Abstract: A system including one or more waveguides to receive a first returned reflection having a first lag angle and generate a first waveguide signal, receive a second returned reflection having a second lag angle different from the first lag angle, and generate a second waveguide signal. The system includes one or more photodetectors to generate a first output signal within a first frequency range, and generate, based on the second waveguide signal and a second LO signal, a second output signal within a second frequency range. The system includes an optical frequency shifter (OFS) to shift a frequency of the second LO signal to cause the second output signal to shift from within the second frequency range to within the first frequency range to generate a shifted signal. The system includes a processor to receive the shifted signal to produce one or more points in a point set.

Abstract: A light detection device includes: a first support part disposed on a mounting surface of the wiring board; a Fabry-Perot interference filter disposed in a first support region of the first support part; and a temperature detector, wherein the temperature detector is disposed on the mounting surface such that at least a part of the temperature detector overlaps a part of the Fabry-Perot interference filter when seen in a first direction perpendicular to the mounting surface and such that at least a part of the temperature detector overlaps a part of the first support part when seen in a second direction in which the first support part and the light detector are aligned with each other, and wherein a first distance between the temperature detector and the first support part in the second direction is smaller than a first width of the first support region in the second direction.

Abstract: Provided are systems and methods that allow for brightfield imaging in a flow cytometer, allowing for collection of fluorescence and high-quality image date. The disclosed technology also gives rise to an illumination pattern that allows a user to create different oblique or structured illumination profiles within a static system. With the disclosed approach, a user can illuminate a sample from a first direction (e.g., with laser illumination configured to give rise to one or more of fluorescence information and scattering information), collect scattering information from a second direction, collect fluorescence information from a third direction, and capture an image of the sample from a fourth direction. (Two or more of the foregoing can be accomplished simultaneously.) Also as described elsewhere herein, an illumination used to illuminate the sample for visual image capture can be communicated to the same through a lens that also collects fluorescence from the sample.

Abstract: Arrangement for acquiring images for producing a head related transfer function filter is disclosed. In the arrangement the camera of a mobile phone or similar portable device is adjusted for the imaging. All acquired images are analyzed and only suitable images are sent further for producing the head related transfer filter. The arrangement is further configured to provide instructions to the user so that the whole head and other relevant body parts are sufficiently covered.

Abstract: The invention relates to a method for determining a position of an object, which comprises at least one non-linear component, in particular one semiconductor component, which, when irradiated with high-frequency transmitted signals from at least two different positions, produces and emits object signals having twice and/or three times the frequency of the respective transmitted signals.

Abstract: A light detection and ranging (LIDAR) transceiver includes optical antenna arrays and an optical switch. Some of the optical antenna arrays include a number of optical antennas and an optical splitter coupled to the optical antennas. The optical splitter may include a number of passive optical splitters. The optical splitter provides a portion of an input signal to the optical antennas. The optical switch is configured to selectively provide the input signal to at least one of the plurality of optical antenna arrays. The optical switch enables addressable field of view scanning by selectively providing the input signal to the plurality of antenna arrays, one array at a time.

Abstract: In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled to the second coupler via an optical waveguide that induces a delay at least equal to an acquisition time of an image sensor; and an output coupled to the image sensor.

Abstract: The present disclosure relates to devices, systems and methods for extracting physiological information indicative of at least one vital sign of a subject. An embodiment of a device comprises a pre-treatment unit configured to derive at least three detection signals from electromagnetic radiation reflected from a skin region of a subject, wherein at least two detection signals comprise wavelength-dependent reflection information in a different wavelength channel and at least two detection signals comprise reflection information in different polarization channels having different polarization directions.

Abstract: A gaming machine includes at least one image sensor for capturing an image including a player area associated with the gaming machine and logic circuitry in communication with the image sensor. The logic circuitry establishes a facial image mask defining an area of interest within the player area, receives the captured image from the image sensor, applies the facial image mask to the captured image to extract player image data from the captured image data, detects any faces within the player image data, compares, in response to detecting a face of a player within the player image data, the detected face with a player database to identify a player account associated with the player, and links, in response to identifying a matching player account based on the comparison, the matching player account to activities of the player at the gaming machine.

