Measuring Electrical Property Patents (Class 422/82.01)
  • Patent number: 10436772
    Abstract: A system and method for quantifying white blood cells in a blood sample is described. The system includes a sample medium for depositing the same blood. The sample medium is positioned between a first electrode and a second electrode. The system also includes an electrical analyzer for supping pulsing sweeping voltage across the electrodes through the sample medium. The electrical analyzer is also configured for measuring capacitance across the sample medium before and after adding a chemical analyte. The system also includes a general processor in electrical or wireless communication with the electrical analyzer configured for quantifying the white blood cells in the blood sample based on the generated capacitance-voltage profile. The method is described to operate the system and to quantify the white blood cells in a blood sample.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: October 8, 2019
    Inventors: Mahmoud F. Y. Al Ahmad, Shamsa Abdulla Saeed Ali AlHassani, Nouf Ali Salem Mohammed AlNeyadi, Meera Rashed Salem Obaid AlTamimi
  • Patent number: 10393690
    Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 27, 2019
    Assignee: The Research Foundation of State University of New York
    Inventors: Chuan-Jian Zhong, Jin Luo, Lingyan Wang
  • Patent number: 10369200
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: August 6, 2019
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Patent number: 10360249
    Abstract: An online monitoring method and system (10) is disclosed. The system comprises a process data connection device (20) for the acquisition of a first set of process data (30) coming from a process data source (40), an input system (50) for the creation of a process fingerprint (60), a storage device (70) for storing the created process fingerprint (60), a data processing device (80) for calculating the distance between the stored process fingerprint (60) and the new sets of process data (30), a management device (75) for managing which fingerprints need to be evaluated and a feedback device (77) which handles the actions that need to be performed based on detection such as displaying the distance (90) on an output device (100).
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 23, 2019
    Assignee: Trendminder N.V.
    Inventors: Thomas Dhollander, Bert Baeck, Stijn Meganck
  • Patent number: 10352888
    Abstract: Chemical sensors and methods of using and making the same include a functionalized electrode configured to change surface potential in the presence of an analyte. A piezoelectric element is connected to the functionalized electrode and is configured to change in volume in accordance with the surface potential of the functionalized electrode. A piezoresistive element is in contact with the piezoelectric element and is configured to change in resistance in accordance with the volume of the piezoelectric element.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: July 16, 2019
    Inventors: Qing Cao, Jianshi Tang, Ning Li, Ying He
  • Patent number: 10338070
    Abstract: Provided herein is a cell-free assay device, sometimes comprising a lipid bilayer and an endopeptidase assay component, for characterizing a pore forming protein. In some embodiments provided herein is an apparatus comprising a pressure system for characterizing an interaction. Also, provided herein are methods for using a cell-free assay device to characterize a pore forming protein and/or a test substance.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: July 2, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Eric Ervin, Anna E. P. Schibel
  • Patent number: 10211805
    Abstract: According to various embodiments, there is provided a micro-electromechanical resonator, including a substrate with a cavity therein; and a resonating structure suspended over the cavity, the resonating structure having a first end anchored to the substrate, wherein the resonating structure is configured to flex in a flexural mode along a width direction of the resonating structure, wherein the width direction is defined at least substantially perpendicular to a length direction of the resonating structure, wherein the length direction is defined from the first end to a second end of the resonating structure, wherein the second end opposes the first end.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: February 19, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Jinghui Xu, Nan Wang, Yuandong Alex Gu
  • Patent number: 10161847
    Abstract: A method includes receiving multiplexed sensor data from a sensor array. The multiplexed sensor data includes first data from a first sensor of the sensor array and second data from a second sensor of the sensory array. The first data includes first frequency information of a first cantilevered element, the first cantilevered element including a coating material having an affinity for a compound and no diffusion barrier. The second data includes second frequency information of a second cantilevered element, the second cantilevered element including the coating material and a diffusion barrier. The diffusion barrier inhibits mass transfer to the second cantilevered element. The method also includes conditionally generating, based on an analysis of the first data and the second data, an output. The output is conditioned on the first frequency information and the second frequency information indicating more than a threshold amount of the compound present at the sensor array.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: December 25, 2018
    Inventor: Robert Raymond Miller, II
  • Patent number: 10137480
    Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: November 27, 2018
    Inventors: James A. Ball, Phil Waggoner, Scott Parker
  • Patent number: 10078262
    Abstract: A fluorinated photopolymer composition is disclosed having a branched copolymer provided in a fluorinated solvent. The copolymer includes a branching unit, a first repeating unit having a fluorine-containing group, and a second repeating unit having a solubility-altering reactive group. The branched fluorinated photopolymer composition is particularly suited for the fabrication of organic electronic and bioelectronic devices, or other devices having sensitive active organic materials.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: September 18, 2018
    Assignee: Orthogonal, Inc.
