Abstract: New superparamagnetic particles useful in medicine for destroying tumors, increasing immunity and diagnosing conditions are disclosed. For that purpose, very small superparamagnetic single-domain particles are aggregated and protected against further aggregation by chemical bonding of reactive stabilizer substances on the surface of the superparamagnetic particles. These new particles thus consist of stable, decomposable aggregates with a particle size in a range between 10 and 1000 nanometers and a defined behavior in a magnetic field.

Abstract: Short term control of ammonia volatilization from animal manures is provided by surface treatment with aluminum sulfate. The aluminum sulfate may be applied to manure or manure receiving surfaces in an animal rearing facility in solid or liquid form. The control of atmospheric ammonia levels in animal rearing facilities to preferably less than about 25 ppm ammonia can be achieved by surface treatment employing amounts of alum as low as 0.5% by weight alum based on manure present.

Abstract: The invention relates to methods and compositions for delivering iron to an iron-deficient patient, more particularly, to methods whereby an iron complex comprising divalent or trivalent ionic iron complexed with one or more low molecular weight anions is administered to a patient by transfer from dialysate. A complex selected according to the invention is non-polymeric; soluble in an aqueous medium; chemically stable, thereby preventing the dissociation of iron ions from the anions under conditions according to the invention; and can be well absorbed into blood and the living body. Also provided are dialysate compositions including therein an iron complex selected according to the invention, and dialysate concentrates which may be diluted to yield an inventive dialysate composition.

Abstract: The present invention proposes a water-proof deodorizing, bedsore-preventing sheet that can not only eliminate the bad smell from the wastes of bedridden sick persons but also prevent the bedsore or its worsening and a method for manufacturing the same. The present invention gives such a manufacturing method that the sheet-shaped deodorizing material D obtained by allowing a sheet-shaped member made of a cellulose-based substance to contain ferrous sulfate which is subsequently oxidized into basic ferric sulfate is coated with the permeable film 1, whose fringes are partially sealed subsequently.

Abstract: A magnetic-polymer particle, useful in immunoassay techniques and various other biological/medical applications is produced by coprecipitation of transition metals in the presence of a polymer having available coordination sites. These particles are capable of forming stable aqueous suspensions and may be easily resuspended after agglomeration.

Abstract: The invention provides a method of contrast enhanced MR angiography of the human or non-human animal body, said method comprising administering into the vasculature thereof a contrast effective amount of a contrast agent composition comprising magnetic particles having a r.sub.2 /r.sub.1 ratio of no more than 5, and, at a time when sufficient of said magnetic particles remain in the vasculature to provide positive contrast enhancement thereof in a T.sub.1 -weighted image while sufficient magnetic particles have been taken up into an organ of the reticuloendothelial system to provide negative contrast enhancement thereof in said T.sub.1 -weighted image, generating a T.sub.1 -weighted image magnetic resonance image of at least said organ.

Abstract: Antiviral and antifungal compositions comprising a mixture of a ferrous salt and a plant extract of pomegranate rind, Viburnum plicatum leaves or flowers, tea leaves, or maple leaves in an aqueous solution are disclosed. The compositions are mainly used to prevent the growth of, or kill, viruses or fungi on surfaces. The compositions do not substantially affect bacterial viability as measured by colony forming ability.

Abstract: Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.

Abstract: A method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves, said matrix being a biocompatible, biodegradable, non-immunogenic, non-polyamino acid polymer; and generating an ultrasonic image of said subject.

Abstract: The invention relates to a preparation for improving the blood supply. The problem with prior art preparations or processes resides in the fact that soft magnetic components had to be introduced into the body in capsule form or a magnetic field had to be applied after the application of demagnetized particles to the skin. The purpose of the invention is to provide a novel preparation for improving the blood supply in which special hard magnetic particles are used. According to the invention, the preparation for improving the blood supply consists of a pharmaceutically or cosmetically acceptable medium and possibly further additives containing finely distributed hard magnetic single-grade particles with a high coercitive field intensity and grain sizes in the range of 600 to 1200 nm. Dispersions of this preparation exhibit no aggregation of the hard magnetic particles. The preferred use is in the cosmetic and dermatological field.

Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.

Abstract: The invention provides for the use of a physiologically tolerable, particulate, free or matrix-borne, ferromagnetic, ferrimagnetic or paramagnetic material for the manufacture of a diagnostic agent for magnetometric imaging of a human or non-human animal body.

Abstract: A substance produced from a combination of acid based ingredients and a mole attracting herb. Placement of the substance into a mole tunnel attracts the mole and upon contact with the substance becomes repelled by the acid taste.