Abstract: An architecture for a chip-scale optical phased array-based scanning frequency-modulated continuous wave (FMCW) Light-detection and ranging (LiDAR) device is described. The LiDAR device includes a laser, a transmit optical splitter, an optical circulator, photodetectors, and an optical phased array. The laser, the transmit optical splitter, the optical circulator, the photodetectors, and the optical phased array are arranged as a chip-scale package on a single semiconductor substrate. The laser generates a first light beam that is transmitted to the optical phased array aperture via the transmit optical splitter, the optical circulator, and the optical phased array. A fraction of the first light beam is transmitted to the photodetectors via the transmit optical splitter to serve as the optical local oscillator (LO), the aperture of the optical phased array captures a second light beam that is transmitted to the photodetectors via the optical phased array and the optical circulator.

Abstract: An ophthalmic device includes a two-dimensional image acquisition unit that acquires a two-dimensional image by photographing the front of an eye to be examined with a color camera; a three-dimensional image acquisition unit that acquires a three-dimensional image of the eye to be examined by optical coherence tomography; and a correspondence definition data generation unit that generates correspondence definition data in which the position of a predetermined site of the eye to be examined in the three-dimensional image when the predetermined site is photographed as the three-dimensional image is associated with the position of the predetermined site in the two-dimensional image when the predetermined site is photographed as the two-dimensional image.

Abstract: An ophthalmic device includes a two-dimensional image acquisition unit that acquires a two-dimensional image by photographing the front of an eye to be examined with a color camera; a three-dimensional image acquisition unit that acquires a three-dimensional image of the eye to be examined by optical coherence tomography; and a correspondence definition data generation unit that generates correspondence definition data in which the position of a predetermined site of the eye to be examined in the three-dimensional image when the predetermined site is photographed as the three-dimensional image is associated with the position of the predetermined site in the two-dimensional image when the predetermined site is photographed as the two-dimensional image.

Abstract: A vacuum device comprises a vacuum generator and a vacuum interface for fluidically coupling the vacuum generator to a vacuum cavity for affixing an ophthalmological patient interface on a patient's eye. The vacuum device comprises a movement detector which is configured to detect movements of the patient's eye and a control unit that is configured to detect a faulty fluidic coupling of the vacuum cavity on the basis of a pressure that is ascertained by a coupled pressure sensor and to produce a control signal for interrupting an ophthalmological treatment that is carried out by an ophthalmological treatment device if an eye movement is detected by the movement detector at the same time as the detected faulty fluidic coupling of the vacuum cavity.

Abstract: An OCT apparatus and method for characterization of a fluid adjacent to a tympanic membrane has a low coherence source which is coupled to a splitter which has a measurement path and a reference path. The reference path is temporally modulated for length, and the combined signals from the reference path and the measurement path are applied to a detector. The detector examines the width of the response and the time variation when an optional excitation source is applied to the tympanic membrane, the width of the response and the time variation forming a metric indicating the viscosity of a fluid adjacent to the tympanic membrane being measured.

Abstract: An optical coherence tomography (OCT) engine includes a digital Fourier-Transform (dFT) spectrometer, a tunable delay line, and a high-speed optical phased array (OPA) scanner integrated onto a single chip. The broadband dFT spectrometer offers superior signal-to-noise ratio (SNR) and fine axial resolution; the tunable delay line ensures large imaging depth by circumventing sensitivity roll-off; and the OPA can scan the beams at GHz rates without moving parts. Unlike conventional spectrometers, the dFT spectrometer employs an optical switch network to retrieve spectral information in an exponentially scaling fashion—its performance doubles with every new optical switch added to the network. Moreover, it also benefits from the Fellgett's advantage, which provide a significant SNR edge over conventional spectrometers. The tunable delay line balances the path length difference between the reference and sample arms, avoiding any need to sample high-frequency spectral fringes.

Abstract: A method for monitoring a property of nanoparticles in a flowing suspension comprises providing a sample comprising a flowing suspension. The method further comprises non-invasively monitoring a size distribution of nanoparticles of the flowing suspension using Fourier domain low-coherence interferometry, FDLCI, wherein the monitoring comprises deriving a time and optical path length resolved LCI light scattering signal l(t,z) from time resolved LCI wavelength spectra of interference and deriving information indicative of the size of the particles in the sample based on said time and optical path length resolved LCI light scattering signal using optical path length resolved temporal autocorrelation functions or optical path length resolved frequency power spectra of the spatiotemporal FDLCI signal.

