Means For Analyzing Liquid Or Solid Sample Patents (Class 422/68.1)
  • Patent number: 11067523
    Abstract: A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed. The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: July 20, 2021
    Assignee: SONY CORPORATION
    Inventor: Yoshihito Hayashi
  • Patent number: 11061013
    Abstract: This disclosure comprises devices and methods for determining the identity of individual protein molecules in a complex mixture by unfolding the protein into a polypeptide, tagging selected residues on the polypeptide with selected oligonucleotide sequence tags that recognize selected residues on said polypeptide, and then detecting the oligonucleotide sequence tags.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: July 13, 2021
    Inventor: Kalim Mir
  • Patent number: 11060958
    Abstract: A sample preparation system includes a sample input, a first chamber fluidly coupled to the sample input and containing a sample preparation reagent, a second chamber containing a surface enhanced Raman spectroscopy (SERS) sensor structure and a third chamber containing a sensor preparation solution. The sample input, the first chamber and the second chamber are fluidly coupled to one another in a series and the third chamber is fluidly coupled to the third chamber outside of the series so as to sequentially direct a sample received by the sample input through the first chamber to the second chamber and out of the second chamber and so as to direct the sensor preparation solution into the second chamber following discharge of the sample out of the second chamber.
    Type: Grant
    Filed: February 27, 2016
    Date of Patent: July 13, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Anita Rogacs
  • Patent number: 11041870
    Abstract: An automated analysis device includes a reagent disc on which a plurality of reagent containers are loaded; a reagent loader that loads a reagent from the outside onto the reagent disc and carries a reagent to the outside; a display unit that displays the reagents in the plurality of reagent containers, so as to be paired with corresponding analysis items for which the reagents are used; and a control unit that causes the reagent loader to simultaneously carry, to the outside of the reagent disc, a reagent which is selected, on the display unit, by an operation device used for an operation input from an operator instructing the reagent loader to take out the reagent and simultaneously carry a reagent which is to be used for a different analysis item to be performed simultaneously with the analysis item for the selected reagent.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: June 22, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Satoshi Yokotsuka, Toshiharu Suzuki, Rira Okashita
  • Patent number: 11035497
    Abstract: Provided is a centrifugal valve control apparatus including: a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel; a heating part coupled to the body and including a heating member disposed at a position corresponding to the valve; and a rotation driving part configured to rotate the body part and the heating part together, wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together. Accordingly, the valve of the centrifugal valve control apparatus may be accurately controlled.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 15, 2021
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventor: Min Seok Kim
  • Patent number: 11037912
    Abstract: A multi-color LED display comprises pixels, each comprising a first sub-pixel, a second sub-pixel, and a third sub-pixel. The first sub-pixel comprises a first light-emitting diode (LED) that emits a first color of light, the second sub-pixel comprises second LEDs that emit a second color of light different from the first color of light, and the third sub-pixel comprises third LEDs that emit a third color of light different from the first color of light and different from the second color of light. The second LEDs are electrically connected in parallel and the third LEDs are electrically connected in series.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: June 15, 2021
    Assignee: X Display Company Technology Limited
    Inventors: Matthew Alexander Meitl, Christopher Andrew Bower, Ronald S. Cok, Brook Raymond
  • Patent number: 10969904
    Abstract: The present application discloses a noise detecting method and apparatus, and an electronic device, the method includes: obtaining a noise of each sensing electrode of a plurality of sensing electrodes of a touch screen at a current operating frequency point during an operation of the touch screen; calculating a difference between the noise of the sensing electrode and a current noise reference of the sensing electrode to obtain a noise difference of the sensing electrode; performing differential processing on the noise differences of the sensing electrode and a noise difference of an adjacent sensing electrode of the sensing electrode, to obtain a first processing result comprising a plurality of values, and comparing a maximum value of the first processing result with a preset first threshold; if the maximum value is greater than the threshold, determining that there is noise interference at the current operating frequency point.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: April 6, 2021
    Assignee: SHENZHEN GOODIX TECHNOLOGY CO., LTD.
