Abstract: The invention relates to a method for automatically determining, on a bone comprising a head portion contiguous to a neck portion, parameters for characterizing a bump deformation on the head-neck junction of the bone from acquired 3D medical image, the method comprising the following steps: i) constructing a 3D surface model of the bone; ii) fitting a sphere on the spherical portion of the head of the bone; iii) determining a neck axis characterizing the neck portion of the bone; iv) determining from the fitted sphere and the neck axis, a clock face referential on the head of the bone rotating around the neck axis; v) determining a 3D curve on the 3D surface model characterizing the head-neck junction of the bone; vi) determining, from the 3D curve, the summit of the bump deformation of the head-neck junction of the bone; vii) determining, from said summit of the bump deformation, first and a second parameters (?3D, iMax) characterizing the maximum bump deformation of the head-neck junction of the bone.

Abstract: A method for evaluating dosing from an implanted infusion system that includes receiving input regarding the identity of a therapeutic agent into an external device. The method further includes displaying on the external device a predetermined set of symptoms associated with the therapeutic agent; receiving input into the external device regarding with which of the symptoms the patient presents; and determining whether the therapeutic agent is being delivered, or has been delivered, at an appropriate dose based on the input identity of the therapeutic agent and the input symptoms.

Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

Abstract: A three-dimensional position and orientation tracking system comprises one or more pattern tags, each comprising a plurality of contrasting portions, a tracker for obtaining image information about the pattern tags, a database with geometric information describing patterns on pattern tags; and a controller for receiving and processing the image information from the tracker, accessing the database to retrieve geometric information, and comparing the image information with the geometric information. The contrasting portions are arranged in a rotationally asymmetric pattern and at least one of the contrasting portions on a pattern tag has a perimeter that has a mathematically describable curved section. The perimeter of the contrasting portion may comprise a conic section, including for example an ellipse or a circle. The tracking system can be implemented in a surgical monitoring system in which the pattern tags are attached to tracking markers or are themselves tracking markers.

Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.

Abstract: A system and method for automated diagnosis of atrial fibrillation through remote monitoring is described. Physiological measures including data either recorded on a regular basis by a medical device or derived therefrom are stored. Physiological measures recorded during a baseline period are identified. Physiological measures including cardiac rhythm and changes to the cardiac rhythm originating subsequent to the baseline period are identified. Cardiac rhythm changes for palpitations are evaluated and a time course for the cardiac rhythm changes upon an indication of palpitations is determined. A patient status including an onset of atrial fibrillation conditioned on the time course comprising a short duration is formed.

Abstract: The invention relates to a method for positionally correlating, with computer assistance, patient image information included in image data generated by a magnetic resonance scanner and fiducial patient markers represented in the image data, wherein a positional relationship between the patient image information and the fiducial markers is determined by taking into consideration at least the following parameters: a) the material properties of the fiducial markers; b) image generation data included in the image data or provided with the image data; c) the resonance frequency recording mode of the magnetic resonance scanner; and d) any relative positional shift between the patient data and the fiducial markers resulting from the combination of the parameters a) to c). The invention also relates to the use of such a positional correlation in a method for registering patient image data and in a method for navigationally assisting a medical procedure.

Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.

Abstract: A system for monitoring a dermatologic condition is provided. The system may include a processor configured to receive an image depicting a dermatologic condition and a swatch adjacent to the dermatologic condition, normalize the image to receive a normalized image, and detect one or more parameters associated with the dermatologic condition based on the normalized image. The system may then perform a search of previously taken images of the same dermatologic condition, compare them with a newly taken image, and advise a user whether any changes were detected.

Abstract: A robot-guided system to assist orthopaedic surgeons in performing orthopaedic surgical procedures on pre-positioned inserts, including for the fixation of bone fractures, and especially for use in long bone distal intramedullary locking procedures. The system provides a mechanical guide for drilling the holes for distal screws in intramedullary nailing surgery. The drill guide is automatically positioned by the robot relative to the distal locking nail holes, using data derived from only a small number of X-ray fluoroscopic images. The system allows the performance of the locking procedure without trial and error, thus enabling the procedure to be successfully performed by less experienced surgeons, reduces exposure of patient and operating room personnel to radiation, shortens the intra-operative time, and thus reduces post-operative complications.

Abstract: A method and system to evaluate image-guided dental implant treatment plans with error simulation. Error sources contributing to the inaccuracy of implant cases come from impressions, stone models, radiographic guides, CT scan and its image processing, surgical guides, as well as the surgical procedures. They are translated into the deviations between the planned and actual implant positions and orientations. The error simulation is to continuously modify and update treatment plans with the possible deviations so that the treatment plans can be visually evaluated along with other evaluation tools.

Abstract: Some embodiments of the present invention include a digital scale to measure a weight of a user who stands on the digital scale; and to calculate and convey to the user a dosage of a medicament which is appropriate for the user based on the measured user weight. The digital scale may determine the medicament dosage by performing a local query to a locally-stored medicament database which may be stored locally within the digital scale, and/or by performing a remote query to a remotely-stored medicament database which may be stored externally to the digital scale.

Abstract: A method for reading an emulsion (3) including droplets and a continuous phase surrounding the droplets, the method includes: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) based on the scanning. Preferably, the droplets do not move during scanning, for example by solidifying the continuous phase or by using a two-dimensional compact or semi-compact network of droplets. The method can further include time-based monitoring of a chemical or biological reaction taking place in at least one of the droplets. A device implementing this method is also described. The method is applicable for the detection and/or sorting of microdroplets performing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.

Abstract: Determining a shape of a medical device to be implanted into a subject produces an image including a defective portion and a non-defective portion of a surface of a tissue of interest included in the subject. The tissue of interest is segmented within the image. A template, representing a normative shape of an external anatomical surface of the tissue of interest, is superimposed to span the defective portion. An external shape of an implant, is determined as a function of respective shapes of the defective portion as seen in the template, for repairing the defective portion.

Abstract: An implantable medical device system and method provide physiological variable monitoring for use in patient management. A target value for a physiological variable and formulations for computing metrics of the physiological variable are stored. Values of the physiological variable are determined from a sensed physiological signal and are used to compute a selected metric. The metric is compared to the stored target value.

Abstract: A method for performing a patient oxygenation test using one or more computing devices is provided. The patient oxygenation test comprises a plurality of instructions for implementing a workflow for determining an oxygenation status for a patient. An entry or selection is received of one or more physiological parameters for the patient to be monitored during the patient oxygenation test. An entry or selection is received of one or more thresholds for at least one of the physiological parameters to be monitored during the patient oxygenation test. A determination is made as to whether any of the physiological parameters exceed limits set by the one or more thresholds. One or more actions are taken when one or more of the physiological parameters exceed the limits set by the one or more thresholds. A summary and analysis are provided of the test results.

Abstract: Various embodiments may provide methods and systems capable of evaluating physiological parameter data. The methods and systems may include a receiver capable of collecting a signal representative of a physiological status of a patient, a plurality of data analysis components, wherein each of the plurality of data analysis components is capable of generating a metric based on the signal, and an arbitrator communicatively coupled to each of the plurality of data analysis components and capable of generating a single metric from the metrics generated by the plurality of data analysis components.

Abstract: A method for segmenting an object of interest (which may be a liver object) in an input image is disclosed. The method comprises the steps of: (a) segmenting the points in a region of interest in the input image into a first and second group of points using predetermined intensity threshold values; (b) identifying a first set of small connected components formed by points in the first group of points and transferring the points in the first set of small connected components to the second group of points; (c) identifying a second set of small connected components formed by points in the second group of points and transferring the points in the second set of small connected components to the first group of points; and (d) forming the segmented object of interest using the first group of points.

Abstract: Disclosed is an apparatus and corresponding method to capture individual representational motions made by a person while performing a neuropsychological test. A user of the apparatus and method may be allowed to view, edit, classify, and retrieve any captured and recorded motions made by the person. In one embodiment, a capture unit, such as a digitizer, captures the motions made by a person while performing a Clock Drawing Test, and the captured data may then be reported in a myriad of ways. The apparatus and method also provide a means to standardize administration and scoring of writing utensil and paper based neuropsychological testing administered to a person or control and test groups for domestic or international applications. By analyzing individual representational motions made by a person while performing a neuropsychological test, unexpectedly more information may be gleaned from the test than was available to physicians from only a completed drawing.

