Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

Abstract: The present disclosure relates to a nail coating system comprising a basecoat, a color layer, and a topcoat. The system of the present disclosure may be applied to natural and/or pre-existing artificial nail coatings. The present disclosure relates generally to compositions for natural and artificial nail coatings, and particularly, but not by way of limitation, to polymerizable compositions and color layers polymerized therefrom. The disclosure further relates to methods of making a polymerized color layer.

Abstract: A Natural oils composition for hardening and strengthening fingernails and toenails in which the natural oils contained therein exhibit ability to self polymerize into a solid film in the presence of oxygen. Oils of this invention are diluted with compatible solvents allowing penetration into the nail. Oils of this invention exhibit an Iodine Value greater than 140 grams of iodine absorbed per 100 grams of oil as measured under the prescribed conditions of a standard method described forthwith. Fingernail strengthening and conditioning compositions with antifungal properties are also disclosed.

Abstract: A powder composition containing at least one fat-soluble vitamin dispersed in a matrix of a natural polysaccharide gum or a mixture of gums having an emulsifying capacity and/or a protein or a mixture of proteins having an emulsifying capacity. The fat-soluble vitamin in the powder compositions is in the form of droplets having an average diameter in the range of about 70 to about 200 nm. Tablets, beverages and beverage concentrates, foods, cosmetics and pharmaceuticals containing the powder composition can be made.

Abstract: A Natural oils composition for hardening and strengthening fingernails and toenails in which the natural oils contained therein exhibit ability to self polymerize into a solid film in the presence of oxygen. Oils of this invention are diluted with compatible solvents allowing penetration into the nail. Oils of this invention exhibit an Iodine Value greater than 140 grams of iodine absorbed per 100 grams of oil as measured under the prescribed conditions of a standard method described forthwith. Fingernail strengthening and conditioning compositions with antifungal properties are also disclosed.

Abstract: The present invention relates generally to the field of primers and adhesion promoters. More specifically, the primer of the present invention is comprised of one or more multi-carbonylated methacrylates. In a preferred embodiment, a non-ketone polar solvent is also employed. The resulting composition eliminates primer related discoloration of artificial nail enhancements, eliminates the potential for corrosion of skin and nails, and eliminates risk of chemical burn injury, while providing stronger adhesion than currently available primers.

Abstract: Disclosed herein are methods of making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming a film on the keratinous substrate by applying to said keratinous substrate (a) a first cosmetic composition comprising at least one polyvinyl alcohol-styrylpyridinium polymer and (b) a second cosmetic composition comprising at least one complexing agent, and (2) exposing the film to radiation chosen from UV and visible light radiation.

Abstract: Disclosed herein are cosmetic compositions comprising (1) at least one polyvinyl alcohol-styrylpyridinium polymer and (2) at least one latex film-forming polymer. Also disclosed herein are methods for making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming a film on the keratinous substrate by applying to said keratinous substrate a cosmetic composition comprising (a) at least one polyvinyl alcohol-styrylpyridinium polymer and (2) at least one latex film-forming polymer and (2) exposing the film to radiation chosen from UV and visible light radiation.

Abstract: The present invention is directed to compositions and methods for enhancing the health of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to enhance nail health. The composition is also effective in strengthening and growing nails.

Abstract: The present invention is directed to cyclosporine compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails.

Abstract: The invention provides long lasting and quick drying nail polish compositions for application to natural or artificial nails. The nail polish composition comprises a lacquer component and an optional pigment component. The lacquer component can harden in ambient atmosphere without the use of ultraviolet radiation. The lacquer component includes acrylic polymers dissolved in organic solvents.

Abstract: This invention relates to nail coating compositions, to packages including the nail coating compositions, to methods of applying the nail coating composition to a nail and to a use of an additive compound to improve the properties of the nail coating composition of the present invention. In particular, the invention relates to nail coating compositions having improved chip resistance, good adhesion to the nail, a high gloss finish and a short dry-to-touch time.

Abstract: A saccharide siloxane copolymer is useful as an emulsifier. Emulsions prepared with the saccharide siloxane copolymer are useful in personal care products.

