With Color Transmitting Filter Patents (Class 356/414)
  • Patent number: 10260033
    Abstract: A method and apparatus are disclosed for the collection of light scattered from a liquid sample contained within a multiwell plate for which evaporation from the wells is mitigated by the application of a barrier between the liquid sample and the environment. A vertical thermal gradient is applied across the vessel so that condensation is inhibited from forming on the interior surface of the barrier, thus permitting clear illumination of the sample for visual imaging, fluorescence studies and light scattering detection.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: April 16, 2019
    Assignee: WYATT TECHNOLOGY CORPORATION
    Inventors: Steven P. Trainoff, Shiva Ramini
  • Patent number: 10145178
    Abstract: A method and apparatus for determining the effectiveness of bearing seals in a roller cone drill bit. The bit includes a sensor in optical communication with the bearing lubricant. The sensor includes a light source, an optical filter, and an optical detector arranged so that light interacts with the lubricant, is filtered, and detected, wherein the detected light is indicative of the amount of contaminant within the lubricant. The optical filter is preferably an integrated computing element that filters preselected orthogonal components from the light.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: December 4, 2018
    Assignee: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Shilin Chen, Micheal Burl Crawford
  • Patent number: 9976192
    Abstract: The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: May 22, 2018
    Assignee: LDIP, LLC
    Inventors: Reuven Duer, Yun-Pei Chang, Ashutosh Shastry
  • Patent number: 9782175
    Abstract: A surgical evaluation and guidance system for use in extravacular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically coupled to the optical coherence tomography engine; and a signal processing and display system adapted to communicate with the optical coherence tomography engine to receive imaging signals therefrom. An optical coherence tomography vessel probe for use in extravacular evaluation and guidance of fluid vessel surgeries, includes a probe body having a proximal end and a distal end; an optical relay system disposed within the probe body; and a vessel adapter at least one of attached to or integral with the probe body at the distal end of the probe body, wherein the vessel adapter defines a groove that is configured to accept one of a fluid vessel and a lymphaticovenous vessel.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: October 10, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jin U. Kang, Yong Huang, Gerald Brandacher, Zuhaib Ibrahim
  • Patent number: 9702862
    Abstract: A method for measuring fuel contamination in oil that uses a material in contact with oil whereby fuel intrusion into the oil will change the electrical, mechanical, and/or chemical properties of the material as compared to the same electrical, mechanical, and/or chemical properties of the material when in contact only with mineral or synthetic oil only.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 11, 2017
    Assignee: Voelker Sensors, Inc.
    Inventor: Joe D. Hedges
  • Patent number: 9702815
    Abstract: A sampling device including a Near-Infrared Spectroscopy (NIRS) fiber optic probe and methods of using the device are provided. The sampling device performs both NIRS data collection and physical sample collection. The sampling device operates by inserting the device into a powder or blend to be sampled, collecting a sample within the sample chamber in the device, and performing NIRS analysis of the sample within the sample chamber.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 11, 2017
    Assignee: BOEHRINGER INGELHEIM ROXANE, INC.
    Inventors: Atish Dalal, Daniel Hill
  • Patent number: 9664702
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: May 30, 2017
    Assignee: Theranos, Inc.
