Means For Analyzing Liquid Or Solid Sample Patents (Class 422/68.1)
  • Patent number: 10345233
    Abstract: An optical measuring device for measuring a measurement region, the optical device comprising a photonic chip with an interferometer defined on said chip, said interferometer comprising first and second waveguides on said photonic chip and an interference region, wherein the first and second waveguides carry signals from the interference region to the sample region and back to the interference region, the device further comprising a phase adjusting unit configured to vary a phase difference between the signals in the first and second waveguides reflected by the measurement region.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: July 9, 2019
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Anthony John Bennett, David Julian Peter Ellis, Andrew James Shields, Thomas David Meany
  • Patent number: 10345295
    Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: July 9, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Saurabh Mehta, David Erickson, Seoho Lee
  • Patent number: 10343170
    Abstract: According to one aspect of the invention, an apparatus is provided for sensing an analyte, such as acetone, in breath. The apparatus includes a conditioning device that dehumidifies a breath sample, a sorbent material that extracts the analyte from the dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 9, 2019
    Assignee: Invoy Holdings, LLC
    Inventors: Lubna M. Ahmad, Rhett L. Martineau
  • Patent number: 10347835
    Abstract: A layer structure, a manufacturing method thereof, a display substrate, a backlight and a display device are provided. The manufacturing method includes forming a layer solution on a substrate (21); solidifying the layer solution by lowering the temperature of the layer solution; and forming the layer structure by removing a solvent in the solidified layer solution via a sublimation process.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 9, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Wei Xu, Jikai Yao, Kang Guo
  • Patent number: 10337939
    Abstract: A waterproof member includes a laminated body including a second silicon layer and a second silicon oxide layer, and a through hole that is provided in the laminated body, prevents passing of liquid, and allows passing of gas, the through hole includes a first through hole that passes through the second silicon layer, and a second through hole passing through the second silicon oxide layer and communicating with the first through hole, and a width of the second through hole is smaller than a width of the first through hole.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 2, 2019
    Assignee: Seiko Epson Corporation
    Inventor: Nobuyuki Tanaka
  • Patent number: 10287180
    Abstract: A water monitoring device monitors and maintains swimming pool chemistry. The device mixes reagents with water in flowcells. The water chemistry is detected by measuring the light transmitted through the flowcells. The water monitoring device can communicate with computers, servers and mobile computing devices which can store and display the water chemistry information. The reagents can be stored in a replaceable reagent cartridge which can provide reagents for water testing and can be replaced when the reagents need to be replenished.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 14, 2019
    Assignee: SUTRO CONNECT INC.
    Inventors: Ravi Kurani, Daniel Proterra, Alexandr Valeyev
  • Patent number: 10288577
    Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: May 14, 2019
    Assignee: AgaMatrix, Inc.
    Inventors: Sridhar Iyengar, Ian Harding, Charles Boiteau, Colin Butters
  • Patent number: 10279540
    Abstract: A two-dimensional nano-sheet that is foldable in response to a surrounding pH value includes a polyethyleneimine (PEI) chain taking a two-dimensional form; and a plurality of domains made of gold, attached to the PEI chain, the plurality of domains of gold forming a percolating gold film on the PEI chain.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: May 7, 2019
    Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOO
    Inventors: Jeong-Hwan Kim, Murtaza Bohra, Vidya Dhar Singh, Antony Douglas Galea, Panagiotis Grammatikopoulos, Mukhles Ibrahim Sowwan
  • Patent number: 10272429
    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: April 30, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Terry Gaige, Andrew Zayac, Paul Sydlowski, Philip Lee
  • Patent number: 10267742
    Abstract: The present invention provides for the analysis of colorimetric or fluorometric assays by way of capturing an image of the assay on the camera (32) built into the mobile phone (30). A disposable tool (20) is provided to enable the assay to be positioned an appropriate distance from the phone camera (30). A software application on the phone (30) can then analyze the captured image to determinate a qualitative or quantitative outcome of the assay. In many examples, the test will require no modification of the phone hardware and is thus a convenient and cheap technique for analyzing an assay. In other embodiments, other disposable items such filter(s) (41, 42) and/or additional light source(s) (LED 22) may be provided.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: April 23, 2019
    Assignee: Lumophore Limited
    Inventor: Farid Khan
  • Patent number: 10267734
