Patents Issued in November 15, 2018
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Publication number: 20180327857Abstract: The present invention relates to a diagnostic biomarker, a method for identifying the diagnostic biomarker, and a diagnostic method using the diagnostic biomarker. Specifically, the present invention uses a ratio of ncRNAs as a diagnostic biomarker, identifies optimal ncRNAs pair associated with diseases based on SVM-RFE algorithm, and then uses the same for diagnosis of the diseases.Type: ApplicationFiled: March 19, 2018Publication date: November 15, 2018Inventors: Youping DENG, Hongwei WANG
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Publication number: 20180327858Abstract: The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample.Type: ApplicationFiled: May 1, 2018Publication date: November 15, 2018Inventors: Bert Vogelstein, Kenneth W. Kinzler
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Publication number: 20180327859Abstract: A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, SOX17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases.Type: ApplicationFiled: May 4, 2018Publication date: November 15, 2018Inventors: Manon Van Engeland, Manon Adriaan De Bruine, Arjan Griffioen, Joost Louwagie, Katja Bierau, Gontran Brichard, Gaetan Otto, Maarten Penning
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Publication number: 20180327860Abstract: Methods for identifying or diagnosing AKT inhibitor resistant cancers and methods an compositions for treating.Type: ApplicationFiled: May 8, 2018Publication date: November 15, 2018Applicant: GENENTECH, INC.Inventor: Kui Lin
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Publication number: 20180327861Abstract: Different combinations of methylation status based biomarkers can be used to test for prostate cancer with high sensitivity and high specificity.Type: ApplicationFiled: May 10, 2018Publication date: November 15, 2018Inventors: Vladimir Bajic, Hicham Mansour, Roberto Incitti
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Publication number: 20180327862Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.Type: ApplicationFiled: May 14, 2018Publication date: November 15, 2018Inventors: AmirAli TALASAZ, HELMY ELTOUKHY
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Publication number: 20180327863Abstract: Two genes, ARID1A (AT-rich interactive domain-containing protein 1A) and PPP2R1A (protein-phosphatase 2, regulatory subunit 1, alpha), can be used in methods which are useful for detecting cancer, diagnosing cancer, contributing to a diagnosis of cancer, confirming a diagnosis of cancer, identifying appropriate treatments for cancer, monitoring treatment of cancer, and evaluating treatment protocols for cancer, including ovarian clear cell carcinoma, breast cancer, colon cancer, gastric cancer, lung cancer, medulloblastoma, pancreatic cancer, and prostate cancer.Type: ApplicationFiled: May 23, 2018Publication date: November 15, 2018Inventors: Bert Vogelstein, Kenneth W. Kinzler, Victor Velculescu, Nickolas Papadopoulos, Sian Jones
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Publication number: 20180327864Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. The invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-CBL.Type: ApplicationFiled: May 25, 2018Publication date: November 15, 2018Inventors: Ravi Salgia, Soundarajan Krishnaswamy, Yi-Hung Carol Tan, Suvobroto Nandi
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Publication number: 20180327865Abstract: A next generation sequencing (NGS) based method includes applying, for one or more genetic loci, respective NGS data for genotype of a first subject, genotype of a second subject, and genotype of an alleged offspring of the first and second subjects to a statistical model calculating a value representing a likelihood the offspring is a true offspring of the first and second subjects. The NGS data includes genotype and sequencing read of the first tested subject; genotype and sequencing read of the second tested subject; and genotype and sequencing read of the alleged offspring. The statistical model utilizes a probability of the genotype of the first tested subject in a subject population; a probability of the genotype of the second tested subject in a subject population; and a probability of the genotype of the alleged offspring in a subject population.Type: ApplicationFiled: May 9, 2017Publication date: November 15, 2018Inventors: Zicheng Zhao, Bowen Tan, Shuai Cheng Li
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Publication number: 20180327866Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).Type: ApplicationFiled: July 18, 2018Publication date: November 15, 2018Inventors: Christina Fan, Stephen P.A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
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Publication number: 20180327867Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).Type: ApplicationFiled: July 18, 2018Publication date: November 15, 2018Inventors: Christina Fan, Stephen P.A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
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Publication number: 20180327868Abstract: The invention relates to a method for quantifying levels of expression and/or quantifying copy number of a heterologous polynucleotide in a transgenic plant using quantitative or real-time polymerase chain reaction (QPCR or real-time PCR), wherein the real-time PCR is performed using a primer set specific to a heterologous terminator sequence operably linked to the heterologous polynucleotide.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: IGOR CUNHA DE OLIVEIRA, DENNIS O'NEILL, ANDREW SLATTERY, JIJUN ZOU
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Publication number: 20180327869Abstract: A method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.Type: ApplicationFiled: November 12, 2015Publication date: November 15, 2018Applicant: CAMBRIDGE ENTERPRISE LIMITEDInventor: Bryn Hardwick
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Publication number: 20180327870Abstract: Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicant: The Government of the USA as represented by the Secretary of the Dept. of Health & Human ServicesInventors: Stephen Lindstrom, Lamorris Loftin
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Publication number: 20180327871Abstract: A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).Type: ApplicationFiled: July 25, 2018Publication date: November 15, 2018Inventors: Crystal Marie Anderson-Cunanan, Daniel J. Foster, Ray McCarthy, Mary M. Byron, David Robert Wulfman, Bradley S. Swehla
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Publication number: 20180327872Abstract: A device for providing selective heat treatment on a metal sheet comprising boron steel is provided. The device comprises a laser source for emitting a laser beam onto the metal sheet to provide a selective heat treatment thereon, wherein a defined heat treated grid pattern is formed on the metal sheet by the selective heat treatment. The device further comprises a control unit arranged to control the operation of the laser source for providing the defined heat treated pattern onto the metal sheet; and control the case hardness depth of the defined heat treated pattern based on a temperature parameter and a holding time parameter associated with the operation of the laser source. A method for performing controlling the case hardness depth of a selectively heat treated metal sheet of boron steel is also provided.Type: ApplicationFiled: November 13, 2015Publication date: November 15, 2018Inventors: Christer SVENSSON, Nader ASNAFI
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Publication number: 20180327873Abstract: An engineering steel including (in wt.-%) up to 0.25% C, up to 0.45% Si, 0.20-2.00% Mn, up to 4.00% Cr, 0.6-3.0% Mo, 0.004-0.020% N, up to 0.40% S. 0.001-0.035% Al, 0.0005-0.0025% B, up to 0.015% Nb, up to 0.01% Ti, up to 0.10% V, up to 1.5% Ni and up to 2.0% Cu, remainder iron and unavoidable impurities, wherein the Al content % Al, the Nb content % Nb, the Ti content % Ti, the V content % V and the N content % N meet the following condition: % Al/27+% Nb/45+% Ti/48+% V/25>% N/3.75. The steel has a yield strength of at least 750 MPa, a tensile strength of at least 950 MPa and a structure having at least 80 vol.-% bainite and a total of a maximum of 20 vol.-% of retained austenite, ferrite, perlite and/or martensite.Type: ApplicationFiled: November 15, 2016Publication date: November 15, 2018Inventors: Ulrich Reichel, Till Schneiders, Frank van Soest, Hans-Günter Krull
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Publication number: 20180327874Abstract: A gas quenching method of the present invention includes a first stage (t1 to t2) at which a workpiece is subjected to a rapid cooling by forcibly circulating a cooling gas, a second stage (t2 to t3) at which the circulation of the cooling gas is stopped and pressure is reduced inside the furnace to conduct heat insulation, and a third stage (as from t3) at which the workpiece is cooled again by the cooling gas. At the second stage, the workpiece is maintained at an intermediate temperature that is higher than martensite transformation start temperature, and, during this, temperature throughout the workpiece is made uniform. Therefore, it is possible to achieve a uniform quenching and suppress distortion caused by difference of the cooling speed.Type: ApplicationFiled: November 11, 2015Publication date: November 15, 2018Applicant: NISSAN MOTOR CO., LTD.Inventors: Tsuyoshi SUGIMOTO, Yukichi OKAYAMA
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Publication number: 20180327875Abstract: Provided is a high strength steel machine part. A method for manufacturing a machine part comprises the steps of: preparing a workpiece of steel to be a machine part; and subjecting the workpiece to a quenching process by heating a surface portion of the workpiece, with shear strain applied to the surface portion, to a heating temperature of an A3 transformation point temperature or higher, and subsequently cooling the surface portion. The workpiece has a carbon content of 0.2 mass % or more. In the step of subjecting the workpiece to a quenching process, the heating temperature is 800° C. or higher, and in the quenching process the workpiece has the surface portion cooled at a rate of 35° C./second or faster for a temperature range of 850° C. to 300° C.Type: ApplicationFiled: June 3, 2016Publication date: November 15, 2018Inventors: Miyu SATO, Chikara OHKI
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Publication number: 20180327876Abstract: The invention relates to a continuous flow cooling device (3) for cooling a metal strip (1), in particular a metal strip made of aluminum or an aluminum alloy, having at least one strip flotation cooler (4), which has several upper nozzles (5) distributed along the strip travel direction (B), and several lower nozzles (6) distributed along the strip travel direction (B), wherein the metal strip (1) can be transported in a floating manner between the upper nozzles (5) and the lower nozzles (6), and the upper side of the strip as well as the underside of the strip can be supplied with cooling air in the process, and having several water cooling units (7), by means of which the metal strip (1) can be supplied with cooling water. This device is characterized in that the water cooling units (7) are integrated in the strip flotation cooler (4).Type: ApplicationFiled: January 10, 2017Publication date: November 15, 2018Inventors: Dirk SCHAEFER, Andreas NOE, Thomas VONDEROHE
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Publication number: 20180327877Abstract: A low-alloy and corrosion-resistant steel for a vehicle, may include about 0.001 wt % to about 0.1 wt % of C, about 0.01 wt % to about 0.5 wt % of Si, about 0.1 wt % to about 0.6 wt % of Mn, more than 0 wt % and about 0.18 wt % or less of P, more than 0 wt % and less than about 0.02 wt % of S, about 0.001 wt % to about 0.03 wt % of Nb, more than 0 wt % and about 0.03 wt % or less of Cr, about 0.05 wt % to about 0.3 wt % of Cu, about 0.05 wt % to about 0.2 wt % of Ni, and more than 0 wt % and about 0.2 wt % or less of a combined weight of Sn and Sb, and the balance iron and inevitable impurities.Type: ApplicationFiled: November 1, 2017Publication date: November 15, 2018Applicants: Hyundai Motor Company, Kia Motors Corporation, Hyundai Steel CompanyInventors: Jae-Woong CHOI, Won-Seok YANG
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Publication number: 20180327878Abstract: This high strength hot rolled steel sheet has a predetermined chemical composition, in which the structure of the high strength hot rolled steel sheet contains martensite in an area ratio of 20% or more and 60% or less and ferrite in an area ratio of 40% or more, and the total area ratio of the martensite and the ferrite is 90% or more, the average grain size of the martensite is 5.0 ?m or more and 50 ?m or less, the ratio of the hardness of the martensite to the hardness of the ferrite is 0.6 or more and 1.6 or less, and the tensile strength of the high strength hot rolled steel sheet is 980 MPa or more.Type: ApplicationFiled: November 19, 2015Publication date: November 15, 2018Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Takeshi TOYODA, Daiki KAMADA, Yuuki KANZAWA, Mayuko KIKUZUKI
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Publication number: 20180327879Abstract: The present invention relates to a grain-oriented electrical steel sheet and a method for manufacturing the same. The grain-oriented electrical steel sheet contains 2.0 wt % or more to 5.0 wt % or less of Si, 0.005 wt % or more to 0.04 wt % or less of acid-soluble Al, 0.01 wt % or more to 0.2 wt % or less of Mn, 0.01 wt % or less (excluding 0 wt %) of N, 0.01 wt % or less (excluding 0 wt %) of S, 0.01 wt % or more to 0.05 wt % or less of Sb, 0.02 wt % or more to 0.08 wt % or less of C, 0.0005 wt % or more to 0.045 wt % or less of P, 0.03 wt % or more to less than 0.08 wt % of Sn, and 0.01 wt % or more to 0.2 wt % or less of Cr, and contains balance Fe and other inevitable impurities.Type: ApplicationFiled: November 9, 2016Publication date: November 15, 2018Applicant: POSCOInventors: Dae Hyun SONG, June Soo PARK
