Abstract: A closure of plastic material for monodose bottles and the like, provided with a reservoir (2) with a breakable bottom (3) housed in the neck (4) of the bottle (5) and showing an annular upper edge (6) superimposed to the annular edge (7) of the bottle opening; with a cylindrical element (8) with its lower end (9) sideways cut inserted into the reservoir (2) and including further a sealing cap (10) positioned around the bottle neck (4) and covering said cylindrical element (8), a weakening line apt to allow the tearing removal being provided in said cap.

Abstract: A system for introducing flowable additive e.g. colorant from a syringe into paint varnish, woodstain or the like contained in a closed container provided with an inlet into the container which inlet is closed by a closure. The inlet is openable by insertion of the nozzle of the syringe into the inlet which thereby ensures that the nozzle of the syringe is correctly located in the inlet before expulsion of the additive commences.

Abstract: The process for producing two compartment easily ruptured paintball type projectiles that are fired from compressed air guns; this invention provides a double chamber projectile capsule that contains two chemical agents which, when mixed together on impact, provide a luminescent spot to visibly mark impacts at night; for police and military training, as well as the popular adult war games, based on the present paint ball and air gun equipment. The unique modifications are designed to fit into the present standardized paintball specifications, without adding unusual expense. A double barrier feature assures necessary shelf life and complete separation of the reactive agents; as well as increased ease of loading the two chemical agents during manufacture.

Abstract: A unit dose package, which is usable with a bottle to reconstruct the contents of the package, has a plastic fitment which defines a mouth opening for the package. The plastic fitment is bonded to a wall of the package and has a channel which receives the neck of the bottle. A flexible foil membrane seal is removably attached to this plastic fitment and is covered by a protective overcap.

Abstract: Syringe mixer and injector device formed of an injector and an adaptor having opposed interconnectable nozzles, e.g. with mating luer lock connectors, on their facing ends and sockets in their remote ends. Each of the injector and adapter has a protected fluid pathway flow connecting its nozzle and socket, a guideway to receive at its remote end for movement thereon a medicament vial when the vial stopper is connected to its socket, and a recessed short tubular spike forming the pathway portion in its socket and protruding into the socket and terminating inwardly from its remote end sufficiently to protect the spike from unintended human contact and arranged to penetrate the stopper thereat to flow connect its vial with its pathway in protected condition. After charging the injector connected vial with the contents of the adapter connected vial, e.g.

Abstract: An assembly in-situ preparation of suspensions and solutions of an active, solid, product in a liquid product, each of the products being separately contained in a hermetic flask, with connecting means permitting the placing in communication of the two flasks, which means consists of a single piece (1) molded of plastic material with an upper portion (2) internally threaded for coupling with the neck of the flask (7) containing the liquid and a lower portion (3) capping the neck of the flask containing the solid product, the molded connecting piece is closed by a sealed elastomer stopper and an inner shoulder hooking over one or several small collars on the neck.

Abstract: A multiple compartment container for pourable substances, particularly liquids, comprising first and second container portions, at least one foil for separating said first and second container portions, a severing device for severing the foil, a spindle for rotatably supporting the severing device, and a rotatable activating device connected with the severing device for joint rotation therewith.

Abstract: The packaging for the liquid composition which is ready for use, produced by some suitable dilution and mixing in a support product such as water of a concentrated liquid composition, comprises a bottle (1) having an overall rigidity which gives it a self-supporting property, the bottle having a hollow body (2) of known volume, having an opening (3) and a removable cap (4), the bottle (1) being intended to finally receive the composition which is ready for use and to permit the preparation of the latter; a container (6) of smaller size than the bottle (1), having an overall rigidity which gives it a self-supporting property, the container having a hollow body (8) for receiving the concentrated liquid composition, in the extension of the body (2), having an opening (9), an integral measuring device (11) fixed rigidly in the opening (9), a removable cap (10) closing the measuring device (11); a hollow recess (17) in the body (2) in which the container (6) may be accommodated, this recess (17) having an opening

Abstract: A container apparatus for introducing a metered quantity of a product into a vessel such as a mixing and diluting tank without includes a capsule which is in two parts joined together by screwing and which is integral with a clamping collar screwed onto a neck (2) of the vessel. A first one of the parts of the capsule rotates together with the clamping collar during the screwing, whereas the second part is immobilized in terms of rotation relative to the vessel, and the screw pitches are such that the screwing of the clamping collar onto the neck causes the separation of the two parts the capsule and opens slots in the second part so that the product contained in the capsule can flow therethrough.

