Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

Abstract: An optical measurement device includes: an optical sensor that detects pulsed signal light and that outputs a detection signal formed of an exponential-function response; an A/D converter that samples the detection signal output from the optical sensor and that converts the detection signal into a digital signal; and a processor comprising hardware, the processor being configured to subject the digital signal output from the A/D converter to inverse transformation by using a multiple diagonal matrix, thus calculating an estimated pulse of the signal light.

Abstract: Devices and methods for super-resolution optical microscopy are described. Devices include an optical multiplexer to develop an excitation/illumination optical beam that includes alternating pulses of different profiles. Devices also include a signal processing unit to process a sample response to excitation/illumination beam and to subtract the neighboring pulses of the different profiles from one another on a pulse-to-pulse basis. Devices can be incorporated in existing confocal microscopy designs. As the subtraction effectively reduces the volume of the response signal, the spatial resolution of the systems can be markedly improved as compared to previously known optical microscopy approaches.

Abstract: A portable imaging apparatus and system. A sample processing device has a reaction chamber configured to receive a sample and react the sample with a fluorescent compound that emits a specified wavelength of light when excited by light within an excitation band. An illumination source can be positioned to illuminate the reaction chamber when the sample processing device is positioned for imaging. A light guide can be positioned to face the reaction chamber and transfer the emitted light to an imaging detector. The light guide has a filter that blocks the wavelength of light from the illumination source and passes the fluorescent emitted light. The light guide unit defines an angular light acceptance range and is configured to constrain angular spreading of light.

Abstract: A method for imaging a sample with charged particles comprises directing charged particles towards the sample along a primary axis, and simultaneously detecting a first portion and a second portion of the charged particles transmitted through the sample with a first detector and a second detector, respectively. The second detector is positioned downstream of the first detector. Each of the transmitted charged particles exits the sample at an exit angle between a direction of the transmitted charged particle and the primary axis. The exit angles of the first portion of the transmitted charged particles overlap with the exit angles of the second portion of the transmitted charged particles. In this way, complimentary information, such as the structural and compositional information, may be obtained simultaneously.

Abstract: Apparatus and methods for performing optical analyses in a harsh environment are disclosed. Some of the systems and methods of the present disclosure include fluorescence, absorption, and reflectance detection using a drum spectrometer. Other systems and methods of the present disclosure include a measurement channel and a parallel reference channel concurrently filtering optical signals.

Abstract: Structures and techniques are provided for shaping or steering a light field for an optical biological parameter sensor such that the light is partially or wholly collimated and enters a person's skin at an oblique angle to the person's skin such that the light has a direction component oriented towards or away from a photodetector of the optical biological parameter sensor.

Abstract: An evaluation method of a silicon epitaxial wafer, including using a photoluminescence (PL) measuring apparatus to measure a PL spectrum of the mirror wafer and adjusting the apparatus so emission intensity of a TO-line becomes 30000 to 50000 counts, irradiating the silicon epitaxial wafer with an electron beam, measuring PL spectrum from an electron beam irradiation region, and sorting out and accepting a silicon epitaxial wafer which has emission intensity resulting from a CiCs defect of the PL spectrum being 0.83% or less of the emission intensity of the TO-line and from a CiOi defect being 6.5% or less of the emission intensity of the TO-line.

Abstract: A method for enhancing illumination intensity of an image according to an embodiment of the present disclosure may include receiving an image, determining a filter application scheme by using a neural network model trained to enhance the illumination intensity of the image, and outputting an image having enhanced illumination intensity by applying, to the image, the determined filter application scheme. The neural network model trained using machine learning includes a first group of layers for extracting feature information of the image, a second group of layers for determining a type of filter based on the extracted feature information, and a third group of layers for determining the optimal parameter for the filter based on the extracted feature information. The neural network model may be provided through an external server in an IoT environment using a 5G network.

