Polysaccharides (e.g., Cellulose, Etc.) Patents (Class 424/488)
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Patent number: 8758729Abstract: The invention describes the modification of polyamine-based materials to form polyguanidine compounds that are useful for their antimicrobial, anticaries, and muccoadhesive properties. The present invention also relates to methods for preventing or treating periodontal disease and caries which include delivering a therapeutically effective amount of an oral composition containing a polyguanidine compound into an oral cavity.Type: GrantFiled: May 18, 2009Date of Patent: June 24, 2014Assignee: Colgate-Palmolive CompanyInventors: Andrew Nowak, Shira Pilch, Jim Masters
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Patent number: 8758819Abstract: A cosmetic composition comprising at least one compound selected from bioactive/biocompatible microparticulates such as bioactive glass or bioactive ceramics, and an intradermal delivery vehicle selected from the group consisting of hyaluronans, hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid in an amount sufficient to facilitate deposition and penetration of said bioactive microparticulates through tissue at a site to be treated.Type: GrantFiled: September 7, 2007Date of Patent: June 24, 2014Assignee: Enhance Skin Products, Inc.Inventor: Samuel Asculai
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Publication number: 20140170219Abstract: Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.Type: ApplicationFiled: July 13, 2012Publication date: June 19, 2014Applicants: UNIVERSITE LIBRE DE BRUXELLES, FEMALON S.P.R.L.Inventors: Marie Piette, Brigitte Evrard, Isabelle Coïaée
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Patent number: 8753705Abstract: Mineral-bound starch products are provided for enhanced absorption of nutrient minerals. The mineral-bound starch products are prepared by binding biologically active minerals to phosphorylated cross-linked starch. The mineral-bound starch products are stable against heating in hot water followed by washing processes, but able to release bound minerals after digestion.Type: GrantFiled: June 7, 2005Date of Patent: June 17, 2014Assignee: MGPI Processing, Inc.Inventors: Kyungsoo Woo, Sukh D. Bassi, Clodualdo C. Maningat, Girish M. Ganjyal, Lianfu Zhao
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Patent number: 8747893Abstract: The present invention is to obtain capsules which do not disintegrate in stomach and intestine after orally administrating them and which disintegrate specifically in large intestine. The present invention thus provides a capsule which disintegrates specifically in large intestine, comprising a content comprising a main agent, and a shell, covering the content, comprising a natural water-soluble polymer as a shell base material and chitosan powder dispersing in the natural water-soluble polymer.Type: GrantFiled: October 16, 2012Date of Patent: June 10, 2014Assignee: Morishita Jintan Co., Ltd.Inventors: Ryosei Kamaguchi, Masafumi Mizutani
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Patent number: 8748476Abstract: The invention provides the use of darifenacin, or a pharmaceutically acceptable derivative thereof, in the manufacture of a medicament for the reduction of urgency in patients suffering from overactive bladder.Type: GrantFiled: March 4, 2009Date of Patent: June 10, 2014Assignee: Warner Chilcott Company, LLCInventors: Enrico Colli, Paul Quinn, Dzelal Serdarevic, Larence Howard Skillern
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Patent number: 8741269Abstract: The invention encompasses non-aqueous dentifrice compositions containing a bioacceptable and bioactive glass with improved mouth-feel, foam, and product stability. More particularly, the invention encompasses non-aqueous compositions including combinations including carrageenan and/or carboxymethylcellulose gums, glycerin, ethylene oxide/propylene oxide copolymers, and a bioactive glass and methods of use the compositions in an oral care product, for example, a whitening tooth-paste, for hypersensitive teeth.Type: GrantFiled: April 1, 2010Date of Patent: June 3, 2014Assignee: Colgate-Palmolive CompanyInventors: Prakasarao Mandadi, Suman K. Chopra, Lynette Zaidel, Michael Prencipe
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Patent number: 8741645Abstract: The present invention provides a method for performing a biological test under conditions in which an artificially prepared cell pattern with initial position coordinates that can be determined is three-dimensionally cultured within a gelled matrix. The present invention relates to a biological test method that comprises testing a biological indicator with reference to at least one selected from the group consisting of cell proliferation, cell movement, and cell differentiation in a cell pattern substantially embedded in gel. The present invention also relates to a kit for the biological test method.Type: GrantFiled: April 22, 2011Date of Patent: June 3, 2014Assignee: Dai Nippon Printing Co., Ltd.Inventors: Hideshi Hattori, Norihiko Okochi, Masatoshi Kuroda, Masahiko Hase