Abstract: The present invention relates to five-layered pigments based on multicoated platelet-shaped substrates which comprise a layer sequence comprising (A) a layer of SnO2 having a layer thickness of 0.1-50 nm, (B) a high-refractive-index coating consisting of TiO2 in the rutile modification having a layer thickness of 10-800 nm, (C) a colorless coating having a refractive index n?1.8 having a layer thickness of 20-800 nm, (D) a high-refractive-index coating consisting of SnO2 having a layer thickness of 0.1-50 nm, (E) a layer of TiO2 in the rutile modification having a layer thickness of 10-800 nm, and optionally (F) an outer protective layer, and to the use thereof in paints, coatings, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, as dopants for the laser marking of papers and plastics, in cosmetic formulations and for the preparation of pigment preparations and dry preparations.

Abstract: A novel saccharide siloxane copolymer is useful in personal care compositions. The saccharide siloxane copolymer may be used as a universal emulsifier to prepare low odor emulsions for personal care applications.

Abstract: An emulsion contains a saccharide siloxane copolymer as an emulsifier. The emulsion is useful in formulating personal care products.

Abstract: Provided is a manicure composition of a French nail type which has less disturbance of the lines brought about by a base color and a topcoat and is quickly dried, which does not cause dew condensation on the coating film under a moist environment for coating and has less leveling and less irregular color and which is excellent in a drying property, an adhesive property, flexibility, a masking property, a finished property, a discharge performance and a restirring property. The above manicure composition comprises at least ethanol and propylene glycol monomethyl ether as a solvent, titanium oxide A having an average primary particle diameter of 200 to 400 nm, titanium oxide B having an average primary particle diameter of 10 to 80 nm, an acrylic resin, polyether-modified polydimethylsiloxane and a plasticizer.

Abstract: The present invention relates to a cosmetic composition comprising: a) a supramolecular oil (compound A) which can be obtained by reaction between an oil bearing at least one nucleophilic reactive function and a joining group capable of establishing hydrogen bonds, said joining group bearing a reactive function capable of reacting with the reactive function borne by the oil, and said joining group also comprising at least one unit of formula (Ia) or (Ib): b) a polyalkene-based supramolecular polymer (compound B) which can be obtained by reaction of a functionalized polyalkene polymer with a functionalized joining group, said joining group being capable of forming at least three H (hydrogen) bonds. The invention also relates to a cosmetic treatment process using said composition.

Abstract: The present invention is directed to compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails.

Abstract: The present invention relates to a cosmetic process for treating a keratin material, characterized in that it comprises at least one step of applying to the said keratin material a coating formed from a liquid composition comprising, in a cosmetically acceptable medium, at least one copolymer containing polyamide blocks and polyether blocks resulting from the co-polycondensation of polyamide blocks containing reactive ends with polyether blocks containing reactive ends; the said copolymer being in solution or in dispersion, and at least one organic solvent. The present invention also relates to a cosmetic assembly comprising a) at least one liquid composition comprising, in a cosmetically acceptable medium, at least one copolymer containing polyamide blocks and polyether blocks in solution or in dispersion, and at least one organic solvent; b) a device for applying the said composition to the keratin materials.

Abstract: The present invention is directed to cationic nanoparticles, methods to make them, and the use of compositions containing said nanoparticles in personal care compositions or formulations. The nanoparticles are useful in personal care applications and impart antimicrobial properties to home and personal care products containing them. These cationic nanoparticles also contribute useful conditioning properties to hair-care and skin-care products.

Abstract: An object of the present invention is to provide an artificial nail composition which can improve adhesion between a natural nail and an artificial nail, and also can suppress exfoliation or detachment. The artificial nail composition comprises: (a) a compound having at least one radical polymerizable unsaturated double bond in the molecule, (b) an acidic phosphorus compound having at least one radical polymerizable unsaturated double bond in the molecule, and (c) a radical polymerization initiator.

Abstract: Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them. Various locations and methods for placement of the compositions into the tissues of the nail unit, as well as tissues surrounding the nail unit are also described.

Abstract: Aqueous pharmaceutical system for the administration of drugs to the nails. The invention relates to a topical preparation for treating diseases of the toenails and/or hands nails, based on a thermosensitive aqueous gel that at room temperature behaves as a dissolution and after application of nails, forming a hydrated layer, film or hydrogel from which release the active ingredients. The composition of the gel contains mostly water, a gel-forming polymer sensitive to changes in temperature, solubilizing agents and enhancers of absorption and/or penetration of the drug in nails.

