Liquid Encapsulation Utilizing An Emulsion Or Dispersion To Form A Solid-walled Microcapsule (includes Liposome) Patents (Class 264/4.1)
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Patent number: 10364280Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERTX4AX6WEIX10X11LPNLX16X17X18QX20GAFIX25X26LHD. The present disclosure also relates to the use of such a PD-L1 binding polypeptide a prognostic and/or diagnostic agent as well as a therapeutic agent.Type: GrantFiled: October 28, 2016Date of Patent: July 30, 2019Assignee: AFFIBODY ABInventor: Elisabet Wahlberg
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Patent number: 10342830Abstract: This document provides methods and materials for treating lung conditions induced by inhalable insulin therapy. For example, compositions including a dried amnion tissue preparation and/or a dried stem cell preparation as well as methods for using such compositions to treat inhalable insulin induced lung conditions are provided.Type: GrantFiled: December 30, 2015Date of Patent: July 9, 2019Inventor: Gary M. Petrucci
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Patent number: 10322191Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.Type: GrantFiled: July 18, 2017Date of Patent: June 18, 2019Assignee: TARVEDA THERAPEUTICS, INC.Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
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Patent number: 10314946Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.Type: GrantFiled: February 7, 2018Date of Patent: June 11, 2019Assignee: Yeda Research and Development Co. Ltd.Inventors: Jacob Klein, Ronit Goldberg, Noa Iuster, Raya Sorkin
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Patent number: 10307490Abstract: Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.Type: GrantFiled: May 23, 2013Date of Patent: June 4, 2019Assignee: The Ohio State UniversityInventors: Robert J. Lee, Young Bok Lee, Deog Joong Kim, Chang Ho Ahn
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Patent number: 10308682Abstract: Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. This unprecedented mechanism of “self-assembly to interfere with self-organization” allows inhibition of the growth of cancer cells.Type: GrantFiled: March 6, 2014Date of Patent: June 4, 2019Assignee: Brandeis UniversityInventors: Bing Xu, Yi Kuang
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Patent number: 10301506Abstract: A process for preparing polymer. An embodiment of a method includes generating a resin solution including a first reaction solvent and a polymer resin dissolved therein; deploying the resin solution into a precipitation solvent contained in a chamber of a reaction vessel, wherein deploying the resin solution includes generating droplets of the resin solution; disturbing a resulting mixture of the resin solution and the precipitation solvent, wherein the mixture produces a precipitate; and generating a polymer powder from the mixture, including isolating the precipitate from a remaining portion of the mixture, and drying the isolated precipitate.Type: GrantFiled: August 26, 2016Date of Patent: May 28, 2019Assignee: Cymer-Dayton, LLCInventors: Limor Ben-Asher, David Edward Noga, Zhongliang Zhu, Anderson Bouton
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Patent number: 10285405Abstract: The present disclosure provides a particulate matter comprising particles carrying an essentially dry combination of components comprising at least one natural oil and at least one surfactant, the components being selected such that upon contact with water, oil in water emulsion is formed. In particular, the emulsion formed is a stable emulsion, with stability of at least several hours, as observed by the lack of phase separation during that time.Type: GrantFiled: April 10, 2014Date of Patent: May 14, 2019Assignee: Nobactra Israel Ltd.Inventor: Giora Kritzman
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Patent number: 10273267Abstract: ?-Hairpin peptidomimetics of the general formula cyclo(-Xaa1-Xaa2-Thr3-Xaa4-Ser5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-) and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa4, Xaa6, Xaa7, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12 and Xaa13 being amino acid residues of certain types which are defined in the description and the claims, have elastase inhibitory properties, especially against human neutrophil elastase, and can be used for preventing infections or diseases related to such infections in healthy individuals or for slowing infections in infected patients. The compounds of the invention can further be used where cancer, or immunological diseases, or pulmonary diseases, or cardiovascular diseases, or neurodegenerative diseases, or inflammation, or diseases related to inflammation, are mediated or resulting from elastase activity. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.Type: GrantFiled: December 27, 2013Date of Patent: April 30, 2019Assignee: POLYPHOR AGInventors: Frank Otto Gombert, Daniel Obrecht, Odile Sellier-Kessler, Alexander Lederer, Christian Ludin, Manuella Schmitt-Billet, Steffen Weinbrenner