Abstract: Disclosed is an optical coherence tomography (OCT) system according to an exemplary embodiment of the present disclosure.

Abstract: A method for mitigating modal noise includes applying a time-varying mechanical force to a fiber segment of the multimode optical fiber in at least a first direction orthogonal to a fiber axis of the multimode optical fiber within the fiber segment. A modal-noise mitigator for a multimode optical fiber includes an actuator configured to apply a time-varying mechanical force to a fiber segment of the multimode optical fiber in at least a first direction orthogonal to a fiber axis of the multimode optical fiber within the fiber segment.

Abstract: An exemplary system for generating an image(s) of a sample(s) can include, for example, an imaging arrangement that can include a superluminescent diode (SLD) configured to generate a radiation(s) to be provided to the sample(s), and a spectrometer configured to (i) sample an A-line sampling rate of at least about 200 kHz, (ii) receive a resultant radiation from the sample(s) based on the sampling rate, and (iii) generate information based on the resultant radiation, and a computer hardware arrangement configured to generate the image(s) of the sample(s) based on the information received from the spectrometer. The imaging arrangement can be an interferometric imaging arrangement, which can be an optical coherence tomography imaging (OCT) arrangement. The computer hardware arrangement can be further configured to facilitate a plurality of b-scan acquisitions of the sample(s) and facilitate the b-scan acquisitions in order to generate the image(s).

Abstract: Disclosed herein is a method for depth-profiling of samples including a target region including a lateral structural feature. The method includes obtaining measured signals of the sample and analyzing thereof to obtain a depth-dependence of at least one parameter characterizing the lateral structural feature. The measured signals are obtained by repeatedly: projecting a pump pulse on the sample, thereby producing an acoustic pulse propagating within the target region; Brillouin-scattering a probe pulse off the acoustic pulse within the target region; and detecting a scattered component of the probe pulse to obtain a measured signal. In each repetition the respective probe pulse is scattered off the acoustic pulse at a respective depth within the target region, thereby probing the target region at a plurality of depths. A wavelength of the pump pulse is at least about two times greater than a lateral extent of the lateral structural feature.

Abstract: There is provided an image processing device for observing an inside of an eye in a wider range. The image processing device includes an integration processing unit that integrates ophthalmologic images acquired by a plurality of types of ophthalmologic image capturing devices by correlating intraocular positions and generates one integrated image indicating intraocular information in a range wider than a range indicated by each of the ophthalmologic images.

Abstract: A photonic circulator deployed on a chip-scale light-detection and ranging (LiDAR) device includes a first arm that includes a first waveguide that is bonded onto a first member at a first bonding region, and a second arm that includes a second waveguide that is bonded onto a second member at a second bonding region. A first thermo-optic phase shifter is arranged on the first member and collocated with the first waveguide, and a second thermo-optic phase shifter is arranged on the second member and collocated with the second waveguide. The magneto-optic material and the first thermo-optic phase shifter of the first member cause a first phase shift in a first light beam travelling through the first waveguide, and the magneto-optic material and the second thermo-optic phase shifter of the second member cause a second phase shift in a second light beam travelling through the second waveguide.

Abstract: An optical coherence tomography (OCT) system (63) is used to inspect bonding points (66A, 66B, 66C) sandwiched between two materials (layers 62, 64 of e.g. displays). The OCT differentiates between a bonding point, e.g. a weld, and air gaps between the two materials. The bonding points are identified as breaks in the air gap between the materials. By extracting various physical characteristics of the bonding points and the gap between the two materials, the present system determines whether the bonding is faulty.

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

Abstract: A signal control module integrated to a low coherence interferometry including a one-dimensional (1D) array image sensor is provided. The signal control module includes an image acquisition controller and a signal controller. The image acquisition controller sends a 1D image acquisition control signal. The signal controller sends a two-dimensional (2D) image acquisition control signal, wherein the 1D and 2D image acquisition control signals are synchronized with each other. The 1D array image sensor captures 1D image information of an object-to-be-tested at different positions along a direction according to the 1D and 2D image acquisition control signals. The 1D image information constitutes 2D image information. Furthermore, a low coherence interferometry is provided.

