Means For Analyzing Liquid Or Solid Sample Patents (Class 422/68.1)
  • Patent number: 11415551
    Abstract: Various embodiments of an apparatus for measuring binding kinetics of an interaction of an analyte material present in a fluid sample are disclosed. The apparatus includes a sensing resonator having at least one binding site for the analyte material; actuation circuitry adapted to drive the sensing resonator into an oscillating motion; measurement circuitry coupled to the sensing resonator and adapted to measure an output signal of the sensing resonator representing resonance characteristics of the oscillating motion of the sensing resonator; and a controller coupled to the actuation and measurement circuitry, wherein the controller is adapted to detect an individual binding event between the at least one binding site and a molecule of the analyte material.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: August 16, 2022
    Assignee: Qorvo Biotechnologies, LLC
    Inventor: James Webster
  • Patent number: 11408901
    Abstract: The present invention relates to a strip for measuring blood lipids. The strip for measuring blood lipids, of the present invention, presses, with an optimal pressure or to an optimal height, a contact surface of a protruding part of a measurement layer disposed between an upper cover and a lower substrate, so as to improve the uniform diffusion of a biological sample, thereby having an effect of increasing measurement result accuracy of the biological sample.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 9, 2022
    Inventors: Kyung Hwan Hyun, Jung Hyun Lee, Gi Wook Kim
  • Patent number: 11391748
    Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 19, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
  • Patent number: 11391749
    Abstract: This disclosure provides a gene chip comprising a substrate and at least one positioning device fixed on an upper surface of the substrate, wherein the at least one positioning device is provided with a receiving cavity for receiving a bead, the receiving cavity being arranged on a surface of the at least one positioning device facing away from the substrate, and a cross-sectional area of the receiving cavity is gradually decreased in a direction toward the upper surface of the substrate. This disclosure further provides a gene detection device comprising the gene chip.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 19, 2022
    Inventors: Song Yang, Ming Zhu, Shiyu Zhang, Jiahui Han, Zheng Fang, Ge Shi, Haijun Niu, Yujie Liu, Yuyao Wang
  • Patent number: 11386552
    Abstract: A specimen analysis system includes at least one processor to receive image information that represents a respective plurality of pixels of an image of each of a plurality of testing areas to indicate the presence or absence of a test subject compound; to determine for each testing area a number of pixels that indicates either the presence or the absence of the test subject compound, if the number of pixels indicating positive for each of a plurality of testing areas equals or exceeds a first minimum threshold value indicating that the testing area is positive for either the presence or absence of the test subject compound, totaling all testing areas indicating positive for either the presence or absence of the test subject compound, and if the total number of the testing areas indicating positive for either the presence or absence of the test subject compound equals or exceeds a second minimum threshold value indicating an overall positive test result for either the presence or absence of the test subject co
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 12, 2022
    Assignee: GENPRIME, INC.