Abstract: A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type MR contrast agents described herein comprised of biodegradable superparamagnetic metal oxides associated with a variety of macromolecular species, including but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal species, polysaccharides, arabinogalactan, or conjugates of these molecules with other polymeric substances such as a poly(organosilane) and dextran. One of the advantages of these MR contrast agents is that they may be selectively directed to those cells which bear receptors for a particular macromolecule or ligand and are capable of undergoing receptor mediated endocytosis.

Abstract: A method of contrast enhanced ultrasonic diagnostic imaging comprising: administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves, said matrix being a biocompatible, biodegradable, non-immunogenic non-polyamino acid synthetic polymer; and generating an ultrasonic image of said subject.

Abstract: An oral composition for the prevention of anaemia, comprising highly bioavailable iron and an amino acid-containing ingredient which composition may be ingested voluntarily by a suckling animal in sufficient amounts to maintain a physiologically normal blood composition of the animal, a spray-drying method of manufacturing such a composition comprising an inner core coated with a continuous layer comprising the amino acid-containing ingredient.

Abstract: The present invention relates to dietary supplements for supplementing the dietary needs of women and preventing or reducing life stage associated health risks during each of their principal adult life stages (pre-perimenopause, perimenopause and menopause, or post-menopause).

Abstract: A method of delivering NO gas to a desired situs on or in the body of a sentient animal, e.g. humans, comprising combining and causing to react a soluble reducing salt, preferably ferrous sulfate, and a nitrite, preferably sodium nitrite, as reactants in the presence of moisture in situ at or adjacent such situs. Means for such delivery include compositions such as tablets, capsules, ointments, creams, lotions, and sprays containing mixtures of particles or granules of the two reactants, and transdermal patches and osmotic pumps for combining solutions of reactant or reactants in situ.

Abstract: This invention provides methods of treatment and/or diagnosis and/or siting of viruses including the AIDS virus and others as well as the cells which they infect. The method comprises introducing near, into or onto the virus or the cell which the virus infects, or both, minute particles. These particles possess ferromagnetic, paramagnetic or diamagnetic properties. After being localized near, in or on the virus or the viral-infected cell, the particles are inductively heated by application of an alternating electromagnetic field. The inductive heating is continued for a period of time sufficient to bring about a temperature rise to a minimum necessary to kill the virus or cell or to desirably alter the behavior of the virus or infected cell. Prior to, during or after treatment, these particles can be used diagnostically to locate and/or map the virus in the living tissue.

Abstract: This invention provides methods of treatment and/or diagnosis and/or siting of viruses including the AIDS virus and others as well as the cells which they infect. The method comprises introducing near, into or onto the virus or the cell which the virus infects, or both, minute particles. These particles possess ferromagnetic, paramagnetic or diamagnetic properties. After being localized near, in or on the virus or the viral-infected cell, the particles are inductively heated by application of an alternating electromagnetic field. The inductive heating is continued for a period of time sufficient to bring about a temperature rise to a minimum necessary to kill the virus or cell or to desirably alter the behavior of the virus or infected cell. Prior to, during or after treatment, these particles can be used diagnostically to locate and/or map the virus in the living tissue.

Abstract: A microgranular preparation having a core of biologically active material that is encapsulated by a water soluble film that is covered by an enteric coating of either an alkali soluble, acid insoluble polymer or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acids or other material capable of being solubilized by intestinal juices. Useful for protecting pH sensitive and other biologically active materials from inactivation or contact with the stomach or rumen, and releasing the same in active form in the intestinal tract, particularly the duodenum.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: Cosmetic product having a stabilized redox potential, comprising, in contact with one another, a cosmetic composition comprising, in an aqueous medium, a water-soluble metal salt, and the metal corresponding to this water-soluble metal salt. The stability of the redox potential of the cosmetic product of the present invention enables the properties of the cosmetic composition, in particular the physiological properties, to be exceptionally well preserved.

Abstract: Disclosed are compositions useful in nuclear magnetic resonance imaging comprising a matrix which exhibits a volume phase change in response to an electric field, the matrix containing a magnetic and preferably superparamagnetic component distributed therethrough.

Abstract: The invention provides the use of a physiologically tolerable, particulate, free or matrix-borne, ferrimagnetic or ferromagnetic material for the manufacture of a diagnostic agent for administration into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity (e.g. into the synovial fluid or the vasculature) or the musculature for magnetometric imaging of the human or non-human animal body.