Abstract: There is described a package and method of packaging that provide, in inexpensive form, means for adding accurate amounts of one material to another. The package, which can come as a kit to be added to a lyophilizing bottle and stopper, features a portion that is added to the bottle outlet to confine the material that is to be stored separate from the contents of the bottle. That portion includes a plunger preferably constructed to provide a dual function: that of sealing the stopper against the bottle outlet, and of permanently attaching to the stopper to remove it from the bottle when the plunger is moved within the upper portion. Because of its hollow configuration, the plunger can be used to pour off the resulting mixture.

Abstract: A dispensing insert for use with a baby bottle for dispensing solid or liquid materials which insert fits between the bottle and the nipple cap. The insert having openings therethrough for communications with the material to be dispensed and the liquid in the bottle to permit of controlled dispensing of the material carried by the insert.

Abstract: A multichamber container with no compressed gas therein comprises an outer container and an inner container for pourable substances which are to be kept separate. The substances may be combined inside the container for the purpose of extracting a mixture of substances. The inner container has an open end which is connected to an inner side of a cap with positive locking, in a non-rotatable and axially detachable manner, and has at least one projection on the outside wall. The outer container is connected to the rotatable cap by means of a snap connection and has at least one projection on the inside wall. The projectins of both containers are formed in such a manner that they intercommunicate for combining the substances by rotation of the cap. The inner container is axially detachable from the cap.

Abstract: A receptacle for retaining a material comprising, a bottle having a flat base for placement of the bottle on a support surface, and sidewalls defining a chamber increasing in inner dimensions from the base toward an upper location of the bottle, with the portion of the sidewalls of increasing dimension including at least half of the total size of the chamber. The receptacle has a thixotropic material received in the chamber.

Abstract: A vial holder for a septum closed vial is disclosed which vial holder enables automated vial insertion to and withdrawal from puncturing hypodermics for the removal of contents or the communication of electrodes to liquids within the sealed vial. The vial--a commercial item of manufacture--includes a cylindrical glass body closed at the bottom and terminating upwardly at a narrowed neck to an opening. The opening accommodates both a septum and a septum retaining cap. A vial holder having an inside vial containing cavity with inside dimension complementary to the outside dimension of the vial is disclosed. This vial holder is formed from elastic material such as semirigid commercially available plastics and is vertically slotted from an open top at least partially to and towards the bottom of the holder. The vial holder is provided at the open top with inwardly extending fingers which register to the outside of the narrow neck of the septum sealed vial.

Abstract: The invention relates to a cap containing a powder to be diluted in a solvent medium at the moment of utilization, and so shaped as to hermetically close a bottle containing said solvent, said cap being provided with means suitable to remove a separating septum in order to allow the powder hold in the cap to fall into the solvent and the mix therewith.

Abstract: A container is divided into two receiving chambers by a partition wall. Each chamber houses a material, such as yogurt in one and cereal flakes in the other. The container includes structural components which will create an opening in the partition wall in response to a predetermined manipulation of the outside of the container so as to enable the material contained in the two chambers to be combined in a single chamber.

Abstract: A method of utilizing an apparatus of the type comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber. The method is such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material. The method also contemplates procedures for separately refilling a dosage syringe and for relieving any residual pressure in the vial chamber with the use of an empty syringe prior to initial or final refilling of a dosage syringe.

Abstract: Combinable bottle assembly (1,6) consisting of two separately fillable bottles designed to be fitted together one above the other, can be formed inexpensively of plastic, filled and stored separately from and independently of one another and can readily be connected and tightly combined with one another to form a two-compartment container convertible to a one compartment container.The floor or bottom wall (12) of the upper bottle (1) is formed as a separate cylinder element (3) having an annular connecting plate (13) which connects a skirt wall (14) of the cylinder element to the wall (15) of a central nozzle (9) arranged concentrically therein, forming a throughflow passage (16) which is closed by a stopper (10). The lower bottle (6) comprises an elongate neck having an external screwthread (33) which is engagable with an internal thread on the elongate nozzle to permit the second bottle to be screwed into the nozzle to a connecting position to dislodge the stopper and open the containers to each other.

