Abstract: The present invention describes a replaceable breath alcohol sensor module that can be replaced with a new pre-calibrated breath alcohol sensor module or re-calibrated. The breath alcohol sensor module requiring calibration can be removed from the body of a Breath Alcohol Testing Device (commonly called “breathalyser” or “breathalyzer”). The breath alcohol sensor module can be separately calibrated for accurate calculation of “percent blood alcohol concentration” (% BAC) based on breath air samples and then re-installed into the breath alcohol tester or the old breath alcohol sensor module can be replaced with a new pre-calibrated breath alcohol sensor module. The present invention improves upon and/or replacing the current method of re-calibration at a breathalyzer service center.

Abstract: A measuring head for the analysis of respiratory gases to and from a patient connected to a respirator, includes an aperture (7) which is intended to be placed over an adapter (2) through which respiratory gases flow. The measuring head (1) has a light transmitter (9) which includes an IR-emitter (12) on one side of the aperture (7) and a light receiver (10) which includes an IR-detector on the other side of the aperture (7). The measuring head (1) also includes a signal processing unit (20) necessary for the gas analysis.

Abstract: Methods and systems to screen equipment operators for impairments, such as intoxication, physical impairment, medical impairment, or emotional impairment, to selectively test the equipment operators and control the equipment if impairment of the equipment operator is determined. One embodiment is a method to screen an equipment operator for intoxication. A second embodiment is a method to screen an equipment operator for impairment, such as intoxication, physical impairment, medical impairment, or emotional impairment. A third embodiment is an equipment operator screening system to determine impairment, such as intoxication, physical impairment, medical impairment, or emotional impairment.

Abstract: A vehicle ignition interlock system includes a breath analyzer and a controller operably connected to the breath analyzer and to an ignition system of the vehicle. The breath analyzer detects the breath alcohol level of a vehicle operator and is configured to prevent vehicle ignition if a breath alcohol level is greater than or equal to a threshold value. The controller requires the vehicle operator to periodically take breath analyzer “retests” after vehicle ignition in order to allow vehicle operation to continue. The breath analyzer also detects the presence of alcohol within the vehicle, such as alcohol emanating from an open container of alcohol. The controller may override one or more periodic retests if alcohol is not detected within the vehicle over a predetermined period of time. In addition, the controller may increase the frequency of periodic retests of the vehicle operator in response to detecting alcohol within the vehicle.

Abstract: A method and an apparatus for measuring the concentration of a specific gas component of a gas mixture including another gas whose concentration is independently known using light absorption spectroscopy are provided. A method and an apparatus for assessing human airway inflammation by measuring the concentration of exhaled NO and CO2 present in orally exhaled breath using light absorption spectroscopy are also provided. NO concentration is determined at the time during breath sampling corresponding to a known exhaled CO2 concentration. Methods and apparatus are further provided for measuring NO concentration in orally exhaled human breath that analyze breath emanating from the lower airways and lungs, while excluding breath from the nasal cavity.

Abstract: Parametric characterization of nitric oxide (NO) gas exchange using a two-compartment model of the lungs is a non-invasive technique to characterize inflammatory lung diseases. The technique applies the two-compartment model to parametric characterization of NO gas exchange from a tidal breathing pattern. The model is used to estimate up to six flow-independent parameters, and to study alternate breathing patterns.

Abstract: A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.

Abstract: This invention involves a device and method for ascertaining the functioning of the respiratory system and determining whether a pulmonary embolism is present. The device comprises an apparatus containing sensors which measure the amount of a particular gas expired from a patient's lungs, including a non-ambient gas which is previously provided to the patent. From this data, a processor computes the concentration of expired gas as a function of expired volume and displays the results on a screen. By comparing the results to predetermined values from afflicted and healthy patient populations, an accurate determination can be made regarding the presence of a pulmonary embolism.

Abstract: Disclosed is a system and method for monitoring, diagnosing, and treating certain respiratory conditions, such as asthma. The system includes a mask apparatus fitted with a pH sensor and thermocouple, a continuous positive airway pressure (CPAP) device, a processing receiver, and a therapeutic nebulizer/atomizer/humidifier device. The mask apparatus, CPAP device and therapeutic nebulizer/atomizer/humidifier device are connected by a pneumatic means. The pH sensor and the thermocouple are in electrical communication with the processing receiver that controls, through an electronic means, the CPAP device and therapeutic nebulizer/atomizer/humidifier device. The electrical communications can be in the form of a plurality of wires or employ wireless means.

Abstract: Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

Abstract: The invention resides in a respiratory sonification monitoring method and system for monitoring respiration in a subject including the use of capnometric means for measuring carbon dioxide concentrations, flowmeter means for measuring gas flow and volume of gas; means adapted to process into digital information, signal output from the capnometric means and the flowmeter means, sound synthesizer means adapted to convert the digital information into synthesised audio output, wherein, changes in respiratory flow during inhalation and exhalation, and changes in end tidal carbon dioxide concentrations (ETC02) and cumulative tidal volume (cumVt) of the subject can be represented as changes in synthesised sound heard through a loudspeaker, headphone or ear piece.

Abstract: The invention involves a device and method for ascertaining the functioning of the respiratory system and, in particular, for measuring the efficiency of alveolar ventilation of a patient. The device comprises an apparatus containing sensors for measuring the oxygen and carbon dioxide concentrations as well as the volume of air inhaled and exhaled by a patient. The patient is provided a mouthpiece for breathing into and out of the device, which subsequently measures the oxygen and carbon dioxide partial pressures of inhaled and exhaled air. From these measurements, the efficiency of alveolar ventilation during each tidal volume breath may be calculated.

Abstract: An NDIR spectrometer based on the use of wavelength specific lamp sources, whose emission spectrum consists of discrete, narrow lines characteristic of the isotope present in the lamp, and which it is desired to measure with the spectrometer. This allows very high intrinsic sensitivity, enabling the use of an extremely compact absorption cell with a very short path length. In addition, the source can be self-modulated, such that problems associated with external choppers are avoided. Furthermore, there is insignificant cross sensitivity between the isotopes themselves and between the isotopes and other ambient gases in the operating environment.

Abstract: A method for noninvasively determining the pulmonary capillary blood flow or cardiac output of a patient includes measurement of respiratory flow and carbon dioxide pressure of the patient's breathing. These measurements are used to calculate carbon dioxide elimination and an indicator of the carbon dioxide content of the patient's blood. A geometric relationship between the carbon dioxide elimination data and the data of the indicator of carbon dioxide content is determined. At least one set of the data is modified and at least one other determination of a geometric relationship between the data is made to find the most accurate data set. The data may be modified by filtering or clustering. A slope of at least a portion of the geometric relationship is then used to determine the pulmonary capillary blood flow or cardiac output of the patient.

Abstract: System for detection and analysis of gas samples in fieldable real-time Differential Mobility Spectrometry (DMS) chemical sensor system which uses non-radioactive ion source for monitoring and detecting NOx emissions; provides reliable methods for detecting and monitoring of anthropogenic sources of NOx; also detection of NO in exhaled breath for patient health diagnosis.

Abstract: A method for detecting component concentrations in human gas emissions such as breath and gas emitted from skin. A gas sample containing a specified component is collected into a gas cell using a pump and a series of valves to draw the gas sample into the cell and control the gas pressure within the cell. A tunable optical radiation beam is passed through the gas cell and the amount of energy absorbed by the specified component may be measured indirectly by taking the difference between the incident and emerging beam energy or directly by optoacoustic methods. Concentrations of the specified component as small as 0.1 ppB may be determined. Additionally, the tunable optical radiation beam may be multiplexed for use with a plurality of systems utilizing the beam for medical purposes.

Abstract: A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with molecular beacons or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.

Abstract: A calibration checking device, and methods of mandating its use at regular time intervals, to ensure maintenance of the accuracy of gas analyzers, especially for use with breath tests, Each calibration checking device is designed to be used for a predetermined number of tests. After first connection of a new calibration checking device, a volume of known calibration checking gas is released into the instrument, and a calibration checking measurement is initiated. A signal is sent to a counting mechanism which both enables the use of the instrument, and commences a count of the number of tests performed by the breath tester. When the number of tests is exceeded, the instrument is disenabled. The device can include a moisture filter having an interface with the instrument, which prevents its operation if the filter is used beyond the recommended number of times, or if excess moisture renders it saturated.

Abstract: Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

Abstract: Data representing one or more characteristics of an input airflow (e.g., an airflow associated with a human being, such as breath or an airflow resulting from motion of the human being, or a wind tunnel airflow) is acquired and, if necessary or desirable, processed, then stored, transmitted to a remote location, and/or played back. Playback of acquired airflow data entails generating a display airflow corresponding to the input airflow. The characteristic of an airflow regarding which data is acquired is often the velocity of the airflow, though data regarding other airflow characteristics (e.g., direction, temperature, humidity, odor) can also be acquired in addition to, or instead of, airflow velocity.

Abstract: Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.

Abstract: A liquid separator for separating liquid from gases, comprises a water trap (1) that includes a container (3), a connector (5) for incoming gas flow, a separation chamber (4) that includes a filter and at least one connection passageway for leading separated gas to an analysis instrument. The water trap (1) can be removably fitted in a holder unit (2) connected to the analysis instrument, and the holder unit (2) includes connection devices (15, 16) for receiving the connection passageway.

Abstract: The present invention relates to an assay for evaluating alveolar exchange of oxygen. A 13C-labeled substrate, such as 13C-sodium bicarbonate is administered to a subject by oral or iv intake, and exhaled 13CO2 is measured. The 13CO2 in expired breath can be collected at various time points following administration of the substrate and measured in ? per mil with a mass analyzer or photometer, such as an IR spectrometer. This process can be used as a diagnostic test for the indication of, treatment and/or evaluation of the severity of respiratory tract diseases or infections.

Abstract: A method for detecting ?-oxoaldehydes in the whole blood, blood plasma and/or serum of a patient. A respiratory air sample is analyzed for the presence of at least one ?-oxoaldehyde, and the presence of ?-oxoaldehydes in the whole blood, blood plasma and/or serum of the patient is determined from the results of the analysis.

Abstract: The invention involves a device and method for ascertaining the functioning of the respiratory system and determining whether a pulmonary embolism is present. The device comprises an apparatus containing sensors which measure the amount of a particular gas expired from a patient's lungs, including a non-ambient gas which is previously provided to the patent. From this data, a processor computes the concentration of expired gas as a function of expired volume and displays the results on a screen. By comparing the results to predetermined values from afflicted and healthy patient populations, an accurate determination can be made regarding the presence of a pulmonary embolism.

Abstract: Disclosed is an exhalation gaseous component gauge including, in a palm-sized casing having exhalation taking-in and taking-out slots made on its front and rear sides, a semiconductor gas sensor so placed that the air flowing from one's mouth may pass the sensor, a CPU responsive to the signal from the sensor for determining the quantity of the exhalation gaseous components, and a display for showing the so determined result. The palm-sized casing is so sized and configured as to permit one to have a look at the display while holding the gauge in hand to direct the air from the mouth to the exhalation taking-in slot. Also, disclosed is a cellular phone equipped with an exhalation gaseous component gauge.

Abstract: The present invention provides methods for detecting the presence of an analyte indicative of various medical conditions, including halitosis, periodontal disease and other diseases are also disclosed.

Abstract: Method and apparatus for determining in a person's exhalation air the concentration of a specific substance in the blood by measuring the concentration of said substance and the concentration of water vapor in the exhalation air and utilizing a known relationship between these concentrations. When the method is applied the exhalation air is exhaled freely in a defined air volume having a predetermined composition, and said concentrations are measured in this air volume. The apparatus for working the method comprises a device (16) which defines a space for receiving the exhalation air, which has two mutually opposite openings through which the space communicates with the surrounding air, and means (18, 22, 23) for selective quantitative detection of said substance in the air in the defined space.

Abstract: A breath measurement instrument using a combination of breath pressure, temperature, and humidity measurements to determine whether or not breath samples are human and properly delivered. Valid samples require maintenance of a threshold dynamic pressure of a sample being introduced for a predetermined time, a valid temperature of the sample and a valid humidity of the sample, wherein the range of valid sample temperatures is adjusted according to a measured sample humidity. Also disclosed is a breath alcohol instrument having an alcohol-specific fuel cell and a fuel cell circuit for generating a breath alcohol signal. Further disclosed is an interlock system for inhibiting operation of machinery such as a vehicle, and a method for screening breath samples and determining an alcohol content thereof.

Abstract: The present invention provides an apparatus to analyze breath gas for diagnosing diabetes. The apparatus determines acetone levels in breath gas samples and provides a diagnostic results based on the acetone levels. The present invention further provides a method of using such apparatus to distinguish healthy people and patients with early diabetes or sever diabetes.

Abstract: A system, device, and method for determining whether an individual has consumed, is intoxicated, or is otherwise impaired by alcohol is disclosed. Further, a device capable of positively identifying the person who provides the impairment test is disclosed. The impairment detection and interlock system disclosed accomplishes this with the use of a video camera that selectively saves images, and an attitude evaluator and, in some embodiments, an exposure evaluator, which ensures that the video camera captures the identity of the tester. A device holster may also be used to facilitate video surveillance.

Abstract: The present invention includes a method and apparatus for monitoring drug compliance by detecting markers, such as odors, upon exhalation by a patient after medication is taken, wherein such markers result either directly from the medication itself or from an additive combined with the medication. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial noses” or “electronic noses,” to non-invasively monitor compliance. The invention further includes a reporting system capable of tracking compliance (remote or proximate) and providing the necessary alerts.

Abstract: A Voice recognition Breathalyzer comprises of a microphone for transducing spoken expression into electronic signals and a breathalyzer sensor for transducing given breath content into electronic signals. An audio and breathalyzer sensor circuit for conditioning said electronic signals from said microphone and breathalyzer sensor; a memory storage for storing speech templates and toxic breath setting; a processor for processing said conditioned electronic signals and for simultaneously comparing the processed, conditioned electronic signals with said speech templates and said toxic breath setting threshold stored in said memory storage, said processor generating a unique signal when said processed, conditioned electronic signals are substantially similar to one of said speech templates and below said toxic breath setting threshold. In the preferred embodiment of invention said voice recognition breathalyzer is mobil and it's powered by a battery and said unique signals are transmitted by an RF link.

Abstract: A rapid, non-invasive breath-test method and device for diagnosing the presence or absence of H. pylori in a subject without administration of isotopic tracers is described. The device consists of a highly sensitive colorimetric ammonia sensor placed in contact with sampled subject breath. The sensor is measured using appropriate reflection spectroscopy instrumentation. The breath-test method consists of measuring a basal ammonia level with the device, administering non-isotopic urea and continuing measurement of the ammonia content in a plurality of consecutive breaths. Diagnostic differences in breath ammonia are identified between H. pylori infected and uninfected individuals.

Abstract: A top and bottom housing joined together have a patient port and ventilation port in axial alignment. The top housing contains dry indicator paper for changing color in response to the presence of CO2. In addition, a shaft having a pointer on a top portion rotates in response to air in the housing to indicate pressure. A helical outer wall of the shaft engages a notch in a hollow stem attached to a membrane in the lower housing so the shaft rotates in response to air pressure on the membrane.

Abstract: A new method and a device are disclosed to determine physiologic parameters of a subject by analyzing it's breathing gas with an electrochemical sensor. The measured components of the breathing gas allow for many conclusions about the condition of the subjects's pulmonary system. It is therefore an objective of this invention to determine physiologic parameters from measuring the partial pressure of oxygen in the mainstream of the breathing gas. According to the invention the measurement can be performed non invasive and allows for conclusions about the respiratory and metabolic system of a subject. The invention makes a continuous measurement of the oxygen partial pressure possible, that almost shows no time delay. The invention allows for instance the determination of parameters like the oxygen concentration in the breathing gas, the oxygen consumption of the subject, the heart frequency, the respiratory quotient, the compliance of the pulmonary tract and other physiologic parameters.

Abstract: An optical sensor is proposed for determining gases in gas mixtures, especially for determining one gas component in the air, having a sensitive layer exposed to the gas and having a device for detecting a change in an optical property of the sensitive layer. The sensitive layer of the sensor contains a phosphorus or nitrogen-containing base having numerous and/or long-chain alkyl groups for the pH adjustment of the sensitive layer.

Abstract: Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.

Abstract: The invention presents techniques for identifying and guiding treatment for medical conditions, based upon the carbon dioxide concentration in the patient's breath. In an exemplary application, the techniques of the invention may be used to distinguish obstructive lung disease from restrictive lung disease, even though the symptoms of the conditions are similar. The techniques of the invention may further be used to monitor the effectiveness of the treatment.

Abstract: Apparatus or systems which employ luminescence-quenching to produce a signal indicative of oxygen concentration.

Abstract: The invention relates to an inexpensive method in which the partial pressure of a gas component in the air exhaled by a patient is determined per breath.

Abstract: The disturbing influence or orally produced nitric oxide in the measuring of exhaled nitric oxide can be ameliorated or totally eliminated through the use of a method and composition according to the present invention. The production of NO in the oral cavity is temporarily inhibited by the application of a composition having anti-bacterial and/or pH increasing effect.

Abstract: An apparatus and method for assuring that a machine operator is not under the influence of a chemical, comprising a first sensor positioned proximally to the machine operator and adapted for, measuring a vapor concentration proximal thereto, a second sensor positioned distally from the machine operator and adapted for measuring the vapor concentration distally from the operator, a device for comparing the proximal and distal vapor concentrations, and an automated remediating device responsive to the comparing device when the ratio of the first and the second vapor concentrations are within a specified range.

Abstract: The presence of a pathologic process in a lung of a mammal is detected by applying exhaled gas of a mammal to an electronic nose. Data derived from the electronic nose is used to determine whether a pathologic process is present in the lung of the mammal. The pathologic process may be a lung infection such as pneumonia.

Abstract: A method for detecting the occurrence of a condition in a respiring subject includes the steps of: introducing emitted subject respiratory gases to a gas sensing device; detecting certain species present in the emitted subject respiratory gases with the gas sensing device; and correlating the presence of the species with the occurrence of the condition.

Abstract: Apparatus or systems which employ luminescence quenching to produce a signal indicative of oxygen concentration. Components of such systems include: an airway adapter, sampling cell, or the like, having a sensor which is excited into luminescence with the luminescence decaying in a manner reflecting the concentration of oxygen in gases flowing through the airway adapter or other flow device; a transducer which has a light source for exciting a luminescable composition in the sensor into luminescence and a light sensitive detector for converting energy emitted from the luminescing composition as that composition is quenched into an electrical signal indicative of oxygen concentration in the gases being monitored; and subsystems for maintaining the sensor temperature constant and for processing the signal generated by the light sensitive detector.

Abstract: A portable olfactometer for sensing and measuring odors by sniffing has a barrel which carries selectively different D/T ratios of odorous air to a nose mask and has a selective set of inserts for providing different D/T ratios at the input to the barrel.

Abstract: A method for determining the quantity and identity of an electrochemically convertible substance in a gas sample. The substance is converted in an electrochemical sensor producing an electrical output. The characteristic parameters of a curve-defining equation y(t)=k×(e−axt−e−bxt) are calculated based on three measurements of output at times t, 2t, and 4t. The integral under all or part of the curve is calculated to determine the quantity of the substance. The equation parameters are compared with standard values to determine the identity of the substance.

Abstract: Device for measuring the alcohol vapor concentration in a sample, wherein the device comprises an electrochemical sensor capable of monitoring alcohol through a diffusion current, means for determining the limiting diffusion current and means for generating an alcohol vapor concentration signal from the determined limiting diffusion current.

Abstract: The invention involves a device and method for ascertaining the functioning of the respiratory system and determining whether a pulmonary embolism is present. The device comprises an apparatus containing sensors for measuring the oxygen and carbon dioxide concentrations as well as the volume of air inhaled and exhaled by a patient. From this data, a processor computes the ratio of carbon dioxide to oxygen for the volume of expired air and displays the results on a screen. By comparing the results to predetermined normal values, an accurate determination can be made regarding the presence of a pulmonary embolism.