Abstract: An assembly, for example an electrostatic chuck assembly, includes a first member, a second member disposed proximate the first member, a bond layer disposed between the first member and the second member, and at least one optical sensor disposed proximate the bond layer to detect a temperature of the bond layer in a field of view of the at least one optical sensor. The bond layer includes a phosphorescent material and provides a dual function of bonding the second member to the first member and emitting phosphorescent radiation towards the at least one optical sensor. In one form, the first member is an electrostatic chuck member and the second member is a heating plate. The assembly may further include a cooling plate and an additional bond layer disposed between the heating plate and the cooling plate.

Abstract: An endoscope system includes a correction-value calculating unit that calculates a correction value of data to be used for calculation of the biological information or the like; an index-value calculating unit that calculates one type of index value or a plurality of types of index values to be used as a determination reference for determining whether, for example, the correction value is to be calculated; a determination unit that determines, by using the one type of index value or the plurality of types of index values, whether an endoscope image is appropriate for correction; and a correction unit that, if the determination unit determines that the endoscope image is appropriate for correction, corrects the endoscope image, the biological information, or the data by using the correction value calculated by using the endoscope image that has been determined to be appropriate for correction.

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

Abstract: An endoscope system includes a correction-value calculating unit that calculates a correction value of data to be used for calculation of biological information; an index-value calculating unit that calculates one type of index value or a plurality of types of index values to be used as a determination reference for determining whether the correction value is to be calculated or whether the correction value is to be used; a display unit that displays the one type of index value or the plurality of types of index values; an input unit that inputs an instruction for calculating the correction value or an instruction for executing correction by using the correction value; and a correction unit that, if the correction-value calculating unit calculates the correction value in response to the instruction for calculating the correction value or if the instruction for executing correction is issued, executes correction by using the correction value.

Abstract: A solution for controlling mildew in a cultivated area is described. The solution can include a set of ultraviolet sources that are configured to emit ultraviolet and/or blue-ultraviolet radiation to harm mildew present on a plant or ground surface. A set of sensors can be utilized to acquire plant data for at least one plant surface of a plant, which can be processed to determine a presence of mildew on the at least one plant surface. Additional features can be included to further affect the growth environment for the plant. A feedback process can be implemented to improve one or more aspects of the growth environment.

Abstract: In the present technology, the timing at which suction is performed is optimized in order to enhance the microparticle separation performance in a technology for separating target microparticles in a microchip. For this purpose, the present technology provides a method of optimizing a microparticle suction condition, and the like, using a microchip having a main flow channel through which a liquid containing a microparticle flows, a microparticle suction flow channel arranged coaxially with the main flow channel, and a branch flow channel branching from the main flow channel. The method includes: a branch point specifying process of specifying a branch point at which the branch flow channel branches from the main flow channel; and a time assignment process of assigning a time T1 to be applied to suction of the microparticle.

Abstract: The present disclosure provides methods for applying artificial neural networks to flow cytometry data generated from biological samples to diagnose and characterize cancer in a subject. The disclosure also provides methods of training, testing, and validating artificial neural networks.

Abstract: A method for performing a surgical procedure includes planning a resection of a bone of a patient. A volume of the bone is removed according to the planned resection using a surgical tool. As the bone is removed, data corresponding to a shape and volume of the removed bone is tracked with a computer system operatively coupled to the surgical tool. A prosthesis is implanted onto the bone of the patient based on the tracked data corresponding to the shape of the removed bone.

Abstract: A light emitting assembly comprising a solid state device, when and if coupleable with a power supply constructed and arranged to power the solid state device to emit from the solid state device a first wavelength radiation, and an enveloping vessel enhancing the luminescence of the solid-state device and providing a mechanism for arranging luminophoric medium in receiving relationship to said first, radiation, and which in exposure to said first radiation, is excited to responsively emit second wavelength radiation or to otherwise transfer its energy without radiation to a third radiative component. In a specific embodiment, monochromatic blue or UV light output from a light-emitting diode is converted to achromatic light without hue by packaging the diode with fluorescent organic and/or inorganic fluorescers and phosphors on the walls of the solid-state light envelope which keeps the diode and the fluorescers and phosphors under a vacuum or a rare or Noble gas.