Abstract: A system for introducing a flowable additive (3) from a capsule (1) to paint (4), varnish, woodstain or the like in a closed (preferably lidded) container (2) (for example a paint container) modified by the provision of a relatively easily openable inlet (9) into the container. Preferably the inlet is located in a lid (6). The capsule comprises a chamber (23) which defines a volume which contains the additive. The system is provided with means (25 and 34) for creating an opening in the chamber which can communicate with the inlet and means (preferably a compressible chamber) for positively expelling additive through the opening by contracting the volume which contains the additive. The capsule and container are also provided with co-operable locating means (10 and 30 with 25) which can co-operate to assist in locating the opening created in the chamber in communication with the inlet. Also a capsule and a closed container for use in the system and a method of introducing additive using the system.

Abstract: A dispenser (1) has an admixing chamber (5) for each of the admixing components to be mixed together in a main chamber (4), the admixing chamber being inserted in a mount (7) of main chamber (4) formed by a vessel neck. A partition of the admixing chamber (5) is essentially constructed as a closure part (17), which is connected in one piece with admixing chamber (5) by means of a predetermined breaking point (18) and forms a component of a riser tube (6). For putting the discharge apparatus into operation a closure is opened and a discharge pump (3) within mount (7) is so introduced into admixing chamber (5) that the discharge pump (3) is connected with a suction connection (27) accompanied by the opening of a tube connection with riser tube (6) and then through further axial displacement of tube (6) the closure part (17) is broken free, so that the component flows from admixing chamber (5) into main chamber (4).

Abstract: The invention relates to a feeding bottle accessory wherein provision is made for the introduction into the bottle teat of material independently of and in addition to the contents of the bottle. The provision preferaly includes a syringe assembly.

Abstract: A device that can be attached to a baby bottle to facilitate the mixing of solid food particles into liquid. The shaker top comprises a circular-dome shaped mixing chamber (12) with internal screwthreads (24) on the interior wall of said chamber that are proportioned and dimensioned to accommodate the attachement of the shaker top to a baby bottle. Support wedges (34) are formed above the internal screwthreads on the inside wall of said chamber to provide a means of internally retaining a mixing disc (10). Said mixing disc is comprised of a plurality of uniformly spaced arms (20) radiating from a center post (22) which acts as a handle to ease the insertion and removal of the disc member. The arms of the mixing disc are diamond shaped to produce a multitude of shear points (40) which increase the cutting action during the shaking process.

Abstract: A method of preparing a self-curing two-component cement, which is particularly useful for the preparation of bone cement used in orthopedics, from a powder component and a liquid component. The method includes providing the powder component in a first at least partially evacuated inflexible container, providing the liquid component in a second inflexible container, and adding the liquid component to the evacuated powder component, such that the liquid floods the evacuated interspaces between the powder particles. An apparatus for carrying out this process is a syringe with a slidable piston, the syringe being sealed at its dispensing end by a removable plug. Preferably, the syringe is fitted with an axially collapsible spiral mixing device, one end of which is an elongated shaft which extends through the removable plug at the dispensing end. The elongated shaft can be rotated to homogenize the contents of the syringe, but during dispensing the mixing device collapses as the piston advances.

Abstract: A system for introducing additive (3) from a capsule (1) into a closed (preferably lidded) container (2) (for example a paint container) modified by the provision of a relatively easily openable inlet (9) into the container (2). Preferably the inlet (9) is located in a lid (6). Capsule (1) comprises a chamber (23) which contains the additive (3). The system is provided with means (25 and 34) for creating an opening in chamber (23) which can communicate with inlet (9) and means (preferably a compressibe chamber (23)) for expelling additive 3 through the opening. Capsule (1) and container (2) are also provided with co-operable locating means (10 and 24) which can co-operate to assist in locating the opening created in chamber (23) in communication with inlet 9. Also a capsule (1), a closed container (2) for use in the system and a method of introducing additive (3) using the system. Use of the system reduces the risk of spillage and splasing and is more suitable for use by inexperienced people.

Abstract: Closure caps for binary packaging systems comprising an active ingredient concentrate component and a dilutent component, which allow the user to admix the two components without coming in contact with either of them or with the resulting mixture.

Abstract: A device which can dispense a composition such as a pesticide, herbicide, fungicide, or other toxic composition into a liquid such as a solvent without exposing the composition to the atmosphere. The device comprises a jacket having a perforated top and an open bottom; a container having an open top which is sized to be removably retained within the jacket; a means for breaking a seal over the top of the container only after the container has been sealingly engaged within the jacket; a means for sealingly engaging the container and the jacket after the container has been inserted a predetermined distance into the jacket; and a graspable element coupled to the base of the container for allowing the container to be manipulated when the container is retained within the jacket.

Abstract: A closure for use with a beverage container, the closure having a plurality of compartments formed therein to store quantities of a flavoring agent separately from a mixing fluid (such as water) contained in the container. The compartments are operable by simple finger pressure to release their contents into the container one at a time for the purpose of making a flavored beverage. Support ribs are formed on the closure to allow the stacking of a number of closures or closure/container combinations without inadvertently releasing the flavoring agent from the compartments.

Abstract: This invention relates to a bottle and a method of mixing with the bottle capable of readily mixing solute or dispersoid and liquid contained in different bottles as required.This invention employs as one bottle a glass or hard plastic bottle like a Vial and as the other bottle a flexible plastic bottle, both bottles are engaged and fluctuated to mix the solute or dispersoid in the liquid.

Abstract: A container adapted to contain a number of ingredients separated until intermixture thereof is desired, consisting of a bottle having a plurality of sections each adapted to carry one of the ingredients, successive pairs of sections being separated by partitions each carrying a normally closed valve which when opened establishes communication between the associated bottle sections. The valves are individually operable manually, so that if three or more materials are to be intermixed, the order of intermixture may be controlled, and also may be closely regulated as to the degree of opening, whereby to control the rate on intermixture. A lock is also provided to prevent accidental opening of any of the valves until intermixture is desired.

Abstract: The invention relates to products useful for home laundering, and more particularly to adjustable strength bleaching compositions, highly advantageous packaging of such compositions, and a method of bleaching involving the combination of the two. More specifically, the invention concerns a highly practical and saleable laundry aid which can be used both on sensitive fabrics/dyes as an all-fabric safe oxygen bleach, and on less vulnerable fabrics/dyes as a much more effective hypohalite bleach of potency similar to that of liquid chlorine bleach. The invention is concerned with the use of an alkali metal halide activator with an oxygen bleach which is packaged in a two compartment package to keep the components separate before use.

Abstract: Two-component package, with a cup arranged in the neck of the packaging container for receiving the one component, and a sealing cap screwed to a thread of the neck and having a collar projecting into the cup, the face edge of such collar forming a butt edge for separating the cup within the zone of a rated breaking point by a screw motion of the sealing cap, characterized in that the neck (1) is designed multi-layered in a way such that an adapter ring (13) is present on the outer side of the annular wall (W) of the neck (1), such wall starting from the wall (3') of the packaging container and being stiffened by the cup (2), such adapter ring being secured against rotation on such annular wall, the outer jacket surface of such adapter ring supporting the thread (14) for the sealing cap (4) and its inner surface forcing the annular wall (W) against the jacket surface of the cup.

Abstract: A container for facilitating the manufacture, handling, shipping and storage of products to be produced by the intermixture of a plurality of ingredients, the intermixture of which for various reasons should not be performed until a time just prior to the application of other end usage thereof. The container is provided with internal partitions dividing its interior into a plurality of compartments, in each of which one of the product ingredients is initially stored for shipping and handling. The compartments are sealed from each other to prevent premature intermixture of the ingredients. Opening of the container in a prescribed manner removes the partitions to permit intermixture of the ingredients at the desired time, that is just prior to actual usage.

Abstract: The unit delimits two compartments which are intended to contain each one product and which are separated by a separating element constituted by at least one cover perforatable as a result of the manipulation of a mixing perforator. This perforator is placed into one of the compartments, so that its cutting end comes to be near the above-mentioned separating element in the storage position, and that its other end is situated opposite a deformable obturating partition of the compartment. An element for manipulating the perforator is disposed in the extension of this latter, on the other side of the partition; it is displaceable for translation to pass from the storage position to a mixing position wherein it is acting on the perforator through the partition to cause it to cut the separating element. Can be used for storing a hair dye.

Abstract: In a container for a first substance, an ampoule, which can be broken while the container is closed, is provided for a second substance. The container has a base and a rotatable cap. The ampoule spike is mounted in the region of the base. An eccentric on the cap is operatively connected to the ampoule that the base of the ampoule moves transversely to the longitudinal axis of the container on turning the cap, and the ampoule is mounted so as to be pivotable about the region of a predetermined breaking point.

