With Gas Flow Control Means Other Than Pivotal Or Removable Closure Patents (Class 128/203.24)
  • Patent number: 10213574
    Abstract: The present invention provides a new inhaler device for the storage and administration of inhalable liquids to a patient, such as halogenated volatile liquids, particularly methoxyflurane for use as an analgesic, the device having one or more advantages or improvements over known inhalers.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 26, 2019
    Inventors: Greg Rowland, Edward Linacre, Glenn Gilbert, Viktor Legin
  • Patent number: 9919115
    Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: March 20, 2018
    Assignee: Manta Devices, LLC
    Inventors: Andrew Jones, Richard L. Miller
  • Patent number: 8833365
    Abstract: A dosing device generating a gas flow with an active substance finely dispersed, with a first gas flow channel and with a dosing chamber that can be fitted in the area of the first gas flow channel, and a dosing chamber release mechanism with a separating element. The first gas flow channel and/or a connection between the first gas flow channel and the dosing chamber is blocked when the separating element is in a closed position. The first gas flow channel and/or the connection between the first gas flow channel and the dosing chamber is freed when the separating element is in an open position. A slide guide element can be driven by the under-pressure applied to the mouthpiece. The separating element and/or the slide guide element is provided with a slide element that influences the sliding friction properties.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: September 16, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Stefan Mayer, Yorick Kamlag
  • Patent number: 8794232
    Abstract: A monodose inhaler for powdered medicaments consists of a hollow substantially pipe-shaped body that has a first portion (H), for housing a capsule or cartridge of powdered medicament, defined by a wall (W) in which there are formed slots (S) as air intakes to an inner region where the powder drops, and a second portion (M) connected to the first portion (H) for delivering the medicament by means of a primary stream (F) that carries the powder from the drop region along a delivery duct (D) whose end is suitable to be placed in the patient's mouth, and it further includes a secondary duct (D?) located under the delivery duct (D) and provided with its own air intake (S?) for delivering a powderless secondary stream (F?).
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: August 5, 2014
    Inventors: Giampiero Cossi, Mario La Barbera, Marco Cecchini
  • Patent number: 8511303
    Abstract: An exhalation breath-actuated nasal deliver device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; and delivery unit, as one of a mechanical delivery pump or a nebulizer, for delivering a substance to the nosepiece; and an actuation mechanism for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: August 20, 2013
    Assignee: Optinose AS
    Inventor: Per Gisle Djupesland
  • Patent number: 8413650
    Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: April 9, 2013
    Assignee: Canon Kabushiki Kaisha
    Inventors: Sachiko Inoue, Hideki Kaneko, Masaru Sugita
  • Patent number: 8245705
    Abstract: The invention provides an inhaler for dispensing medicament. The inhaler comprises auxiliary energy provision means for providing auxiliary energy for aerosolizing medicament; energy release means for releasing auxiliary energy from the auxiliary energy provision means; feed means for feeding a dose of medicament, characterized in that the inhaler comprises control means for controlling a time interval between aerosolization of the medicament and a user's inhalation. The inhaler is operable, in use, to aerosolize medicament using the auxiliary energy, and harness the user's inhalation to deliver the aerosolized medicament to the user.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: August 21, 2012
    Inventor: Jianhe Li
  • Patent number: 8196578
    Abstract: Disclosed is an inhaler for administering a medicament in the form of inhalable substances, substance formulations, or substance mixtures, especially in the form of a powder as depicted in exemplary FIG. 1. Said inhaler comprises a housing (1) which is provided with an interior (18) for accommodating at least one capsule that is filled with the medicament. The housing (1) is coupled to a mouthpiece (5) while an actuator (12) encompassing at least one needle (13) is mounted so as to be movable towards the housing in order to open the capsule. The mouthpiece (5) is effectively connected to the actuator (12) in such a way that the needle (13) of the actuator (12) does not extend into the interior (18) for puncturing the capsule in an operational position of the mouthpiece (5).
