Food Or Edible As Carrier For Pharmaceutical Patents (Class 424/439)
  • Patent number: 9125926
    Abstract: Provided are compositions comprising an active ingredient having antispasmodic and/or prokinetic activity, preferably vicenin 2 or biologically active analogs thereof.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 8, 2015
    Assignee: AMINO UP CHEMICAL CO. LTD
    Inventors: Hajime Fujii, Sybille Buchwald-Werner
  • Patent number: 9084730
    Abstract: The present invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically acceptable polymer matrix, a characterized in that said pharmaceutically acceptable polymer matrix comprises a blend of (i) polydextrose, in the form of a continuous polydextrose phase, in order to promote the disintegration of the composition in an aqueous medium, and (ii) at least one polymer other than polydextrose, in the form of a continuous phase of this polymer, whereby the polydextrose is in a concentration of at least 20 wt % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt % in relation to the total weight of said pharmaceutically acceptable polymer matrix.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: July 21, 2015
    Assignee: SANOFI
    Inventors: Michel Bedos, Thierry Breul, Stephen Byard, Isabel Ribeiro Dos Santos
  • Patent number: 9085520
    Abstract: Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 21, 2015
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Ying-Chi Du, Yi-Hong Tsai, Chi-Ting Hsieh
  • Patent number: 9060979
    Abstract: An antidepressant containing, as an active ingredient, at least one compound selected from a branched amino acid, a pharmaceutically acceptable salt thereof and a derivative thereof.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: June 23, 2015
    Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.
    Inventor: Masako Doi
  • Patent number: 9060996
    Abstract: Compositions and methods for providing infant nutrition with partially hydrolysed proteins and non-digestible oligosaccharides for use in induction of oral tolerance against native dietary proteins.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: June 23, 2015
    Assignee: N.V. NUTRICIA
    Inventors: Léon Mathieu Johannes Knippels, Elisabeth Catharina Adriana Maria Van Esch, Johan Garssen
  • Patent number: 9049879
    Abstract: The disclosure relates to an edible energy composition that includes a methylated xanthine, a choline derivative and a flavorant.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: June 9, 2015
    Assignee: International IP Holdings LLC
    Inventor: Manoj Bhargava
  • Patent number: 9044043
    Abstract: This invention relates to a balanced fat composition and use thereof in a liquid nutritional composition, in particular suitable for tube feeding. This invention further relates to said liquid nutritional composition for providing enteral nutrition to patients in need thereof, in particular for providing a complete enteral nutrition, in particular for providing a long-term enteral nutrition. More specifically, the balanced fat composition and the liquid nutritional composition comprising said balanced fat composition comprises specific amounts of linoleic acid (LA), alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), at least one medium chain fatty acid (MCFA), and at least one mono-unsaturated fatty acid (MUFA). The invention relates further to a method for providing enteral nutrition to patients in need thereof comprising administering an effective amount of said liquid nutritional composition comprising the balanced fat composition according to the invention.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: June 2, 2015
    Assignee: N.V. NUTRICIA
    Inventors: Rogier Daniël van Anholt, Zandrie Hofman, Wynette Hermina Agnes Kiers
  • Patent number: 9040075
    Abstract: Disclosed is a method of increasing lean body mass and reducing fat body mass in infants, said method comprising administration to an infant, term or preterm, a nutritional formula comprising a source of DHA and ARA. It has been found that the administration of DHA and ARA, or a source thereof, in infants can increase lean body mass and reduce fat body mass, when compared to an unsupplemented control formula, without impacting the total overall growth of the infant. This method is especially useful in preterm infants.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 26, 2015
    Assignee: ABBOTT LABORATORIES
    Inventors: Nancy Auestad, Joan R. Jacobs
  • Patent number: 9034366
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA either alone or in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 19, 2015
    Assignee: U.S. Nutraceuticals, LLC
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Publication number: 20150132359
    Abstract: Compositions of reducing agents and carriers for producing a stable negative oxidation reduction potential in consumable materials are disclosed and claimed. Compositions of the invention find use in enhancing the hydration and anti-oxidant value of consumable materials such as foods, beverages and cosmetics, for example. Compositions of the invention also find use in water treatment, agricultural and scientific research applications. Methods for using and making the compositions are also within the scope of the invention.
    Type: Application
    Filed: September 7, 2014
    Publication date: May 14, 2015
    Inventor: DUSAN MILJKOVIC
  • Patent number: 9028882
    Abstract: A nutriceutical food product includes a solid polymeric matrix and a liquid combined into a gel. The nutriceutical food product may include an immune modulator, such as transfer factor and/or a nanofraction immune modulator. A fruit component may be included in the nutriceutical food product. The fruit component may include at least one oligoproanthocyanidin-containing fruit, such as açai.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: May 12, 2015
    Assignee: 4Life Patents, LLC
    Inventors: Brent M. Vaughan, Calvin W. McCausland, David A. Lisonbee
  • Patent number: 9028814
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA either alone or in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: May 12, 2015
    Assignee: U.S. Nutraceuticals, LLC
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Patent number: 9023381
    Abstract: Pharmacologically effective amounts of a medication are delivered in pleasant tasting delivery vehicles, including gelatins and candies. Mechanisms for the reduction in surface area of noxious taste-imparting aspects of conventional medicines, and dilutive effects of positive masking elements for such medicines, especially products for inducing children to take medicines, are taught—in combination with processes and products thereby.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 5, 2015
    Inventor: Michelle Chow
  • Publication number: 20150118280
    Abstract: The present invention relates to means for protecting bioactive materials in mammalian food or feed formulations used to enhance the health status of mammals.
    Type: Application
    Filed: November 3, 2014
    Publication date: April 30, 2015
    Inventors: Amir Barzilay, Hagit Koren-Lichtig
  • Patent number: 9017702
    Abstract: A formulation includes one or more active ingredients of poor water solubility for medical or non-medical use in the rearing of animals. The formulation is suitable for administration to the animals via their drinking water. It exhibits superior stability. The formulation comprises an active ingredient, a thickener combination and water, wherein the thickener combination comprises at least one thickener selected from the following groups A, B, C and D: (A) cellulose derivatives, such as methyl cellulose, sodium carboxy methyl cellulose, (B) non-cellulosic polysaccharide thickeners such as xanthan gums, Arabic gum, (C) cross-linked polyacrylic acid polymers, (D) hydrocolloidal hydrated silicates.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: April 28, 2015
    Assignee: KRKA, D.D., Novo Mesto
    Inventors: Denise Leskovar, Franc Vrecer, Andrejka Kramar, Ivanka Kolenc, Ivan Gobec, Helena Princ
  • Publication number: 20150104493
    Abstract: A consumable film adapted to adhere and to dissolve in the oral cavity that provides a local anesthetic and therapeutic agents for the treatment of oral burns or injuries. The film is designed to instantly release benzocaine, or other types of local anesthetic or therapeutic agent, upon adhesion to the affected areas of the mouth, and will continue to release sufficient quantities for pain relief and for healing over an extended period of time.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Inventors: Robert W. McDonald, III, Kurt Fraivillig, Adriane Shciano, Elizabeth Vansant, Lance Hansen
  • Patent number: 8999372
    Abstract: Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use are disclosed.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: April 7, 2015
    Assignee: CURE Pharmaceutical Corporation
    Inventors: Robert S. Davidson, Gary Kehoe
  • Patent number: 8999373
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA either alone or in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: April 7, 2015
    Assignee: U.S. Nutraceuticals, LLC
    Inventors: John. A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Patent number: 8999374
    Abstract: The present invention is to provide a ?-1,4-mannobiose-containing composition which can inhibit colonization of salmonella in animal body and effectively excrete salmonella outside the body and the method for producing thereof, a feed additive containing the ?-1,4-mannobiose-containing composition, and a feed blended with the ?-1,4-mannobiose-containing composition.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: April 7, 2015
    Assignee: Fuji Oil Co., Ltd.
    Inventors: Toshimichi Morikoshi, Futoshi Yokomizo
  • Patent number: 8986735
    Abstract: A solid dosage form containing a taste masked active agent is provided. The solid dosage form may be provided as a water soluble film that is disintegrable in the oral cavity to deliver and release the taste masked active agent. The disintegrable film includes at least one water soluble polymer and a taste masked ketoprofen active. Also provided are methods for preparing the solid dosage form and for using the solid dosage to administer an effective dosage of an active agent, such as ketoprofen, into the oral cavity for absorption.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 24, 2015
    Assignee: Novartis AG
    Inventors: Alexander M Schobel, Shyam S Vangala
  • Patent number: 8986729
    Abstract: The invention relates to a liquid vehicle that can be used to create suspensions and/or solutions of liquid or powdered medications. The vehicle is thixotropic and has improved stability and rheologic characteristics. Vehicles of the invention include an aqueous medium and a suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages. The polysaccharide can be a starch, modified starch, or glycogen. The aqueous medium and individual components of the vehicle provide a palatable and easily ingested drug preparation. The invention also provides a vehicle containing an aqueous medium, suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages, buffer, and artificial sweetener, the combined suspending vehicle having a pH of about 3 to about 10 and an osmolality of 300 mOmsol or less.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: March 24, 2015
    Assignee: Fagron, Inc.
    Inventors: Joshua Radke, Michael Jones, Martin Erickson
  • Publication number: 20150079149
    Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventor: Alessandra Grassi
  • Patent number: 8980307
    Abstract: Methods and compositions are provided for increasing the anaerobic working capacity of muscle and other tissues. Also provided are compositions formulated for the sustained release of free beta-alanine. Also provided is a dietary supplement formulated, for example, as a solid food product, an edible suspension, liquid or semi-liquid as described herein.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: March 17, 2015
    Assignee: Natural Alternatives International, Inc.
    Inventors: Roger Harris, John Wise
  • Patent number: 8968768
    Abstract: The invention provides a nutritional supplement which includes phytosterol to facilitate reduction of cholesterol. The nutritional supplement may be a swallowable tablet, chewable tablet, sachet, capsule or suspension. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized swallowable tablet and a method for reducing blood cholesterol in humans.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: March 3, 2015
    Assignee: Wyeth LLC
    Inventors: Scott W. Poxon, William Bubnis, Bruce W. Sutton, Jeffrey V. Vernon, Denise L. Walters, Michael G. Williams, Neil Wittenberg
  • Patent number: 8951550
    Abstract: Dietary formulations in the form of an oil emulsion providing total enteral or parenteral nutrition, or in the form of food oil suitable for oral administration is provided. The formulations include about 2-60% by calories of a C20 or longer omega-3 fatty acid and about 0.05% to 1% by calories of arachidonic acid, where the formulation provides less than 1% of total calories from linoleic acid and alpha-linolenic acid, and where the fatty acids provide 5-60% of the total calories of said dietary formulation. Methods for treatment of diseases and disorders using the dietary formulations are also provided.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: February 10, 2015
    Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Mark Puder, Bruce Bistrian
  • Patent number: 8951549
    Abstract: The invention relates to a method for reducing the concentration of amines and salts thereof, wherein the amines have the general chemical formula I R1R2R3N and the salts have the formula II R1R2R3N—H, wherein the amines and salts thereof exist in aqueous solution or aqueous suspension and are brought into contact with clinoptilolitic or clinoptilolite-containing mixtures. The method itself is suitable for use in food preparation and in the manufacture of foods. The inventive idea of reducing the concentration of amines and salts thereof is also useful in the manufacture of medical products for absorbing and for removing amines from the intestinal tract or the skin area of humans and animals.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: February 10, 2015
    Assignee: Froximun AG
    Inventors: Günter Steimecke, Steffen Hoffmann, Thomas Görner
  • Patent number: 8951576
    Abstract: A process for producing aqueous chlorous acid solution in which chlorous acid, which is safe for the human body, is easy to handle, and less generates chlorine dioxide, is yielded and used as a disinfectant for a pretreatment in food processing. To an aqueous sodium chlorate solution is added sulfuric acid or an aqueous solution thereof in such an amount and concentration that the pH of the aqueous solution can be kept at 2.3-3.4 to thereby react them and generate chloric acid. Subsequently, hydrogen peroxide is added to the chloric acid in an amount which is equal to or larger than the amount necessary for a reduction reaction to thereby yield chlorous acid. Any one of inorganic acids, inorganic acid salts, organic acids, and organic acid salts, or two or more thereof, or a combination or these is added to the aqueous solution containing chlorous acid yielded, whereby the chlorous and acid can be present for long and the pH of the aqueous solution is regulated to regulated to 3.2-7.0.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: February 10, 2015
    Assignee: Honbu Sankei Co., Ltd.
    Inventor: Hisataka Goda
  • Publication number: 20150037388
    Abstract: The invention relates, in one aspect, to a mucoadhesive edible slow dissolving film comprising a salt of alginic acid, an edible cellulose derivative, an edible protein, and edible polymer delaying the dissolution in a physiological fluid of the edible film selected from polyvinylpyrrolidone, a carboxyvinyl polymer and mixtures thereof, in an amount effective to delay the dissolution time of the film in a biological fluid. The edible film is suitable for cicatrizing oral ulcerations or lesions or for forming a layer on oral mucosae or gingiva affected by ulcerations or lesions for protecting against mechanical abrasions, infections or caustic agents.
    Type: Application
    Filed: January 28, 2013
    Publication date: February 5, 2015
    Inventor: Sonia Longo
  • Publication number: 20150037389
    Abstract: The present invention relates to an edible product, which comprises a fibrous plant product and a plant extract applied thereto. Further, the invention relates to a corresponding method for producing said edible product and its use in at least one of food, food supplement, medicinal, cosmetic, well-being, nutraceutical or phytotherapeutical applications. The plants used may be all plants comprising one or more substances of interest for an edible product.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Inventors: Philippe Ragot, Esther Pons, Bernard Mompon, Cedric Rousseau
  • Patent number: 8945608
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: February 3, 2015
    Assignee: U.S. Nutraceuticals, LLC
    Inventors: John. A. Minatelli, W. Stephen Hill, Swati Sebastian Thomas, Lingan Rajendran, Rudi E. Moerck
  • Publication number: 20150017223
    Abstract: Described herein is an edible coating for food products in which the coatings comprises a polysaccharide cross-linked with a cross-linking agent solution. Also described herein are methods for coating food products and forming clusters of food products. The use of the edible coating for extending the shelf-life of food products is also described.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 15, 2015
    Applicant: FRUITSYMBIOSE INC.
    Inventor: Genevieve Girard
  • Patent number: 8921422
    Abstract: Processes for enhancing ability to learn in a puppy or kitten comprising orally administering to the puppy or kitten a composition comprising an essential fatty acid component comprising a therapeutically effective amount of docosahexaenoic acid. Processes for enhancing ability to learn in a puppy or kitten comprising orally administering to a respective maternal animal a composition comprising an essential fatty acid component comprising a therapeutically effective amount of docosahexaenoic acid during gestation, nursing, or weaning of the puppy or kitten. Kits comprising a composition comprising an essential fatty acid component comprising a therapeutically effective amount of docosahexaenoic acid; and information that use of the composition will enhance ability to learn in a puppy or kitten.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: December 30, 2014
    Assignee: The Iams Company
    Inventor: Russell Lee Kelley
  • Patent number: 8920746
    Abstract: The present invention relates to devices and systems for detecting the existence of oral conditions.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 30, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Douglas Hohlbein, Elizabeth Gittens, Harsh M. Trivedi, Sharon Kennedy, Madhusudan Patel, Deborah Peru
  • Patent number: 8916150
    Abstract: Methods and compositions are provided for increasing responsiveness to therapeutic metalloproteases including increasing and/or maximizing responsiveness and preventing botulinum and tetanus toxin resistance due to a functional deficiency of zinc. Also provided are methods for zinc replacement or supplement in lacking individuals comprising the administration of a zinc supplement for a loading period and/or administration of a phytase supplement together with the zinc supplement. Also provided are methods for standardization of botulinum toxin potency assays that provide for greater certainty and margins of safety in the use of products from different manufacturers.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: December 23, 2014
    Assignee: CNSS IP Holdings, Inc.
    Inventor: Charles N. S. Soparkar
  • Patent number: 8916145
    Abstract: The invention relates to the use, in the manufacture of a medicament or a therapeutic nutritional composition for preventing or reducing inflammation in a mammal, of bifidobacterium longum ATCC BAA-999.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: December 23, 2014
    Assignee: Nestec S.A.
    Inventors: Annick Mercenier, Stephanie Blum-Sperisen, Florence Rochat
  • Patent number: 8916612
    Abstract: The invention is dietary supplements, nutraceutical compositions, medical foods, and animal feeds that have cytoprotective (cell and tissue protection) and health promoting effects. The compositions contain a high dose range of agmatine and nutraceutical acceptable salts thereof as dietary fortification for providing effective long-term cytoprotection and affording for soft stool. The compositions may contain agmatine alone or in combination with other dietary ingredients having health promoting effects. The compositions can be prepared with dietary accepted excipients and compatible forms of carriers, including but not limited to, powders, tablets, capsules, controlled release carriers, lozenges and chewable preparations, liquid suspensions, suspensions in an edible supporting matrix or foodstuff and oral rehydration solutions, to enable consumption of said compositions.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: December 23, 2014
    Inventors: Gad Gilad, Varda Gilad
  • Patent number: 8911769
    Abstract: The invention relates to pharmaceutical compositions suitable for oral administration in the form of edible films comprising diclofenac.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: December 16, 2014
    Assignee: Novartis AG
    Inventors: Gavin Murray Spencer, Alexander Mark Schobel, Greg Slominski, Stephan Meyer, Isabelle Rault
  • Patent number: 8911770
    Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: December 16, 2014
    Inventor: Alessandra Grassi
  • Patent number: 8911803
    Abstract: A complete nutritional composition comprising polyphenols is provided for reducing the symptoms of allergies originating from food allergens in young children or infants. Preferably the composition modulates the secondary prevention of allergies while not affecting significantly the primary prevention. The composition comprises an apple extract.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: December 16, 2014
    Assignee: Nestec S.A.
    Inventors: Sebastien Holvoet, Annick Mercenier, Adrian Zuercher
  • Patent number: 8906405
    Abstract: A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, reactive oxygen species.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: December 9, 2014
    Assignee: Retrotope, Inc.
    Inventor: Mikhail Sergeevich Shchepinov
  • Patent number: 8906406
    Abstract: The invention relates to a mucoadhesive medicinal preparation for administering active substances in veterinary or humane medicine, containing at least one active substance, which preparation is characterized in that it is a mucoadhesive matrix disintegratable in aqueous media, which matrix contains at least one matrix-forming polymer and wherein at least one active substance is dissolved or dispersed, and in that the said preparation disintegrates or erodes within maximally 15 minutes after introduction in an aqueous medium or in body fluids, or in that the preparation initially gels within maximally 15 min after its introduction in an aqueous medium or in body fluids, and disintegrates or erodes within maximally 30 min after said introduction.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 9, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Tina Rademacher, Frank Seibertz, Petra Brandt, Markus Krumme, Christian Von Falkenhausen
  • Patent number: 8900623
    Abstract: The present invention is directed to a composition, kit and method for delivering a soft flowable gel to a flock of poultry in barns, but can also be used in hatcheries or free range farms, for treating poultry with a therapeutic agent. The soft flowable gel comprises water, a gelling agent, a therapeutic agent and between about 0.05% and 0.15% xanthan gum.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: December 2, 2014
    Assignee: Vetech Laboratories Inc.
    Inventor: Eng-Hong Lee
  • Patent number: 8895050
    Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: November 25, 2014
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Andrew P. Patron, Sara L. Adamski-Werner, Farid Bakir, Qing Chen, Vincent Darmohusodo, Stephen Terrence Hobson, Xiaodong Li, Ming Qi, Daniel H. Rogers, Marketa Rinnova, Guy Servant, Xiao-Qing Tang, Mark Zoller, David Wallace, Amy Xing, Klaus Gubernator
  • Patent number: 8895051
    Abstract: A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 25, 2014
    Inventors: Laman Alani, Donald P. Gauwitz, Dilip Kaul, John M. Lipari, Soumojeet Ghosh, Kennan C. Marsh, Richard H. Whelan, Vanik D. Petrossian
  • Patent number: 8883133
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 11, 2014
    Assignee: Valorisation-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8883191
    Abstract: A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w), of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Wolfgang Laux
  • Patent number: 8877232
    Abstract: The present invention relates to means for protecting bioactive materials in mammalian food or feed formulations used to enhance the health status of mammals.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: November 4, 2014
    Assignee: Nutrinia Ltd.
    Inventors: Amir Barzilay, Hagit Koren-Lichtig
  • Patent number: 8871267
    Abstract: The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: October 28, 2014
    Assignee: Gel-Del Technologies, Inc.
    Inventor: David B. Masters
  • Patent number: 8871281
    Abstract: The invention provides compounds for use in a method of treating oral pharyngeal dysphagia in an individual and related products. One embodiment of the invention comprises administering to an individual an effective amount of a vanilloid receptor 1 (VR-1) agonist or high-affinity partial agonist to promote a swallow reflex.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: October 28, 2014
    Assignee: Nestec S.A.
    Inventor: Kevin Burke Miller
  • Patent number: 8865202
    Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: October 21, 2014
    Assignee: LTS LOHMANN Therapie-Systeme AG
    Inventors: Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino