Disposable Apparatus Or Apparatus Having Removable Section (e.g., Removable Cartridge, Etc.) Patents (Class 204/403.02)
  • Patent number: 9034172
    Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: May 19, 2015
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Yuan Wang, Raeann Gifford, Hualin Jiang, Jeffery S. Reynolds, Jianfeng Fei
  • Publication number: 20150114836
    Abstract: A system for obtaining a pH measurement comprises a disposable probe and a reader. The disposable probe includes at least one indicating electrode and at least one reference electrode. The reader is configured to operably engage with the disposable probe and provide pH information of a sample.
    Type: Application
    Filed: September 6, 2012
    Publication date: April 30, 2015
    Inventors: William Clark, Sung Kwon Cho, Yuejun Zhao, Timothy J. Syciarz, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20150096906
    Abstract: A test strip comprising two electrodes having conducting surfaces facing inwardly toward each other in a portion of the test strip adjacent a sample chamber. A pair of spacers are disposed, each adjacent one side of the sample chamber, between the electrodes. The electrodes bypass each other at a proximal end of the test strip away from the sample chamber so that the conducting surfaces face outwardly away from each other to form electrical contact areas of the test strip.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 9, 2015
    Applicant: Cilag GmbH International
    Inventors: Russell BAIN, Scott Sloss
  • Publication number: 20150096888
    Abstract: A blood glucose test device with viewing lens seal includes a meter body rigid portion of a first polymeric material and an opening. A resilient portion of a second polymeric material more compressible than the first polymeric material integrally connected to the rigid portion defines a rigid portion outer covering. A resilient portion edge extends beyond the rigid portion and partially into the opening about a perimeter of the opening. A transparent polymeric material lens has an outer perimeter surface in contact with the resilient portion edge. Multiple flexible arms extending from the lens each have a hook member. Each hook member engages a receiving member positioned in a meter body and is retained by multiple backup ribs. Hook member engagement at a locking position pulls the lens toward the edge partially compressing the second polymeric material and creating a fluid seal between the perimeter surface and edge.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 9, 2015
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Christopher L. Belisle, Craig A. Carson, Robert G. Davies, Joel S. Gerich, Timothy L. Ranney
  • Publication number: 20150094553
    Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 2, 2015
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Benjamin Jay Feldman, Shridhara Alva Karinka, Yi Wang, John R. Galasso
  • Patent number: 8992750
    Abstract: Embodiments of the invention include a test strip with a sample chamber opening spanning the width of the test strip at the sampling end and including a portion of the lateral sides at that end. The chamber is vertically bounded by upper and lower substrate layers, horizontally bounded by the front face of a spacer layer, and open on the remaining sides. The test strip fills rapidly and requires small sample volumes. Both 1-up and 2-up manufacturing techniques for producing such test strips eliminate registration and alignment steps, and other techniques relating to the 2-up technique (simultaneously manufacturing test strips arranged in multiple columns) are also disclosed.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: March 31, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Terry A. Beaty, Eric R. Diebold, Abner D. Joseph, Randall K. Riggles
  • Publication number: 20150083590
    Abstract: A device assembly for measuring and monitoring glucose content of blood, and a cover of such an assembly. The assembly is especially applicable for users with diabetes disease. The assembly includes a resilient cover on a measurement device. The cover has a slit at the input for a blood sample strip. The slit is closed at its rest position, but a test strip can be entered through the slit based on the resilience of the cover material. The resilient cover absorbs possible mechanical impacts and prevents impurities from reaching the sensor electronics.
    Type: Application
    Filed: March 23, 2012
    Publication date: March 26, 2015
    Applicant: Modz Oy
    Inventors: Carina Rajala, Salla Koski, Mikko Tasanen
  • Publication number: 20150076010
    Abstract: An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 19, 2015
    Inventors: John T. Austera, Terry A. Beaty, Abner D. Joseph, Nathan E. Manlove, Steven K. Moore, James L. Pauley, JR., Randall K. Riggles
  • Publication number: 20150076008
    Abstract: A plug side surface of a plug housing is provided with a claw portion. The claw portion includes a plug lock surface facing in a direction away from a connector mounting surface. Each assistant fitting of a receptacle connector includes a receptacle lock surface that faces in a direction approaching the connector mounting surface and is opposed to the plug lock surface in a mated state. The plug lock surface includes a lock maintaining surface and an unlocking surface. Assuming that an angle formed between a reference plane and the lock maintaining surface is a lock maintaining angle and an angle formed between the reference plane and the unlocking surface is an unlocking angle, the lock maintaining angle is smaller than the unlocking angle.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 19, 2015
    Inventors: Panteleimon Athanasiou, Alpesh Patel, David Whitaker, Hua Bai, John Palmer-Felgate, Daniel Coomber-Alford, Jessica Fisher, Chad Schenider, Alex Flamm, Ben Lane, Sam Reed
  • Patent number: 8980074
    Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 17, 2015
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi
  • Publication number: 20150068894
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Ayub Khattak, Clinton Sever
  • Publication number: 20150072406
    Abstract: Provided is a portable diagnostic test apparatus including: an accommodation portion including an outer side, an inner side, and an accommodation space provided on the inner side; a hinge; and a main body coupled to the accommodation portion by the hinge, where the portable diagnostic test apparatus is configured to be opened and closed by rotating one of the accommodation portion and the main body about the hinge, and where the main body is configured to obtain a result of a measurement based on data collected from drawn blood. The main body and/or the accommodation portion includes at least one strip keeping portion configured to store at least one strip. The at least one strip keeping portion may include: a housing; a discharge portion; and a first movement portion configured to move one of the strips to the discharge portion.
    Type: Application
    Filed: April 3, 2014
    Publication date: March 12, 2015
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: In Duk HWANG, Yeon Moo CHUNG, Na Hui KIM, Jeong Je PARK, Chul Ho YUN
  • Publication number: 20150068922
    Abstract: Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 12, 2015
    Applicant: LifeScan Scotland Limited
    Inventor: Stephen MACKINTOSH
  • Patent number: 8956518
    Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 17, 2015
    Assignee: LifeScan, Inc.
    Inventors: Garry Chambers, Alastair M. Hodges, Ronald C. Chatelier
  • Publication number: 20150027907
    Abstract: Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Ronald C. Chatelier, Dennis Rylatt, Linda Raineri, Alastair M. Hodges
  • Patent number: 8940142
    Abstract: Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction withy peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of Il-10 at a concentration of 4ng/nl is also disclosed, as is detection of VEGF.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: January 27, 2015
    Assignee: The Regents of the University of California
    Inventors: Miloslav Karhanek, Chris D. Webb, Senkei Umehara, Nader Pourmand
  • Publication number: 20150021179
    Abstract: An electrochemical strip is disclosed. The electrochemical strip includes a substrate and an electrode deposited on the substrate. The electrode includes a conductive paste layer, a first metal layer, a second metal layer, a third metal layer, and a fourth metal layer. The conductive paste is made of a material selected from the group consisting of copper paste, nickel paste, silver paste, and silver-carbon paste. The first metal layer is made of a group VIII metal. The second metal layer is made of nickel. The third metal layer is made of a group VIII metal. The fourth metal layer is made of a material selected from the group consisting of palladium, gold, and platinum.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 22, 2015
    Inventor: Chuan-Hsing HUANG
  • Publication number: 20150021205
    Abstract: A method of measuring lactate in a blood sample taken from capillary blood using a skin lancing procedure includes disposing onto an area of skin on an animal a predefined amount of a skin treatment compound that is capable of suppressing and/or eliminating and/or preventing and/or blocking any sweat from the skin in the area of a lanced wound site, the compound being disposed on the skin either before lancing the area of skin that provides a droplet of capillary blood for measurement of blood lactate concentration or after lancing the area of skin but before a droplet of capillary blood forms on the skin in order to prevent contaminating the blood sample, and then measuring the lactate concentration of the blood sample with a disposable lactate sensor strip.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 22, 2015
