Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

Abstract: Described systems and methods allow the detection and quantitation of a target analyte such as a toxin, drug, pesticide, etc. Some embodiments use a sensor comprising photo-sensitive cells, e.g., cells genetically modified to express an opsin. A light source such as an LED is used to optically stimulate the sensor cells, triggering changes in a measurable quantity such as the polarization of the cell membrane. Some embodiments use electrical impedance measurements to monitor the cell's recovery from the state induced by the optical stimulation. The recovery process is affected by the presence of certain bio-active compounds, which allows detection and quantitation of such compounds.

Abstract: System and method for measuring a gas concentration are provided. A ball sensor generates a collimated beam of a surface acoustic wave including fundamental wave of first frequency and harmonic wave of second frequency, which propagates through a orbital path on piezoelectric ball while passing through sensitive film to adsorb a target gas. Temperature control unit controls ball temperature of the ball sensor. Signal processing unit transmits a burst signal to sensor electrode of the ball sensor to excite the collimated beam, receives burst signals after the collimated beam has propagated a predetermined number of turns around the piezoelectric ball, and calculates the gas concentration and the ball temperature by first and second relative changes in delay times of the first and second frequencies, respectively, using waveform data of the burst signals.

Abstract: A sweat sensor device (200) with analytical assurance includes at least one sensor (220) for detecting a first analyte, and at least one calibration medium (270) containing at least the first analyte. When the first analyte in the at least one calibration medium (270) comes into contact with the at least one sensor (220), the calibration medium (270) provides a calibration of the at least one sensor (220). A sweat sensor device (200) may further include a carrier (240) having at least one aperture (220a) and a reservoir (254) for storing the at least one calibration medium (270). The at least one aperture (220a) provides fluidic access to the at least one sensor (220) from the reservoir (254).

Abstract: A micro-electrical-mechanical system (MEMS) assembly includes a stationary stage, a rigid stage, at least one flexure configured to slidably couple the stationary stage and the rigid stage, at least one flexible electrode coupled and essentially orthogonal to one of the stationary stage and the rigid stage, and at least one rigid electrode coupled and essentially orthogonal to the other of the stationary stage and the rigid stage.

Abstract: Chemical sensors include a functionalized electrode configured to change surface potential in the presence of an analyte. A piezoelectric element is connected to the functionalized electrode. A piezoresistive element is in contact with the piezoelectric element.

Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.

Abstract: A chemiluminescence analyzer includes a reactor to cause waste liquid discharged from a blood purification apparatus to react with a reagent solution, a photodetector to measure an intensity of chemiluminescence arising in the reactor, a first liquid conveyor to convey the waste liquid from a waste liquid passage of the blood purification apparatus to the reactor, and a second liquid conveyor to convey the reagent solution to the reactor. The chemiluminescence analyzer further includes a liquid mixture passage extending from the reactor to convey a liquid mixture including the waste liquid and the reagent solution after reaction, a joint to couple the liquid mixture passage to the waste liquid passage of the blood purification apparatus, and an electric interface for connection with an external device.

Abstract: The present invention relates to a conductor having a substrate and a conductive coating film laminated on the substrate, wherein, the surface resistance value of the conductive coating film is 5×1010?/? or less, the Ra1 of the conductive coating film is 0.7 nm or less, the Ra2 value of the conductive coating film scanning probe microscopies 0.35 nm or less, and the conductive coating film is formed with a conductive composition containing a conductive polymer (A). In addition, the present invention relates to a conductive composition which contains a conductive polymer (A) and a surfactant (B), wherein the surfactant (B) contains a specific water-soluble polymer (C), and the content of a compound (D1) with an octanol-water partition coefficient (Log Pow) of 4 or more in the conductive composition is 0.001 mass % or less, relative to the total mass of the conductive composition.

Abstract: A gas detecting device includes an actuating-and-sensing module, a driving controller, a data storage device and a data processor. The actuating-and-sensing module includes a first gas sensor, a second gas sensor and a gas transportation actuator. The driving controller controls the actuations and non-actuations of the first gas sensor, the second gas sensor and the gas transportation actuator. The first gas sensor measures the target gas and transmits first gas measured information to the data storage device. The second gas sensor measures the target gas and transmits second gas measured information to the data storage device. The data processor calculates concentrations of the gases in the target gas by comparing the information stored in a gas database, the first gas measured information and the second gas measured information.

Abstract: A water treatment system, particularly pre-filtration unit of the water treatment system, comprising at least one chlorine sensor device, includes a salt-water treatment device which is connected to the chlorine sensor device, an electrolysis cell being disposed in the associated line, and thereafter a pump and a release valve.

Abstract: Embodiments of the present invention are directed to a semiconductor device. A non-limiting example of the semiconductor device includes a semiconductor substrate. The semiconductor device also includes a plurality of metal nanopillars formed on the substrate. The semiconductor device also includes an amperometric sensor associated with one of the plurality of nanopillars, wherein the amperometric sensor is selective to an enzyme-active neurotransmitter. The semiconductor device also includes a resistivity sensor associated with a pair of nanopillars, wherein the resistivity sensor is selective to an analyte.

Abstract: A magnetic biosensor includes a fluidic channel, a magnetic sensor and an acoustic wave emitter. The disposition of the magnetic sensor corresponds to the fluidic channel. The acoustic wave emitter includes two wave generating units, and the fluidic channel is disposed between the two wave generating units.

Abstract: There is provided a measurement device including: a first electrode and a second electrode that are configured to form an energization path via a measurement object at a front side and measure an electrical conductivity of the measurement object; and a reference electrode and an ISFET that are configured to measure a pH value of the measurement object, wherein a standard electrode of the reference electrode is disposed at a rear side of the first electrode and the second electrode.

Abstract: Embodiments of the present invention are directed to a semiconductor device. A non-limiting example of the semiconductor device includes a semiconductor substrate. The semiconductor device also includes a plurality of metal nanopillars formed on the substrate. The semiconductor device also includes an amperometric sensor associated with one of the plurality of nanopillars, wherein the amperometric sensor is selective to an enzyme-active neurotransmitter. The semiconductor device also includes a resistivity sensor associated with a pair of nanopillars, wherein the resistivity sensor is selective to an analyte.

Abstract: A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation value, ?S, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.

Abstract: Sensor clip assemblies, sensor clips, analyte testing systems, and methods for making and using the same are disclosed. A sensor clip assembly is disclosed for storing and dispensing analyte testing sensors. The sensor clip assembly includes numerous test sensors arranged in a stack. Each test sensor is configured to assist in testing an analyte in a fluid sample. The sensor clip assembly also includes a skeletal frame with a top, a bottom, and numerous sides. The top, bottom and sides are interconnected to define an internal chamber within which is stored the stack of test sensors. At least one of the sides includes one or more elongated rails with structural gaps on opposing sides thereof. For some configurations, multiple sides of the skeletal frame comprise at least one or multiple elongated rails, each of which has structural gaps on opposing sides thereof and may be columnar in nature.

Abstract: Increasing efficiency of absorbers is provided herein. In some embodiments, a method of processing a substrate may include determining a quantity of a removal species in an effluent stream flowing from a semiconductor processing chamber, wherein determining comprises: detecting or predicting a quantity of the removal species upstream of a chamber abatement apparatus in the effluent stream flowing from the semiconductor processing chamber; and removing the removal species from the effluent stream with the chamber abatement apparatus if the determined quantity of the removal species exceeds a threshold value of the removal species.

Abstract: The present disclosure relates to a measurement arrangement including: a first process automation technology field device, wherein the first field device includes a first inductive interface and a data processing unit, and wherein a second process automation technology field device can be connected to the first interface; and a data transfer device having a second inductive interface that is designed to complement the first interface, wherein the data transfer device can be connected via this to the first field device, wherein the data transfer device includes a data transfer module with which digital data can be transferred from a source to the data processing unit of the first field device via the data transfer device and the first or second inductive interface. The present disclosure likewise relates to a method for temporarily transmitting digital data from a source to a field device.

Abstract: A method of identifying substances in a material handling work environment that analyzes sensor input from the environment with an image processor to extract features of the substance using optical flow and object recognition, and operates a vector modeler and a particle modeler to generate multiple predictions about particle movement within the substance based on existing data models for physical properties to generate multiple predictions of physical properties of the substance.

Abstract: A sensing system for obtaining a gradient of soil properties in real-time as a function of soil depth is disclosed herein. The sensing system includes a support structure coupled to an agricultural implement and which is rotatable about a rotational axis relative to a frame of the agricultural implement. A sensor is arranged on a surface of the support structure and configured to generate an output signal indicative of the measured soil property based on a sensed a capacitance change corresponding to a change in a dielectric property of a measured soil sample with which the sensor interacts. A measuring unit is coupled to the at least one sensor and processes the output signal generated by the at least one sensor to generate a gradient profile of the soil properties in real-time as a function of one or more depths for display on a user interface.

Abstract: A system and method for quantifying white blood cells in a blood sample is described. The system includes a sample medium for depositing the same blood. The sample medium is positioned between a first electrode and a second electrode. The system also includes an electrical analyzer for supping pulsing sweeping voltage across the electrodes through the sample medium. The electrical analyzer is also configured for measuring capacitance across the sample medium before and after adding a chemical analyte. The system also includes a general processor in electrical or wireless communication with the electrical analyzer configured for quantifying the white blood cells in the blood sample based on the generated capacitance-voltage profile. The method is described to operate the system and to quantify the white blood cells in a blood sample.

Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.

Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.

Abstract: An online monitoring method and system (10) is disclosed. The system comprises a process data connection device (20) for the acquisition of a first set of process data (30) coming from a process data source (40), an input system (50) for the creation of a process fingerprint (60), a storage device (70) for storing the created process fingerprint (60), a data processing device (80) for calculating the distance between the stored process fingerprint (60) and the new sets of process data (30), a management device (75) for managing which fingerprints need to be evaluated and a feedback device (77) which handles the actions that need to be performed based on detection such as displaying the distance (90) on an output device (100).

Abstract: Chemical sensors and methods of using and making the same include a functionalized electrode configured to change surface potential in the presence of an analyte. A piezoelectric element is connected to the functionalized electrode and is configured to change in volume in accordance with the surface potential of the functionalized electrode. A piezoresistive element is in contact with the piezoelectric element and is configured to change in resistance in accordance with the volume of the piezoelectric element.

Abstract: Provided herein is a cell-free assay device, sometimes comprising a lipid bilayer and an endopeptidase assay component, for characterizing a pore forming protein. In some embodiments provided herein is an apparatus comprising a pressure system for characterizing an interaction. Also, provided herein are methods for using a cell-free assay device to characterize a pore forming protein and/or a test substance.

Abstract: According to various embodiments, there is provided a micro-electromechanical resonator, including a substrate with a cavity therein; and a resonating structure suspended over the cavity, the resonating structure having a first end anchored to the substrate, wherein the resonating structure is configured to flex in a flexural mode along a width direction of the resonating structure, wherein the width direction is defined at least substantially perpendicular to a length direction of the resonating structure, wherein the length direction is defined from the first end to a second end of the resonating structure, wherein the second end opposes the first end.

Abstract: A method includes receiving multiplexed sensor data from a sensor array. The multiplexed sensor data includes first data from a first sensor of the sensor array and second data from a second sensor of the sensory array. The first data includes first frequency information of a first cantilevered element, the first cantilevered element including a coating material having an affinity for a compound and no diffusion barrier. The second data includes second frequency information of a second cantilevered element, the second cantilevered element including the coating material and a diffusion barrier. The diffusion barrier inhibits mass transfer to the second cantilevered element. The method also includes conditionally generating, based on an analysis of the first data and the second data, an output. The output is conditioned on the first frequency information and the second frequency information indicating more than a threshold amount of the compound present at the sensor array.

Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.

Abstract: A fluorinated photopolymer composition is disclosed having a branched copolymer provided in a fluorinated solvent. The copolymer includes a branching unit, a first repeating unit having a fluorine-containing group, and a second repeating unit having a solubility-altering reactive group. The branched fluorinated photopolymer composition is particularly suited for the fabrication of organic electronic and bioelectronic devices, or other devices having sensitive active organic materials.

Abstract: Micro magnetic trap comprising a holder and a sample cell on said holder (5); means for providing a controllable homogeneous magnetic field (3) surrounding the sample cell; a modified micro-cantilever comprising a cantilever (1) having dimensions in the micron range and at least three paramagnetic microbeads with a diameter from 1 to 3 microns (2) attached to a bendable tip of the micro-cantilever such that they form a triangular arrangement; means for measuring the deflection of the micro-cantilever when the latter is in use (4). The trap does not require a specific surface functionalization in order to ensure an appropriate and selective linkage to a particular molecule.

Abstract: In one embodiment, a solar cell having internal storage capacity includes a working electrode, a counter electrode, an electrolyte provided between the electrodes, and a composite layer of material applied to an inner side of the working electrode, the layer comprising a photosensitive dye and a conducting polymer, wherein the conducting polymer is capable of storing energy generated within the cell.

Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.

Abstract: Provided are a neurovascular unit (NVU)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The NVU-on-a-chip includes an extracellular matrix (ECM) simulation material (70) in a gel state; and at least one channel (75) which passes through the ECM simulation material (70) and perfuses a culture medium, in which the ECM simulation material (70) contains a plurality of types of human brain cells on an outer side of the channel (75), a brain microvessel endothelial cell lining (91) is formed on an inner side of the channel (75), and the plurality of types of human brain cells and the brain microvessel endothelial cell lining (91) contact each other through the channel (75) to simulate a blood brain barrier (BBB) of a human brain and a neurovascular unit (NVU) of the human brain including the BBB.

Abstract: A method and device for multiplexing and calibrating rapid quantification of biomolecules present in a nanofluidic biosensor composed by a nanoslit. A novel concept defining multiple different local structured areas containing biomarkers. Local structured areas can also be structured to decrease the biomarkers density in the nanoslit. Such enables the multiplexed quantification biomolecular interactions of interest in the same nanofluidic biosensor.

Abstract: Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations.

Abstract: Methods and systems are provided for sensing particulate matter in an exhaust system of a vehicle. An example system comprises a particulate matter sensor inside a tube configured to receive a portion of exhaust gas in an exhaust passage.

Abstract: Methods to estimate safety and/or efficacy of therapeutic drugs, which include portable devices for anti-drug antibody (ADA) testing and databases containing anonymized data from humans and/or animal models, and related analyses, are provided. These methods and compositions can be used in various applications, including but not restricted to the following: uniform testing of patients for ADA; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering and/or developing therapeutic drugs; postmarketing surveillance of therapeutic drugs.

Abstract: A method for identifying sample boundaries of a plurality of samples is provided. The method includes moving a plurality of samples comprising particles into a fluid flow stream using a sampling probe and introducing marker beads into the fluid flow stream between adjacent samples in the plurality of samples via the sampling probe to produce a marker bead-separated plurality of samples in the fluid flow stream. Marker beads may be introduced into the fluid flow stream by introducing the marker beads from a chamber surrounding at least a portion of the sampling probe, or by introducing the marker beads from a cartridge having a pierceable membrane underlying at least one chamber, the at least one chamber containing marker beads. Sampling systems and apparatuses are also provided.

Abstract: Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.

Abstract: A bearing arrangement having a bearing mounted in a housing, wherein a grease lubricant is present within the housing for lubricating the bearing, a support frame at least partly made of an electrically insulating material, arranged in a space within the housing that lies axially between the bearing and a housing seal. The support frame includes at least one electrode pair having first and second electrodes arranged to enable grease lubricant to contact therewith. A capacitance meter provided for measuring a capacitance between the first and second electrodes. The support frame provides a radially oriented surface and a plurality of ribs that extend in a radially inward direction, the ribs having sufficient circumferential spacing to enable grease to flow between adjacent ribs. One of the first and second electrodes is provided on the radially oriented surface of the support frame or on a rib surface that faces an adjacent rib.

Abstract: A photoacoustic probe and photoacoustic device implementing the photoacoustic probe may reduce an artifact caused by an ultrasonic wave generated in the photoacoustic probe without mounting a separate device. The photoacoustic probe and photoacoustic device implementing the photoacoustic probe may reduce an artifact by changing a configuration or a structure provided in the photoacoustic probe. The photoacoustic probe may receive a photoacoustic signal generated from an inner material of an object absorbing light of a predetermined wavelength and may include a piezoelectric module to convert the photoacoustic signal into an electric signal, and an object contact unit disposed on the front surface of the piezoelectric module, the object contact unit contacting the object and not absorbing the light of a predetermined wavelength.

Abstract: A bearing arrangement is provided having a bearing mounted in a housing, wherein a grease lubricant is present within the housing for lubricating the bearing. The arrangement further provides a support frame made of an electrically insulating material, arranged in a space within the housing between the bearing and a housing seal. The support frame is provided with at least one electrode pair having first and second electrodes arranged such that a portion of the grease lubricant is located between the first and second electrodes. A capacitance meter is provided for measuring a capacitance between the first and second electrodes. The first and second electrodes of the at least one electrode pair are provided on a radially oriented surface of the support frame, which surface is arranged such that the grease is able to move in an axial direction over the surface.

Abstract: There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterize a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample.

Abstract: The present disclosure relates to a test strip handling device (100) that includes a housing (110) having an interior compartment (112) in which the test strips are received and stored. The device (100) facilitates sanitary handling and disposal of the test strips.

Abstract: An ISFET detector for determining concentration of a target ion in a fluid, the apparatus comprising: a semiconducting substrate comprising a source and a drain having source and drain electrodes respectively and a channel region between them in the substrate; an insulating material overlying the channel region; a gate electrode formed on the insulating material; a reference electrode electrifiable to establish an electric field in the channel region; an accumulator comprising a layer of material of thickness less than or equal to about 2 nm (nanometers) that accumulates a quantity of target ions responsive to concentration of the target ions in the fluid; a layer of a conducting material on which the accumulator is formed that is separate from the gate electrode; and a conducting element that electrically connects the layer of conducting material to the gate electrode.

Abstract: This application describes a radiation detector apparatus comprising: at least one optical fiber (104) suitable for distributed fiber optic acoustic/vibration sensing adjacent at least a first electrode (201) spaced apart from a second electrode (202) with a gas between the first and second electrodes.

Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.

Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.