    Abstract: Provided are inexpensive devices and methods for obtaining emission or scattering spectra of multiple particles simultaneously and for characterizing the particles based on their emission or scattering spectra. The disclosed devices and methods are useful for analyzing multiple particles to determine one or more characteristics of the particles, such as size, type, elastic scattering, fluorescence and/or Raman characteristics, for distinguishing between biological and non-biological particles, and for biomedical assaying applications. Laboratory or research grade spectroscopic devices are described. Smartphone-based spectroscopic devices are also described, where various components of a smartphone are used for data collection and analysis purposes.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: April 23, 2019
    Assignee: Colorado Seminary Which Owns and Operates the University of Denver
    Inventors: Donald Ray Huffman, John Alexander Huffman
  • Patent number: 10260336
    Abstract: Methods for determining the hardness and/or ductility of a material by compression of the material are provided as a first aspect of the invention. Typically, compression is performed on multiple sides of a geologic material sample in a contemporaneous manner. Devices and systems for performing such methods also are provided. These methods, devices, and systems can be combined with additional methods, devices, and systems of the invention that provide for the analysis of compounds contained in such samples, which can indicate the presence of valuable materials, such as petroleum-associated hydrocarbons. Alternatively, these additional methods, devices, and systems can also stand independently of the methods, devices, and systems for analyzing ductility and/or hardness of materials.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: April 16, 2019
    Inventor: Michael Smith
  • Patent number: 10234467
    Abstract: Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a pH probe (66) which is connectable to a supply of carbon dioxide (32, 34), as well as to a supply of helium (40), the supplies being controlled by a control unit (50). The control unit (50) monitors changes in pH of the solvent medium (18) and, as appropriate, feeds pH increasing and/or pH reducing gas from the supplies (32, 34, 40) into the chamber (12). The control unit (50) is able to maintain a uniform pH during testing or to provide a dynamically adjustable pH during testing, for example to three or more different pH levels in order to test the performance of a drug carrier at different levels of acidity or alkalinity for example, mimicking the conditions of the gastrointestinal tract.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: March 19, 2019
    Assignee: UCL Business PLC
    Inventors: Hamid Ali Merchant, John Andrew Frost, Abdul Waseh Basit
  • Patent number: 10228367
    Abstract: A segmented multi-use automated assay cartridge for conducting a fluid assay includes a plurality of microfluidic assay circuits having the fluid flow channels configured to perform an assay on a sample, each circuit is configured to receive fluids for performing the assay (e.g., sample, buffer, detection analyte, dye, etc.) and each circuit is also configured to dispense waste fluid of the assay to a corresponding fluidic waste channel. A waste tower is configured to received waste fluid from the fluidic waste channel and to dispense the waste fluid to a common waste reservoir, whereby the assay waste fluid from each circuit comingles in the common waste reservoir and does not comingle with waste fluid from other circuits in the device in the fluidic waste channel, which allows multiple different assays to be run by the cartridge at different times.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: March 12, 2019
    Assignee: ProteinSimple
    Inventors: Charles Stanwood, Noel Daigneault, Jeffrey Branciforte
  • Patent number: 10214757
    Abstract: A photosynthetic device includes a main body defining a microfluid chamber for causing photosynthesis therein, and a light source, wherein the microfluid chamber is constituted by at least one communication room, a plurality of micro channels respectively and spatially communicated with the communication room, at least one micro injection duct spatially communicated with the communication room, and a plurality of filter plugs spatially connected to the micro channels respectively and the micro injection duct at free ends thereof in order to filter fluid backflow in the micro channels and the micro injection duct. The light source radiates ceaselessly one of the communication room, the plurality of micro channels and the micro injection duct. The photosynthesis is resulted once chloroplasts and normal saline solution are injected into one of the communication room, the plurality of micro channels and the micro injection duct.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: February 26, 2019
    Inventor: Po-Kang Lin
  • Patent number: 10216899
    Abstract: In some examples, a method may include obtaining, from a DNA sequence, a DNA bin that includes a number of consecutive DNA elements equal to a bin length parameter and constructing sentences from the DNA bin to form a constructed sentence set that includes a number of sentences equal to a size parameter. Each sentence of the constructed sentence set may be constructed by partitioning the DNA bin into words, each word comprising a number of DNA elements equal to the size parameter. Each sentence of the constructed sentence set may include overlapping DNA elements with other sentences of the constructed sentence set and may start with a different DNA element of the DNA bin. The method may further include using the constructed sentence set to train a classifier and determining a DNA classification for an unclassified DNA subsequence through the classifier trained using the constructed sentence set.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: February 26, 2019
