Means For Analyzing Liquid Or Solid Sample Patents (Class 422/68.1)
  • Patent number: 10732162
    Abstract: The present invention relates to a method for determining the disintegration time of a film-shaped pharmaceutical dosage form and a disintegration testing device for use in such a method.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: August 4, 2020
    Assignee: Hexal AG
    Inventors: Jörg Nink, Josef Pichler, Katharina Obermüller, Alexander Wotzko
  • Patent number: 10732095
    Abstract: A particle imaging device comprises a flow cell, a light source, an irradiation optical system configured to form a light sheet on the flow cell, a light collecting optical system and an imaging element. The sheet surface of the light sheet is perpendicular to the exterior side surface of the flow cell to which the light is entered from the light source. The sheet surface of the light sheet is inclined at a predetermined angle that is not perpendicular to the flow direction of the sample.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 4, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Patent number: 10717926
    Abstract: An atom, molecule, atomic layer molecular layer is adhered to a carbon nanotube surface, or the surface is doped with the atom, molecule, atomic layer, or molecular layer, to form a deep localized level so that an exciton is localized. Alternatively, an atom, molecule, inorganic or organic substance of an atomic or molecular layer, a metal, a semiconductor, or an insulator is absorbed to, deposited on, or encapsulated in the carbon tube inside surface to make permittivity of the portion undergoing the absorption, deposition, or encapsulation higher than that of a clean portion free of the absorption, deposition, or encapsulation so that binding energy of the exciton in the clean portion is high, or reduce a band gap of the portion undergoing the absorption, deposition, or encapsulation so that the exciton is confined and localized in the clean portion or the position undergoing the absorption, deposition, or encapsulation.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: July 21, 2020
    Assignee: KEIO UNIVERSITY
    Inventor: Hideyuki Maki
  • Patent number: 10712272
    Abstract: Methods and corresponding apparatus and systems for assessing cellular metabolic activity are disclosed. In one aspect, a cell can be illuminated with optical radiation in order to cause multi-photon excitation of at least one endogenous metabolic cofactor in that cell and cause the excited metabolic cofactor to emit fluorescent radiation. A detector can be used to detect the fluorescent radiation emitted by the excited endogenous metabolic cofactor. A computer processor can analyze the fluorescent radiation to derive the following parameters: (1) using a computer processor to analyze the intensity of the fluorescent radiation, (2) a fluorescence lifetime of at least one of the excited metabolic cofactor, (3) a parameter indicative of mitochondrial clustering in the cell. These parameters can be used to assess at least one metabolic process of the cell.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: July 14, 2020
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: Irene Georgakoudi, Dimitra Pouli, Kyle P. Quinn, Zhiyi Liu
  • Patent number: 10712284
    Abstract: The present invention relates to a method for grafting, in a covalent manner, a coloured indicator having at least one aromatic primary amine function onto the surface of a solid substrate, including the steps that consist of: (a) preparing, from the coloured indicator having at least one aromatic primary amine function, the corresponding diazonium salt; (b) placing the solid substrate in contact with a solution containing the diazonium salt prepared in step (a) and subjecting the solution to non-electrochemical conditions for an optimal grafting time whereby organic chains in which the units are derivatives of the diazonium salt are grafted, in a covalent manner, onto the surface of the solid substrate; (c) washing the solid substrate thus grafted; (d) repeating steps (b) and (c) or possibly steps (a) to (c) at least once. The present invention also relates to a kit for implementing such a method.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: July 14, 2020
    Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Denis Doizi, Guy Deniau, Mathias Fages
  • Patent number: 10702868
    Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: July 7, 2020
    Assignee: National Research Council of Canada
    Inventors: Teodor Veres, Daniel Brassard, Liviu Clime, Francois Normandin
  • Patent number: 10692388
    Abstract: Provided is an engine health management system and method for determining health of an engine of an aircraft, that includes a data source interface which transmits data from internal and external data sources, a control module that includes a processor and a memory and receives data via the data source interface, creates evaluation methods for evaluating the data received to determine suitable data and storing the suitable data within the memory, and creates a controlled historical airport information repository to process historical data via the processor and generate airport information reports based on the historical data. The system also includes a central computing system communicatively coupled with the control module and the data source interface, which performs data enhancement techniques including linking environmental counts and accumulations with engine data.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 23, 2020
