Abstract: The present invention relates to the use of combinations of 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and an oxidizing agent, for eradicating, eliminating or reducing aquatic organisms in ballast water or bilge water whereby 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and the oxidizing agent are in respective proportions to provide a synergistic effect against fouling organisms. Suitable oxidizing agents are e.g.

Abstract: An apparatus includes a reservoir for holding a chemical solution, a pump and a discharge nozzle. The pump has an inlet and an outlet connected to the reservoir by inlet and discharge lines. The nozzle is disposed in a lower portion of the reservoir and discharges the solution toward the bottom of the reservoir; the nozzle has an inlet port connected to the pump discharge line through the sidewall of the reservoir. The pump inlet line is connected to a sidewall of the reservoir at a location below a normal surface level of the solution, and the pump discharge line is connected to the sidewall of the reservoir above that location. The reservoir, pump, pump inlet line, pump discharge line, nozzle inlet line and nozzle form a closed loop recirculation system effective to suspend insoluble material in the chemical solution.

Abstract: Fungal infections and other disease conditions of the integument can be effectively treated with compositions containing ozonizable oils and antimicrobials, when used in conjunction with solutions containing sodium chlorite. The compositions are particularly useful for treatment of resistant fungal infections.

Abstract: An improved method and apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution with a broad range of anti-infective and therapeutic applications. The resulting electrolyzed saline solution exhibits a marked lack of toxicity upon intravenous, aspired, oral or topical application in mammals for therapeutic applications providing a broad platform, including topical disinfection, antimicrobial application, wound treatment, oxidative stress reduction and enhancement of immune function to better detect malfunctioning cells.

Abstract: The present invention provides a method of using a solid-layered composition having at least two parts. The first past comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a surfactant b) a builder, c) an acid, and d) wherein the second part does not contain any oxidant.

Abstract: Provided is a method for treating or preventing peritonitis by administering a therapeutically effective amount of an oxidative reduction potential (ORP) water solution that is stable for at least about twenty-four hours. The ORP water solution administered in accordance with the invention can be combined with one or more suitable carriers and can be administered in conjunction with one or more additional therapeutic agents. Further provided is a method for preventing peritoneal hemorrhage, adhesions and abscesses.

Abstract: A composition for anti-microbial effect in a water system such as a pulp and paper processing line with an aqueous slurry. The composition comprises a free chlorine-generating biocide comprising a chlorine source, urea, and an alkali in a concentration sufficient to provide a pH greater than 10, and typically at least pH 11.

Abstract: Provided is an efficient method of inducing differentiation of a pulp cell into an odontoblast. Also provided is an agent for inducing differentiation capable of inducing differentiation into an odontoblast efficiently. The method of inducing differentiation of a pulp cell into an odontoblast includes using a substance capable of activating a Wnt signaling pathway. Further, the agent for inducing differentiation includes a substance capable of activating a Wnt signaling pathway. Specifically, the substance capable of activating a Wnt signaling pathway is any one selected from sodium perchlorate, sodium perchlorate, lithium chloride, Norrin, and R-Spondin2.

Abstract: Described are compositions containing a mixture of (a) particulate calcium hypochlorite and (b) an amount of aluminum hydroxide that is sufficient to increase the UN-burn time of the composition by a factor of at least 2.5 compared to that of the calcium hypochlorite, the composition having an available chlorine content of at least 35 weight percent. Further described are solid compositions of (a) granular calcium hypochlorite having a UN Packing Group oxidizer classification of II, and (b) an amount of aluminum hydroxide such that the composition is classified as a Packing Group III Division 5.1 oxidizer or as a non-Division 5.1 oxidizer, the composition having an available chlorine content of at least 40 weight percent. Further described are formed articles prepared from the above-described compositions.

Abstract: A formulation and method for removing viruses from fresh produce, including at least one surfactant, and a solvent. Preferably, the formulation also includes at least one sanitizer.