    Assignee: HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP
    Inventors: Mehran Kafai, Kari Lam
  • Patent number: 10208332
    Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: February 19, 2019
    Inventors: David Eberhart, William D. Nielsen, Helen Franklin, Stevan B. Jovanovich, Dennis Lehto, Kaiwan Chear, James Klevenberg, Chungsoo Charles Park, Corey Smith, Philip Justus Wunderle, David King
  • Patent number: 10203346
    Abstract: Provided is an automatic analysis device capable of reducing a reagent cost. In the present invention, in each mixed reagent preparation cycle, an amount of mixed reagent for N analyses is mixed and prepared, and an amount of mixed reagent for one analysis is dispensed from the amount of mixed reagent for N analyses and used to analyze one sample. Minimum (Nmin) and maximum (Nmax) values for N are determined for a control unit beforehand, and if the analysis of J samples is requested, the control unit sets the value of N at the time of a mixed reagent preparation cycle within a range from Nmin to Nmax so as to minimize the remaining mixed reagent.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: February 12, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Daisuke Morishima, Kohshi Maeda
  • Patent number: 10188327
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 29, 2019
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
  • Patent number: 10191074
    Abstract: An automatic analyzing apparatus capable of eliminating static electricity charged in a specimen container at a specimen dispensing position provided. The automatic analyzing apparatus includes a dispensing mechanism having a probe that aspirates a liquid and an arm that holds the probe, and a static eliminator having a generation source of neutralizing ions and a neutralizing ion blowing mechanism for blowing the neutralizing ions generated in the generation source to a target, which are provided in the dispensing mechanism.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: January 29, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Kenichi Nishigaki
  • Patent number: 10168308
    Abstract: Provided is an analysis device capable of obtaining sufficient sensitivity to a gas phase component, which is the analysis target, by a mass spectrometer even when a reactive gas is used as a carrier gas in evolved gas analysis. An analysis device 1 includes a heating device 3, a first carrier gas introduction device 4, a connecting conduit 5, a capillary tube 6, an oven 2, a mass spectrometer 7, and a second carrier gas introduction device 8. The second carrier gas introduction device 8 is configured to introduce helium, hydrogen and/or nitrogen into the connecting conduit 5.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 1, 2019
    Assignee: FRONTIER LABORATORIES LTD.
    Inventors: Akihiko Hosaka, Atsushi Watanabe, Chuichi Watanabe
  • Patent number: 10156573
    Abstract: The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose having two boronic acid moieties, a probe for sensing oxygen comprising modified porphyrin, an intra-reference probe that is rhodamine-based, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 18, 2018
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventors: Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
  • Patent number: 10150680
    Abstract: A water monitoring device monitors and maintains swimming pool chemistry. The device includes sensors that detect water chemistry. The water monitoring device can communicate with computers and servers. This system can be used to determine if corrections to the water chemistry are required to maintain water sanitation. The device can monitor: pH, air temperature, water temperature, free chlorine levels, oxidation reduction potential, alkalinity, oxygen demand, water movement and velocity, and electrical conductivity.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: December 11, 2018
    Assignee: SUTRO CONNECT INC.
    Inventors: Ravi Kurani, Andrew Redfern, Alexandr Valeyev, Delia Gratta
  • Patent number: 10145731
    Abstract: A performance testing device for a multi-channel tunable laser, comprising a collimating and coupling lens, a first beam splitter, a power testing unit, a side-mode suppression ratio testing unit, a wavelength testing unit and a control and drive unit, the power testing unit being positioned in a reflection path of the first beam splitter, the wavelength testing unit being positioned in a transmission path of the first beam splitter, the side-mode suppression ratio testing unit being positioned in a reflection path of the second beam splitter, the control and drive unit being in a control connection with the power testing unit, the side-mode suppression ratio testing unit and the wavelength testing unit. The performance testing device has a simple structure, a low cost, and is convenient to use.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: December 4, 2018
    Assignee: Accelink Technologies Co., Ltd.