Abstract: A medical image processing apparatus includes a difference calculator, a removal part, a first statistical processing part, and an estimation part. The difference calculator receives a plurality of medical image data with different imaging positions and obtains the difference between the plurality of medical image data, thereby generating difference image data that represents the difference. The removal part removes the region corresponding to a structure from the difference image data. The first statistical processing part obtains the first standard deviation of pixel values of each pixel of the difference image data with the region corresponding to the structure removed. The estimation part estimates the second standard deviation of the medical image data based on the first standard deviation. The medical image processing apparatus can estimate noise level of medical image data.

Abstract: A method, device, and computer program product for monitoring the physiological state of a subject is disclosed. A first plurality of physiological signals are acquired from the subject and a second plurality of signal parameters are determined based on the first plurality of physiological signals. Relevant signal information is selected from among the signal information produced and at least one screen page is displayed at a time, thereby to make at least part of the signal information visible to a user. The signal information visible to the user on the at least one screen page may then be revised based on the selection and without user interaction, thereby to accelerate clinical decision-making and to diminish the possibility of undetected changes in the state of the subject.

Abstract: Methods for evaluating and treating patients for dysphagia are provided. In a general embodiment, the method comprises screening the patient for dysphagia symptoms, diagnosing and categorizing the dysphagia if the patient exceeds a threshold of dysphagia symptoms, choosing the proper dysphagia treatment product based the patient's dysphagia, and giving the patient preparation instructions for the dysphagia treatment product.

Abstract: A computer implemented method, system, and/or computer program products derives a medical diagnosis for a patient. A current description of a patient is matched to a cohort of persons who each have a substantially similar description as the patient. Possible medical diagnoses, which have been accurate for members of the cohort, are presented for the patient. If one of the secondary medical diagnoses has an unacceptably high potential for an unacceptable outcome if improperly treated, then additional tests are run to rule out that secondary medical diagnosis.

Abstract: According to a radiographic apparatus of this invention, an image correcting unit corrects offset for every pixel relative to a detection value outputted from a radiation detector having pixels for detecting radiation arranged in a two-dimensional array. In addition, the image correcting unit corrects the offset while holding noise components contained in the detection value. Thus, upon quantitative evaluation of the noises contained in the detection values outputted from the radiation detector, the noises of not only positive values but also negative values can be considered. Consequently, accurate evaluation may be achieved.

Abstract: An implantable medical device monitors ST segment data collected from EGM. ST trends are established and monitored over time. The IMD is able to discern whether the data indicate supply ischemia, demand ischemia, or other physiological causes. The IMD is then able to provide appropriate information and alerts.

Abstract: Detecting patterns in sensed implantable medical device (IMD) data is described. One implementation involves an IMD that includes a data-driven pattern detection network embodied on the IMD to detect a pattern from sensed patient data. The IMD also includes one or more algorithms embodied on the IMD to utilize the pattern to effect patient therapy.

Abstract: A device, system and method for automatic detection of contractile activity of a body lumen in an image frame is provided, wherein image frames during contractile activity are captured and/or image frames including contractile activity are automatically detected, such as through pattern recognition and/or feature extraction to trace image frames including contractions, e.g., with wrinkle patterns. A manual procedure of annotation of contractions, e.g. tonic contractions in capsule endoscopy, may consist of the visualization of the whole video by a specialist, and the labeling of the contraction frames. Embodiments of the present invention may be suitable for implementation in an in vivo imaging system.

Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

Abstract: A system and method for evaluating a patient status from sampled physiometry for use in heart failure assessment is provided. Physiological measures are stored, including at least one of direct measures regularly recorded on a substantially continuous basis by an implantable medical device for a patient and measures derived from the direct measures. At least one of those of the physiological measures, which each relate to a same type of physiometry, and those of the physiological measures, which each relate to a different type of physiometry are sampled. A status for the patient is determined through analysis of the sampled physiological measures assembled from a plurality of recordation points. The sampled physiological measures are evaluated. Trends that are indicated by the patient status, which might affect cardiac performance of the patient, are identified. Each trend is compared to worsening heart failure indications to generate a notification of parameter violations.