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: June 12, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Oliver Wendland
  • Patent number: 8181646
    Abstract: An aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into a first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter, thereby creating a closed system that is therefore capable of delivering a fixed concentration of the medication to the patient due to a valve of the valve mechanism being closed when the patient inhales and the medication is delivered to the patient.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 22, 2012
    Assignee: Aeon Research and Technology, Inc.
    Inventors: Sunil Kumar Dhuper, Herbert Fred D'Alo
  • Patent number: 8146592
    Abstract: Fluid flow regulators and fluid conservers are disclosed. An exemplary fluid conserver may be operated in one of an intermittent mode of operation and a continuous mode of operation. Further, the exemplary conserver provides at least two pulses of fluid in response to a first trigger, such as the inhalation of a patient.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: April 3, 2012
    Assignee: Ameriflo, Inc.
    Inventors: James A. Voege, David A. Ferrer, Matthew G. Thie
  • Patent number: 8066002
    Abstract: There is provided a manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit. The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber outlet. The manifold is arranged such as to delay the emptying of the medicament powder from the blister pocket.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: November 29, 2011
    Assignee: Glaxo Group Limited
    Inventors: David Prime, Richard Ian Walker
  • Patent number: 8061350
    Abstract: A process and a device for dosing a pharmaceutical agent, preferably a liquid, are proposed. To achieve an enhanced dosing accuracy, a first component that is produced in batches, such as a shaped seal, is combined with a second component, such as a guide pipe selected from a suitable group guide pipes, wherein the suitable group of second components is selected based on at least one decisively significant value of the respective batch first components and is distinguished by an essential value of the second component which will optimize the sealing between the first and second components.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: November 22, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Georg Boeck, Johannes Geser, Matthias Hausmann, Hans-Juergen Koelbel, Joachim Eicher, Christian Feiertag
  • Patent number: 8028695
    Abstract: A sound dampening apparatus to be disposed in pneumatic connection with a respiratory support system. The respiratory support system may comprise a source of medical gas, a plurality of pneumatic connections and a patient interface. The sound dampening apparatus comprises an inlet, an outlet, and an outer case which forms a sound dampening chamber. As the medical gas flows through the sound dampening apparatus, the noise energy associated with the flow of medical gas is reduced.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: October 4, 2011
    Assignee: The General Electric Company
    Inventors: Jaron M. Acker, Kristopher J. Bilek, John R. Pinkert, Robert Q. Tham
  • Patent number: 8025050
    Abstract: A nebulizer and cartridge structure thereof for use in a nebulization apparatus comprises a first cartridge accommodation space and a second cartridge accommodation space. The first cartridge accommodation space includes at least one connection bottom, and the second cartridge accommodation space includes at least one connection side. Moreover, the second cartridge accommodation space is disposed under a lower connection position of the first cartridge accommodation space. The connection bottom is connected to the connection side to form an included angle that can be a lead angle. The lead angle further includes a fillet angle or a chamfering angle. Accordingly, the nebulizer and the cartridge structure can efficiently reduce the residues of liquid medicament.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: September 27, 2011
    Assignee: Health & Life Co., Ltd.
    Inventors: Shan-Yi Yu, Han-Chang Liu
  • Patent number: 7975690
    Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: July 12, 2011
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Patent number: 7913688
    Abstract: A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 ?m. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: March 29, 2011
    Assignee: Alexza Pharmaceuticals, Inc.
