Abstract: Apparatus or systems which employ luminescence-quenching to produce a signal indicative of oxygen concentration.

Abstract: A system for the detection of nitric oxide in a gas sample includes a converter for oxidation of nitric oxide to nitrogen dioxide, a nitrogen dioxide sensor including nanostructures and a filtering device to remove at least carbon dioxide from the gas sample positioned upstream of the converter. The nitrogen dioxide sensor can, for example, include a recognition layer on the nanostructures adapted to enhance sensitivity to nitrogen dioxide. A method for detecting nitric oxide in exhaled breath includes detecting nitric oxide in the exhaled breath using a nitric oxide sensor including nanostructures. Another method for detecting nitric oxide in exhaled breath includes filtering the breath to remove at least carbon dioxide from the breath, oxidizing nitric oxide in the exhaled breath to nitrogen dioxide and detecting the nitrogen dioxide using a nitrogen dioxide sensor including nanostructures.

Abstract: The present invention includes a method and apparatus for monitoring drug compliance by detecting markers, such as odors, upon exhalation by a patient after medication is taken, wherein such markers result either directly from the medication itself or from an additive combined with the medication. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial noses” or “electronic noses,” to non-invasively monitor compliance. The invention further includes a reporting system capable of tracking compliance (remote or proximate) and providing the necessary alerts.

Abstract: There is provided herein a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both), the polymer substance includes: a porous support member having a plurality of pores, wherein at least a portion of the pores are filled with a cross-linked co-polymer comprising (i) a cationic monomer and an anionic monomer, (ii) a zwitterionic monomer, or a combination thereof. The substance may include a membrane or a tube.

Abstract: There is provided herein a dryer polymer substance comprising a polymer grafted with a compound having sulfonic groups, wherein the substance is adapted to pervaporate a fluid such as water, water vapor or both. There is further provided a process for the preparation of a dryer polymer substance adapted to pervaporate a fluid, the process includes processing a polymer into a desired form, activating at least a portion of the polymer, and grafting the activated portion of the polymer with a compound having groups adapted to be sulfonated.

Abstract: Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels.

Abstract: Disclosed is a method for measuring pancreatic metabolism, which is characterized by the fact that the increase in 13CO2 in the exhaled breath is determined prior to and following the intravenous application of secretin as well as prior to and following the oral application of a 13C triglyceride.

Abstract: As previous processing of measurement in which gas to be measured containing, as gas components, carbon dioxide 13CO2 and carbon dioxide 12CO2, is introduced into a cell, and in which the intensities of transmitted lights having wavelengths suitable for measurement of the respective gas components, are measured and then data-processed to measure the concentrations of the gas components, the air having a predetermined volume Va is sucked by a gas injection device 21, a gas exhaust valve V6 of a cell 11 is closed and the air stored in the gas injection device 21 is transferred to the cell 11 filled with the air at an atmospheric pressure, thereby to pressurize the cell inside. The pressure thus pressurized is measured as P. The cell volume Vc is subtracted from the product obtained by multiplying the sum.

Abstract: A breath tester housing assembly is provided. The assembly comprises a housing having a base to be gripped by an operator, a display oriented to be in line with an operator's direct line of view while gripping the base, and a mouthpiece interface for interfacing with a removable mouthpiece so that when a subject blows into the mouthpiece, the display is not in the direct line of view of the subject. The assembly further comprises a mouthpiece for engaging to the mouthpiece interface. The mouthpiece comprises a body having a substantially planar surface.

Abstract: Methods, computer program products, and systems are described that include detecting in an exhalant at least one indication of bioactive agent use by an individual and altering at least one artificial sensory experience at least partly based on the at least one indication of bioactive agent use by an individual.

Abstract: A chemical vapor sensor is provided that passively measures a suspect chemical species of interest with high sensitivity and chemical specificity, for use with safety systems. A vapor concentrator amplifies a suspect chemical vapor concentration to a detectible level, for use with an infrared detector. Compensation is provided for environmental variations that may influence the passive measurement of the chemical vapor sensor. Environmental variations may include extrinsic vapors in the surrounding air, or air currents that divert the sample vapor as it drifts from the suspect vapor source to a sampling intake. In an example, ethanol vapor is measured and carbon dioxide tracer measurements are used to calculate an ethanol vapor measurement that is adjusted for environmental variations. In an aspect, a time artifact filter sets the output of the carbon dioxide sensor to match the time dependence of the ethanol sensor, to calculate blood alcohol concentration.