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Publication number: 20180327880Abstract: A method of producing a steel material, wherein when a cooling apparatus having a plurality of cooling sections disposed side by side in a longitudinal direction of a steel material cools the steel material hot worked or cooled/reheated, the steel material is conveyed at a conveyance distance Lo (m) satisfying Equation (1), in one direction along with the longitudinal direction of the steel material, in the cooling apparatus, wherein Lo is defined as conveyance distance (m) of steel material, m is a natural number, and Lh is defined as length (m) of cooling sections in longitudinal direction of steel material: (m?0.20)×Lh?Lo?(m+0.20)×Lh??(1).Type: ApplicationFiled: May 2, 2016Publication date: November 15, 2018Inventors: Kenji Okushiro, Hiroyuki Fukuda, Hideo Kijima, Yoshikazu Yoshida, Hiroshi Ishikawa, Sadanori Nakano
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Publication number: 20180327881Abstract: A seamless steel pipe having a specific chemical composition. A ratio of Ti to N is in a range of 2.0 to 5.0. The steel pipe has a microstructure including tempered martensite having a volume ratio of 95% or more, and prior austenite grains having a grain size number of 8.5 or more. In a cross-section perpendicular to a rolling direction of the steel pipe a number of nitride-based inclusions having a particle size of 4 um or more is 100 or less per 100 mm2, a number of nitride-based inclusions having a particle size of less than 4 ?m is 1000 or less per 100 mm2, a number of oxide-based inclusions having a particle size of 4 ?m or more is 40 or less per 100 mm2, and a number of oxide-based inclusions having a particle size of less than 4 ?m is 400 or less per 100 mm2.Type: ApplicationFiled: August 20, 2015Publication date: November 15, 2018Applicant: JFE STEEL CORPORATIONInventors: Masao YUGA, Yasuhide ISHIGURO, Mitsuhiro OKATSU, Seiji NABESHIMA, Hiroki OTA
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Publication number: 20180327882Abstract: A process for controlling austenite grain size in austenite processing through nano-scale precipitate engineering of TiN—NbC composites to produce thicker gage product of niobium microalloyed line pipe steel that includes controlling the base chemistry of the steel to include 0.003-0.004 wt. % nitrogen, 0.012-0.015 wt. % titanium, 0.03-0.07 wt. % carbon, and 0.07-0.15 wt. % niobium; conducting a first stage of roughing above the temperature of dissolution of NbC to refine austenite grain size by static recrystallization below 30 microns, cooling so that the center of the thick rolled slab is about 1040° C., conducting a second stage of roughing to promote strain induced growth of NbC on pre-existing TiN to form TiN—NbC composites to increase Zener pinning pressure on austenite grain boundaries to about 0.1 MPa in order to prevent recrystallization and grain coarsening of austenite grains beyond 30 microns at the end of roughing, and conducting finish rolling below 920° C.Type: ApplicationFiled: July 6, 2018Publication date: November 15, 2018Inventor: Sundaresa Venkata Subramanian
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Publication number: 20180327883Abstract: A method for producing a non-oriented electrical steel sheet by hot rolling a steel slab having a chemical composition including C: not more than 0.0050 mass %, Si: not more than 4.0 mass %, Mn: 0.03-3.0 mass %, P: not more than 0.1 mass %, Se: not more than 0.0010 mass %, Al: not more than 3.0 mass %, Ni: not more than 3.0 mass %, Cr: not more than 5.0 mass %, Ti: not more than 0.003 mass %, and Nb: not more than 0.003 mass % and subjecting the sheet to hot band annealing if necessary, a cold rolling, and further a finish annealing, wherein the heating in the finish annealing is conducted in two stages of performing induction heating and subsequently a radiation heating and a zone from 600° C. to 740° C. in the induction heating is heated at an average heating rate of not less than 50° C./sec, whereby a high magnetic flux density can be obtained stably.Type: ApplicationFiled: October 3, 2016Publication date: November 15, 2018Applicant: JFE STEEL CORPORATIONInventors: Yoshiaki ZAIZEN, Tomoyuki OKUBO, Yoshihiko ODA
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Publication number: 20180327884Abstract: A high-strength galvanized steel sheet and a method for producing the steel sheet. The steel sheet has a composition that includes C: 0.030% to 0.250%, Si: 0.01% to 3.00%, Mn: 2.00% to 10.00%, P: 0.001% to 0.100%, S: 0.0001% to 0.0200%, N: 0.0005% to 0.0100%, Ti: 0.005% to 0.200%, on a mass basis, and Fe and inevitable impurities. Additionally, the steel sheet has concentration of solute Mn at a depth of 5 ?m or less from a surface of the steel sheet that is 1.50% by mass or less, and a value obtained by dividing the average mass percentage of Mn in retained austenite by the average mass percentage of Mn in ferrite is 2.0 or more.Type: ApplicationFiled: November 8, 2016Publication date: November 15, 2018Applicant: JFE STEEL CORPORATIONInventors: Mai AOYAMA, Minoru TANAKA, Yoshitsugu SUZUKI, Yoshiyasu KAWASAKI, Hideyuki TAKAHASHI
