Abstract: The present invention relates to a holder for at least one capture device (30) for collecting microdissected specimens, having a holding element (2) in which the at least one capture device (30) is to be arranged, the holding element (2) being transferable into a working position in order to collect microdissected specimens, the holding element (2) being mounted by way of at least two levers (3a, 3b) in a frame (1) of the holder (40), and being vertically displaceable relative to said frame (1) by way of a displacement of the levers (3a, 3b).

Abstract: The present invention relates to a portable digital reader for urinalysis. The portable digital reader for reading an analysis target chip including a plurality of test areas, comprises: a main body including a light emitting section having light emitting elements for radiating light, an integral optical splitter for uniformly distributing the light from the light emitting section to each test area of the analysis target chip, a light receiving section for receiving light reflected from the each test area so as to convert the same to electric signals, and a measuring section for measuring concentration according to the electric signals obtained from the light receiving section; a main supporting body having the analysis target chip and assembled with the main body; and an auxiliary supporting body assembled between the analysis target chip and the main supporting body, including a groove for assembling the analysis target chip, and assembled with the main supporting body to be exchanged after use.

Abstract: A slide stainer and a method for operating the slide carrier is disclosed. The slide stainer includes a slide carrier that carries one or more laboratory slides; a vessel that is capable of carrying fluid for staining the laboratory slides and that is sized to accommodate the laboratory slides; a slide transporter that moves the slide carrier into and out of the vessel; and a spring loaded pin that engages with a surface of the slide stainer to limit free-fall translation of the slide carrier in an event of a power loss. Additionally, during an agitation phase of a slide staining process, the slide transporter is configured to translate the slide carrier in an upward direction to a pre-determined height that is set by a user of the slide stainer, and the slide transporter translates the slide carrier in a downward direction back into the vessel.

Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package includes a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.

Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.

Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.

Abstract: An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.

Abstract: An apparatus for processing a biological sample is provided, the biological sample being arranged on a first planar surface of a carrier. The apparatus comprises a second planar surface arranged substantially parallel to said first planar surface and at a first distance from said first planar surface, said first planar surface and said second planar surface being arranged at an angle (A) greater than zero degree from the horizontal plane (HP); and supply means for supplying an amount of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.

Abstract: A dispensing apparatus includes: a dish mounting portion having a mounting surface mounted with a dish having a bottom surface and a side surface surrounding the bottom surface; a syringe, arranged above the dish mounting portion, having a nozzle configured to discharge liquid toward an interior of the dish; and a first driving portion configured to change the syringe in direction with respect to a first axis as a center, wherein the first axis is orthogonal to a normal to the mounting surface of the dish mounting portion.

Abstract: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator.

Abstract: An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides.

Abstract: A slide holder comprising a rectangular frame having two side walls facing each other, a first end wall facing a second end wall, the second end wall having a latch pivotally attached thereto, the latch capable of being pivoted in such a manner as to enable locking and unlocking of the slide holder in a slide holder carrier. The slide holder carrier has a first end wall, a first side wall, a second end wall, a second side wall, and a shaft running from the first end wall of the slide holder carrier to the second end wall of the slide holder carrier. At least one slide holder is rotatably mounted on the shaft.

Abstract: An apparatus (10) for handling specimen slides (32, 78, 80) has at least one coverslipping module (14) for coverslipping thin sections arranged on specimen slides (32, 78, 80). The apparatus (10) further encompasses a drying unit (16, 70, 90) for extracting solvent from the mounting medium applied onto the specimen slides (32, 78, 80). The drying unit (16, 70, 90) has an air delivery unit (40) for delivering an air flow to the specimen slides (32, 78, 80).

Abstract: A disclosed substrate processing apparatus comprises a heat exchange plate configured to heat and/or cool the substrate; plural protrusions provided on the heat exchange plate so as to allow the substrate to be placed on the plural protrusions, leaving a gap between the substrate and the heat exchange plate; a suction portion configured to attract the substrate onto the plural protrusion by suction through plural holes formed in the heat exchange plate; and a partition member that is provided on the heat exchange plate and lower than the plural protrusions, wherein the partition member is configured to divide the gap into two or more regions including at least one of the holes so that at least one of the two or more regions is two-dimensionally closed by the partition member.

Abstract: To provide a specimen transporter that can be suitably used by being connected to a specimen imaging apparatus that does not have a function of collecting an imaged specimen plate.

