Encapsulating Normally Liquid Material Patents (Class 264/4)
  • Publication number: 20150086613
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Application
    Filed: March 29, 2013
    Publication date: March 26, 2015
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20150079290
    Abstract: The disclosure provides a poly(urea-formaldehyde) microcapsule, which comprises encapsulated in the poly(urea-formaldehyde) microcapsule an organofluorine silane of the general formula (I) A3C(CA2)xSiR1yX(3-y) (I), wherein in formula (I) A is either fluorine (F) or hydrogen (H), wherein at least 50% of atoms A are fluorine. X is chloro or a group RO, wherein R is a linear or branched alkyl radical of 1 to 4 carbon atoms, R1 is a linear, branched or cyclic alkyl group of 1 to 8 carbon atoms, n=0 or 2, y=0 or 1 or 2 and m=0 to 20, encapsulated within the microcapsule. The disclosure also provides self-healing coating compositions comprising such polymeric microcapsules and methods of preventing or slowing corrosion using such coating compositions.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 19, 2015
    Inventors: Jinglei Yang, Mingxing Huang
  • Publication number: 20150072146
    Abstract: The present invention relates to a method for preparing capsules comprising a liquid core, a stiffened intermediate envelope and a gelled external envelope, comprising a step of forming a multi-component liquid drop, a gelification step and a stiffening step. The present invention also relates to a method for preparing capsules comprising a liquid core and a stiffened envelope, comprising a step of forming a multi-component liquid drop, a gelification step, a stiffening step and a depolymerizing step.
    Type: Application
    Filed: January 31, 2013
    Publication date: March 12, 2015
    Applicant: CAPSUM
    Inventors: Jerome Bibette, Mathieu Goutayer
  • Publication number: 20150057210
    Abstract: The need for a stable, quick dissolving unit dose article delivering good fabric care benefit is met by combining a cationic polymer with a fatty acid or salt in a non-aqueous composition, that is comprised within a water-soluble or dispersible film. By combining the cationic polymer with the fatty acid, the cationic polymer is prevented from reducing the solubility of the encapsulating film.
    Type: Application
    Filed: November 7, 2014
    Publication date: February 26, 2015
    Inventors: Regine LABEQUE, Peter Jos Emma VAN GINDEREN, Marc JENNEWEIN
  • Publication number: 20150037427
    Abstract: The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nano spray techniques.
    Type: Application
    Filed: September 20, 2012
    Publication date: February 5, 2015
    Inventors: Simon Benita, Orit Amsalem, Taher Nassar
  • Publication number: 20150021800
    Abstract: Provided is a herbicidal composition comprising a herbicidally active compound selected from a difluoromethanesulfonylanilide compound represented by the general formula (I): wherein R1 represents a hydrogen atom, an alkyl group or an alkoxyalkyl group; or a salt thereof encapsulated in a microcapsule, or a herbicidal composition comprising the herbicidally active compound encapsulated in a microcapsule and a benzoic acid compound represented by the general formula (II): wherein R2 represents a hydrogen atom, an alkyl group having 1 to 15 carbon atoms, a hydroxyl group, a nitro group, or an amino group; and R3 represents a hydrogen atom, an alkali metal atom or an alkyl group. The herbicidal composition exert a pharmacological effect for a prolonged period of time, can alleviate or prevent any harmful effect and can reduce the environmental load.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 22, 2015
    Inventors: Toshihiro IKEUCHI, Tetsuo OHKAWA
  • Patent number: 8927009
    Abstract: A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: January 6, 2015
    Assignee: AbbVie Inc.