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Publication number: 20180327885Abstract: A method for reducing impurities in magnesium comprises: combining a zirconium-containing material with a molten low-impurity magnesium including no more than 1.0 weight percent of total impurities in a vessel to provide a mixture; holding the mixture in a molten state for a period of time sufficient to allow at least a portion of the zirconium-containing material to react with at least a portion of the impurities and form intermetallic compounds; and separating at least a portion of the molten magnesium in the mixture from at least a portion of the intermetallic compounds to provide a purified magnesium, wherein the purified magnesium includes an increased level of zirconium compared to the low-impurity magnesium, wherein the purified magnesium includes greater than 1000 ppm zirconium, and wherein the purified magnesium includes a reduced level of impurities other than zirconium compared to the low-impurity magnesium.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Inventors: Scott Coffin, Arnel M. Fajardo
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Publication number: 20180327886Abstract: A downhole tool includes a housing configured to be placed into a subterranean environment and a mixer disposed in the housing. The mixer includes a first inlet configured to receive a fusible metal or alloy component and a second inlet configured to receive a solid metal or semi-metal component. Additionally, the mixer includes a mixing chamber configured to mix the fusible metal or alloy component and the solid metal or semi-metal component to form a liquid or partially liquid alloy. Further, the mixer includes an outlet configured to discharge the liquid or partially liquid alloy into the subterranean environment. The liquid or partially liquid alloy is configured to harden into a solid alloy over time.Type: ApplicationFiled: May 10, 2017Publication date: November 15, 2018Inventor: Manuel Marya
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Publication number: 20180327887Abstract: Refractory metal alloy targets for reducing particles in physical vapor deposition processing and refractory metal-based layer for integrated circuit applications (for example, crystallization barrier layers in non-volatile memory devices) are disclosed herein. An exemplary method for reducing particles in a PVD chamber include positioning a refractory metal alloy target in the PVD chamber, positioning a substrate in the PVD chamber a distance from the refractory metal alloy target, and sputtering material from the refractory metal alloy target to form a refractory metal-based layer over the substrate. The refractory metal alloy target includes a refractory metal (for example, tungsten or molybdenum) alloyed with a body-centered cubic (BCC) metal (for example, niobium, tantalum, vanadium, or a combination thereof). The BCC metal has a Young's modulus lower than a Young's modulus of the refractory metal.Type: ApplicationFiled: December 18, 2015Publication date: November 15, 2018Applicant: Intel CorporationInventors: Christopher J. WIEGAND, Philip YASHAR, Anurag CHAUDHRY
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Publication number: 20180327888Abstract: A method of forming a supporting substrate for a cutting element comprises forming a precursor composition comprising discrete WC particles, a binding agent, and discrete particles comprising Co, one or more of Al, Be, Ga, Ge, Si, and Sn, and one or more of C and W. The precursor composition is subjected to a consolidation process to form a consolidated structure including WC particles dispersed in a homogenized binder comprising Co, W, C, and one or more of Al, Be, Ga, Ge, Si, and Sn. A method of forming a cutting element, a cutting element, a related structure, and an earth-boring tool are also described.Type: ApplicationFiled: December 14, 2017Publication date: November 15, 2018Inventors: Wanjun Cao, Marc W. Bird
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Publication number: 20180327889Abstract: Provided is a steel wire rod for wire drawing containing, in terms of % by mass, C: from 0.90 to 1.20%, Si: from 0.10 to 1.30%, Mn: from 0.20 to 1.00%, Cr: from 0.20 to 1.30%, Al: from 0.005 to 0.050%, and the balance being composed of Fe and impurities, wherein a content of each N, P, and S, which are contained as the impurities, is N: from 0.0070% or less, P: from 0.030% or less, S: from 0.010% or less, and the steel wire rod having a metallographic structure of which 95% or more by volume ratio is a lamellar pearlite structure, wherein the lamellar pearlite structure has an average lamellar spacing of from 50 to 75 nm, an average length of cementites in the lamellar pearlite structure is 1.0 to 4.0 ?m, and a percentage of a number of cementites having a length of 0.5 ?m or less among the cementites in the lamellar pearlite structure is 20% or less.Type: ApplicationFiled: October 20, 2016Publication date: November 15, 2018Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Toshihiko TESHIMA, Yoshihiro DAITO, Toshiyuki MANABE
