Solid-walled Microcapsule Formed By Physically Removing A Constituent (e.g., Evaporation, Extraction, Etc.) Patents (Class 264/4.6)
  • Patent number: 10968379
    Abstract: A heat-storage composition includes a resin and a heat storage material. The composition has a viscosity of 100 to 1,000 dPa·s, as measured with a cylinder-type rotational viscometer. The composition also has a storage elastic modulus (G?) of 3 Pa or more at an angular frequency of 1 rad/s, as measured by a dynamic viscoelasticity measurement method at a temperature of 25° C. and at a strain of 0.1%.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 6, 2021
    Assignee: DIC Corporation
    Inventors: Yuko Koseki, Kenichi Fujisaki, Junichirou Koike, Kyouichi Toyomura
  • Patent number: 10821080
    Abstract: The present disclosure relates to processes for preparing microparticles using an emulsion process where both a solvent and a salt are used in the continuous phase of the emulsion. The present disclosure also relates to microparticles having an angle of repose of ?35, as measured using a Hele-Shaw cell.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: November 3, 2020
    Assignee: Evonik Corporation
    Inventors: Adrian Raiche, Jason Campbell, Heather Nettles, Allison Womack
  • Patent number: 10485762
    Abstract: Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 26, 2019
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Trevor Petrel, Craig Bartling, Lena Furci, Carrie Howland
  • Patent number: 10441674
    Abstract: The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 15, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Hans Christian Hedrich, Joris Hoefinghoff
  • Patent number: 10435735
    Abstract: Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: October 8, 2019
    Assignee: DNA GENOTEK INC.
    Inventors: Hyman Chaim Birnboim, Lindsay Pozza, Carlos Alberto Merino Hernandez, Evgueni Vladimirovitch Doukhanine
  • Patent number: 9987202
    Abstract: Provided is a solid anhydrous composition that comprises particles comprising a core containing at least one beneficial agent and an envelope surrounding the core. The envelope comprises at least one hydrophobically modified polysaccharide and at least one water-soluble carbohydrate and/or water-soluble polyol. The particles simultaneously have a poured powder density ranging from 300.0 g/l to 600.0 g/l and an absolute density of greater than 1.0. The envelope also comprises at least one structuring agent. Also provided is a cosmetic process for caring for and/or for the hygiene of and/or for conditioning and/or for fragrancing and/or for making up keratin material. The process comprises applying to the keratin material the above composition. Also provided is a cosmetic process for treating body odor and optionally human perspiration, which comprises applying to a keratin material a composition defined above comprising at least one deodorant and/or antiperspirant in free form and/or in encapsulated form.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 5, 2018
    Assignee: L'OREAL
    Inventors: Gérard Malle, Tiina Luukas, Didier Laverre, Isabelle Bara
  • Patent number: 9962342
    Abstract: The present invention provides a pharmaceutical composition containing Guaifenesin. The invention pharmaceutical composition comprises a core containing Guaifenesin and a coating layer encapsulating the core containing Guaifenesin, and the coating layer comprises a plasticizer and a polymer, wherein the polymer is applied in the range of approximately 5 wt. % to 35 wt. % based on the total weight of the pharmaceutical composition. A method for controlled releasing an expectorant agent is also provided in the present invention.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 8, 2018
    Assignee: SUNNY PHARMTECH INC.
    Inventors: Hao-Hsiang Hung, Chia-Ching Ting
  • Patent number: 9820940
    Abstract: The present invention provides novel liposomal formulations of polymyxin B and pharmaceutical compositions thereof useful for the treatment of bacterial infections. The liposomal formulation comprises a lipid component formed as vesicles each having a minimum size of at least 500 nm and polymyxin B encapsulated in the vesicles. The present invention also provides a drug delivery system that comprises a plurality of liposomes encapsulating a polymyxin B therein, where the liposomes have a minimum vesicular size of at least 500 nm. The liposomes comprising the drug delivery system are useful to increase efficacy of a treatment for a bacterial infection by increasing bioavailability and distribution of the polymyxin B within the subject.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: November 21, 2017
    Assignee: University of Houston System
    Inventors: Vincent Tam, Diana Chow, Jie He
  • Patent number: 9821274
    Abstract: A hybrid diafiltration system includes an intermediate tank, a feed pump and a single-pass concentration (SPC) module, feed and product flow diverting valves to affect a multi-step concentration, wash and final-concentration process with fewer recirculation passes than conventional systems.
