Adipose Or Epithelium Patents (Class 424/574)
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Patent number: 8518396Abstract: The present invention is directed to compositions and methods of transplanting tissue, for example, in breast augmentation procedures. The compositions include adipose tissue and compounds that reduce tissue volume loss and increase survival rate of the adipose tissue when the composition is introduced into breast tissue.Type: GrantFiled: June 25, 2012Date of Patent: August 27, 2013Assignee: Allergan, Inc.Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
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Publication number: 20130202563Abstract: Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.Type: ApplicationFiled: December 20, 2010Publication date: August 8, 2013Applicant: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Stephen F. Badylak, Bryan N. Brown, John M. Freund, J. Peter Rubin
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Publication number: 20130164383Abstract: The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.Type: ApplicationFiled: October 11, 2011Publication date: June 27, 2013Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Koichi Masuda, Mitsuru Naiki
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Patent number: 8460714Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: April 3, 2012Date of Patent: June 11, 2013Assignee: TissueTech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Publication number: 20130142844Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.Type: ApplicationFiled: January 30, 2013Publication date: June 6, 2013Applicant: CRYOLIFE, INC.Inventor: CRYOLIFE, INC.
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Patent number: 8455009Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: April 23, 2012Date of Patent: June 4, 2013Assignee: TissueTech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Publication number: 20130129835Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.Type: ApplicationFiled: January 14, 2013Publication date: May 23, 2013Applicant: ALLERGAN, INC.Inventor: ALLERGAN, INC.
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Publication number: 20130122109Abstract: Disclosed in the present invention are a formula and preparation method for a hair-regrowth preparation, the preparation containing extracts of fresh ginger, huangqi (Radix astragali), heshouwu (Polygonum multiflorum), black ants, danggui (Angelica sinensis), lianzicao (Alternanthera philoxeroides), chuanqiong (Ligusticum chuanxiong), danshen (Salvia miltiorrhiza), dodder seed, almonds, black beans, walnuts, qingxiangzi (Semen celosiae), digupi (Chinese Wolfberry Root-bark), hanliancao (Eclipta prostrata), mulberry fruit, black-bone chicken and duck fat, and also containing 65% ethanol solution and 40% ethanol solution, the whole being variously subjected to techniques of mixing, grinding, maceration and extraction to produce a thick-ointment composition.Type: ApplicationFiled: October 26, 2011Publication date: May 16, 2013Inventor: Zhiyuan Tian
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Patent number: 8440235Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: April 23, 2012Date of Patent: May 14, 2013Assignee: TissueTech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8420126Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: April 23, 2012Date of Patent: April 16, 2013Assignee: Tissue Tech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8409625Abstract: The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. The composition is conditioned by culturing cells on the matrix and/or by exposing the cultured cells or matrix to one or more stressors.Type: GrantFiled: January 9, 2009Date of Patent: April 2, 2013Assignee: ACell, Inc.Inventor: Stephen F. Badylak
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Publication number: 20130071360Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.Type: ApplicationFiled: June 28, 2012Publication date: March 21, 2013Applicant: BIORESTORATIVE THERAPIES, INC.Inventors: Francisco Silva, Mark Weinreb, Amit N. Patel, David A. Bull
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Publication number: 20130071486Abstract: The invention provides acellular tissue matrices made from collagen-containing tissues of animals genetically modified so as to be deficient in the galactose 1,3-galactose epitope and methods of making and using such acellular tissue matrices.Type: ApplicationFiled: November 16, 2012Publication date: March 21, 2013Applicant: LifeCell CorporationInventor: LifeCell Corporation
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Publication number: 20130045267Abstract: Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin-1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same.Type: ApplicationFiled: February 7, 2011Publication date: February 21, 2013Applicant: UNIVERSITY OF ROCHESTERInventors: Lisa A. Beck, Anna De Benedetto
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Publication number: 20130028981Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.Type: ApplicationFiled: February 25, 2011Publication date: January 31, 2013Applicant: DECELL TECHNOLOGIES INC.Inventor: Paul F. Gratzer
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Patent number: 8337902Abstract: Methods for the degradation of prion proteins are described. Items that may be contaminated with prions are treated with earthworm-derived extracts to degrade prion proteins and reduce their infectivity in animals. Methods of using an earthworm-derived protein extract for treating foodstuffs and surfaces to inhibit or disable prion infectivity are disclosed. Also disclosed are methods for treating medical instruments, tools used to butcher animals, and laboratory equipment.Type: GrantFiled: September 24, 2009Date of Patent: December 25, 2012Assignee: Wisconsin Alumni Research FoundationInventors: Judd M. Aiken, Jay R. Schneider
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Patent number: 8313743Abstract: The present invention encompasses methods and compositions for treating a bone condition. The isolated adipose tissue-derived stromal cell of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications such as in spinal fusion procedures.Type: GrantFiled: June 1, 2010Date of Patent: November 20, 2012Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jeffrey M. Gimble, Mandi Lopez
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Patent number: 8298586Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.Type: GrantFiled: July 22, 2009Date of Patent: October 30, 2012Assignee: Acell IncInventors: Rodney W. Bosley, Jr., Clay Fette
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Patent number: 8293280Abstract: A method for treatment of HIV infection includes administering at least one anti-HIV drug, such as a reverse transcriptase inhibitor, to a patient in need of such treatment and administering an extract from inflammatory tissue inoculated with vaccinia virus to the patient following the administration of the at least one anti-HIV drug. The extract maintains suppressive action on HIV replication, even if the administration of the anti-HIV drug is terminated.Type: GrantFiled: December 15, 2005Date of Patent: October 23, 2012Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Aftab A. Ansari, M. Eric Gershwin
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Publication number: 20120263763Abstract: Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.Type: ApplicationFiled: April 13, 2012Publication date: October 18, 2012Inventors: Wenquan Sun, Melissa Richter Bowley, Raghav Goel
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Publication number: 20120265072Abstract: The method includes novel applications for liposuction, lipectomy, liposculpting, and ultrasonic fat harvesting and emulsification devices, especially those devices that provide in situ visualization. The application includes immediately transferring harvested autologous fat from the liposuction, lipectomy, liposculpting, or ultrasonic device to an injector portion on the fat harvesting and emulsifying device or to a separate injector unit that injects it into muscle to provide a higher value, more desirable, use for and positioning of the fat in the form of muscle volume expansion.Type: ApplicationFiled: April 16, 2012Publication date: October 18, 2012Inventor: David L. Matlock
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Patent number: 8283169Abstract: A device and method in which cells of a heterogeneous population are separated through a column partially packed with antibody coated beads. The antibody coated beads may be placed in a gradient fashion such that each layer binds to and selects a subset of cells from the entire sample population. A lipoaspirate fluid, or other fluid containing cells, may be brought through the column by positive pressure on the specimen bag side and negative pressure at the base of the column with a vacuum line and waste trap. The column may then be inverted and irrigated internally with a wash buffer to remove unhomogenized macroscopic tissue material and unbound residual cells. The column may be closed at the ends and shaken and/or washed with an enzymatic buffer. Cells may be removed from the device with an elution buffer.Type: GrantFiled: March 8, 2008Date of Patent: October 9, 2012Inventor: Allan Yang Wu
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Publication number: 20120230950Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.Type: ApplicationFiled: May 21, 2012Publication date: September 13, 2012Applicant: Humacyte, Inc.Inventors: Laura Niklason, Yuling Li, Juliana Blum, Shannon Dahl, Geoffrey Erickson, Frank Zeigler
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Process for isolating biomaterial from tissue and an isolated biomaterial extract prepared therefrom
Patent number: 8263135Abstract: A process for isolating a biomaterial extract from tissue is disclosed. The process comprises the step of contacting the tissue with an extracting solution so as to extract a biomaterial into solution. A solution containing the biomaterial extract is separated before being freeze-dried at a rate sufficient to enable the biomaterial to be isolated. The examples relate to the extraction of collagen from skin or hide using an acetic acid solution as the solvent.Type: GrantFiled: September 9, 2004Date of Patent: September 11, 2012Inventors: Jackie Y. Ying, Shona Pek -
Publication number: 20120225131Abstract: The present invention provides for methods of treating diabetes by providing to a subject brown adipose tissue. The tissue may be transplanted from a culture of the subject's own tissue (autograft) or from a donor. These methods can achieve normoglycemia and suppress hypergluconemia, and alleviate conditions associated with such, even in the absence of or at extremely low levels of adjunct insulin therapy, and without any appreciable increase in insulinogenesis.Type: ApplicationFiled: February 27, 2012Publication date: September 6, 2012Applicant: VANDERBILT UNIVERSITYInventors: DAVID W. PISTON, SUBHADRA C. GUNAWARDANA
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Publication number: 20120225056Abstract: The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.Type: ApplicationFiled: November 10, 2009Publication date: September 6, 2012Applicant: Alexion Pharmaceuticals, Inc.Inventors: Russell P. Rother, Camille Bedrosian, Stephen P. Squinto, Leonard Bell
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Publication number: 20120195969Abstract: Disclosed are methods and compositions for treatment of acne or acneform conditions, particularly but not limited to, acne vulgaris with products generated from culture of stem or progenitor cells. Specifically, compositions of matter are disclosed which are useful for the treatment of acne and acne associated disease states, in particular acne vulgaris, by topical administration of products derived from stem cells or progenitor cells.Type: ApplicationFiled: September 29, 2011Publication date: August 2, 2012Applicant: AIDAN RESEARCH AND CONSULTING, LLCInventors: Neil H. Riordan, Tierney M. Riordan
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Publication number: 20120189707Abstract: The present invention relates to a production method for cryopreserved acellular dermal matrix and to cryopreserved acellular dermal matrix produced thereby, and more specifically it relates to a method in which a cryopreservation agent is made by adding sucrose to basic components consisting of glycerol and a basic solution and in which the resulting solution is used in the cryopreservation of skin tissue from which the cells in the epidermis and dermis have been removed, and relates to cryopreserved acellular dermal matrix produced thereby.Type: ApplicationFiled: September 9, 2010Publication date: July 26, 2012Applicant: INDUSTRY ACADEMIC COOPERATION FOUNDATION HALLYM UNIVERSITYInventors: Wook Chun, Weon Ik Choi, Man Seong Park, Geun Hyung Kim, Jae Deuk Jung
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Publication number: 20120189588Abstract: The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.Type: ApplicationFiled: August 11, 2010Publication date: July 26, 2012Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Zayna Nahas, Jennifer H. Elisseeff, Iwen Wu
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Publication number: 20120189708Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.Type: ApplicationFiled: February 16, 2012Publication date: July 26, 2012Applicant: ALLERGAN, INC.Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
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Publication number: 20120156265Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: ApplicationFiled: February 27, 2012Publication date: June 21, 2012Applicant: DEPUY MITEK, INC.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Publication number: 20120135083Abstract: A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.Type: ApplicationFiled: February 2, 2012Publication date: May 31, 2012Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Masaharu KUROHASHI, Yoji Shibayama
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Patent number: 8187639Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: September 27, 2006Date of Patent: May 29, 2012Assignee: Tissue Tech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8182840Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: September 27, 2006Date of Patent: May 22, 2012Assignee: Tissue Tech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8153162Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: September 27, 2006Date of Patent: April 10, 2012Assignee: Tissuetech, Inc.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 8084052Abstract: The invention herein provides for an improved pesticide that includes at least one attractant, at least one plant growth stimulator and an insecticide. The pesticide eradicates fire ants and promotes the destruction of empty nests by subsequent plant growth.Type: GrantFiled: January 12, 2009Date of Patent: December 27, 2011Inventors: James W. Mason, Marianne L. Mason
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Publication number: 20110293577Abstract: Provided herein is a use of an adipose tissue-derived cell suspension which comprises adipocytes for the preparation of a pharmaceutical composition for use in the treatment of an inflammatory disorder, a cartilage or bone disorder and/or the alleviation of pain associated with an inflammatory disorder in a mammalian subject. Also provided herein is a method of treating an inflammatory disorder, a cartilage or bone disorder or alleviating pain associated with an inflammatory disorder in a mammalian subject, comprising administering to the subject a pharmaceutical composition which comprises: (i) an adipose tissue-derived cell suspension which comprises adipocytes; or (ii) a cell-free extract which is prepared from an adipose tissue-derived cell suspension, wherein the adipose tissue-derived cell suspension comprises adipocytes, together with a pharmaceutically-acceptable carrier or diluent.Type: ApplicationFiled: August 20, 2009Publication date: December 1, 2011Applicant: REGENEUS PTY LTD.Inventor: Graham Vesey
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Publication number: 20110268814Abstract: The present invention provides a method for treatment of acute cerebrovascular diseases, and also provides the use of the extracts from rabbit skin inflamed by vaccinia virus in the manufacture of a medicament for treatment of acute cerebrovascular diseases.Type: ApplicationFiled: October 23, 2009Publication date: November 3, 2011Applicant: VANWORLD PHARMACEUTICAL (RUGAO) CO., LTD.Inventor: Mansang Lau
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Publication number: 20110238186Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.Type: ApplicationFiled: March 24, 2011Publication date: September 29, 2011Inventors: Rick Owens, Wendell Sun, Mike Liu, Yong Mao
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Patent number: 8021882Abstract: A method for producing stem cell conditioned media for treatment of neurological insults is provided herein. By providing for the culture of adipose stem cells, and collecting the supernatants thereof, the supernatants have been shown to effect biological activity in preventing neural death when the supernatants are administered to a patient that has or is about to be subjected to a neural insult.Type: GrantFiled: August 24, 2007Date of Patent: September 20, 2011Inventors: Brian H. Johnstone, Keith Leonard March, Yansheng Du
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Publication number: 20110217387Abstract: A pharmaceutical composition for the treatment of fibromyalgia, which includes pilocarpine or a pharmacologically acceptable salt thereof. The pharmaceutical composition can be used as a novel therapeutic agent for fibromyalgia.Type: ApplicationFiled: May 15, 2009Publication date: September 8, 2011Applicant: AXIS, INC.Inventors: Kusuki Nishioka, Hiroshi Oka, Rieko Nohara
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Publication number: 20110183001Abstract: The invention provides compositions and methods for the preparation of biocompatible biomaterials from adipose tissue. Biocompatible biomaterials are cellular or acellular biomaterials. The invention further provides methods of use of the biocompatible biomaterials.Type: ApplicationFiled: February 11, 2009Publication date: July 28, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Gedge Rosson, Jennifer H. Elisseeff, Zayna Nahas, Zhaoyang Ye, Alexander Hillel
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Publication number: 20110151005Abstract: Cellfree adipose tissue extracts, implants including the same and methods for the preparation thereof. The extracts and implants are capable of inducing adipogenesis and angiogenesis and are, thus, useful in applications including soft tissue repair and engineering and angiogenesis induction, e.g., in wound healing, treatment of burn injuries and ischemic conditions.Type: ApplicationFiled: March 4, 2011Publication date: June 23, 2011Inventors: Timo YLIKOMI, Jertta-Riina Sarkanen
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Publication number: 20110151011Abstract: This invention provides a method for decellularizing adipose tissue, comprising subjecting the adipose tissue to one or more incubations in an enzymatic digestion solution containing one or more enzymes, and one or more solvent extractions, wherein decellularized adipose tissue comprising an extracellular matrix with well-preserved three-dimensional structure is obtained. The invention also provides a decellularized adipose tissue comprising an extracellular matrix with well-preserved three-dimensional architecture, and bioscaffolds, microcarrier beads, and coatings comprising the decellularized adipose tissue.Type: ApplicationFiled: December 17, 2010Publication date: June 23, 2011Inventor: Lauren E. Flynn
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Patent number: 7919121Abstract: A tissue graft composition comprising liver basement membrane and a method of preparation of this tissue graft composition are described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.Type: GrantFiled: January 9, 2003Date of Patent: April 5, 2011Assignee: Purdue Research FoundationInventors: Stephen Francis Badylak, Eric James Rodenberg
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Publication number: 20110033556Abstract: A natural pharmaceutical preparation for treating hypoproteinemia, includes at least one member selected from the group consisting of a drug of increasing human serum albium, a drug of improving and enhance immunity, a drug of treating hepatitis B, a drug of treating Hepatitis C, a drug of treating acquired immune deficiency syndrome (AIDS), a drug of treating Tuberculosis, a drug of treat Fibrosis, a drug of treating hydrothorax, a drug of easing pain, a drug of stopping diarrhea, a drug of arresting coughing, a drug of reducing inflammation, and a drug of increasing urine.Type: ApplicationFiled: June 4, 2010Publication date: February 10, 2011Inventors: Zheming Jin, Xitian Zhang
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Publication number: 20110002996Abstract: The invention provides acellular tissue matrices made from collagen-containing tissues of animals genetically modified so as to be deficient in the galactose 1,3-galactose epitope and methods of making and using such acellular tissue matrices.Type: ApplicationFiled: September 16, 2010Publication date: January 6, 2011Applicant: LifeCell CorporationInventors: David J. McQuillan, Edward S. Griffey, Herbert Daniel Beniker, Hui Xu
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Publication number: 20110003009Abstract: The present invention relates to a process for obtaining a rabbit skin containing biologically active substances. The rabbit skin extract is obtained by the process including vaccinating a rabbit subcutaneously with vaccinia virus, feeding the rabbit, killing the rabbit when the skin is inflamed, skinning the rabbit within 15 minutes of death, preserving the rabbit skin at ?18 degrees Celsius, extracting a portion of the rabbit skin with a phenol solution at 4° C., processing the rabbit skin extract with an acid and an alkali, eluting the rabbit skin extract and fractioning under a nitrogen atmosphere the eluted portion of the rabbit skin extract. The rabbit skin of the present invention can be used for preparing drugs and health foods.Type: ApplicationFiled: September 13, 2010Publication date: January 6, 2011Applicant: VANWORLD PHARMACEUTICAL (RUGAO) COMPANY LIMITEDInventor: Wing Sum Cheung
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Patent number: 7833522Abstract: A method is disclosed to treat a patient having a wound area, such as a burn injury. The method provides a plurality of epidermal/dermal cells, and applies that plurality of epidermal/dermal cells to the wound area.Type: GrantFiled: August 7, 2006Date of Patent: November 16, 2010Inventor: David M. Dixon
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Patent number: 7771754Abstract: Methods and devices to process harvested skin tissue and reintroduction of the ground tissue to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue and a second opening in fluid connection with the first opening. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing through the second opening.Type: GrantFiled: September 14, 2006Date of Patent: August 10, 2010Inventor: Omeed Memar