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Patent number: 10258570Abstract: The invention relates to liposomes for pulmonary application, advantageously comprising at least one first and at least one second phospholipid, cholesterol, and at least one active substance and/or colorant, wherein the first phospholipid is a phosphatidylcholine, preferably DSPC, and the second phospholipid is a phosphatidylcholine or an ethanolamine, preferably selected from the group DMPC, DPPC, DPPE. It is thereby advantageous if the first and the second phospholipid are present at a molar ratio of 0.5:1 to 10:1, preferably at a ratio of 6:1 to 2:1, in particular preferably at a ratio of 3:1. It is further advantageous if the molar ratio between phospholipids and cholesterol is between 10:1 and 1:1, preferably between 6:1 and 3:1, in particular preferably 4:1. The second phospholipid is further preferably DMPC or DPPE, in particular preferably DPPE. The size of the liposomes is advantageously between 0.05 ?m and 5 ?m, preferably between 0.2 ?m and 2.Type: GrantFiled: June 29, 2010Date of Patent: April 16, 2019Assignee: Lung Biotechnology Inc.Inventors: Tobias Gessler, Thomas Schmehl, Monika Rieger
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Patent number: 10241045Abstract: Spectrally encoded microbeads and methods and devices for making and using spectrally encoded microbeads are provided. The disclosed methods and devices facilitate the preparation and use of microbeads containing multiple lanthanide nanoparticles, which microbeads have uniquely identifiable spectral codes. The disclosed microbeads, and the methods and devices for making and using same, find use in multiplexing and high-throughput biomarker analysis.Type: GrantFiled: August 22, 2013Date of Patent: March 26, 2019Assignee: The Regents of the University of CaliforniaInventors: Brian Cullen Baxter, Joseph L. Derisi, Polly M. Fordyce, Rachel E. Gerver, Rafael Gòmez-Sjöberg, Brett A. Helms, Kurt S. Thorn, Ronald N. Zuckermann
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Patent number: 10232013Abstract: The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a method for treating a breast cancer, particularly triple negative breast cancer (TNBC) with TP4.Type: GrantFiled: January 11, 2017Date of Patent: March 19, 2019Assignee: Academia SinicaInventors: Jyh-Yih Chen, Chen-Hung Ting
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Patent number: 10220095Abstract: The present invention relates to pharmaceutical compositions comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically acceptable salt thereof, at least one monovalent counterion donor or a pharmaceutically acceptable salt thereof, and an amphipathic therapeutic agent or a derivative or pharmaceutically acceptable salt thereof. The present invention also relates to methods of inhibiting cancer cell growth while reducing toxicity, comprising administering the pharmaceutical composition described herein.Type: GrantFiled: May 31, 2017Date of Patent: March 5, 2019Assignees: TAIWAN LIPOSOME COMPANY, LTD, TLC BIOPHARMACEUTICALS, INCInventors: Pei Kan, Yun-Long Tseng, Han-Chun Ou, Chun-yen Lai
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Patent number: 10214704Abstract: A lubricating oil comprises a base oil; and an anti-degradation additive comprising microcapsules, nanocapsules, or a combination comprising at least one of the foregoing; the microcapsules and the nanocapsules each independently having a core of a neutralizing material and a polymeric encapsulant configured to release the neutralizing material in an acidic environment by breaking crosslinks or hydrogen bonds in the polymeric encapsulant. The released neutralizing material can prevent the formation of viscous, high molecular weight molecules thus enhancing the lifetime of the lubricating oil and improving its reliability.Type: GrantFiled: April 6, 2017Date of Patent: February 26, 2019Assignee: BAKER HUGHES, A GE COMPANY, LLCInventors: Darryl Ventura, Rostyslav Dolog, Oleg A. Mazyar, Valery Khabashesku, Qusai Darugar
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Patent number: 10206272Abstract: The present invention relates to a method for manufacturing a tracer-encapsulated solid pellet for magnetic-confinement fusion, the method comprising a liquid droplet formation step of discharging an organic liquid containing an organic solvent into a stabilizing liquid to thereby form liquid droplets 12, and an organic solvent removal step of removing the organic solvent from the liquid droplets 12A. The organic liquid to be used is a liquid having a first organic polymer containing tracer atoms and a second organic polymer being an organic polymer different from the first organic polymer dissolved in the organic solvent, wherein the first organic polymer and the second organic polymer can be mutually phase-separated.Type: GrantFiled: May 15, 2015Date of Patent: February 12, 2019Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Nakahiro Satoh, Ryo Yoshimura, Masaru Takagi, Toshiyuki Kawashima, Hirofumi Kan