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Patent number: 8741347Abstract: The present invention relates to a method for preparing a cyclodextrin polymer and/or a hydrophilic polymer emulsion having cyclodextrins as well as lipophilic compounds, the emulsions having a remarkable stability. In particular, the method includes: (i) adding a lipophilic compound into an aqueous solution of a cyclodextrin unit polymer or hydrophilic polymer having cyclodextrins; (ii) forming an emulsion from the mixture resulting from step (i). The invention also relates to the resulting emulsions, i.e. stabilized emulsions by a non-covalent and non-crystalline inclusion complex consisting of (i) a cyclodextrin unit polymer or a hydrophilic polymer having cyclodextrins and (ii) a lipophilic compound. The invention also relates to the use of said emulsions in the cosmetic, pharmaceutical and/or agri-food fields.Type: GrantFiled: April 23, 2010Date of Patent: June 3, 2014Assignees: Centre National de la Recherche Scientifique—CNRS, Universite Paris—SUD 11Inventors: Anca-Lucia Laza-Knoerr, Ruxandra Gref, Catherine Amiel, Patrick Couvreur
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Patent number: 8741346Abstract: The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterized in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.Type: GrantFiled: April 23, 2004Date of Patent: June 3, 2014Assignee: Pierre Fabre MedicamentInventors: Hubert Lochard, Martial Sauceau, Bernard Freiss
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Patent number: 8741331Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.Type: GrantFiled: June 12, 2013Date of Patent: June 3, 2014Assignees: A. V. Topchiev Institute of Petrochemicals Synthesis, Russian Academy of Sciences, Corium International, Inc.Inventors: Parminder Singh, Adrian Faasse, Gary W. Cleary, Sri Mudumba, Mikhail M. Feldstein, Danir F. Bairamov
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Patent number: 8728524Abstract: New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.Type: GrantFiled: May 10, 2012Date of Patent: May 20, 2014Assignee: Anika Therapeutics S.R.L.Inventors: Davide Bellini, Cristina Longinotti, Vittorio Crescenzi, Anna Taglienti
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Patent number: 8728499Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.Type: GrantFiled: June 4, 2013Date of Patent: May 20, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Scott Zawko, Christine Schmidt
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Patent number: 8728504Abstract: A process for solubilizing hydrophobic active ingredients in aqueous medium, which comprises using, as an assistant, at least one hyperbranched polymer (A) which is obtainable by reacting at least one hyperbranched polymeric compound having at least one primary or secondary amino group per molecule (a), selected from (a1) hyperbranched polyamides and (a2) hyperbranched polyureas, with (b) at least one mono-, di- or oligosaccharide.Type: GrantFiled: February 4, 2011Date of Patent: May 20, 2014Assignee: BASF SEInventors: Bernd Bruchmann, Holger Türk, Daniel Schönfelder, Monika Haberecht, Dietmar Appelhans, Victor Boyko
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Publication number: 20140134250Abstract: The invention pertains to a method of relieving pain by administering a controlled release pharmaceutical tablet containing oxymorphone which produces a mean minimum blood plasma level 12 to 24 hours after dosing, as well as the tablet producing the sustained pain relief.Type: ApplicationFiled: June 3, 2013Publication date: May 15, 2014Inventors: Huai-Hung Kao, Anand R. Baichwal, Troy McCall, David Lee
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Patent number: 8722749Abstract: A method for producing foams, such as sponges, from hydrocolloids is described. A solid or semi-solid gel is formed by dissolving polymeric material in an aqueous solvent. The gel formed is allowed to set, and may optionally then be cut into the desired shape. The gel may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the gel is exposed to a radiant energy field for drying under vacuum. This causes the solvent to boil and the foam or sponge is formed. Medicinally active ingredients may be included in the process, so that the sponge or foam formed contains the active ingredient dispersed within the structure. The method described provides an alternative to the conventional methods of particulate leaching or freeze drying.Type: GrantFiled: July 29, 2005Date of Patent: May 13, 2014Assignee: Enwave CorporationInventors: Timothy D. Durance, Jaya Sundaram, Mareike Ressing