    Inventors: Ping Tong, Deliang Zhou, Geoff G. Z. Zhang, Katherine R. Heemstra, Cristina M. Fischer, Nathaniel D. Catron, Eric A. Schmitt, Yeshwant D. Sanzgiri
  • Publication number: 20140377333
    Abstract: A method of making dietary supplement compositions includes generating an aqueous phase, generating an oil phase, performing a first homogenizing step by mixing the aqueous and oil phases, adding reduced glutathione to the aqueous-oil composition and performing a second homogenizing step by mixing the aqueous-oil composition and reduced glutathione, adding a first flavor to the aqueous-oil-glutathione composition, performing a third homogenizing step by mixing the aqueous-oil-glutathione composition and the first flavor, adding xanthan gum dispersed with glycerin to the aqueous-oil-glutathione-first-flavor composition and performing a fourth homogenizing step by mixing the aqueous-oil-glutathione-first-flavor composition and xanthan gum; adding a second flavor to the aqueous-oil-glutathione-first-flavor-xanthan composition and performing a fifth homogenizing step by mixing the aqueous-oil-glutathione-first-flavor-xanthan composition and the second flavor so as to form a dietary supplement composition.
    Type: Application
    Filed: December 18, 2013
    Publication date: December 25, 2014
    Applicant: ZEOLIFE INC.
    Inventors: James John YIANNIOS, Subhash KEKATPURAY
  • Publication number: 20140347718
    Abstract: The invention provides an electrophoretic medium comprising at least two types of particles having substantially the same electrophoretic mobility but differing colors. The invention also provides article of manufacture comprising a layer of a solid electro-optic medium, a first adhesive layer on one surface of the electro-optic medium, a release sheet covering the first adhesive layer, and a second adhesive layer on an opposed second surface of the electro-optic medium.
    Type: Application
    Filed: August 13, 2014
    Publication date: November 27, 2014
    Inventors: Gregg M. Duthaler, Karl Raymond Amundson, Barrett Comiskey, Holly G. Gates, Alberto Goenaga, John E. Ritter, Michael L. Steiner, Russell J. Wilcox, Robert W. Zehner, Anthony Edward Pullen
  • Publication number: 20140342858
    Abstract: A spherical pellet marking round for gas propelled guns, such as airsoft electric guns and gas blow back guns, allows a user or military/law enforcement trainees to actually when they hit their opponent. The marking round is heavier than conventional gas propelled gun rounds, allowing for more reliable breaking on target. The marking round has a hard, brittle shell and is sized for the gun or rifle type. The marking round can include colored marking material, ultraviolet, infrared, forward looking infrared (FLIR) and luminous “glow-in-the-dark” shells for tracer versions. An oversized wedge can be used in production that allows for heavier weighted fill material to be used.
    Type: Application
    Filed: May 14, 2013
    Publication date: November 20, 2014
    Inventor: Kerry Thaddeus Bowden
  • Publication number: 20140336284
    Abstract: Disclosed is a powder antifoaming agent containing: (A) a hydrophobic organopolysiloxane that has a viscosity at 25° C. of 10-100,000 mm2/s; (B) a fine silica powder; (C) a surfactant; and (D) a water-soluble encapsulating agent that is in a solid state at 25° C. This powder antifoaming agent is characterized by being obtained by spray drying a dispersion liquid that is obtained by dispersing a silicone oil compound, which is obtained by mixing the component (A) and the component (B), and the component (D) in water in the presence of the component (C), and is also characterized in that the silicone oil compound is encapsulated by the component (D) that serves as an outer shell. Since the present powder antifoaming agent does not contain water by being produced by a spray drying method, the powder antifoaming agent is free from problems of emulsion antifoaming agents such as separation and putrefaction.