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Patent number: 10201508Abstract: A method of producing positively charged liposome vesicles for use as carriers of lipophilic molecules. A mixture of hydrogenated phospholipids, a cationic excipient and a lipophilic molecule are dissolved in a solvent to form a composition. The composition is dried to remove the solvent. The dried composition is hydrated to form liposome vesicles and optionally the liposome vesicles are homogenized to form smaller vesicles. The vesicles are useful for delivery lipophilic molecules, such as, but limited to, lutein and zeaxanthin, to ocular tissues using iontophoresis.Type: GrantFiled: February 14, 2017Date of Patent: February 12, 2019Assignee: KEMIN INDUSTRIES, INC.Inventor: Diogo de Sousa Martins
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Patent number: 10195577Abstract: A process for producing microcapsules containing a shell and a core of a liquid water-insoluble material is disclosed. The microcapsules are prepared using a bifunctional isocyanate, an anionically modified diisocyanate, a bifunctional amine, and a protective colloid. The protective colloid is a polyvinyl alcohol copolymer having hydrolysis degrees from 85 to 99.9%.Type: GrantFiled: April 27, 2015Date of Patent: February 5, 2019Assignee: BASF SEInventors: Ewelina Burakowska-Meise, Wolfgang Denuell, Ulrich Issberner
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Patent number: 10189875Abstract: Provided are a peptide consisting of the amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof, and the use thereof. Cancer can be effectively prevented or treated by application of the peptide.Type: GrantFiled: July 22, 2016Date of Patent: January 29, 2019Assignee: ENSOL BIOSCIENCES INC.Inventors: Hae Jin Kim, Duk Soon Hwang, Eun Joung Moon
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Patent number: 10190208Abstract: Methods for obtaining a profile for a batch, or lot, of a precursor material and using the profile while processing the precursor material to form a polymer are disclosed. In such a method, a process profile that corresponds to the characteristics of a particular precursor material (e.g., the batch, etc.) may be generated. That process profile may then be used to cause a material processing system to process the precursor material in a manner that accounts for differences between that precursor material and a “standard” precursor material, while providing a polymer and, optionally, a film of “standard” quality. Apparatuses and systems that are configured to obtain profile data for a batch of precursor material, generate or modify a process profile based on the profile data and use the process profile to form a polymer are also disclosed.Type: GrantFiled: May 9, 2016Date of Patent: January 29, 2019Assignee: HZO, INC.Inventor: James D. Dempster
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Patent number: 10188699Abstract: Administration of compositions comprising cell-permeable cancer-specific proliferating cell nuclear antigen derived peptides and their variants reduces the proliferation of cancer cells and also augments cytotoxic effects of chemotherapeutics. The compositions are effective in cells harboring mutations in DNA repair proteins.Type: GrantFiled: November 17, 2016Date of Patent: January 29, 2019Inventors: Robert J. Hickey, Linda H. Malkas
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Patent number: 10179106Abstract: The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.Type: GrantFiled: May 10, 2012Date of Patent: January 15, 2019Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventor: Saul Yedgar
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Patent number: 10173192Abstract: A quad-centric nozzle and system for hydrocapsule encapsulation is disclosed. In at least one embodiment, a quad-centric nozzle is disclosed for encapsulating discrete droplets of liquid by generating a continuous coating or layer of a polymerizable liquid which is substantially immiscible with the core liquid. In at least one embodiment, the quad-centric nozzle includes: a material feed port assembly, a polymer feed port assembly, a first water feed port assembly, a second water feed port assembly and an encapsulated material exit port assembly. In at least one embodiment, the quad-centric nozzle is configured for use in a system for hydrocapsule encapsulation having a pressure control system, a water control system and sparging column, and an ultraviolet exposure chamber system.Type: GrantFiled: June 12, 2017Date of Patent: January 8, 2019Inventors: Michael Pitsokos, Ara Manukian, William Toreki
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Patent number: 10167316Abstract: Provided are a peptide consisting of the amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof, and the use thereof. Cancer can be effectively prevented or treated by application of the peptide.Type: GrantFiled: July 22, 2016Date of Patent: January 1, 2019Assignee: ENSOL BIOSCIENCES INC.Inventors: Hae JIn Kim, Duk Soon Hwang, Eun Joung Moon
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Patent number: 10166220Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.Type: GrantFiled: December 2, 2015Date of Patent: January 1, 2019Assignee: ADARE PHARMACEUTICALS S.R.L.Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