    Assignee: General Electric Company
    Inventors: Andrew Scott Kessie, Michael H. Fisher, Daniel Maggard, Byron Andrew Pritchard
  • Patent number: 10684299
    Abstract: This disclosure concerns a method and a system for quality evaluation of a handheld analytical device, wherein the device is operable by a human user in a sequence of handling steps to test an analyte in a sample fluid applied on a test element, the method comprising the steps of (a) programming a handling cycle for a robot having at least one robot arm in order to mimic the sequence of handling steps, (b) operating the device in at least one handling cycle by means of the robot, (c) monitoring the operation in step (b) by a control unit to evaluate at least one parameter influencing the quality of the device.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: June 16, 2020
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Wolfgang Schwoebel
  • Patent number: 10675629
    Abstract: A point of use analyzer includes pump, valve, port, and storage channel. The storage channel may hold multiple assay packets composed of reagent aliquots separated by bounding slugs. The storage channel may define an elongated lumen having two ends with each of the ends coupled to the valve. A sampling device for use with the analyzer engages the port and may include a recurrent coaxial tube having a separation medium. A method of using the analyzer with the sampling device includes steps of pumping a fluid to displace a sample into the separation medium and out through the opposed connection.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 9, 2020
    Inventor: Michael L. Bell
  • Patent number: 10677780
    Abstract: Compositions, kits, and devices that include calibration and/or quality control reagent(s) for monitoring the performance of blood gas, electrolyte, and/or metabolite instrumentation are disclosed. Different oxygen levels in the calibration and/or quality control reagent(s) can be generated using an oxygen scavenger. Methods of accurately measuring the oxygen levels so generated using a by-product of the oxygen scavenger are also disclosed.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: June 9, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Bong Oh
  • Patent number: 10678914
    Abstract: This disclosure relates to detection of viruses. In one implementation, a virus detection method performed by a terminal device is disclosed. The method may include obtaining a full characteristic features of a first file, the first file being a sample file collected by a client application of the terminal device, and the full characteristic features of the first file being used to uniquely determine all components of the first file, obtaining a first binary hash sequence based on the full characteristic features of the first file and by using a preset hash algorithm, calculating similarity parameters between the first binary hash sequence and reference binary hash sequences in an antivirus database, each binary hash sequence in the antivirus database corresponding to one type of virus-infected file, and determining the first file as a virus-infected file when at least one of the similarity parameters is less than a preset similarity threshold.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: June 9, 2020
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventor: Jingwei Lei
  • Patent number: 10670596
    Abstract: It is an object of the present invention to provide improved methods and compositions for manufacture and use of lateral flow test devices. In particular, the present invention provides a molding method which provides one or more features in the housing base configured to retain the test strip within the base. These features are provided as undercuts in the housing base. The test strip is configured as a bibulous lateral flow material disposed on a substantially non-compressible base layer, and the base layer is positioned within the undercut in order to retain the test strip in the housing base. Optionally, one or more features in the housing base which create the undercut are configured to engage the bibulous lateral flow material by compression and/or friction, thereby increasing the ability of the base to maintaining the test strip in its proper position within the device.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: June 2, 2020
    Assignee: Astute Medical, Inc.
    Inventors: Joseph Anderberg, John Van Bosch
  • Patent number: 10663420
    Abstract: The present invention is directed to a sensor having continuous and discontinuous regions of conductive metallic nanoparticles capped with an organic coating which enables the detection of volatile organic compounds and/or water vapor. Continuous regions may exhibit a positive response upon exposure to volatile organic compounds and to water vapor, while discontinuous regions exhibit a negative response upon exposure to water vapor larger than the positive response of the continuous region.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: May 26, 2020
    Assignee: Technion R&D Foundation Ltd.