Abstract: To provide a specimen storage device capable of preventing liquid such as immersion oil and the like attached to the specimen plate from leaking to the outside of the rack and capable of enhancing the operation efficiency by automating the supply and discharge of the rack. Provided is a specimen storage device which stores a imaged specimen plate in a bottomed-shaped rack having an opening at an upper part, the specimen storage device including a rack transport mechanism which transports the rack with the opening directed upward, and a specimen transport mechanism which transports the specimen in an up-down direction, wherein the rack transport mechanism transports the rack to a predetermined specimen storage position, and the specimen transport mechanism stores the specimen to the rack positioned at the specimen storage position from above the rack.

Abstract: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises an assembly of vessels (4) for receiving different liquids for staining of the tissue specimens, a loading station (2) for microscope slides (28), a conveyor (5) for transfer of carriers with microscope slides from vessel to vessel in accordance with a treatment program, an unloading station (8) for treated microscope slides, and a control unit (18) for controlling the treatment operations in accordance with a data program. The apparatus comprises different levels (I, II) having units for execution of the relevant treatment operations.

Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.

Abstract: An automatically operating apparatus designed as a table-top apparatus for the reproducible production of cell or tissue samples to be examined and arranged on specimen slides comprises, located its center, a rotatably supported, advance device having arranged on its periphery a plurality of modular processing stations at a distance from the advance device. Receiving devices provided in the peripheral region of the advance device are disposed to receive specimen slides on which automatically segmented cell and tissue segments can be positioned in a reproducible and correctly aligned manner. The cell and tissue segments are durably fixed in position on the specimen slides with the use of a curable adhesive, and the specimen slides, after being delivered, are subjected to further treatment processes in a further treatment device.

Abstract: A sample presentation apparatus comprises a round support movable in an optical assembly and having a flange region and an elevated gear shaped region having indexing gear cogs at intermediate radius locations of the support; a sample carrier slide holder removably supported on and movable with the support, the slide holder having at least one arm extending radially from a central hub of the sample carrier slide holder and being aligned between a first pair of indexing gear cogs; and at least one sample carrier slide removably supported on the support and aligned by the first pair of indexing gear cogs. In another embodiment of the invention, a self-aligning movable platform and support apparatus in an optical assembly comprises coarse and fine alignment mechanisms.

Abstract: A sensor module (38, 40, 42) for a tissue processor (20) has a thermal sensor (66) for measuring a temperature of a container (30, 32, 34) of the tissue processor (20), and further has a position sensor for detecting a working position of the container (30, 32, 34).

Abstract: A stack of test strips comprises individual test strips which are stacked over each other and carry a test field for examining a bodily fluid sample. Test strips lying one on top of the other are detachably adhesively bonded to each other so that the test strips can be individually removed from the stack, wherein the test fields are packed in chambers and adjacent test strips form the bottom and the lid of such a chamber. A method for producing such a stack of test strips is also disclosed.

Abstract: A retaining clip for retaining reagent test slides in a stacked arrangement is formed as a unitary member and has first, second and third plates, each having an inner surface and an outer surface. The inner surface of the first plate pivots towards the inner surface of the second plate, and the inner surface of the third plate also pivots such that the inner surfaces of the first and third plates at least partially face each other upon pivoting. The inner surfaces of the first and third plates are separated by a distance to accommodate the reagent test slides in a stacked arrangement. Alternatively, the third and second plates can be fixed rigidly to each other with only the first plate pivoting to at least partially face the third plate upon pivoting.

Abstract: The disclosure relates to a retainer (100) for sample carriers (P1-P4) of different shapes and sizes. The retainer includes a retaining plane (110) for receiving the sample carrier; at least three respectively movably mounted stop elements (120), each of the stop elements (120) having at least one stop surface (121) which is embodied to be adjusted, by movement of the stop element (120), against the sample carrier (P1-P4); at least three securing elements (125), a securing element (125) being associated with each of the at least three stop elements (120); each of the at least three securing elements (125) configured to secure the associated stop element (120) immovably on the retainer, and configured to be conveyable into a first position in which the associated stop element (120) is movable, and to be conveyable into a second position in which the associated stop element is secured immovably on the retainer.

Abstract: The present invention relates generally to the field of analysis, for example biological analysis.

Abstract: An automatic slide loading device for microarray scanner comprises slide holders (1), a carrier device (2) and a positioning chamber (3), wherein the slide holder (1) can hold microarray slides (6) and the slide holder (1) is placed out of the scanning platform of the microarray scanner when the microarray scanner is in off work state, wherein the carrier device (2) is connected to the positioning chamber (3) and the carrier device (2) can load the slide holder (1) into the positioning chamber (3), wherein the positioning chamber (3) is placed above the scanning platform of the microarray scanner and is used to precisely locate the working surface of the microarray slides (6) in the slide holder (1).