Abstract: An presentation generator is disclosed for generating presentations for interacting with a user on a personal topic of, e.g., the user's selection, wherein the presentations assist the user in obtaining a greater awareness of his/her motivations and/or behaviors relating to the topic. In one embodiment, the presentation generator generates and presents to the user textual observations, questions, and/or statements for the user's consideration. Such presentations use and/or are consistent with textual descriptions obtained from: (a) the results of one or more personality/motivation test results, and (b) user inputs, e.g., regarding the selected topic together with his/her confidence in the validity of such inputs.

Abstract: A method and apparatus for providing an average signal characteristic profile derived from signals obtained from different cycles of a cyclically recurring physiological phenomenon. A signal produced from first and second cycles of the physiological phenomenon is sampled at a series of data points to obtain second physiological property values at the data points. The change in the second physiological property values for the first cycle signal between a pair of successive data points and the change in the second physiological property values for the second cycle signal between the same pair of successive data points are determined and averaged. The average change amount is applied to a value of the average signal characteristic profile at one of the pair of successive data points to produce a new second physiological property value for the average signal characteristic profile at the other of the data points of the pair.

Abstract: A programming system allows a user to program therapy parameter values for therapy delivered by a medical device by specifying a desired therapeutic outcome. In an example, the programming system presents a model of a brain network associated with a patient condition to the user. The model may be a graphical representation of a network of anatomical structures of the brain associated with the patient condition and may indicate the functional relationship between the anatomical structures. Using the model, the user may define a desired therapeutic outcome associated with the condition, and adjust excitatory and/or inhibitory effects of the stimulation on the anatomical structures. The system may determine therapy parameter values for therapy delivered to the patient based on the user input.

Abstract: Personal and family health history information can be used to assess familial risk of disease. For example, information can be collected about the disease history of a person and the person's first- and second-degree relatives and then analyzed to determine the familial risk of common diseases such as coronary heart disease, stroke, type 2 diabetes, and colorectal, breast, and ovarian cancer. Assessed familial risk of disease can then be used by researchers to better estimate the contribution of personal history and family history to the etiology and natural history of a disease of interest, and by consumers and health professionals to determine recommendations for disease management, prevention and screening that are personalized and targeted to the familial risk. Other embodiments are also described and claimed.

Abstract: An operator designates a reference plane on a medical image or a region of a patient, and a setting unit specifies whether the reference plane is an axial plane, a sagittal plane, or a coronal plane. The setting unit also specifies vertical, horizontal, and anteroposterior directions on the reference plane based on an anatomical characteristic of the region. Information about relationship between a patient coordinate system and a region coordinate system is stored in association with the medical image in a first storage unit.

Abstract: A system and method for providing computerized, knowledge-based medical diagnostic advice. The medical advice is provided to the general public over a network, such as a telephone network with the use of a telephone or the Internet with the use of an Internet access device. Alternatively, the medical advice can be provided to a patient in a stand-alone mode by use of a computer. The invention utilizes a list-based processing method of generating and executing diagnostic scripts. For the purpose of diagnosing a health problem of a patient, medical knowledge is organized into a list of the diseases to be considered. Each disease on the disease list includes a list of symptoms that is checked in a patient. Each symptom on the symptom list is then further described as a response to a list of one or more questions asked of the patient about the symptom. This triply-nested list structure is converted by suitable data structure transformations into a script that is stored.

Abstract: A stressor detection system (100) comprises sensor means (101) arranged for being attached to a person for obtaining a time-varying signal representing a physical quantity relating to an environment of the person, and processing means (102) for deriving a stressor value from the obtained signal representing a degree to which the environment is inducing stress in the person. The processing means is arranged for deriving an amount of complexity comprised in the signal, and for deriving a higher stressor value for a larger amount of information. The processing means is further arranged for performing a spectral frequency analysis of the signal and for deriving the stressor value also in dependence on the spectral frequency analysis. The sensor means comprises a microphone (105), a camera (104), and a tri-axial accelerometer.