Abstract: A volumetric flow of an analyte, including exhaled air, is fed to a gas sensor unit by used of gas flow device, which can include various sensors for the determination of nitrogen oxides. An oxidation catalyst is used when using an NO2 sensor, which converts nitrogen monoxide to nitrogen dioxide and the gas sensor unit measures the content of nitrogen dioxide. The nitrogen monoxide content is calculated from the nitrogen dioxide content. In order to eliminate cross-sensitivity moisture and ethanol are also measured. The device can be applied to the determination of nitrogen monoxide content of exhaled air.

Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.

Abstract: Methods and systems using one or more expert systems to screen equipment operators for impairments, such as chemical impairment, physical impairment, medical impairment, or emotional impairment, to selectively test the equipment operators and rescue the equipment operator and control the equipment (e.g., automobiles, trucks, industrial vehicles, public transportation vehicles, such as buses, subways, trains, planes, ships, watercraft, sport vehicles, and dangerous or potentially dangerous machinery in general) if impairment of the equipment operator is determined. One embodiment is a method to screen and rescue an equipment operator having a chemical impairment, using one or more expert systems. A second embodiment is a method to screen and rescue an equipment operator having an impairment, such as chemical impairment, physical impairment, medical impairment, or emotional impairment, using one or more expert systems.

Abstract: This invention generally relates to a screening method for identifying compositions suitable for use in an oral composition (e.g., a confection or chewing gum product) effective for the treatment of oral cavity malodor associated with the consumption of garlic. In particular, this invention relates to a screening method for determining the ability of a composition to reduce the concentration of a sulfide or disulfide compound (e.g., diallyl disulfide) present in a model sample or solution which is representative of the oral cavity of a subject after consuming garlic, as an indicator of the effectiveness of that composition in the treatment of oral cavity malodor associated with the consumption of garlic.

Abstract: A breathalyzer test device includes vigilance detecting means for detecting the vigilance of a test subject, and breathalyzer test means for performing a breathalyzer test on the subject based on the vigilance detected by the vigilance detecting means.

Abstract: The present invention in several embodiments is a cell phone with breath analyzer that can store a preprogrammed list of phone numbers that are not to be called once a person's blood alcohol level has reached a specific point. This device could look similar to traditional cell phones. Within the mouth piece, or other place on or in the phone is a blood alcohol detector. As a person talks/breaths into the phone, their blood alcohol level will be measured. If the level is over a predetermined amount, a previously programmed list of phone numbers cannot be accessed. This unit may also have the capability to store a help list for the user. This list would allow the consumer to easily call a specific list of individuals if they were in need of a ride or other forms of assistance.

Abstract: The invention relates to methods of identification or evaluation of compounds useful in the field of fragrances and aromas (the volatile part of a flavor). Methods according to the invention take into account the occurrence of enzymatic metabolism in the human respiratory tract, including the oral and in particular the nasal cavity.

Abstract: A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.

Abstract: A breath alcohol-measuring device for breathing gas sampling has a mouthpiece (2), for receiving the exhaled breathing air (1) of a test subject, provided with a first flow diaphragm (3). A first pressure sensor (6) is connected to the mouthpiece via a first gas line upstream of the flow diaphragm (3). An alcohol sensor (4) is connected to the mouthpiece (2) via an inlet channel downstream of the flow diaphragm (3) and to a sampling system (5) for a breathing gas sample from the breathing air (1) via a second gas line. The second gas line between the alcohol sensor (4) and the sampling system (5) has a second flow restriction (diaphragm 7) and is connected to a second pressure sensor (9). An evaluating and control unit (8) receives the measured signals of the pressure sensors (6, 9) and of the alcohol sensor (4) and actuates the sampling system (5).

Abstract: Some embodiments of the invention provide a mouthpiece for use with an electronic analyzer for breath analyte detection in an individual. The mouthpiece includes a biosensor and a hydration system. The biosensor includes a chemically active area where a chemical reaction takes place and the hydration system delivers a liquid to the chemically active area of the biosensor to at least one of enhance, enable, and facilitate the chemical reaction. The mouthpiece further includes hardware to transmit breath analyte data.

Abstract: An apparatus and non-invasive method of measuring oxygen by exciting a luminescent compound disposed in a container and then measuring the intensity of the light emitted by the excited luminescent compound as it relaxes to the ground state. A plot of emission intensity as a function of time results in an exponential decay curve the area of which is inversely proportional to the oxygen concentration. The oxygen concentration can be determined over a wide temperature range by measuring the temperature of the container and the emission intensity and then applying the following equation: [O2]=(ATa(T)2+BTa(T)+CTa)(tau)2+(ATb(T)2+BTb(T)+CTb)(tau)+(ATc(T)2+BTc(T)+CTc) T is the measured temperature; tau is the area of the exponential decay curve; and ATa, BTa, CTa, ATb, BTb, CTb, ATc, BTc, and CTc are coefficients that are specific to the luminescent compound being examined.

Abstract: The subject invention is directed to a breath analyzer which is capable of detecting toxic gas levels from breath analysis. The subject invention includes a mouthpiece which is in communication with a plurality of discrete chambers, such as first and second discrete chambers, each being provided with a separate probe for breath analysis. The probes are connected to analyzers for determining detected levels of gas. In a first embodiment, a first probe may be provided for carbon monoxide detection with a second probe being provided for hydrogen cyanide detection. Advantageously, with this arrangement, breath analysis may be conducted on-site, for example at the site of a fire, to quickly and simultaneously determine carbon monoxide and hydrogen cyanide levels in a person's blood stream. In a second embodiment, a first probe may be provided for detection of carbon monoxide and a second probe may be provided for detection of hydrogen.

Abstract: A process is provided for distinguishing between wet from dry gas with a breath alcohol measuring device, in which a defined sample volume from a gas blown in is fed for sampling to an electrochemical sensor (6), which generates a sensor signal that depends on the reaction of ethyl alcohol. The sensor signal is sent to a control and evaluating unit (4) and is evaluated there to determine the alcohol concentration. To distinguish dry gas from wet gas, provisions are made for the sensor signal to be detected in its time dependence and for the presence of wet gas to be determined when it is observed that a sensor signal of a polarity opposite the polarity of the sensor signal caused by the reaction of ethyl alcohol appeared at first at the beginning of sampling. The process may be used, e.g., in conjunction with the calibration of breath alcohol measuring devices or in so-called interlock systems with a breath alcohol measuring device in order to recognize attempts at manipulation.

Abstract: The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Abstract: A method and apparatus for of assessing the blood concentration level in a human or animal subject, of a volatile blood constituent (preferably alcohol) is disclosed. The method comprises steps of positioning a sensor (21, 22) within the expiratory gas flow of the subject, wherein the sensor (21, 22) is configured to detect the presence of the constituent and provide a first output signal representative of the concentration of said constituent in air, and also to detect a presence of carbon dioxide and to provide a second output signal representative of the concentration of carbon dioxide in air. The flow of expiratory gases from the subject is sampled to provide a first signal and second signal in respect of the expiratory gases substantially simultaneously.

Abstract: A method may include providing an output comprising a presentation format to an end user. The output may be provided for user-based interaction. An interactive response from the end user may be measured in response to the presentation format of the output, where the interactive response may be indicative of at least one physiological condition regarding the end user.

Abstract: A multifunctional earphone includes an earphone body, and an alcohol-testing module provided in the earphone body. The alcohol-testing module includes an alcohol-testing unit provided with an alcohol concentration-measuring program to measure an alcohol concentration of a user of the multifunctional earphone to obtain a measured alcohol concentration value; and a communication unit to receive the measured alcohol concentration value from the alcohol-testing unit, and analyze the measured alcohol concentration value.

Abstract: A breath simulator for supplying a breath test analyzer with a sample effluent of ethyl alcohol that controls headspace and adjacent effluent passageway temperature.

Abstract: A total amount of volatile organic compounds (VOCs) in a breath sample (101) is detected by oxidizing/burning (120) the VOCs to form CO2 and H2O, and the amounts of one or both of these compounds are measured (130). CO2 and H2O molecules in the breath sample (101) are removed (110) before the VOCs are converted (120) to CO2 and H2O. Because one VOC molecule contains multiple carbon and hydrogen atoms, the number of formed CO2 and H2O molecules will be substantially larger than the original number of VOC molecules, thereby improving the sensitivity of the detection.

Abstract: An alcohol density test can be avoided, but the alcohol density test is prevented from being easily avoided at the same time. A vehicle control unit sets a controlled vehicle in a mobile state when an alcohol density detected from the driver is determined to be lower than a predetermined threshold based on results of a test conducted using an alcohol test unit or when an instruction for exemption of the alcohol test is input through an input unit. When an instruction for exemption of the alcohol test is input, a history recording control unit records a history indicating that the alcohol density test has been exempted in a recording unit. The invention may be applied to a vehicle control apparatus for controlling a vehicle based on results of an alcohol density test conducted on the driver.

Abstract: A method of analyzing alveolar breath. Breath is expired through an analysis chamber. The concentration of a first component of the breath is monitored as the breath is expired through the analysis chamber. When the concentration of the first component indicates that alveolar breath is in the analysis chamber, at least one concentration measurement of a second component of the breath is triggered. Concentration measurements of the second component are discontinued when the concentration of the first component indicates that alveolar breath is no longer passing through the analysis chamber.