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Publication number: 20180327890Abstract: The present disclosure concerns embodiments of aluminum alloy compositions exhibiting superior microstructural stability and strength at high temperatures. The disclosed aluminum alloy compositions comprise particular combinations of components that contribute the ability of the alloys to exhibit improved microstructural stability and hot tearing resistance as compared to conventional alloys. Also disclosed herein are embodiments of methods of making and using the alloys.Type: ApplicationFiled: May 12, 2017Publication date: November 15, 2018Inventors: Amit Shyam, James A. Haynes, Adrian S. Sabau, Dongwon Shin, Yukinori Yamamoto, Christopher R. Glaspie, Jose A. Gonzalez-Villarreal, Seyed Mirmiran, Andres F. Rodriguez-Jasso
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Publication number: 20180327891Abstract: Device for spray coating embraces a wire arc spray head that includes arc-making contact points and a carrier gas outlet, which is configured to swivel with feed wire in a pivoting motion. The device can be operated to spray coat a work piece.Type: ApplicationFiled: April 26, 2018Publication date: November 15, 2018Inventors: Alexander D. Stevenson, Robert Anthony McDemus
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Publication number: 20180327892Abstract: An article comprises a body having a coating. The coating comprises a Y—O—F coating or other yttrium-based oxy-fluoride coating generated either by performing a fluorination process on a yttrium-based oxide coating or an oxidation process on a yttrium-based fluorine coating.Type: ApplicationFiled: April 27, 2018Publication date: November 15, 2018Inventors: Xiaowei Wu, David Fenwick, Guodong Zhan, Jennifer Y. Sun, Michael R. Rice
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Publication number: 20180327893Abstract: A magnetron sputter reactor for sputtering deposition materials such as tantalum, tantalum nitride and copper, for example and its method of use, in which self-ionized plasma (SIP) sputtering and inductively coupled plasma (ICP) sputtering are promoted, either together or alternately, in the same or different chambers. Also, bottom coverage may be thinned or eliminated by ICP resputtering in one chamber and SIP in another. SIP is promoted by a small magnetron having poles of unequal magnetic strength and a high power applied to the target during sputtering. ICP is provided by one or more RF coils which inductively couple RF energy into a plasma. The combined SIP-ICP layers can act as a liner or barrier or seed or nucleation layer for hole. In addition, an RF coil may be sputtered to provide protective material during ICP resputtering. In another chamber an array of auxiliary magnets positioned along sidewalls of a magnetron sputter reactor on a side towards the wafer from the target.Type: ApplicationFiled: July 11, 2018Publication date: November 15, 2018Inventors: Peijun DING, Rong TAO, Zheng XU, Daniel C. LUBBEN, Suraj RENGARAJAN, Michael A. MILLER, Arvind SUNDARRAJAN, Xianmin TANG, John C. FORSTER, Jianming FU, Roderick C. MOSELY, Fusen CHEN, Praburam GOPALRAJA
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Publication number: 20180327894Abstract: A phase-transition type vanadium oxide material and a preparation method therefor. The preparation method includes the following steps: providing a vanadium oxide base material, and implanting gaseous ions into the vanadium oxide base material, to obtain a phase-transition type vanadium oxide material having a preset phase-transition temperature. Subsequently, optionally, further annealing may be performed to adjust a bubble generation status in vanadium oxide after the gaseous ions are implanted, to further adjust the stress and strain and the phase-transition temperature. The method for preparing a phase-transition type vanadium oxide material consistent with the present invention has simple steps, desirable process reproducibility, high flexibility, and the phase-transition temperature of vanadium oxide can be continuously adjusted by changing an implantation dosage of the gaseous ions.Type: ApplicationFiled: January 6, 2016Publication date: November 15, 2018Applicant: SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: XIN OU, QI JIA, KAI HUANG, XI WANG