    Type: Application
    Filed: October 18, 2012
    Publication date: November 13, 2014
    Inventors: Takato Sakurai, Shinji Irifune
  • Patent number: 8859003
    Abstract: Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optionally coating the particulate with a combination of enteric material and plasticizer.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: October 14, 2014
    Assignee: Intercontinental Great Brands LLC
    Inventors: Ahmad Akashe, Anilkumar Ganapati Gaonkar, Les Lawrence, Amado R. Lopez, George W. Haas, Dana Sebesta, Yan Wang
  • Patent number: 8852472
    Abstract: The present invention is related to a lipid composition comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is removable from the lipid composition under in vivo conditions.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: October 7, 2014
    Assignee: Silence Therapeutics GmbH
    Inventors: Oliver Keil, Jörg Kaufmann
  • Publication number: 20140234411
    Abstract: The present invention is related to a seamless capsule which easily dissolves in the oral cavity etc. The present invention provides a seamless capsule comprising a capsule content solution, and a capsule shell enclosing the capsule content solution, wherein the capsule shell comprises a gelatin having a bloom value of 50 to 190 and wherein the seamless capsule has a capsule shell-dissolution time of 60 seconds or less when the dissolution time is determined by a disintegration test using water as a test solution.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 21, 2014
    Inventors: Ryosei Kamaguchi, Osami Nakano, Hisaaki Hatanaka
  • Publication number: 20140221961
    Abstract: A nano-carrier comprising an antiproliferative drug encapsulated by a lipophilic enhancement agent.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Inventor: Juan Granada
  • Publication number: 20140174684
    Abstract: Expandable microspheres formed by suspension polymerization using a shot growth method are provided. The microspheres are formed of a continuous, gas impermeable shell surrounding a blowing agent. The shell includes a first polymer layer formed from primary monomers and a second layer that includes a chemically reactive monomer or a high Tg monomer. To form the microspheres, the primary monomers are polymerized in a reaction vessel to an approximate 90% polymerization, at which time a secondary monomer that is either a monomer having a Tg of at least 85° C. or a chemically reactive monomer, is added to the reaction vessel to drive the polymerization reaction to completion. The outer layer thus contains either a larger amount of the high Tg monomer or a chemically reactive monomer that possesses the ability to covalently bond a cationic species. The microspheres may be used in papermaking processes to increase the paper bulk.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: INTERNATIONAL PAPER COMPANY
    Inventors: YAOLIANG HONG, KOSARAJU KRISHNA MOHAN, VICTORIA LAURENTIA DIMONIE, MARK FAGAN, ANDREW KLEIN, ERIC SCOTT DANIELS, BRIAN BOYARS, PETER M. FROASS, CHRISTOPHER D. ANDERSON, EDWARD DAVID SUDOL
  • Patent number: 8741337
    Abstract: An encapsulated material containing an oxidation-sensitive core is covered by at least a dried phospholipid layer, and contains at least one phytosterol in the core, the phospholipid layer or in a further layer or layers. By using microencapsulation, oxidatively unstable materials may be provided with a synthetic protective barrier and rendered less susceptible to oxidative degradation.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: June 3, 2014
    Assignee: Aveka, Inc.
    Inventors: William A. Hendrickson, John M. Finney, Olaf C. Moberg, Christopher J. Rueb, Robert G. Bowman, Chetan S. Rao, Nita M. Bentley
  • Patent number: 8728449
    Abstract: Water-soluble articles such as films, which can be made resistant to contact with small amounts of water, and methods of making the same are disclosed. The water-soluble article is formed from a water-soluble film-forming composition, such as polyvinyl alcohol, and includes a salt that is distributed more closely to at least one of the surfaces than throughout its thickness.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: May 20, 2014
    Assignee: Monosol LLC
    Inventors: Andrew P. Verrall, Steven G. Friedrich
  • Patent number: 8716214
    Abstract: In a fragrance and/or aroma composition for the targeted release of fragrances and/or aromas in the form of a solid lipid nanoparticle (SLN) dispersion, in which lipid-based nanoparticles are present which are stabilized by an emulsifier monolayer, one or more membrane layers or other auxiliaries, the fragrances and/or aromas are included in the nanoparticles and/or in the emulsifier monolayer or the membrane layers.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: May 6, 2014
    Assignee: OTC GmbH
    Inventors: Gerd Dahms, Andreas Jung, Holger Seidel
  • Patent number: 8715732
    Abstract: Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: May 6, 2014
    Assignee: Cornell University
    Inventors: Dan Luo, Jong Bum Lee, Hisakage Funabashi
  • Publication number: 20140120178
    Abstract: The present invention provides a multi-component encapsulated reactive formulation comprising a mixture of two or more dry powder components, where each dry powder component is formed from a phase inversion process involving vigorous mixing. The dry powder is stabilized by hydrophobic colloidal particles, which assist in generating stable “dry water” microdroplets. One dry powder component comprises hydrophobic colloidal particles encapsulating microdroplets comprising an aqueous solution of one reactant, and the at least one other dry powder component comprises hydrophobic colloidal particles encapsulating microdroplets comprising an aqueous solution of another reactant. When the encapsulated formulation is agitated such that the encapsulates are broken, the encapsulates rupture and the two aqueous solutions undergo a reaction upon contact.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 1, 2014
    Applicant: Pibed Limited
    Inventors: John David Hines, Bernard Paul Binks, Pierre Bruno Grascha
  • Publication number: 20140072625
    Abstract: Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.