Abstract: The present invention relates to a method and an apparatus for measuring Functional Residual Capacity (CO). Further, it relates to a method and an apparatus for measuring cardiac output (CO). The method comprises the steps of determining the amount of oxygen and carbon dioxide being inhaled and exhaled during at least two breathing cycles, identifying at least one difference between said breathing cycles, and estimating the FRC and/or CO based on the determined uptake of oxygen and excretion of carbon dioxide and said identified difference.

Abstract: A sensor main unit 1 is axially split into three sub-segments. A light-emitting element 2 is attached to one end portion, and a light-receiving element 3 is attached to the other end portion. A respiratory flow path 4 is formed so as to penetrate through the center portion. The sensor main unit 1 is attached to a position on the face below the nostrils, and respiratory gas from the nostrils is guided into the respiratory flow path 4 and is caused to cross over the optical axis connected the light-emitting element 2 and the light-receiving element 3, thereby measuring a carbon dioxide gas in the respiratory gas.

Abstract: An interlock system for measuring the sobriety of a potential motorized apparatus operator is coupled to the starting mechanism of said motorized apparatus. The interlock system includes a microprocessor controlled handset, base unit and photographic device. The photographic device facilitates the identification process of the person taking the test by taking at least two consecutive pictures, one before and one during the test, which makes circumvention of the test a recordable event for later viewing by a monitoring person or facility. Further, rolling re-tests are used in the event the motorized apparatus was allowed to engage and operate and to once again verify the blood alcohol content of the person operating said apparatus and verify their identity during said test with said photographic device.

Abstract: A breath alcohol detection device includes a one-piece multi-passage block with attached sensors, a valve and a fuel cell. The cell accurately determines the BrAC of a prospective vehicle operator. In the event the BrAC is less than the legal maximum for a territory, the device unlocks an ignition interlock to permit starting of the engine and operation of the vehicle.

Abstract: A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evaluation fuel cell in which the fuel cell sample electrode is contacted with the sample with the analysis based on a function of standard time response curves for an equivalent fuel cell configuration obtained separately for each of the analytes on a fuel cell with equivalent construction as sample-evaluation fuel cell. Each of the plurality of analytes is generally indicative of an aspect of the individual's health. Suitable analytes include, for example, inorganic compounds as well as compositions that exhibit negative reduction reactions at least for a portion of the time response curve.

Abstract: A breath simulator for supplying a breath test analyzer with a sample effluent of ethyl alcohol that controls headspace and adjacent effluent passageway temperature.

Abstract: The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.

Abstract: Device and method for non-invasively monitoring asthma and other respiratory diseases, as well as non-respiratory diseases. The method includes collecting condensate from a subject's breath, testing the condensate to determine its acetic acid/acetate level or concentration, and evaluating these properties to determine the presence, absence or status of a respiratory or non-respiratory disease in the subject. The method may also include, prior to the testing step, standardizing the volatile substances that may be present within the condensate in a degassing or gas standardizing step. The device includes a mouthpiece apparatus configured to receive breath from a subject, a condensation apparatus to condense the subject's breath and produce a condensate, and a collection apparatus having a collection chamber containing means for testing the condensate to determine the acetic acid and/or acetate concentration.

Abstract: A RF breathalyzer system, which transmits a unique RF signal in response to a toxic or non-toxic breath sample given to a RF breathalyzer by the user. An immobilizer CPU is installed in a vehicle to receive commands from the RF breathalyzer and to control a horn and lights of a vehicle, to immobilize the engine, and is connected to a GPS antenna driver through a mobile phone/pager unit to communicate with a monitoring station.

Abstract: A sidestream sampling system includes a sidestream gas measurement assembly and a sample cell configured to be assembled therewith. The sidestream gas measurement assembly includes a receptacle for removably receiving at least a portion of the sample cell. The sample cell is coupled to a sampling tube that is configured to communicate with an airway of an individual. When the sample cell is assembled with the sidestream gas measurement assembly, a window of the sample cell is oriented toward a corresponding source and/or detector of the sidestream gas measurement assembly to facilitate monitoring of an amount of at least one gas or vaporized material in an individual's respiration.

Abstract: A method of assessing the state of the lining of the small intestine in a mammal or human injesting a suitable labelled test substrate which requires conversion by a brush border enzyme for transport across the small intestinal lining. Suitable substrates include sucrose and maltose. The transport of these can very conveniently be measured by assessing the amount of label present in carbon dioxide expelled in the breath after a period of time. It has been shown that this method has application to assessing damage cause by chemotherapeutic induced mucositis as well as gastroenteritis with an infectious cause.