    Applicant: Nova Biomedical Corporation
    Inventors: Jianhong Pei, Chung Chang Young
  • Patent number: 8932445
    Abstract: Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a measurement of a parameter correlating to changes in a physical property of the sample analyzing device is calculated. A concentration of the analyte in view of the parameter correlating to a change in the physical property can then be determined Systems and devices that take advantage of the parameter correlating to changes in a physical property to make analyte concentration determinations are also provided.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: January 13, 2015
    Assignee: Cilag GmbH International
    Inventors: Ronald C. Chatelier, Alastair M. Hodges
  • Patent number: 8926808
    Abstract: An electrochemical paper-immunosensor and method for detecting aminoglycoside antibiotics is developed in the present invention. Single-walled carbon nanotubes are coated on the common filtration paper by dip-dry cycles. With antibody against neomycin adding to the coating solution, a high sensitive biosensor for specific detection of neomycin is prepared, satisfying to the rigid authority regulations. The sensor is not only sensitive but also rapid, comparing with the classic ELISA method, with LOD of 0.04 ng mL?1 and the whole detection process lasting less than 30 min. Another notable advantage of this invention is the versatility of the sensor, similar method is engaged to prepare the versatile sensor for other aminoglycoside antibiotics, replacement with relevant antibodies.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: January 6, 2015
    Assignee: Jiangnan University
    Inventors: Chuanlai Xu, Libing Wang, Xiaoling Wu, Hua Kuang, Wei Chen, Wei Ma
  • Patent number: 8926369
    Abstract: An electrical connector can receive a substrate having conductive tracks. The connector includes a housing with a port and at least one alignment feature that together define a direction of insertion. At least three function pins mounted to the housing each include contacts that electrically connect to one of the conductive tracks of a substrate inserted in the connector. A sense pin mounted to the housing has a contact that electrically connects to at least one of the conductive tracks of an inserted substrate. The sense pin can include a plurality of electrically-connected segments, each segment extending substantially parallel or substantially perpendicular to the direction of insertion of the substrate. Systems and methods for detecting an analyte in a bodily-fluid sample are also described.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: January 6, 2015
    Assignee: LifeScan Scotland Limited
    Inventors: Gary Carroll, Ivan Confield, Luca Valsecchi, Michele Sala, Maurizio Volpe, Roberto Beretta, John Nelson
  • Publication number: 20140374278
    Abstract: An analyte meter with a test strip port that detects an orientation of a test strip inserted therein. A control circuit of the test meter is configured to apply a first predetermined analyte measurement signal to a test strip electrode in response to detecting a first orientation of the test strip, and a second predetermined analyte measurement signal to the same, or a different, electrode in response to detecting a second orientation of the test strip.
    Type: Application
    Filed: June 19, 2013
    Publication date: December 25, 2014
    Inventors: James Iain RODGERS, Lawrence RITCHIE, Anna ZVIKHACHEVSKAYA, Jonathan NELSON, Carlos MORALES
  • Patent number: 8916036
    Abstract: An analyte test instrument that has a test strip circuitry that can be configured using information provided by a calibration strip to perform assays with test strips having two electrodes and test strips having three electrodes. The analyte test instrument of this invention comprises: (a) a test port for receiving a test strip; (b) a microprocessor for executing instructions downloaded into the analyte test instrument; (c) a test strip circuit capable of having a plurality of configurations, the configurations being set by the microprocessor, whereby an assay can be performed using the test strip.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: December 23, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Shridhara Alva Karinka, Gurdial Sanghera
  • Publication number: 20140360872
    Abstract: A cartridge configured to be inserted into a meter, the cartridge comprising: a housing having at least two electrical contacts disposed on an inner surface of a wall of the housing and at least two electrical contacts disposed on an outer surface of the wall of the housing, wherein a conductive path is provided between corresponding ones of the at least two electrical contacts on the inner and outer surfaces; and at least one testing member supported within the housing, each testing member having at least two contact pads configured to engage with the at least two electrical contacts disposed on the inner surface of the housing wall when that testing member is moved into a measurement position, wherein the at least two electrical contacts disposed on the outer surface of the housing wall are configured to provide a conductive connection between the testing member and the meter.