    Inventors: Kun Qian, Yanfeng Fu, Xuesheng Tang, Yi Tang, Yizong Chen, Di Zhang, Shenglei Hu, Weidong Ma
  • Patent number: 10144964
    Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: December 4, 2018
    Assignee: DNAE Group Holdings Limited
    Inventors: Pantelis Georgiou, Samuel Reed, Yan Liu, Christofer Toumazou, Chung-Pei Ou
  • Patent number: 10139403
    Abstract: The invention provides a method of circulating magnetically responsive beads within a droplet in a droplet actuator. The invention also provides methods for splitting droplets. The invention, in one embodiment, makes use of a droplet actuator with top and bottom substrates, a plurality of magnetic fields respectively present proximate the top and bottom substrates, wherein at least one of the magnet fields is selectively alterable, and a plurality of droplet operations electrodes positioned along at least one of the top and bottom surfaces. A droplet is positioned between the top and bottom surfaces and at least one of the magnetic fields is selectively altered.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: November 27, 2018
    Assignee: ADVANCED LIQUID LOGIC, INC.
    Inventors: Vamsee K. Pamula, Ramakrishna Sista, Vijay Srinivasan, Michael G. Pollack, Allen Eckhardt
  • Patent number: 10120272
    Abstract: A fluorescent color wheel includes a substrate, a working fluid, and a fluorescent powder layer. The substrate has at least one flow channel therein. The flow channel has a first end and a second end respectively adjacent to a central region and a peripheral region of the substrate. The working fluid flows in the flow channel in a gas-liquid coexistence state. The fluorescent powder layer is disposed on the substrate and located at the peripheral region. The disclosure further discloses a projector adopting the fluorescent color wheel.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 6, 2018
    Assignee: DELTA ELECTRONICS, INC.
    Inventors: Keh-Su Chang, Yen-I Chou, Chi Chen
  • Patent number: 10113924
    Abstract: The development of a stress-responsive colorimetric film that can memorize the stress it has experienced is disclosed. The system can use the plasmonic shift associated with the disassembly of one-dimensional plasmonic nanoparticle chains driven by the plastic deformation of the surrounding polymer matrix. By modifying the plasticity of the polymer, the plasmonic shift and colorimetric change can respond to a large range of stresses. The pressure indicating film can be used to capture and record the pressure distribution and magnitude between two contacting or impacting surfaces by outputting color information.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 30, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yadong Yin, Xiaogang Han, Yiding Liu
  • Patent number: 10106846
    Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: October 23, 2018
    Assignee: Fluidigm Corporation
    Inventors: Marc A. Unger, Geoffrey Richard Facer, Barry Clerkson, Christopher G. Cesar, Neil Switz
  • Patent number: 10107720
    Abstract: A detection device (100) comprises a detecting chamber (32) containing a detecting element for analyzing whether a specimen containing an analyte, and an indicating element (8) displaying whether the detection is activated. The method for using the detection device (100) is also disclosed.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: October 23, 2018
    Assignee: Alere Switzerland GmbH
    Inventors: Christopher Tarpey, Mary Catherine Parsons, Lijian Gou, Haipeng Hu, Fei Gao, Yinfei Wu
  • Patent number: 10094893
    Abstract: Described herein are a magnetic resonance probe and a NMR, MRI, or EPR apparatus including the same. The magnetic resonance probe includes a conductor electrically coupled to the resonator and configured to transmit and receive electromagnetic radiation to and from a sample, wherein the conductor includes one or more cascaded narrowed regions along its longitudinal dimension and a slot within one of the one or more cascaded narrowed regions; and an electrical circuit coupled to the conductor and the resonator.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: October 9, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jianping Hu, Louis Bouchard
  • Patent number: 10078023
    Abstract: The development of a stress-responsive colorimetric film that can memorize the stress it has experienced is disclosed. The system can use the plasmonic shift associated with the disassembly of one-dimensional plasmonic nanoparticle chains driven by the plastic deformation of the surrounding polymer matrix. By modifying the plasticity of the polymer, the plasmonic shift and colorimetric change can respond to a large range of stresses. The pressure indicating film can be used to capture and record the pressure distribution and magnitude between two contacting or impacting surfaces by outputting color information.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: September 18, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yadong Yin, Xiaogang Han, Yiding Liu
  • Patent number: 10041863
    Abstract: Carbon dioxide levels in an open-container beverage are measured by transferring a quantity of the beverage to a vessel. A closure is secured onto the vessel to form an enclosed volume containing the beverage. A probe is inserted through the closure to contact the beverage, and a sample is transferred from the vessel to a measurement instrument to determine the carbon dioxide level. The methods allow for significantly greater precision and reliability in measuring carbonation levels of open-container beverages relative to currently available techniques.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: August 7, 2018
    Assignee: PepsiCo, Inc.