Abstract: A medical image management system includes: a medical imaging device for imaging a patient to receive a medical treatment and creating a medical moving picture; and a recording unit for recording the medical moving picture imaged by the medical imaging device. The system further includes: a measurement unit for measuring biological information on a person who performs the medical treatment; and an indexing unit for adding an index to the medical moving picture recorded in the recording unit, according to the measurement result obtained by the measurement unit. By providing this system, it is possible to add an index to the medical moving picture recorded, according to the change of the biological information on the person who performs medical treatment on a patient.

Abstract: Techniques for determining whether one or more leads are not adequately connected to a patient, e.g., for ECG monitoring, are described. The techniques involve injection of an integrated signal (which includes a test signal) into one lead, and monitoring the driven lead and the response at the other leads, including the common mode and the difference between the other leads. These “lead-off” detection techniques may be provided by an external defibrillator that provides three-wire ECG monitoring. Techniques for determining a type of a cable coupled to a defibrillator are also described. The cable-type identification may allow a defibrillator to, for example, operate in either a three-wire ECG monitoring mode or a therapy mode, based on whether a three-wire ECG cable or a defibrillation cable is coupled to the defibrillator.

Abstract: An object of the present invention is to easily maintain the couch positioning accuracy and reduce the couch positioning time while resolving the complexity of input operations by the operator at the time of couch positioning. To accomplish the above object, calculation points are set to a CT image at the time of treatment planning, and the 3D coordinates of the set calculation point are set to a DRR image. When a couch positioning unit 115 loads the DRR image from an image server 109, it reads the coordinates of calculation points set to the DRR image and displays them on the monitor 116 together with the DRR image. Further, when DR image data is loaded into the couch positioning unit 115, the DR image is displayed on the monitor 116 and calculation points set to the DRR image are set also to the DR image.

Abstract: A health activity plan may be prescribed for an individual comprising a set of health activity instances (e.g., physical therapy exercises, an exercise regimen, or a wound management program.) The performed health activity instances of the individual may be tracked by a device, and may be presented to a user of the device in correlation with the health activity plan (e.g., to demonstrate compliance of the individual with the health activity plan.) The health activity information may be presented using a set of icons that depict the health activity information, which may improve an easier understanding and a more consistent communication of health activity information among the individual and healthcare providers.

Abstract: A system and method for collection and analysis of patient information for automated remote patient care is disclosed. Patient care records in a database are collected. Each patient care record is defined and includes collected measurements sets. Each collected measurements set is specified and includes individual measurements, which each relate to patient information recorded by a medical device adapted to be implanted. At least one of the collected measurements sets is processed. A set of the collected measurements regularly stored and periodically sent from the implantable medical device is received. The collected measurements set are stored into the patient care record. One or more of the collected measurements sets are analyzed in the patient care record for the individual patient relative to one or more other collected measurements sets stored in the patient care record. Feedback based on the analysis of the one or more collected measurements sets is sent.

Abstract: A method comprises monitoring a heart rate, a respiration rate and an activity level of a patient, comparing the monitored heart rate, respiration rate and activity level to a predetermined threshold zone which is a function of heart rate, respiration rate and activity level, determining the patient is experiencing worsening heart failure when the monitored heart rate, respiration rate and activity level are outside the predetermined threshold zone; and after determining the patient is experiencing worsening heart failure when the monitored heart rate, respiration rate and activity level are outside the predetermined threshold zone, issuing an alert to indicate that the patient is experiencing worsening heart failure.

Abstract: A method for assessing a rupture risk of at least one aneurysm of a patient, with the rupture risk being assessed by a computing device as a function of at least one personal factor specific to the patient and at least one anatomy-linked factor relevant to the anatomy of the and/or in the area of the at least one aneurysm and at least one simulation-linked factor determined with reference to at least one simulation carried out by means of the computing device and/or a further computing device and based on anatomical data for the at least one aneurysm.