Abstract: A cosmetic composition for bleaching discolored nails containing at least one hydrogen peroxide generator in an amount sufficient to perform bleaching of discolored nails, at least one film forming polymer and at least one cosmetically acceptable volatile solvent. Also disclosed is a method of bleaching discolored nails involving applying onto said nails the cosmetic composition of the present invention.

Abstract: Described herein are copolymers comprising at least one first water-soluble monomeric unit, at least one second water-soluble monomeric unit, and at least one monomeric unit containing a basic residue.

Abstract: The present invention is directed to compositions and methods for enhancing the health of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to enhance nail health. The composition is also effective in strengthening and growing nails.

Abstract: Disclosed are cosmetic compositions comprising at least one latex-film former chosen from at least one random styrene acrylate copolymer and derivatives thereof, and at least one coalescent and/or plasticizer.

Abstract: Disclosed are cosmetic compositions comprising at least one latex-film former chosen from at least one acrylate copolymer and derivatives thereof, and at least one coalescent and/or plasticizer.

Abstract: The use of specific compounds of the Formula 1 (and also corresponding mixtures) in particular as cosmetic agents for the inhibition of the substance P-induced release of histamine from mast cells is described.

Abstract: A novel artificial nail composition (gel nail composition) is provided. The artificial nail composition is curable with ultraviolet rays to form an artificial nail, and includes an ultraviolet-curable resin and pearl powder dispersed in the ultraviolet-curable resin.

Abstract: A water-soluble capsule for use in a pedicure bath that comprises the following substances: Dead Sea salts, olive oil, sodium bicarbonate, citric salt, starch, and fragrance. A method of manufacturing the capsule that includes the following stages: The aforementioned substances are placed in a mixer and a little water is added until a pourable mixture is obtained; the mixture is poured into a mold; pressure is applied to the capsule while in the mold; the mixture is dried in the mold until a solid capsule is obtained.

Abstract: A description is given of the use of phenolic antioxidants of formulae (1) and/or (2) and/or (3) for stabilizing body-care and household products.

Abstract: Onychomycosis is a fungal infection of the nail bed and is difficult to treat topically because penetration of the nail plate is difficult, and systemic antifungal treatments are prone to side effects and drug interactions. The present invention treats onychomycosis by applying an antifungal composition to the nail bed directly using a solid, semi-solid, or flowable carrier. The carrier can be in the form of a semi-solid into which the user digs and scrapes the nail, a solid carrier can be inserted directly under the nail in contact with the nail bed, or a flowable composition can be injected in contact with the nail bed.

Abstract: The present disclosure relates generally to compositions for natural and artificial nail coatings, and particularly, but not by way of limitation, to polymerizable compositions and adhesion-promoting basecoats polymerized therefrom. The disclosure further relates to methods of making a polymerized basecoat that are more easily removed than artificial nail enhancements and more durable and long lasting than nail polish coatings.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: The present invention relates to a flexible article for application to the nails and/or false nails so as to make them up and/or care for them, the article comprising at least one adhesive layer, and being characterized in that said adhesive layer comprises at least two block copolymers, a tackifier resin, and a plasticizer.

Abstract: The invention relates to novel compounds of dibenzylidene sorbitol ester type corresponding to the following formulae (I) and (II): in which: R, R? and R? represent a hydrogen atom or a —C(O)Y radical in which Y represents a C2-C25 hydrocarbon radical or an optionally substituted aryl radical; the R1, R2, R3, R4, R5, R?1, R?2, R?3, R?4 and R?5 radicals represent a hydrogen atom; a C1-C18 alkyl radical; a C1-C18 alkoxy radical; a phenoxy radical; an optionally substituted phenyl radical; or a benzyl radical; the divalent radical A represents, in the formula (II), a C1-C52 hydrocarbon radical; an optionally substituted arylene radical; or a silicone radical. The invention also relates to their process of preparation, to their use in structuring lipophilic media, in particular oils, to the cosmetic or pharmaceutical compositions comprising them and to a cosmetic treatment method employing them.

Abstract: A composition, method, and use of a UV curable, thixotropic, radiation curable, low viscosity gel is described. The composition is comprised of thixotropic additive(s) and in some cases dispersants for additional dispersion stability. The thixotropic pigmented gel has prolonged shelf life and long time storage at ambient conditions. It also contains negligible amounts of unreactive solvent. The thixotropic additive also changes the rheological properties of the gel, which allows the nail gel to be easily applied to nails at a lower viscosity due to shear thinning.

Abstract: A method of preparing colored UV-curable artificial nail gel compositions comprising dispersing a pigment in an organic liquid to form a pigment concentrate and mixing the pigment concentrate with a polyfunctional acrylic monomer and/or a polyfunctional acrylic oligomer, and the resultant highly colored artificial nail gel are disclosed.

Abstract: A linear, block copolymer, which is useful in cosmetics and improves the styling power and hold of hair laquer, adhesion of nail varnish and hold/adhesion of makeup, includes at least two blocks having different glass transition temperatures, Tg; where at least one of said blocks has a glass transition temperature of 20° C. to ?100° C., and wherein the at least one block having a Tg of 20° C. to ?100° C. is a copolymer B having a first monomer wherein the Tg of the corresponding homopolymer is in the range from more than 20° C. to 200° C., and a second monomer wherein the Tg of the corresponding homopolymer is in the range from 20° C. to ?100° C.

Abstract: The present disclosure relates to a nail coating system comprising a basecoat, a color layer, and a topcoat. The system of the present disclosure may be applied to natural and/or pre-existing artificial nail coatings. The present disclosure relates generally to compositions for natural and artificial nail coatings, and particularly, but not by way of limitation, to polymerizable compositions and color layers polymerized therefrom. The disclosure further relates to methods of making a polymerized color layer.

Abstract: A method of preparing colored ultraviolet (UV)-curable compositions useful for adornment of natural and artificial nails and artificial nail extensions comprising dispersing a pigment in an organic liquid to form a pigment concentrate, the organic liquid comprised of one or more organic chemicals selected from solvents, ethylenically unsaturated monomers, and ethylenically unsaturated oligomers; and mixing the dispersed pigment concentrate with a radiation-curable nail gel composition comprising one or more ethylenically unsaturated monomers, one or more ethylenically unsaturated oligomers, or mixtures thereof, and, optionally, one or more photo accelerators, fillers, inhibitors, plasticizers, non-reactive polymers, adhesion promotors, and/or photoinitiator(s) to form a resultant mixture, wherein if photoinitiator(s) is/are not present in the nail gel composition the photoinitiator(s) is/are added to the resultant mixture of the pigment concentrate and radiation-curable nail gel composition.

Abstract: The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug for treating various skin infections, such as fungal, bacterial, and/or viral skin infections. The formulation can include anti-infective drug, solvent vehicle, and solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained periods of time. The non-volatile solvent system can also act to plasticize the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

Abstract: The invention relates to a cosmetic or dermatological composition comprising a hyaluronic acid derivative which comprises ureidopyrimidone units, to the said derivatives and to a cosmetic treatment method using them.

Abstract: The invention relates to a cosmetic composition, especially a hair composition, and to a method for the cosmetic treatment of keratin materials, especially of the hair, employing compounds of formula: in which Z represents (i) a hydrogen atom, (ii) a linear or branched C1 to C32 (saturated) alkyl radical; (iii) a linear or branched C2 to C32 (unsaturated) alkene radical, comprising one or two C?C double bonds; (iv) an aryl-substituted alkyl radical; said radicals being optionally substituted and/or interrupted.

Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include greater than 30% by weight of the active agent, and may be formulated as solutions, solids, semisolids, microparticles, or crystals. Methods related to the implantation and use of the biodegradable drug delivery systems for treating nail unit conditions are also described.

Abstract: A pharmaceutical composition for external use, including: i) luliconazole represented by the following structural formula (1) and/or a salt thereof; and ii) one or two or more selected from N-methyl-2-pyrrolidone, propylene carbonate, and crotamiton.

Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

Abstract: A dermatological composition for application to the skin or nails comprises a salt of a cation and an anion. The cation is derived from a monomeric or polymeric molecule that will generate an amidine moiety, a guanidine moiety or a biguanide moiety. The anion is derived from a monomeric or polymeric molecule that will generate a carboxylic acid moiety. The composition may be prepared by a metathesis or acid-base reaction.