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Patent number: 10154968Abstract: Stable nanoparticle compositions comprising buprenorphine and at least one biodegradable polymer. The disclosure also provides methods of controlling pain in an animal and methods of treating addiction in a human utilizing the stable nanoparticle compositions, as well as pharmaceutical formulations comprising the stable nanoparticle compositions. The stable nanoparticle compositions are capable of releasing buprenorphine over several days, weeks, or months following administration. The stable nanoparticle compositions of buprenorphine utilize biodegradable polymers capable of degrading into non-toxic components in the body of an animal and may be excreted in the urine of the animal following their metabolism in the body. The stable nanoparticle compositions can advantageously provide sustained release of buprenorphine in the body after a single administration without the need for surgical removal of implanted matrices subsequent to depletion of the drug.Type: GrantFiled: February 9, 2017Date of Patent: December 18, 2018Assignee: AUBURN UNIVERSITYInventors: William R. Ravis, Yuh-Jing Lin
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Patent number: 10137079Abstract: Described is a transdermal ethosome composition for the treatment of pain. The transdermal ethosome composition comprises: an alcohol; a phospholipid; water; and a magnesium salt, a TRPV1 receptor agonist, or both a magnesium salt and a TRPV1 receptor agonist. The present compositions can be used to treat pain that is muscular, nociceptive or neuropathic in origin.Type: GrantFiled: February 20, 2014Date of Patent: November 27, 2018Assignee: CURA HEALTH INC.Inventor: Moheb Maalawy
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Patent number: 10137089Abstract: Embodiments may also include a system for reducing a solvent concentration in a plurality of microparticles. The system may include a solvent extraction tank. In the solvent extraction tank, a mixture including the plurality of microparticles and the solvent may be contacted with water to form an aqueous suspension. A first portion of the solvent may dissolve into the water of the aqueous suspension to reduce the solvent concentration in the plurality of microparticles. The system may also include a concentration unit in fluid communication with the solvent extraction tank. The concentration unit may further reduce the solvent concentration in the plurality of microparticles. A microparticle concentrate may be formed. The system may further include a washing unit. In the washing unit, the microparticle concentrate may be contacted with a washing solution and may form an amalgam of washed particles.Type: GrantFiled: November 21, 2016Date of Patent: November 27, 2018Assignee: Rezolute, IncInventor: Greg Bryden Sebring
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Patent number: 10111853Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.Type: GrantFiled: December 13, 2016Date of Patent: October 30, 2018Assignee: PLACON THERAPEUTICS, INC.Inventors: Mark T. Bilodeau, Craig A. Dunbar, Timothy E. Barder, Edward R. Lee, Rossitza G. Alargova, Danielle N. Rockwood, Rajesh Shinde, Patrick Lim Soo, Benoît Moreau
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Patent number: 10098841Abstract: Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further contains (d) a tertiary amine as a component of the membrane. Also provided is a method of inducing a phase transition of a bilayer membrane vesicle, the method including the step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having the property of accumulating at an interface to the bilayer membrane vesicle. By causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion.Type: GrantFiled: April 25, 2013Date of Patent: October 16, 2018Assignee: Japan Science and Technology AgencyInventor: Munetaka Kunishima
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Patent number: 10092486Abstract: Poiyurea or polyurethane capsule compositions. A subset of these compositions contain a plurality of capsules and a capsule formation aid, in which each of the capsules contains a poiyurea or polyurethane wall and an oil core; the poiyurea or polyurethane wall is formed of a reaction product of a polyisocyanate and a cross-linking agent in the presence of the capsule formation aid; and the oil core contains an active material. The polyisocyante, cross-linking agent, and capsule formation aids are described herein. Also disclosed are methods of preparing poiyurea and polyurethane capsule compositions, as well as consumer products containing one of these compositions.Type: GrantFiled: August 15, 2014Date of Patent: October 9, 2018Assignee: INTERNATIONAL FLAVORS & FRAGRANCES INC.Inventors: Yabin Lei, Li Xu, Lewis Michael Popplewell