Abstract: A system and method for evaluating a patient status from sampled physiometry for use in respiratory insufficiency management and heart failure assessment is presented. Physiological measures are stored and include direct measures regularly recorded on a substantially continuous basis by a medical device for a patient or measures derived from the direct measures. The physiological measures are sampled, which each relate to a same type of physiometry, and those of the physiological measures, which each relate to a different type of physiometry. A status is determined through analysis of those sampled physiological measures assembled from a plurality of recordation points. The sampled physiological measures are evaluated. Any trends are identified and include one of a status quo and a change, which might affect cardiac performance or respiratory performance.

Abstract: An automated patient care system and method for diagnosing and monitoring respiratory insufficiency is presented. A plurality of monitoring sets are stored into a database. Each monitoring set includes recorded measures, which each relate to patient information and contain medical device measures recorded on a substantially continuous basis or derived measures calculable therefrom. The monitoring sets are retrieved from the database. A set of indicator thresholds are defined. Each indicator threshold corresponds to a quantifiable physiological measure of a pathophysiology indicative of respiratory insufficiency. A respiratory insufficiency finding is diagnosed. A change in patient status is determined by comparing at least one recorded measure to at least one other recorded measure with both recorded measures relating to the same type of patient information. Each patient status change is compared to the indicator threshold corresponding to the same type of patient information as the recorded measures.

Abstract: A cardiac pacemaker, defibrillator, or other programmable medical device (25) includes a source unit (15) and a collection unit (20). The source unit (15) has a check data unit (40) generating at least one check datum for control data for the medical device (25), and a transmitting unit (45) transmitting the control data and the check datum to the collection unit (20). The collection unit (20) has a storage unit (65) storing the control data, a check unit (70) checking the integrity of the control data using the check datum, and a transmitting unit (75) transmitting the control data to a programmable control unit (80) of the medical device (25) only if the integrity of the control data is established by the check unit (70). The control unit (80) of the medical device (25) controls the functions of the medical device (20) on the basis of the transmitted control data.

Abstract: A method and apparatus are disclosed that reduces variation in radiation therapy treatment planning among plurality of users within the same or different geographic locations. The system includes a method and an apparatus that provide users with the knowledge information and utilizing the knowledge information to contour target volumes for radiation treatment planning. The mode of operation includes utilizing a stand-alone workstation or a server computer connected to the plurality of thin client workstations.

Abstract: A method of classifying arrhythmias using scatter plot analysis to define a measure of variability of a cardiac rhythm parameter such as for example, without limitation, R-R interval, A-A interval, and the slope of a portion of a cardiac signal, is disclosed. The variability measurement is derived from a scatter plot of a cardiac rhythm parameter, employing a region counting technique that quantifies the variability of the cardiac rhythm parameter while minimizing the computational complexity. The method may be employed by an implantable medical device or system, such as an implantable pacemaker or cardioverter defibrillator, or by an external device or system, such as a programmer or computer. The variability measurement may be correlated with other device or system information to differentiate between atrial flutter and atrial fibrillation, for example. The variability information may also be used by the device or system to select an appropriate therapy for a patient.

Abstract: A reference point-designating section 18b designates two reference points on a measurement object. A reference curve-calculating section 18c calculates a reference curve calculated by approximating an outline of the measurement object based on the reference points. A loss-composing point-calculating section 18d calculates loss-composing points constituting a loss outline formed on the measurement object based on the reference points and the reference curve. A loss size-calculating section 18f measures loss size based on the loss-composing points. Designating two reference points enables loss size measurement, thereby reducing complex operation and improving operability.

Abstract: The systems and methods described herein provide for fast and accurate image segmentation through the application of a multi-stage classifier to an image data set. An image processing system is provided having a processor configured to apply a multi-stage classifier to the image data set to identify a distinctive region. The multi-stage classifier can include two or more component classifiers. The first component classifier can have a sensitivity level configured to identify one or more target regions in the image data set and the second component classifier can have a specificity level configured to confirm the presence of the distinctive region in any identified target regions. Also provided is a classification array having multiple multi-stage classifiers for identification and confirmation of more than one distinctive region or for the application of different classification configurations to the image data set to identify a specific distinctive region.