    Inventors: Stephen Cross, Craig C. Hodges, Ron L. Hale, Peter M. Lloyd, Daniel J. Myers, Reynaldo J. Quintana, Joshua D. Rabinowitz, Curtis Tom, Martin J. Wensley
  • Patent number: 7861713
    Abstract: According to one aspect of the present invention, an aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into a first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter, thereby creating a closed system that is therefore capable of delivering a fixed concentration of the medication to the patient due to a valve of the valve mechanism being closed when the patient inhales and the medication is delivered to the patient.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: January 4, 2011
    Inventors: Sunil Kumar Dhuper, Herbert Fred D'Alo
  • Patent number: 7849853
    Abstract: A ventilator circuit for use in administering medication to a patient includes a chamber housing defining an interior space and having an input end and an output end and a one-way inhalation valve positioned upstream of the interior space. The one-way inhalation valve is operative to permit a flow of medication into the interior space of the chamber housing. An inhalation conduit communicates with the output end of the chamber and is adapted to transmit the medication to the patient. An exhaust conduit is connected to the inhalation conduit and a one-way exhaust valve is located in the exhaust conduit. The one-way exhaust valve is adapted to prevent a backflow of gas from the exhaust conduit into the inhalation conduit. A method of administering a medication to a patient is also provided.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: December 14, 2010
    Assignee: Trudell Medical International
    Inventors: Jerry R. Grychowski, Martin P. Foley, Michael S. Dunn
  • Patent number: 7802570
    Abstract: A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: September 28, 2010
    Assignee: Breathe Pharmaceuticals
    Inventor: Mark B. Mecikalski
  • Patent number: 7708011
    Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: May 4, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH and Co. KG
    Inventors: Dieter Hochrainer, Joerg Schiewe, Bernd Zierenberg, Stephen Dunne
  • Patent number: 7617822
    Abstract: A breath actuated dry powder inhaler, comprising a substantially disc shaped air circulation chamber for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially circular or polygonal sidewall extending about a central axis between top and bottom walls of the chamber so that the height of the chamber is smaller than its diameter. A plurality of air supply channels disposed about the circumference of the chamber, which channels extend from joint or separate air inlets and which channels enter the chamber substantially tangentially to its sidewall. At least one of the supply channels extends through a powder dose supply region of the inhaler. The chamber further comprises an air outlet axially extending from a discharge opening in the centre of the top or bottom wall of the chamber and connects to a discharge channel that extends to a mouthpiece.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: November 17, 2009
    Assignee: Rijksuniversiteit Groningen
    Inventors: Anne Haaije De Boer, Paul Hagedoorn, Henderik Willem Frijlink
  • Patent number: 7556037
    Abstract: An inhalation aid to be used in connection with an aerosol dispenser. The inhalation aid includes a chamber designed with an opening for connection to an aerosol dispenser and an opening including a mouthpiece for drawing the aerosol. The chamber is designed with a variable volume. The chamber is delimited by a conically tapering expansion bellows made of a continuous, elastic material, whereby a simple and tight construction of the inhalation aid is obtainable.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: July 7, 2009
    Inventor: Christoph Klein
  • Patent number: 7533669
    Abstract: A gas delivery system and a method of delivering gas are disclosed. In one such system there is a housing and a displaceable partition. The housing may be divided by the partition into a respirator side and a patient side. The partition may have one or more holes extending through the partition to allow gas to move from one side of the partition to the other side of the partition.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: May 19, 2009
    Assignee: The Research Foundation of State University of New York
    Inventors: Bradley P. Fuhrman, Mark S. Dowhy
  • Publication number: 20080041375
    Abstract: The present invention relates to a personal use assistive breathing device wherein a can adaptor or bottle mounting member is secured to a bottle canister containing a pressurized gas. A mouth piece member retains an action knob positioned for actuating a stem valve on the bottle canister upon a rotation. During use the action knob is spaced away from the mouthpiece and air passages entrain ambient atmospheric air with the escaping pressurized gas. The action knob may be retained in the in-use position without continual pressure allowing hands-free use. During storage, the action knob is spaced in contact with the mouthpiece prohibiting unintended gas release and enabling ready handling without risk of gas-loss.
    Type: Application
    Filed: August 21, 2006
    Publication date: February 21, 2008
    Inventor: Kelsey Stratton
  • Publication number: 20070283954
    Abstract: According to one aspect of the present invention, an aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system includes a first holding chamber for holding the aerosol particles prior to deliver to the first conduit member and a valve mechanism associated with the first conduit member. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into the first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 13, 2007
    Inventors: Sunil Kumar Dhuper, Herbert Fred D'Alo
  • Patent number: 7267121
    Abstract: A pressure-assisted breathing system is provided that comprises: a pressure-generating circuit for maintaining a positive pressure within the system; a patient interface device coupled to a patient's respiratory system; a respiratory circuit for providing gas communication between the pressure-generating circuit and the patient interface device; means for introducing aerosol particles into the gas flow in the respiratory circuit; and means for discontinuing the introduction of aerosol particles into said respiratory circuit gas flow when the patient exhales. In one embodiment, a flow sensor is disposed in an auxiliary circuit in fluid communication with the respiratory circuit and electronically coupled with a nebulizer. The flow sensor is adapted to detect changes in the volumetric flow rate of gas in the auxiliary circuit when the patient exhales and stops exhaling and sends corresponding electronic signals to the nebulizer to turn off and turn on, respectively.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: September 11, 2007
    Assignee: Aerogen, Inc.
    Inventor: Ehud Ivri
  • Patent number: 7228859
    Abstract: An improved humidifier assembly includes a tubing and a one-way valve for equalizing pressure between gas space of a water supply container and gas space of a humidifier vessel.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: June 12, 2007
    Assignee: Teleflex Medical Incorporated
    Inventor: Thomas C. Loescher
  • Patent number: 7165546
    Abstract: A self-contained system which converts nitrous oxide to a breathable gas mixture of nitrogen and oxygen. In the preferred embodiment of the present invention, a portable system is disclosed wherein liquefied nitrous oxide is converted to a breathable gas mixture of nitrogen and oxygen. The decomposition occurs over a catalyst bed which is all contained in a small reactor. The invention is useful for underwater, fire fighting and outer space applications.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: January 23, 2007
    Assignee: Pioneer Astronautics
    Inventors: Brian M. Frankie, Robert M. Zubrin, Scott E. Lowther
  • Patent number: 7029656
    Abstract: Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: April 18, 2006
    Inventor: Robert E. Coifman
  • Patent number: 6997184
    Abstract: A cool air inhaler for use in treating croup, having a body having at least one side wall and a bottom wall forming an enclosed space open at an upper portion of the body wherein the upper portion of the body is adapted to generally conform to contours of a lower part of a patient face. An air chamber is formed in an upper part of the body and has an exhaust vent for exhausting the patient's exhaled air to an exterior space while an ice reservoir is formed in a lower part of the body to contain ice and meltwater from the ice and an air passage is connected from the exterior space and passing through the ice reservoir to conduct air to the air chamber.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: February 14, 2006
    Inventor: Timothy J. Donohue
  • Patent number: 6983747
    Abstract: The invention relates to an aerosol generator that comprises an oscillating membrane that is provided with openings. The aerosol generator is further characterized in that the liquid container is impinged upon with negative pressure by displacing a sealing element using a slidable sleeve and a rotary sleeve.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: January 10, 2006
    Assignee: Pari GmbH Spezialisten für Effektive Inhalation
    Inventors: Thomas Gallem, Markus Urich
  • Patent number: 6823862
    Abstract: A flow indicator (F) for an inhaler (I) comprises a housing (1) defining a mouthpiece (M2), an inlet (2) for connection to the product-dispensing chamber of the inhaler, a chamber (3) positioned between the inlet and the mouthpiece of the indicator, and an indicator member (4) movably mounted in the chamber in such a manner that inhalation at the mouthpiece of the indicator causes the indicator member to move within the chamber. The indicator member (4) is so mounted as to co-operate with a switch member (6, 9) associated with the housing (1) to provide an indication when inhalation is at an optimum rate for a given inhaler attached to the inlet (2).
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: November 30, 2004
    Assignee: Fyne Dynamics Ltd
    Inventor: John Peter McNaughton
  • Publication number: 20040134487
    Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.
    Type: Application
    Filed: November 6, 2003
    Publication date: July 15, 2004
    Inventors: Mark E. Deem, Bernard H. Andreas, Sunmi Chew, Antony J. Fields, Ronald French, Hanson S. Gifford, Ronald R. Hundertmark, Alan R. Rapacki, Douglas S. Sutton, Peter M. Wilson
  • Patent number: 6725860
    Abstract: A monitoring process for the reliable metering of different gaseous anesthetics uses a gaseous anesthetic monitor designed as only a single-channel monitor for determining the concentration of only one gaseous anesthetic. The process also uses an associated gaseous anesthetic metering means.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: April 27, 2004
    Assignee: Dräger Medizintechnik GmbH
    Inventors: Carl F. Wallroth, Frank Gottschalk, Ernst-Günter Scharmer, Helmut Thiemann
  • Patent number: 6694978
    Abstract: A patient ventilator system has a high-frequency oscillation ventilator connectable to a patient circuit and operable to induce oscillations within gas in the circuit at a predetermined high-frequency and a gas supply connectable to the patient circuit for supplying breathing gas thereto. A detection device is also included within the ventilator system and is adapted to monitor during the operation of the high-frequency oscillator ventilator, gas pressure and/or gas flow to detect a variation therein not derived from the induced high-frequency oscillations and to output a trigger signal dependent on the detected variation indicating a spontaneous breathing effort. The gas supply is operable on receipt of the trigger signal to supply breathing gas into the circuit at a level to assist the spontaneous breathing effort.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: February 24, 2004
    Assignee: Siemens-Elema AB
    Inventor: Johan Bennarsten
  • Patent number: 6681762
    Abstract: A device for flow rate limitation at low differential pressures, particularly for limiting the volumetric inhalation flow during inhalation of therapeutic aerosols, consists of a housing 11 including an aspiration orifice 14, an inhalation orifice 15 and a flow passage 23 disposed therebetween. The flow passage has a flat elongate cross-section with flexible large-area walls 18, 20 having a cross-sectional area adapted to be reduced, as a function of the differential pressure prevailing between the inhalation orifice and the aspiration orifice, as well as of the flexibility of the material of the walls, to a size appropriate for a predetermined volumetric maximum inhalation flow.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: January 27, 2004
    Assignee: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Gerhard Scheuch, Knut Sommerer, Bernhard Müllinger, Friedel Haas, Sascha Roeder
  • Patent number: 6595209
    Abstract: A dry powder delivery system and method for use, the system having an elongated tube containing a matrix having a measured amount of dry particles of a therapeutic compound and a porous element having a desiccant therein. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: July 22, 2003
    Inventors: Jed E. Rose, Frederique Behm, James Turner
  • Patent number: 6584971
    Abstract: A nebulizer has structure for determining the duration of a pulse of atomization during inspiration, the determination structure including components for measuring the tidal volume of a patient, measuring the duration of inspiration, for storing estimates of the volume of a patient's upper airway, and for calculating the duration of the pulse. The duration of the pulse is calculated on the basis of the tidal volume, the duration of inspiration, and the stored estimated volume of patient's upper airway.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: July 1, 2003
    Assignee: Medic-Aid Limited
    Inventors: Jonathan Stanley Harold Denyer, Anthony Dyche, Ivan Richard Prince
  • Patent number: 6526969
    Abstract: An inhaler device and a method in which powder for inhalation is jetted off a prepared device surface containing a defined pre-metered quantity of finely divided powder. The jetting function is obtained by a directed air stream pushing or cutting free a medical powder applied to a carrier surface and by creating a stream of air dispersing the powder into inspiratory air at the moment it is being inhaled. The inhaler device includes active (air permeable) porous walls for preventing finely divided powder from sticking to the inner faces of the inhaler device by creating a pressure gradient across the active wall, thus forcing a small flow of air through the active wall thereby keeping the powder from sticking to the inner faces.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: March 4, 2003