    Inventors: Hossam Haick, Meital Segev-Bar, Gregory Shuster, Sagi Gliksman
  • Patent number: 10656059
    Abstract: A method for qualitative and quantitative multiplexing of drug analytes from dried blood samples includes the steps of mixing an Internal Standard solution with a first diluent in a vessel, adding the dried blood sample to the vessel, sonicating the vessel containing the Internal Standard solution, the first diluent and the dried blood sample, removing the dried blood sample from the vessel so that a final sample can be attained, and analyzing at least a portion of the final sample using one of LC-MS and LC-MS/MS to simultaneously determine the presence or absence of a plurality of different analytes in the dried blood sample. The Internal Standard solution can include at least 8, 15, 25 or 50 Internal Standards. The dried blood sample is generated using less than 50 ?L, 20 ?L or 10 ?L of blood. The step of analyzing includes simultaneously determining the presence or absence of at least 15, 60, 90 or 130 different analytes.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: May 19, 2020
    Assignee: ALCALA PHARMACEUTICAL, INC.
    Inventors: David J. Smith, Matthew D. Rifat, Christian Tagwerker, Irfan Baig, Ranulu Samanthi de Zoysa, Eric J. Brunson
  • Patent number: 10641698
    Abstract: The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (CBC) testing. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing blood cells in a sample.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 5, 2020
    Assignee: CYTOCHIP INC.
    Inventors: Wendian Shi, Yuzhe Ding
  • Patent number: 10631965
    Abstract: A whitening smart pen apparatus (10) for automatically dispensing a teeth whitening substance onto one or more teeth of a user comprises a fluid reservoir (16), a nozzle (18) having an output port (26), a fluid dispenser (20), a sensor (22) and a controller (24). The fluid dispenser dispenses the teeth whitening substance from the fluid reservoir to the nozzle and is output via the output port. The sensor, positioned in an advance dispensing direction of the nozzle, senses a target surface that comprises either (i) a tooth surface (12) or (ii) other surface (14). The controller (24) is configured for (i) controlling a gating of the fluid dispenser (20) to dispense the teeth whitening substance from the fluid reservoir (16) in response to the sensor (22) detecting the tooth surface (12), and (ii) stopping or disabling the gating of the fluid dispenser to stop or disable a dispensing of the teeth whitening substance from the fluid reservoir in response to the sensor (22) detecting the other surface (14).
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: April 28, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Vincent Jeanne, Meng Peng, Jianxun Feng, Wan-Tzu Chen, Evan Dak Wah Dengler, Sungsoo Lee
  • Patent number: 10620199
    Abstract: A sensing sensor includes a wiring board, a piezoelectric resonator, and a gel-like protective agent. The piezoelectric resonator has one surface side on which an adsorbing film is formed. The adsorbing film is constituted of biomolecules. The protective agent is disposed so as to cover a surface of the adsorbing film. The protective agent is configured to suppress an inactivation of the biomolecules. The channel forming member is disposed so as to cover a region of the one surface side of the wiring board including the piezoelectric resonator. The channel forming member includes an injection port of the sample solution. The flow passage is disposed between the wiring board and the channel forming member. The flow passage is configured to allow the sample solution supplied to the injection port to flow from one end side to another end side on the one surface side of the piezoelectric resonator.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 14, 2020
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventor: Wakako Shinobu
  • Patent number: 10619151
    Abstract: A method for extracting a nucleic acid from a sample liquid comprises providing a heating element and providing an extraction nucleic acid that is bound to the heating element and/or providing the extraction nucleic acid such that the extraction nucleic acid binds to the heating element. The extraction nucleic acid is at least partly complementary to the nucleic acid. The method further comprises bringing the heating element into contact with the sample liquid such that the nucleic acid at least partly binds to the extraction nucleic acid, and separating the heating element from the sample liquid such that the nucleic acid bound to the extraction nucleic acid remains at the heating element. Additionally, the method comprises bringing the heating element into contact with a reaction solution, and heating the heating element to at least a denaturing temperature of the nucleic acid.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: April 14, 2020
    Assignee: GNA BIOSOLUTIONS GmbH
    Inventors: Joachim Stehr, Lars Ullerich, Federico Bürsgens, Domenik Zistl, Simon Schmidbauer, Daniel Grodd, Cecilia Rebuffo-Scheer, Lidiya Osinkina
  • Patent number: 10613082
    Abstract: Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: April 7, 2020
    Assignee: i-calQ, LLC
    Inventor: Joel R. L. Ehrenkranz
  • Patent number: 10615017