    Type: Application
    Filed: November 12, 2013
    Publication date: March 13, 2014
    Applicant: Banner Pharmacaps Inc.
    Inventor: Nachiappan Chidambaram
  • Patent number: 8663511
    Abstract: A system that incorporates teachings of the present disclosure may include, for example, a method for applying a force to at least one of an inner stream, an outer stream or both of a combined stream to produce a plurality of capsules, receiving image data, processing the image data, detecting undesirable capsules from the processed image data, applying a bias charge only to the detected undesirable capsules, and segregating the biased undesirable capsules from the unbiased desirable capsules. Additional embodiments are disclosed.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: March 4, 2014
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kyekyoon Kim, Hyungsoo Choi
  • Patent number: 8663690
    Abstract: Methods of nanoencapsulation are described herein. Embodiments of the method utilize the coacervation of a cationic polyelectrolyte with an anionic polyelectrolyte to form a novel capsular matrix. In particular, the novel methods may be used to encapsulate a suspension of a hydrophobic material such as a carotenoid. The disclosed methods do not require lengthy pH adjustments nor do they require the use of any toxic crosslinking agents. In one embodiment, a method of encapsulation comprises dispersing a hydrophobic compound in an organic solvent to form a solution. The method also comprises admixing an anionic polyelectrolyte and a cationic polyelectrolyte with the suspension to form a mixture. In addition, the method comprises quiescently cooling the mixture so as to cause self-crosslinking of a capsular matrix encapsulating the hydrophobic particles.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: March 4, 2014
    Assignee: William Marsh Rice University
    Inventors: Muhammed K. Gheith, Yu-Lun Fang, Michael S. Wong
  • Publication number: 20140053855
    Abstract: A smoking device includes a recipient or able to receive burning products, preferably tobacco, and a filter element connected to the recipient, wherein the filter includes at least one breakable capsule, the capsule having a initial crush strength from 0.5 to 2.5 kp, and keeping a crush strength from 0.5 to 2.5 kp and a deformation of less than two third of its diameter prior to rupture after having been submitted to a smoking test. The invention is also relating to the capsule suitable for being incorporated in a smoking device, and to the process of manufacture of the capsule.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 27, 2014
    Applicant: V. MANE FILS
    Inventors: DIDIER HARTMANN, JEAN-MICHEL HANNETEL, NATHALIE COURSIERES, JEAN MANE
  • Patent number: 8641900
    Abstract: A method and a device for continuously preparing microspheres, and a collection unit thereof are provided. The collection unit for collecting microspheres in the solution comprises a tank and a first plate. The first plate is removably disposed in the tank. The first plate, when lay across the tank, has its two ends came in contact with the sidewall of the tank so as to divide the tank into a first chamber and a second chamber. The tank has an outlet located in the second chamber. After the solution with microspheres are input to the first chamber of the tank, the microspheres are deposited around the first plate, and the solution is caused to pass through or over the first plate to the second chamber and output from the outlet.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: February 4, 2014
    Assignee: Taiwan Biotech Co., Ltd
    Inventors: Shou-Min Huang, Chun-Wei Liu, Kuo-Hua Yang
  • Patent number: 8628851
    Abstract: The invention provides a method for encapsulating a liquid, which method comprises the steps of providing a suspension of droplets of the liquid to be encapsulated; stabilizing the suspension of droplets with a surfactant; adding a layered inorganic material to the stabilized suspension; and subjecting the suspension to a treatment which establishes that a shell of a hybrid material is formed around the droplets, which hybrid material comprises at least part of the inorganic material and at least part of the surfactant. The invention further provides encapsulated liquid droplets obtainable by said method.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: January 14, 2014