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Patent number: 8722066Abstract: The present invention provides, compositions, devices, and methods for affecting, among other things, weight loss and/or weight control, by sequestering nutrients or other compounds such as toxins from absorption in the digestive tract. The compositions, devices, and methods employ one or more members made of a compressible, absorbent matrix material. In various embodiments, the matrix material is suitable for routine use. The compressible absorbent matrix material has a size, shape and/or geometry configured for efficient packing into a small space, and/or configured to absorb and substantially retain digested material in the stomach. The devices and compositions may further comprise one or more hydrogel(s), soluble or insoluble fibers, waxes and/or gums to provide the desired mechanical properties and/or absorptive or shielding properties.Type: GrantFiled: March 27, 2012Date of Patent: May 13, 2014Assignee: Primigenia, LLCInventor: Paolo Costa
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Publication number: 20140127292Abstract: Oral pharmaceutical compositions for the controlled release of heparin or derivatives thereof, for example dalteparin, salts and/or derivatives thereof, comprising (a) a matrix consisting of amphiphilic compounds and lipophilic compounds with melting point lower than 90° C. in which the active ingredient is at least partially dispersed; (b) an outer hydrophilic matrix in which the lipophilic/amphiphilic matrix is dispersed; (c) optionally, other excipients suitable for solid pharmaceutical forms. The treatment of inflammatory bowel diseases (IBD) by administering to a patient in need thereof an effective amount of dalteparin, salts and/or derivatives thereof is also disclosed.Type: ApplicationFiled: December 30, 2013Publication date: May 8, 2014Applicant: Cosmo Technologies LimitedInventors: Mauro Ajani, Luigi Moro, Roberto Villa
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Patent number: 8716213Abstract: A structured liquid detergent composition in the form of a liquid matrix made up of an external structuring system of a bacterial cellulose network; water; and surfactant system including an anionic surfactant; a nonionic surfactant; a cationic surfactant; an ampholytic surfactant; a zwitterionic surfactant; or mixtures thereof, wherein said liquid matrix has a yield stress of from about 0.003 Pa to about 5.0 Pa at about 25° C. and provides suitable particle suspension capabilities and shear thinning characteristics.Type: GrantFiled: June 29, 2011Date of Patent: May 6, 2014Assignee: The Procter & Gamble CompanyInventors: Marco Caggioni, Rafael Ortiz, Freddy Arthur Barnabas, Raul Victorino Nunes, Janine A. Flood, Francesc Corominas
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Patent number: 8715719Abstract: A method of preparing a stable chitosan hemostatic implant including preparing a lyophilizable solution of chitosan polymers and freezing the solution to obtain a frozen chitosan composition. The method further includes placing the frozen chitosan composition under vacuum so as to substantially dry the chitosan composition and curing the dried chitosan composition by first exposing it to a relative humidity and then curing the dried chitosan composition under heat so as to crosslink the chitosan polymers.Type: GrantFiled: June 16, 2010Date of Patent: May 6, 2014Assignee: Abbott Vascular, Inc.Inventors: Wouter E. Roorda, Jill A. McCoy, Richard Seto, Eugene T. Michal
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Patent number: 8715733Abstract: An enhanced adipose tissue containing native adipose tissue and a concentrated amount of an active agent derived from adipose tissue, wherein the enhanced adipose tissue is preferably injected into the intervertebral disc of a patient suffering from degenerative disc disease.Type: GrantFiled: July 26, 2005Date of Patent: May 6, 2014Assignee: DePuy Synthes Products, LLCInventors: Sudhakar Kadiyala, Mohamed Attawia, Thomas M DiMauro
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Publication number: 20140112980Abstract: An abuse-resistant controlled release pharmaceutical composition comprising a pharmaceutically effective amount of discrete particles of an active capable of abuse, wherein surfaces of said particles are wetted with a water insoluble coating material, and preferably wherein said composition comprises a matrix, in which said particles are distributed, and which renders the abuse-capable compound within the matrix difficult to separate from the matrix; and a method for the preparation of a controlled release pharmaceutical composition having a reduced potential for abuse, comprising applying a pressure force to a mixture comprising a water insoluble material, and particles of a pharmaceutically active compound capable of inducing in a subject a reaction that is physiologically or psychologically detrimental if administered in an immediate release dosage form, thereby resulting in surface coated particles, and incorporating said surface coated particles into a pharmaceutical compositionType: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Inventors: Farid Vaghefi, Gary G. Liversidge, Stephen B. Ruddy, Eugene R. Cooper
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Patent number: 8703199Abstract: Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.Type: GrantFiled: December 4, 2006Date of Patent: April 22, 2014Assignee: Bend Research, Inc.Inventors: Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey, Ralph Tadday