    Type: Grant
    Filed: February 7, 2015
    Date of Patent: November 21, 2017
    Assignee: SPF INNOVATIONS LLC
    Inventors: Gaston de los Reyes, Leon Mir
  • Patent number: 9789064
    Abstract: Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticizer has been incorporated and which contain a drug of pharmaceutical interested within them.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: October 17, 2017
    Assignee: GP PHARM, S.A.
    Inventors: Antonio Parente Dueña, Josep Garcés Garcés, Angel Bonilla Muñoz, David Cunillera Colomé
  • Patent number: 9782334
    Abstract: Systems and methods for skin rejuvenation are disclosed herein. In an embodiment, a skin rejuvenation system includes a unit dose of a booster product that includes active ingredients of ferulic acid and phloretin; a unit dose of at least one exfoliating product that includes active ingredients of ferulic acid and phloretin in combination with fruit acids or alpha hydroxyacids; and a unit dose of a nano-additive product for enhancing penetration of the active ingredients. A method for skin rejuvenation includes applying topically, to a skin surface to be treated, a booster product including active ingredients of ferulic acid and phloretin; applying topically, to the skin surface, at least one exfoliating product including active ingredients of ferulic acid and phloretin in combination with one of fruit acids or alpha hydroxyacids; and applying topically, to the skin surface, a nano-additive product for enhancing penetration of the active ingredients.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: October 10, 2017
    Inventors: Gabriel Serrano Sanmiguel, Juan Manuel Serrano Nunez, Joaquin Melendez Zamora
  • Patent number: 9775907
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: October 3, 2017
    Assignee: MATINAS BIOPHARMA NANOTECHNOLOGIES, INC.
    Inventors: Raphael Mannino, Ruying Lu
  • Patent number: 9526761
    Abstract: The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 27, 2016
    Assignee: SCIL Technology GmbH
    Inventors: Klaus Hellerbrand, Andreas Schuetz, Rainer Sigl
  • Patent number: 9005494
    Abstract: Prior art processes for producing protein-based capsules (for example, capsules for use in electrophoretic media) tend to be wasteful because they produce many capsules outside the desired size range, which is typically about 20 to 50 ?m. Capsule size distribution and yields can be improved by either (a) emulsifying a water-immiscible phase in a preformed coacervate of the protein; or (b) using a limited coalescence process with colloidal alumina as the surface-active particulate material.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: April 14, 2015
    Assignee: E Ink Corporation
    Inventors: Peter J. Valianatos, Rajesh Chebiyam, Jeremy J. Manning, Michael L. Steiner, Thomas H. Whitesides, Michael D. Walls
  • Patent number: 8932714
    Abstract: A method for controlling a particle diameter and a particle diameter distribution of emulsion particles during manufacturing of an emulsion dispersion is provided. The method includes causing two or more types of liquids substantially immiscible with each other to continuously and sequentially pass through net bodies. The net bodies are disposed in a cylindrical flow passage at intervals of 5 to 200 mm, and the number of the net bodies is more than 50 and 200 or less. Each of the net bodies is equivalent to a gauze having a mesh number of 35 mesh to 4000 mesh in accordance with an ASTM standard and has a surface that intersects the direction of the flow passage. An emulsification apparatus used for the method includes a feed pump for feeding two or more types of liquids substantially immiscible with each other; and a cylindrical flow passage to which the two or more types of liquids fed by the feed pump are delivered.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: January 13, 2015
    Assignee: Nippon Oil Corporation
    Inventors: Toshikatsu Shoko, Yasuo Togami, Akira Takagi, Hideko Hayashi
  • Publication number: 20140356445
    Abstract: The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive capabilities. A therapeutically relevant platform comprising artificial constructs are contemplated comprising numerous soluble and surface bound Treg cell stimulating factors that may induce tolerance following allograft transplantation. Such artificial constructs, being the size of a cell, have surface bound monoclonal antibodies specific to regulatory T-cell surface moieties and encapsulated soluble regulatory T-cell modulating factors.
    Type: Application
    Filed: July 16, 2014
    Publication date: December 4, 2014
    Inventor: Steven R. Little
  • Patent number: 8889044
    Abstract: The present invention relates to a method for producing mesoporous silica particles including a silica-containing outer shell portion with a mesoporous structure. The method includes the steps of: (I) pressurizing a mixed solution containing a hydrophobic organic compound, a surfactant, and an aqueous solvent by a high-pressure emulsification method so as to form an emulsion that includes emulsion droplets containing the hydrophobic organic compound; (II) adding a silica source to the emulsion so as to form a silica-containing outer shell portion with a mesoporous structure on a surface of the emulsion droplets, and precipitating composite silica particles including the outer shell portion and the emulsion droplets on an inner side relative to the outer shell portion; and (III) removing the emulsion droplets from the composite silica particles.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: November 18, 2014
    Assignee: Kao Corporation
    Inventors: Toshihiro Yano, Masaki Komatsu, Hiroji Hosokawa, Jun Yoshida
  • Patent number: 8852644
    Abstract: The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Instillo GmbH
    Inventors: Bernd Baumstuemmler, Bernd Penth, Felix Penth, Akif Emre Tuereli
  • Publication number: 20140232029
    Abstract: The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 21, 2014
    Applicants: Baxter International Inc., Baxter Healthcare SA
    Inventors: Katalin Varadi, Peter Turecek, Brigitte Keil, Sylvia Peyrer-Heimstaett, Hans-Peter Schwarz
  • Patent number: 8722097
    Abstract: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: May 13, 2014
    Assignee: Allergan, Inc.
    Inventors: James Chang, Patrick Hughes, Chin-Ming Chang
  • Patent number: 8715545
    Abstract: The present systems and methods utilize a polyamic acid solution as a precursor to form a polyimide bead having desired properties. The polyamic acid solution may be formed into a polyamic acid droplet. The polyamic acid droplet is then processed to form a polyamic acid bead, such as by extraction of solvent to concentrate the polyamic acid or by partial chemical imidization of the polyamic acid. The polyamic acid bead is then better able to retain its shape during subsequent processing steps, such as drying and pressurizing, before final thermal imidization.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: May 6, 2014
    Assignee: ExxonMobil Upstream Research Company
    Inventors: Dennis G. Peiffer, Barbara Carstensen, Richard S. Polizzotti, Arnold Lustiger, David C. Dalrymple, Walter T. Matuszek
  • Patent number: 8715740
    Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: May 6, 2014
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, David L. Kaplan
  • Patent number: 8697131
    Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: April 15, 2014
    Assignee: Instillo GmbH
    Inventors: Akif Emre Tuereli, Bernd Penth, Peter Langguth, Bernd Baumstuemmler
  • Publication number: 20140017376
    Abstract: Processes for the preparation of bio-based fiber gums and products produced by these processes and some of their uses.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 16, 2014
    Applicant: The United States of America, as represented by the Secretary of Agriculture
    Inventor: The United States of America, as represented by the Secretary of Agriculture
  • Patent number: 8628851
    Abstract: The invention provides a method for encapsulating a liquid, which method comprises the steps of providing a suspension of droplets of the liquid to be encapsulated; stabilizing the suspension of droplets with a surfactant; adding a layered inorganic material to the stabilized suspension; and subjecting the suspension to a treatment which establishes that a shell of a hybrid material is formed around the droplets, which hybrid material comprises at least part of the inorganic material and at least part of the surfactant. The invention further provides encapsulated liquid droplets obtainable by said method.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: January 14, 2014
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Sabine Fischer, Hartmut Rudolf Fischer, Jacobus Eversdijk, Renz Jeroen Van Ee
  • Publication number: 20130316008
    Abstract: The present invention provides a method for forming a multicompartmentalized vesicular structure comprising an outer block copolymer vesicle and at least one inner block copolymer vesicle, wherein the at least one inner block copolymer vesicle is encapsulated inside the outer block copolymer vesicle. The method comprises forming the at least one inner block copolymer vesicle by any method and adding block copolymers dissolved in a suitable solvent to a dispersion of the at least one inner block copolymer vesicle in an aqueous buffer under conditions that allow the block copolymers to form the outer block copolymer vesicle and encapsulate the at least one inner block copolymer vesicle. A multicompartmentalized vesicular structure and its uses are also provided.
    Type: Application
    Filed: August 4, 2011
    Publication date: November 28, 2013
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Madhavan Nallani, Nikodem Tomczak, Zhikang Fu, Mirjam Ochsner
  • Publication number: 20130266661
    Abstract: The present invention relates to an amphiphilic cyclic phosphazene trimer which is biocompatible and a method for preparing the same. The present invention also relates to pharmaceutical formulations of hydrophobic drugs that are micelle-encapsulated by the amphiphilic cyclic phosphazene trimer and a method for preparing the same.
    Type: Application
    Filed: December 16, 2011
    Publication date: October 10, 2013
    Applicant: CNPHARM CO., LTD.
    Inventors: Youn Soo Sohn, Yong Joo Jun
  • Publication number: 20130259922
    Abstract: The present invention relates to the preparation of liposomes with enhanced loading capacity for pharmaceutically and/or diagnostically active agents and/or cosmetic agents which are substantially solubilized by the liposomal membranes, to liposome dispersions with enhanced stability with respect to release of the active agent and/or cosmetic agent from the liposomes obtainable by the process, and to pharmaceutical or cosmetic compositions comprising said stabilized liposome dispersions. The preparation may involve dehydration and rehydration steps of liposome dispersions which may be carried out by spray drying.
    Type: Application
    Filed: May 20, 2011
    Publication date: October 3, 2013
    Applicant: MEDIGENE AG
    Inventors: Heinrich Haas, Ursula Fattler
  • Publication number: 20130209548
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: August 15, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130209547
    Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.
    Type: Application
    Filed: March 6, 2013
    Publication date: August 15, 2013
    Applicant: PACIRA PHARMACEUTICALS INC.
    Inventor: PACIRA PHARMACEUTICALS INC
  • Publication number: 20130195965
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: August 1, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130183372
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130183373
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 18, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130183375
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 18, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130177634
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177635
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177637
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177636
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: Pacira Pharmaceuticals, Inc.
    Inventor: Pacira Pharmaceuticals, Inc.
  • Publication number: 20130177638
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Publication number: 20130177633
    Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: PACIRA PHARMACEUTICALS, INC.
    Inventor: PACIRA PHARMACEUTICALS, INC.
  • Patent number: 8465778
    Abstract: Biocompatible intraocular microspheres include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the microspheres can be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The microspheres can be placed into an eye to treat or reduce the occurrence of one or more ocular conditions.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: June 18, 2013
    Assignee: Allergan, Inc.
    Inventors: Patrick M. Hughes, Christian Sarrazin, Elisabeth Rossi, Michèle Boix
  • Publication number: 20130071480
    Abstract: Particles having a core based on at least one biodegradable organosoluble polymer. At least a part of the surface of the particles is coated with at least one hyaluronan or a derivative thereof, the hyaluronan being a water-soluble, amphiphilic hyaluronan of which the carboxylic functions are in part transformed to form hydrophobic groups.
    Type: Application
    Filed: November 13, 2012
    Publication date: March 21, 2013
    Applicant: Centre National De La Recherche Scientifique
    Inventor: Centre National De La Recherche Scientifique
  • Patent number: 8343773
    Abstract: The invention provides a microcapsule array comprising a plurality of microcapsules immobilized on a surface, optionally in microwells in said surface. Each of the microcapsules comprises an outer layer or shell defining a microcapsule interior, said outer layer having a permeability towards a nanoscale species which is dependent on an environmental condition to which said array is exposed.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 1, 2013
    Assignee: Agency for Science, Technology and Research
    Inventors: Maxim V. Kiryukhin, Maria N. Antipina, Karen Chong, Hong Yee Low, Gleb B. Sukhorukov
  • Publication number: 20120308825
    Abstract: Nano-fibrous microspheres and methods for forming them are disclosed herein. In one embodiment the microsphere includes a plurality of nano-fibers aggregated together in a spherical shape; and a plurality of pores formed between at least some of the plurality of nano-fibers. The nano-fibers are formed of star-shaped polymers.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 6, 2012
    Inventors: Peter X. Ma, Xiaohua Liu
  • Publication number: 20120309621
    Abstract: The invention relates to compositions including an encapsulated triazinyl sulfonylurea. The invention further relates to methods for controlling weeds. The invention additionally provides methods for producing such compositions.