Abstract: A bidirectional reflectance distribution function (BRDF) measurement system is provided that measures the BRDF across many photonic bands such as the UV, Vis, NIR, SWIR, MWIR, and LWIR (scale) simultaneously (speed) in an innovative measurement system. The measurement system includes an illuminating optical system, a detection system, and a calibration reference. The illuminating optical system directs illuminating light to an imaging location and the detection system detects returning light from the imaging location. The calibration reference including an optical metamaterial having a receiving surface. The calibration reference is placed at the imaging location and alters illuminating light incident on the receiving surface to produce returning light having known optical properties.

Abstract: A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

Abstract: A photoresist with a detection additive is utilized to help increase the contrast of images during an after development inspection process. The detection additive fluoresces during the after development inspection process and adds to the energy that is reflected during the after development inspection process, increasing the contrast during the after development inspection process and helping to identify defects that are not otherwise detectable.

Abstract: A frequency conversion device, including a source of a pump beam of electromagnetic radiation of a first wavelength, and an array of mutually spaced semiconductor islands including at least one III-V semiconductor compound and configured so that the pump beam of electromagnetic radiation of the first wavelength incident upon the semiconductor islands and electromagnetic radiation of a second wavelength incident upon the semiconductor islands cause the semiconductor islands to emit electromagnetic radiation of a third wavelength different to the first and second wavelengths by at least one of a sum frequency generation process and a difference frequency generation process, wherein the semiconductor islands are supported by a transparent support such that the support is substantially transparent to radiation of the third wavelength, wherein at least the radiation of the third wavelength passes through the transparent support.

Abstract: An optical particle sensor comprises at least first and second light sources of different wavelength for sequential operation. An optical detector is used to detect light from the light sources emitted or scattered by particles to be sensed. A current injection compensation signal is also provided which is dependent on which light source of the optical arrangement is in use. The compensation signal means the amplifier does not need to re-settle in response to different background illumination levels associated with the different light sources. In this way, detection signals may be obtained in quick succession from different light sources.

Abstract: A molecular detection device is related. The device includes a carrier, a detector and a control computer. The carrier includes a substrate, a middle layer and a metal layer. The middle layer is sandwiched between the substrate and the middle layer. The detector is configured to detect molecules on a surface of the carrier. The control computer is connected to the detector and configured to analyze a detection result. The middle layer includes a base and a patterned bulge on the base, and the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge.

Abstract: The present disclosure provides a portable device and method for controlling an alcoholic beverage through an at least partially transparent container. The method includes acquiring a fluorescence spectrum of the beverage through a wall of the container, normalizing a profile of a measured spectrum according to the maximum intensity of a reference spectrum, calculating a resemblance factor between the measured spectrum and the reference spectrum, and determining if the beverage is genuine according to the obtained value of the resemblance factor.

Abstract: The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale.

Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

Abstract: A rapid sensing value estimation circuit and a method thereof are provided. The rapid sensing value estimation circuit includes a first sensing unit, an integration sensing circuit and a rapid estimation circuit. The rapid estimation circuit includes a clock generator, a second counter, a first digital comparator, and an arithmetic module. The clock generator generates a clock signal. The second counter counts the clock signal to generate a second count value. The first digital comparator determines whether the second count value exceeds a first predetermined count value when the first count value increases. The arithmetic module estimates the first count value at an end of an integration time according to a ratio of the second maximum count value to the second count value and the first count value when the second count value exceeding the first predetermined count value, to generate an estimated count value result.

Abstract: A light sheet microscope includes an illumination optical system configured to generate a light sheet in an intermediate image space. A transport optical system, which is telecentric on both sides, is configured to image the light sheet generated in the intermediate image space into a sample and to image a region of the sample illuminated by the light sheet as an intermediate image into the intermediate image space. A detection optical system is configured to image the intermediate image generated in the intermediate image space onto a detector. The optical axes of the illumination optical system, the transport optical system and the detection optical system intersect one another in the intermediate image space. The microscope further includes a scanning element, which is arranged in the transport optical system and through which the light sheet is moveable in the sample transversely to the optical axis of the transport optical system.

Abstract: A laser beam profile measurement device includes: a plate-like or block-like fluorescence generation element including an incidence surface on which a laser light is incident and an emission surface from which the laser light is emitted; a light separation element for separating fluorescence from the laser light, the fluorescence generated in the fluorescence generation element and emitted from the emission surface; and an image element for receiving the fluorescence. The fluorescence generation element includes a first film formed on the incidence surface thereof. The first film has a wavelength-to-reflectance characteristic of transmitting a wavelength ?1 of the laser light and reflecting a wavelength ?2 of the fluorescence. The first film has a wavelength-to-reflectance characteristic of transmitting a wavelength ?1 of the laser light and reflecting a wavelength ?2 of the fluorescence.

Abstract: An evaluation method of a silicon wafer allows non-destructive and non-contact inspection of a slip that affects the electrical properties of semiconductor devices, without being subjected to restrictions of the surface condition of silicon wafers or processing contents as much as possible. The evaluation method of a silicon wafer includes a step of section analysis where a surface of a single crystal silicon wafer after thermal processing is divided by equally-spaced lines into sections with an area of 1 mm2 or more and 25 mm2 or less and the existence of strain in each of the sections is determined based on a depolarization value of polarized infrared light, and a screening step where the wafer is evaluated as non-defective when the number of adjacent sections being determined to have strain by the section analysis step does not exceed a predetermined threshold value.

Abstract: A spectrometer may include a radiation source having a spark generator, an entrance slit, a dispersive element and a plurality of detectors, and a rotatable sector shutter having an axis of rotation and a trigger unit optically coupled to the sector diaphragm. The axis of rotation of the sector shutter is non-parallel to a connecting line between the source and the entrance slit.

Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.

Abstract: A microscopy system has a detection system, which is configured to detect light of a first channel in a detection region and convert it to a first fluorescent light signal, to detect light of a second channel in a second detection region and convert it to a first correction signal, and to detect light of a third channel in a third detection region and convert it to a second correction signal. The system further includes a controller, which is configured to determine an approximation value for the spatial distribution of the concentration of the fluorescent dye in an object region using the first fluorescent light signal, the first correction signal, and the second correction signal. A first part of the emission spectrum of the fluorescent dye is detected in the first detection region.

Abstract: Provided are methods of preparing a sample for detection by placing the sample on a shrinkable scaffold and then shrinking the scaffold. An exemplary shrinkable scaffold is a thermoplastic substrate.

Abstract: The current invention relates to the task of masking, i.e. determination of boundaries in an image of biological particles and/or elements or parts of biological particles in image cytometry. Methods for masking of a biological particle or element or region of a biological particle in a sample are provided which include staining a first element or region of the biological particle with a first fluorescent dye, staining a second element or region of the biological particle with a second fluorescent dye, recording an image of the fluorescent light signal emitted from the sample, and determining boundaries of the biological particle or element or region of the biological particle based on the fluorescent light signal in the image.

Abstract: An ultraviolet light-emitting phosphor having excellent degradation resistance and emission intensity is provided. The ultraviolet light-emitting phosphor is a phosphor comprising yttrium element, scandium element, aluminum element and oxygen element, which is excited by irradiation of vacuum ultraviolet rays or electron beams to emit ultraviolet rays.

Abstract: An apparatus for testing a wiring circuit includes: a circuit substrate having wirings in the circuit substrate and pads on an upper surface of the circuit substrate and connected to the wirings; an electrode below a lower surface of the circuit substrate; an optical sensor above the upper surface of the circuit substrate and configured to detect a signal emitted from the upper surface of the circuit substrate; and an optical unit above the optical sensor and configured to irradiate light, wherein the optical sensor includes: an optical substrate whose optical characteristics are changed by the signal emitted from the upper surface of the circuit substrate; and a patterned reflective layer on a surface of the optical substrate facing the circuit substrate, the patterned reflective layer having a first region reflecting light incident on the optical substrate and a second region transmitting the light incident on the optical substrate.