    Abstract: A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for CIDs in respective stages. If an MS1 spectrum on which CID is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage CID exists on the MS1 spectrum, based on the list held in the memory unit. If the ion exists, an MS2 analysis in which the ion is set as a precursor ion is immediately executed. Subsequently, the precursor ion selector determines whether or not an ion registered as a precursor ion for the second-stage CID in association with the precursor ion for the first-stage CID exists on an MS2 spectrum. If the ion exists, an MS3 analysis in which the ion is set as a precursor ion is immediately executed, so that an MS3 spectrum is acquired.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: April 7, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Tairo Ogura
  • Patent number: 10603667
    Abstract: Provided are a device and a cleaning mechanism for a reaction container in the device that are characterized by being provided with: a reaction disk for holding a reaction container; a sample dispensing mechanism for dispensing a sample to the reaction container; a reagent dispensing mechanism for dispensing a reagent to the reaction container; an optical system comprising a light source for applying light to a mixture of the sample and the reagent dispensed to the reaction container, and a detector for detecting the light applied from the light source; and a cleaning mechanism for cleaning the reaction container, wherein the cleaning mechanism is provided with a cleaning liquid supply nozzle for supplying a cleaning liquid to the reaction container after an analysis, a cleaning liquid suction nozzle for suctioning the supplied cleaning liquid, and a cleaning tip provided on the lower end of the cleaning liquid suction nozzle, and the side surface of the cleaning tip is formed such that the width of the clean
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kei Shioya, Masahiko Iijima
  • Patent number: 10604755
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a Lipid transport and metabolism gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a Lipid transport and metabolism genes.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 31, 2020
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman, Carlos Coito
  • Patent number: 10605815
    Abstract: The present invention provides a full-automatic feces analyzer, comprising an automatic controller; at least one sample box for containing a feces sample; a sample box support for placing the sample box; a dilution and stirring unit for adding diluent into the feces sample in the sample box and performing stirring to obtain feces sample liquid; a physical detection unit for performing a physical detection on the feces sample liquid; at least one chemical detection unit for performing a chemical detection on the feces sample liquid, each chemical detection unit comprising a driving roller and a driven roller, a reagent strip roll being wound on the driven roller, an end portion of the reagent strip roll being fixed on the driving roller, and the reagent strip roll comprising a plurality of reagent strips which are abreast distributed and sequentially connected; and a sample sucking and adding unit for sucking the feces sample liquid and delivering the feces sample liquid to the physical detection unit and the
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 31, 2020
    Assignee: SUZHOU HALO BIO-TECH CO., LTD.
    Inventor: Xianglong Li
  • Patent number: 10605804
    Abstract: Disclosed is an analysis method including: moving a complex, by means of a magnet unit, in a flow path of a specimen cartridge which includes the flow path and a detection vessel, the complex containing a test substance formed on magnetic particles and a labeled substance binding to the test substance; taking an image of the magnetic particles in the specimen cartridge; and measuring a label of the labeled substance contained in the complex in the detection vessel.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kosuke Jitsuhara, Jianyin Lu
  • Patent number: 10598675
    Abstract: The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: March 24, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball
  • Patent number: 10589997
    Abstract: Discrete, individualized carbon nanotubes having targeted, or selective, oxidation levels and/or content on the interior and exterior of the tube walls are claimed. Such carbon nanotubes can have little to no inner tube surface oxidation, or differing amounts and/or types of oxidation between the tubes' inner and outer surfaces. These new discrete carbon nanotubes are useful in plasticizers, which can then be used as an additive in compounding and formulation of elastomeric, thermoplastic and thermoset composite for improvement of mechanical, electrical and thermal properties.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 17, 2020
    Assignee: Molecular Rebar Design, LLC
    Inventors: Kurt W. Swogger, Clive P. Bosnyak, Nancy Henderson, Malcolm Finlayson, Bryce Sturtevant, Steve Hoenig
  • Patent number: 10589277
    Abstract: An apparatus and associated method are provided for sensing an analyte, such as acetone, in breath. The apparatus includes a sorbent material that extracts the analyte from a dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: March 17, 2020
    Assignee: INVOY HOLDINGS, LLC
    Inventors: Lubna M. Ahmad, Rhett L. Martineau
  • Patent number: 10582361
    Abstract: Some embodiments of the present invention include pairing two wireless devices by placing at least one of two devices in a pairing mode; performing at least one pairing motion event with at least one of the wireless devices to satisfy at least one pairing condition; detecting satisfaction of the at least one pairing condition; and pairing the two wireless devices in response to detecting satisfaction of the at least one pairing condition. Numerous other aspects are provided.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: March 3, 2020