    Inventors: Michael Arthur Russell, Jason Buck Somes, Darby Dawn McLean, Claire Elizabeth Norton
  • Patent number: 11378545
    Abstract: A semiconductor structure capable of real-time spatial sensing of nanoparticles within a nanofluid is provided. The structure includes an array of gate structures. An interlevel dielectric material surrounds the array of gate structures. A vertical inlet channel is located within a portion of the interlevel dielectric material and on one side of the array of gate structures. A vertical outlet channel is located within another portion of the interlevel dielectric material and on another side of the array of gate structures. A horizontal channel that functions as a back gate is in fluid communication with the vertical inlet and outlet channels, and is located beneath the array of gate structures. A back gate dielectric material portion lines exposed surfaces within the vertical inlet channel, the vertical outlet channel and the horizontal channel.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: July 5, 2022
    Assignee: International Business Machines Corporation
    Inventors: Kangguo Cheng, Ali Khakifirooz, Ghavam G. Shahidi, Davood Shahrjerdi
  • Patent number: 11376588
    Abstract: A method of identifying the presence of an analyte may include providing an in vitro test device and a test swab; obtaining a sample using the test swab; transitioning the locking member from the first configuration to the second configuration; advancing the plunger into the housing to pierce the one or more reagent pouches in the reagent region to cause reagent therein to be released and mix; inserting the test swab with obtained sample into the interior of the plunger; rotating the in vitro test device and disposing it on its plunger base; and determining whether the analyte is present. The in vitro test device may include a plunger, a housing, one or more reagent pouches disposed in the housing, a lateral flow test strip, and a locking member having configurations that either allow or prevent reagent in the one or more reagent pouches from being released.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: July 5, 2022
    Assignee: Checkable Medical Incorporated
    Inventor: Caleb Vainikka
  • Patent number: 11376597
    Abstract: A method of operating an electrowetting on dielectric (EWOD) device performs electrowetting operations on fluids dispensed into the EWOD device, which provides enhanced operation for using multiple non-polar filler fluids.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: July 5, 2022
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Lesley Anne Parry-Jones, Emma Jayne Walton
  • Patent number: 11358144
    Abstract: A micro-fluidic device is provided to sort out objects from a liquid stream. The device comprises a first channel comprising a first liquid and a second channel comprising a second liquid and the first liquid, and a third channel. The second channel is connected to the first channel and the channels are positioned such that a jet flow coming from the second channel can deflect objects in the first liquid into the third channel. The first liquid is a liquid which has a higher viscosity than water and the second liquid may be the same as or different from the first liquid. The micro-fluidic device is adapted for generating the jet flow in the second liquid.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 14, 2022
    Assignee: IMEC VZW
    Inventors: Chengxun Liu, Rodrigo Sergio Wiederkehr
  • Patent number: 11353471
    Abstract: A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 7, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rik Harbers, Marcel Thomann
  • Patent number: 11346852
    Abstract: This disclosure concerns a method and a system for quality evaluation of a handheld analytical device, wherein the device is operable by a human user in a sequence of handling steps to test an analyte in a sample fluid applied on a test element, the method comprising the steps of (a) programming a handling cycle for a robot having at least one robot arm in order to mimic the sequence of handling steps, (b) operating the device in at least one handling cycle by means of the robot, (c) monitoring the operation in step (b) by a control unit to evaluate at least one parameter influencing the quality of the device.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 31, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Wolfgang Schwoebel
  • Patent number: 11346814
    Abstract: A resonator is disclosed for the detection of a mass analyte, such as a biological analyte. The resonator has: a piezoelectric layer formed of a piezoelectric material; a first resonator region and a second resonator region each occupying a corresponding region of the piezoelectric layer; electrodes disposed to apply a driving signal to the piezoelectric layer to generate bulk acoustic waves, the electrodes being common to the first resonator region and the second resonator region. In operation, the first resonator region has a first resonant frequency and the second resonator region has a second resonant frequency. The first resonator region and the second resonator region differ from each other in that the first resonator region is adapted to receive a mass analyte for the mass analyte selectively to attach to a surface of the first resonator region.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 31, 2022
    Assignee: Cambridge Enterprise Limited
    Inventors: Andrew Flewitt, Ewelina Wajs, Girish Rughoobur
  • Patent number: 11331661
    Abstract: A fluid analysis cartridge having an improved structure in order to increase test reliability, and a fluid analysis apparatus including the same are disclosed.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 17, 2022
    Inventors: Kyu Youn Hwang, Young Seop Seong, Jong Myeon Park, Jeo Young Shim, Do Gyoon Kim, Jae Sung Lee, Hae Seok Lee
  • Patent number: 11324458
    Abstract: Provided are an electronic device and a method for controlling the same. An electronic device for providing continuous blood glucose monitoring comprises: a first sensor for measuring a glucose level of an interstitial fluid in order to predict blood glucose; a second sensor disposed on an inner surface of the electronic device to be in contact with a human body, in order to measure at least one of a blood flow and a heart rate of the human body; and a processor for determining a diffusion time during which glucose present in blood diffuses into the interstitial fluid, on the basis of characteristics of a signal generated by the second sensor, and predicting the blood glucose on the basis of the glucose level measured by the first sensor and the determined diffusion time.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 10, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hyoung-seon Choi, Young-jae Oh, Min-hyoung Lee, Seong-je Cho, Chul-ho Cho
  • Patent number: 11319585
    Abstract: A system may include a first conduit configured to form a first batch of discrete volumes of aqueous fluid separated by spacing liquid disposed between consecutive volumes of aqueous fluid, the spacing liquid being immiscible with the aqueous fluid volumes; a second conduit, fluidically coupled to the first conduit, the second conduit configured to statically hold the first batch of discrete volumes of aqueous fluid; and a third conduit configured to receive the first batch of discrete volumes of aqueous fluid from the second conduit. The third conduit can be configured to transfer the discrete volumes of aqueous fluid of the first batch for downstream processing.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: May 3, 2022
    Inventors: Willy K. Wiyatno, Linda Lee, David Cox, James Nurse, Douglas Greiner, Dennis Lehto, Janusz Wojtowicz, Sam Woo, Richard Reel
  • Patent number: 11318238
    Abstract: A blood inspection system automatically repeats blood inspections at a plurality of times at a desired interval and a desired timing by chronologically coupling a supply of blood to each one of a series of blood inspection units. A change in a blood condition, such as a clotting time, is monitored so that a thrombus or the like is prevented from being formed and an associated medicine is prevented from being overdosed. The blood inspection system has a catheter providing a main flow path, a supply of a flushing liquid, a plurality of inspection units, a plurality of branched flow paths, an aspiration unit, and a switching valve for selectively coupling the main flow path to a determined inspection unit which has not yet performed an inspection.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 3, 2022
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Takeshi Tsubouchi
  • Patent number: 11305289
    Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: April 19, 2022
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Katja Morgenroth, Vanessa Viertel, Ulf Steller, Stefan Gerlach, Christian Marzahl, Jörn Voigt, Winfried Stöcker
  • Patent number: 11308055
    Abstract: Disclosed herein are nucleic acid-based data storage systems and nucleic acid data storage constructs comprising reusable nucleic acid sequences, each representing information carried by a single bit (and, in some embodiments, one or more adjacent bits) within a bit string, and each furthermore representing the position of the single bit within the bit string. Also described are methods for storing data in the nucleic acid-based data storage systems and nucleic acid data storage constructs of the disclosure.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: April 19, 2022
    Inventors: Joseph Alan Walder, Jeffrey A. Manthey, William E. Martin, III, Shawn Allen
  • Patent number: 11293933
    Abstract: A fully-automatic feces analyzer includes an automatic controller; at least one sample box for containing a feces sample; and a sample box support. A dilution and stirring unit is provided for adding diluent into the feces sample and stirring to obtain feces sample liquid. The analyzer has a physical detection unit for performing a physical detection on the feces sample liquid and at least one chemical detection unit for performing a chemical detection on the feces sample liquid. Each chemical detection unit includes a driving roller and a driven roller, a reagent strip roll wound on the driven roller, an end portion of the reagent strip roll fixed on the driving roller.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 5, 2022
    Inventor: Xianglong Li
  • Patent number: 11290846
    Abstract: A method for managing a working environment of a worker who moves in a workplace includes: a measuring process in which a mobile device worn by the worker carries out environment measurement with use of a sensor; a location identifying process in which the mobile device identifies a location at which the measuring process has been carried out; and a transmitting process in which the mobile device transmits, to a management device, (i) a measurement value that has been obtained in the measuring process and (ii) positional information indicative of the location that has been identified in the location identifying process, in association each other.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 29, 2022
    Assignee: SINTOKOGIO, LTD.
    Inventors: Takashi Suzuki, Keisuke Takayanagi
  • Patent number: 11287422
    Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: March 29, 2022
    Inventors: Michael Previte, Molly Min He, Junhua Zhao, Hui Zhen Mah, Chunhong Zhou, Sinan Arslan, Matthew Kellinger, Lorenzo Berti, Steve Xiangling Chen
  • Patent number: 11281194
    Abstract: The system utilizes a laboratory data management system (LDMS), a medical data management system (MDMS) and external data sources. The system processes data across multiple laboratories, different input variables (lab assays), specific laboratory tests, specific laboratory testing capabilities and variable outputs. The system measures, documents and manages the immune response by providing the user with actionable laboratory results, triggers and events.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: March 22, 2022
    Inventor: Barry Fernando
  • Patent number: 11280739
    Abstract: A surface enhanced luminescence system may include a laser and a controller to output control signals causing the laser to irradiate the pre-analyte exposed plasmonic surface while maintaining a profile of the pre-analyte exposed plasmonic surface.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: March 22, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Raghuvir N. Sengupta, Anita Rogacs
  • Patent number: 11246676
    Abstract: A safety apparatus for use in a procedure comprises at least first and second devices, wherein the first device and second device are for use in a medical procedure, the apparatus comprising a disabling mechanism that is adapted to releasably retain and thereby prevent use of the said second device until release by a release procedure using the first device. A method of carrying out a procedure comprises the steps of using the first device, applying the first device to a disabling mechanism to release the second device, and using the second device.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: February 15, 2022
    Inventor: Peter Jeffrey Young
  • Patent number: 11225639
    Abstract: A cell sorting device is characterized by including: a main flow channel (14) through which a liquid containing a row of cells including a target cell flows, and in which a cell separation area for separating the target cell from the row of cells is provided at a halfway position in a flow direction, the main flow channel being formed in a substrate (12); a selection flow channel (16) into which the target cell is pushed out from the main flow channel, the selection flow channel being formed in the substrate so as to branch from the main flow channel downstream of the cell separation area; a sub flow channel (18) through which a separating liquid flows, the separating liquid being for separating the target cell from the row of cells and pushing out the target cell into the selection flow channel, the sub flow channel being formed in the substrate so as to intersect with the main flow channel in the cell separation area; a pair of liquid flow generating members (22) for generating a liquid flow of the separati
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: January 18, 2022
    Inventors: Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai
  • Patent number: 11226278
    Abstract: A microfluidic solenoid point of use device for discrete quantitation of magnetized cells. The inventive device provides higher accuracy, lower cost, and less bulk than other counting devices.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: January 18, 2022
    Assignee: Kennesaw State University Research and Service Foundation, Inc.
    Inventor: Hoseon Lee
  • Patent number: 11215547
    Abstract: The present invention provides a method for measuring gas permeability of a polymer membrane, for example, by evaluating polymer-structure influence on gas permeability in of a polymer membrane.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: January 4, 2022
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventors: Jin Hyeok Cha, Woong Pyo Hong, Suk Hwan Yun
  • Patent number: 11215627
    Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 4, 2022
    Inventors: Kenta Imai, Toshiharu Suzuki, Shigeki Matsubara, Takayuki Sugime, Shunsuke Sasaki, Elke Faatz, Beatus Ofenloch-Haehnle
  • Patent number: 11213228
    Abstract: A sensor assembly for analysis of physical parameters and chemical constituents of small volume samples of bodily fluids with at least two analyte sensors. The sensor assembly including a separation panel with an upper surface and a lower surface and upper and lower fluid channels disposed within the upper and lower surfaces respectively. The fluid channels extending substantially between the first and second ends and when in an operating mode bodily fluid is in fluid communication with both the upper and lower fluid channels. The sensor assembly including a potentiometric chip positioned atop and an amperometric chip positioned beneath the separation panel with at least one analyte sensor positioned above and beneath each of the fluid channels and when the sensor assembly is in an operating mode the fluid is in fluid communication with the analyte sensors. A bonding media is disposed beneath the amperometric chip.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: January 4, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Kenneth P. Galano
  • Patent number: 11185887
    Abstract: An H2S sensor includes at least one acoustic wave transducer and a film having a polymer matrix. The polymer matrix includes carboxylate functional groups and lead or zinc cations. The film may have a thickness of between a hundred nanometres and a 2 microns The H2S sensor optionally includes an antenna to remotely interrogate the H2S sensor.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: November 30, 2021
    Inventors: Jean-Michel Friedt, Frédéric Cherioux, Simon Lamare, François Gegot
  • Patent number: 11181502
    Abstract: While an insulating film having a near-field light generating element placed thereon is being irradiated with light in an electrolytic solution, or after the film that has been irradiated with light is disposed in the electrolytic solution, a first voltage is applied between the two electrodes installed in the electrolytic solution across the film, a second voltage is then applied between the two electrodes, and a value of a current that flows between the two electrodes due to the application of the second voltage is detected. This procedure is stopped when the current value reaches or exceeds a pre-set threshold value, whereby a hole is formed at a desired location in the thin-film.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: November 23, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Naoshi Itabashi, Sonoko Migitaka, Itaru Yanagi, Rena Akahori, Kenichi Takeda
  • Patent number: 11150267
    Abstract: A scanning probe microscope and method of operating the microscope uses a resonant material between a metallic probe tip and a surface of a sample with at least one material having a dielectric constant ?. When electromagnetic radiation from a light source is transmitted to an interface between the metallic probe tip and the sample, absorption of the electromagnetic radiation by the resonant sensor material that is dependent on the dielectric constant of the at least one material of the sample is detected.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: October 19, 2021
    Inventors: Thomas R. Albrecht, Derek Nowak, Junghoon Jahng, Sung I. Park, Eun Seong Lee
  • Patent number: 11137389
    Abstract: Methods are provided for correcting an analyte concentration measurement that may be influenced by hematocrit (HCT), especially a glucose concentration measurement. The methods include determining by means of a reference instrument a HCT reference value of a reference blood sample taken from a specific user, applying a fresh blood sample of the user on a disposable analytical test element, measuring the glucose value of the fresh blood sample by single use of the test element in a glucose meter, determining a HCT correction value using at least the HCT reference value, and adjusting the measured glucose value using the HCT correction value to receive an adjusted glucose value. Also provided are devices and system incorporating or for performing the methods.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 5, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Jochen Schulat, Sebastian Trick
  • Patent number: 11130120
    Abstract: A micro-droplet-emulsifier to generate a micro-droplet-emulsion for application on digital polymerase chain reaction is provided. This device includes a micropipette to hold a dispersed-phase-liquid; a droplet generator that attaches to the micro-pipette and has a plurality of substantially flat micro-channels. The dispersed-phase-liquid is forced through the micro-channels to form micro-droplet-emulsion of dispersed-liquid-phase in the continuous-liquid-phase inside the chamber. The size of the micro-droplets is controlled by the shape and the aspect ratio of the micro-channels, the depth of the micro-channels and the material of the micro-droplet-generator-head that dictates the contact angle of the droplet on the micro-channels.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: September 28, 2021
    Inventors: Lifeng Xiao, Yuan Min Wu, Yuanji Chen
  • Patent number: 11123736
    Abstract: Systems and methods for performing biological assays are provided herein. The systems and methods determine one or more characteristics of a nucleic acid amplification sample based on a modified optical property of the sample.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: September 21, 2021
    Assignee: Lucira Health, Inc.
    Inventors: Debkishore Mitra, Frank B. Myers, III, John Robert Waldeisen, Ivan Krastev Dimov
  • Patent number: 11110461
    Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: September 7, 2021
    Inventors: Eugene Tan, Heung Chuan Lam, Valery Leonidovich Bogdanov, Gregory John Kellogg, John A. Wright, Ulrich Hans Thomann, Richard F. Selden
  • Patent number: 11105774
    Abstract: A novel light-assisted quartz crystal microbalance and a measurement method thereof. The microbalance comprises a QCM/QCM-D chip, an oscillation circuit, a frequency counter, a computer, a reaction chamber, and a light source. Light emitted from the light source is able to irradiate a surface of the QCM/QCM-D chip. By additionally configuring a light source with the ability to irradiate a chip surface, when irradiated the surface of the QCM/QCM-D chip changes properties thereof, and irradiation of the surface of the QCM/QCM-D chip greatly increases the resonance frequency. Correspondingly, irradiation of the surface of the chip also changes mechanical properties and piezioelectric characteristics of quartz crystal, thereby effectively improving measurement sensitivity of a quartz crystal microbalance apparatus system.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: August 31, 2021
    Assignee: Jiangsu University
    Inventors: Jie Wang, Lei Liu
  • Patent number: 11098346
    Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: August 24, 2021
    Assignee: University of Washington
    Inventors: Joshua Bishop, Joshua Buser, Samantha Byrnes, Shivani Dharmaraja, Elain S. Fu, Jared Houghtaling, Peter C. Kauffman, Sujatha Kumar, Lisa Lafleur, Tinny Liang, Barry Lutz, Bhushan Toley, Maxwell Wheeler, Paul Yager, Xiaohong Zhang
  • Patent number: 11067523
    Abstract: A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed. The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: July 20, 2021
    Inventor: Yoshihito Hayashi
  • Patent number: 11060958
    Abstract: A sample preparation system includes a sample input, a first chamber fluidly coupled to the sample input and containing a sample preparation reagent, a second chamber containing a surface enhanced Raman spectroscopy (SERS) sensor structure and a third chamber containing a sensor preparation solution. The sample input, the first chamber and the second chamber are fluidly coupled to one another in a series and the third chamber is fluidly coupled to the third chamber outside of the series so as to sequentially direct a sample received by the sample input through the first chamber to the second chamber and out of the second chamber and so as to direct the sensor preparation solution into the second chamber following discharge of the sample out of the second chamber.
    Type: Grant
    Filed: February 27, 2016
    Date of Patent: July 13, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Anita Rogacs
  • Patent number: 11061013
    Abstract: This disclosure comprises devices and methods for determining the identity of individual protein molecules in a complex mixture by unfolding the protein into a polypeptide, tagging selected residues on the polypeptide with selected oligonucleotide sequence tags that recognize selected residues on said polypeptide, and then detecting the oligonucleotide sequence tags.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: July 13, 2021
    Inventor: Kalim Mir
  • Patent number: 11041870
    Abstract: An automated analysis device includes a reagent disc on which a plurality of reagent containers are loaded; a reagent loader that loads a reagent from the outside onto the reagent disc and carries a reagent to the outside; a display unit that displays the reagents in the plurality of reagent containers, so as to be paired with corresponding analysis items for which the reagents are used; and a control unit that causes the reagent loader to simultaneously carry, to the outside of the reagent disc, a reagent which is selected, on the display unit, by an operation device used for an operation input from an operator instructing the reagent loader to take out the reagent and simultaneously carry a reagent which is to be used for a different analysis item to be performed simultaneously with the analysis item for the selected reagent.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: June 22, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Satoshi Yokotsuka, Toshiharu Suzuki, Rira Okashita
  • Patent number: 11037912
    Abstract: A multi-color LED display comprises pixels, each comprising a first sub-pixel, a second sub-pixel, and a third sub-pixel. The first sub-pixel comprises a first light-emitting diode (LED) that emits a first color of light, the second sub-pixel comprises second LEDs that emit a second color of light different from the first color of light, and the third sub-pixel comprises third LEDs that emit a third color of light different from the first color of light and different from the second color of light. The second LEDs are electrically connected in parallel and the third LEDs are electrically connected in series.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: June 15, 2021
    Assignee: X Display Company Technology Limited
    Inventors: Matthew Alexander Meitl, Christopher Andrew Bower, Ronald S. Cok, Brook Raymond
  • Patent number: 11035497