    Type: Application
    Filed: January 9, 2013
    Publication date: December 11, 2014
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Frank Richter, Ross MacArthur, Elizabeth Verity Wolseley-Hext, Joseph David Cowan, Lee Thomas Smith, David John Mills
  • Patent number: 8906210
    Abstract: A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 9, 2014
    Assignee: Edwards Lifesciences Corporation
    Inventor: Kenneth M. Curry
  • Publication number: 20140353153
    Abstract: Apparatus and methods are described for preparing, maintaining, and stabilizing sensors. The apparatus and methods for preparing sensors for use are utilized in advance of the sensor being removed from a sealed, sterilized package. The apparatus include packaging materials having electrical circuits capable of stabilizing a sensor to prepare the sensor for use. The methods for preparing a sensor for use includes methods of providing a solution to a sterilized packaging that contains a sensor connected to a sensor activating circuit, activating the circuit, and allowing the sensor to stabilize. These methods can be performed without compromising the packaging. The apparatus for stabilizing a sensor that is in use include a circuit connectable to the sensor that provides a signal to the sensor that prevents the sensor from becoming destabilized when disconnected from a monitoring device.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Applicant: Edwards Lifesciences Corporation
    Inventors: Michael Higgins, Mark A. Konno, Todd Fjield
  • Publication number: 20140353176
    Abstract: A hand-held test meter for use with an analytical test strip in determining an analyte in a fluid sample includes a housing retaining a microcontroller block and a phase-shift-measurement block. The measurement block includes a signal-generation sub-block that provides an excitation voltage signal; an interface sub-block that receives the analytical test strip and permits applying the voltage excitation signal to the test strip to provide a resultant current signal; a transimpedance conversion sub-block that receives the resultant current signal and provides a resultant voltage signal; and a phase detector responsive to the resultant voltage signal and a reference signal. The microcontroller block successively provides 0°- and 90°-phase reference signals as the reference to the phase detector to measure in-phase and quadrature components and determine a phase shift corresponding to a fluid sample in the received analytical test strip.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 4, 2014
    Inventors: David ELDER, Rossano Massari
  • Patent number: 8899290
    Abstract: A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: December 2, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wolfgang Schwoebel, Joerg Dreibholz
  • Patent number: 8900430
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: December 2, 2014
    Assignee: Panasonic Healthcare Holdings Co., Ltd
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Patent number: 8894831
    Abstract: A test strip for analyzing a biological fluid using a test meter includes a biosensor to sense the biological fluid. The test strip includes contacts to communicate with the test meter and conductors connected to the contacts. The test strip further includes a combination of diodes, resistors, and short circuits arranged in various ways between the conductors. The test strip stores data based on a number of connections severed between the diodes, the resistors, the short circuits, and the conductors. The test meter reads the data and communicates with the biosensor via the contacts.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: November 25, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Michael J. Celentano, Herbert Harttig, Brian A. Wittman
  • Patent number: 8888972
    Abstract: The present invention provides there is provided an electrochemical biosensor electrode structure that includes: a working electrode and a reference electrode used as electrodes for sample measurement being arranged separately from each other in lengthwise direction of a sample insertion path, the working electrode and the reference electrode each having at least one projection and at least one recess alternately arranged on a portion thereof corresponding to the sample insertion path, the projection of the working electrode being correspondingly adjacent to the recess of the reference electrode, the recess of the working electrode being correspondingly adjacent to the projection of the reference electrode; and at least two sample recognition electrodes used as electrodes for sample recognition being separated from each other and arranged adjacent and parallel to the working electrode and the reference electrode.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: November 18, 2014
    Assignee: Center for Integrated Smart Sensors Foundation
    Inventors: Young Tae Lee, Seungro Lee
  • Patent number: 8888973
    Abstract: An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: November 18, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: John T. Austera, Terry A. Beaty, Abner D. Joseph, Nathan E. Manlove, Steven K. Moore, James L. Pauley, Jr., Randall K. Riggles
  • Patent number: 8888974
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 18, 2014
    Assignee: Panasonic Healthcare Holdings, Co., Ltd
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Patent number: 8888975
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 18, 2014
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Publication number: 20140332409
    Abstract: The present invention is directed to a method and apparatus for an immunoassay technique that uses amperometric measurements to rapidly analyze different pathogenic microorganisms, including bacteria, viruses, toxins, and parasites and chemical compounds using a disposable element. In accordance with one aspect of the present invention, at least one conductive immunosorbent is used to provide support for antibody immobilization and placed on the top of the working electrode; it could also be used by itself as a working electrode. This immunosorbent or powder can be fabricated of conductive material or nonconductive material over which a conductive material is coated. A membrane cover of the working electrode forms a fluidic chamber having a pore size that is suited to the particular application to insure no contact between the working electrode and counter or silver electrode. The immunoassay can be automated using microprocessor control to reduce the amount of human intervention.