Abstract: A bottle (12), which has a single circular opening (12f) at the top (12e), contains a liquid (32) in a bottom chamber (12h) and a powder (26) in an upper chamber (12d). A rubber stopper (14) exists in a neck chamber (12g) between the upper (12d) and lower (12h) chambers and isolates the liquid (32) from the powder (26). The neck chamber (12g) has a smaller cross-sectional area than the lower chamber (12h). A cylindrical basket (16) with openings in the side walls (16a) sits on top of the rubber stopper (14). A cylindrical rubber dispenser plunger (18) having a sealing portion (18a) sits above the basket (16). A locking cap (22) sits on top of the dispenser plunger (18). A septum cap (24) having vent holes (24c) sits on top of the locking cap (22 ). A sealing disc (26) sits on top of the septum cap (24). A cup-like top cap (28) covers the top of the bottle (12). Shrink wrap (32) adheres to the top cap (28) and part of the outside of the bottle (12).

Abstract: A packaging means is formed in two parts which can be assembled. The first part is constituted by two compartments comprising a first compartment or container, and a second compartment or cap surmounting the first, these two compartments being separated from each other by two diaphgrams. An intermediate part of the first part joins the two compartments. The two diaphragms are fixed to the cap which is closed at its upper portion by a stopper. The second part of this packaging means is constituted by a perforator cap capable of perforating the diaphragms when it is placed in position on the second compartment.The packaging means of this type is particularly convenient for the preservation of two products independently of each other before they are mixed for use.

Abstract: A dual-compartment container for use with two substances which must be separated prior to use and which may be combined by the single step of removing the cap from the container. A top container containing one substance is sealed along its bottom end by a membrane and is rotatably seated within a bottom container containing another substance. A container cap seals the top container prior to use and is threaded onto the bottom container. The cap is provided with a ratchet means which causes common rotation of the cap and the top container while the cap is being unthreaded from the bottom container. An annular knife member is interposed between the two containers and keyed to the top container for common rotation therewith as the cap is removed. Cam means are provided to translate rotary motion of the knife member relative to the bottom container into longitudinal motion of the knife member relative to the top container in order to pierce the sealing membrane.

Abstract: An adapter is provided in the form of a holder into which a fitment dispenser is removably received; the adapter is removably mounted on the neck of a capped container for removably suspending the dispenser within that neck. The adapter typically has frictional interfit with the dispenser which may be tubular. The container typically contains a first composition, and the fitment dispenser typically contains a second composition which is to be dispensed at the time access is gained to the first composition in the container via its neck, for use in cleaning process.

Abstract: Shake flask aerobic fermentation apparatus and systems having improved baffling and closuring are provided for improved microbial growths and increased oxygen absorption rates (OAR) approaching the levels obtainable in large-scale air-sparged fermentation vessels.

Abstract: An additional container (29) for receiving further components is arranged in the container (21) for discharging preferably polyurethane foam. The additional container (29) receives a rod (37) cooperating with an inner cover (45) sealed in said container (29). The rod is led to the outside through a packing (31) in an additional container connection connected to the bottom (20) of container (21) and is movable into container (21) for blowing off cover (45). A disk (24) inserted in a recess of container bottom (20) and fixed by its beaded edge secures a sleeve (31) penetrated by the rod (37) constructed as an axially movable plunger. The outer and inner edges (39, 40) of sleeve (31) bring about a sealing action on in each case one radial collar (38, 39) of the plunger when rod (37) is inserted, and resiliently gives way during the axial movement of the plunger.

Abstract: A combination mixing and discharge capsule for storing separate ingredients which are to be mixed together prior to use and including a container body for one ingredient closed at one end by a slidable piston and the opposite end being displaceably received in a cup-shaped cap which forms a second compartment with a perforated wall of the container body opposite the end containing the piston for receiving a frangible pillow containing a liquid second ingredient to be mixed with the ingredient in the body. The cap has a discharge nozzle extending axially therefrom and when the cap is displaced farther onto the body the innermost wall of the pillow is burst to cause the discharge of the liquid ingredient through the perforated wall end into the container body for mixing with the ingredient therein.

Abstract: A package for enabling a user to mix a diluent with a hazardous material and then fill a syringe with the solution in such a way as to substantially prevent the hazardous material from entering the immediate atmospheric environment comprising a vial and a sealed bag enclosing the entire vial so as to provide exterior sealed containment for the vial in the event of unexpected failure of the vial container and elastomeric stopper assembly to sealingly contain the hazardous material. The vial is sealed within the bag so as to form a space exteriorly of the vial which is controlled by the bag and which is operable to receive any hazardous material in the form of aerosol or droplets that may pass outwardly through the elastomeric stopper assembly as a result of the withdrawal of the syringe needle therefrom and the increased interior gas pressure created within the vial container by the injection of diluent therein.

Abstract: A container comprises a bottle for a liquid product and having at the end of its neck a leakproof envelope enclosing an additional product to be stored separately from the liquid in the bottle. A cap on the neck includes a slidable push button carrying a perforator to open the envelope in a central region of the envelope to allow the additional product to mix with the liquid and then to be discharged through an eccentric duct in the cap rather than having to pass through the center of the cap where the perforator is positioned.

Abstract: A container for holding contents as two separate components which can be mixed together later. The container comprises a cup positioned in a neck of the container for receiving a first of the components; a screwcap coordinated with the neck of the container and having a collar extending into the cup, a front edge of said collar forming a strike edge for separating the cup in the region of a line of intended breakage upon a further screwing on of the screwcap beyond a basic position for storage; and a wall of the cup has an annular step, and the strike edge of the collar comes flush on the annular step on the wall of the cup, the step--forming the place of intended breakage--being located at a distance above the bottom of the cup, there being a bead extending towards an outer surface of the collar and projecting inwardly from the inner surface of the wall of the cup, the step lying below said bead; and a clip shoulder is disposed on the collar and engages the bead of the cup wall.

Abstract: A stoppered vial containing a medicament is secured through the edge of a flexible container. Mixing of the medicament in the vial with the contents of the flexible container is accomplished by removing the stopper from the vial by manipulation through the sides of the flexible container. In one embodiment, the stoppered vial is mounted through and in the edge of the flexible container and in another embodiment the flexible container has a port which will receive the stoppered vial therein in a secure manner.

Abstract: A two-component package comprises a cup arranged in a neck of the package to receive one component, and a screw cap. The cup defines an intended break line and cooperates with the neck of the package. A collar which extends into the cup, defines an abutment edge at the front end thereof. The abutment edge is disposed for separating the cup in the region of said break line upon a screwing of the cap.The cup defines a cup wall and an annular step therein.The step includes the break line spaced above the bottom of the cup.An inner surface of the cup wall has a bead inwardly directed therefrom. The bead disposed above the annular step engages against an outer surface of the collar.

Abstract: A mixing and dispensing receptacle including a first container defining a first nozzle portion and a first sealed chamber retaining a first substance and a rupturable wall portion separating the first chamber from the interior of the first nozzle portion; and a second container defining a second chamber retaining a second substance and a second nozzle portion disposed at least partially within the interior of the first nozzle portion and circumferentially sealed thereto so as to sealingly isolate the second substance. The second nozzle portion is movable axially relative to the first nozzle portion so as to pierce the rupturable wall portion and provide communication between the first and second chambers. One of the nozzle portions comprises a tapered outer surface adapted for engagement with a mating coupling member and an aseptic shield covers the tapered outer surface and is removable therefrom.

Abstract: A package comprising a tube of flexible material having a first and second end, a first ultrasonic seal extending transversely across the tube and closing said first end, a second ultrasonic seal extending transversely across the tube and closing said second end, a chamber formed by said tube and end seals for containing contents, a hollow stem extending through and supported by the second seal with an inner end inside the chamber and an outer end outside the chamber, and a removable seal closing the outer end of the stem, said stem seal being removable when it is desired to dispense the contents from the package.

Abstract: Apparatus and method for testing the sufficiency of sterilization includes a test tube having a distal end in which a bacterial spore element is disposed. A sealed glass ampule containing a sterile liquid culture medium is disposed in the test tube and a plunger having a fenestration closed with a hydrophobic filter is fitted slidingly in the open end of the test tube. In use, the apparatus is exposed to sterilization, and thereafter the plunger is pushed down into the test tube to engage the ampule to slide the latter into engagement with an ampule-engaging means to thereby fracture or break the ampule so that the contents of the ampule are released into the test tube to contact the spore element, whereby the apparatus is then subjected to incubation, the sufficiency of the sterilization being thereby determined.

Abstract: A cartridge comprising a threaded cap connected with one end of a first hollow cylinder the other end of which abuts a closing bottom piece, said parts being held together by a second outer cylinder with a top flange in conjunction with fastening and sealing organs inserted between the inner surface of the outer cylinder and the outer surfaces of the first cylinder and the bottom piece, said organs being dimensioned and shaped in such a manner that they permit the rigidly held opposing parts to be moved relative to each other when the cap is screwed down on a suitably threaded neck part until a predetermined gap between the flange and the top of the cap is closed.