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Sabine Fischer, Hartmut Rudolf Fischer, Jacobus Eversdijk, Renz Jeroen Van Ee
  • Publication number: 20130270726
    Abstract: The present disclosure relates to a method of forming microcapsules. The method may include combining an active agent in a first solvent S1 and forming a dispersed phase of the active agent in the first solvent, wherein the dispersed phase of active agent has a surface. A reactant may be added to the first solvent, wherein the reactant reacts with the surface of the active agent dispersed phase and encapsulates the active agent wherein at least a portion of the active agent remains unreacted.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventor: James D. OXLEY
  • Publication number: 20130244037
    Abstract: Methods and assemblies for the construction of liquid-phase alloy nanoparticles are presented. Particle formation is directed by molecular self-assembly and assisted by sonication. In some embodiments, eutectic gallium-indium (EGaIn) nanoparticles are formed. In these embodiments, the bulk liquid alloy is ultrasonically dispersed, fast thiolate self-assembly at the EGaIn interface protects the material against oxidation. The assembly shell has been designed to include intermolecular hydrogen bonds, which induce surface strain, assisting in cleavage of the alloy particles to the nanoscale. X-ray diffraction and TEM analyses reveal that the nanoscale particles are in an amorphous or liquid phase, with no observed faceting.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 19, 2013
    Applicant: The Regents of the University of California
    Inventors: James Nathan Hohman, Paul S. Weiss
  • Patent number: 8529805
    Abstract: The invention relates to a method for the production of water absorbent polymer particles by polymerizing drops, comprising at least one monomer in a gas phase surrounding the drops, wherein the drops are produced by surrounding a first monomer solution with a second monomer solution and polymerizing the second monomer solution to a higher cross-linked polymer than the first monomer solution.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: September 10, 2013
    Assignee: BASF SE
    Inventors: Dennis Loesch, Matthias Weismantel, Marco Krüger, Antje Ziemer
  • Publication number: 20130224489
    Abstract: A quad-centric nozzle and system for hydrocapsule encapsulation is disclosed. In at least one embodiment, a quad-centric nozzle is disclosed for encapsulating discrete droplets of liquid by generating a continuous coating or layer of a polymerizable liquid which is substantially immiscible with the core liquid. In at least one embodiment, the quad-centric nozzle includes: a material feed port assembly, a polymer feed port assembly, a first water feed port assembly, a second water feed port assembly and an encapsulated material exit port assembly. In at least one embodiment, the quad-centric nozzle is configured for use in a system for hydrocapsule encapsulation having a pressure control system, a water control system and sparging column, and an ultraviolet exposure chamber system.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 29, 2013
    Applicant: HYDROCAPSULE, INC.
    Inventors: Michael Pitsokos, Ara Manukian, William Toreki
  • Publication number: 20130221552
    Abstract: A metered pump system for hydrocapsule encapsulation is disclosed. In at least one embodiment, a system for hydrocapsule encapsulation includes a nozzle assembly and metered pump for encapsulating discrete droplets of liquid by generating a continuous coating of a polymerizable liquid which is substantially immiscible with the core liquid. The metered pump system is configured to control a stroke length and a pulsation speed to attain constant shear with each pump of water, and a volume of water in each stroke and a speed of the stroke is controlled. In at least one embodiment, the nozzle includes a material feed port, a polymer feed port, a water feed port, and an encapsulated material exit port. In at least one embodiment, the metered pump is configured for use in a hydrocapsule encapsulation system having a pressure control system, a water control system, sparging column, and ultraviolet exposure chamber system.
    Type: Application
    Filed: November 28, 2012
    Publication date: August 29, 2013
    Inventor: Michael Pitsokos
  • Patent number: 8493648
    Abstract: Provided are a method of fabricating an electrophoretic ink, the electrophoretic ink formed using the method, and an electrophoretic display having the same. The method of fabricating an electrophoretic ink includes dispersing pigment particles into a dielectric fluid; adding at least one monomer and an initiator into the dielectric fluid; and forming polymeric membranes surrounding the pigment particles in the dielectric fluid. Since the pigment particle surrounded by the polymeric membrane and the dielectric fluid in which the pigment particle is dispersed can be utilized as the electrophoretic ink as they are without a follow-up cleaning process, the method of fabricating the electrophoretic ink is simplified.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 23, 2013
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Chul Am Kim, Hyeonjung Yoo, Kyung Soo Suh, Seung Youl Kang
  • Patent number: 8470215
    Abstract: A method for manufacturing breakable capsules (50) that are useful for incorporating into a tobacco product (10), such as smoking articles and smokeless tobacco products, is provided. The method comprises forming a plurality of droplets comprising a core composition and a coating composition. The coating composition comprises a material that gelates in contact with a multivalent ion. The method also comprises introducing the plurality of droplets in a first aqueous solution having a first concentration of a first multivalent ion such that the coating composition of the plurality of droplets gelates to form a plurality of raw capsules. The method further comprises introducing the plurality of raw capsules in a second aqueous solution having a second concentration of a second multivalent ion, wherein the second concentration is higher than the first concentration, such that the coating composition of the plurality of raw capsules hardens to form a plurality of breakable capsules (50).
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: June 25, 2013
    Assignee: R. J. Reynolds Tobacco Company
    Inventor: Wenhui Zhang
  • Publication number: 20130154138
    Abstract: The present invention provides a preparing method of an allicin injection and the low temperature continuous stirring ultrafiltration device thereof. Said preparing method consists of the following steps: extracting allicin; diluting the allicin with solvent precooled tol-4 in a clean environment, adding nitrogen gas or argon gas, and then encapsulating the solution to obtain allicin injection with different specifications.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 20, 2013
    Applicant: XINJIANG AILEXIN PHARMACEUTICAL CO., LTD.
    Inventor: XINJIANG AILEXIN PHARMACEUTICAL CO., LTD.
  • Patent number: 8465835
    Abstract: A method of making core-shell capsules containing a water-immiscible liquid, comprising the steps of (a) dispersing into the water-immiscible liquid a crosslinking agent that is inactive under the conditions of the dispersion; (b) emulsifying the resulting dispersion into an aqueous solution of a crosslinkable hydrocolloid; and (c) activating the crosslinking agent to cause the hydrocolloid to crosslink at the dispersion/solution interface. The method is simple and provides capsules that can be cold-loaded. The capsule material may be made of vegetable-derived materials.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: June 18, 2013
    Assignee: Givaudan S.A.
    Inventor: Robert Guisinger
  • Patent number: 8449919
    Abstract: The present invention discloses a method for preparing alginate nanocapsules, including the steps of: (a) forming a water-in-oil emulsion including an alginate in water, an oil, and at least one nonionic surfactant; and (b) separating the aqueous phase and oil phase to obtain the semisolid form alginate nanocapsules; and (c) by ionically crosslinking the alginate with calcium ions to obtain a colloidal form of calcium alginate nanocapsules for drug delivery.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: May 28, 2013
    Inventors: Bingqian Shen, Shengli Yang
  • Publication number: 20130115261
    Abstract: Use of formulations comprising polyurea microcapsules obtainable by interfacial polymerization of diphenylmethylen-4,4?-diisocyanate (MDI), optionally in admixture with polymethylenepolyphenylisocyanate (PAPI), said formulations having a prolonged knockdown and killing effect longer than at least 3 months, preferably at least of 6 months, still more preferably at least of 9 months from the application, wherein the microcapsules comprise: an active principle selected from the pyrethroid and/or neonicotinoid classes, synergizing agents selected between PEO and Verbutin, the concentration of the active principle in the microcapsule as % by weight on the total of the microcapsule is comprised between to and 60% the average diameter of the microcapsules is comprised between 2 and 50 ?m.
    Type: Application
    Filed: November 1, 2012
    Publication date: May 9, 2013
    Applicants: SIPCAM S. P. A., ENDURA S. P. A.
    Inventors: ENDURA S. P. A., SIPCAM S. P. A.
  • Publication number: 20130114125
    Abstract: A multi-color electrophoretic display (EPD) device, an image sheet, and a method of fabricating the same. The multi-color EPD device includes: a plurality of unit color pixels; and a plurality of color capsules, each comprising color capsule shell which stores a dielectric fluid and at least one type of electrophoretic particles dispersed in the dielectric fluid, the plurality of color capsules being arranged to define subpixels of each of the plurality of unit color pixels.
    Type: Application
    Filed: March 25, 2011
    Publication date: May 9, 2013
    Inventors: Chul Hwan Kim, Yong Eui Lee
  • Publication number: 20130099403
    Abstract: A Semen Cassiae soft capsule for lowering blood lipids and losing weight and the preparation method thereof. The content of the soft capsule consist of the following components by weight part: 10-60 parts of ethanol soluble extract powder of Semen Cassiae, 2-10 parts of aqueous soluble extract powder of Radix Glycyrrhizae, 10-30 parts of evening primrose oil, 5-20 parts of sea buckthorn seed oil and 2-10 parts of beeswax.
    Type: Application
    Filed: June 28, 2011
    Publication date: April 25, 2013
    Inventor: Jianzhong Ma
  • Publication number: 20130101849
    Abstract: Micro- and nano-sized particles, agglomerates and fibers are generated from high molecular weight water-soluble biopolymers applying supercritical fluid technology. A method of producing micro- or nanoparticles from an aqueous solution of a high molecular weight biopolymer includes the step of spraying the aqueous solution together with a mixture of a compressible gas and a water-soluble co-solvent/antisolvent into a pressurized chamber. The method may be adapted to impregnate the micro- or nanoparticles with a bioactive material. A method for microencapsulating a bioactive material with a biopolymer is also provided.
    Type: Application
    Filed: April 1, 2011
    Publication date: April 25, 2013
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Feral Temelli, Bernhard Seifried
  • Publication number: 20130093110
    Abstract: To provide a vesicle-containing composition wherein a perfume component is stably incorporated in the vesicle bilayer membrane composed of a silicone surfactant and to provide a simple production method of the vesicle-containing composition wherein a perfume component is stably incorporated. A vesicle-containing composition comprising; (A) a perfume, (B) a silicone oil, (C) a silicone surfactant, (D) one or more selected from the group consisting of ethanol, propylene glycol, dipropylene glycol, and 1,3-butylene glycol, and (E) water; wherein the (C) silicone surfactant forms vesicles, and the (A) perfume and the (B) silicone oil are present in the vesicle bilayer membrane.
    Type: Application
    Filed: December 6, 2012
    Publication date: April 18, 2013
    Applicant: SHISEIDO COMPANY LTD.
    Inventor: SHISEIDO COMPANY LTD.
  • Publication number: 20130078308
    Abstract: An encapsulation device includes: a fluid injection device that injects a first liquid forming a core; a liquid film holder that holds in film form a second liquid forming a shell containing the core; and a liquid contact device that makes the shell in contact with a third liquid, in which the first liquid is injected toward a liquid film of the second liquid retained by the liquid film holder to form a core, the core is wrapped with the second liquid on passing through the liquid film of the second liquid, thereby forming the shell, and the shell is made in contact with the third liquid to induce chemical reaction.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 28, 2013
    Applicant: SEIKO EPSON CORPORATION
    Inventor: SEIKO EPSON CORPORATION
  • Publication number: 20130065811
    Abstract: The need for a means to formulate fluid compositions for use in water-soluble unit dose articles having higher levels of water is met by incorporating a di-amido gellant into the fluid composition. The di-amido gellant also simplifies the addition of ingredients to water-soluble unit dose articles, such as microcapsules, that are typically added as aqueous suspensions or slurries.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 14, 2013
    Inventors: Susana FERNANDEZ-PRIETO, Isabelle GUIMET, Regine LABEQUE, Walter August Maria BROECKX, John SMETS
  • Publication number: 20130064997
    Abstract: The invention provides a multicolor and marbleized paintball and softgel gelatin capsule manufactured by using a dispensing system comprising: a first box having a bottom thereof for storing gelatin of one color and having an unobstructed discharge opening at the bottom for spreading a layer of gelatin, a second box for storing and dispensing a gelatin of a second color and having means for securing the same to said first box with said spaced discharge openings disposed above and away from said unobstructed discharge opening thereby dispensing a plurality of spaced lines onto said layer, said second box including an adjustable plate for regulating the flow of gelatin through said openings, said first and second boxes having means for introducing different colored gelatin, and wherein said second box has a plurality of spaced discharge openings extending across a width thereof and slanted downward to facilitate the discharge of gelatin.