    Type: Application
    Filed: May 13, 2013
    Publication date: November 13, 2014
    Inventor: Ebtisam Wilkins
  • Publication number: 20140332414
    Abstract: A disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance, but no additional air escape vent. The chamber provides a reservoir from which a sample fluid can be drawn into the chamber through capillary action. The sampling entrance provided can draw fluid into the chamber through any part of the opening, allowing easy targeting the samples with small volume, picking up smeared samples, and added tolerance to users who jam the tip of the sensor into users' finger. The sampling entrance also serves as air escape vent. Such one opening sensor alleviates over-flow issue often encountered in convenient sensors.
    Type: Application
    Filed: May 9, 2013
    Publication date: November 13, 2014
    Applicant: CHANGSHA SINOCARE INC.
    Inventors: Hongli Che, Shaobo Li
  • Publication number: 20140332415
    Abstract: A method and system are provided to determine fill sufficiency of a biosensor test chamber by determining capacitance of the test chamber.
    Type: Application
    Filed: April 7, 2014
    Publication date: November 13, 2014
    Applicant: LifeScan Scotland Limited
    Inventors: David ELDER, Sven RIPPEL
  • Patent number: 8882987
    Abstract: A biosensor measurement system and a method for detecting abnormal measurement in a biosensor, which can significantly enhance the measurement precision without depending on the user's operation manner or the like, can be provided. A voltage application pattern for applying a voltage to a working electrode, a counter electrode, and a detection electrode has a halt period between a first application period and a second application period, and a reduction current measurement value obtained in the first application period is compared with a reduction current measurement value obtained in the second application period, and the measurement values are not outputted when a difference between the measurement values is outside a predetermined range.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: November 11, 2014
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Toshiharu Yoshioka, Eriko Yamanishi, Hiroyuki Tokunaga
  • Publication number: 20140318991
    Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicants: ROCHE OPERATIONS LTD., ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Michael J. Celentano, Henning Groll, James L. Pauley, Steven K. Moore
  • Publication number: 20140318987
    Abstract: An analyte meter having a test strip port is configured to detect whether an approved test strip has been inserted into the test strip port before turning on analyte measurement subsystems in the analyte meter. After the meter is turned on, control circuitry in the meter continues to monitor whether the test strip is removed prior to application of a blood sample on the test strip or whether the test strip is removed after application of a blood sample on the test strip, such as during an assay of the sample.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 30, 2014
    Applicant: LifeScan Scotland Limited
    Inventors: Brian Guthrie, Malcolm Hamer, Yeswanth Gadde, Alexander Strachan, Tomasso Borghi, Stuart Robb
  • Publication number: 20140318986
    Abstract: An analyte meter is configured to digitally test for the presence of a test strip in the meter and for the presence of a sample in the test strip prior to activating an analog current measurement circuit of the meter. A test strip port connector having a plurality of contacts receives an inserted test strip in which the contacts electrically connect to electrodes on the test strip for digitally detecting both the presence of a test strip and a sample added to the test strip. A control circuit monitoring the contacts maintains the analyte meter in a low power mode until detecting both the test strip and the sample, whereupon the control circuit activates the meter and enables an analog analyte measurement circuit.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 30, 2014
    Applicant: LifeScan Scotland Limited
    Inventors: David Elder, Stanley Young, Ciaran Carney, Brian Guthrie, Steven Milne, John Young
  • Patent number: 8871068
    Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 28, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
  • Publication number: 20140311924
    Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.