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Qiang Fu, Alexander Markovic, Joseph R. Anstett, Jr., Vladislav Milenkovic
  • Patent number: 10557837
    Abstract: Nonuse-indication information can be set for each peak on a mass spectrum collected in a compound database, as attribute information, the nonuse-indication information allowing the selection of whether to be used in a database search. For example, nonuse-indication information is set in advance to a noise peak mixed in actual measurement, an impurity-originated peak, and the like. In identifying a compound, when nonuse-indication information is read from the database for a database search together with a mass spectrum, an unnecessary information deleting section transmits a mass spectrum from which a peak set with the nonuse-indication information is deleted, to a compound candidate extracting section and a scoring section. Therefore, a peak set with the nonuse-indication information is ignored in, for example, calculating the score of a compound candidate, which allows a score with a high accuracy to be calculated, resulting in an improved identification accuracy.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: February 11, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Tetsuya Kageyama, Yoshikatsu Umemura
  • Patent number: 10549018
    Abstract: The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 4, 2020
    Assignee: LIFECELL CORPORATION
    Inventors: Sangwook Park, Jerome Connor, Aaron Barere
  • Patent number: 10520404
    Abstract: A biomolecule extraction device and method for use thereof are disclosed. The biomolecule extraction device has an insertion part, a body part and at least on discharge port. The insertion port is insertable in a body part, and is configured to fix a sample of collected biomass containing biomolecules. The body part is configured to receive a lyses buffer and contact the surface of the fixed biomass with the lyses buffer to extract the biomolecules from the biomass when the insertion part is inserted in the body part. The at least one discharge part is disposed in the insertion part or the body part for discharging biomass lysate containing the extracted biomolecules.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: December 31, 2019
    Assignee: L'OREAL
    Inventors: Woo-Young Sim, Yu-Rae Kim, Jae-Jeong Kim, Eun-Ji Lee
  • Patent number: 10511151
    Abstract: A method for fabricating a nanostructure comprises the steps of growing a first nanowire on a substrate, forming a dielectric layer on the substrate, the dielectric layer surrounding the first nanowire, wherein a thickness of the dielectric layer is smaller than a length of the first nanowire, and removing the first nanowire from the dielectric layer, thereby exposing an aperture in the dielectric layer.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: December 17, 2019
    Assignee: Technische Universitaet Muenchen
    Inventors: Gregor Koblmueller, Benedikt Mayer, Jonathan Finley, Gerhard Abstreiter
  • Patent number: 10487301
    Abstract: Disclosed are a reaction tube for nucleic acid amplification capable of controlling a liquid circulation path, a reaction apparatus for nucleic acid amplification comprising the reaction tube, and a method for amplifying nucleic acid comprising a step of using the reaction tube. Also disclosed are a kit comprising the reaction tube, and use of the reaction tube in preparation of a kit.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: November 26, 2019
    Assignees: XIAMEN UNIVERSITY, XIAMEN INNODX BIOTECH CO., LTD.
    Inventors: Shengxiang Ge, Shiyin Zhang, Feihai Xu, Jin Wang, Jinjie Li, Jun Zhang, Ningshao Xia
  • Patent number: 10457744
    Abstract: The invention provides TIMP2 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays rely on the selection and use of antibodies and antibody pairs that exhibit improved assay performance when used in complex clinical specimens such as biological fluids, and particularly when used in rapid assay formats such as lateral flow test devices.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 29, 2019
    Assignee: Astute Medical, Inc.
    Inventors: Ravi A. Vijayendran, Srivatsa Venkatasubbarao
  • Patent number: 10458891
    Abstract: The invention refers to an in vitro method and apparatus for analyzing the behavior of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: October 29, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hanns-Christian Mahler, Dhananjay Jagdish Jere, Sulabh Patel
  • Patent number: 10453321
    Abstract: A pre-smoke detector and system for use in early detection of developing fires whereby vapors of marker chemicals generated during the melting and/or smoldering of common household materials are detected before detection by conventional smoke detectors. Vapors resulting from heating and resultant vaporization of substances are detected as well as vapors resulting from their breakdown, decomposition, or pyrolysis during the pre-combustion stage. Conventional smoke detectors focus on particle detection and are most effective after a developing fire has produced smoke. To minimize false alarms caused by common household odors, the pre-smoke detectors focus on detecting medium temperature pyrolysis products using sensor coatings that can be consistent with a 10-year operational lifetime and multiple orthogonal detection processes.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: October 22, 2019
    Assignee: Nevada Nanotech Systems Inc.