Abstract: A method of measuring working distance between a handheld digital device and eyes of a user, including capturing an image of at least eyes of a user via an onboard camera of the handheld digital device while the user is viewing a display of the handheld digital device and comparing an apparent angular size of a structure of the eyes or face of the user to a previously captured image of the structure of the eyes or the face that was taken in the presence of an object of known size. The method further includes calculating a working distance based on the apparent angular size of the structure of the eyes or the face; and saving at least the working distance to memory or reporting out the calculated working distance on the display. A handheld digital device programmed with an algorithm to perform the method is also included.

Abstract: The technology disclosed in this patent document can be used to implement an optical coherent tomography (OCT) system that combines a control of the probe light to the target sample with different optical aberration patterns in optically probing the target sample and an OCT imaging processing to enhance the OCT imaging quality by combining image signals from in-phase contributions from the probing with different optical aberration patterns while suppressing randomly phased contributions from scattering by the target sample.

Abstract: One or more devices, systems, methods and storage mediums for performing common path optical coherence tomography (OCT) with a controlled reference signal and efficient geometric coupling are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes (e.g., common path probes), common path catheters, common path capsules and common path needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a reference reflection or a reference plane that is at least one of: (i) disposed in the collimation field or path; and (ii) is perpendicular (or normal) or substantially perpendicular (or substantially normal) to light propagation.

Abstract: A method for determining a retardance of a layer of a sample. The method includes: transmitting a first portion of a polarized light to a sample arm of an optical system and a second portion of the polarized light to a reference arm of the optical system; combining first return light returned from the sample arm and second return light from the reference arm; detecting, using a detector, the combined light along a first polarization state and a second polarization state to produce polarization data, the second polarization state being different from the first polarization state; determining, using a processor coupled to the detector, polarization states of light returning from upper and lower surfaces of a layer of the sample based on detecting the combined light; and determining, using the processor, a retardance of the layer of the sample based on the determined polarization states.

Abstract: According to a first aspect, the present disclosure relates to a digital holography device (100) for full-field blood flow imaging of ocular vessels of a field of view of a layer (11) of the eye (10). The device comprises an optical source (101) configured for the generation of an illuminating beam (Eobj) and a reference beam (ELO), and a detector (135) configured to acquire a plurality of interferograms (I(x,y,t)) wherein an interferogram is defined as the signal resulting from the interference between the said reference beam (ELO) and a part of said illuminating beam (Eobj) that is backscattered from said layer (11).

Abstract: Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulate out of the respiratory system. The ciliary beating frequency (CBF) is often disrupted with the onset of disease. Current imaging of ciliary motion relies on microscopy and high speed cameras, which cannot be easily adapted to in-vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited. The present invention features the development of a spectrally encoded interferometric microscopy (SEIM) system using a phase-resolved Doppler (PRD) algorithm to measure and map the ciliary beating frequency within an on face region. This novel high speed, high resolution system allows for visualization of both temporal and spatial ciliary motion patterns.

Abstract: A detector for characterizing at least one of a middle ear fluid and a middle ear biofilm includes a handheld probe outputting near-infrared and visible light, an OCT system to obtain A-scans at a plurality of positions on a tympanic membrane, and a camera to obtain surface sub-images at the plurality of positions. A-scans and surface sub-images are synchronized and the surface sub-images are mosaicked to generate a surface image of the tympanic membrane. Cross-sectional scan images or a thickness map are generated from the synchronized A-scans and segmented to extract a plurality of specified features. The specified features are then classified to characterize at least one of the middle ear fluid and the middle ear biofilm. The detector, including handheld probe with camera, OCT system, and a laptop computer, is sized to fit into a handheld, portable, compact, foam-padded briefcase weighing less than 10 kg.

Abstract: A distance measurement device includes an imaging optical system, an imaging device, and a distance measurement section which measures based on a plurality of images captured by the imaging device, a distance from the imaging device to the target to be imaged. The imaging optical system includes a polarization beam splitting section which splits a first polarization beam having a first polarization direction and a second polarization beam having a second polarization direction substantially orthogonal to the first polarization direction and allows the polarization beam splitting section to be incident on the imaging device. The imaging device receives the first polarization beam to capture a first polarization image and the second polarization beam to capture a second polarization image. The distance measurement section measures the distance to the target to be imaged on the basis of the first polarization image and the second polarization image.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: A digitizer and processor device for a swept-source optical coherence tomography (SS-OCT) imaging system, comprising: an input configured to receive an OCT signal; a control input configured to receive a k-clock signal; a combiner unit (130) receiving the OCT signal and the k-clock signal configured to output a composite signal; a digitizing unit (60) arranged to convert the composite signal into a digital composite signal (69); a data processing unit (70) arranged to determine a profile of optical density in a sample that generated the OCT signal based on the digital composite signal (69).

Abstract: A LIDAR system includes optics that generate a light signal that carries LIDAR data that indicates a distance and/or radial velocity between the optics and an object located outside of the LIDAR system. Electronics are configured to convert the light signal to a first data electrical signal and a second data electrical signal. The electronics perform a Complex Fourier transform on a complex signal such that the first data electrical signals acts a real component of the complex signal and the second data electrical signals acts as an imaginary component of the complex signal. The electronics determine the LIDAR data from an output of the Complex Fourier transform.

Abstract: Described herein is an optical coherence tomograph (OCT) angiography technique based on the comparison of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan flow values can be determined using the individual spectral bands separately and then averaged. Recombining the flow images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.

Abstract: The present disclosure relates to an optical waveguide system. The system has a first waveguide having a core-guide and a cladding material portion surrounding and encasing the core-guide to form a substantially D-shaped cross sectional profile with an exposed flat section running along a length thereof. The core-guide enables a core-guide mode for an optical pulse signal having a first characteristic, travelling through the core-guide. A material layer of non-linear material is used which forms a second waveguide. The material layer is disposed on the exposed flat section of the cladding material portion. The material layer forms a plasmonic device to achieve a desired coupling with the core-guide to couple optical energy travelling through the core-guide into the material layer to modify the optical energy travelling through the core-guide such that the optical energy travelling through the core-guide has a second characteristic different from the first characteristic.

Abstract: The disclosure relates to stent detection and shadow detection in the context of intravascular data sets obtained using a probe such as, for example, and optical coherence tomography probe or an intravascular ultrasound probe.

Abstract: A distance measuring sensor includes: a light source having a semiconductor optical amplifier and a resonator with a silicon photonic circuit, which are at a semiconductor substrate; a plurality of emitters, each emitter configured to emit a light beam generated by the light source to outside of the light source; a scanner configured to perform scanning with the light beam by enabling the light beam emitted from the light source to be reflected at a mirror and vibrating the mirror; an optical receiver configured to receive a reflected light beam, which is generated by the light beam reflected at the object; and a processor configured to measure the distance to the object based on the reflected light beam received at the optical receiver. Light beams respectively emitted from the emitters are incident on the mirror in different directions. The scanner performs scanning different regions with the respective light beams.

Abstract: A digital measuring device implemented on a photonic integrated circuit, the digital measuring device including a tunable laser source implemented on the photonic integrated circuit configured to sweep over a frequency range to provide multi-wavelength light, a first waveguide structure implemented on the photonic integrated circuit configured to direct a first portion of light from the laser source at a moving object and receive light reflected from the moving object, a second waveguide structure implemented on the photonic integrated circuit configured to combine a second portion of light from the laser source with the light reflected from the moving object to produce a measurement beam, and a first detector implemented on the photonic integrated circuit configured to detect intensity values of the measurement beam to measure a distance between the digital measuring device and the moving object.

Abstract: Methods and systems for focusing and measuring by mean of an interferometer device, having an optical coherence tomography (OCT) focusing system, by separately directing an overlapped measurement and reference wavefront towards a focus sensor and towards an imaging sensor; where a predefined focusing illumination spectrum of the overlapped wavefront is directed towards the focus sensor, and where a predefined measurement illumination spectrum of the overlapped wavefront is directed towards the imaging sensor. Methods and systems for maintaining focus of an interferometer device, having an OCT focusing system, during sample's stage moves.

Abstract: Disclosed is a device and a method for measuring Fabry-Parot (FP) transmittance curve by using a whispering gallery mode laser source. The device includes: a seed laser, a first polarizer, a second polarizer, a spectroscope, a beam reduction system, a lens, and Polydimethylsiloxane (PDMS) microfluidic chip arranged in sequence.

