Means For Analyzing Liquid Or Solid Sample Patents (Class 422/68.1)
  • Patent number: 11662357
    Abstract: This automated analysis device is provided with a plurality of analysis units for analyzing a specimen, a buffer portion which holds a plurality of specimen racks on which are placed specimen containers holding the specimen, a sampler portion which conveys the specimen racks held in the buffer portion to the analysis units, and a control portion which, when performing a process to deliver the specimen racks to the plurality of analysis units, outputs synchronization signals to all the plurality of analysis units, wherein the analysis unit performs a delivery process starting from the synchronization signal, and the analysis unit performs a delivery process starting from the synchronization signal.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 30, 2023
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masashi Akutsu, Naoto Suzuki, Hiroki Fujita, Akihiro Yasui
  • Patent number: 11662345
    Abstract: A testing assembly for lateral flow assay comprising a liquid sample receiving unit arranged on a support structure defining a plane and configured to receive a liquid sample via the liquid sample receiving interface, at least one testing strip having, in a planar state, a testing strip center line length (L) in a longitudinal direction, a testing strip width in a width direction and a testing strip thickness, and comprising a capillary wick that includes a test portion that comprises a reacting material configured to react in a predetermined manner to a pre-specified analyte, wherein the width direction of the testing strip extends at an angle smaller than 90° with respect to a normal of the plane, and wherein the testing strip is curved, resulting in an effective extension being shorter than the testing strip center line length in the planar state.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: May 30, 2023
    Assignee: HOMEDICUS GMBH
    Inventors: Markus Riester, Michael Diebold, Jörn Bungartz
  • Patent number: 11634749
    Abstract: The present invention is based on the discovery of sensitive and specific methylation detection by a) controlling excessive DNA degradation prior to conversion by incubating DNA conversion reagent (e.g. bisulfite reagent) directly with a nucleic acid containing sample without requiring prior nucleic acid purification from the sample and without requiring prior nucleic acid denaturation at elevated temperatures of 98° C. and, b) optimizing bisulfite removal by controlling the pumping rate flow of the bisulfite treated sample over an extraction membrane inside an automated system. In some embodiments, a cartridge for the detection of methylated DNA is provided.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: April 25, 2023
    Assignee: BIOCARTIS NV
    Inventors: David Nauwelaers, Hannah Kenens
  • Patent number: 11624453
    Abstract: The embodiments disclosed herein relate to an apparatus for monitoring a valve having a control element, wherein the control element is actuated by an actuator, having: an adaptor between the control element and the actuator, wherein the adaptor couples a valve stem of the control element to the actuator; and an electronics module contained within the adaptor, wherein the electronics module further comprises one or more sensors.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 11, 2023
    Assignee: Bray International, Inc.
    Inventors: Craig Brown, Jim Schmidt, Brindesh Dhruva, Michael Kitchens, Stan Allen
  • Patent number: 11618020
    Abstract: The disclosure relates to an arrangement (100) in a capillary driven fluid system for metering a predetermined volume of sample fluid. The arrangement comprises a sample reservoir (SR) arranged to receive a sample fluid, a first channel (C1) which is in fluid communication with the sample reservoir (SR) and which branches off into a second channel (C2) ending at a first valve (V1) and a third channel (C3) ending at a second valve (V2). The second channel (C2) and the third channel (C3) together have a predetermined volume, and the first channel (C1) is arranged to draw sample fluid from the sample reservoir (SR) by use of capillary forces to fill the second channel (C2) and the third channel (C3) with the predetermined volume of sample fluid. By selectively opening the first valve (V1) and the second valve (V2), a capillary driven flow may be formed, thereby causing the predetermined volume of sample fluid to flow out through the first valve (V1).
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: April 4, 2023
    Assignee: miDiagnostics NV
    Inventor: Benjamin Jones
  • Patent number: 11614395
    Abstract: Nanofluidic flow cells and systems for single-molecule nanoconfinement and imaging of molecules in a fluid are described. The nanofluidic flow cell comprises a bottom substrate bonded to a top substrate, microchannels and a central chamber carved in the bottom or top substrate. The microchannels and the central chamber define an empty space into which a fluid can flow. The microchannels extend on opposite side of the central chamber, each microchannel comprising a central portion crossing the central chamber and a pair of arms extending outside the central chamber, these arms comprising a fluid port positioned at opposite ends of the microchannel and outside the central chamber. The central chamber comprises a nanoconfinement and imaging area including carved nanostructures configured for single-molecule nanoconfinement. Also described are nanofluidic chips, methods of confinement, pneumatic-based nanofluidic systems and manifold assembly for the nanofluidic flow cell.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: March 28, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Sabrina R. Leslie, Daniel J. Berard
  • Patent number: 11614609
    Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: March 28, 2023
    Assignee: S.D. Sight Diagnostics Ltd.
    Inventors: Noam Yorav-Raphael, Joseph Joel Pollak, Sarah Levy Schreier, Yochay Shlomo Eshel
  • Patent number: 11609413
    Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: March 21, 2023
    Assignee: S.D. Sight Diagnostics Ltd.
    Inventors: Noam Yorav-Raphael, Joseph Joel Pollak, Sarah Levy Schreier, Yochay Shlomo Eshel
  • Patent number: 11596332
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: March 7, 2023
    Assignee: Dexcom, Inc.
    Inventors: Mark C. Shults, Rathbun K. Rhodes, Stuart J. Updike, James H. Brauker
  • Patent number: 11598759
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples. More specifically, the present disclosure provides a sensor and/or array of sensors to measure metal and/or metalloid analytes, e.g., sensor and/or array of sensors having a chelator molecule, the chelator molecule including a peptide.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: March 7, 2023
    Assignee: Icagen, LLC
    Inventors: Benjamin P. Warner, Chang-Tai Hsieh, Emilia Solomon, Lori Peterson, Douglas Krafte, Nathan Zahler
  • Patent number: 11591566
    Abstract: This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: February 28, 2023
    Assignee: Inguran, LLC
    Inventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Blair Morad, Donald Francis Perrault, Jr.
  • Patent number: 11577243
    Abstract: The present invention relates to a sensor assembly (1) for body fluids.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: February 14, 2023
    Assignee: RADIOMETER MEDICAL APS
    Inventors: Christian Strange, Peter Frischauf
  • Patent number: 11573206
    Abstract: A combined vapor and/or gas concentration sensor and switch includes a resonating structure, a first alternating current, AC, voltage source coupled to a drive electrode, the first AC voltage source providing the resonating structure with a first voltage having an amplitude causing a first vibration mode of the resonating structure to exhibit a pull-in band and having a first frequency response adjacent to the pull-in band, where the first frequency response is nonlinear, a second AC voltage source coupled to the drive electrode and providing a second voltage having a frequency so that a second frequency response of the resonant structure, adjacent to a third vibration mode, is linear, and a read-out circuit coupled configured to determine a vapor and/or gas concentration based on a difference between (1) the frequency of the second voltage and (2) a frequency obtained by the read-out circuit from the resonating structure.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: February 7, 2023
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Nizar Jaber, Mohammad Ibrahim Younis
  • Patent number: 11573411
    Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: February 7, 2023
    Assignee: S.D. Sight Diagnostics Ltd.
    Inventors: Noam Yorav-Raphael, Joseph Joel Pollak, Sarah Levy Schreier, Yochay Shlomo Eshel
  • Patent number: 11565254
    Abstract: There is provided a sample processing cartridge comprising a. a sample entry location; b. a closed sample processing chamber; c. a sample analysis location comprising a sample analysis well; d. a first channel fluidly connecting the sample entry location and the sample processing chamber; e. a second channel connecting the sample analysis location and the sample processing chamber, the second channel comprising a closed or closable second channel valve; wherein the sample processing chamber comprises a second channel port providing fluid connection between the second channel and the sample processing chamber, the second channel port being positioned in a sample accumulating region of the sample processing chamber. There is also provided a sample processing system comprising the cartridge, and methods of use of the cartridge and processing system in a sample processing assay.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: January 31, 2023
    Assignee: GSG Technology LTD.
    Inventor: Graham Gutsell
  • Patent number: 11564668
    Abstract: A biopsy device includes a body, a needle, a hollow cutter, and a tissue sample holder. The needle extends distally from the body and includes a lateral aperture. The cutter is movable relative to the needle to sever a tissue sample and defines a cutter lumen. The tissue sample holder includes a manifold and an outer cover. The manifold includes a plurality of passages and an indexing portion. Each passage of the plurality of passages is configured to selectively index relative to a proximal end of the hollow cutter. The outer cover includes a resilient member. The resilient member is configured to engage with the indexing portion of the manifold to selectively index a passage of the plurality of passages with the distal end of the hollow cutter.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: January 31, 2023
    Assignee: Devicor Medical Products, Inc.
    Inventors: Edward A. Rhad, Morgan R. Hunter, Andrew P. Nock, Bryan R. Keller, Emmanuel V. Tanghal, Rachel Yoon Choung
  • Patent number: 11555801
    Abstract: An assembly is provided for interfacing with a microfluidic chip having at least one microscopic channel configured to receive a liquid sample for analysis. The assembly includes a chip carrier, an electronics module, an optical module, and a mechanical module. The chip carrier includes a base and a cover defining a cavity to receive the microfluidic chip. The electronics module includes a signal generator which applies at least one electrokinetic signal electrode(s) of the chip. The optical module includes an excitation radiation source which causes excitation radiation to impinge on the sample, and an emission radiation detector which detects radiation emitted from the sample. The mechanical module includes a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom.
    Type: Grant
    Filed: September 21, 2019
    Date of Patent: January 17, 2023
    Assignee: International Business Machines Corporation
    Inventors: Jaione T. Azpiroz, Emmanuel Delamarche, Claudius Feger, Ricardo L. Ohta, Mathias B. Steiner, Yuksel Temiz
  • Patent number: 11547996
    Abstract: A device enables a user to detect biomarkers, and includes an element that defines a multiplicity of microfluidic channels that communicate between an inlet duct and an outlet duct, the inlet duct communicating with an inlet port into which a user can introduce a drop of body fluid; the outlet duct communicating with an outlet port. A resilient bladder is connected to the outlet port to provide suction. Each microfluidic channel defines a reaction chamber containing a biomarker-sensitive reagent which provides a color or a change of color in the presence of a biomarker, there being a multiplicity of different biomarker-sensitive reagents, one such biomarker-sensitive reagent being provided in each of the multiplicity of different microfluidic channels. At least part of the element is transparent so the color within the reaction chamber can be seen. The device includes a cover with magnifying lenses above the reaction chambers. The device may be used in conjunction with a smart phone.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: January 10, 2023
    Assignee: VITAL SIGNS SOLUTIONS LIMITED
    Inventors: Kiran Roest, Vladimir Gubala
  • Patent number: 11536734
    Abstract: A method and particle analyzer for measuring a low concentration particles sample disclosed.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: December 27, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Wenheng Guo, Baohua Yan, Tao Shen
  • Patent number: 11525828
    Abstract: The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a blood plasma sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad disposed along a length of the base and is configured to hold the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The conjugate pad is further configured to receive the blood plasma sample. The test strip also includes a plurality of second and third antibodies that bind to ST2, and the conjugate-ST2 complexes, respectively. The plurality of second antibodies are bound to a membrane in a test location and the plurality of third antibodies are bound to the membrane in a control location.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 13, 2022
    Assignee: Critical Care Diagnostics, Inc.
    Inventors: James V. Snider, Jillian Elizabeth Bender, Shrin P. Kuo, Roy A. Chung
  • Patent number: 11513067
    Abstract: A sample carrier is provided for carrying a liquid sample to be measured by a spectrometer. The sample carrier includes a frame body and a mesh-like carrier body. The frame body has a notch located at the bottom of the frame body. The mesh-like carrier body is fixed to the frame body and located at the notch, the mesh-like carrier body has a plurality of apertures, and the liquid sample is retained in at least some of the apertures. Also provided is a spectrometer including the sample carrier. The sample carrier is capable of carrying the liquid sample and allows simple light path control.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: November 29, 2022
    Assignee: InnoSpectra Corporation
    Inventors: Fei-Peng Chang, Nan-Yu Chen, Hsi-Pin Li
  • Patent number: 11500359
    Abstract: The system utilizes a laboratory data management system (LDMS), a medical data management system (MDMS) and external data sources. The system processes data across multiple laboratories, different input variables (lab assays), specific laboratory tests, specific laboratory testing capabilities and variable outputs. The system measures, documents and manages the immune response by providing the user with actionable laboratory results, triggers and events.
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: November 15, 2022
    Assignee: ART RESEARCH AND TECHNOLOGY, L.L.C.
    Inventor: Barry Fernando
  • Patent number: 11498064
    Abstract: A photometric dispensing nozzle unit, a photometric dispensing apparatus, and a photometric dispensing method are for preventing an increase in apparatus scale and have a simple structure to be easily handled. A nozzle performs suction/discharge of gas through a distal end opening and can have a dispensing tip attached thereto. A light guide end portion is provided in the nozzle and can receive or irradiate light at a distal end of the nozzle. A dispensing cylinder has a cylinder having a cavity therein, a plunger that is slidable in the cavity, and a suction/discharge port that performs suction/discharge of gas. A suction/discharge flow path passes through the nozzle and communicates with the suction/discharge port and the distal end opening of the nozzle. A light guide path is optically connected to the light guide end portion through the nozzle but not through the dispensing cylinder.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: November 15, 2022
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Kazuhiro Nakamura, Yu Sugiyama
  • Patent number: 11486831
    Abstract: A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: November 1, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Ichiro Tono, Takeshi Yamauchi, Shoichi Kanayama
  • Patent number: 11480542
    Abstract: A particulate matter sensor includes a shield through which exhaust gases flow in a direction of flow from upstream to downstream. A sensing element with a positive electrode and a negative electrode separated from the positive electrode by an electrode gap is located within the shield. The positive electrode includes a plurality of positive electrode branches each having positive electrode extensions extending downstream and separated from each other by positive electrode slots. A positive electrode extension tip for each has a positive electrode extension tip width. The negative electrode includes negative electrode branches each having negative electrode extensions extending upstream which are each flanked on each side thereof by a plurality of negative electrode slots. A negative electrode extension tip for each has a negative electrode extension tip width. A sum of the positive electrode extension tip widths is greater than a sum of the negative electrode extension tip widths.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 25, 2022
    Assignee: Delphi Technologies IP Limited
    Inventors: Charles S. Nelson, Gopinath Penamalli
  • Patent number: 11471881
    Abstract: The disclosure describes methods and devices with which to process and analyze difficult chemical, biological, environmental samples including but not limited to those containing bulk solids or particulates. The disclosure includes a cartridge which contains a separation tube as well as one or more valves and cavities for receiving raw sample materials and for directing and containing various fluids or samples. The cartridge may contain a separation fluid or density medium of defined density, and structures which direct particulates toward defined regions of the cartridge. Embodiments can include a rotational device for rotating the cartridge at defined rotational rates for defined time intervals. Embodiments allowing multiple assays from a single sample are also disclosed. In some embodiments, this device is used for direct processing and chemical analysis of food, soil, blood, stool, motor oil, semen, and other samples of interest.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: October 18, 2022
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Ulrich Schaff, Christopher Tomkins-Tinch, Jason Sauers, Greg Sommer
  • Patent number: 11474019
    Abstract: A method and apparatus for determining a concentration of aerosol particles in a carrier gas. The method comprises providing an aerosol having aerosol particles in a carrier gas comprising at least one condensable component; introducing at least part of the aerosol into a chamber of a pressure-rated vessel, wherein the chamber is delimited by at least one wall adjoining the chamber and set to a temperature which is above a saturation temperature of the at least one condensable component; subsequently removing part of the aerosol from the chamber, as a result of which a decrease in pressure in the chamber occurs, as a result of which the at least one condensable component condenses at least partly on the aerosol particles; and determining a concentration of aerosol particles in the carrier gas during removal of the part of the aerosol from the chamber.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: October 18, 2022
    Assignee: KARLSRUHER INSTITUT FUR TECHNOLOGIE
    Inventors: Ottmar Moehler, Benjamin Murray, Michael Adams
  • Patent number: 11468973
    Abstract: The present invention provides a process and method for repurposing existing compounds by leveraging genomic, phenotypic and pharmacological data to cure disease. Applying advanced mathematical analytics using massively interconnected computing capabilities to identify target rich sets of existing compounds available for animal testing at the earliest stage in the process collapses cycle time of development, dramatically reducing costs. Target rich sets obtained through this invention produce compounds or compositions which each have a demonstrated ability to modulate disease or an associated phenotypic expression. By rendering the mechanism of action irrelevant, this invention collapses the time and cost to discovery of an efficacious drug from decades to days and from $Billions to $Millions.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: October 11, 2022
    Inventor: Richard Postrel
  • Patent number: 11454638
    Abstract: A sample rack transport apparatus for transporting a sample rack to a sample analyser, comprising: a bidirectional transmission track for bidirectionally transmitting a sample rack without passing through the sample analyser; a feed channel in parallel with the bidirectional transmission track, wherein the sample rack may be delivered from the bidirectional transmission track to the feed channel and to the sample analyser; an unloading cache region located between the bidirectional transmission track and the feed channel, the unloading cache region being used for storing the sample tack; and an unloading mechanism for delivering the sample rack in the feed channel to the unloading cache region for storage, or delivering the sample rack stored in the unloading cache region to the bidirectional transmission track. Also provided are a sample analysis device and a sample analysis system using the sample rack transport apparatus.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: September 27, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Junwei Zhang, Changyin Yan, Changxing Wang, Xuerong Li, Yunfei Wang
  • Patent number: 11446671
    Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: September 20, 2022
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
  • Patent number: 11420203
    Abstract: The invention provides a microfluidic system comprising a cartridge coupled to a motor and adapted to move a fluid sample to a plurality of locations on the cartridge. The cartridge comprises a chevron shaped or substantially V shaped reaction chamber having at least three zones, a first zone positioned near the apex of the V shaped reaction chamber to define a detection zone, a second zone positioned near a first end of the V shaped reaction chamber and a third zone positioned near a second end of the V shaped reaction chamber. The motor and a control module is configured to provide a combination of centrifugal force and gravitational force to move said fluid sample between at least three zones.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: August 23, 2022
    Inventors: David Doolan, Donal Cronin, Eoin O'Nuallain
  • Patent number: 11415551
    Abstract: Various embodiments of an apparatus for measuring binding kinetics of an interaction of an analyte material present in a fluid sample are disclosed. The apparatus includes a sensing resonator having at least one binding site for the analyte material; actuation circuitry adapted to drive the sensing resonator into an oscillating motion; measurement circuitry coupled to the sensing resonator and adapted to measure an output signal of the sensing resonator representing resonance characteristics of the oscillating motion of the sensing resonator; and a controller coupled to the actuation and measurement circuitry, wherein the controller is adapted to detect an individual binding event between the at least one binding site and a molecule of the analyte material.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: August 16, 2022
    Assignee: Qorvo Biotechnologies, LLC
    Inventor: James Webster
  • Patent number: 11408901
    Abstract: The present invention relates to a strip for measuring blood lipids. The strip for measuring blood lipids, of the present invention, presses, with an optimal pressure or to an optimal height, a contact surface of a protruding part of a measurement layer disposed between an upper cover and a lower substrate, so as to improve the uniform diffusion of a biological sample, thereby having an effect of increasing measurement result accuracy of the biological sample.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 9, 2022
    Assignee: GREEN CROSS MEDICAL SCIENCE
    Inventors: Kyung Hwan Hyun, Jung Hyun Lee, Gi Wook Kim
  • Patent number: 11391749
    Abstract: This disclosure provides a gene chip comprising a substrate and at least one positioning device fixed on an upper surface of the substrate, wherein the at least one positioning device is provided with a receiving cavity for receiving a bead, the receiving cavity being arranged on a surface of the at least one positioning device facing away from the substrate, and a cross-sectional area of the receiving cavity is gradually decreased in a direction toward the upper surface of the substrate. This disclosure further provides a gene detection device comprising the gene chip.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 19, 2022
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Song Yang, Ming Zhu, Shiyu Zhang, Jiahui Han, Zheng Fang, Ge Shi, Haijun Niu, Yujie Liu, Yuyao Wang
  • Patent number: 11391748
    Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: July 19, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
  • Patent number: 11386552
    Abstract: A specimen analysis system includes at least one processor to receive image information that represents a respective plurality of pixels of an image of each of a plurality of testing areas to indicate the presence or absence of a test subject compound; to determine for each testing area a number of pixels that indicates either the presence or the absence of the test subject compound, if the number of pixels indicating positive for each of a plurality of testing areas equals or exceeds a first minimum threshold value indicating that the testing area is positive for either the presence or absence of the test subject compound, totaling all testing areas indicating positive for either the presence or absence of the test subject compound, and if the total number of the testing areas indicating positive for either the presence or absence of the test subject compound equals or exceeds a second minimum threshold value indicating an overall positive test result for either the presence or absence of the test subject co
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 12, 2022
    Assignee: GENPRIME, INC.
    Inventors: Michael Arthur Russell, Jason Buck Somes, Darby Dawn McLean, Claire Elizabeth Norton
  • Patent number: 11376588
    Abstract: A method of identifying the presence of an analyte may include providing an in vitro test device and a test swab; obtaining a sample using the test swab; transitioning the locking member from the first configuration to the second configuration; advancing the plunger into the housing to pierce the one or more reagent pouches in the reagent region to cause reagent therein to be released and mix; inserting the test swab with obtained sample into the interior of the plunger; rotating the in vitro test device and disposing it on its plunger base; and determining whether the analyte is present. The in vitro test device may include a plunger, a housing, one or more reagent pouches disposed in the housing, a lateral flow test strip, and a locking member having configurations that either allow or prevent reagent in the one or more reagent pouches from being released.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: July 5, 2022
    Assignee: Checkable Medical Incorporated
    Inventor: Caleb Vainikka
  • Patent number: 11376597
    Abstract: A method of operating an electrowetting on dielectric (EWOD) device performs electrowetting operations on fluids dispensed into the EWOD device, which provides enhanced operation for using multiple non-polar filler fluids.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: July 5, 2022
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Lesley Anne Parry-Jones, Emma Jayne Walton
  • Patent number: 11378545
    Abstract: A semiconductor structure capable of real-time spatial sensing of nanoparticles within a nanofluid is provided. The structure includes an array of gate structures. An interlevel dielectric material surrounds the array of gate structures. A vertical inlet channel is located within a portion of the interlevel dielectric material and on one side of the array of gate structures. A vertical outlet channel is located within another portion of the interlevel dielectric material and on another side of the array of gate structures. A horizontal channel that functions as a back gate is in fluid communication with the vertical inlet and outlet channels, and is located beneath the array of gate structures. A back gate dielectric material portion lines exposed surfaces within the vertical inlet channel, the vertical outlet channel and the horizontal channel.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: July 5, 2022
    Assignee: International Business Machines Corporation
    Inventors: Kangguo Cheng, Ali Khakifirooz, Ghavam G. Shahidi, Davood Shahrjerdi
  • Patent number: 11358144
    Abstract: A micro-fluidic device is provided to sort out objects from a liquid stream. The device comprises a first channel comprising a first liquid and a second channel comprising a second liquid and the first liquid, and a third channel. The second channel is connected to the first channel and the channels are positioned such that a jet flow coming from the second channel can deflect objects in the first liquid into the third channel. The first liquid is a liquid which has a higher viscosity than water and the second liquid may be the same as or different from the first liquid. The micro-fluidic device is adapted for generating the jet flow in the second liquid.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 14, 2022
    Assignee: IMEC VZW
    Inventors: Chengxun Liu, Rodrigo Sergio Wiederkehr
  • Patent number: 11353471
    Abstract: A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 7, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rik Harbers, Marcel Thomann
  • Patent number: 11346814
    Abstract: A resonator is disclosed for the detection of a mass analyte, such as a biological analyte. The resonator has: a piezoelectric layer formed of a piezoelectric material; a first resonator region and a second resonator region each occupying a corresponding region of the piezoelectric layer; electrodes disposed to apply a driving signal to the piezoelectric layer to generate bulk acoustic waves, the electrodes being common to the first resonator region and the second resonator region. In operation, the first resonator region has a first resonant frequency and the second resonator region has a second resonant frequency. The first resonator region and the second resonator region differ from each other in that the first resonator region is adapted to receive a mass analyte for the mass analyte selectively to attach to a surface of the first resonator region.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 31, 2022
    Assignee: Cambridge Enterprise Limited
    Inventors: Andrew Flewitt, Ewelina Wajs, Girish Rughoobur
  • Patent number: 11346852
    Abstract: This disclosure concerns a method and a system for quality evaluation of a handheld analytical device, wherein the device is operable by a human user in a sequence of handling steps to test an analyte in a sample fluid applied on a test element, the method comprising the steps of (a) programming a handling cycle for a robot having at least one robot arm in order to mimic the sequence of handling steps, (b) operating the device in at least one handling cycle by means of the robot, (c) monitoring the operation in step (b) by a control unit to evaluate at least one parameter influencing the quality of the device.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 31, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Wolfgang Schwoebel
  • Patent number: 11331661
    Abstract: A fluid analysis cartridge having an improved structure in order to increase test reliability, and a fluid analysis apparatus including the same are disclosed.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 17, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Kyu Youn Hwang, Young Seop Seong, Jong Myeon Park, Jeo Young Shim, Do Gyoon Kim, Jae Sung Lee, Hae Seok Lee
  • Patent number: 11324458
    Abstract: Provided are an electronic device and a method for controlling the same. An electronic device for providing continuous blood glucose monitoring comprises: a first sensor for measuring a glucose level of an interstitial fluid in order to predict blood glucose; a second sensor disposed on an inner surface of the electronic device to be in contact with a human body, in order to measure at least one of a blood flow and a heart rate of the human body; and a processor for determining a diffusion time during which glucose present in blood diffuses into the interstitial fluid, on the basis of characteristics of a signal generated by the second sensor, and predicting the blood glucose on the basis of the glucose level measured by the first sensor and the determined diffusion time.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 10, 2022
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hyoung-seon Choi, Young-jae Oh, Min-hyoung Lee, Seong-je Cho, Chul-ho Cho
  • Patent number: 11318238
    Abstract: A blood inspection system automatically repeats blood inspections at a plurality of times at a desired interval and a desired timing by chronologically coupling a supply of blood to each one of a series of blood inspection units. A change in a blood condition, such as a clotting time, is monitored so that a thrombus or the like is prevented from being formed and an associated medicine is prevented from being overdosed. The blood inspection system has a catheter providing a main flow path, a supply of a flushing liquid, a plurality of inspection units, a plurality of branched flow paths, an aspiration unit, and a switching valve for selectively coupling the main flow path to a determined inspection unit which has not yet performed an inspection.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 3, 2022
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Takeshi Tsubouchi
  • Patent number: 11319585
    Abstract: A system may include a first conduit configured to form a first batch of discrete volumes of aqueous fluid separated by spacing liquid disposed between consecutive volumes of aqueous fluid, the spacing liquid being immiscible with the aqueous fluid volumes; a second conduit, fluidically coupled to the first conduit, the second conduit configured to statically hold the first batch of discrete volumes of aqueous fluid; and a third conduit configured to receive the first batch of discrete volumes of aqueous fluid from the second conduit. The third conduit can be configured to transfer the discrete volumes of aqueous fluid of the first batch for downstream processing.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: May 3, 2022
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Willy K. Wiyatno, Linda Lee, David Cox, James Nurse, Douglas Greiner, Dennis Lehto, Janusz Wojtowicz, Sam Woo, Richard Reel
  • Patent number: 11305289
    Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: April 19, 2022
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Katja Morgenroth, Vanessa Viertel, Ulf Steller, Stefan Gerlach, Christian Marzahl, Jörn Voigt, Winfried Stöcker
  • Patent number: 11308055
    Abstract: Disclosed herein are nucleic acid-based data storage systems and nucleic acid data storage constructs comprising reusable nucleic acid sequences, each representing information carried by a single bit (and, in some embodiments, one or more adjacent bits) within a bit string, and each furthermore representing the position of the single bit within the bit string. Also described are methods for storing data in the nucleic acid-based data storage systems and nucleic acid data storage constructs of the disclosure.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: April 19, 2022
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Joseph Alan Walder, Jeffrey A. Manthey, William E. Martin, III, Shawn Allen
  • Patent number: 11293933
    Abstract: A fully-automatic feces analyzer includes an automatic controller; at least one sample box for containing a feces sample; and a sample box support. A dilution and stirring unit is provided for adding diluent into the feces sample and stirring to obtain feces sample liquid. The analyzer has a physical detection unit for performing a physical detection on the feces sample liquid and at least one chemical detection unit for performing a chemical detection on the feces sample liquid. Each chemical detection unit includes a driving roller and a driven roller, a reagent strip roll wound on the driven roller, an end portion of the reagent strip roll fixed on the driving roller.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 5, 2022
    Inventor: Xianglong Li