    Inventors: Jesse D. Adams, Ralph G. Whitten
  • Patent number: 10450594
    Abstract: A photosynthetic device includes a main body defining a microfluid chamber for causing photosynthesis therein, and a light source, wherein the microfluid chamber is constituted by at least one communication room, a plurality of micro channels respectively and spatially communicated with the communication room, at least one micro injection duct spatially communicated with the communication room, and a plurality of filter plugs spatially connected to the micro channels respectively and the micro injection duct at free ends thereof in order to filter fluid backflow in the micro channels and the micro injection duct. The light source radiates ceaselessly one of the communication room, the plurality of micro channels and the micro injection duct. The photosynthesis is resulted once chloroplasts and normal saline solution are injected into one of the communication room, the plurality of micro channels and the micro injection duct.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: October 22, 2019
    Inventor: Po-Kang Lin
  • Patent number: 10448875
    Abstract: A substance measurement device includes: a container portion configured to receive a substance; a sensing device configured to measure a property of the substance related to at least one of a flow rate of the substance into the container portion, a level of the substance within the container portion, and a volume of the substance within the container portion; and at least one shield positioned within the container portion and configured to provide at least one of: a mechanical buffer between the substance entering the container portion and the sensing device; and an electrical shield between the substance entering the container portion and the sensing device.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 22, 2019
    Assignees: Stream Dx, Inc, University of Utah Research Foundation
    Inventors: Brian D. Holt, Scott B. McClellan, Alvin Y. Le, Kent James Ogden
  • Patent number: 10446377
    Abstract: The invention relates to a gas inlet system for providing gas into an analytical apparatus, comprising at least a first and a second flow restriction that are arranged on a gas inlet line, a gas flow control line connected to the gas inlet line, a gas flow controller on the gas control line, and valves for controlling gas flow in the gas inlet line and the gas control line. Also provided is a method of controlling gas flow into an analytical apparatus.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 15, 2019
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Hans-Juergen Schlueter
  • Patent number: 10422785
    Abstract: A tissue identification method including a preparation step and a detection step is provided. The preparation step includes preparing a biosensor which includes a transistor and a response electrode. The response electrode is spaced apart from the transistor relative to a gate terminal of the transistor. The detection step includes disposing a biological tissue sample to be identified on the response electrode, applying a pulse voltage that has a tunable pulse width and a tunable pulse height to the response electrode, resulting in a voltage difference between the response electrode and the gate terminal of the transistor, and measuring and calculating a detection current which is generated from the transistor in the pulse width, so as to obtain a first sensing indicator. In addition, a biosensor for tissue identification is also provided.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: September 24, 2019
    Assignee: National Tsing Hua University
    Inventors: Yu-Lin Wang, Indu Sarangadharan
  • Patent number: 10415009
    Abstract: A cell culture device comprises a cell culture membrane and a substrate fixed to the cell culture membrane. The cell culture membrane is made from a thermosetting resin and has a plurality of pores that are open to at least one surface including a surface on a side that is in contact with the substrate. The substrate is made from a thermoplastic resin. In a contact region between the cell culture membrane and the substrate, part of the substrate is extended to form bulges in the pores of the cell culture membrane that are open in the contact region. This configuration suppresses reduction of the strength of the cell culture membrane and reduction of the flatness of the cell culture membrane (membrane accuracy) in the cell culture device in which the cell culture membrane and the substrate are fixed to each other.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: September 17, 2019
    Assignees: TOYODA GOSEI CO., LTD., NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIV.
    Inventors: Seitaro Taki, Hiroyuki Nakagawa, Atsuki Yoshimura, Masaru Tanaka
  • Patent number: 10408810
    Abstract: A soil testing method determines available nutrient levels and effective and economical fertilizer/treatment, based on what nutrients in the soil will actually reach the root of a growing plant. A soil is tested to determine initial nutrient(s) available to a plant root if it were growing in that soil when no nutrients have been added, followed by comparing/correlating the initial available nutrient to nutrient requirements for desired plant growth during one or more periods of time and/or to a yield outcome desired. Various doses of fertilizer(s) or treatment(s) are then added to portions of the soil, and those dosed portions are then tested for available nutrient levels, to determine the effect of the fertilizer(s)/treatment(s) on the nutrients that would be available in that particular soil to a plant root if that soil were fertilized with the various doses.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 10, 2019
    Assignee: UNIBEST INTERNATIONAL, LLC
    Inventors: Mark James Riess, Brennan Allan Ingram, Kristopher James Borgman, Robert Gabriel Melanson, Jennifer Ann Chapman, Ivan Rozumny
  • Patent number: 10371670
    Abstract: A hybrid device comprising Metal Oxide Sensors in a Gas Chromatography column is described, whereby the readings from the MOS devices will vary along the column in reaction to the sample reflecting the differential delays imposed on the components of the sample depending on the elutive effect of the adsorbent lining the column for the respective component. By this means, a family of readings is obtained, any one of which may be easier to interpret for a particular sample, and which may be compared amongst themselves providing an additional measurement dimension. The behavior of later sections of column or sensors may be modified dynamically during a measurement cycle depending on the readings obtained at the earlier stages.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: August 6, 2019
    Assignee: ALPHA M.O.S.
    Inventors: François Loubet, Sébastien Pelletier, Sandrine Isz, Jean-Christophe Mifsud
  • Patent number: 10345233
    Abstract: An optical measuring device for measuring a measurement region, the optical device comprising a photonic chip with an interferometer defined on said chip, said interferometer comprising first and second waveguides on said photonic chip and an interference region, wherein the first and second waveguides carry signals from the interference region to the sample region and back to the interference region, the device further comprising a phase adjusting unit configured to vary a phase difference between the signals in the first and second waveguides reflected by the measurement region.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: July 9, 2019
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Anthony John Bennett, David Julian Peter Ellis, Andrew James Shields, Thomas David Meany
  • Patent number: 10343170
    Abstract: According to one aspect of the invention, an apparatus is provided for sensing an analyte, such as acetone, in breath. The apparatus includes a conditioning device that dehumidifies a breath sample, a sorbent material that extracts the analyte from the dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 9, 2019
    Assignee: Invoy Holdings, LLC
    Inventors: Lubna M. Ahmad, Rhett L. Martineau
  • Patent number: 10345295
    Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: July 9, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Saurabh Mehta, David Erickson, Seoho Lee
  • Patent number: 10347835
    Abstract: A layer structure, a manufacturing method thereof, a display substrate, a backlight and a display device are provided. The manufacturing method includes forming a layer solution on a substrate (21); solidifying the layer solution by lowering the temperature of the layer solution; and forming the layer structure by removing a solvent in the solidified layer solution via a sublimation process.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 9, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Wei Xu, Jikai Yao, Kang Guo
  • Patent number: 10337939
    Abstract: A waterproof member includes a laminated body including a second silicon layer and a second silicon oxide layer, and a through hole that is provided in the laminated body, prevents passing of liquid, and allows passing of gas, the through hole includes a first through hole that passes through the second silicon layer, and a second through hole passing through the second silicon oxide layer and communicating with the first through hole, and a width of the second through hole is smaller than a width of the first through hole.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 2, 2019
    Assignee: Seiko Epson Corporation
    Inventor: Nobuyuki Tanaka
  • Patent number: 10288577
    Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: May 14, 2019
    Assignee: AgaMatrix, Inc.
    Inventors: Sridhar Iyengar, Ian Harding, Charles Boiteau, Colin Butters
  • Patent number: 10287180
    Abstract: A water monitoring device monitors and maintains swimming pool chemistry. The device mixes reagents with water in flowcells. The water chemistry is detected by measuring the light transmitted through the flowcells. The water monitoring device can communicate with computers, servers and mobile computing devices which can store and display the water chemistry information. The reagents can be stored in a replaceable reagent cartridge which can provide reagents for water testing and can be replaced when the reagents need to be replenished.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 14, 2019
    Assignee: SUTRO CONNECT INC.
    Inventors: Ravi Kurani, Daniel Proterra, Alexandr Valeyev