    Inventors: Douglas Robert Robello, Charles Warren Wright, Diane Carol Freeman, Frank Xavier Byrne, John Andrew DeFranco, Sandra Rubsam, Terrence Robert O'Toole
  • Patent number: 10073057
    Abstract: Micro magnetic trap comprising a holder and a sample cell on said holder (5); means for providing a controllable homogeneous magnetic field (3) surrounding the sample cell; a modified micro-cantilever comprising a cantilever (1) having dimensions in the micron range and at least three paramagnetic microbeads with a diameter from 1 to 3 microns (2) attached to a bendable tip of the micro-cantilever such that they form a triangular arrangement; means for measuring the deflection of the micro-cantilever when the latter is in use (4). The trap does not require a specific surface functionalization in order to ensure an appropriate and selective linkage to a particular molecule.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: September 11, 2018
    Assignee: Universidad de Santiago de Chile
    Inventors: Francisco Esteban Melo Hurtado, Romina Waleska Muñoz Buzeta, Felipe Andrés Aguilar Sandoval
  • Patent number: 10069459
    Abstract: In one embodiment, a solar cell having internal storage capacity includes a working electrode, a counter electrode, an electrolyte provided between the electrodes, and a composite layer of material applied to an inner side of the working electrode, the layer comprising a photosensitive dye and a conducting polymer, wherein the conducting polymer is capable of storing energy generated within the cell.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: September 4, 2018
    Assignee: University of South Florida
    Inventor: Arash Takshi
  • Patent number: 10041906
    Abstract: Integrated electrophoresis and electroblotting systems and methods are provided. In one embodiment, a cassette includes a separation gel and a sheet adjacent to a surface of the separation gel, wherein the sheet is configured to be removed from the cassette without opening the cassette. Systems and methods are also described and illustrated.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: August 7, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Boaz Ran
  • Patent number: 10030219
    Abstract: Provided are a neurovascular unit (NVU)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The NVU-on-a-chip includes an extracellular matrix (ECM) simulation material (70) in a gel state; and at least one channel (75) which passes through the ECM simulation material (70) and perfuses a culture medium, in which the ECM simulation material (70) contains a plurality of types of human brain cells on an outer side of the channel (75), a brain microvessel endothelial cell lining (91) is formed on an inner side of the channel (75), and the plurality of types of human brain cells and the brain microvessel endothelial cell lining (91) contact each other through the channel (75) to simulate a blood brain barrier (BBB) of a human brain and a neurovascular unit (NVU) of the human brain including the BBB.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: July 24, 2018
    Inventors: Sang-Hoon Cha, Hong-Jun Lee, Nakwon Choi, Hong-Nam Kim
  • Patent number: 9989526
    Abstract: A method and device for multiplexing and calibrating rapid quantification of biomolecules present in a nanofluidic biosensor composed by a nanoslit. A novel concept defining multiple different local structured areas containing biomarkers. Local structured areas can also be structured to decrease the biomarkers density in the nanoslit. Such enables the multiplexed quantification biomolecular interactions of interest in the same nanofluidic biosensor.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: June 5, 2018
    Assignee: ABIONIC SA
    Inventors: Nicolas Durand, Iwan Märki, Annick Mayor, Stéphane Broillet
  • Patent number: 9958410
    Abstract: Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 1, 2018
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Huan-Ping Wu
  • Patent number: 9932878
    Abstract: Methods and systems are provided for sensing particulate matter in an exhaust system of a vehicle. An example system comprises a particulate matter sensor inside a tube configured to receive a portion of exhaust gas in an exhaust passage.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: April 3, 2018
    Assignee: Ford Global Technologies, LLC
    Inventor: Xiaogang Zhang
  • Patent number: 9927443
    Abstract: Methods to estimate safety and/or efficacy of therapeutic drugs, which include portable devices for anti-drug antibody (ADA) testing and databases containing anonymized data from humans and/or animal models, and related analyses, are provided. These methods and compositions can be used in various applications, including but not restricted to the following: uniform testing of patients for ADA; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering and/or developing therapeutic drugs; postmarketing surveillance of therapeutic drugs.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: March 27, 2018
    Assignee: ConquerAb Inc.