Abstract: A portable temperature transfer stand for holding thermo-conductive laboratory devices transferring thermal energy to laboratory devices is provided as well as its methods of use. The temperature transfer stand comprises at least one supporting structure (foot) and a stable stage, both comprising a thermal conductive material. The supporting structure is in direct contact with the stage which is in direct contact with a laboratory device.

Abstract: The device comprises a support in the form of a tray or the like, which is at the top and provided inside with first grooves for guiding first cards arranged parallel to each other, forming a single level for the cards and is characterized in that it has sets of grooves interposed between the first grooves, allowing a second level of cards to be placed at a level higher than the first cards.

Abstract: A method applying a biological specimen to an analytic plate by using an applicator device to apply a coating to the analytic plate and adhering the biological sample to the plate. The coating is substantially transparent, translucent or invisible, and is substantially flush with the surface of the analytic plate. The coating is preferably comprised of a polysiloxane, siloxane, silicone, a silane, a silicon fluid, or a combination thereof and optionally an acid.

Abstract: Methods and devices for the thermal processing of samples are disclosed, including portable, integrated processing assemblies for occluding channels in a fluidic device.

Abstract: A slide holder assembly and method for use in high content screening of a comet assay. The slide holder assembly has an inside surface and is configured to receive a slide holding a plurality of biological cells on a top surface thereof. When the slide is secured within the slide holder assembly, the inside surface of the slide holder assembly and the top surface of the slide combine to form a cavity having an open top end. The cavity is watertight and configured to hold a liquid therein. A method of performing a comet assay using a slide disposed within a slide holder assembly. The method includes performing encapsulation, lysis, electrophoresis, staining, and imaging of cells on the slide while the slide remains secured within the slide holder assembly.

Abstract: A biochip holder is disclosed, the holder including a means to receive a biochip, a vacuum port in communication with the received biochip, and a vacuum source connected to the vacuum port. Liquid from flushing of the biochip is pulled by vacuum force into a vacuum port and can be collected in order to prevent cross-contamination of the biochip. A method of collecting fluid from such a biochip is also disclosed.

Abstract: A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity.

Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.

Abstract: A portable temperature transfer device for transferring thermo energy to and/or from a laboratory culture plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material. The raised stage allows direct contact between individual wells of the laboratory culture plate and the temperature transfer device.

Abstract: This application relates to an incubation device for serology or histology supports. It also relates to any apparatus comprising one such device, and to the use of said apparatuses and/or devices in analysis or diagnosis methods.

Abstract: Disclosed herein is a device for quantitatively supplying a liquid in a plasma sterilization system. The device includes a quantitative cylinder, a quantitative piston and a quantitative basket. The quantitative cylinder includes a quantitative inlet pipe, which is configured such that the outlet of a liquid container is inserted thereinto, and a liquid in the liquid container is vertically supplied to the quantitative cylinder, and a quantitative outlet pipe, which is configured such that the liquid is vertically drained from the quantitative cylinder. The quantitative piston is configured to rectilinearly reciprocate in the quantitative cylinder, and is provided with a quantitative transfer depression, which is formed in the leading end thereof to a predetermined depth. The quantitative basket is configured to quantitatively receive the liquid according to the rectilinear reciprocation of the quantitative piston.

Abstract: A device for applying a histological section to a slide is described. The histological section is generated by a cutting action performed by a blade of a microtome. The device comprises a positioning device having a component that is rotatably mounted to a bearing and has a receptacle for receiving and holding the slide, wherein the positioning device is designed such that the slide received in the receptacle can be rotated about an axis of rotation of the rotatably mounted component.

Abstract: A platen for contacting a liquid to a surface of a substantially flat substrate is disclosed. The platen includes a liquid application station and a stripping element at an end of the liquid application station, wherein the stripping element includes an intersecting gap and an air barrier. Also disclosed are an apparatus including the platen and a method of using the platen to contact a substrate with a liquid.

Abstract: Provided is a slide processing apparatus for processing a plurality of slides to which a bio probe is attached. The slide processing apparatus includes a reaction chamber of which side walls are sealed, and a plurality of reaction heating plates disposed in parallel in the reaction chamber at a first distance from each other. The slides are mounted adjacent to the reaction heating plates in the reaction chamber and in parallel to the reaction heating plates.