    Inventors: Aleksey Bakharev, Herriot Moise, Min Feng Zheng
  • Patent number: 10036737
    Abstract: An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: July 31, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroyuki Satake, Yuichiro Hashimoto, Masao Suga, Hideki Hasegawa
  • Patent number: 10031151
    Abstract: An analysis device for particle analysis, configured in such a manner that a reagent container is set in the device by inserting the reagent container from a side surface of the device toward the inside thereof, the reagent container having, near the forward end thereof, a suction pipe entrance portion into which a suction pipe can enter. The analysis device is provided with: a reagent container holding portion which holds the reagent container inserted from the suction pipe entrance portion side; and the suction pipe which enters, from above, the suction pipe entrance portion of the reagent container held by the reagent container holding portion and which sucks a reagent within the reagent container. The reagent container holding portion includes a guide member for guiding the insertion of the reagent container, which is inserted from the suction pipe entrance portion side, into the reagent container holding portion.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: July 24, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Takaaki Nagai, Yuichi Hamada, Nobuhiro Kitagawa
  • Patent number: 10018602
    Abstract: A number of analytes are divided into groups based on at least either the elution position determined by silica gel column chromatography under the same condition or the partition ratio in a hexane-acetonitrile partition method. To each group, a compound obtained by labeling one of the compounds in the group by deuterium and/or carbon is assigned as the surrogate. After those surrogates are added as internal standard substances to a standard sample for the creation of calibration curves, a GC/MS analysis for the sample is performed and a calibration curve is created for each analyte. In the measurement of an unknown sample, the same set of surrogates are added to the sample and the GC/MS analysis is performed. A quantitative determination processor determines the quantity of each analyte by comparing a peak area ratio calculated from the analysis result with a calibration curve read from the database.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: July 10, 2018
    Assignees: SHIMADZU CORPORATION, AICHI PREFECTURAL GOVERNMENT
    Inventors: Eiji Ueno, Riki Kitano, Haruhiko Miyagawa
  • Patent number: 10010852
    Abstract: A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: July 3, 2018
    Assignee: Genia Technologies, Inc.
    Inventor: Roger J. A. Chen
  • Patent number: 10014353
    Abstract: The present application discloses a substrate comprising a via and a lyophobic protrusion layer comprising a plurality of protrusions spaced apart in the via, each of the plurality of protrusions protruding from a bottom surface of the via.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: July 3, 2018
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Yingying Song, Li Sun
  • Patent number: 10012653
    Abstract: A composition is disclosed which is capable of being used for detection, comprising a noble metal nanoparticle. The inventive compositions exhibit little interaction with serum proteins while exhibiting pH-dependent adsorption onto live cell membranes. The nanoparticles of the claimed invention are capable of interacting with cell membranes, which in turn permits the advantages of nanoparticle bio-imaging to be extended to many pH dependent biological processes such as targeting acidic tumor microenvironment.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: July 3, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jie Zheng, Mengxiao Yu
  • Patent number: 9993819
    Abstract: An apparatus for actuating in rotation and reading a centrifugal microfluidic disk for biological and/or biochemical analyses, comprising: a container body, defining an internal chamber forming a closed curvilinear path, the path comprising a housing region configured to house the centrifugal microfluidic disk, and a curvilinear channel fluidically coupled to the housing region; a heater operatively arranged in a section of the curvilinear channel; and a fan operatively arranged in a respective section of the curvilinear channel.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: June 12, 2018
    Assignee: STMICROELECTRONICS S.R.L.
    Inventors: Enrico Rosario Alessi, Floriana San Biagio, Salvatore Abbisso, Salvatore Oliveri
  • Patent number: 9989542
    Abstract: A system for determining a level of a lipid analyte corrected for hematocrit includes a test strip configured to receive a sample and a meter configured to receive the test strip. The system further includes circuitry and a microprocessor, the circuitry and microprocessor configured to read the test strip and the sample and determine a level of a lipid analyte and correct the level of the lipid analyte based on a hematocrit level of the sample.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: June 5, 2018
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Gary L. Hughes, Robert Huffstodt, Keith Moskowitz
  • Patent number: 9983139
    Abstract: Embodiments described are generally directed to a test sample apparatus. The test sample apparatus generally comprises a holder base arranged that accommodates a tablet or cell phone. The apparatus has a hood that is placed over a portion of the tablets illuminating touchscreen such that the illuminating touchscreen provides light that can be collected by the hood. There is a chamber integrated with the hood adapted to accommodate a chemically activated test strip. The chemically activated test strip is illuminated when the hood collects light from the illuminating touchscreen. A lens in the hood interposed between the camera and the test strip enables the camera to focus on a portion of the chemically activated test strip when the hood is placed over the portion of the illuminating touchscreen.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 29, 2018
    Inventor: Donald Channing Cooper
  • Patent number: 9976962
    Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: May 22, 2018
    Assignee: Charm Sciences, Inc.
    Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
  • Patent number: 9952210
    Abstract: A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner. The specimen material solution that has been sent may pass through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: April 24, 2018
    Assignee: KONICA MINOLTA, INC.
    Inventors: Noriaki Yamamoto, Youichi Aoki
  • Patent number: 9949674
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 24, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Tian-Xian Zhao, Paul Glavina
  • Patent number: 9937499
    Abstract: In a first aspect, the present invention provides a handgrip configured to extract an analysis strip from a groove of an analyser. The handgrip comprises a casing piece configured to be attached with the analyser, and a retaining piece having a retaining portion. The retaining piece is movable with respect to the casing piece in such a way that the retaining portion is movable in a first direction from a proximal position to a distal position relative to the casing piece. The retaining portion is configured to retain the analysis strip during at least part of its movement from the proximal to the distal position, and to avoid retaining the analysis strip at least when the retaining portion is in any of the proximal and distal positions.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: April 10, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Andrea González Fernández, Bartomeu Ventayol Femenias
  • Patent number: 9927387
    Abstract: An auto-calibration system for diagnostic test strips is described for presenting data individually carried on each test strip readable by a diagnostic meter. The test strip meter may provide a predetermined varying resistance on one strip or a plurality of varying resistances from strip lot to strip lot.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 27, 2018
    Assignee: Trividia Health, Inc.
    Inventors: Gary T. Neel, Brent E. Modzelewski, Allan Javier Caban, Adam Mark Will, Carlos Oti
  • Patent number: 9928587
    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain encoding information, so as to preserve confidentiality.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: March 27, 2018
    Assignee: BioArray Solutions, Ltd.
    Inventors: Michael Seul, Xiongwu Xia, Chiu Chau, Scott Determan
  • Patent number: 9891189
    Abstract: Techniques for fabricating horizontally aligned nanochannels are provided. In one aspect, a method of forming a device having nanochannels is provided. The method includes: providing a SOI wafer having a SOI layer on a buried insulator; forming at least one nanowire and pads in the SOI layer, wherein the nanowire is attached at opposite ends thereof to the pads, and wherein the nanowire is suspended over the buried insulator; forming a mask over the pads, the mask having a gap therein where the nanowire is exposed between the pads; forming an alternating series of metal layers and insulator layers alongside one another within the gap and surrounding the nanowire; and removing the nanowire to form at least one of the nanochannels in the alternating series of the metal layers and insulator layers. A device having nanochannels is also provided.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: February 13, 2018
    Assignee: International Business Machines Corporation
    Inventors: Sebastian U. Engelmann, Stephen M. Rossnagel, Ying Zhang
  • Patent number: 9885731
    Abstract: A medical tested object auto-ejection structure comprises a detection instrument and a tested object (1). An insertion port is formed in the detection instrument. When the tested object (1) is inserted in the instrument through the insertion port, the bottom end of the tested object (1) presses a bulge (21) used for rebounding, and a raised step (11) arranged on the surface of one side of the tested object (1) is locked on a clamping buckle (31) arranged at a position corresponding to the step on the instrument simultaneously, and after a test is finished, the instrument releases the locking of the clamping buckle (31) for the tested object (1) by a transmission device, and the tested object (1) is ejected from the instrument in time under the action of the bulge (21) used for rebounding, thus solving the problem of forgetting to pull the tested object out or inability to pull it out in time, and improving the reliability of the product.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: February 6, 2018
    Assignee: EDAN INSTRUMENTS, INC.
    Inventors: Gaoxiang Huang, Zhixiang Zhao