    Inventor: Maria D. F. S. Barbosa
  • Patent number: 9897531
    Abstract: A method for identifying sample boundaries of a plurality of samples is provided. The method includes moving a plurality of samples comprising particles into a fluid flow stream using a sampling probe and introducing marker beads into the fluid flow stream between adjacent samples in the plurality of samples via the sampling probe to produce a marker bead-separated plurality of samples in the fluid flow stream. Marker beads may be introduced into the fluid flow stream by introducing the marker beads from a chamber surrounding at least a portion of the sampling probe, or by introducing the marker beads from a cartridge having a pierceable membrane underlying at least one chamber, the at least one chamber containing marker beads. Sampling systems and apparatuses are also provided.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 20, 2018
    Assignee: Intellicyt
    Inventors: Constantine I. Andreev, Matthew Hess, Joe Zock
  • Patent number: 9835634
    Abstract: Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: December 5, 2017
    Assignees: The Board of Trustees of the University of Illinois, Purdue Research Foundation
    Inventors: Rashid Bashir, Bobby Reddy, Muhammad A Alam, Pradeep R Nair, Jonghyun Go
  • Patent number: 9644684
    Abstract: A bearing arrangement having a bearing mounted in a housing, wherein a grease lubricant is present within the housing for lubricating the bearing, a support frame at least partly made of an electrically insulating material, arranged in a space within the housing that lies axially between the bearing and a housing seal. The support frame includes at least one electrode pair having first and second electrodes arranged to enable grease lubricant to contact therewith. A capacitance meter provided for measuring a capacitance between the first and second electrodes. The support frame provides a radially oriented surface and a plurality of ribs that extend in a radially inward direction, the ribs having sufficient circumferential spacing to enable grease to flow between adjacent ribs. One of the first and second electrodes is provided on the radially oriented surface of the support frame or on a rib surface that faces an adjacent rib.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: May 9, 2017
    Inventors: Jeroen Bongaerts, Florin Tatar
  • Patent number: 9631971
    Abstract: A photoacoustic probe and photoacoustic device implementing the photoacoustic probe may reduce an artifact caused by an ultrasonic wave generated in the photoacoustic probe without mounting a separate device. The photoacoustic probe and photoacoustic device implementing the photoacoustic probe may reduce an artifact by changing a configuration or a structure provided in the photoacoustic probe. The photoacoustic probe may receive a photoacoustic signal generated from an inner material of an object absorbing light of a predetermined wavelength and may include a piezoelectric module to convert the photoacoustic signal into an electric signal, and an object contact unit disposed on the front surface of the piezoelectric module, the object contact unit contacting the object and not absorbing the light of a predetermined wavelength.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: April 25, 2017
    Inventors: Jung Taek Oh, Jung Ho Kim, Jong Kyu Jung
  • Patent number: 9556913
    Abstract: A bearing arrangement is provided having a bearing mounted in a housing, wherein a grease lubricant is present within the housing for lubricating the bearing. The arrangement further provides a support frame made of an electrically insulating material, arranged in a space within the housing between the bearing and a housing seal. The support frame is provided with at least one electrode pair having first and second electrodes arranged such that a portion of the grease lubricant is located between the first and second electrodes. A capacitance meter is provided for measuring a capacitance between the first and second electrodes. The first and second electrodes of the at least one electrode pair are provided on a radially oriented surface of the support frame, which surface is arranged such that the grease is able to move in an axial direction over the surface.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: January 31, 2017
    Inventors: Jeroen Bongaerts, Florin Tatar
  • Patent number: 9551702
    Abstract: There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterize a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: January 24, 2017
    Inventors: Vladislav Djakov, Richard Dunn
  • Patent number: 9546997
    Abstract: The present disclosure relates to a test strip handling device (100) that includes a housing (110) having an interior compartment (112) in which the test strips are received and stored. The device (100) facilitates sanitary handling and disposal of the test strips.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 17, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Robert S. Sams, Eugene Prais, Simin Yao
