number: 20140213457Abstract: An herbicidal concentrate composition that contains Prodiamine herbicide for application to a granular carrier such as a fertilizer granule, or a granule to be mixed with granular fertilizer.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Inventor: Lawrence A Miller
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Publication number: 20140213458Abstract: A superconducting coil body and a superconducting device are provided so as to achieve reduction of loss. A superconducting coil body includes: an inner circumferential coil body serving as a coil main body portion in which a superconducting wire is wound; and a first magnetic body serving as a magnetic circuit member. The magnetic circuit member is formed of a magnetic body, and is disposed to face the upper surface of the inner circumferential coil body, the upper surface being positioned at an end surface side thereof crossing a main surface of the superconducting wire in the inner circumferential coil body. The first magnetic body is used to form a magnetic circuit for permitting magnetic flux, which is generated by a current flowing in the coil main body portion, to travel around the current.Type: ApplicationFiled: August 24, 2012Publication date: July 31, 2014Applicant: SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Yuuichi Nakamura, Satoshi Arakawa, Tsuyoshi Shinzato, Hitoshi Oyama
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Publication number: 20140213459Abstract: The present invention relates to methods for improving the folding stability of antibodies, to antibodies with improved folding stability, nucleic acid and vectors encoding such antibodies, and to uses of such antibodies, nucleic acid and vectors.Type: ApplicationFiled: May 29, 2012Publication date: July 31, 2014Inventor: Roland Beckmann
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Publication number: 20140213460Abstract: Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof.Type: ApplicationFiled: July 3, 2012Publication date: July 31, 2014Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Jeannie T. Lee, Yesu Jeon
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Publication number: 20140213461Abstract: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.Type: ApplicationFiled: August 12, 2013Publication date: July 31, 2014Applicant: Complete Genomics, Inc.Inventors: Radoje Drmanac, Matthew J. Callow
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Publication number: 20140213462Abstract: The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe.Type: ApplicationFiled: January 28, 2014Publication date: July 31, 2014Applicant: Keygene N.V.Inventors: Michael Josephus Theresia VAN EIJK, Henricus Johannes Adam Van Der Poel
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Publication number: 20140213463Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: Harlan S. Robins, Edus H. Warren, III, Christopher Scott Carlson
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Publication number: 20140213464Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array.Type: ApplicationFiled: April 4, 2014Publication date: July 31, 2014Applicant: ILLUMINA, INC.Inventors: John Bridgham, Kevin Corcoran, George Golda, Michael C. Pallas, Sydney Brenner
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Publication number: 20140213465Abstract: Provided herein are methods and compositions for the in vitro formation of an array of plaque particles for use in biological assays, diagnosis, drug discovery and drug development. More specifically, the embodiments described herein relate to the in vitro synthesis of plaque particles when treated with biofluids and identification of such plaque particles by a variety of detection systems. In particular, the resulting in vitro plaque particles resemble atherosclerotic and amyloid plaques. The plaque embodiments described may be used to enable rapid, sensitive and/or efficient drug discovery, medical diagnostics and patient stratification.Type: ApplicationFiled: November 21, 2012Publication date: July 31, 2014Applicant: PLAXGEN, INC.Inventor: Shanmugavel Madasamy
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Publication number: 20140213466Abstract: The present invention provides methods for high-throughput assessment of in vivo skin sensitizing activity of chemical compounds through detection of secretion levels of cytokine markers implicated in skin sensitization in combination with a multivariate analysis, using support vector machine (SVM) for feature selection. The invention includes a computational algorithm that will provide unbiased analysis on the skin cell secretome data and predict the level of skin sensitization. The invention allows accurate assessment of the level sensitizing potency of any chemicals in a high-throughput manner, which can eliminate the needs for animal experiments, potentially saving money and time.Type: ApplicationFiled: November 18, 2011Publication date: July 31, 2014Applicant: Rutgers, The State University of New JerseyInventors: Rene S. Schloss, Martin L. Yarmush, Tim Maguire, Dave Xu Dong, Serom Lee
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Publication number: 20140213467Abstract: Compositions and methods which indicate an increased risk for pancreatic carcinoma in a test subject are disclosed.Type: ApplicationFiled: March 19, 2012Publication date: July 31, 2014Inventor: Anthony T. Yeung
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Publication number: 20140213468Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.Type: ApplicationFiled: November 1, 2013Publication date: July 31, 2014Inventors: Joel R.L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
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Publication number: 20140213469Abstract: The compositions and methods described are directed to gene chips having a plurality of different oligonucleotides with specificity for genes associated with autism spectrum disorders. The invention further provides methods of identifying gene profiles for neurological and psychiatric conditions including autism spectrum disorders, methods of treating such conditions, and methods of identifying therapeutics for the treatment of such neurological and psychiatric conditions.Type: ApplicationFiled: November 7, 2013Publication date: July 31, 2014Applicant: The George Washington UniversityInventor: Valerie Hu
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Publication number: 20140213470Abstract: BAFF plays a central role in acquired immunity. The disclosure identifies BAFF responsive genes that are substantially upregulated by administration of BAFF and substantially downregulated by treatment with a BAFF antagonist. Specific genes are NF-?B2, CD23, H2-M? (the beta chain of H2-DM), Fig-1, and OBF-1. The disclosure provides methods and compositions for monitoring the activity of a BAFF antagonist in a mammal; monitoring BAFF activity in a mammal; identifying a mammal to be treated with a BAFF antagonist; and related uses. Such methods include detecting one or more molecules selected from the group consisting of Fig-1 molecule, OBF-1 molecule, and H2-M? molecule in a biological sample of the mammal, and optionally further detecting NF-?B2 molecule and/or CD23 molecule in the biological sample.Type: ApplicationFiled: November 21, 2013Publication date: July 31, 2014Applicants: GENENTECH, INC., BIOGEN IDEC MA INC.Inventors: Yen-Ming Hsu, Leonid Gorelik, Tatiana Novobrantseva, Joanne Quan, Flavius Martin, Susan L. Kalled
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Publication number: 20140213471Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.Type: ApplicationFiled: January 23, 2014Publication date: July 31, 2014Applicant: California Institute of TechnologyInventors: Aditya RAJAGOPAL, Mark D. GOLDBERG, Erika F. GARCIA, Xiomara L. MADERO, Thomas A. TOMBRELLO, Axel SCHERER
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Publication number: 20140213472Abstract: A method for predicting the response to treatment in a patient suffering from a head or neck cancer including: obtaining a biological sample for the patient; measuring the expression level of several gene and using the measurement to predict a patient's response to treatment. The methods may include predicting the treatment response in a patient having virally-induced head or neck cancer; and/or using the prediction to treat the patient.Type: ApplicationFiled: January 28, 2014Publication date: July 31, 2014Applicant: William Beaumont HospitalInventors: JAN A. AKERVALL, Bryan J. Thibodeau, George D. Wilson
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Publication number: 20140213473Abstract: The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.Type: ApplicationFiled: February 27, 2014Publication date: July 31, 2014Inventors: Kousik Kundu, Nisha Padhye, William Volcheck
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Publication number: 20140213474Abstract: Provided here in are, inter alia, methods of determining whether a patient is resistant or sensitive to glucocorticoid therapy.Type: ApplicationFiled: March 11, 2014Publication date: July 31, 2014Applicant: Shriners Hospitals for ChildrenInventors: Kiho Cho, David G. Greenhalgh
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Publication number: 20140213475Abstract: The invention features methods of diagnosing cancer in a mammal (e.g., a human) by detecting a biomarker selected from a satellite II ribonucleic acid (RNA) molecule, a cancer-associated polycomb group (CAP) body, a cancer-associated satellite transcript (CAST) body, and UbH2A. Also featured is a method for identifying an agent for treating cancer in a mammal by contacting a cancer cell having a biomarker selected from a CAP body, a CAST body, and a satellite II RNA molecule with a test agent and determining whether the test agent reduces the level of the biomarker in the cancer cell. Other inventions featured are a method for determining whether a chemotherapeutic agent increases epigenetic imbalance of a cell and a method for detecting epigenetic imbalance by determining a copy number of a satellite II DNA locus at chromosome 1q12 in a cell.Type: ApplicationFiled: July 16, 2012Publication date: July 31, 2014Applicant: University of MassachusettsInventors: Jeanne B. Lawrence, Lisa Hall, Meg Byron, Dawn M. Carone