Natural Gums, Resin Or Latex Patents (Class 424/485)
  • Patent number: 7357943
    Abstract: The present invention relates to the field of pharmaceutical technology and describes a novel pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient, in particular an acid-labile proton pump inhibitor. The invention also relates to processes for producing the suspension. The suspension is particularly suitable for administering acid-labile active ingredients to people who have difficulty taking solid dosage forms such as tablets or capsules.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: April 15, 2008
    Assignee: Nycomed GmbH
    Inventors: Rudolf Linder, Rango Dietrich
  • Publication number: 20080085304
    Abstract: Robust sustained release formulations, solid dosage forms comprising robust sustained release formulations, and methods for making and using these formulations and solid dosage forms are provided. Robustness of the sustained release formulation is related to the particle size of the hydrophilic gum. Sustained release formulations resist dose-dumping when ingested with alcohol. The formulations are useful for treating a patient suffering from a condition, e.g., pain. The formulations comprise at least one drug. In one embodiment, the drug is an opioid, e.g., oxymorphone.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 10, 2008
    Applicant: Penwest Pharmaceuticals Co.
    Inventors: Anand R. Baichwal, Kevin Fitzmaurice, Steve Labudzinski
  • Publication number: 20080050434
    Abstract: Pharmaceutical composition for topical administration comprising of at least one active ingredient, its salts, esters, hydrates or derivatives; a gelator system consisting of a fiend of surfactants, a solvent system comprising at least one oily component; an aqueous phase; optionally containing one or more stabilizing agent; and other pharmaceutically acceptable excipients; and process for preparing such compositions are provided. Also provided is a method for the management/treatment of fungal, bacterial or microbial infections, inflammations, autoimmune conditions, or hormonal disorders which comprises administering a pharmaceutically effective amount of such pharmaceutical composition to a subject in need of such treatment. The compositions of the present invention are non-greasy and easily water washable, and provides an enhanced localization of hydrophobic and/or amphiphilic active ingredients on the skin.
    Type: Application
    Filed: March 17, 2005
    Publication date: February 28, 2008
    Inventors: Rajesh Jain, Kour Chand, Sukhjeet Singh, Vaibhav Sihorkar
  • Patent number: 7300669
    Abstract: A fluticasone lotion having improved vasoconstrictor and anti-inflammatory activity and higher than expected potency. The fluticasone lotion contains 0.05 weight percent fluticasone propionate and an oil-in-water vehicle that includes excipients. The fluticasone lotion is unexpectedly efficacious while exhibiting an improved safety profile.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: November 27, 2007
    Assignee: Altana Inc.
    Inventors: Gordon J. Dow, Keith Arthur Johnson, Frances Furr Kelly, Robert William Lathrop, Rukmini Rajagopalan
  • Patent number: 7297348
    Abstract: A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: November 20, 2007
    Assignees: Omeros Corporation, Institute of Materials Research and Engineering
    Inventors: Jun Li, Xu Li, Xiping Ni, Kam W. Leong
  • Patent number: 7297347
    Abstract: The invention provides polyanhydrides with aliphatic hydrocarbon terminals having ester or amide bonds.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: November 20, 2007
    Assignee: Efrat Biopolymers Ltd
    Inventor: Abraham J. Domb
  • Patent number: 7270834
    Abstract: A pharmaceutical composition to be externally applied as a topical preparation for treating several diseases, the composition comprising dimethylsulfoxide (DMSO) and ozone. A method for obtaining the composition by ozonizing DMSO and a method for treating diseases by applying the composition are also provided.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: September 18, 2007
    Inventors: Haydee Alba Stenti, Claudia Pirillo, Jose Maria Pastoriza
  • Patent number: 7267828
    Abstract: Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising hydrophilic, amphoteric and anionic polymers by subjecting the polymers to solutions containing an organic solvent and silver, during or after which one or more agents are added which facilitate the photostablization of the material.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 11, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: David Parsons, Elizabeth Jacques, Philip Bowler
  • Patent number: 7252838
    Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: August 7, 2007
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Marcia L. O'Conner, Michael S. Banik, Kathleen M. Miller
  • Patent number: 7229642
    Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: June 12, 2007
    Assignee: Scolr, Inc.