    Inventors: Elizabeth Holmes, Joy Roy
  • Patent number: 9504120
    Abstract: A system includes a plurality of light-emitting devices electrically coupled together. A temperature of each of the light-emitting devices is correlated with a voltage of said light-emitting device. The system includes a current driver configured to control an amount of current through at least a subset of the light-emitting devices. The system includes electronic circuitry that is electrically coupled to the subset of the light-emitting devices. The electronic circuitry is configured to: measure a voltage of the subset of the light-emitting devices while the light-emitting devices are in operation; determine, based on the measured voltage, whether the subset of the light-emitting devices is hotter than an acceptable temperature threshold; and instruct the current driver to reduce the amount of current through the subset of the light-emitting devices if the subset of the light-emitting devices has been determined to be hotter than the acceptable temperature threshold.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: November 22, 2016
    Assignee: EPISTAR CORPORATION
    Inventor: Wei-Yu Yeh
  • Patent number: 9296019
    Abstract: The invention concerns a method for discerning and sorting suitable products in a product flow having a certain concentration of a component versus anomalous products having this component in an anomalous concentration, whereby a beam of light strikes these products, and the absorption of this beam of light by said component in the products is detected by measuring the intensity of the light reflected by the products at least at a wavelength or in at least a wavelength band which is situated between 900 nm and 2500 nm in order to generate a detection signal on the basis of said absorption, whereby a product will be identified as an anomalous product if said detection signal exceeds a threshold value.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: March 29, 2016
    Assignee: TOMRA SORTING NV
    Inventors: Paul Berghmans, Christiaan Fivez, Johan Speybrouck
  • Patent number: 9075228
    Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies. Methods of aligning apertures of optical assemblies with viewing openings of a filter wheel or an optical assembly receiver and securing the optical assemblies to the filter wheel or the optical assembly receiver using a magnetic force.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: July 7, 2015
    Assignee: CELLOMICS, INC.
    Inventors: Dirk John Vandenberg, III, Keith R. Heffley
  • Patent number: 8992860
    Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 31, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
  • Patent number: 8709356
    Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 29, 2014
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
  • Patent number: 8697008
    Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: April 15, 2014
    Assignee: Eastman Kodak Company
    Inventors: Andrew Clarke, Nicholas J. Dartnell, Christopher B. Rider
  • Patent number: 8603772
    Abstract: This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non-invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: December 10, 2013
    Assignee: Bug Lab LLC
    Inventors: Martin P. Debreczeny, Jaime Romero, Ethan Petersen
  • Patent number: 8062900
    Abstract: A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: November 22, 2011
    Assignee: Corning Incorporated
    Inventor: Robert A. Modavis
  • Patent number: 8064061
    Abstract: A sample analyzer is disclosed that comprising: a light source section for emitting light; a first optical information acquiring section for illuminating a sample with the light emitted by the light source section, and for acquiring first optical information; and a second optical information acquiring section for illuminating a measurement specimen, to be prepared by adding a reagent to the sample, with the light emitted by the light source section, and for and acquiring second optical information. A sample analyzing method, intended for use in an automated sample analyzer, is also described.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: November 22, 2011
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Naohiko Matsuo, Takashi Yamato
  • Patent number: 7817277
    Abstract: A fiber-optic probe includes first and second optical fibers disposed in a body, a liquid sampling region between ends of the fibers and a reflector, and apertures communicating with the sampling region. The probe may be inserted in media in a vessel. Optical signals are transmitted through the first fiber, the sampling region and second fiber. The sampling region is offset from other parts of the probe so that bubbles or particulates flow out from the sampling region without being obstructed by the probe.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: October 19, 2010
    Assignee: Varian, Inc.
    Inventors: George Bryan Crist, C. J. Anthony Fernando
  • Patent number: 7733488
    Abstract: An optical reader having an array of differing-color light sources and a controller for controlling the light sources and acquisition of optical data. The light sources are arranged, and the controller is configured, to allow rapid acquisition of optical data regarding individual sample wells of a cluster of such wells. In some embodiments, multiple ones of the differing-color light sources are illuminated simultaneously for acquiring optical data on a corresponding number of sample wells. Depending on the configuration of the array and number of differing-color light sources illuminated simultaneously, the optical reader can acquire optical data for several wavelengths in a fraction of the time of conventional optical readers. Other embodiments include one or more non-contact temperature sensors for acquiring temperature data substantially simultaneously with the optical data.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: June 8, 2010