Abstract: A slide cartridge for use with a chemical analyzer includes an upper ring and a lower ring secured together but rotatable with respect to each other. The upper and lower rings define a plurality of reaction chambers between them, which receive dry analyte test slides. A gear track formed in the underside of the lower ring engages a pinion gear attached to a stepping motor of the chemical analyzer in order to rotate the slide cartridge. The slide cartridge is rotated under a sample fluid metering device, which deposits a sample fluid on the test slides through a plurality of spotter ports formed in the upper ring, and above a reflectometer, which performs a colorimetric measurement on the spotted test slides through viewing windows formed in the lower ring of the slide cartridge. A chemical analyzer with which the slide cartridge may be used includes a reflectometer, a sample fluid metering device and a stepping motor for rotating the slide cartridge.

Abstract: A holder for a plurality of biological specimen collection devices having collection absorbents extending therefrom is provided, the holder operating to organize and identify the collection devices and operating to position the collection devices for extraction of sample portions from each of the collection absorbents of the multiple collection devices while positioning a sample punch absorbent cleaning strip adjacent the collection absorbent of each device to allow cleaning of the sample punch between each use.

Abstract: A testing device for testing or analysing fluids comprises a separately produced holder (10) and a sheet-or plate-like test member (11) including analysis reagent. The holder defines an abutment surface (13) for engaging with a side surface of the test member. Projections (15) formed on the holder are positioned and shaped so as to allow insertion of the test member into the holder by moving the test member into engagement with said abutment surface while engaging with opposite edge portions thereof. The projections may, for example, be tooth-shaped and have pointed ends, and at least some of the projections may have a leading edge (16) forming a ramp sloping towards a plane defined by the abutment surface so as to facilitate insertion of the test member into the holder. A stack of such testing devices may be arranged within a cassette from which they may be fed successively into an automatic analyser. The holder of the testing device may be re-used.

Abstract: The invention relates to devices and methods for the identification of test tubes in a test tube rack using RFID technology.

Abstract: A method applying a biological specimen to an analytic plate by using an applicator device to apply a coating to the analytic plate and adhering the biological sample to the plate. The coating is substantially transparent, translucent or invisible, and is substantially flush with the surface of the analytic plate. The coating is preferably comprised of a polysiloxane, siloxane, silicone, a silane, a silicon fluid, or a combination thereof and optionally an acid.

Abstract: An arrangement for the transport and/or safekeeping of a human or animal tissue sample comprising a tablet and one or more alignment pins; each pin having a tip to pierce the cover of the tablet; the tablet designed with at least two layers that include a cover layer and a support member; and at least one alignment pin with a tip that is undercut in the direction of piercing so that it locks against the inside of the cover layer, counteracted by a lower piercing resistance of the support member in the area the piercing point. Upon piercing the cover layer, the tablet and/or the respective alignment pin limit the piercing depth of the alignment pin forming a locking event. The arrangement is designed to preserve orientation information and allow for unobscured imaging of the sample.

Abstract: The invention provides an apparatus for regulating the temperature of a chemical and/or biological sample and a method of using the same. The apparatus includes at least one temperature control module. The temperature control module includes a heater, a conductor of caloric, and a temperature sensor. The heater of the temperature control module is adapted to thermally communicate with a removable substrate, on which said chemical and/or biological sample is placed, via the conductor of caloric. The temperature sensor of the temperature control module is adapted to detect and control the temperature of the substrate via the conductor of caloric. The apparatus is designed such that the substrate is situated above said temperature control module to entirely cover said temperature control module.

Abstract: An apparatus and method of automated blood cell analysis uses technologies from other systems to create a new, robust, improved type of automated microscope, which uses electronic motors and a closed loop control system to minimize ambient factors, such as jarring and temperature changes. Pre-stained blood smear slides are first coated with a thin film of oil and are loaded into a carousel from which they can individually be analyzed. The slides are moved under a low magnification microscope; an optimal area of examination is determined; a focal plane map is calculated for that area, and the positions of white blood cell candidates are computed. The slide is then moved under a high power microscope where a refined focal plane map is computed and the individual white blood cell candidates are imaged. The cells are preclassified and the images are made available for analysis by the technician.

Abstract: An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.

Abstract: A reaction surface array diagnostic apparatus includes a substrate carrying a plurality of reaction surfaces and, a plate having a plurality of wells, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the plate and the substrate are sealingly affixed to each other in a frame. The plate is formed of a flexible material which may have an adhesive on one surface. Interlocking latch members are formed on the plate and the frame for releasably latching the plate and the frame in a position for sealing attachment to the substrate.