Abstract: An integrated airway adapter capable of monitoring any combination of respiratory flow, O2 concentration, and concentrations of one or more of CO2, N2O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO2, N2O, and anesthetic agents.

Abstract: A breath alcohol measuring device includes a flow chamber, for receiving exhaled breathing gas of a person, with a flow diaphragm. A differential pressure sensor has a first measuring connection via a first gas line (5) to the interior space of the flow chamber (2) upstream of the flow diaphragm (3), and a second measuring connection via second and third gas lines (12, 15) and a breath alcohol sensor (8) to the interior space of the flow chamber (2) downstream of the flow diaphragm (3). A throttling element (14) is present in the second gas line (12). The second gas line (12) is connected to a sampling system (9, 10), and an evaluating and control unit (6) is connected to the sensors (4, 8) and to the sampling system (9, 10) for controlling the sampling system.

Abstract: A method of determining bias in a measurement of a constituent concentration level in a sample gas is provided. The method comprises establishing a sample gas flow from an emission stream into a sample gas line of an emissions monitoring system. The method further comprises removing water from the sample gas flow and cooling the sample gas flow to a temperature below about 41° F. to produce a cooled, dried sample gas flow. The constituent concentration level is then determined for the cooled, dried sample gas flow. The method further comprises introducing a span gas having a known span gas constituent concentration level into the sample gas flow to form a combined sample and span gas flow, the span gas being introduced at a desired span gas flow rate. The method still further comprises removing water from the combined sample and span gas and cooling the combined sample and span gas to a temperature below about 41° F. to produce a cooled, dried, combined sample and span gas flow.

Abstract: Disclosed is a system and method for monitoring, diagnosing, and treating certain medical conditions, such as asthma, gastroesophageal reflux or laryngopharyngeal reflux. The system includes a mask apparatus or sensor module fitted with a pH sensor and thermocouple, a continuous positive airway pressure (CPAP) device, a processing receiver, and a therapeutic nebulizer/atomizer/humidifier device. The mask apparatus, CPAP device and therapeutic nebulizer/atomizer/humidifier device are connected by a pneumatic means. The pH sensor and the thermocouple are in electrical communication with the processing receiver that controls, through an electronic means, the CPAP device and therapeutic nebulizer/atomizer/humidifier device. The electrical communications can be in the form of a plurality of wires or employ wireless means.

Abstract: A system includes a laser beam generating device that transmits a wireless first signal, having a first monochromatic radiation level, toward the driver. The first signal bounces off the driver and returns a second signal towards the acetaldehyde level detecting mechanism. A radiation intensity level of the second signal, having a second monochromatic radiation level, is analyzed for determining the driver's blood acetaldehyde level. A mechanism is included for detecting a level of acetaldehyde in a driver's blood stream, which is located within a law enforcement vehicle. A mechanism is included for visually displaying the acetaldehyde level so that the officer can determine whether a threshold level is exceeded. The visually displaying mechanism includes a monitor including a graphical user interface. A mechanism is included for monitoring a location of the vehicle driver so that the officer can track and apprehend the driver.

Abstract: A hand-held device detects the presence of a preselected substance in the breath. A deformable housing forms a test chamber for interacting an indicator reagent with the breath. An ampoule positioned inside the housing is ruptured by manual pressure through the walls of the housing. The contents of the ruptured ampoule are exposed to the breath introduced into the chamber. The presence of a substance in the breath causes the indicator reagent to undergo a visually ascertainable change. The ampoule is secured within the housing by a pair of filter plugs having inboard concavities to receive the rounded ends of the ampoule to center it within the housing, and plural detents prevent slippage of the filters. Additional embodiments lower the user's risk of being cut by glass shards, prevent reagent inhalation, enhance the visual aspects of the device, and physically indicate the presence of breath flowing through the device.

Abstract: A chemical vapor sensor is provided that measures a chemical species of interest with high sensitivity and chemical specificity. In an aspect, an ethanol vapor sensor is provided, sized for being inconspicuous and on-board a vehicle, having a passive measurement mode and an active breathalyzer mode, for detecting a motor vehicle driver that exceeds a legal limit of blood alcohol concentration (BAC), for use with vehicle safety systems. For the passive mode, a vapor concentrator is utilized to amplify a sampled vapor concentration to a detectible level for use with an infrared (IR) detector. In an aspect, ethanol vapor in a vehicle cabin is passively measured and if a predetermined ethanol level is measured, a countermeasure is invoked to improve safety. In an aspect, an active breathalyzer is used as a countermeasure. The active breathalyzer can be imposed for a number of vehicle trips or for a predetermined time period.