    Assignee: Revolution Optics, LLC
    Inventor: Lyle C. Johnson
  • Patent number: 7561271
    Abstract: A low cost calorimeter wherein a linear taper potentiometer proportions the current through sample and reference solid state light sources in a near logarithmic fashion. The position of the potentiometer slider is proportional to the absorbance of the solution in the sample path when the light intensity of the two paths is balanced. The light intensity may be balanced visually or with a simple electronic comparator.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: July 14, 2009
    Inventor: James E. Davis
  • Patent number: 7468796
    Abstract: An absorption detection system is provided. The system includes a plurality of monochromatic light sources and a separator for separating the light from the plurality of monochromatic light sources into a plurality of wavelengths. A plurality of detectors, receives light of a single wavelength to measure absorption of light in a biological sample.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: December 23, 2008
    Assignee: CompuCyte Corporation
    Inventors: Edgar A. Luther, Bruce Miller
  • Patent number: 7423751
    Abstract: The invention provides systems and methods for detecting aerosols. The systems and methods can be used to detect harmful aerosols, such as, bio-aerosols.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: September 9, 2008
    Assignee: Northrop Grumman Corporation
    Inventors: Peter P. Hairston, Carl B. Freidhoff
  • Patent number: 7414724
    Abstract: An apparatus for photometrically testing several specimens each irradiated by a light source, the light altered by the specimens being detected by an optical device and analyzed, the apparatus including a light source, a plurality of sample holders configured adjacent to one another on a support, a detector that receives altered light from sample within the sample holders, the detector including a filter for eliminating interfering light, a sensor having a sensor face and a diffusing optical member located between the filter and the sensor, wherein light is diffused and shines on a greater portion of the sensor surface, and with a more homogeneous brightness as compared to when the light is not diffused.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: August 19, 2008
    Assignee: Eppendorf AG
    Inventors: Gerd Eckert, Lutz Timmann, Markus Lapczyna, Arne Schafrinski
  • Patent number: 7321428
    Abstract: A process photometer which includes an insulated and a non-insulated compartment. The insulated compartment is maintained at a relatively constant, elevated temperature. The radiation source, a rotatable filter wheel, a radiation detector, and a means for converting analog output to a digital signal are among the components within the insulated compartment. The non-insulated compartment houses a power supply.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 22, 2008
    Assignee: Bayer MaterialScience LLC
    Inventors: Robert N. Hunt, Atul Khettry, Matthew R. Vila
  • Publication number: 20070229830
    Abstract: A sample analyzer is disclosed that comprising: a light source section for emitting light; a first optical information acquiring section for illuminating a sample with the light emitted by the light source section, and for acquiring first optical information; and a second optical information acquiring section for illuminating a measurement specimen, to be prepared by adding a reagent to the sample, with the light emitted by the light source section, and for and acquiring second optical information. A sample analyzing method, intended for use in an automated sample analyzer, is also described.
    Type: Application
    Filed: March 30, 2007
    Publication date: October 4, 2007
    Applicant: SYSMEX CORPORATION
    Inventors: Norimasa Yamamoto, Naohiko Matsuo, Takashi Yamato
  • Patent number: 7277175
    Abstract: A system for measuring properties of small volume liquid samples, where the system includes wavelength selective filters.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: October 2, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Judith A. Thompson, John C. Kralik
  • Patent number: 7251032
    Abstract: An optical monitoring system for determining the constituents of a sample or specimen. An absorption spectrum is obtained from a sample and is passed through one or more filters having a specified absorption spectrum defined by a single atom or a compound. If the filter's absorption spectrum is included in the sample's absorption spectrum, then the sample contains that atom or compound. The apparatus includes a switching assembly that sequentially places one or more filters into the light path to determine if the subject atom or compound is contained in the sample.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: July 31, 2007
    Assignees: Neptec Optical Solutions, Inc., The University of Kentucky Research Foundation
    Inventors: Robert A. Lodder, John Carberry
  • Patent number: 6785400
    Abstract: A spray data acquisition system includes a pumping device responsive to an applied force to generate an aerosol spray plume along a spray axis. The system further includes a spray pump actuator that is capable of controlling the pumping force and the duration of the aerosol spray plume produced by the pumping device. The system also includes an illumination device that illuminates the aerosol spray plume along at least one first geometric plane that intersects the aerosol spray plume. The system further includes an imaging device that acquires data representative of an interaction between the illumination and the aerosol spray plume along at least one geometric plane.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: August 31, 2004
    Assignee: Image Therm Engineering, Inc.