Abstract: A composition for producing a biocide solution upon contact with water, the composition comprises at least a hydrogen peroxide donor and polyoxychlorine donor. The biocide solution forms reactive oxygen species when contacted by microorganisms, proteinaceous substances, and reducible organic based contaminants.

Abstract: The present invention provides methods of treating, reducing, and/or preventing the incidence of an influenza related viral infection in a patient comprising administering a therapeutically effective amount of an oxidative reductive potential (ORP) water solution. The present invention also provides methods of reducing or preventing the incidence of an influenza related viral infection in a patient associated with a medical device comprising contacting the medical device with an effective amount of an ORP water solution.

Abstract: Described herein are chlorite formulations having a pH between about 7 and about 8.5, wherein the chlorite formulations are substantially free of deleterious non-chlorite components. Described herein are chlorite formulations, including pharmaceutical formulations, which are formulated for systemic, parenteral, or intravenous administration. Described herein are methods of preparing and methods of using the chlorite formulations described herein.

Abstract: Corrosion inhibitor compositions and methods of use are disclosed. Sugar acids and calcium corrosion inhibitors combined with hypochlorite sources provide use solutions for effective corrosion inhibition for metal surfaces.

Abstract: A cleaning substrate which comprises at least one layer of a solid hypohalite precipitate, wherein the hypohalite precipitate is formed in situ on the layer of substrate material. A process for making a fibrous cleaning substrate comprising the steps of: a) providing at least one layer of fibrous material; b) exposing the fibrous layer to an aqueous alkaline earth salt solution; c) treating the fibrous layer with a hypochlorite solution; d) allowing the aqueous alkaline earth salt solution combine with the hypochlorite solution to form a solid hypochlorite precipitate around the fibers in the fibrous material and a liquid phase, and e) removing at least 65% of the liquid phase from the fibrous substrate.

Abstract: The present invention provides a method of treating a macrophage related disease comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The present invention also provides a method of modulating macrophage accumulation or activation comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The oxidative agent can be chlorite or a chlorite containing compound.

Abstract: Disclosed are compositions for stabilizing a source of active halogen in aqueous solution. The compositions comprise (i) at least one substituted N-hydrogen compound, such as 5,5-dimethylhydantoin, and (ii) at least one additional nitrogen compound selected from ammonia, ammonium salts, and nitrogen compounds containing no carbon-hydrogen bonds, the molar ratio of (i) and (ii) being in the range of 50:1 to 0.02:1. Active halogen-containing aqueous solutions stabilized by the above compositions are particularly useful for controlling microbial and planktonic growth in aqueous systems such as process liquids in the pulping or papermaking industry. The compositions are also useful in reducing the corrosivity of halogen-containing solutions.

Abstract: This invention relates to methods and compositions for producing an antimicrobial solution with a high weight percent (wt %) conversion of chlorite anion to chlorous acid and/or derivatives of chlorous acid with substantially reduced chlorite residual. Furthermore, the invention presents methods for use of the antimicrobial solution thereby substantially improving the utility and cost effectiveness of chlorous acid solutions. Furthermore, the invention further demonstrates a method for use of a novel antimicrobial solution comprising a brominated derivative of chlorous acid that has substantially reduced volatility and provides at least two different modes of oxidation.

Abstract: The method for surface inclusions detection, enhancement of endothelial and osteoblast cells adhesion and proliferation and sterilization of electropolished and magnetoelectropolished Nitinol implantable medical device surfaces uses an aqueous solution of chemical compounds containing halogenous oxyanions as hypochlorite (ClO?) and hypobromite (BrO?) preferentially 6% sodium hypochlorite (NaClO).

Abstract: The invention relates to the use of a cleaning agent that contains surfactants and has a pH value of at least 11 when diluted in an aqueous solution and ready for use. Said cleaning agent is used to destabilize prions during mechanical and manual cleaning and/or disinfection of medical and/or surgical instruments and appliances. It has been recognized that this combination enables a reliable destabilization of prions during the mechanical reconditioning of surgical instruments.

Abstract: The present invention relates to a method of preparing an intranasal composition including from about 0.0010-0.0040% by weight capsaicin, from about 0.50-0.90% by weight hydroxypropyl methylcellulose, from about 0.010-0.080% by weight n-alkyl dimethyl benzyl ammonium chloride (Quat), and various moisturizing and irrigation agents, wherein the method includes dissolving the above components in water to form an aqueous solution; and filtering the aqueous solution to form an intranasal composition. The present invention further relates to an intranasal drug delivery composition, which includes from about 0.0010-0.0040% by weight capsaicin, from about 0.50-0.90% by weight hydroxypropyl methylcellulose, from about 0.010-0.080% by weight n-alkyl dimethyl benzyl ammonium chloride (Quat), and various moisturizing and irrigation agents.

Abstract: Described herein are chlorite formulations having a pH between about 7 and about 8.5, wherein the chlorite formulations are substantially free of deleterious non-chlorite components. Described herein are chlorite formulations, including pharmaceutical formulations, which are formulated for systemic, parenteral, or intravenous administration. Described herein are methods of preparing and methods of using the chlorite formulations described herein.

Abstract: Described herein are chlorite formulations having a pH between about 7 and about 8.5, wherein the chlorite formulations are substantially free of deleterious non-chlorite components. Described herein are chlorite formulations, including pharmaceutical formulations, which are formulated for systemic, parenteral, or intravenous administration. Described herein are methods of preparing and methods of using the chlorite formulations described herein.

Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid, and wherein the first part, the second part, or both the first and second parts comprise an olefin compound.

Abstract: Described herein are chlorite formulations having a pH between about 7 and about 8.5, wherein the chlorite formulations are substantially free of deleterious non-chlorite components. Described herein are chlorite formulations, including pharmaceutical formulations, which are formulated for systemic, parenteral, or intravenous administration. Described herein are methods of preparing and methods of using the chlorite formulations described herein.

Abstract: The invention relates to an aqueous composition for inactivating sporulated and/or non-sporulated Coccidia parasites comprising 15 to 115 ppm chlorine dioxide and 0.01 to 1 wt-% of an anionic surfactant having one or more C6 to C18 alkyl groups and one or more aryl groups. The invention further relates to a method for preparing the composition and to a method for inactivating sporulated and/or non-sporulated Coccidia by applying the composition.

Abstract: The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.

Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge.

Abstract: This invention relates to antimicrobial composites, films, labelstocks and labels. The antimicrobial composites comprise a mixture of (A) a terpolymer prepared from a mixture comprising (i) an olefin, (ii) at least one copolymerizable comonomer comprising ethylenically unsaturated organic acids or esters, vinyl esters of saturated carboxylic acids and mixtures of two or more thereof, and (iii) carbon monoxide, and (B) an antimicrobial composition which comprises at least one metal chlorite and at least one hydrophilic material capable of reacting with the metal chlorite when exposed to water. The composites which are described herein are useful in preparing films, labelstocks and labels which exhibit the desirable antimicrobial properties by providing a controlled release of chlorine dioxide gas over an extended period of time.

Abstract: A method of stimulating tissue healing in humans or animals includes administering to a human or animal suffering from lesions and infections linked to chronic and/or acute periodontitis a pharmaceutically effective amount of a pharmaceutical composition including (i) at least one sodium halopohalite, and (ii) at least one N-halogenated taurine, wherein halogens from the (i) at least one sodium halopohalite and from the (ii) at least one N-haloamine taurine, which may be the same or different, are selected from the group consisting of fluorine, iodine, bromine and chlorine.

Abstract: A tablet for oral administration comprises a matrix of progressive and continuous released magnesium. For the administration of 90 to 110 parts by weight of magnesium, the matrix comprises 180 to 190 parts by weight of hydroxypropylmethylcellulose, 19.8 to 22.2 parts by weight of glyceryl behenate, 10 to 12 parts by weight of lactose and 10 to 12 parts by weight of colloidal silica. A non-enteric protective coating that slows down the gastric dissolution of the magnesium may comprise 15 to 75 parts by weight of shellac, cellulose ether or a mixture thereof. The tablet may be administered to patients in need thereof.

Abstract: Compositions comprising a mixture of (a) a major amount of solid halogen-containing sanitizer material and (b) a minor amount of calcium oxide modified particulate boric acid, the amount of calcium oxide modified particulate boric acid being sufficient to enable the composition to be classified as a class 1 or class 2 NFPA oxidizer are described. Also described is particulate boric acid at least a portion of the particles thereof having on their surface at least a partial coating of calcium oxide, and a method for preparing such coated particulate boric acid.

Abstract: A method of treating an agricultural-water canal to decompose organic debris in the agricultural-water canal is disclosed. The method provides a controlled delivery of biocide particles to the surface of water by entraining biocide particles in a gaseous stream and then scattering the biocide particles across the surface of the water by propelling the biocide-laden gaseous stream to the surface of the water, whereat the biocide particles are released from the gaseous stream. A device for implementing the method is also disclosed. The device includes a gas blower, a feed hopper and a port which is adapted to direct and propel the biocide-laden gaseous stream to the surface of water in the agricultural-water canal.

Abstract: The invention relates to improved cardioplegia solutions. The invention provides cardioplegia solutions and compositions that produce a readily reversible, rapid electrochemical arrest with minimal tissue ischaemia. The cardioplegia solutions and compositions are used for arresting, protecting and/or preserving organs, in particular the heart during open-heart surgery, transplanting, cardiovascular diagnosis or therapeutic intervention.

Abstract: A method for controlling protozoa trophozoites and cysts wherein one or more biocides or non-biocidal agents are encapsulated within a micro-capsule or nano-capsule and then introduced into an aqueous system. The micro-capsule or nano-capsule has an exterior composition adapted for digestion by the protozoa. A vesicle for controlling protozoa trophozoites and cysts is also provided.

Abstract: A therapeutic agent for infectious skin and mucosal diseases to be applied to an infected area for ameliorating a symptom of the infected area caused by infection with a pathogenic microorganism includes: a chlorine dioxide solution including a dissolved chlorine dioxide gas.

Abstract: A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms.

Abstract: The present invention provides a solid-layered composition having at least two parts. The first part comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a functional ingredient, b) a builder or filler, and c) wherein the second part does not contain any oxidant.

Abstract: Described are compositions containing a mixture of (a) particulate calcium hypochlorite and (b) an amount of aluminum hydroxide that is sufficient to increase the UN-burn time of the composition by a factor of at least 2.5 compared to that of the calcium hypochlorite, the composition having an available chlorine content of at least 35 weight percent. Further described are solid compositions of (a) granular calcium hypochlorite having a UN Packing Group oxidizer classification of II, and (b) an amount of aluminum hydroxide such that the composition is classified as a Packing Group III Division 5.1 oxidizer or as a non-Division 5.1 oxidizer, the composition having an available chlorine content of at least 40 weight percent. Further described are formed articles prepared from the above-described compositions.

Abstract: A method for reducing pathogens in the gastrointestinal tract of a live animal comprising orally administering to the animal an effective amount of an aqueous antimicrobial solution, wherein the aqueous antimicrobial solution comprises from about 0.01% to about 0.1% by weight of a metal chlorite and a sufficient quantity of an acid having a first pKa of from about 2.0 to about 4.4 to adjust the pH of the aqueous antimicrobial solution to about 2.2 to about 4.5 and to maintain the chlorite ion concentration in the form of chlorous acid to not more than about 35% by weight of the total chlorite ion present in the aqueous antimicrobial solution, is disclosed.

Abstract: An antimicrobial coating composition consisting essentially of 70 to 80 wt. percent water; 5 to 10 wt. percent methyl alcohol; 3 to 8 wt. percent octadecyl dimethyl trimethoxy silylpropyl-ammonium chloride; 1 to 5 wt. percent chloropropyl trimethoxysilane; 0.5 to 1.5 wt. percent aminopropyltrialkoxysilane; 0.5 to 1.5 wt. percent of a surfactant; 1 to 1.5 wt. percent of an anti-microbial agent; and 0.5 to 2.5 wt. percent sulfuric acid.

Abstract: The present invention provides a photosensitising composition comprising a mixture of at least one oxygen carrier, at least one oxidising agent and at least one surfactant, and its uses. The ratio of the at least one oxygen carrier to the at least one oxidising agent to the at least one surfactant may be in the range of 50:40:10 to 80:19.8:0.2. The photosensitising composition may be used for treating and/or preventing conditions caused by microorganisms.

Abstract: A solid composition including calcium and/or magnesium hypochlorite, a builder (e.g., one or more of carbonate, bicarbonate, sesquicarbonate), an acid, a water-soluble polymer, at least one anionic surfactant, and optionally, a hydrotrope. The composition does not include any potassium hypochlorite, sodium hypochlorite, lithium hypochlorite, N-halogenated compounds, peroxides, persulfates, hydantoins, isocyanurates, or carboxylic acids that also have hydroxyl, amino, amido, imino, or imido groups. Upon dissolution of the composition in water, the calcium and/or magnesium hypochlorite and acid react to form hypochlorous acid. The use of hypochlorous acid, rather than direct use of an alkaline or alkaline earth hypochlorite results in a composition that is typically acidic rather than basic, and that results in improved cleaning. The composition is particularly suited for cleaning and disinfecting dentures.

Abstract: A fast-acting solid composition in the form of a tablet that generates and releases a biocidal solution comprising at least chlorine dioxide with an enhanced weight percent yield of at least 20 wt % is presented. The composition comprises reactants capable of in-situ generation of chlorine dioxide comprising a chlorite donor that is coated with a non-hygroscopic material that enhances the environmental stability of the composition.

Abstract: A method of stimulating tissue healing in humans or animals includes administering to a human or animal a pharmaceutically effective amount of a pharmaceutical composition which includes (i) at least one halogenated compound, and (ii) at least one N-halogenated derivative of at least one compound selected from zwitterionic compounds and/or amino acids or their derivatives.

Abstract: There are provided a chlorine dioxide solution composition whose solute includes dissolved chlorine dioxide and chlorite; and a solution composition encapsulating body including a glass vessel or enameled vessel and the chlorine dioxide solution composition hermetically sealed therein.

Abstract: The present application discloses a method of treating or preventing an infection of a nail, claw, hoof, or skin comprising administering a pharmaceutically acceptable formulation comprising hypohalite and a formulating agent to a subject in need thereof, and compositions thereof.

Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

Abstract: The present invention relates to a method of treating an outer eye disorder selected from a cataract, neovascularization, keratitis, epithelium deficiency, or chronic opacity, by administering to the eye a composition comprising acidic electrolytic water. The present invention also relates to a stable acidic electrolyzed oxidizing water characterized by low conductivity, the presence of dissolved chlorine gas (Cl2), hypochlorous acid (HOCl) and chloride ions (Cl?), and by the presence of negligible quantities of hypochlorite ion (OCl?).

Abstract: A biocide is formed by mixing at least one of ammonium sulfamate and ammonium carbamate with an aqueous solution of a hypochlorite oxidant at a molar ratio of ammonium to hypochlorite of at least 1:1. The biocide is useful in treating microbial or biofilm growth, pulp and paper process water, cooling tower water, waste water, reclaimed waste water, sludge, colloidal suspensions, irrigation water or a medium having a reducing capacity.