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Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof
Patent number: 8703198Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.Type: GrantFiled: March 1, 2006Date of Patent: April 22, 2014Assignee: Aquatrove BiosciencesInventors: Vibha Gupta, Boris Nikolic, Vineet Gupta -
Patent number: 8703924Abstract: This invention relates to a cross-linkable chitosan composition comprising chitosan having a degree of deacetylation between 30 and 75%, wherein the chitosan is randomly deacetylated, and a cross-linking agent, wherein the molar ratio of the cross-linking agent to chitosan is 0.2:1 or less based on the number of functional groups in the cross-linking agent and the number of accessible amino groups in the chitosan. The invention also provides a chitosan hydrogel formed therefrom and uses thereof.Type: GrantFiled: October 30, 2008Date of Patent: April 22, 2014Assignee: Viscogel, ABInventor: Mats Andersson
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Patent number: 8703691Abstract: A structured liquid detergent composition in the form of a liquid matrix made up of an external structuring system of a bacterial cellulose network; water; and surfactant system including an anionic surfactant; a nonionic surfactant; a cationic surfactant; an ampholytic surfactant; a zwitterionic surfactant; or mixtures thereof, wherein said liquid matrix has a yield stress of from about 0.003 Pa to about 5.0 Pa at about 25° C. and provides suitable particle suspension capabilities and shear thinning characteristics.Type: GrantFiled: March 7, 2012Date of Patent: April 22, 2014Assignee: The Procter & Gamble CompanyInventors: Marco Caggioni, Rafael Ortiz, Freddy Arthur Barnabas, Raul Victorino Nunes, Janine A. Flood, Francese Corominas
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Patent number: 8703171Abstract: The present invention relates to a method of easing childbirth using a composition having a lubricant effect for use in particular during human vaginal delivery. The methods comprise applying a bioadhesive composition comprising (a) a polyacrylic acid, (b) a water-soluble thickener and (c) a humectant and (d) optionally water.Type: GrantFiled: November 10, 2005Date of Patent: April 22, 2014Assignee: HCB Happy Child Birth Holding AGInventor: Andreas F. Schaub
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Patent number: 8697125Abstract: The present invention provides a tablet without causing a tableting trouble, which is superior in the tablet formability, dissolution property of pharmaceutically active ingredient, and the like.Type: GrantFiled: January 30, 2008Date of Patent: April 15, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Akihiko Ono, Shigeyuki Marunaka, Makoto Fukuta
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Patent number: 8697105Abstract: The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the formulation is substantially free of water. The invention also provides a drug delivery depot formed from the injectable formulation wherein the polymers crosslink in the presence of water in the body of a patient, or in the air, prior to implantation in the patient. Also provided are methods of treatment using such formulations and drug delivery systems.Type: GrantFiled: March 29, 2011Date of Patent: April 15, 2014Assignee: SurModics, Inc.Inventor: Joram Slager
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Patent number: 8697746Abstract: A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.Type: GrantFiled: July 13, 2011Date of Patent: April 15, 2014Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Andrew Xian Chen, John Fan, Masazumi Yamaguchi
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Patent number: 8697643Abstract: A conjugate that includes a drug covalently linked to a polymer. Upon administration, the conjugate is digested by an enzyme that is present at the site of administration thereby releasing a therapeutic agent. The conjugate may demonstrate substantially the same pharmacokinetic and pharmacodynamic behavior as the drug itself. A material for controllably releasing a conjugate in response to the local concentration of a molecular indicator. The material includes a plurality of conjugates and a plurality of multivalent cross-linking agents. The polymers of the conjugates include an analog of the indicator within their covalent structure. The multivalent cross-linking agents include cross-link receptors that interact with the indicator analog and thereby cross-link the conjugates.Type: GrantFiled: February 6, 2012Date of Patent: April 15, 2014Assignee: SmartCells, Inc.Inventors: Thomas M. Lancaster, Matthew Nalewanski, Todd C. Zion
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Patent number: 8691973Abstract: Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.Type: GrantFiled: February 21, 2007Date of Patent: April 8, 2014Assignee: Korea Institute of Radiological & Medical SciencesInventors: Chun-Ho Kim, Seung-Jae Lee, Jin-Ik Lim, Youngsook Son
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Patent number: 8691279Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.Type: GrantFiled: March 21, 2011Date of Patent: April 8, 2014Assignee: Allergan, Inc.Inventors: Karina H. Guillen, Ahmet Tezel
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Patent number: 8685454Abstract: A lubricating composition prepared primarily from organic materials (primarily plants and micro-organisms). The unique process and mixture of organic materials comprising this lotion provide with superior properties for various uses. The lotion exists as a viscous liquid with mucosa moistening properties. Some suggested applications for the lotion are that it may be used as a means for delivering medication, skin moisturizing and to enhances sexual experiences.Type: GrantFiled: September 4, 2007Date of Patent: April 1, 2014Assignee: Yes Syzygy LimitedInventor: Sarah Annabelle Brooks
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Publication number: 20140086988Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein crystals, formulations and compositions comprising them. Provided are methods and compositions for encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery.Type: ApplicationFiled: September 9, 2013Publication date: March 27, 2014Applicant: Althea Technologies, Inc.Inventors: Alexey L. MARGOLIN, Nazar K. KHALAF, Nancy L. ST. CLAIR, Scott L. RAKESTRAW, Bhami C. SHENOY
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Patent number: 8679540Abstract: The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles, and to the applications, especially therapeutic applications, of these formulations. Formulations may include an aqueous colloidal suspension of low viscosity based on micrometric particles of a water-soluble, biodegradable, amphiphilic polymer carrying hydrophobic groups and ionizable hydrophilic groups that are at least partially ionized, said particles being capable of associating spontaneously and non-covalently with an active principle, at pH=7.0, under isotonic conditions. This suspension contains multivalent ions of opposite polarity to that of the hydrophilic groups, the ratio r, defined by the formula r=n×([IM]/[GI]), where n is the valency of said multivalent ions, [IM] is the molar concentration of multivalent ions, [GI] is the molar concentration of ionizable groups GI, being between 0.3 and 10.Type: GrantFiled: June 11, 2007Date of Patent: March 25, 2014Assignee: Flamel TechnologiesInventors: Cécile Bonnet-Gonnet, David Chognot, Olivier Soula, Alain Constancis
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Patent number: 8679535Abstract: Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a sustained release matrix comprising a gelling agent, said gelling agent comprising a heteropolysaccharide gum and a homopolysaccharide gum capable of cross-linking said heteropolysaccharide gum when exposed to an environmental fluid, said dosage form providing a sustained release of said medicament after oral administration to human patients.Type: GrantFiled: March 27, 2007Date of Patent: March 25, 2014Assignee: Endo Pharmaceuticals Inc.Inventors: Anand R. Baichwal, Troy W. McCall, Lirong Liu, Steve Labudzinski
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Patent number: 8679523Abstract: The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.Type: GrantFiled: December 29, 2000Date of Patent: March 25, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Bruce L. Gibbins, Lance D. Hopman
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Patent number: 8679537Abstract: Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.Type: GrantFiled: August 24, 2006Date of Patent: March 25, 2014Assignee: Actamaz Surgical Materials, LLCInventor: Samuel David Arthur
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Patent number: 8679536Abstract: Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.Type: GrantFiled: August 24, 2006Date of Patent: March 25, 2014Assignee: Actamax Surgical Materials, LLCInventor: Samuel David Arthur
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Patent number: 8673294Abstract: An immunoisolation patch system, and particularly a patch system comprising multiple immunoisolation microcapsules, each encapsulating biological material such as cells for transplantation, which can be used in the prophylactic and therapeutic treatment of disease in large animals and humans without the need for immunosuppression.Type: GrantFiled: April 23, 2009Date of Patent: March 18, 2014Assignee: Vanderbilt UniversityInventor: Taylor G. Wang
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Publication number: 20140072629Abstract: Described herein are methods and compositions related to biologic matrices comprising at least one anti-infective. In certain embodiments, the invention relates to a biologic matrix comprising a slowed release anti-infective agent. In a particular embodiment, the invention relates to an acellular dermal matrix comprising a slowed release anti-infective agent, wherein the anti-infective agent is triclosan. In further embodiments, the invention relates to a biologic matrix comprising at least one anti-infective agent, wherein the biologic matrix is suitable for use in surgical procedures, such as, for example, for the replacement of damaged or inadequate integumental tissue or for the repair, reinforcement or supplemental support of soft tissue defects.Type: ApplicationFiled: August 7, 2013Publication date: March 13, 2014Inventors: Carl Alexander DePaula, Arthur A. Getzman, Moon Hae Suwoon
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Patent number: 8663690Abstract: Methods of nanoencapsulation are described herein. Embodiments of the method utilize the coacervation of a cationic polyelectrolyte with an anionic polyelectrolyte to form a novel capsular matrix. In particular, the novel methods may be used to encapsulate a suspension of a hydrophobic material such as a carotenoid. The disclosed methods do not require lengthy pH adjustments nor do they require the use of any toxic crosslinking agents. In one embodiment, a method of encapsulation comprises dispersing a hydrophobic compound in an organic solvent to form a solution. The method also comprises admixing an anionic polyelectrolyte and a cationic polyelectrolyte with the suspension to form a mixture. In addition, the method comprises quiescently cooling the mixture so as to cause self-crosslinking of a capsular matrix encapsulating the hydrophobic particles.Type: GrantFiled: October 31, 2006Date of Patent: March 4, 2014Assignee: William Marsh Rice UniversityInventors: Muhammed K. Gheith, Yu-Lun Fang, Michael S. Wong
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Patent number: 8663691Abstract: Provided are a gel composition for a shower filter with viscosity restorability, a method for manufacturing a shower gel filter and a shower filter. More particularly, the gel composition for a shower filter includes dextrin, a fragrance, water and a water-soluble cellulose ether, and may further include vitamin C intended to remove residual chlorine and harmful substances contained in water, and a food coloring intended to allow the users to identify a particular type of fragrance.Type: GrantFiled: July 7, 2010Date of Patent: March 4, 2014Inventor: Ji-hang Jeong
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Patent number: 8663686Abstract: The present invention provides compositions comprising an interpolymer of chitosan and polyethylene glycol, wherein the interpolymer is a liquid below 25° C. and a gel above 35° C. The present invention also provides methods for using the compositions to deliver drugs to a living body over time.Type: GrantFiled: May 9, 2005Date of Patent: March 4, 2014Assignee: University of WashingtonInventors: Miqin Zhang, Narayan Bhattarai, Frederick A. Matsen
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Patent number: 8658207Abstract: The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of flibanserin and at least one pharmaceutically acceptable excipient, characterized in that said pharmaceutical release systems exhibit a pharmacokinetic profile that is characterized by an average maximum flibanserin plasma concentration Cmax lower than 300 ng/mL, preferably lower than 200 ng/mL after administration of a single dose to healthy volunteers in fasted state or directly after a meal.Type: GrantFiled: August 13, 2007Date of Patent: February 25, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Wolfram Eisenreich, Thomas Friedl, Florian Sommer, Nantharat Pearnchob, Karl G. Wagner
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Patent number: 8652522Abstract: It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.Type: GrantFiled: July 28, 2010Date of Patent: February 18, 2014Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Akihiro Hasui, Takamitsu Miyagi
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Patent number: 8653029Abstract: The present invention provides a composition that may be used as an implant or a bone graft substitute or extender for filling voids and/or promoting fusion of osseous tissues. The implant may comprise ceramic granules such as calcium phosphate granules and one or more polysaccharide excipients, and may be in the form of a putty or flowable paste. Optionally, the implant may also comprise a growth factor such as a bone morphogenetic protein.Type: GrantFiled: July 30, 2009Date of Patent: February 18, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Scott Mitchell Vickers, Jeffrey L. Scifert
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Publication number: 20140044780Abstract: Described herein is a pharmaceutical composition comprising levetiracetam as an active ingredient to provide prolonged release characteristic to allow once a day dosage regime. The innovative formulation comprises levetiracetam and a hydrophobic polymer with or without additional release rate modifier(s). The formulation may comprise other pharmaceutically acceptable excipients. This invention also describes the processes of preparing such dosage forms.Type: ApplicationFiled: August 5, 2013Publication date: February 13, 2014Inventors: I-Lan Tung Sue, Jung-Chung Lee
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Publication number: 20140037731Abstract: A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis.Type: ApplicationFiled: November 24, 2008Publication date: February 6, 2014Inventors: George John, Praveen Kumar Vemula