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Patent number: 10092515Abstract: The present invention provides an intravenous liposomal formulation of a low dose polymyxin B or a pharmaceutical composition thereof. The present invention also provides methods utilizing the intravenous liposomal formulation or its pharmaceutical composition for increasing the therapeutic efficacy during treatment of a bacterial infection in a subject, for decreasing exposure of renal tissue to the polymyxin B during a course of polymyxin B treatment and for lowering exposure to polymyxin B in renal tissues in a subject receiving polymyxin B treatment.Type: GrantFiled: November 20, 2017Date of Patent: October 9, 2018Assignee: University of Houston SystemInventors: Vincent Tam, Diana Chow, Jie Gohlke
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Patent number: 10087230Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.Type: GrantFiled: September 16, 2016Date of Patent: October 2, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Maria R. Parkhurst, Richard A. Morgan, Steven A. Rosenberg, Shannon Faith Rosati
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Patent number: 10064976Abstract: A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.Type: GrantFiled: February 10, 2017Date of Patent: September 4, 2018Assignee: Beta-O2 Technologies Ltd.Inventors: Uriel Barkai, Avi Rotem, Yehezkel Bremer, Tova Neufeld
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Patent number: 10059740Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.Type: GrantFiled: May 26, 2016Date of Patent: August 28, 2018Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Lori Hazlehurst, Mark McLaughlin, Priyesh Jain, William S. Dalton
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Patent number: 10052303Abstract: The present invention provides stable, fast-acting liposomal and micelle formulations of cannabinoids that are suitable for pharmaceutical and nutraceutical applications.Type: GrantFiled: August 3, 2015Date of Patent: August 21, 2018Assignee: TEEWINOT TECHNOLOGIES LIMITEDInventor: Robert Winnicki
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Patent number: 10041129Abstract: This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of chemokines, cytotoxic genes, and/or dendritic cell genes.Type: GrantFiled: June 2, 2016Date of Patent: August 7, 2018Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: James J. Mulé, Domenico Coppola, Timothy J. Yeatman, Andrey Loboda, Michael V. Nebozhyn
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Patent number: 10039715Abstract: The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.Type: GrantFiled: August 31, 2016Date of Patent: August 7, 2018Assignee: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.Inventors: Vincenzo Cerundolo, Simon Eastman
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Patent number: 10035338Abstract: A method of adhering first and second elongate webs includes depositing a first component of a two-component adhesive on a first face of the first elongate web and depositing a second component of the two-component adhesive on a first face of the second elongate web. The first face of the first elongate web and the first face of second elongate web are brought into contact, and the two components are mixed ultrasonically. In an alternate method, a two-component adhesive on at least a first face of the first elongate web, with at least one of the two components micro-encapsulated so that the two components of the two-component adhesive do not react. The first face of the first elongate web and the first face of the second elongate web are brought into contact. Ultrasound and/or heat is applied to free the microencapsulated components of the two-component adhesive, so that the components of the two component adhesive can react.Type: GrantFiled: June 19, 2014Date of Patent: July 31, 2018Assignee: MARK ANDY, INC.Inventor: John Bailey Howard
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Patent number: 10028912Abstract: Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.Type: GrantFiled: October 15, 2012Date of Patent: July 24, 2018Assignee: CELATOR PHARMACEUTICALS, INC.Inventors: Donna Cabral-Lilly, Lawrence Mayer, Paul Tardi, David Watkins, Yi Zeng
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Patent number: 10022326Abstract: Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti-tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.Type: GrantFiled: July 17, 2013Date of Patent: July 17, 2018Assignee: Onyx Therapeutics, Inc.Inventors: Katherine A. Chu, Elena T. Chan, Ying Fang, Mouhannad Jamaa, Christopher Justin Kirk, Tony Muchamuel, Zhengping Wang, Jing Jiang, Jeffrey Joseph Jones
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Patent number: 10022365Abstract: A liposome of irinotecan or irinotecan hydrochloride and its preparation method are disclosed. The liposome contains irinotecan or irinotecan hydrochloride, neutral phospholipid and cholesterol, wherein the weight ratio of the cholesterol to the neutral phospholipid is 1:3 to 1:5. The liposome is prepared by an ion gradient method.Type: GrantFiled: March 21, 2017Date of Patent: July 17, 2018Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.Inventors: Xinyong Tong, Guofeng Lei, Chengxia Yu, Liang Chen
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Patent number: 10017570Abstract: The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of signal transduction and activator of transciption3 (STAT3) and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases.Type: GrantFiled: February 27, 2013Date of Patent: July 10, 2018Assignees: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC), KOREA BASIC SCIENCE INSTITUTEInventors: Hak-Sung Kim, Joong-Jae Lee, Jung Min Choi, Eun-Kyeong Jo, Chul-Su Yang, Hae-Kap Cheong, Hyun Jung Kim
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Patent number: 10010848Abstract: This device comprises a hollow body, the hollow body defining: an internal conduit for distributing the first fluid, the internal conduit defining an inner volume; an external conduit or distributing the second fluid, the internal conduit and the external conduit extending coaxially along a longitudinal axis (AA?). It at least comprises one metal tube extending along the longitudinal axis (AA?) and being positioned in the inner volume of the internal conduit and/or in the downstream extension of the internal conduit and/or of the external conduit.Type: GrantFiled: October 17, 2014Date of Patent: July 3, 2018Assignee: CAPSUMInventors: Mathieu Goutayer, Yan Eric Pafumi, Javier Angel Tesan
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Patent number: 9999700Abstract: Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are composed of (a) a polyanion in the absence of a polycation, wherein the polyanion comprises at least one crosslinking group capable of covalently crosslinking with itself, and (b) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate. The adhesives have numerous medical and non-medical applications.Type: GrantFiled: March 11, 2016Date of Patent: June 19, 2018Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventor: Russell J. Stewart
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Patent number: 9993519Abstract: The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of NF-?B which is overexpressed specifically in cancer stem cells present in tumors.Type: GrantFiled: March 3, 2016Date of Patent: June 12, 2018Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.Inventors: Yoon Jeong Park, Chong-Pyoung Chung, Jue-Yeon Lee, Jin Sook Suh
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Patent number: 9988420Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.Type: GrantFiled: December 17, 2014Date of Patent: June 5, 2018Assignee: Novartis AGInventors: Bernhard Hubert Geierstanger, Jan Grunewald, Weijia Ou, Tetsuo Uno, Yongqin Wan, Xing Wang, Yunho Jin
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Patent number: 9980908Abstract: It is intended to provide a liposome preparation which is a liposome, has a lipid bilayer membrane composed of an inner membrane constituted by a lipid including one or more types of functional lipids (a lipid capable of chemically interacting with another compound such as a charged lipid, a polarizable lipid, a lipid-soluble lipid or a water-soluble lipid) and an outer membrane constituted by a lipid with or without including one or more types of functional lipids, and is characterized in that at least a condition that the amount of any one type of functional lipid contained in the inner membrane is larger than in the outer membrane is satisfied. The liposome preparation is suitable as a liposome for encapsulating a contrast agent (a neutral substance having a hydroxy group), siRNA (an anionic substance) having an anticancer activity or the like. Its encapsulation ratio of drug agents, dispersion stability, control release and the like have been improved.Type: GrantFiled: January 16, 2015Date of Patent: May 29, 2018Assignee: KONICA MINOLTA, INC.Inventor: Takeshi Isoda
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Patent number: 9968758Abstract: Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway.Type: GrantFiled: March 20, 2015Date of Patent: May 15, 2018Assignee: Boston Scientific Scimed, Inc.Inventors: Paul Smith, Robert B. Devries, Jason Weiner, Man Minh Nguyen, Gary J. Leanna, Kevin John Wilcox, Javier Palomar-Moreno, Fergal Horgan, Martyn G. Folan, Patricia Kelly, Michael G. Hayes, Sean P. Fleury
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Patent number: 9969771Abstract: Provided are a tetrapeptide for inhibiting VEGF-induced angiogenesis and a use thereof, and particularly, provided is a peptide having the amino acid sequence of R-X1-X2-E (wherein X1 is leucine (L), isoleucine (I) or valine (V), and X2 is tyrosine (Y) or phenylalanine (F)) for inhibiting angiogenesis, or preventing, improving or treating cancer. This research was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MSIP), Republic of Korea, in 2011 and 2013 [NRF-2011-0028790 and 2013M3A9B6046563]. The tetrapeptide may effectively inhibit VEGF-induced angiogenesis or growth of cancer cells without a risk of side effects, and therefore may be expected to exhibit an excellent anticancer effect.Type: GrantFiled: July 28, 2016Date of Patent: May 15, 2018Assignee: AVIXGEN INC.Inventors: Young Myeong Kim, Yi Yong Baek, Dong Keon Lee, Jun-Sub Choi, Min Jung Kim, Hye Cheong Koo
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Patent number: 9968555Abstract: Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.Type: GrantFiled: February 11, 2015Date of Patent: May 15, 2018Assignee: ARADIGM CORPORATIONInventors: David C. Cipolla, Igor Gonda