    Type: Application
    Filed: April 5, 2012
    Publication date: December 6, 2012
    Applicant: ARYSTA LIFESCIENCE NORTH AMERICA, LLC
    Inventor: JAMES C. LEE
  • Publication number: 20120256336
    Abstract: The present invention relates to a method for producing mesoporous silica particles including a silica-containing outer shell portion with a mesoporous structure. The method includes the steps of: (I) pressurizing a mixed solution containing a hydrophobic organic compound, a surfactant, and an aqueous solvent by a high-pressure emulsification method so as to form an emulsion that includes emulsion droplets containing the hydrophobic organic compound; (II) adding a silica source to the emulsion so as to form a silica-containing outer shell portion with a mesoporous structure on a surface of the emulsion droplets, and precipitating composite silica particles including the outer shell portion and the emulsion droplets on an inner side relative to the outer shell portion; and (III) removing the emulsion droplets from the composite silica particles.
    Type: Application
    Filed: December 14, 2010
    Publication date: October 11, 2012
    Applicant: Kao Corporation
    Inventors: Toshihiro Yano, Masaki Komatsu, Hiroji Hosokawa, Jun Yoshida
  • Patent number: 8282990
    Abstract: Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose -regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero -order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: October 9, 2012
    Assignee: Dong-A Pharmaceutical, Co., Ltd.
    Inventors: Hyun Hee Kwak, Ghun II Lee, Yong Man Park, Mi Kyung Son, Hi Chang Yang, Tae Hyoung Kim, Yoon Ji Kim, Byong Moon Kim, Sung Hee Lee, Soo Hyung Kang, Moohi Yoo
  • Patent number: 8246868
    Abstract: A W/O emulsion is produced from an aqueous solution containing a substance to be entrapped in a vesicle in a dissolved or suspended state and an oil phase containing an emulsifier; subsequently, the W/O emulsion is cooled to a temperature at which the aqueous solution of the W/O emulsion becomes a frozen particle and the oil phase maintains a liquid state, and the oil phase is removed; thereafter, an oil phase containing a vesicle constituent lipid is added to the frozen particle, and the obtained mixture is then stirred, so as to substitute the emulsifier on the surface of the frozen particle with the vesicle constituent lipid; and thereafter, an external Water phase is added to the frozen particle coated with a lipid membrane, so as to hydrate the lipid membrane by the external water phase. This process achieves a high entrapment yield of a desired substance while controlling desired physical properties such as particle diameter.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: August 21, 2012
    Assignee: University of Tsukuba
    Inventors: Sosaku Ichikawa, Takashi Kuroiwa
  • Patent number: 8206621
    Abstract: A plasticized polymer of PLGA employing ethanol as the plasticizing agent prepared at a temperature higher than the Tg and lower than the boiling point of ethanol can be used in subcutaneous implants containing active ingredients therein.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: June 26, 2012
    Assignee: Mediolanum Pharmaceuticals Ltd.
    Inventors: Patrice Mauriac, Pierre Marion
  • Publication number: 20120153520
    Abstract: The invention discloses the synthesis of a new-type chitosan-based hybrid macromolecule and a method for producing or using the macromolecule. This macromolecule comprises an amphiphatic chitosan and a silicon-based coupling agent that is anchored by a chemical bonding. The method for producing the hybrid macromolecule can be easily operated under ambient environment. The produced macromolecule can be self-assembled in an aqueous environment to form a nanocarrier, and has the ability to efficiently encapsulate drugs for a subsequent sustained release purpose. This self-assembled hybrid nanocarrier demonstrated features of excellent biocompatibility, drug loading ability and cellular uptake efficiency.
    Type: Application
    Filed: May 5, 2011
    Publication date: June 21, 2012
    Inventors: Dean-Mo LIU, Tsan-Hua Tung, Hongwei Cheng