Abstract: Methods, devices and systems are described that use a combination multiple light sources having different coherence lengths to measure surface characteristics of an object. One example system includes a two laser sources configured to operate at a first and a second center wavelength, a broadband source configured to operate at a range of wavelengths outside of the operating range of the at least two lasers, a phase mask array and a color filter arranged, respectively, to impart different phase delays and provide spectral filtering corresponding to the emitted radiation from the sources. A pixelated sensor device is positioned to simultaneously measure intensity values associated with a plurality of interferograms formed due to interference of light from the light sources after propagation through the phase mask array and the color filter. The measured intensity values enable the determination of surface characteristics of the object.

Abstract: In some embodiments, a SCAPE system routes light from a tilted intermediate image plane to an infinity space disposed behind a third objective. A first beam splitter positioned in the infinity space routes light from the intermediate image plane with different wavelengths in different directions. First and second light detector arrays capture first and second wavelength images, respectively, and optical components route light having the first and second wavelength towards the first and second light detectors, respectively. In some embodiments, a SCAPE system is used to capture a plurality of images while a sample is perturbed (e.g., vibrated, deformed, pushed, pulled, stretched, or squeezed) in order to visualize the impact of the perturbation on the sample.

Abstract: Systems and methods for dynamic locking of optical path times using entangled photons are provided. A system includes an optical source for generating bi-photons; tracer laser beam sources for generating tracer laser beams; telescopes that emit the tracer laser beams and the bi-photons to remote reflectors, each bi-photon traveling along an optical path in a pair of optical paths toward a corresponding remote reflector, wherein the telescopes receive reflected bi-photons from the remote reflectors; and communication links, wherein the optical source respectively communicates with first and second remote reflectors through a first and second communication link. Also, the optical source uses the tracer laser beams and the communication links to respectively point the bi-photons towards the remote reflectors.

Abstract: An optical coherence tomographic (OCT) system includes a sample arm, a reference arm and an OCT probe. The probe irradiates a bodily lumen and a fluid contained within the bodily lumen with light of a sample beam transmitted through a double-clad fiber (DCF). A first detector detects light of a reference beam and light reflected from the bodily lumen and propagated through the core of the DCF to generate OCT interference signals. Light backscattered by the bodily lumen and by the fluid contained in the bodily lumen is propagated through a cladding of the DCF and detected by a second detector to generate an intensity signal. A processor analyzes the intensity signal, and triggers a pullback of the probe and initiates recording of OCT images of the bodily lumen in response to the intensity the backscattered light reaching a predetermined threshold value.

Abstract: An OCT imaging method of some exemplary aspects includes acquiring a first three dimensional data set by applying an OCT scan targeting a first three dimensional region of a sample, creating a first two dimensional map based on representative intensity values respectively of a plurality of pieces of A-scan data included in the first three dimensional data set, designating a second three dimensional region of the sample based on the first two dimensional map, acquiring a second three dimensional data set by applying an OCT scan targeting the second three dimensional region, and generating image data from at least part of the second three dimensional data set.

Abstract: A non-invasive optical detection system and method are provided. Sample light is delivered into a target volume of interest, whereby the sample light is scattered by the target volume of interest, resulting in a sample light pattern that exits the anatomical structure. Reference light is combined with the sample light pattern to generate at least one interference light pattern, each of which may have a time varying interference component that integrates to a first value in the absence of the physiological event, and that integrates to a second greater value in the presence of the physiological event. Intensities of spatial components of each interference light pattern are detected during a measurement period. A function of the detected spatial component intensities of the interference light pattern(s) is analyzed, and a presence of the physiological event in the target volume of interest is determined based on the analysis.

Abstract: A system includes a laser (1) operative to emit a light beam, a beam splitter (2) arranged to split the light beam into a first beam and a second beam, the first beam being directed to a nonlinear converter (8) that generates a signal beam having a Stokes-shifted wavelength, a recombiner (9) arranged to recombine the signal beam with the second beam to form a recombined beam which is directed to a tapered optical fiber (5) located within a material to be monitored, and a detector (7) arranged to detect light emitted by the tapered optical fiber (5) and which uses stimulated Raman spectroscopy to detect a chemical in the material.