    Inventor: Dino J. Farina
  • Patent number: 6561010
    Abstract: The present invention is an apparatus and method for analyzing a fluid used in a machine or in an industrial process line. The apparatus has at least one meter placed proximate the machine or process line and in contact with the machine or process fluid for measuring at least one parameter related to the fluid. The at least one parameter is a standard laboratory analysis parameter. The at least one meter includes but is not limited to viscometer, element meter, optical meter, particulate meter, and combinations thereof.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: May 13, 2003
    Assignee: Battelle Memorial Institute
    Inventors: Bary W. Wilson, Timothy J. Peters, Chester L. Shepard, James H. Reeves
  • Publication number: 20030053064
    Abstract: There are disclosed a wavelength detector capable of accurately detecting the wavelength of an entered light beam by a simple configuration without needing any highly accurate fine-adjustments, and an optical transmitter equipped with the wavelength detector.
    Type: Application
    Filed: March 15, 2002
    Publication date: March 20, 2003
    Inventors: Yasunori Nishimura, Shinichi Takagi, Masao Imaki, Yoshihito Hirano
  • Patent number: 6372184
    Abstract: A system for detecting chemical warfare agents is disclosed. The system uses a detector paper that stains upon contact with liquid chemical agent droplets and spectrophotometry technology, in cooperation with a spectral filter wheel, and a processor, to analyze the stain and determine if the stain is created by a chemical warfare agent.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: April 16, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Diane M. LaMoy, Michael A. Pompeii, Gregory P. Johnson, Jonathan A. Byrne, H. Stuart Brooks, Marc R. Carlson, Michael T. Duckett
  • Patent number: 6313917
    Abstract: A produce data collector with minimal spectral distortion. The produce data collector includes a light pipe having entrance and exit ends through which a portion of light reflected from a produce item travels, and a spectrometer adjacent the exit end of the light pipe which splits the portion of light into a plurality of wavelengths and which produces signals associated with the wavelengths for identifying the produce item.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: November 6, 2001
    Assignee: NCR Corporation
    Inventors: Hong Tang, Yeming Gu
  • Patent number: 5949549
    Abstract: A colorimeter for measuring colour of process medium comprising two light sources and two detectors both light sources being arranged to emit a beam through the process medium and the windows adjoining the process medium to both detectors. In order to achieve a solution functioning reliably the windows adjoining the process medium at both light sources are formed from a triangular prism, the two surfaces of which being at an angle to each other, are arranged to divide the beam arriving from the light source into two beams travelling in different directions so that both beams proceed to the process medium through the same part of the window surface formed by a third surface of the prism. Mirror surfaces arranged to gather radiation arriving form both light sources to a sensor of the detector are formed at both detectors.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: September 7, 1999
    Assignee: Janesko Oy
    Inventor: Ville Voipio
  • Patent number: 5825478
    Abstract: A photometer for measuring electromagnetic radiation absorption of a sample utilizing a source of the electromagnetic radiation. Electromagnetic radiation is conducted from the source, to a sample sensor or sensors, and is passed through or scattered from, the sample utilizing a sample cell. The electromagnetic radiation is then directed to a detection system which determines absorbance of electromagnetic radiation by the sample at the sample cell. The detection system includes a beam splitter which receives the electromagnetic radiation and outputs first and second beams. A first detector having a first wavelength filter and a second detector having a second wavelength filter receives the two beams from the splitters. One detector may be employed to produce a reference signal. The remaining detector or detectors produce an output signal which is a representation of a characteristic, such as absorbance of the sample.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: October 20, 1998
    Inventors: Steven Wilcox, Don S. Goldman
  • Patent number: 5822071
    Abstract: A system for normalizing measurements obtained from spectrometers to correct for measurement biases in individual spectrometers. The normalization system is adapted for use in spectrometers having an optical assembly for obtaining characteristic data from a test sample. A normalization factor is obtained in each spectrometer by placing a holographic dispersion filter between the light source and detector in the position normally occupied by the test sample, the filter having been encoded with a symbol representing a nominal value of light expected to pass through the filter. The spectrometer determines the value of light passing through the filter and calculates a normalization factor based on the ratio between the nominal value of the filter and the actual value obtained by the spectrometer. The normalization factor is stored in system memory and the filter removed so that the spectrometer may thereafter be used to evaluate a plurality of test samples.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: October 13, 1998
    Assignee: Bayer Corporation
    Inventors: Andrew J. Dosmann, Christine D. Nelson
  • Patent number: 5818575
    Abstract: Two detectors are effectively positioned at a predetermined lateral position in a rectangular illumination field at a wafer plane. The ratio of the signals from the two detectors is calculated. This ratio is indicative of the quality of the illumination field and any lamp instability which may effect the illumination field, and therefore image quality. In a photolithographic device, a short arc mercury xenon lamp provides illumination for projecting the image of a reticle onto a photosensitive resist covered substrate or wafer. The desired illumination intensity profile is sensitive to lamp instability. This instability may alter the desired illumination intensity profile which may adversely effect image quality, and therefore the resulting product. The ratio of the signals received from predetermined locations laterally along the illumination intensity profile improves the detection of unstable lamps.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: October 6, 1998
    Assignee: SVG Lithography Systems, Inc.
    Inventor: Michael A. Creighton
  • Patent number: 5754298
    Abstract: A radiant energy point source (10) generates radiant energy, and a mechanism (12, 15, 16) focuses the radiant energy generated by the point source onto a target (18) and scans the target with the focused radiant energy. A collector (16, 14) collects the focused radiant energy that is scattered from the target and a splitter (22) splits the collected radiant energy into two paths. Each of the two paths of the collected radiant energy is focused onto separate focal spots by a focusing mechanism (24). A pair of spatial filters (26, 28) filter the collected radiant energy at the focal spots. The spatial filters are offset from each other along the path of the focused radiant energy. Detectors (30, 32) separately detect the focused radiant energy which passes through each of the spatial filters and produce signals proportional to the quantity of detected focused radiant energy present.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: May 19, 1998
    Assignee: OptoMetrix, Inc.
    Inventor: Robert Aaron Falk
  • Patent number: 5739916
    Abstract: An instrument and a method are provided for determining the concentration of at least one species in a substance. The instrument and method can be used to identify and distinguish among various degrees of contamination of motor oil, diesel fuel, and hydraulic fluid by water, ethylene glycol, wear particles, and loss of anti-oxidants. The instrument includes a broad band light source, such as a tungsten filament incandescent lamp, which is very inexpensive and reliable. A fiber optic link is provided to a detector that receives and discriminates among optical spectral transmissions through the fiber optic. Discrimination circuitry is provided for evaluating the transmission and providing a readout that indicates the quality of the fluid. The instrument is suitable for in situ determination of oil quality.
    Type: Grant
    Filed: December 4, 1995
    Date of Patent: April 14, 1998
    Assignee: University of Alabama at Huntsville
    Inventor: Darell E. Englehaupt
  • Patent number: 5694206
    Abstract: A spectrophotometric system uses an immersible spectrophotometric probe that can be directly interfaced to a pH/ISE meter for calibration and read-out. The probe contains a light source, a photodetector, and interface circuitry for converting the signal from the photodetector to an output voltage within a predetermined range suitable for the pH/ISE meter (e.g., 0-1.8 volts). The probe housing can also include a sample chamber to provide a predefined optical path from the light source through a portion of the sample fluid to the photodetector. An optical filter can be included in the optical path to allow measurements within a selected wavelength range. The pH/ISE meter receives the output voltage from the probe, applies a calibration function, and displays the resulting value. In the preferred embodiment, the probe is designed as a unitary structure that is plug-compatible with most conventional pH/ISE meters.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: December 2, 1997
    Assignee: Analytical Spectral Devices, Inc.
    Inventor: Brian Curtiss
  • Patent number: 5680220
    Abstract: A first embodiment of the invention includes a light source (1) lighting two parallel optical branches (b1, b2) controlled respectively by two optical shutters (4, 6), one comprising a transparent cell (3) containing a substance to be studied, and the other being used to divert the light from the source. The light coming successively from one and from the other branch is applied selectively to three color filters (F1-F3) filtering three wavelengths selected according to the substance to be studied. The successive luminous intensities which have crossed each of the filters are measured through three detectors (D1 to D3) and the measurings are combined by means of a control (0). Analogous measuring sequences may be achieved with an embodiment comprising three light sources and a single detector. The device can be used for determination of the pH value of a substance.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: October 21, 1997
    Assignee: Institut Francais du Petrole
    Inventors: Robert Delignieres, Christian Durand
  • Patent number: 5670113
    Abstract: Automated measurement apparatus and methods for automated drug screening and for studying ion channel and cell surface receptor activity are provided. The apparatus is designed to initiate and measure rapid or transient events, such as cell receptor and/or ion channel activity. The apparatus can effect measurements of transient reactions in or more samples in a multi-well container, initiate the reaction with reagent addition and measure a resulting attribute of the sample for a period of time. The apparatus is capable of substantially continuously measuring and recording data corresponding to the measured attribute before, during and after initiation of the reaction so that a time course of the rapid or transient event is determined. Automated drug screening methods and methods for studying receptor and ion channel activity using the apparatus are also provided. The drug screening assays identify compounds that activate, inhibit or potentiate cellular ion channel or receptor activity.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: September 23, 1997
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Michael Anthony Akong, Michael Miller Harpold, Gonul Velicelebi, Paul Brust
  • Patent number: 5561527
    Abstract: Optical sensing apparatus for use with a CO.sub.2 jet spray nozzle that sprays a plume. The apparatus comprises a coherent light source that provides a light beam. A photodiode is disposed such that it detects the light beam emitted by the coherent light source that passes through the plume sprayed by the CO.sub.2 jet spray nozzle. A bandpass filter is disposed between the photodiode and the coherent light source that only passes light produced by the coherent light source. A controller coupled to the coherent light source and the photodiode that comprises a power supply for providing power to the coherent light source and the photodiode. The controller includes a digital voltmeter coupled to the photodiode for displaying a voltage output signal corresponding to the amount of light energy detected by the photodiode, and a go/no-go indicator for providing an indication of CO.sub.2 snow production.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 1, 1996
    Assignee: Hughes Aircraft Company
    Inventors: Wilfried Krone-Schmidt, Michael J. Slattery, Werner V. Brandt
  • Patent number: 5559173
    Abstract: A system for controlling the color of compounded polymer(s) comprises: a compounder for mixing the constituents of the compounded polymer(s) to produce a substantially homogeneous mixture; a sensor for measuring the color of the substantially homogeneous mixture at predetermined intervals; a colorant additive feeder, responsive to a controller, for providing the colorant additive(s) to the mixture at substantially predetermined colorant additive addition rates; and a controller, responsive to the sensor, for controlling the colorant additive addition rate(s) of the feeder.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: September 24, 1996
    Assignee: General Electric Company
    Inventors: Peter J. Campo, Paul K. Houpt
  • Patent number: 5386287
    Abstract: Device for the automatic evaluation of a plurality of test sample components, in particular within the field of water and sewage water analysis, comprising at least one chemical sensor into which the test sample component(s) is/are placed, and comprising a measuring device to determine the measurable variables which are characteristic for the test sample component(s), characterized in that each sensor is provided with a coding region for information regarding the measurable variable to be determined, and in that a reading device, for the evaluation of the coding region, and a monitoring device, which is connected to the reading device and the measuring device, are provided, wherein the monitoring device adapts the measuring device to the measurable variable to be determined on the basis of the reading supplied by the reading device.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 31, 1995
    Assignee: Dr. Bruno Lange GmbH
    Inventors: Johannes Berssen, Clemens Hanschke, Michael Kaczor, Hermann-Josef Klein, Michael Maczkowiak, Wolfgang Schmitt
  • Patent number: 5337139
    Abstract: A multichannel optical measuring system for measuring optical responses of samples illuminated by light of differing wavelengths has a plurality of measurement sample cuvettes each contain a sample to be measured. A first single light source provides a first illumination light. A plurality of sets of optical fibers direct the first illumination light from the first single light source to illuminate, along an optical axis, the samples contained in respective sample cuvettes. A second light source is provided for illuminating each respective sample cuvette with a second illumination light for measuring an intensity of transmitted light through the sample. The optical axis of the second illumination light is perpendicular to the optical axis of the first illumination light. A common photosensor disposed on the optical axis of the second light source measures the intensity of the first illumination light and the intensity of the transmitted light from each sample.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: August 9, 1994
    Assignee: Kowa Company Ltd.