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Publication number: 20180327895Abstract: An evaporating apparatus includes a plurality of evaporation sources, and each includes a material chamber, a nozzle, and restriction plates disposed on both sides of each of the evaporation sources, wherein a distance and a height difference between the adjacent restriction plates limit a spray range of the nozzle between the adjacent restriction plates, each of the restriction plates is connected with a moving assembly, and each of the restriction plates is movable within a region between two of the adjacent evaporation sources via the moving assembly for adjusting the spray range of the nozzle.Type: ApplicationFiled: August 8, 2017Publication date: November 15, 2018Inventor: Junying MU
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Publication number: 20180327896Abstract: A sputtering target includes an indium cerium zinc oxide represented by In2CexZnO4+2x, wherein x=0.5˜2. A relative density of the sputtering target is larger than or equal to 90%. A bulk resistance of the sputtering target in a range from about 10?2 ?cm to about 10 ?cm. A weight percentage of crystalline In2CexZnO4+2x in the sputtering target is larger than 80%.Type: ApplicationFiled: July 13, 2018Publication date: November 15, 2018Applicants: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD., HON HAI PRECISION INDUSTRY CO., LTD.Inventors: DA-MING ZHUANG, MING ZHAO, MING-JIE CAO, LI GUO, SHI-LU ZHAN, XIAO-LONG LI
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Publication number: 20180327897Abstract: A cylindrical target assembly for use in a physical vapor deposition (PVD) processing chamber for magnetically enhanced sputtering applications. In embodiments disclosed herein, a cylindrical target, disposed around a rotatable backing tube, has one or more contoured ends that conform to a magnetic sputtering line located outside of a uniform magnetic field. The contoured ends prevent or substantially reduce the accumulation of redeposition material at either end of the cylindrical target assembly desirably reducing particle contamination in the process chamber and on the surfaces of substrates processed therein.Type: ApplicationFiled: April 24, 2018Publication date: November 15, 2018Inventor: Aki HOSOKAWA
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Publication number: 20180327898Abstract: An article comprises a body having a coating. The coating comprises a Y—O—F coating or other yttrium-based oxy-fluoride coating generated either by performing a fluorination process on a yttrium-based oxide coating or an oxidation process on a yttrium-based fluorine coating.Type: ApplicationFiled: April 27, 2018Publication date: November 15, 2018Inventors: Xiaowei Wu, David Fenwick, Guodong Zhan, Jennifer Y. Sun, Michael R. Rice
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Publication number: 20180327899Abstract: An article comprises a body having a coating. The coating comprises a Y-O-F coating or other yttrium-based oxy-fluoride coating generated either by performing a fluorination process on a yttrium-based oxide coating or an oxidation process on a yttrium-based fluorine coating.Type: ApplicationFiled: April 27, 2018Publication date: November 15, 2018Inventors: Xiaowei Wu, David Fenwick, Guodong Zhan, Jennifer Y. Sun, Michael R. Rice
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Publication number: 20180327900Abstract: A composition comprising dihydropyrazinyl anions that can be coordinated as 6 electron ligands to a broad range of different metals to yield volatile metal complexes for ALD and CVD depositions are described herein. Also described herein are undeprotonated dihydropyrazines that can coordinate to metals as stabilizing neutral ligands. In one embodiment, the composition is used for the direct liquid injection delivery of the metal dihydropyrazinyl complex precursor to the chamber of an ALD or CVD chamber for the deposition of metal-containing thin films such as, for example, ruthenium or cobalt metal films.Type: ApplicationFiled: May 9, 2018Publication date: November 15, 2018Applicant: Versum Materials US, LLCInventors: John Anthony Thomas Norman, Sergei Vladimirovich Ivanov, Xinjian Lei
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Publication number: 20180327901Abstract: There is provided a cleaning method for removing a first deposit, formed on an upper electrode through an etching of a metal layer containing a metal, by using a plasma generated between a lower electrode of a lower structure and the upper electrode in a processing chamber of a plasma processing apparatus. The method includes a step of colliding ions with the first deposit formed on the upper electrode and a step of removing a second deposit, which is generated by said colliding and formed on the lower structure. Further, a cycle including the step of colliding and the step of removing is repeated multiple times.Type: ApplicationFiled: July 24, 2018Publication date: November 15, 2018Applicant: TOKYO ELECTRON LIMITEDInventors: Hiroki KISHI, Mitsuru HASHIMOTO, Keiichi SHIMODA, Eiichi NISHIMURA, Akitaka SHIMIZU
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Publication number: 20180327902Abstract: An apparatus for the vacuum treatment of substrates in a vacuum chamber includes a substrate support device with a pylon which can be rotated about a longitudinal axis and has holding means for substrates and a plasma discharge device assigned to the pylon. The plasma discharge device includes more than two plate-shaped electrodes having excitation areas, the excitation areas of which are all oriented in the direction of the pylon and a power supply device for the excitation of a plasma discharge, by at least one electrical voltage applied to at least two of the electrodes, is provided, the excited plasma acting at least on parts of the pylon and on substrates that can be arranged on them. A process performs the vacuum coating by the apparatus.Type: ApplicationFiled: November 7, 2016Publication date: November 15, 2018Applicant: BÜHLER ALZENAU GMBHInventors: Torsten SCHMAUDER, Ludger URBAN, Wilfried DICKEN, Jutta TRUBE
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Publication number: 20180327903Abstract: A batch type processing apparatus for simultaneously processing a plurality of target objects to be processed, includes a main chamber; a plurality of stages, arranged in the main chamber in a height direction of the main chamber, for mounting thereon the target objects; and a plurality of covers, provided to the stages, for covering the target objects mounted on the stages. The stages and the covers surround the target objects mounted on the stages, thereby forming small processing spaces each of which has a capacity smaller than a capacity of the main chamber.Type: ApplicationFiled: July 20, 2018Publication date: November 15, 2018Applicant: Tokyo Electron LimitedInventors: Tsutomu Satoyoshi, Hiroshi Ishida
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Publication number: 20180327904Abstract: A film forming apparatus includes a mounting table on which a substrate is mounted; a ceiling plate facing the mounting table, the ceiling plate defining a processing space between the ceiling plate and mounting table; and a gas supply mechanism configured to supply a source gas to the processing space horizontally with respect to the substrate. A facing surface of the ceiling plate or a facing surface of the mounting table is inclined such that a gap between the facing surfaces of the mounting table and the ceiling plate becomes wider at a downstream side than at an upstream side in a flow direction of the source gas.Type: ApplicationFiled: May 7, 2018Publication date: November 15, 2018Inventor: Kazuki DEMPOH
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Publication number: 20180327905Abstract: Disclosed herein are implementations of a particles-transferring system, particle transferring unit, and method of transferring particles in a pattern. In one implementation, a particles-transferring system includes a first substrate including a first surface to support particles in a pattern, particle transferring unit including an outer surface to be offset from the first surface by a first gap, and second substrate including a second surface to be offset from the outer surface by a second gap. The particle transferring unit removes the particles from the first surface in response to the particles being within the first gap, secures the particles in the pattern to the outer surface, and transports the particles in the pattern. The second substrate removes the particles in the pattern from the particle transferring unit in response to the particles being within the second gap. The particles are to be secured in the pattern to the second surface.Type: ApplicationFiled: May 10, 2017Publication date: November 15, 2018Inventors: Yunda Wang, Sourobh Raychaudhuri, JengPing Lu, Eugene M. Chow, Julie A. Bert, David Biegelsen, George A. Gibson, Jamie Kalb
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Publication number: 20180327906Abstract: A film forming apparatus includes a rotary table having a loading area at a first surface side thereof and revolving a substrate loaded on the loading area, a rotation mechanism rotating the loading area such that the substrate rotates around its axis, a processing gas supply mechanism supplying a processing gas to a processing gas supply area so that a thin film is formed on the substrate which repeatedly passes through the processing gas supply area the revolution of the substrate, and a control part configured to perform a calculation of a rotation speed of the substrate based on a parameter including a rotation speed of the rotary table to allow an orientation of the substrate to be changed whenever the substrate is positioned in the processing gas supply area, and to output a control signal for rotating the substrate at a calculated rotation speed.Type: ApplicationFiled: June 28, 2018Publication date: November 15, 2018Inventors: Hitoshi KATO, Shigehiro MIURA, Hiroyuki KIKUCHI, Katsuyoshi AIKAWA