  • Patent number: 9518953
    Abstract: An ISFET detector for determining concentration of a target ion in a fluid, the apparatus comprising: a semiconducting substrate comprising a source and a drain having source and drain electrodes respectively and a channel region between them in the substrate; an insulating material overlying the channel region; a gate electrode formed on the insulating material; a reference electrode electrifiable to establish an electric field in the channel region; an accumulator comprising a layer of material of thickness less than or equal to about 2 nm (nanometers) that accumulates a quantity of target ions responsive to concentration of the target ions in the fluid; a layer of a conducting material on which the accumulator is formed that is separate from the gate electrode; and a conducting element that electrically connects the layer of conducting material to the gate electrode.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: December 13, 2016
    Inventors: Yael Nemirovsky, Lior Gal, Igor Brouk
  • Patent number: 9507030
    Abstract: This application describes a radiation detector apparatus comprising: at least one optical fiber (104) suitable for distributed fiber optic acoustic/vibration sensing adjacent at least a first electrode (201) spaced apart from a second electrode (202) with a gas between the first and second electrodes.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 29, 2016
    Inventor: Alastair Godfrey
  • Patent number: 9482602
    Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: November 1, 2016
    Inventor: Norberto A. Guzman
  • Patent number: 9459202
    Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 4, 2016
    Assignee: Zyomed Corp.
    Inventors: Sandeep Gulati, Timothy L. Ruchti, William Van Antwerp, John L. Smith
  • Patent number: 9314195
    Abstract: Methods, devices, and systems are provided that include an analyte sensor interface electronics for receiving a plurality of analyte related signals from an analyte sensor over a measurement time period, and a data processing component operatively coupled to the analyte sensor interface electronics for processing the received plurality of analyte related signals, the data processing component including a signal filtering component to filter the received plurality of analyte related signals, and a signal conversion component operatively coupled to the signal filtering component to convert the received filtered plurality of analyte related signals to determine an analyte level associated with a monitored analyte level during the measurement time period.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: April 19, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Martin J. Fennell
  • Patent number: 9285331
    Abstract: A device, method and system for measuring analytes in a solution or suspension. The device includes a housing, a sample chamber, one or more pumps, one or more detectors, one or more stirrers, electrical contacts, a magnetic manipulator and a lid. A sample cartridge for a device that measures analytes, the cartridge comprising a first outer compartment, a second outer compartment, and a middle compartment, wherein the first outer compartment and the second outer compartment are interconnected to the middle compartment by channels.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: March 15, 2016
    Inventors: Shelley Minteer, Vojtech Svoboda
  • Patent number: 9254485
    Abstract: An integrated semiconductor device for manipulating and processing bio-entity samples is disclosed. The device includes a microfluidic channel formed between a first substrate and a second substrate and a microfluidic grid formed over the first substrate and coupled to the microfluidic channel to manipulate a droplet within the microfluidic channel. The device further includes a magnetic field generation device included in the microfluidic grid and fluidic control circuitry coupled to the magnetic device to facilitate control of the magnetic field generation device to manipulate the droplet, when the droplet contains at least one magnetic bead, within the microfluidic channel.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: February 9, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yi-Hsien Chang, Chu-Ren Cheng
  • Patent number: 9212389
    Abstract: A method of detecting hybridization of complementary segments of nucleic acids by heat generated upon the aforementioned hybridization; a method of detecting the presence of a predetermined reactant in a sample suspected of containing the same, and an apparatus for detecting hybridization of complementary segments of nucleic acids by a heat generated upon aforementioned hybridization, that implements a pyroelectric thermal sensor or a bolometric thermal sensor or a quantum well thermal sensor.