Abstract: An optical device for a biological or chemical sensor includes: an absorption cavity configured to receive a biological or chemical medium; an injection waveguide to inject an analysis light beam into the absorption cavity; and an extraction waveguide to extract a measurement light beam, corresponding to the analysis light beam after transit through the absorption cavity. The absorption cavity has a shape of a right cylinder with an elliptical base. One end of the injection waveguide is placed at a first focus of the ellipse and one and of the extraction waveguide is placed at a second focus of the ellipse. A core of the injection waveguide and a core of the extraction waveguide each have a tip-shaped end, with a constant height in a plane parallel to the generatrix of the right cylinder and a tip-shaped cross section in planes parallel to the base of the right cylinder.

Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.

Abstract: An oral care evaluation process may include: illuminating soft oral tissue within an oral cavity with a light source emitting a spectrum of light which induces fluorescence in an organic compound; generating image data for an image of the soft oral tissue while illuminating the soft oral tissue, the image comprising a plurality of pixels; and evaluating oral hygiene using a programmable processor programmed to assess an attribute of each pixel of the image.

Abstract: A system for generating a light pulse causes fluorescence in an object. The system includes a light emitting diode (“LED”) light source to emit light onto the object. The light source has an operational radiant flux. The system also includes an imaging sensor to sense light emitted due to fluorescence in the object. The system further includes a controller electrically coupled to the light source. The controller is able to drive the light source to produce a pulse of light at a pulse radiant flux. The controller is also able to inhibit the light source after the pulse for a darkness period. The pulse radiant flux of the light produced by the light source is higher than the operational radiant flux of the light source.

Abstract: A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, a sample stage supported on the primary optical support element to support a sample, a return optical system to receive returned light from a sample and transmit returned light to a detection apparatus, wherein the return optical system is mounted on the primary optical support element, and wherein the compact microscope include a at least one of the following elements; a) an objective lens system, b) a temperature-control system, and c) the return optical system being operable to separate returned light into at least a first wavelength band and a second wavelength band.

Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.

Abstract: In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.

Abstract: A method of fluorescence calibration. An excitation light is provided and incident on an object through an optical probe. The fluorescence light generated from the object is detected. Structural data of the object is acquired, and an optical attenuation property of the object is calculated based on the structural data. The fluorescence intensity is then calibrated based on the optical attenuation property.

Abstract: A light detection device comprises: a flow path section in which a plurality of lines of flow of a plurality of droplets 4 dispersed in oil and moving along a linear line of flow is retained on an array plane; a laser beam irradiation section which introduces a laser beam 3 in a direction in which the plurality of lines of flow are arrayed in the flow path section to irradiate the plurality of lines of flow; and a light detection section which detects emitted light generated from the plurality of lines of flow by the irradiation of the laser beam, from a vertical direction with respect to the array plane. A refractive index of the oil no and a refractive index of the droplets nd have a difference such that ?0.02?nd?no?0.05.

Abstract: Disclosed is an optical fiber overheat detection testing apparatus including an optical fiber having a first end and a second end, the optical fiber having a predetermined length associated with a predetermined attenuation based on an overheat detection instrument loop. The apparatus includes a first interrupt disposed equidistant between the first end and the second end defining a first half of the optical fiber and a second half of the optical fiber, the first half and the second half having equal length, the first interrupt having a first actuator operable by a first electric current to attenuate light wave traversal of the optical fiber. The apparatus includes a second interrupt disposed on the first half and spaced from the first end at least six tenths of a meter, the second interrupt having a second actuator operable by a second electric current to attenuate light wave traversal of the optical fiber.

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract: A portable imaging system. The imaging system uses perpendicular beams, both low level laser beams at TEM00 Mode and infrared laser beams all beams at a different level, to separate multipliers to provide bodily Fourier Transformed analog signals, gain, and then separate filters to improve signal quality, and a charge-coupled Device (CCD) to convert the analog signals to digital signals. These separate signal sets are then stored, and a program converts the signals to a rotatable, section capable translucent digital image. The imaging medium for the process may be low concentration Indocyanine Green Dye.