    Abstract: Provided is a centrifugal valve control apparatus including: a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel; a heating part coupled to the body and including a heating member disposed at a position corresponding to the valve; and a rotation driving part configured to rotate the body part and the heating part together, wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together. Accordingly, the valve of the centrifugal valve control apparatus may be accurately controlled.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 15, 2021
    Inventor: Min Seok Kim
  • Patent number: 10969904
    Abstract: The present application discloses a noise detecting method and apparatus, and an electronic device, the method includes: obtaining a noise of each sensing electrode of a plurality of sensing electrodes of a touch screen at a current operating frequency point during an operation of the touch screen; calculating a difference between the noise of the sensing electrode and a current noise reference of the sensing electrode to obtain a noise difference of the sensing electrode; performing differential processing on the noise differences of the sensing electrode and a noise difference of an adjacent sensing electrode of the sensing electrode, to obtain a first processing result comprising a plurality of values, and comparing a maximum value of the first processing result with a preset first threshold; if the maximum value is greater than the threshold, determining that there is noise interference at the current operating frequency point.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: April 6, 2021
    Inventor: Haikuan Jiang
  • Patent number: 10930481
    Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 23, 2021
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Linfan Li, Xiaoyu Zhou
  • Patent number: 10921337
    Abstract: The purpose of the present invention is to provide an automatic analyzing device capable of carrying in/out a reagent suitable for the intended use of a user according to the state of the device. An automatic analyzing device has a reagent refrigerator for movably holding reagent containers and a reagent loader for carrying in/out the reagent containers to/from the reagent refrigerator through movement in a direction perpendicular to the reagent refrigerator. A reagent refrigerator cover covers an upper surface of the reagent refrigerator and has an opening through which the reagent loader can pass. A storage unit stores a device state of the automatic analyzing device and a reagent-carry-in/out-method is selected on the basis of the device state. A control unit controls the reagent holder and the reagent loader according to the selected reagent carry-in/out method so as to carry in/out a target reagent container.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: February 16, 2021
    Inventors: Hiroki Fujita, Toshiharu Suzuki, Takaaki Hagiwara
  • Patent number: 10871486
    Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 22, 2020
    Assignee: i-calQ, LLC
    Inventors: Joel R. L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
  • Patent number: 10870114
    Abstract: A microfluidic system includes: an electro-wetting on dielectric (EWOD) cartridge having an element array configured to receive liquid droplets, the element array including individual array elements each including array element circuity comprising sensing circuitry that is integrated into the array element circuitry; a microfluidic instrument that is configured to receive the EWOD cartridge and having an electrically conductive locator that is external to the EWOD cartridge; and a control system configured perform electrowetting operations by controlling actuation voltages applied to the element array to perform manipulation operations as to liquid droplets present on the element array. The control system further is configured to read an output from the sensing circuitry, determine a position of the locator relative to the element array based on the output, and determine a misalignment of the EWOD cartridge relative to the microfluidic instrument based on the position of the locator.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 22, 2020
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Benjamin James Hadwen, Oliver James Beard, Chris Clarke
  • Patent number: 10865436
    Abstract: A microfluidic apparatus, method, and associated applications utilize and apply to a formalin-fixed paraffin-embedded (FFPE) tissue sample and performing a liquid-liquid extraction to remove the paraffin from the tissue sample prior to a nucleic acid purification step. A microfluidic device includes a dedicated liquid-liquid extraction process vessel, a nucleic acid purification process component, and a nucleic acid amplification reactor. A liquid-liquid extraction and nucleic acid purification kit includes a microfluidic device capable of performing both a liquid-liquid extraction process and a nucleic acid purification process, including a dedicated liquid-liquid extraction process vessel, an immiscible liquid or a precursor phase thereof disposed in the vessel, a nucleic acid purification process component, a nucleic acid amplification reactor fluidically, and a supply of reagents suitable to enable the liquid-liquid extraction process and the nucleic acid purification process.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: December 15, 2020
    Assignee: RHEONIX, INC.
    Inventor: Peng Zhou