    Type: Grant
    Filed: December 16, 2007
    Date of Patent: December 15, 2015
    Inventor: Amots Osri
  • Patent number: 9204829
    Abstract: A test meter for analyzing a body fluid sample applied to a test strip includes an outer housing having an opening, an actuator, and a cartridge positioned adjacent the outer housing. The cartridge further includes a dispensing member connected to the actuator, a plurality of stacked test strips biased toward the dispensing member, and a cartridge outer housing that is adjacent at least a portion of the dispensing member. Each time the actuator is actuated, the dispensing member is rotated to cause movement of one test strip from the plurality of stacked test strips through the opening, and another test strip is biased toward the dispensing member.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: December 8, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Eugene Prais, Michael A. Botta, Narasinha Parasnis, Serban Peteu, John Creaven, Simin Yao
  • Patent number: 9164076
    Abstract: A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: October 20, 2015
    Inventors: Dijia Huang, Huan-Ping Wu
  • Patent number: 9162259
    Abstract: A device for the regeneration of a biosensor having an immobilized and biologically active material applied to the surface of a carrier that is suitable for interacting with a substance to be analyzed. The device comprises at least one injector through which, by means of a pump, at least one solution can be applied to the surface of the carrier for the purposes of rinsing the biologically active material.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: October 20, 2015
    Assignee: EADS Deutschland GmbH
    Inventors: Ulrich Reidt, Alois Friedberger, Barbara Baur, Martin Eickhoff, Tom Lueders, Gerhard Mueller
  • Patent number: 9157974
    Abstract: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: October 13, 2015
    Assignee: T2 BIOSYSTEMS, INC.
    Inventors: Sonia Taktak, Brian M. Mozeleski, Thomas J. Lowery, Jr.
  • Patent number: 9146221
    Abstract: The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 29, 2015
    Assignee: Aviva Biosciences Corporation
    Inventors: Antonio Guia, George Walker, Jia Xu, Julian Yuan, Lei Wu, Mingxian Huang
  • Patent number: 9134305
    Abstract: An apparatus for detecting the presence of a target molecule is disclosed which includes a conductive nanostructure, a non-conductive polymer coating on at least a portion of the nanostructure, and a cavity formed in the polymer coating having a shape corresponding to the shape of the target molecule. A property of the nanostructure depends on the presence of the target molecule at the cavity.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: September 15, 2015
    Assignee: The Trustees of Boston College
    Inventors: Dong Cai, Thomas C. Chiles
  • Patent number: 9114398
    Abstract: A method and device for digital multiplex PCR assays employ a microfluidic chip for performing real-time, continuous flow PCR within microchannels of the chip. A stream of sample material is introduced into each microchannel and alternating boluses of assay-specific reagents and buffer are introduced into the stream to form sequentially configured test boluses. A PCR procedure is performed on the test boluses followed by a thermal melt procedure. During the thermal melt procedure, fluorescent output is detected and fluorescence vs temperature data is collected and compared to expected normal correlations. The results, positive or negative, are converted to digital format, with positive results designated as “1” and negative results designated as “0”, or vice versa.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: August 25, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Ivor T. Knight, Hiroshi Inoue
  • Patent number: 9057719
    Abstract: A method of fabricating a material having nanoscale pores is provided. In one embodiment, the method of fabricating a material having nanoscale pores may include providing a single crystal semiconductor. The single crystal semiconductor layer is then patterned to provide an array of exposed portions of the single crystal semiconductor layer having a width that is equal to the minimum lithographic dimension. The array of exposed portion of the single crystal semiconductor layer is then etched using an etch chemistry having a selectivity for a first crystal plane to a second crystal plane of 100% or greater. The etch process forms single or an array of trapezoid shaped pores, each of the trapezoid shaped pores having a base that with a second width that is less than the minimum lithographic dimension.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: June 16, 2015
    Inventors: Chengwen Pei, Zhengwen Li
  • Patent number: 9039974
    Abstract: A biological sample measuring device including a mounting portion to which a biological sample measuring sensor is mounted, a voltage application section that applies voltage to a counter electrode of the biological sample measuring sensor mounted to the mounting portion, amplifiers that are selectively connected to a working electrode of the biological sample measuring sensor, and a determination section that is connected to these amplifiers. The determination section has a threshold determination section that determines a voltage value obtained by voltage conversion of the current value of the working electrode, a same determination section that selectively connects the amplifiers to the working electrode depending on the determination of the threshold determination section, and identifies the sample deposited on the biological sample measuring sensor from the output of the selected amplifier, and an output section that outputs a measurement value corresponding to the identified sample.
    Type: Grant
    Filed: January 16, 2012
    Date of Patent: May 26, 2015
    Inventors: Shouko Hironaka, Teppei Shinno, Eriko Yoshioka, Takashi Miki
  • Patent number: 9039877
    Abstract: The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 26, 2015
    Inventors: Ying-Che Huang, Lan-Hsiang Huang, Ching-Yuan Chu
  • Patent number: 9041419
    Abstract: Examples of the present invention include apparatus and methods for monitoring aging of an item. A solid-state structure is located within, adjacent to, or otherwise proximate the item, the solid-state structure including nanostructures. The electrical resistance and/or magnetization of the solid-state structure is determined to determine the degree of aging of the item. In representative examples, the solid-state structure includes nanostructures of a metal, such as a ferromagnetic metal, within a non-magnetic matrix, such as a semimetal, semiconductor, or insulator.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: May 26, 2015
    Assignee: Indiana University of Pennsylvania
    Inventor: Gregory G. Kenning
  • Patent number: 9034263
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: May 19, 2015
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Patent number: 9034262
    Abstract: A molecularly imprinted polymer (MIP) sensor including a substrate, two or more electrodes, a conductive layer applied to the substrate and a molecularly imprinted polymer layer applied to the conductive layer is disclosed herein The MIP sensor may form part of an MIP sensor system that can be used to detect and quantify target molecules.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: May 19, 2015
    Assignee: The Trustees of Dartmouth College
    Inventors: Joseph J. Belbruno, Ursula J. Gibson, Jane E. G. Lipson, Martin N. Wybourne
  • Patent number: 9034264
    Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 19, 2015
    Assignee: Highland Biosciences Limited
    Inventor: Richard Day
  • Patent number: 9028777
    Abstract: Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: May 12, 2015
    Assignee: Fluidigm Corporation
    Inventors: Kyle W. Hukari, Jason A. A. West, Michael A. Shultz, Richard Milson, Nikolas M. Isely, Michael C. DeRenzi
  • Patent number: 9029132
    Abstract: A sensor for biomolecules includes a silicon fin comprising undoped silicon; a source region adjacent to the silicon fin, the source region comprising heavily doped silicon; a drain region adjacent to the silicon fin, the drain region comprising heavily doped silicon of a doping type that is the same doping type as that of the source region; and a layer of a gate dielectric covering an exterior portion of the silicon fin between the source region and the drain region, the gate dielectric comprising a plurality of antibodies, the plurality of antibodies configured to bind with the biomolecules, such that a drain current flowing between the source region and the drain region varies when the biomolecules bind with the antibodies.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: May 12, 2015
    Assignee: International Business Machines Corporation
    Inventors: Marwan H. Khater, Tak H. Ning, Lidija Sekaric, Sufi Zafar
  • Patent number: 9023281
    Abstract: Chemical indicator apparatuses containing one or more chemical indicators for use in monitoring the quality of water in an aquatic environment. The apparatuses are designed and configured to be submersible in the water that is being monitored. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo a physical change as levels of one or more constituents of the water change. Such indicators can be read by one or more suitable optical readers. These and other embodiments are designed and configured to be movable by a corresponding monitoring/measuring apparatus, for example, via a magnetically coupled drive. Also disclosed are a variety of features that can be used to provide a chemical indicator apparatus with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 5, 2015
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark