Abstract: Non-compressed sustained release tablets which will float on gastric fulid are described. The tablets comprise a hydrocolloid gelling agent, the selected therapeutic agent and water.
Type:
Grant
Filed:
July 1, 1987
Date of Patent:
March 21, 1989
Inventors:
Sanford Bolton, Philip H. Izevbehai, Subhash Desai
Abstract: Non-compressed sustained release tablets which will float on gastric fluid are described. The tablets comprise a hydrocolloid gelling agent, a therapeutically acceptable inert oil, the selected therapeutic agent and water.
Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
Type:
Grant
Filed:
September 3, 1987
Date of Patent:
March 21, 1989
Assignee:
ALZA Corporation
Inventors:
Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50.degree. to 180.degree. C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.
Type:
Grant
Filed:
April 6, 1987
Date of Patent:
January 31, 1989
Assignee:
BASF Aktiengesellschaft
Inventors:
Hans-Helmut Goertz, Roger G. Klimesch, Klaus Laemmerhirt, Siegfried Lang, Axel Sanner, Reinhard Spengler
Abstract: The discovery presented herewith concerns a pharmaceutical product in the form of a pellet with improved continous, delayed medicament substance emission through a coating, which is made of a material that does not dilute in gastric and intestinal juices and which is impermeable for gastric and intestinal juices and which tightly seals the core made of material that is dilutable in gastric and intestinal juices.
Abstract: The present invention is a multidose capsule including a tube having a first end and a second end and a dividing wall, supported by the tube, which separates the tube into first and second chambers. First and second removably supportable caps are slidable along each tube end to the extent sufficient to securely seal the chamber thereunder. In alternative embodiments both the dividing wall and the capsule periphery with respect thereto are frangible such that the capsule may be broken in two under an applied stress.
Abstract: A device for zero order releasing of biologically active substances into a fluid medium comprising a cylindrical tablet or bolus covered with an impermeable wall or coating from which strips of said wall or coating have been removed.
Abstract: Colored intagliated articles, for example colored intagliated pharmaceutical tablets, on which the intagliations are highlighted. The articles are colored intagliated articles bearing a layer consisting essentially of a defined optically anisotropic substance, for example magnesium carbonate. Process for manufacturing said articles.
Abstract: A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.
Abstract: An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
Type:
Grant
Filed:
January 7, 1987
Date of Patent:
June 14, 1988
Assignee:
Alza Corporation
Inventors:
Paul R. Magruder, Brian Barclay, Patrick S. L. Wong, Felix Theeuwes
Abstract: A bisectable drug tablet having an elongated tablet body with a length greater than its width. The tablet body also has top and bottom surfaces with a concavity being provided in each thereof. A breaking groove is formed in at least one of the concavities and extends laterally across the width of the tablet at an apex of the one cavity. Thus, upon application of a downward pressure to either the top or bottom surfaces of the tablet, when the other of the top and bottom surfaces faces downwardly and the opposite longitudinal ends of the tablet rest on a support surface, the tablet will fracture along the groove, the fracture occurring irrespective of whether the breaking groove faces toward or away from the support surface.
Abstract: Coated articles, for example colored pharmaceutical tablets, bearing highlighted intagliations. The articles are colored intagliated articles bearing at least one film coat comprising at least one optically anisotropic substance, for example magnesium carbonate, and at least one film coating agent. Process for manufacturing said articles.
Abstract: A novel divisible delayed release pharmaceutical tablet, wherein the rate of release of active ingredient is independent of the size and nature of the total surface area, and the fragments of which have the same characteristics of release of active ingredient as the undivided tablet.
Abstract: A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.
Abstract: A dispensing system is disclosed for delivering a beneficial agent. The dispensing system comprises (1) a housing defining an internal space, (2) a gas-generating composition in the space, (3) a dense member in the space, (4) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (5) a passageway in the housing for delivering the beneficial agent for the dispensing system.
Abstract: A device for the release of a diffusible solid in a fluid medium which comprises a disc which comprises a substantially uniform mixture of said diffusible solid and a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid. The surfaces of said disc are coated with a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid, with the exception of one or more apertures which extend through the disc and expose a portion of the mixture of diffusible solid and polymer to the fluid medium when the device is immersed therein. The aperture or apertures are placed in said disc such that as said fluid medium enters the disc through said aperture or apertures, the ratio of surfce area of diffusible solid exposed to the fluid medium to the length of the path through which the exposed solid must diffuse to exit the disc remains substantially constant.
Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
Type:
Grant
Filed:
February 14, 1986
Date of Patent:
May 5, 1987
Assignee:
Alza Corporation
Inventors:
James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
Abstract: Colored intagliated articles, for example colored intagliated pharmaceutical tablets, on which the intagliations are highlighted. The articles are colored intagliated articles bearing a layer consisting essentially of a defined optically anisotropic substance, for example magnesium carbonate. Process for manufacturing said articles.
Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an alkaloid.
Type:
Grant
Filed:
December 19, 1985
Date of Patent:
March 3, 1987
Assignee:
Warner-Lambert Company
Inventors:
David Peters, John Denick, Jr., Anil K. Talwar
Abstract: The invention describes a pharmaceutical dosage unit suitable for oral administration with at least one face having a recess, which recess extends from one edge across and into the face; the recess being so shaped as to accommodate at least the tip of the user's tongue.
Type:
Grant
Filed:
December 21, 1984
Date of Patent:
March 3, 1987
Assignee:
Smith Kline & French Laboratories Limited