    Inventor: Haikuan Jiang
  • Patent number: 10930481
    Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 23, 2021
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Linfan Li, Xiaoyu Zhou
  • Patent number: 10921337
    Abstract: The purpose of the present invention is to provide an automatic analyzing device capable of carrying in/out a reagent suitable for the intended use of a user according to the state of the device. An automatic analyzing device has a reagent refrigerator for movably holding reagent containers and a reagent loader for carrying in/out the reagent containers to/from the reagent refrigerator through movement in a direction perpendicular to the reagent refrigerator. A reagent refrigerator cover covers an upper surface of the reagent refrigerator and has an opening through which the reagent loader can pass. A storage unit stores a device state of the automatic analyzing device and a reagent-carry-in/out-method is selected on the basis of the device state. A control unit controls the reagent holder and the reagent loader according to the selected reagent carry-in/out method so as to carry in/out a target reagent container.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: February 16, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Hiroki Fujita, Toshiharu Suzuki, Takaaki Hagiwara
  • Patent number: 10870114
    Abstract: A microfluidic system includes: an electro-wetting on dielectric (EWOD) cartridge having an element array configured to receive liquid droplets, the element array including individual array elements each including array element circuity comprising sensing circuitry that is integrated into the array element circuitry; a microfluidic instrument that is configured to receive the EWOD cartridge and having an electrically conductive locator that is external to the EWOD cartridge; and a control system configured perform electrowetting operations by controlling actuation voltages applied to the element array to perform manipulation operations as to liquid droplets present on the element array. The control system further is configured to read an output from the sensing circuitry, determine a position of the locator relative to the element array based on the output, and determine a misalignment of the EWOD cartridge relative to the microfluidic instrument based on the position of the locator.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 22, 2020
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Benjamin James Hadwen, Oliver James Beard, Chris Clarke
  • Patent number: 10871486
    Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 22, 2020
    Assignee: i-calQ, LLC
    Inventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
  • Patent number: 10865436
    Abstract: A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: December 15, 2020
    Assignee: RHEONIX, INC.
    Inventor: Peng Zhou
  • Patent number: 10842238
    Abstract: Disclosed herein is an electronic device encasement which not only encases and protects the electronic device, it allows for storage and presentation of one or more data cards. As the encasement device operator initiates access to the stored data card by opening a protective storage cover, the accessing action initiates a subsequent mechanical response which presents the card by a separating action from the encasement and the other possible stored items, as to allow for easier access and use of the one or more data cards. The storage and presentment mechanisms include a plurality of pockets, grips, and other structures to secure and present the cards.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 24, 2020
    Assignee: Fellowes Mobile LLC
    Inventors: Harsh Gandhi, Benjamin MacBeth, Jeffrey Lienemann, Richard Kang, Tai Hoon K. Matlin, Steve Carson
  • Patent number: 10838939
    Abstract: Disclosed herein are nucleic acid-based data storage systems and nucleic acid data storage constructs comprising reusable nucleic acid sequences, each representing information carried by a single bit (and, in some embodiments, one or more adjacent bits) within a bit string, and each furthermore representing the position of the single bit within the bit string. Also described are methods for storing data in the nucleic acid-based data storage systems and nucleic acid data storage constructs of the disclosure.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: November 17, 2020
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Joseph Alan Walder, Jeffrey A. Manthey, William E. Martin, III, Shawn Allen
  • Patent number: 10822528
    Abstract: A protective layer for use on a sensor during a manufacturing process avoids damage to the sensor and keeps the sensor surface clean during lens fabrication. The protective layer includes a non-cross-linked, water-soluble polymer layer and an anhydrous, cross-linkable, methacrylate-based formulation layer, temporarily applied to a surface of the sensor. The protective layer may be used to protect the sensor during a manufacturing process by applying the non-cross-linked, water-soluble polymer layer and the anhydrous, cross-linkable, methacrylate-based formulation layer consecutively onto the surface of the sensor to form the protective layer; affixing the sensor to a substrate; fabricating a device that includes the substrate; and subsequently removing the protective layer from the surface of the sensor.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: November 3, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Parissa Heshmati, Jeffrey G. Linhardt, Brian Alvarez, Hojr Pisheh
  • Patent number: 10816455
    Abstract: Aspects of the present disclosure include methods and systems for detecting light from a sample in a flow stream by multi-photon counting. Methods according to certain embodiments include irradiating a sample in a flow stream with a light source and detecting light from the sample in the flow stream and counting photons of the detected light by integrating photo-electron charge over a time interval. Methods also include irradiating a sample in a flow stream with a light source, detecting light from the sample in the flow stream and outputting a digital output signal and an analog output signal produced by the detected light. Systems for detecting light from a sample in a flow stream with a detector and counting photons by integrating photo-electron charge over a time interval are also described. Kits having a detector, a photon counter and a flow cell configured to propagate a sample in flow stream are also provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: October 27, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Jianying Cao, Wei Chen
  • Patent number: 10786800
    Abstract: A method and system for heating and/or inspecting a portable microfluidic assay cartridge for performing an assay includes receiving the assay cartridge on a receiving region of a translatable table under automated control, heating the cartridge, during performance of the assay, with a planar radiant heater plate, the heater plate having an aperture through which an inspection axis extends, and/or inspecting the cartridge using an optical system constructed to inspect the cartridge along the inspection axis by reading a fluorescent light signal which passes through the aperture in the heater plate. In addition, the cartridge moves with movement of the translation table, and the heater plate and optical system may be stationary, and the inspection axis may be fixed.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: September 29, 2020
    Assignee: CyVek, Inc.
    Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood
  • Patent number: 10788469
    Abstract: A mass spectrometry data processor (2) having a database (21) for storing respective pieces of mass spectrum data of various compounds together with names and mass spectrometry conditions of the compounds includes a mass spectrum data receiver (22) configured to receive input of mass spectrum data associated with a compound name and a mass spectrometry condition, a determination unit (25) configured to determine whether the mass spectrum data includes a mass peak satisfying a predetermined criterion, and a database registration unit (31) that registers, on the database, mass spectrum data determined to include the mass peak satisfying the predetermined criterion or mass spectrum data based on the mass spectrum data determined to include the mass peak satisfying the predetermined criterion together with a compound name and a mass spectrometry condition.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: September 29, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Yutaro Yamamura, Toshikazu Minohata
  • Patent number: 10787947
    Abstract: A fluid sensor protection assembly for protecting a fluid sensor comprises a housing receiving the fluid sensor. The housing includes a bottom wall having a lower inner flow-through opening, a top wall spaced apart from the bottom wall in a vertical direction and having an upper inner flow-through opening, a lower cover member covering the lower inner flow-through opening on an outside of the housing, and an upper cover member covering the upper inner flow-through opening on the outside of the housing. The lower cover member is spaced apart from the lower inner flow-through opening in the vertical direction and forms a lower outer flow-through opening. The upper cover member is spaced apart from the upper inner flow-through opening in the vertical direction and forms an upper outer flow-through opening. A continuous flow-through passage through the housing extends between the lower outer flow-through opening and the upper outer flow-through opening.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: September 29, 2020
    Assignee: MEAS France
    Inventors: Dariga Toulon-Meekhun, Vincent Leger, Gael Chavarria
  • Patent number: 10770281
    Abstract: An ion trap includes: an ion trap including a plurality of electrodes; a rectangular voltage generator including a voltage source for generating a direct voltage and a switching section, the rectangular voltage generator configured to operate the switching section to generate a rectangular voltage by switching the direct voltage generated by the voltage source and to apply the rectangular voltage to at least one of the plurality of electrodes; and a switching section temperature controller configured to control a temperature of the switching section so as to maintain the temperature of the switching section at a target temperature which is higher than a highest reaching temperature of the switching section.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 8, 2020
    Assignee: Shimadzu Corporation
    Inventor: Makoto Hazama
  • Patent number: 10761012
    Abstract: Computer-implemented methods and computer-readable media are disclosed for providing a spectroscopic film selection tool to select one or more of a plurality of films for use in a spectroscopic analysis. At a first computing system, a spectroscopic film selection tool is stored in a non-transitory storage medium. The spectroscopic film selection tool includes a set of machine-readable instructions configured to execute on a second computing system. The machine-readable instructions are configured to elicit user input regarding attributes of a spectroscopic analysis and, based on the user input, identify one or more of a plurality of films for use in a spectroscopic analysis based on film data for each of the plurality of films.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: September 1, 2020
    Inventor: Michael C. Solazzi
  • Patent number: 10746702
    Abstract: Method of tuning parameter settings for performing acoustic scanning probe microscopy for subsurface imaging, scanning probe microscopy system, and computer program product. This document relates to a method of tuning a scanning probe microscopy system. The method comprises: a) applying an acoustic vibration signal comprising a first frequency and a second frequency to a sample; b) at a first position of the probe tip, sweeping the first frequency across a first frequency range, and obtaining a first signal; c) at a second position of the probe tip, sweeping the first frequency across at least said first frequency range, and obtaining a second signal; d) analyzing the first and second signals to obtain a difference characteristic dependent on the first frequency. The first and second position are selected such that a subsurface structure of the sample at the first and second position is different.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: August 18, 2020
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventors: Hamed Sadeghian Marnani, Rutger Meijer Timmerman Thijssen, Maarten Hubertus van Es
  • Patent number: 10745749
    Abstract: The present invention provides methods for detecting the presence or absence of a nucleic acid variant in a target region. These methods include amplifying the target region with a forward primer and a reverse primer in the presence of a selector blocker. The selector blocker includes a sequence complementary to the target region in the absence of the nucleic acid variant. The methods further include detecting amplification of the target region where amplification of the target region indicates the presence of the nucleic acid variant in the target region. The nucleic acid variant can include deletions, mutations or insertions.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 18, 2020
    Assignees: Biocept, Inc., Aegea Biotechnologies
    Inventor: Lyle Arnold
  • Patent number: 10745393
    Abstract: The present disclosure relates to compounds which function as small molecule fluorescent probes which aid in recognition of specific sequences in DNA and detection of A? aggregates. Probes/dyes of the instant disclosure are specific to AT-rich sequences of DNA and A? aggregates. These small organic dyes/probes are capable of exhibiting switch-on fluorescence and play an important role in fluorescence spectroscopy, diagnostics, imaging and biomedical applications.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: August 18, 2020
    Assignee: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
    Inventors: Govindaraju Thimmaiah, Nagarjun Narayanaswamy, Kolla Rajasekhar
  • Patent number: 10748369
    Abstract: A credit card reader that is configurable for use is provided that includes a first assembly and a second assembly. The first assembly has a mag stripe card reader. The second assembly has a Europay Mastercard Visa (EMV) reader. The second assembly is coupled to the first assembly, where the first assembly rotates about an axis perpendicular to a plane in which the assemblies are disposed to one of a plurality of angular positions, the plurality of angular positions indicating an offset angle of the first assembly relative to the second assembly.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 18, 2020
    Assignee: TOAST, INC.
    Inventors: Gaurav Nakhare, Boon Ping Ng
  • Patent number: 10732162
    Abstract: The present invention relates to a method for determining the disintegration time of a film-shaped pharmaceutical dosage form and a disintegration testing device for use in such a method.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: August 4, 2020
    Assignee: Hexal AG
    Inventors: Jörg Nink, Josef Pichler, Katharina Obermüller, Alexander Wotzko
  • Patent number: 10732095
    Abstract: A particle imaging device comprises a flow cell, a light source, an irradiation optical system configured to form a light sheet on the flow cell, a light collecting optical system and an imaging element. The sheet surface of the light sheet is perpendicular to the exterior side surface of the flow cell to which the light is entered from the light source. The sheet surface of the light sheet is inclined at a predetermined angle that is not perpendicular to the flow direction of the sample.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 4, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Patent number: 10717926
    Abstract: An atom, molecule, atomic layer molecular layer is adhered to a carbon nanotube surface, or the surface is doped with the atom, molecule, atomic layer, or molecular layer, to form a deep localized level so that an exciton is localized. Alternatively, an atom, molecule, inorganic or organic substance of an atomic or molecular layer, a metal, a semiconductor, or an insulator is absorbed to, deposited on, or encapsulated in the carbon tube inside surface to make permittivity of the portion undergoing the absorption, deposition, or encapsulation higher than that of a clean portion free of the absorption, deposition, or encapsulation so that binding energy of the exciton in the clean portion is high, or reduce a band gap of the portion undergoing the absorption, deposition, or encapsulation so that the exciton is confined and localized in the clean portion or the position undergoing the absorption, deposition, or encapsulation.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: July 21, 2020
    Assignee: KEIO UNIVERSITY
    Inventor: Hideyuki Maki
  • Patent number: 10712284
    Abstract: The present invention relates to a method for grafting, in a covalent manner, a coloured indicator having at least one aromatic primary amine function onto the surface of a solid substrate, including the steps that consist of: (a) preparing, from the coloured indicator having at least one aromatic primary amine function, the corresponding diazonium salt; (b) placing the solid substrate in contact with a solution containing the diazonium salt prepared in step (a) and subjecting the solution to non-electrochemical conditions for an optimal grafting time whereby organic chains in which the units are derivatives of the diazonium salt are grafted, in a covalent manner, onto the surface of the solid substrate; (c) washing the solid substrate thus grafted; (d) repeating steps (b) and (c) or possibly steps (a) to (c) at least once. The present invention also relates to a kit for implementing such a method.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: July 14, 2020
    Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Denis Doizi, Guy Deniau, Mathias Fages
  • Patent number: 10712272
    Abstract: Methods and corresponding apparatus and systems for assessing cellular metabolic activity are disclosed. In one aspect, a cell can be illuminated with optical radiation in order to cause multi-photon excitation of at least one endogenous metabolic cofactor in that cell and cause the excited metabolic cofactor to emit fluorescent radiation. A detector can be used to detect the fluorescent radiation emitted by the excited endogenous metabolic cofactor. A computer processor can analyze the fluorescent radiation to derive the following parameters: (1) using a computer processor to analyze the intensity of the fluorescent radiation, (2) a fluorescence lifetime of at least one of the excited metabolic cofactor, (3) a parameter indicative of mitochondrial clustering in the cell. These parameters can be used to assess at least one metabolic process of the cell.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: July 14, 2020
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: Irene Georgakoudi, Dimitra Pouli, Kyle P. Quinn, Zhiyi Liu
  • Patent number: 10702868
    Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: July 7, 2020
    Assignee: National Research Council of Canada
    Inventors: Teodor Veres, Daniel Brassard, Liviu Clime, Francois Normandin
  • Patent number: 10692388
    Abstract: Provided is an engine health management system and method for determining health of an engine of an aircraft, that includes a data source interface which transmits data from internal and external data sources, a control module that includes a processor and a memory and receives data via the data source interface, creates evaluation methods for evaluating the data received to determine suitable data and storing the suitable data within the memory, and creates a controlled historical airport information repository to process historical data via the processor and generate airport information reports based on the historical data. The system also includes a central computing system communicatively coupled with the control module and the data source interface, which performs data enhancement techniques including linking environmental counts and accumulations with engine data.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 23, 2020
    Assignee: General Electric Company
    Inventors: Andrew Scott Kessie, Michael H. Fisher, Daniel Maggard, Byron Andrew Pritchard
  • Patent number: 10684299
    Abstract: This disclosure concerns a method and a system for quality evaluation of a handheld analytical device, wherein the device is operable by a human user in a sequence of handling steps to test an analyte in a sample fluid applied on a test element, the method comprising the steps of (a) programming a handling cycle for a robot having at least one robot arm in order to mimic the sequence of handling steps, (b) operating the device in at least one handling cycle by means of the robot, (c) monitoring the operation in step (b) by a control unit to evaluate at least one parameter influencing the quality of the device.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: June 16, 2020
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Wolfgang Schwoebel
  • Patent number: 10675629
    Abstract: A point of use analyzer includes pump, valve, port, and storage channel. The storage channel may hold multiple assay packets composed of reagent aliquots separated by bounding slugs. The storage channel may define an elongated lumen having two ends with each of the ends coupled to the valve. A sampling device for use with the analyzer engages the port and may include a recurrent coaxial tube having a separation medium. A method of using the analyzer with the sampling device includes steps of pumping a fluid to displace a sample into the separation medium and out through the opposed connection.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 9, 2020
    Inventor: Michael L. Bell
  • Patent number: 10678914
    Abstract: This disclosure relates to detection of viruses. In one implementation, a virus detection method performed by a terminal device is disclosed. The method may include obtaining a full characteristic features of a first file, the first file being a sample file collected by a client application of the terminal device, and the full characteristic features of the first file being used to uniquely determine all components of the first file, obtaining a first binary hash sequence based on the full characteristic features of the first file and by using a preset hash algorithm, calculating similarity parameters between the first binary hash sequence and reference binary hash sequences in an antivirus database, each binary hash sequence in the antivirus database corresponding to one type of virus-infected file, and determining the first file as a virus-infected file when at least one of the similarity parameters is less than a preset similarity threshold.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: June 9, 2020
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventor: Jingwei Lei
  • Patent number: 10677780
    Abstract: Compositions, kits, and devices that include calibration and/or quality control reagent(s) for monitoring the performance of blood gas, electrolyte, and/or metabolite instrumentation are disclosed. Different oxygen levels in the calibration and/or quality control reagent(s) can be generated using an oxygen scavenger. Methods of accurately measuring the oxygen levels so generated using a by-product of the oxygen scavenger are also disclosed.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: June 9, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Bong Oh
  • Patent number: 10670596
    Abstract: It is an object of the present invention to provide improved methods and compositions for manufacture and use of lateral flow test devices. In particular, the present invention provides a molding method which provides one or more features in the housing base configured to retain the test strip within the base. These features are provided as undercuts in the housing base. The test strip is configured as a bibulous lateral flow material disposed on a substantially non-compressible base layer, and the base layer is positioned within the undercut in order to retain the test strip in the housing base. Optionally, one or more features in the housing base which create the undercut are configured to engage the bibulous lateral flow material by compression and/or friction, thereby increasing the ability of the base to maintaining the test strip in its proper position within the device.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: June 2, 2020
    Assignee: Astute Medical, Inc.
    Inventors: Joseph Anderberg, John Van Bosch
  • Patent number: 10663420
    Abstract: The present invention is directed to a sensor having continuous and discontinuous regions of conductive metallic nanoparticles capped with an organic coating which enables the detection of volatile organic compounds and/or water vapor. Continuous regions may exhibit a positive response upon exposure to volatile organic compounds and to water vapor, while discontinuous regions exhibit a negative response upon exposure to water vapor larger than the positive response of the continuous region.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: May 26, 2020
    Assignee: Technion R&D Foundation Ltd.
    Inventors: Hossam Haick, Meital Segev-Bar, Gregory Shuster, Sagi Gliksman
  • Patent number: 10656059
    Abstract: A method for qualitative and quantitative multiplexing of drug analytes from dried blood samples includes the steps of mixing an Internal Standard solution with a first diluent in a vessel, adding the dried blood sample to the vessel, sonicating the vessel containing the Internal Standard solution, the first diluent and the dried blood sample, removing the dried blood sample from the vessel so that a final sample can be attained, and analyzing at least a portion of the final sample using one of LC-MS and LC-MS/MS to simultaneously determine the presence or absence of a plurality of different analytes in the dried blood sample. The Internal Standard solution can include at least 8, 15, 25 or 50 Internal Standards. The dried blood sample is generated using less than 50 ?L, 20 ?L or 10 ?L of blood. The step of analyzing includes simultaneously determining the presence or absence of at least 15, 60, 90 or 130 different analytes.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: May 19, 2020
    Assignee: ALCALA PHARMACEUTICAL, INC.
    Inventors: David J. Smith, Matthew D. Rifat, Christian Tagwerker, Irfan Baig, Ranulu Samanthi de Zoysa, Eric J. Brunson
  • Patent number: 10641698
    Abstract: The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (CBC) testing. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing blood cells in a sample.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 5, 2020
    Assignee: CYTOCHIP INC.
    Inventors: Wendian Shi, Yuzhe Ding
  • Patent number: 10631965
    Abstract: A whitening smart pen apparatus (10) for automatically dispensing a teeth whitening substance onto one or more teeth of a user comprises a fluid reservoir (16), a nozzle (18) having an output port (26), a fluid dispenser (20), a sensor (22) and a controller (24). The fluid dispenser dispenses the teeth whitening substance from the fluid reservoir to the nozzle and is output via the output port. The sensor, positioned in an advance dispensing direction of the nozzle, senses a target surface that comprises either (i) a tooth surface (12) or (ii) other surface (14). The controller (24) is configured for (i) controlling a gating of the fluid dispenser (20) to dispense the teeth whitening substance from the fluid reservoir (16) in response to the sensor (22) detecting the tooth surface (12), and (ii) stopping or disabling the gating of the fluid dispenser to stop or disable a dispensing of the teeth whitening substance from the fluid reservoir in response to the sensor (22) detecting the other surface (14).
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: April 28, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Vincent Jeanne, Meng Peng, Jianxun Feng, Wan-Tzu Chen, Evan Dak Wah Dengler, Sungsoo Lee
  • Patent number: 10619151
    Abstract: A method for extracting a nucleic acid from a sample liquid comprises providing a heating element and providing an extraction nucleic acid that is bound to the heating element and/or providing the extraction nucleic acid such that the extraction nucleic acid binds to the heating element. The extraction nucleic acid is at least partly complementary to the nucleic acid. The method further comprises bringing the heating element into contact with the sample liquid such that the nucleic acid at least partly binds to the extraction nucleic acid, and separating the heating element from the sample liquid such that the nucleic acid bound to the extraction nucleic acid remains at the heating element. Additionally, the method comprises bringing the heating element into contact with a reaction solution, and heating the heating element to at least a denaturing temperature of the nucleic acid.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: April 14, 2020
    Assignee: GNA BIOSOLUTIONS GmbH
    Inventors: Joachim Stehr, Lars Ullerich, Federico Bürsgens, Domenik Zistl, Simon Schmidbauer, Daniel Grodd, Cecilia Rebuffo-Scheer, Lidiya Osinkina
  • Patent number: 10620199
    Abstract: A sensing sensor includes a wiring board, a piezoelectric resonator, and a gel-like protective agent. The piezoelectric resonator has one surface side on which an adsorbing film is formed. The adsorbing film is constituted of biomolecules. The protective agent is disposed so as to cover a surface of the adsorbing film. The protective agent is configured to suppress an inactivation of the biomolecules. The channel forming member is disposed so as to cover a region of the one surface side of the wiring board including the piezoelectric resonator. The channel forming member includes an injection port of the sample solution. The flow passage is disposed between the wiring board and the channel forming member. The flow passage is configured to allow the sample solution supplied to the injection port to flow from one end side to another end side on the one surface side of the piezoelectric resonator.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 14, 2020
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventor: Wakako Shinobu
  • Patent number: 10613082
    Abstract: Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: April 7, 2020
    Assignee: i-calQ, LLC
    Inventor: Joel R. L. Ehrenkranz
  • Patent number: 10615017
    Abstract: A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for CIDs in respective stages. If an MS1 spectrum on which CID is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage CID exists on the MS1 spectrum, based on the list held in the memory unit. If the ion exists, an MS2 analysis in which the ion is set as a precursor ion is immediately executed. Subsequently, the precursor ion selector determines whether or not an ion registered as a precursor ion for the second-stage CID in association with the precursor ion for the first-stage CID exists on an MS2 spectrum. If the ion exists, an MS3 analysis in which the ion is set as a precursor ion is immediately executed, so that an MS3 spectrum is acquired.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: April 7, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Tairo Ogura
  • Patent number: 10604755
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotides of a Lipid transport and metabolism gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a Lipid transport and metabolism genes.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 31, 2020
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman, Carlos Coito
  • Patent number: 10605815
    Abstract: The present invention provides a full-automatic feces analyzer, comprising an automatic controller; at least one sample box for containing a feces sample; a sample box support for placing the sample box; a dilution and stirring unit for adding diluent into the feces sample in the sample box and performing stirring to obtain feces sample liquid; a physical detection unit for performing a physical detection on the feces sample liquid; at least one chemical detection unit for performing a chemical detection on the feces sample liquid, each chemical detection unit comprising a driving roller and a driven roller, a reagent strip roll being wound on the driven roller, an end portion of the reagent strip roll being fixed on the driving roller, and the reagent strip roll comprising a plurality of reagent strips which are abreast distributed and sequentially connected; and a sample sucking and adding unit for sucking the feces sample liquid and delivering the feces sample liquid to the physical detection unit and the
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 31, 2020
    Assignee: SUZHOU HALO BIO-TECH CO., LTD.
    Inventor: Xianglong Li
  • Patent number: 10605804
    Abstract: Disclosed is an analysis method including: moving a complex, by means of a magnet unit, in a flow path of a specimen cartridge which includes the flow path and a detection vessel, the complex containing a test substance formed on magnetic particles and a labeled substance binding to the test substance; taking an image of the magnetic particles in the specimen cartridge; and measuring a label of the labeled substance contained in the complex in the detection vessel.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kosuke Jitsuhara, Jianyin Lu
  • Patent number: 10603667
    Abstract: Provided are a device and a cleaning mechanism for a reaction container in the device that are characterized by being provided with: a reaction disk for holding a reaction container; a sample dispensing mechanism for dispensing a sample to the reaction container; a reagent dispensing mechanism for dispensing a reagent to the reaction container; an optical system comprising a light source for applying light to a mixture of the sample and the reagent dispensed to the reaction container, and a detector for detecting the light applied from the light source; and a cleaning mechanism for cleaning the reaction container, wherein the cleaning mechanism is provided with a cleaning liquid supply nozzle for supplying a cleaning liquid to the reaction container after an analysis, a cleaning liquid suction nozzle for suctioning the supplied cleaning liquid, and a cleaning tip provided on the lower end of the cleaning liquid suction nozzle, and the side surface of the cleaning tip is formed such that the width of the clean
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kei Shioya, Masahiko Iijima
  • Patent number: 10598675
    Abstract: The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: March 24, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball