Abstract: A fluid control device includes a tube insertion portion formed in a casing, a fixing member that fixedly holds, in the tube insertion portion, a tube inserted into the tube insertion portion, a pressing member driven by an actuator to press the tube within the tube insertion portion, and a controller that controls the actuator for the pressing member, wherein the controller controls the pressing member to start pressing on the tube after the fixing member has fixedly hold the tube in the tube insertion portion.

Abstract: An anesthesiology pump for automatic delivery and control of anesthetics to a patient provides a remote unit that may be carried by an anesthesiologist to improve supervision of the anesthesiology process without unnecessarily constraining the anesthesiologist's movement. The anesthesiology pump may assess one or both of a status of the anesthesiology procedure and the availability of the anesthesiologist to provide tailored alerts to the anesthesiologist when additional attention or availability may be needed. Availability may consider separation distance between the pump and the radiologist as well as express indications of availability. A set of predefined safe states permit a pump response when the anesthesiologist is not available and additional attention is required.

Abstract: A method may include displaying to a user an interface at which the user inputs a fear of hypoglycemia index (FHI), the FHI corresponding to an acceptable probability of a blood glucose level being below a threshold blood glucose level. The method may also include receiving blood glucose data for a person with diabetes (PWD). The method may additionally include calculating a probability of the PWD having a blood glucose level below the threshold blood glucose level based on the variability of the received blood glucose data. The method may also include setting one or more target blood glucose levels to align the probability of the PWD having a blood glucose level below the threshold blood glucose level with the acceptable probability associated with the user input FHI. The method may additionally include delivering insulin, using the insulin delivery device, based on the target blood glucose level.

Abstract: A supplemental device configured for attachment to an injection device, the supplemental device comprising: a camera configured to generate camera output indicative of a scene viewable by the camera, and to be located on an optical path with a surface of an injection device attached to the supplemental device in use; a light source having an emission spectrum and configured to illuminate the surface with light within the emission spectrum in use; and a filter configured to be located on the optical path between the camera and the surface in use, the filter being substantially opaque to light across the entire emission spectrum of the light source and substantially transparent to light of at least one frequency outside the emission spectrum of the light source.

Abstract: A needle assembly (14), for use with a syringe (3) and a medicine cartridge (12); has a molded body (14B). A needle (14A) is housed in, affixed to, and reinforced by the molded body (14B). The needle (14A) has a single tube which includes a tip (311), and a tip-ward needle (31) extending ring-ward from said tip into the molded body (14B). The tip-ward needle becomes a cartridge needle (531) within the molded body (14B). The cartridge needle (531) extends tip-ward from the molded body (14B). The molded body (14B), is molded as a single structure, and includes: a domed cylinder (248), at the molded body (14B)'s tip-ward end; a flange (22) ringward of the molded body (14B); and fins (251). The fins are molded radially from the domed cylinder (248). The fins are vertically molded from the flange (22); and reinforce the fins to the flange. A second cylinder (244), is extended ringward from the flange (22). A conical portion (15) is molded ringward from the second cylinder (244).

Abstract: The present Invention relates to a kit for applying a liquid composition on or in the skin, comprising an injection device and one or more cartridges, provided with a container appropriate for receiving a liquid composition, in which the injection device is provided with means for receiving a cartridges, characterized in that the container is provided with a movable body. The cartridge is provided with a peripheral edge, that allows the safe removal of a used cartridge out of the device, In a second aspect, the invention relates to a method for applying a liquid composition onto the skin.

Abstract: A needleless syringe comprises a main syringe body which is a main body thereof and which has, in the main body, a sliding movement passage connected to an opening provided on a front end surface of the main body; a holding unit which has an accommodating unit for accommodating an injection objective substance so that the injection objective substance is releasable; and a driver that is configured to apply energy to the holding unit in order to allow the holding unit to slide toward the opening. When the energy is applied by the driver to the holding unit disposed at the initial position, the holding unit slides in the sliding movement passage to abut against the opening at the abutment position, and thus the injection objective substance accommodated in the accommodating unit is discharged via the opening. Accordingly, the high injection performance of the needleless syringe is appropriately exhibited.

Abstract: The invention relates to an electronic module for recording information of a drug delivery device, the electronic module comprising at least one connector, wherein at least one connector is adapted to be connected to a port of the drug delivery device and wherein at least one connector is adapted to be connected to a port of a computer. Furthermore, the invention relates to a drug delivery device, comprising a port for connecting to the connector of the electronic module.

Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Abstract: The present invention provides a drug delivery device (1) comprising a drug delivery unit (10) comprising a dose expelling mechanism operable to expel a dose of drug from a drug reservoir (11), a cap (20) configured for dismountable mounting over a portion of the drug delivery unit (10), the cap (20) comprising a cavity (25, 26) for reception of the portion of the drug delivery unit (10), a seal (40) adapted to provide a sealing in an interface between the cap (20) and the drug delivery unit (10), a sensor system (30) configured to monitor internal pressure in the cavity (25, 26) and to register an event in response to sensing a change in the internal pressure which numerically exceeds a specified threshold level over a period of less than 5 seconds, and energy means (50) for powering the sensor system (30).

Abstract: An injector including a syringe arranged along a longitudinal axis, a removable cover for removable engagement with the syringe and a cover removal assembly including an outer portion which is engagable by a user and is movable axially in a cover disengagement direction along an axial travel path with respect to the longitudinal axis and an inner portion which includes at least one engagement portion which is engagable with the removable cover, whereby axial movement of the inner portion in the cover disengagement direction removes the removable cover from the syringe, at least one of the outer portion and the inner portion being configured such as to provide an axially floating lost motion engagement between the outer portion and the inner portion.

Abstract: A nebulizer system is disclosed, and comprises a first portion and a second portion configured for selectably receiving and electrically connecting to the first portion. The first portion includes a first housing for containing fluid, a vibratable mesh which seals a first outer opening of the first housing and configured to release fluid from the first housing through the first outer opening, first electrical conductors electrically connected to the vibratable mesh, a wick arranged such that vibration of the vibratable mesh causes release of fluid from the wick, and a biasing member compressing the wick against the vibratable mesh. The second portion includes a second housing having a second outer opening, second electrical conductors for contact with the first electrical conductors, and control electronics electrically connected to the second electrical conductors and configured to control the vibratable mesh to cause fluid release from the first housing through the outer openings.

Abstract: A dosage inhaler includes an active liquid container, which contains a liquid having an active ingredient dissolved therein, and an atomizer by which the liquid is transformed into an aerosol and can be introduced into an aerosol dome, in which there is a baffle plate and to which an inlet tube and an outlet tube are attached, and an electronic control. The atomizer can be intermittently operated by a user and the user command readout is visible to the user. The generation of the amount of aerosol inside, and below, the aerosol dome is able to be separated in time from its eventual inhalation by the user.

Abstract: A fluid dispenser device having a body (10), a reservoir (20), a dispenser head (100) and a dispenser member (30) mounted on the reservoir (20) by a fastener ring (60). The dispenser member (30) has a dispenser-member body (31) and a movable member (35) that moves axially while the dispenser member (30) is actuated. A lateral actuator system (40) is secured to the body (10) and includes an actuator element (41) that moves between a rest position and an actuated, the reservoir moving in the body during actuation. The body includes a sleeve (15) arranged with a gap around a portion of the reservoir, and a resilient member (425) co-operating with the reservoir to urge it into contact with a side of the sleeve (15). The sleeve of the body extends around a bottom portion (25) of the reservoir, and the resilient element co-operates with the reservoir outside the sleeve.

Abstract: The invention related to dry powders that contain a therapeutic agent. The dry powders have characteristics, e.g., they are processable and/or dense in therapeutic agent that provide advantages for formulating and delivering therapeutic agents to patients.

Abstract: The present disclosure relates to a dose indicator comprising, a chassis comprising a chassis frame and a displacement portion comprising a drive part to engage an indexable first display unit indexable about a first display axis, the indexable first display unit comprising a drive tooth to drive an indexable second display unit indexable about a second display axis, the second display axis being non-coaxial with the first display axis, the indexable second display unit comprising two or more second display unit indexing teeth, wherein the drive tooth and each of the second display unit indexing teeth comprise lips on their respective engagement surfaces, the drive tooth lip and second display unit indexing tooth lip each being adapted to engage at an engagement angle that produces a resultant force acting to pull the first display unit and second display unit together. The present disclosure further relates to an actuator for an inhaler, wherein the actuator comprises a dose indicator as described above.

Abstract: An aerosol-generating system is provided, including an aerosol-generating device including a heater element; an aerosol-generating article, including a medicament source and a volatile delivery enhancing compound source; and at least one resilient member provided in the aerosol-generating device or the aerosol-generating article and being resiliently biased against the heater element, wherein at least one of the medicament source and the volatile delivery enhancing compound source contacts the at least one resilient member, and the aerosol-generating system is configured to heat the medicament source and the volatile delivery enhancing compound source of the aerosol-generating article so that the medicament source has a higher temperature than that of the volatile delivery enhancing compound source.

Abstract: A compact single-nostril atomizer for the inhalation of active ingredients is presented. The atomizer has an elastic U-shaped housing, a first end of which can be introduced into the nostril and a second end of which is formed as a clamping element. In the first end of the housing a cavity for receiving a reservoir is disposed. A reservoir containing an active ingredient can be inserted into the cavity.

Abstract: A respiratory assistance component is disclosed that changes shape when an electrical charge is provided. The amount of electrical charge that is applied may be based on values, characteristics, or user controlled parameters of the respiratory assistance system. The component may be all or part of a patient interface, a tube, a flow generator, and/or a sleep mat.

Abstract: A positive exhalation pressure device (1) is described. The device (1) comprises a housing (2) having an annular chamber (5), a chamber inlet (6) configured to permit air into the chamber, a chamber outlet (7) configured to permit air out of the chamber, and a mouthpiece (8) in fluid communication with the chamber inlet. A movable body such as a ball (3) is disposed in the housing within the annular chamber and configured to revolve around the annular chamber in response to flow of air through the chamber from the chamber inlet to the chamber outlet. The movable body is configured to at least partially block the chamber outlet as it revolves around the annular chamber causing cyclical fluctuations in airflow resistance.

Abstract: A portable breathing machine includes a body case (100), wherein: a fan box (101), a cut-off device (108) and a control device (113) are arranged in the body case (100); a fan (8) is arranged in the fan box (101) through a fan noise reduction device (102); an air outlet of the fan box (101) is connected with an internal breathing tube (107); the cut-off device (108) is arranged on the internal breathing tube (107); an air outlet of the cut-off device (108) is connected with an external breathing tube (104) and a mask (105); the fan noise reduction device (102) includes a lower flexible cover (3) and an upper flexible cover (5); the lower and upper flexible covers cooperate to form an enclosed cavity for containing the fan (8). A working noise of the breathing machine is decreased to below 15 decibel.

Abstract: The present disclosure pertains to a pressure support system configured to provide pressure support therapy to a subject, wherein the pressure support system comprises a subject interface heater configured to controllably heat a pressurized flow of breathable gas to a target temperature that is offset from a baseline temperature. The breathable gas baseline temperature target offset ensures the gas delivered to the subject is delivered at a comfortable temperature and/or humidity level that does not cause airway dryness or result in condensed water in the subject interface. In one embodiment, the pressure support system comprises one or more of a pressure generator, a subject interface, a subject interface heater, one or more subject interface temperature sensors, one or more baseline temperature sensors, one or more general sensors, a humidifier, a user interface, a processor, electronic storage, and/or other components.

Abstract: This disclosure describes systems and methods for providing an optimized proportional assist breath type during ventilation of a patient. The disclosure describes a novel breath type that delivers a target airway pressure calculated based on a desired patient effort range to a triggering patient.

Abstract: A respiratory device for delivering gas to a patient comprises a gases passageway having proximal and distal ends, and a supplementary gas inlet in a side wall of the gases passageway. The supplementary gas inlet is adapted to direct gas along an interior surface of the gases passageway, such that the gas follows a generally helical path towards the distal end of the gases passageway.

Abstract: A cricothyrotomy apparatus includes a frame, a protuberance, and a blade member. The frame includes a blade guide. The protuberance extends in a first direction from the frame, and is located at a distance from the blade guide that corresponds to the distance between a sternal notch of an adult human and an anterior cricothyroid membrane of the adult human. The protuberance is sized and configured to be at least partly received by a sternal notch of an adult human. The blade member is slideably disposed in the blade guide.

Abstract: A system for controlling and monitoring flow in a cuffed endotracheal tube device is disclosed. The system comprises: a connector panel having at least three connectors adapted for establishing fluid communication with proximal ends of at least a first fluid line, a second fluid line and a cuff inflation line of the endotracheal tube device. The system can further comprise a processing unit and a control unit, wherein the processing unit is configured to instruct the control unit to execute various operations, including at least a rinsing procedure, a suctioning procedure, a cuff inflation procedure, a leak detection procedure and a venting procedure, and to select any of the first and the second fluid lines for any of the rinsing, suctioning, leak detection and venting procedures. In some embodiments, the system exploits the cuff as sensor to sense pulmonary data.

Abstract: A catheter guide structure is disclosed. Provided are a first guide module provided with an oxygen supply opening, a second guide module connected to the first guide module, and having an internal space that is opened only when the advancement of the catheter into the first guide module is necessary, and a third guide module connected to the second guide module to guide the advancement of the catheter into the first guide module. Accordingly, efficiency is ensured for the process of inserting a catheter in a respiratory system of a patient to suction foreign substances such as sputum present in the respiratory system of the patient assisted by the respirator and the process of removing the catheter such that nursing treatment for the patient can be provided with speed and efficiency. Further, according to the present disclosure, cleaning and sterilization inside and outside the catheter can be performed with ease.

Abstract: A cleaning device, system and method for use with an ETT or tracheostomy ventilation tube 60, a ventilator machine 900, a source(s) 602 of fluid (for example, pressurized or unpressurized) and a source(s) of suctioning 603 is disclosed. In some embodiments, the cleaning device is useful for cleaning an inner surface of the ventilation tube 60 and/or for preventing or hindering the accumulation of biofilm thereon. In some embodiments, it is possible to clean biofilm or any other material on the inner surface 201 by delivering fluid into an interior of the ventilation tube, wiping the tube interior with a width-expanded wiping element (e.g. an inflated balloon) by longitudinal motion of the wiping element, and suctioning material out of the ventilation tube ventilation tube.

Abstract: A cushion for a patient interface includes two or more bladders arranged in concentric relation. Each of the bladders includes a face-contacting portion adapted to engage the patient's face, and each of the bladders is adapted to be pressurized independently from one another. At least one of the bladders is an active bladder that is pressurized to at least a sealing pressure to form a continuous seal with the patient's face in use.

Abstract: A breathing arrangement includes a patient interface, at least one inlet conduit, and a headgear assembly. The patient interface includes a mouth covering assembly including a cushion structured to sealingly engage around exterior of a patient's mouth in use, a nozzle assembly including a pair of nozzles structured to sealingly engage within nasal passages of a patient's nose in use, and a flexible element connecting the mouth covering assembly and the nozzle assembly. The at least one inlet conduit is structured to deliver breathable gas into at least one of the mouth covering assembly and the nozzle assembly for breathing by the patient. The headgear assembly is removably connected to at least one of the mouth covering assembly and the nozzle assembly so as to maintain the mouth covering assembly and the nozzle assembly in a desired position on the patient's face.

Abstract: A patient interface and component parts which may include: a component such as a clip for supporting a gas supply tube to the interface; a buckle may be provided at an end of a headgear strap for releasable attachment to the interface; a manifold part of a patient interface may be attachable to the interface in a manner allowing for adjustment or re-orientation such that an associated gas supply conduit is re-routed to be to a left- or a right-side of the interface (or user); one or a pair of support side arms of the interface may be configured to be twisted or bent so as to more comfortably accommodate the shape of a user's face upon which they are to be located in use; parts of a manifold at the connection of a gas supply tube to the interface may be configured to be of a multi-part manifold assembly.

Abstract: A respiratory assistance device (1) for a patient, includes a tubular element forming a main channel (5) (207) which is to be connected via the distal end (7) thereof to an airway of the patient, the main channel connecting to the exterior of the respiratory system of the patient via the proximal end (6) thereof, the device further including at least one auxiliary channel (8) (209) allowing the injection of jets of breathable gas for ventilation of the patient via the distal outlet openings (17) of the auxiliary channel(s), the outlet openings opening out into the main channel in the vicinity of the distal end thereof, deflection elements (14b) (14a) allowing the deflection of gas jets to the interior of the main channel, and an internal jet separator, coaxial and central to the main channel, which further ensures diversion of the flow for expired gases.

Abstract: A device (102) provides respiratory treatment for SDB (including mild OSA) and other respiratory conditions. A flow generator warms and humidifies gas at controlled flow levels. For example, the device (102) delivers breathable gas to the upper airway at flow rates of about 10-35 Liters/minute. Levels of flow rate, temperature and/or humidification of the device may be automatically adjusted in response to the detection of SDB events. The device may also automatically deliver adjustments of any of the levels in accordance with detected phases of respiratory cycles. In some embodiments, the device automatically delivers distinct levels to either of the nares based on independent control of flow to each nare. A warm-up procedure controls temperature and humidity at a desired target during a ramp-up of flow to the set therapy level. A cool-down procedure controls temperature above the dewpoint to avoid condensation internal to the device and patient interface.

Abstract: Apparatus and methods for producing narrow-band radiation in the green region of the visible spectrum are described. The narrow-band radiation may be used to aid subjects experiencing photophobia. In some cases, subjects may experience a reduction in pain (e.g., migraine photophobia) when using the narrow-band radiation.

Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.

Abstract: An endoluminal device comprises a tubular member and a reinforcement member that is separable from, or together with, a wall of the tubular member, and removable in-situ.

Abstract: A guiding catheter has a proximal portion constructed of a tubular braid and a shape-retentive distal portion including a superelastic hypotube cut to define particular mating, support, shape-retentive and flexibility characteristics. A tubular liner extends through both of the tubular braid and the hypotube. The hypotube is joined to the braid using a mechanical interlock that has high torque transfer from the braid to the hypotube. A short portion of high stiffness polymer tube is provided at a joint between the braid and the hypotube. A polymeric outer jacket is provided over the proximal and distal portions, including the polymer tube. The jacket is heat set over the hypotube to remove residual stress.

Abstract: A catheter hub for use with a medical device and a catheter, the hub includes a hub body defining a fluid passageway in communication with a first aperture. Optionally, the hub body defines a second aperture that intersects the first aperture. The hub body attaches to the catheter wherein the fluid passageway and the catheter are aligned for fluid flow therethrough. The first aperture extends from and communicates with the fluid passageway to an exterior surface of the hub body and the first aperture configured to receive the medical device. The second aperture extends from and communicates with the first aperture and the exterior surface. A sealing element is sized for and positioned in either the first or the second apertures. The sealing element is configured to receive the medical device and seal both of the first and the second apertures.

Abstract: A medical kit, including a split-tip catheter, a first intra-catheter stiffener element, a second intra-catheter stiffener element, a first guidewire, and a second guidewire. The split-tip catheter includes a first lumen in fluid communication with a first distal opening and a second lumen in fluid communication with a second distal opening with the first distal opening proximal to the second distal opening. The first intra-catheter stiffener element is designed for disposition in the first lumen, and the second intra-catheter stiffener element is designed for disposition in the second lumen. The first intra-catheter stiffener element includes a first guidewire lumen, and the second intra-catheter stiffener element includes a second guidewire lumen.

Abstract: A control system and method are provided for control of a steerable catheter, the catheter including at least two control wires, a distal end of each of the control wires being coupled to the catheter at a distal region thereof, the control system comprising: a housing coupled to the catheter; a slide assembly positioned within the housing and operable to translate linearly therein; a proximal portion of each of the at least two control wires being positioned through the slide assembly; and a control knob rotatably coupled to the housing for linearly translating the slide assembly, thereby enabling the slide assembly to separately manipulate each of said at least two control wires to effect a change in a deflection of said catheter.

Abstract: A modular handle assembly for supporting and controlling a steerable catheter having at least one deflection wire includes a handle portion which extends along an axis for being secured about a portion of the steerable catheter. The modular handle assembly includes at least one barrel that is rotatably connected to the handle portion for rotation about said axis and at least one actuation screw shaft that is disposed within said handle portion and which extends through the barrel for connection with the deflection wire of the steerable catheter. At least one pinion gear is disposed radially between the actuation screw shaft and the barrel and is threadedly interconnected with the actuation screw shaft and the barrel for translating rotational movement of the barrel about the axis into axial movement of the actuation screw shaft to provide for movement of the deflection wire to curl the steerable catheter.

Abstract: A steerable surgical device includes a flexible joint positioned between first and second tubular elements, with multiple shape memory alloy wire elements extending across or through the joint being circumferentially spaced relative to one another and independently actuatable to effectuate pivotal movement between the first and second tubular elements (e.g., along at least two or at least three nonparallel planes) to provide enhanced maneuverability relative to single degree of freedom steerable devices. Longitudinal guide structures (e.g., channels or bores) and/or anchor points for shape memory alloy wire elements may be circumferentially spaced in or on the tubular elements to receive the shape memory alloy wire elements.

Abstract: Articulation devices, systems, and methods for articulating elongate flexible structures can locally contract a flexible elongate frame or skeleton of an elongate flexible body such as a catheter. Balloons along one side of an axial segment of the elongate flexible body can be inflated so as to help define a resting shape of the elongate body. The skeleton may have pairs of corresponding axially oriented surface regions coupled to each other by a loop of a deformable helical coil structure. Balloons may be between the regions, and the pairs may be separated by an offset that increases when the axis of the skeleton is axially compressed. Inflation of the balloons can axially contract or shorten the skeleton adjacent the balloons so that the elongate body bends toward the balloons.

Abstract: An insertion assembly and method of manufacturing an insertion assembly. The method includes forming a catheter assembly including a catheter hub and a catheter, inserting a needle into the catheter assembly such that a distal tip of the needle extends distal of a distal end of the catheter, and permanently adhering an interface pad to the catheter hub. The interface pad can include a foam material including a haemostatic agent. The haemostatic agent can include microdispersed oxidized cellulose. The foam material can further include an antimicrobial agent such as chlorhexidine gluconate.

Abstract: Catheter adapters and vascular access device including catheter adapters are discloses. The catheter adapter tip opening has an internal curvature defining a tapered region in the lower portion, but not the upper portion, to support a flexured portion of the catheter to prevent kinking and occlusion.

Abstract: The invention relates to a puncturing system comprising an outer tubular body which is designed to remain in a body part of a living being, characterized in that the puncturing system has at least one inner tubular body and a puncturing needle, wherein the inner tubular body is guided through a working lumen of the outer tubular body and can be longitudinally displaced with respect to the outer tubular body, and the puncturing needle is guided through a puncture lumen of the inner tubular body and the inner tubular body can be longitudinally displaced with respect to the puncturing needle, wherein, after a body part has been punctured by means of a puncturing section of the puncturing needle, which protrudes out of a patient-side end of the puncturing system, the inner tubular body can be moved out of the patient-side end of the catheter at least partially out of the outer tubular body, and is thereby designed to accommodate the puncturing section of the puncturing needle, which protrudes out of the patient-s

Abstract: A handheld vascular access device for gaining access to a patient's vessel includes a hub, a plurality of access needles and a manifold. The hub has an inner wall and side walls that define a plurality of ports. Each of the plurality of ports has a proximal port end and a distal port end. The proximal port ends define a proximal cross-sectional area and the distal port ends define a distal cross-sectional area. The proximal cross-sectional areas are greater than the distal cross-sectional areas. Each of the plurality of ports taper from the proximal port end to the distal port end. The plurality of hollow access needles is arranged along a plane and fixedly coupled to the distal end of the hub. Each of the plurality of needles has a tip. The manifold removably engages the hub at the proximal end of the hub.

Abstract: Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

Abstract: Devices and methods for providing an elastically deforming guidewire tip, capable of withstanding the extreme forces of high-speed rotational atherectomy, in particular orbital motion induced by an eccentric abrasive head, are disclosed. In certain embodiments, the reformable tip comprises an inner nitinol support coil, wherein the reformable tip may be attached to a larger proximal core for improved kink resistance and support for delivering adjunctive devices. In other embodiments, an inner nitinol support coil may be wrapped with a braided coil and/or a polymer sleeve. The resulting tip is more flexible with reduced risk of perforation than known guidewire tips.

Abstract: A catheter insertion device with a housing and an interior space. An access needle and a guide wire supported by and moveable relative to the access needle. A restraining element attached to a handle to limit the motion of the guide wire relative to the access needle. A catheter insertion device with a housing and an interior space. An access needle and a guide wire channel attached to the access needle. A guide wire supported by the guide wire channel. A handle attached to the guide wire to move the guide wire relative to the guide wire support channel. A method of introducing a catheter into a vessel by inserting a guide wire substantially contained within a housing into a vessel. Next, advance a catheter over the guide wire and into the vessel. Next, withdraw the guide wire out of the vessel and completely into the housing.