    Assignee: Microdrug AG
    Inventors: Lars-Gunnar Nilsson, Thomas Nilsson
  • Patent number: 6435176
    Abstract: The present invention relates to a spacer for children primarily intended to be used in conjunction with a metered dose inhaler (MDI), said spacer having a generally oblong shape and being rotationally symmetrical around a central, longitudinal axis and being provided with an opening at each end located centrally in said axis for connection of an meterd dose inhaler respectively of a mouth-piece or similar. The spacer has a small total volume which is in the range between 50 and 400 ml, and the material in the spacer has a surface resitivity which is lower than 109 Ohm, preferably lower than 106 Ohm.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: August 20, 2002
    Assignee: Astra Aktiebolag
    Inventors: Elna Birgitta Berg, Hans Jörgen Nilsson
  • Patent number: 6347627
    Abstract: A self-contained system which converts nitrous oxide to a breathable gas mixture of nitrogen and oxygen. In the preferred embodiment of the present invention, a portable system is disclosed wherein liquefied nitrous oxide is converted to a breathable gas mixture of nitrogen and oxygen. The decomposition occurs over a catalyst bed which is all contained in a small reactor. The invention is useful for underwater, fire fighting and outer space applications.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: February 19, 2002
    Assignee: Pioneer Inventions, Inc.
    Inventors: Brian M. Frankie, Robert M. Zubrin, Scott E. Lowther
  • Patent number: 6341605
    Abstract: An inhalant medicator comprises a medicator body formed at one axial end with a capsule housing hole and at another axial end with an inhalant port, an inflow air passageway having an axial inflow passage extending in an axial direction of the medicator body and a first pin insertion hole extending in a radial direction of the medicator body for communicating the capsule housing hole with the atmosphere, an outflow air passageway having an outflow passage extending in the axial direction of the medicator body and a second pin insertion hole extending in the radial direction of the medicator body for communicating the capsule housing hole with the inhalant port, and a boring tool having pins insertable toward a capsule through the first and second insertion holes for pricking holes in the capsule accommodated in the capsule housing hole with the pins.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: January 29, 2002
    Assignees: Unisia Jecs Corporation, Dott Limited Co.
    Inventors: Hisatomo Ohki, Shigemi Nakamura, Kazunori Ishizeki, Yoshiyuki Yazawa, Akira Yanagawa
  • Patent number: 6298845
    Abstract: A vaporizer for vaporizing a liquid anaesthetic has an inlet for a carrier gas, an outlet for the carrier gas and vaporized anaesthetic, a flow channel connecting the inlet to the outlet, a chamber for liquid anaesthetic, a first connection between the flow channel and the chamber, a second connection between the flow channel and the chamber downstream from the first connection and a throttle in the flow channel between the first connection and the second connection. The second connection has a conduit, one end of which is immersed in the liquid anaesthetic, and a valve connected to the other end of the conduit so as to increase safety, prevent leakage and erroneous dispensing and allow the use of liquid anaesthetics with a low boiling point. The valve is devised to open when there is a predetermined drop in pressure across the throttle, allowing liquid anaesthetic to be dispensed into the flow channel.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: October 9, 2001
    Assignee: Siemens Elema AB
    Inventors: Kasper Höglund, Pär Emtell
  • Patent number: 6189531
    Abstract: An adjustable gas flow regulator device primarily for use in medical care, said device comprising a two-part body (8/25) having a high pressure gas inlet connector (1) and a gas outlet connector (16) mounted thereon. Mounted within the body is a conventional regulator comprising a piston (9) axially movable in a stepped bore (46/47). Mounted between the output of the regulator and the outer connector (16) is a flow selector device comprising a flow selecting member (13) rotatable by means of a knob (31). The flow selecting member (13) is formed with a plurality of radially extending bores (54) in the outer part of each of which is fitted a setting plug which may be externally adjustable by a tool (not shown).
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: February 20, 2001
    Assignee: Protector Technologies BV
    Inventor: Andrew Richard Thomas Tatarek