    Inventors: A. Reza Fassihi, Thomas Dürig
  • Patent number: 7208460
    Abstract: The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: April 24, 2007
    Assignee: Salvona IP, LLC
    Inventors: Adi Shefer, Samuel Shefer
  • Patent number: 7182957
    Abstract: A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: February 27, 2007
    Assignee: Macromed, Inc.
    Inventors: Gaylen M. Zentner, Jong-Seok Bark, Feng Liu
  • Patent number: 7169318
    Abstract: Solid composition has an organic spill absorbing material in which is absorbed certain of a liquid organic compound or composition. The organic spill absorbing material can be water insoluble, particulate polymer particles that imbibe liquid organic materials. A halogenated organic can provide the liquid organic compound or composition. The halogenated organic can be a halogenated hydrocarbon. A fire can be fought by transmitting the solid composition containing a suitable flame retardant to the base of the fire under conditions such that the absorbed liquid in liquid or vapor form is released; and a living target can be stupefied by transmitting the solid composition containing a suitable stupefying agent under conditions such that vapors of the stupefying agent are released and stupefy the target.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: January 30, 2007
    Inventor: Richard H. Hall
  • Patent number: 7160553
    Abstract: The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: January 9, 2007
    Assignee: Acrymed
    Inventors: Bruce L. Gibbins, Lance D. Hopman
  • Patent number: 7125570
    Abstract: An antibacterial composition is provided which comprises a base, an antibacterial agent consisting of a silver-supporting inorganic compound and a water-soluble salt of a nitrogen atom-containing 6-membered heterocyclic compound. In the antibacterial composition, the silver component susceptible to discoloration is effectively stabilized by the use of the water-soluble salt of a nitrogen atom-containing 6-membered heterocyclic compound and therefore, the antibacterial composition never or hardly undergoes any discoloration with the lapse of time.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 24, 2006
    Assignee: Sinanen Zeomic Co., Ltd.
    Inventors: Akio Taniguchi, Yasuo Kurihara, Masashi Uchida
  • Patent number: 7118761
    Abstract: Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogel, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: October 10, 2006
    Inventors: T. Andrew Canada, Robert L. Schuette, Raymond C. Sturm, Kenneth M. Wiencek, Jason L. Kreider
  • Patent number: 7112336
    Abstract: The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: September 26, 2006
    Assignee: Bayer HealthCare LLC
    Inventor: Francisco Cabrera
  • Patent number: 7101840
    Abstract: A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of the drug, the tissue-compatible polymer and the poly(alkylene oxide), after which the solution is added to a non-solvent for the drug, the tissue-compatible polymer and the poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of the drug, the tissue-compatible polymer and the poly(alkylene oxide) is formed, wherein the poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: September 5, 2006
    Assignee: Rutgers, The State University
    Inventors: Stephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
  • Patent number: 7090866
    Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (? receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: August 15, 2006
    Assignee: R.P. Scherer Technologies, Inc.
    Inventors: Edward Stewart Johnson, Jon Lacy
  • Patent number: 7078055
    Abstract: The present invention provides a method of attenuating swelling or inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent capable of absorbing water to a portion of the surface of the skin of the patient in an amount and at a location sufficient to attenuate swelling or inflammation.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: July 18, 2006
    Assignee: Ferris Pharmaceuticals Inc.
    Inventors: Robert W. Sessions, Alan R. Kahn
  • Patent number: 7078056
    Abstract: The present invention provides a method of attenuating the formation or reducing the severity of a bruise in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount and at a location sufficient to attenuate formation of or reduce the severity of bruising.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: July 18, 2006
    Assignee: Ferris Pharmaceuticals Inc.
    Inventors: Robert W. Sessions, Alan R. Kahn
  • Patent number: 7074431
    Abstract: A method for the preparation of compositions, preferably pharmaceutical compositions, in form of expanded, mechanically stable, lamellar, porous, sponge-like or foam structures out of solutions and dispersions results in a favored pharmaceutical product. This method comprises the steps of a) preparing a solution or a homogeneous dispersion of a liquid and a compound selected from the group consisting of one or more pharmaceutically active compounds, one or more pharmaceutically suitable excipients, and mixtures thereof, followed by b) the expansion of the solution or the homogeneous dispersion without boiling.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: July 11, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Busson, Marco Schroeder
  • Patent number: 7063863
    Abstract: A method for producing a drug system which is a reversible gelled matrix with entrapped drug. The gel is made by combining a polysaccharide, such as dextran, a polymer of glucose, with a natural macromolecule, such as the lectin, concanavalin A, with binding sites for monomers of the polysaccharide. The drug is released in response to exposure of the matrix to free carbohydrate containing the monomer of the polysaccharide for which the natural macromolecule binds.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: June 20, 2006
    Assignee: De Montfort University
    Inventor: Margaret Joan Taylor
  • Patent number: 7060299
    Abstract: Disclosed herein are biodegradable microparticle compositions, and methods for the generation of biodegradable and biocompatible microparticles that stabilize proteins and also control the kinetics of release of proteins over a period of several weeks to several months under physiological conditions.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: June 13, 2006
    Assignee: Battelle Memorial Institute
    Inventors: Sreedhara Alavattam, Richard S. Brody
  • Patent number: 7033606
    Abstract: The invention concerns a pharmaceutical composition designed to adhere to a mucous membrane for preventing or treating radiotherapy-related and chemotherapy-related mucositis, induced by radiotherapy or combined radiochemotherapy, comprising an effective amount of an antiradical compound mixed with a vehicle, which is liquid at room temperature and gels at the mucous membrane temperature and capable of adhering to the mucous membrane by its gelled status.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: April 25, 2006
    Assignee: Laboratoire L. Lafon
    Inventors: Jérôme Besse, Tam Nguyen, Joëlle Leyder
  • Patent number: 7030127
    Abstract: The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: April 18, 2006
    Assignee: Ethicon, Inc.
    Inventors: Aruna Nathan, Joel Rosenblatt, Steven C. Arnold
  • Patent number: 7030104
    Abstract: The present invention relates to the field of therapeutic chemistry and more especially to the realization of new galenic forms intended to be applied on the skin. More particularly it relates to a topical hormonal composition with a systemic effect for the hormonal treatment of the perimenopause and of the menopause as well as for the treatment of the ovarian hormonal deficiencies in women with amenorrhea, characterized in that it comprises, as active ingredients, a progestogen derived from 19-nor progesterone and estradiol or one of its derivatives, a vehicle which allows the systemic passage of said active ingredients, chosen from the group constituted by a solubilizing agent, an absorption promoting agent, a film-forming agent, a gelling agent and their mixtures, in combination or in a mixture with suitable excipients for the realization of a gelled and/or film-forming pharmaceutical form.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: April 18, 2006
    Assignee: Laboratoire Theramex
    Inventors: Georges Gray, Bertrand Villet, Jacques Paris, Jean-Louis Thomas
  • Patent number: 7014860
    Abstract: Production of a hyaluronic acid gel, which comprises keeping hyaluronic acid in water at a hyaluronic acid concentration of at least 5 wt % in the presence of an acid component in an amount at least equimolar with the carboxyl groups in the hyaluronic acid.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: March 21, 2006
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masatoshi Kawata, Akio Okamoto, Yoshiaki Miyata, Kazuhiro Ohshima, Osamu Yamamoto, Teruzou Miyoshi, Kazuhiko Arai, Hironoshin Kitagawa, Toshihiko Umeda, Hiroshi Kaneko
  • Patent number: 7005142
    Abstract: A veterinary delivery system in the form of a pliable film comprising at least one binder, at least one lubricant, at least one solvent for the binder and lubricant, and an effective amount of at least one effective agent. According to one embodiment, a flavorant is included in a pliable hydrophilic film in order to enhance oral acceptability by the animal. In other embodiments, the films preferably have a moisture content of about 2–15%, preferably about 3–7% by weight. The hydrophilic films most preferably have at least one effective agent distributed homogeneously throughout the film.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: February 28, 2006
    Inventors: Thomas Leon, John Berggren, Paul Gabel, Daniel S. Leon
  • Patent number: 6998426
    Abstract: These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1–C2 alkyl celluloses and their derivatives; C1–C3 alkyl guar; C1–C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: February 14, 2006
    Assignee: L'Oreal
    Inventors: Florence L'Alloret, Odile Aubrun-Sonneville, Jean-Thierry Simonnet
  • Patent number: 6977081
    Abstract: The present invention provides emollient creams composed of sulfur, sodium sulfacetamide and a botanically-derived anti-inflammatory ingredient. The creams are alcohol-free and have a pH at or above 7.0.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: December 20, 2005
    Assignee: Upsher-Smith Laboratories, Inc.
    Inventor: Gloria Rood
  • Patent number: 6967027
    Abstract: The invention concerns a colloidal dispersion, in an organic solvent, of a microfibrillated and/or microcrystalline particles of a fibrillated organic substance selected among the group consisting of cellulose, chitin, polysaccharides such as ?1?3 glucan, ?1?3 xylan and ?1?4 mannan, further containing a compound having a hydrophilic part and a hydrophobic part.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: November 22, 2005
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Laurent Heux, Celine Bonini
  • Patent number: 6939568
    Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 6, 2005
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin
  • Patent number: 6936275
    Abstract: Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: August 30, 2005
    Assignee: Scolr, Inc.
    Inventors: A. Reza Fassihi, Thomas Dürig
  • Patent number: 6932982
    Abstract: The invention relates to a granular delivery system based on a matrix combining at least a carbohydrate material with from 1 to 7% of prehydrated agar agar. The system disclosed is particularly stable in aqueous environments and is capable of providing the controlled release of an active flavoring or perfuming ingredient there-encapsulated.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: August 23, 2005
    Assignee: Firmenich SA
    Inventors: Robert C. McIver, Florin Vlad, Robert A. Golding, Jr., Travis D. Leichssenring, Daniel Benczedi
  • Patent number: 6921541
    Abstract: A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: July 26, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Mark Chasin, Paul Goldenheim, Richard Sackler, Joseph Tigner, Ronald M Burch
  • Patent number: 6913760
    Abstract: The invention provides a drug delivery compositions and methods for treating pain. A drug delivery composition contains a polymer and at least two drugs sucha as an analgesic agent and an anesthetic agent.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: July 5, 2005
    Assignee: New England Medical Hospitals, Inc.
    Inventors: Daniel B. Carr, Andrzej W. Lipkowski, Donald L. Wise, Vasif Hasirci
  • Patent number: 6902741
    Abstract: The transdermal system includes a sex hormone-containing adhesive matrix, which contains inclusions of a sex hormone in a hydrophilic non-crosslinked polymer in dissolved or dispersed form. The inclusions have a concentration of 20 to 90 percent by weight of the sex hormone, which is more than 50 percent by weight amorphous. The hydrophilic non-crosslinked polymer can be polyvinylpyrrolidone, methylcellulose, ethylcellulose or hydroxyethylcellulose. The adhesive matrix can be a polyisobutylene, ethylene-vinyl-acetate copolymer or a polystyrene-butadiene block copolymer.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: June 7, 2005
    Assignee: Jenapharm GmbH & Co. KG
    Inventors: Detlef Grawe, Peter Hoesel, Wilfried Fischer
  • Patent number: 6899897
    Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: May 31, 2005
    Assignee: Jaleva, Inc.
    Inventor: Alex Battaglia
  • Patent number: 6884434
    Abstract: A transdermal therapeutic system, comprising a backing layer inert to the components of the matrix, a self-adhesive matrix layer containing (?)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol in an effective amount and a protective foil or sheet to be removed prior to use, is characterised by a matrix that is based on a non-aqueous, acrylate-based or silicone-based polymer adhesive system having a solubility of ?5% (w/w) for (?)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]-amino]-1-naphthalenol, and said matrix is substantially free of inorganic silicate particulates.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: April 26, 2005
    Assignees: LTS Lohmann Therapie-Systeme AG, Aderis Pharmaceuticals, Inc.
    Inventors: Walter Muller, James V. Peck
  • Patent number: 6878384
    Abstract: Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: April 12, 2005
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Michael J. Constant
  • Patent number: 6869612
    Abstract: A purified shilajit composition is provided herein from native shilajit. The composition has an abundance of bioactive components, particularly, at least 0.3%, preferably 0.4-1%, by weight, oxygenated dibenzo-?-pyrones and at least 60%, preferably 65-70%, by weight of fulvic acids of low-to-medium molecular weight ({overscore (M)}n of 700-2000) with an E4/E6 ratio of 8-10 at ?465-665 nm, and whose 2% aqueous solution has a pH of ?7. Personal care, pharmaceutical and nutritional use formulations of the purified shilajit composition also are described.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: March 22, 2005
    Assignees: Natreon, Inc., Indian Herbs Research & Supply Company Ltd.
    Inventor: Shibnath Ghosal
  • Patent number: 6852329
    Abstract: An effective, readily ingested molluscicidal bait poison includes a mollusc bait and a second component. The second component can contain a transition metal compound and a complexing agent, and/or the complex of a transition metal compound and a complexing agent. The complexing agent is preferably iminodisuccinic acid (IDS), including sodium IDS (IDS Na-Salt), iminodifumaric acid (IDF), iminoditartaric acid (IDT), iminodimaleic acid (IDMAL), ethylenediaminedifumaric acid (EDDF), ethylenediaminedimalic acid (EDDM), iminodimalic acid (IDM), ethylenediamineditartaric acid (EDDT), ethylenediaminedimaleic acid (EDDMAL), and salts thereof.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 8, 2005
    Assignee: W. Neudorff GmbH KG
    Inventors: George S. Puritch, Andreas Prokop, David S. Almond, Robert Matson
  • Patent number: 6844005
    Abstract: The present invention relates to a nasal topical application product for restricting the flow of airborne contaminants into a human nasal passage by creation of a proximate, enhanced electrostatic field. This nasal application product includes: (a) a plurality of masses of one or more electrostatic polymers; and, (b) a topical carrier having the plurality of masses dispersed through a portion thereof. At least one of the electrostatic polymers is a poly (dimethyl diallyl ammonium chloride) polymer and is included in the product in an amount of at least 10% by weight, based on the total weight of the polymers and the topical carrier. The nasal application product may be topical solutions, semisolids, spray solutions and vaporizable solutions. Topical applications may be in the form of ointments, pastes, creams and gels. The carrier of the nasal application product of the present invention may be selected from the group consisting of dilutents, volatile spray carriers, lotions, solvents, gels and hydrogels.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: January 18, 2005
    Assignee: Trutek Corp
    Inventors: Ashok L. Wahi, Kanneth Sugathan
  • Patent number: 6843986
    Abstract: An attractant composition for application to fishing lures is composed of about 10-45% bees wax and up to about 75 % menhaden oil.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: January 18, 2005
    Inventor: Stephen L. McMaster
  • Patent number: 6835386
    Abstract: The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel formulation comprising a fatty acid, an organic solvent which is a linear aliphatic ester, a silicone-based fluid, or a combination thereof, and an active ingredient that can protect the animal against one or more arthropod pests.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: December 28, 2004
    Assignee: Pfizer Inc.
    Inventor: Luis Gutierrez
  • Patent number: 6800301
    Abstract: The invention is a user friendly, multi-purpose ointment whose simple basic formula is a combination of karaya gum powder and a vehicle for dispersing, such as petrolatum. It can be designed to treat a variety of skin problems by adding some non-essential ingredients such as Vitamin A&D Ointment, Vitamin E cream or Lotion at the discretion of the user, in addition to various pharmaceuticals based on the cause of the problem such as an antibacterial, an antifungal, an anti-inflammatory agent, an antiviral, an anti-parasitic, or an enzymatic agent at the discretion of the health care provider or user.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: October 5, 2004
    Inventor: Sadie N. Smith
  • Patent number: 6797283
    Abstract: The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use. The active agent dosage form is a multilayer core, often bilayer, formed of polymer matrices that swell upon contact with the fluids of the stomach. At least one layer of the multilayered dosage form includes an active agent. A portion of the polymer matrices are surrounded by a band of insoluble material that prevents the covered portion of the polymer matrices from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: September 28, 2004
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Francisco Jao, Patrick S. -L. Wong
  • Patent number: 6790453
    Abstract: Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by: (i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and (ii) extruding the melted mixture, to obtain an extruded mixture.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: September 14, 2004
    Assignee: McCormick & Company, Inc.
    Inventors: Michael A. Porzio, Dmitriy Zasypkin
  • Patent number: 6787529
    Abstract: The present invention relates to a pharmaceutical gel composition for application on skin, said composition comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid as well as a viscosity-increasing excipient.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: September 7, 2004
    Assignee: Leo Pharmaceutical Products Ltd. A/S
    Inventors: Gert Høy, Erik Johannes Didriksen