Abstract: The present invention relates to a method for manufacturing tea by treating the leaves of cyclobalanopsis stenophylla. The leaves of cyclobalanopsis stenophylla are collected in May or June and, directly thereafter, are treated with steam for 50.+-.10 minutes. When their green color changes into a yellowish brown and a savory smell is given out, they are taken out and desiccated in the shade and, then, based on volume, 5% to 10% of glutinous rice or polished glutinous millet is mixed in 90% to 95% of water and put in the bottom of a steamer. A bored plate is placed on the steamer, and the desiccated leaves are put down on the plate and treated for 20.+-.5 minutes with steam generated by applying heat to the steamer and the leaves treated with steam are desiccated again and made into tea.

Abstract: Vitiligo and other tyrosinase-positive depigmentation disorders are treated by topical application of a pseudocatalase and subsequent exposure to a sub-minimal erythema dose of UVB light. After a course of treatment, pigmentation of the affected areas can be maintained by treatment with the pseudocatalases without UVB light treatment. The preferred pseudocatalases are transition metal co-ordination complexes, especially manganese (II) bicarbonate.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: The pharmaceutical composition according to the invention consists essentially of:i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium, manganese, iron, cobalt, nickel, copper, zinc and molybdenum, which compounds do not precipitate with each other or with the other components of the composition and exhibit a neutral or acidic pH in an aqueous medium;ii) glycine;iii) glycerol;iv) L-(+)-ascorbic acid;v) succinic acid;vi) a neutral or acidic and water-soluble, pharmaceutically acceptable salt of ethylenediamine tetraacetic acid;vii) potassium sodium tartrate; andviii) L-(+)-tartaric acid. The composition can be used for the treatment of mucoviscidosis and chronic pain syndromes deriving from locomotor diseases or accompanying diseases of tumorous origin.

Abstract: There is provided a contrast medium composition comprising magnetically responsive particles and a physiologically tolerable, incompletely hydrated viscosity enhancing agent.

Abstract: A microgranular preparation having a core of biologically active material that is encapsulated by a water soluble film that is covered by an enteric coating of either an alkali soluble, acid insoluble polymer or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acids or other material capable of being solubilized by intestinal juices. Useful for protecting pH sensitive and other biologically active materials from inactivation or contact with the stomach or rumen, and releasing the same in active form in the intestinal tract, particularly the duodenum.

Abstract: A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type MR contrast agents described herein comprised of biodegradable superparamagnetic metal oxides associated with a variety macromolecular species, including but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal species, polysaccharides, arabinogalactan, or conjugates these molecules with other polymeric substances such as a poly(organosilane) and dextran. One of the advantages or these MR contrast agents is that they may be selectively directed to those cells which bear receptors for a particular macromolecule or ligand and are capable of undergoing receptor mediated endocytosis.

Abstract: There is provided a magnetic resonance contrast medium comprising magnetically responsive particles and a physiologically tolerable osmoactive agent.

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (<5 .mu.m) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

Abstract: Disclosed is a contrast medium for ultrasonic diagnosis, which comprises an aqueous medium and gas-encapsulated particles each having a ferrite magnetic layer on the surface thereof contained in the aqueous medium.

Abstract: A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type MR contrast agents described herein comprised of biodegradable superparamagnetic metal oxides associated with a variety of macromolecular species, including but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal species, polysaccharides, arabinogalactan, or conjugates of these molecules with other polymeric substances such as a poly(organosilane) and dextran. One of the advantages of these MR contrast agents is that they may be selectively directed to those cells which bear receptors for a particular macromolecule or ligand and are capable of undergoing receptor mediated endocytosis.

Abstract: A composition containing magnetic metal oxide ultrafine particles, which comprises an aqueous sol of a complex of the magnetic metal oxide ultrafine particles with a polysaccharide, a polysaccharide derivative and/or a protein; and an organic monocarboxylic acid. The composition is free of side effects such as platelet aggregation, is safe for use with living bodies, and, in the case of intravascular administration, has no harmful effects on living bodies, and is useful in fields such as medicine and diagnostic drugs.

Abstract: The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions.

Abstract: A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type MR contrast agents described herein comprised of biodegradable superparamagnetic metal oxides associated with a variety of macromolecular species, including but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal species, polysaccharides, arabinogalactan, or conjugates of these molecules with other polymeric substances such as a poly(organosilane) and dextran. One of the advantages of these MR contrast agents is that they may be selectively directed to those cells which bear receptors for a particular macromolecule or ligand and are capable of undergoing receptor mediated endocytosis.

Abstract: Pharmaceutically acceptable compositions of one or more n-6 or n-3 essential fatty acids, particularly gamma-linolenic acid, dihomo-gamma-linolenic acid, or eicosapentaenoic acid, and assimilable iron compounds, in dosage unit form optionally with a diluent or carrier, said acids being present as such or as derivatives convertible in the body thereto and the amounts of said acids or derivatives being 1 mg to 100 g (calculated as gamma-linolenic acid) and of said iron compounds 0.1 mg to 10 g (calculated as iron) or submultiples of said amounts convenient for daily administration thereof.

Abstract: Compositions comprising L-glutamine in combination with vitamins, minerals, choline, and flavonoids are disclosed. Such compositions can be administered to effect weight reduction, or to aid in weight control.

Abstract: There is described an iron containing preparation for NMR imaging comprising, as necessary ingredients, the prescribed amounts of an iron containing compound, sodium carbonate or sodium hydrogencarbonate and a neutralizing agent. This preparation is safe, easy to drink, and when taking, provides clear and accurate contrast imaging of inner organs. Further, addition of potassium carbonate to this preparation gives excellent preservation stability.

Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the method includes preparing the colloid in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement may include sterilizing the colloid by filtration. In an additional embodiment, the colloid may be sterilized by filtration and preserved by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion. Other embodiments include related compositions and methods.

Abstract: Formulations or products are caused to be active antimicrobials by the addition thereto of at least one effective amount of at least one crystalline mixed metal hydroxide (MMOH) conforming substantially to the formulaLi.sub.m D.sub.d T(OH) (m+2d+3+na) (A.sup.n).sub.a.xH.sub.2 Owhere m is zero to one, D is a divalent metal, d is from zero to 4, T is a trivalent metal, A represents at least one anion or negative-valence radical, (m+2d+3+na) is equal or to greater than 3, (m+d) is greater than zero, and xH.sub.2 O represents excess waters of hydration. The MMOH forms an adduct with, an coats, the microbes, thereby deactivating the microbes.

Abstract: An orally administered pharmaceutical agent that is particularly suited for iron and magnesium substitutive therapy is disclosed. This drug consists of a combination of one or more pharmaceutically and physiologically compatible iron compounds, one or more pharmaceutically and physiologically compatible magnesium compounds, and, if the magnesium compounds do not contain any chlorine atoms dissociable in aqueous media and saturating the available magnesium valences, the drug further consists of one or more pharmaceutically and physiologically compatible compounds providing chlorine ions in aqueous media. The iron compounds, magnesium compounds and chlorine ion supplying compounds may be mixed with the conventional pharmaceutical solvents and/or thinners and/or auxiliary matter. Unexpectedly, this drug makes it possible to simultaneously administer magnesium or calcium compounds with iron compounds, without thereby causing reduced iron resorption.

Abstract: Pharmaceutically acceptable compositions of one or more n-6 or n-3 essential fatty acids, particularly gamma-linolenic acid, dihomo-gamma-linolenic acid, or eicosapentaenoic acid, and assimilable iron compounds, in dosage unit form optionally with a diluent or carrier, said acids being present as such or as derivatives convertible in the body thereto and the amounts of said acids or derivatives being 1 mg to 100 g (calculated as gamma-linolenic acid) and of said iron compounds 0.1 mg to 10 g (calculated as iron) or submultiples of said amounts convenient for daily administration thereof.

Abstract: There is provided a method of generating enhanced images of the human or non-human animal body, for example for use in medical diagnosis, which involves administering to the body a positive MRI contrast agent which is body tissue- or body duct-specific following the particular mode of administration and a negative MRI contrast agent which preferably also is body tissue- or body duct-specific. Thereafter a magnetic resonance image is generated of a part of the body containing the negative and positive contrast agents or their paramagnetic, ferromagnetic or superparamagnetic biodegradation products. Contrast media suitable for use in this new image generating method are also provided.

Abstract: An orally acceptable nutrient and mineral supplement for reducing hair loss wherein the composition contains divalent iron and pantothenic acid in a weight to weight ratio of approximately 1-3 and racemic d, 1-methionine. A particularly preferred composition contains 11.25 mg. of divalent iron as ferrous fumarate and 35 mg. of pantothenic acid as calcium pantothenate and 200 mg. of d,1-methionine.

Abstract: Nutritional mineral supplements comprise iron compounds and calcium compounds in combination with citrates of tartrates, ascorbates, and, optionally, fructose. The tendency of calcium to inhibit the bio-availability is reduced in such compositions, so that conjoint bioavailability of these two important minerals is enhanced.

Abstract: A pharmaceutical preparation for oral or transdermal treatment of wounds, damaged tissue and inflammation which is a solution containing water and metallic trace elements or salts thereof in a physiological quantity.