    Type: Application
    Filed: July 2, 2012
    Publication date: March 14, 2013
    Applicant: PROCAPS SA
    Inventor: Juan Pablo Manotas Dugand
  • Publication number: 20130059000
    Abstract: A process for making hemoglobin based oxygen carrier (HBOC) containing pharmaceutical composition suitable for oral delivery and the composition formed thereby are described. There are three exemplary composition configurations which include (1) hemoglobin-loaded nanoparticles solution, (2) enteric-coated hemoglobin capsules and (3) enteric-coated hemoglobin tablets. To facilitate the bioavailability and bio-compatibility of hemoglobin, intestinal absorption enhancers are added in each of the HBOC formulations. Protective layers ensure delivery of an intact hemoglobin structure in intestinal tract without degradation in the stomach. The HBOC formulations may be used for preventive or immediate treatment of high altitude syndrome (HAS) or for treatment of hypoxic conditions including blood loss, anemia, hypoxic cancerous tissue, and other oxygen-deprivation disorders.
    Type: Application
    Filed: August 23, 2012
    Publication date: March 7, 2013
    Inventors: Bing Lou WONG, Sui Yi KWOK
  • Publication number: 20130049240
    Abstract: A system that incorporates teachings of the present disclosure may include, for example, a method for applying a force to at least one of an inner stream, an outer stream or both of a combined stream to produce a plurality of capsules, receiving image data, processing the image data, detecting undesirable capsules from the processed image data, applying a bias charge only to the detected undesirable capsules, and segregating the biased undesirable capsules from the unbiased desirable capsules. Additional embodiments are disclosed.
    Type: Application
    Filed: September 24, 2012
    Publication date: February 28, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventor: The Board of Trustees of The University of IL
  • Publication number: 20130037978
    Abstract: Capsules and similar objects are made from materials having diamond (sp3) lattice structures, including diamond materials in synthetic crystalline, polycrystalline (ordered or disordered), nanocrystalline and amorphous forms. The capsules generally include a hollow shell made of a diamond material that defines an interior region that may be empty or that may contain a fluid or solid material. Some of the capsules include access ports that can be used to fill the capsule with a fluid. Capsules and similar structures can be manufactured by growing diamond on suitably shaped substrates. In some of these methods, diamond shell sections are grown on substrates, then joined together. In other methods, a nearly complete diamond shell is grown around a form substrate, and the substrate can be removed through a relatively small opening in the shell.
    Type: Application
    Filed: October 18, 2012
    Publication date: February 14, 2013
    Applicant: Terraspan LLC
    Inventor: Terraspan LLC
  • Publication number: 20130037977
    Abstract: The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.
    Type: Application
    Filed: April 7, 2011
    Publication date: February 14, 2013
    Inventors: Paul A. Burke, Marian E. Gindy, David J. Mathre, Varun Kumar, Robert K. Prud'homme
  • Publication number: 20130028963
    Abstract: The present invention provides a vesicle having a unilamellar bilayer including a lipid and a second bilayer component selected from a membrane protein or a functionalized lipid. The vesicle also includes a component encapsulated by the unilamellar bilayer, wherein the encapsulated component includes a protein, a peptide, an enzyme, an oligonucleotide, or a polynucleotide. Also included are methods of making the vesicles of the present invention.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 31, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel A. Fletcher, Thomas Li, Sapun Parekh, Jeanne Stachowiak, Allen Liu, David Richmond, Eva Schmid