    Type: Application
    Filed: March 20, 2012
    Publication date: October 23, 2014
    Applicant: Cilag GmbH International
    Inventors: David Matzinger, Maria Teodorczyk
  • Publication number: 20140299483
    Abstract: An analyte meter having a test strip port is configured to transmit an electric signal through a received test strip with a sample. A pair of electrodes apply the electric signal and receive an electrical response from the test strip. A processing unit analyzes the electrical response and uses the response to determine an analyte level of the sample.
    Type: Application
    Filed: April 5, 2013
    Publication date: October 9, 2014
    Applicant: LifeScan Scotland Limited
    Inventors: Tim Lloyd, David McColl, Antony Smith, Brian Guthrie, David Elder, Rossano Massari, Christian Forlani
  • Patent number: 8852510
    Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analysis of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: October 7, 2014
    Assignee: AgaMatrix, Inc.
    Inventors: Ian Harding, Sridhar G. Iyengar, Baoguo Wei, Steven Diamond, Martin Forest
  • Publication number: 20140262829
    Abstract: A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system may include a vial having an optional first compartment and a second compartment comprising a growth medium comprising one or more of a disaccharide, an oligosaccharide or a polysaccharide capable of conversion to a monosaccharide by germinating spores of the one or more species of microorganism, the vial being free of the monosaccharide prior to use; a strip including two or more electrodes to oxidize the monosaccharide and to carry a resulting electrical signal, and an apparatus to detect and measure the electrical signal resulting from the oxidation. Spores of a suitable biological indicator may be disposed in the first compartment and/or on the strip.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: AMERICAN STERILIZER COMPANY
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Publication number: 20140255962
    Abstract: Test elements are disclosed for detecting at least one analyte in a body fluid. The test element include at least one strip-shaped carrier element and at least one test field having at least one test chemistry for detecting the analyte. The test element has a symmetrical shape such that the test element may be inserted in one of at least two different correct measurement orientations into a test element receptacle of a testing device, which includes a detection device. In the different orientations, at least one analyte-induced change in the test chemistry of the test field is detectable. Test systems including the test elements and methods of detecting at least one analyte in the body fluid using the test elements also are disclosed.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Frank Rueckert, Bruno Thoes
  • Patent number: 8828202
    Abstract: A dissolved oxygen sensor for use with a single use-bioreactor/container is provided. The bioreaction vessel includes a plastic wall defining a bioreaction chamber therein, and having an aperture therethrough. A membrane holder is attached to an inner surface of the plastic wall. The membrane holder has a cylindrical portion passing through the aperture. A sensor window membrane is coupled to the membrane holder proximate the aperture. The sensor window membrane has a high oxygen permeability, but forms a water-tight seal with the membrane holder.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: September 9, 2014
    Assignee: Rosemount Analytical Inc.
    Inventor: Chang-Dong Feng
  • Publication number: 20140238855
    Abstract: For measuring concentrations of fluid-soluble gases with improved drift stability and low production costs, thus dispensing with tedious calibration and/or drift correction routines and re-membraning procedures, a sensor and a system are provided, comprising at least two electrodes, which are covered by sensor fluid at at least one detection site; and an ion-balancing means (50), for example a mixed-bed ion-exchange resin, in contact with the sensor fluid for removing polluting ions.
    Type: Application
    Filed: October 26, 2012
    Publication date: August 28, 2014
    Inventors: Niek Lambert, Laurentina Johanna Huijbrechts, Joost Kahlman, Hans Willem Van Kesteren, Anton Vink
  • Publication number: 20140238874
    Abstract: A blood analyte measurement system is configured to receive a test strip. An LED proximate to the test strip is used to illuminate the test strip and, in conjunction with a photodiode, to determine its type. A compensation circuit of the measurement system insures that ambient light does not cause interference with the LED illumination to prevent saturation of the photodiode.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Applicant: LifeScan Scotland Limited
    Inventors: David Elder, Lawrence Ritchie, Paul Knight