Boron Containing Patents (Class 252/400.4)
  • Patent number: 11634748
    Abstract: Methods are provided for the epigenetic analysis of cell-free DNA using organic boranes to convert oxidized 5-methylcytosine residues in the cell-free DNA to dihydrouracil (DHU) residues. Cell-free DNA is contacted with an organic borane selected to successively bring about reduction, deamination, and decarboxylation of oxidized 5-methylcytosine residues such as 5-carboxymethylcytosine and 5-formylcytosine, resulting in DHU residues in place thereof. Following amplification, the treated cell-free DNA is sequenced, with the DHU residues read as thymine residues. Reaction mixtures, kits and additional methods are also provided, as are related methods for the epigenetic analysis of DNA, including cell-free DNA.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: April 25, 2023
    Assignee: CLEARNOTE HEALTH, INC.
    Inventors: Patrick A. Arensdorf, Damek Spacek
  • Patent number: 8951719
    Abstract: The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and kits comprising compositions of the invention.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: February 10, 2015
    Assignee: Gentegra, LLC.
    Inventors: Michael Hogan, Michael Saghbini, David Wong, Chunnian Shi
  • Publication number: 20120308987
    Abstract: The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and kits comprising compositions of the invention.
    Type: Application
    Filed: August 20, 2012
    Publication date: December 6, 2012
    Applicant: GenVault Corporation
    Inventors: Michael HOGAN, Michael SAGHBINI, Chunnian SHI, David WONG
  • Patent number: 8277549
    Abstract: The present invention provides a water-based ink for ink-jet recording containing a coloring agent, water, and a water-soluble organic solvent. The coloring agent contains a dye represented by the following general formula (1). The ink further includes a boron compound and at least one of amino polycarboxylic acid and amino polycarboxylate.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 2, 2012
    Assignee: Brother Kogyo Kabushiki Kaisha
    Inventor: Taro Nagano
  • Patent number: 8221797
    Abstract: This invention discloses a wood preservative composition for the supplemental or remedial treatment of in-service poles, posts, piling, cross ties and other wooden structures. The wood preservative composition comprises copper 8-hydroxyquinolate (oxine copper) in combination with a boron compound or a fluoride compound.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: July 17, 2012
    Assignee: Osmose, Inc.
    Inventors: Jun Zhang, Douglas J. Herdman, Richard J. Ziobro
  • Patent number: 8106200
    Abstract: The present invention relates to new borane complexes with substituted pyridines, a process for the synthesis of new borane complexes with substituted pyridines, solutions comprising new borane complexes with substituted pyridines and a method of using new borane complexes with substituted pyridines for organic reactions.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: January 31, 2012
    Assignee: BASF SE
    Inventor: Elizabeth Burkhardt
  • Publication number: 20100248363
    Abstract: The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and kits comprising compositions of the invention.
    Type: Application
    Filed: September 14, 2009
    Publication date: September 30, 2010
    Applicant: GENVAULT CORPORATION
    Inventors: Michael Hogan, Michael Saghbini, David Wong, Chunnian Shi
  • Publication number: 20100104756
    Abstract: The present invention provides a water-based ink for ink-jet recording containing a coloring agent, water, and a water-soluble organic solvent. The coloring agent contains a dye represented by the following general formula (1). The ink further includes a boron compound and at least one of amino polycarboxylic acid and amino polycarboxylate.
    Type: Application
    Filed: October 29, 2009
    Publication date: April 29, 2010
    Applicant: BROTHER KOGYO KABUSHIKI KAISHA
    Inventor: Taro NAGANO
  • Patent number: 7052630
    Abstract: In this application is disclosed a resin additive composition which can by produced by precipitating a calix(n+m+l)arene represented by the following general formula (2) and in a dissolved state together with or at the same time at least one functional ingredient selected from the group consisting of various water-soluble or hydrophilic resin flam-retardants, resin thermal stabilizers and resin curing agents, and in a dissolved or suspended state. This resin additive composition has a good affinity for organic polymers such as polyolefin and the like, which allows the functional ingredient(s) to be dispersed homogeneously in the resin. Therefore are provided high-performance resin compositions comprising various functional ingredient(s).
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: May 30, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Wu Yang, Hajime Kambara, Mika Osawa, Yoko Ueno, Masayuki Okoshi
  • Patent number: 6593485
    Abstract: The invention relates to a stabilizer composition comprising at least one processing stabilizer selected from special phosphite, mono- and diphosphonite compounds, at least one acid scavenger selected from the group consisting of selected metal stearates, hydrotalcites, oxides, hydroxides of alkaline earth metals, at least one UV stabilizer selected from compounds containing at least one 2,2,6,6-tetraalkylpiperidinyl-group and optionally at least one sterically hindered phenolic antioxidant. A further subject matter of the invention is a solid masterbatch composition or a liquid concentrate comprising above-mentioned stabilizer composition. The invention relates also to a process for stabilizing polymeric materials selected from the group consisting of special polyolefins comprising adding to the polymeric material a stabilizing quantity of said stabilizing composition.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: July 15, 2003
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Klaus Stoll, Andreas Thuermer, Rainer Wolf