    Inventor: Yoshiaki Shirasawa
  • Patent number: 5305093
    Abstract: A dual beam spectrometer for conducting both turbidimetric and colormetric measurements includes a housing with a light source. The housing further includes source exit apertures that form light from the light source into a sample light beam and reference light beam. A sample cartridge for containing sample material to be measured is mounted in the housing in the path of the sample light beam. The spectrometer also includes a detector assembly for detecting the sample light beam and the reference light beam. The detector assembly includes a first detector that senses or detects sample light beam and a second detector that senses or detects the reference light beam. A sample light beam detection aperture tube is positioned in the housing between the sample cartridge and the first detector. Similarly, a reference light beam detection aperture tube is positioned between the sample cartridge and the second detector.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: April 19, 1994
    Assignee: Miles Inc.
    Inventor: Andrew J. Dosmann
  • Patent number: 5151755
    Abstract: Defects in a measurement device are detected in a biochemical analysis apparatus wherein a droplet of liquid sample is applied to an analysis medium containing a reagent, which chemically reacts with a specific constituent in the liquid sample, the analysis medium is then incubated, the optical densities of the analysis medium are determined, and concentration of the specific constituent in the liquid sample is determined from the optical densities of the analysis media thus determined. The method for detecting defects comprises the steps of irradiating light, which has passed through a plurality of interference filters by turns, to a reference density plate, and measuring the amount of light reflected by the reference density plate. Measured values representing the amounts of reflected light, which have thus been measured for the interference filters, are compared with one another. Defects in the measurement device are detected from the results of the comparison.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: September 29, 1992
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Shunichi Seto
  • Patent number: 5128797
    Abstract: A non-mechanical optical switch is provided for alternately switching a monochromatic or quasi-monochromatic light beam along two optical paths. A polarizer polarizes light into a single, e.g., vertical component which is then rapidly modulated into vertical and horizontal components by a polarization modulator. A polarization beam splitter then reflects one of these components along one path and transmits the other along the second path. In the specific application of gas filter correlation radiometry, one path is directed through a vacuum cell and one path is directed through a gas correlation cell containing a desired gas. Reflecting mirrors cause these two paths to intersect at a second polarization beam splitter which reflects one component and transmits the other to recombine them into a polarization modulated beam which can be detected by an appropriate single sensor.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: July 7, 1992
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Glen W. Sachse, Liang-Guo Wang
  • Patent number: 5125748
    Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: June 30, 1992
    Assignee: Beckman Instruments, Inc.
    Inventors: Torleif O. Bjornson, R. Fred Pfost
  • Patent number: 5125747
    Abstract: Optical analytical instruments to determine a physical parameter of a fluid, and methods of operation of such instruments, are shown. These employ a source of suitable optical radiation, a detector means, means defining a zone for the fluid, means defining an optical path from the radiation source through the fluid zone to the detector means, and reading and control circuitry. At least two readings of optical energy that has been influenced by the fluid are taken without there having occurred substantial change to the fluid. During one of the readings a filter of known absorbance is included in the optical path so that the respective reading represents a calibration reading.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: June 30, 1992
    Assignee: Tytronics, Inc.
    Inventors: Emile Sayegh, Eric F. Mooney
  • Patent number: 5092677
    Abstract: An apparatus and method for making a photometric determination regarding the contents of a sample, such as the absorbance characteristic of a blood serum sample. The improvement allows measurements to be taken after a reduced warm-up period and compensates for variations in the lamp intensity during the period over which measurements are taken. A feedback circuit is provided between a reference photodetector and the light source for causing the light source intensity to asymptotically approach a final stable value in a smooth exponential curve. Signal processing means processes outputs of the reference and sample photodetectors taken at different times so as to compensate for variations in the source intensity over the time period during which the outputs are taken. Still further, the photometer allows resonant frequency mixing of the contents of a cuvette while disposed in the photometer by causing the entire optical assembly, in which the cuvette is mounted, to vibrate at its resonant frequency.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: March 3, 1992
    Assignee: Artel, Inc.
    Inventor: Richard Curtis