Abstract: A functional consumable composition for promoting skin health may comprise, for each 100% by dry weight, no more than about 0.2% by dry weight catechin and no more than about 2% by dry weight amino acid. The amino acid may comprise at least one of 1-proline and 1-arginine, and the weight % 1-proline to weight % 1-arginine may be greater than about 2. Another functional consumable composition may comprise no more than about 0.2% by dry weight catechin and at least one of lipoic acid, selenium, vitamin E, vitamin B, and vitamin C. A source of the catechin may comprise at least one of white tea solids and epigallocatechin gallate extract. Methods for using such functional consumable compositions are also described.
Abstract: The present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity and related conditions. In particular, the present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity through measuring aberrant red blood cell based potassium efflux levels. In addition, the present invention provides methods for treating conditions involving salt sensitivity (e.g., hypertension), preventing the onset of conditions involving salt sensitivity, identifying individuals at risk for developing salt sensitivity and related conditions, identifying new types of treatment for salt sensitivity and related conditions, and evaluating the effectiveness of treatments for conditions involving salt sensitivity (e.g., hypertension).
Type:
Application
Filed:
January 17, 2008
Publication date:
February 11, 2010
Applicant:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Abstract: The present invention has its object to provide a safer and highly effective composition capable of relieving or preventing xerostomia. The present invention relates to an agent for relieving or preventing xerostomia comprising an oxidized coenzyme Q and/or a reduced coenzyme Q as active ingredients, a composition containing the agent for relieving or preventing xerostomia in a form of a food product, a health food, a dietary supplement, a supplement, an oral health care product, a medicament, a quasi drug, a pet food, a feed or the like, and a method for treating xerostomia and a method for reducing risks of xerostomia comprising administering the composition.
Abstract: The present invention discloses a compound preparation for quickly reducing oxidative stress, which contains small molecules and mineral trace elements that can remove or help removing free radicals, can regulate the function of endocrine and circulatory digestive system, as well as other components that can rebuild inner harmony. The compound preparation is in solid dosage form, preferably effervescent tablet or effervescent granules. The preparative method of the compound preparation is also disclosed. Animal experiment and clinical trial show that the invention has strong effect in reducing oxidative stress and disease prevention.
Type:
Application
Filed:
April 23, 2007
Publication date:
January 21, 2010
Applicant:
Sino-US PFICKER PHARMACEUTICALS LTD.
Inventors:
Hongping Yie, Meg M. Sun, Zuolin Zhu, Wei Sun, Zhongquan Zhao, Jinyuan Wang, Feng Zheng
Abstract: The invention concerns the use of at least a molecule containing selenium, in an amount corresponding to a daily dose of about 2 to 40 mg, even 80 mg of atomic selenium equivalent, on its own or combined with other synergetic molecules for controlling oxidative stress and excessive inflammatory reaction: zinc, vitamin E, vitamin C, iron binder, glutathione precursor, copper and/or copper input binder, for preparing a medicine for treating severe systemic inflammatory response syndrome, in particular any acute infectious condition endangering the patient's life whether of bacterial, parasitic, fungal or viral origin, and any condition corresponding to a severe onset of inflammatory pathology bringing about an exacerbation of cytokine secretion. The invention is applicable in human and veterinary medicine.
Abstract: A composition for use in treating or preventing a respiratory virus which comprises: (a) at least one water soluble zinc, copper, selenium and/or manganese compound able in aqueous solution to dissociate into zinc, copper selenium and/or manganese ions; (b) at least one water soluble ammonium agent able in aqueous solution to dissociate into ammonium ions (c) at least one acid, and (d) water.
Abstract: The present invention relates generally to a method of treatment and in particular a method of treating a subject exhibiting symptoms of kidney failure or are at risk of developing same.
Abstract: Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer. The inventive products can be used for dissolving fats, peptides, resins, and all types of resinous materials, removing fats, peptides, resins, and all types of resinous materials from surfaces, cleaning, and lubricating, according to the solubilized active substances used.
Abstract: Methods for treating feline hyperthyroidism comprising (1) administering to a feline an antithyroid agent in conjunction with feeding the feline a composition comprising from about 0.1 to less than about 1 mg/kg iodine or (2) feeding the feline a composition comprising from about 0.1 to less than about 1 mg/kg selenium on a dry matter basis.
Type:
Application
Filed:
January 26, 2007
Publication date:
September 10, 2009
Applicant:
HILL's PET NUTRITION INC
Inventors:
Karen Joy Wedekind, Dale Allen Fritsch, Chadwick Everett Dodd, Timothy Arthur Allen
Abstract: The invention provides a nutritional supplement system and program for patients undergoing or who have undergone a surgical or other invasive or stressful procedure, or who have suffered an injury. This nutritional supplement for the peri-operative period is designed to prevent deficiencies of nutrients needed for optimal health and healing during this period or for general application and to enable the person receiving the nutritional supplementation to achieve maximum healing and rapid recovery from a procedure or injury.
Abstract: The formulation provides a method of treating headaches, neck, joint and inflammatory-type pain in a mammalian subject by administering to the subject a therapeutically effective amount of a nitrate-containing compound and a therapeutically effective amount of a selenium-containing compound. The formulation also provides kits and systems for practicing the subject methods.
Type:
Application
Filed:
January 24, 2008
Publication date:
July 30, 2009
Inventors:
Bryan Todd Oronsky, Neil Charles Oronsky
Abstract: The present invention relates to the use of selenate or a pharmaceutically acceptable salt thereof in methods and compositions for enhancing the activity of the protein phosphatase PP2A. Methods of reducing phosphorylation of tau protein, inhibiting activity of GSK3 and treating or preventing neurodegenerative diseases are also described.
Abstract: A Phytoceutical composition for the prevention and treatment of weight disorders and symptoms is provided. A specific combination of extracts of plants and nutraceuticals is provided, based on categorizing plants and nutraceuticals into one of three groups, Energy, Bio-Intelligence, and Organization. Such combinations have synergistic effects, with minimal side effects.
Abstract: Metallo-proteins including but not limited to lactoferrin (LF), transferrin (TF) and ovotransferrin (OTF) (all members of transferrin family), ceruloplasmin (CP) and metallo-thionein (MT) were found to stabilize and enhance the bio-functional activity of tocotrienol (T3), T3 mixtures or derivates. The synergism between MP and T3 also promote the intestinal transfer and the ultimate bio-availability of T3 and T3-derivatives for physiological functions. Such functional synergism includes hypocholesterolemic, anti-thrombotic, antioxidant, anti-athermogenic, anti-inflammatory and immuno-regulatory activities of T3 agents. These T3 compositions are useful as pharmaceuticals, in cosmetics, in foods and as nutritional supplements.
Type:
Application
Filed:
December 3, 2008
Publication date:
June 11, 2009
Applicant:
Naidu LP
Inventors:
A. Satyanarayan Naidu, A.G. Sreus Naidu
Abstract: The use of docosahexaenoic acid in the manufacture of a composition for administration to a pregnant woman for reducing the risk of development of overweight or obesity of the baby in infancy and/or early childhood.
Abstract: A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.
Abstract: HIV-1 is a slow virus that has a genome that requires the removal of glutathione, glutathione peroxidase and of selenium, cysteine, glutamine and tryptophan from its host as it is replicated. Although various clinical trials have improved the health of AIDS patients by correcting one or more of these nutritional deficiencies, they have never been addressed together. The current invention combines selenium, cysteine, tryptophan, and glutamine in powder, capsule, or pill form for the creation of glutathione and glutathione peroxidasae by the patient and the correction of deficiencies of other biochemical substances that require selenium, cysteine, tryptophan, and glutamine as precursors. Such a treatment protocol will prevent HIV-1 seropositive individuals from developing AIDS and reverse most of the symptoms of AIDS in those with this disorder.
Abstract: The invention relates to medicine, in particular to pharmacology, and is embodied in the form of an agent for limiting neuro-mediator, neuro-endocrine and metabolic disturbances generating the disorders of a central nervous system and functional somatic disorders. The inventive agent is based on a DSIP (delta sleep inducing peptide) or a derivative chemically related thereto and can be used for correcting and preventing functional shifts in a central nervous system and concomitant somatic disorders caused by unfavourable and extreme environmental factors and different pathological conditions of an organism or during the ageing thereof.
Type:
Application
Filed:
August 23, 2006
Publication date:
April 16, 2009
Inventors:
Inesa Ivanovna Mikhaleva, Vadim Tikhonovich Ivanov, Igor Arkadjevich Prudchenko, Boris Olegovich Voitenkov
Abstract: A method of increasing pregnancy rate in a female subject is provided, the female subject or an oocyte for introduction into the female subject being fertilized by a sperm from a male subject. The method includes the steps of administering to the male subject prior to fertilization: (i) an effective amount of an anti-oxidant agent; and (ii) an effective amount of an agent that reduces inflammation in the male reproductive tract and/or an effective amount of an agent that increases testicular testosterone concentration.
Abstract: Provided, among other things, is a delivery module for a non-greasy, non-irritating selenium sulfide composition comprising: (A) an aerosol delivery device; (B) within the aerosol delivery device, the selenium sulfide composition comprising an effective amount of selenium sulfide that is 1% or more by weight of the composition, and a frothing agent, wherein the selenium sulfide composition has a viscosity low enough to support aerosol delivery and the selenium sulfide composition is effective to form a foam upon propellant-driven aerosol delivery; and (C) within the aerosol delivery device, a propellant.
Abstract: Combinations of a polyunsaturated fatty acid and diindolylmethane and pharmaceutical composition containing such combinations. Further provided are combinations including a polyunsaturated fatty acid, diindolylmethane, and folic acid. Also provided are combinations including diindolylmethane and folic acid. Also provided is a method for increasing the number of normal cells and decreasing the number of aberrant cells in a subject having the steps of administering to the subject a combination comprising a polyunsaturated fatty acid and diindolylmethane.
Abstract: The invention discloses a pharmaceutical composition useful for treatment and prevention of medical disorders and ailments. The aforesaid composition comprises active ingredients comprising; Turmeric extract, Turmeric powder, optionally, Selenium or source of Selenium, especially Selenomethionine, optionally, Green tea extract. The pharmaceutical composition further comprises enteric coating encapsulating the same. The disclosed pharmaceutical composition is especially adapted for treatment of inflammatory bowel disease (IBD) and colorectal cancer (CRC).
Abstract: Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate, glucosamine, and/or methylsulfonylmethane. A representative method for reducing muscle and joint soreness includes administering the chemical formulation to a host.
Abstract: The formulation provides for the treatment and prevention of fibromyalgia, depression and other muscle and nervous system disorders. The formulation combines Coenzyme Q10, vitamin B1, 5-Hydroxytryptophan, magnesium, Vitamin D, Vitamin C, Selenium and Zinc. Each component has an effect on its own combined with a synergistic effect with other components.
Abstract: The invention concerns a composition containing red yeast rice and other components, as a chemopreventative agent to reduce the risk of cancer.
Abstract: Assays are preformed to determine nutrient deficiency levels in an individual to address the deficiencies and improve health and longevity. Nutraceutical and cosmeceutical products containing nanoencapsulated active ingredients are provided, in addition to dietary, exercise, sleep, and other lifestyle recommendations.
Abstract: A method of providing controlled release of a biologically active substance within a subject's digestive system. The biologically active substance is administered concurrently with one or more soluble fibers in an oral dosage unit. The soluble fibers interact with the biologically active substance within the subject's digestive system to moderate and control the release of the biologically active substances in the subject's bloodstream. This provides more constant blood concentrations of the biologically active substances. The amount of soluble fibers in the oral dosage unit is greater than 40% by weight, and in some cases greater than 50% by weight of the oral dosage unit. The oral dosage unit typically contains from about 1 to 15g of soluble fiber, and in some cases from about 3 to 5g of soluble fiber. The biologically active substance may contain phytonutrients that promote the subject's cardiovascular system, immune system, or weight management.
Type:
Application
Filed:
June 7, 2007
Publication date:
December 11, 2008
Applicant:
UNICITY INTERNATIONAL, INC.
Inventors:
Peter J. E. Verdegem, Stewart F. Hughes, Curtis A. Hedges, G. Paulo Bangerter
Abstract: The present invention relates to the use of a combination of group B vitamins, trace element(s), at least one oil comprising essential ?-3 and/or ?-6 fatty acids and an excipient suitable for oral administration, for use in the simultaneous treatment of excess weight and slackening of the skin localized in the same area. The invention also relates to a corresponding food supplement.
Type:
Application
Filed:
December 15, 2006
Publication date:
November 27, 2008
Inventors:
Philippe Msika, Nathalie Piccardi, Pascale Cochet, Michel Moreau
Abstract: The present invention relates to compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment). For example, the present invention provides compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same for treating and/or preventing one or more conditions (e.g., problems) disorders, and/or diseases related to establishing and/or maintaining a pregnancy. Compositions and methods of the present invention find use in, among other things, research and clinical (e.g., preventative and therapeutic) applications.
Abstract: Described herein are combination methods, compositions and therapies for treating ophthalmic conditions or diseases arising from, associated with or leading to the overproduction of waste products in the visual cycle. Agents included within these combinations are 13-cis-retinyl derivatives; other agents included within these combinations are selected from vitamins, antioxidants, minerals, inducers of nitric oxide production, anti-inflammatory agents, and negatively-charged phospholipids. Such combination methods may be used as single or multiple administration therapies, or in combination with other agents or therapies.
Abstract: Disclosed is a method of enhancing absorption (pinocytosis efficiecy) of immunoglobulins administered to postnatal domestic mammals (e.g., bovine) by using selenium. As an example of a selenium compound added, sodium selenite is particularly effective.
Abstract: A method of treating neurotransmitter dysfunction in a patient. The method includes the step of administering an amino acid precursor of a catecholamine in a balanced and effective therapeutic range. The catecholamine precursor is preferably L-dopa, but may alternatively be tyrosine, D,L-Phenylalanine or an active isomer thereof, and N-acetyl-L-tyrosine or other amino acid precursor of L-dopa. An amino acid precursor of serotonin in an effective therapeutic range, is also administered. The serotonin precursor is preferably 5-HTP, but may alternatively be tryptophan. At least one cofactor is also preferably administered. Cofactor options include Vitamin B6, Vitamin C, Calcium, Folate, and Cysteine. A method of periodic administration and patient checking is also disclosed.
Abstract: The present invention relates to a combined preparation comprising the active substance corticoid and a selenium-containing active substance. The combination of active substances leads to a clear reduction of the mortality rate of sepsis patients.
Abstract: A composition based on labdane-diterpenoids that provides better photo protection against both UV A and UV B radiations in the HaCaT human keratinocyte cell lines is disclosed. The composition comprises 8,13-epoxy-1?,6?,7?,9?-tetrahydroxylabd-14-en-11-one alone and in combination with 6?-acetoxy-8,13-epoxy-1?,7?,9?-trihydroxylabd-14-en-11-one and/or 7?-acetoxy-8,13-epoxy-1?,6?,9?-trihydroxylabd-14-en-11-one. The composition protects the cells of the skin from harmful UV A and UV B rays through synergistic mechanisms with utility as a safe long-term cosmetic solution for preventing UV-induced skin damage and to induce sunless tanning. Additionally, the composition enhances melanogenesis in B16F1 mouse melanoma cells acting as tanning inducers/accelerators both in the presence or absence of sunlight. Elevation of melanogenesis confers additional protection against UV-induced skin damage.
Abstract: A composition including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The composition can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient, is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The composition can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve plasma concentrations of antioxidant nutrients, and increase the activity of genetic mechanisms for DNA repair and stability.
Type:
Application
Filed:
March 31, 2008
Publication date:
September 18, 2008
Applicant:
ACCESS BUSINESS GROUP INTERNATIONAL LLC
Inventors:
Ruo G. HUANG, Stephen R. MISSLER, Marc J.P. LEMAY, Edward S. KAHLER, Donald J. PUSATERI, Haeri ROH-SCHMIDT, Shyam RAMAKRISHNAN
Abstract: A method for the treatment and/or prophylaxis of disorders of the gastrointestinal system, other disorders selected from post exercise recovery, heat stress, vasovagal states, sleep disorders and fluid loss, and for the maintenance of blood sugar level homeostasis, comprising orally administering to said patient an admixture of vitamins and minerals formulated to have a pH greater than or equal to 5.0 in aqueous solution.
Abstract: A natural remedy-dietary supplement combination product which comprises omega-3 fatty acids, ?-tocopherol, ascorbic acid, selenium, Harpagophytum procumbens (devil's claw) and Boswellia serrata or carterii (frankincense), with the proviso that it does not comprise a plant or plant extract of the Saxifragaceae family, and a method of treating a chronic inflammatory disorder and/or a rheumatic disorder.
Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
Type:
Application
Filed:
January 31, 2008
Publication date:
August 21, 2008
Applicant:
IKARIA HOLDINGS
Inventors:
Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
Abstract: The present invention relates to dosage forms for oral administration of therapeutic formulations, adapted to provide immediate and/or sustained-release of therapeutic substances, particularly for oral administration of vitamins. There is provided a dosage form for oral administration of a vitamin, comprising: a liquid phase containing a vitamin, e.g. Vitamin C in a relatively fast release form and optionally a solid phase suspended in the liquid phase and containing a vitamin e.g. Vitamin C in a relatively slow release form.
Type:
Application
Filed:
April 6, 2006
Publication date:
August 14, 2008
Inventors:
Stefan Heim, Martina Birgit Schmid, Christoph Walter Theurer
Abstract: The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
Type:
Application
Filed:
October 5, 2007
Publication date:
August 7, 2008
Applicant:
IKARIA, INC.
Inventors:
Kevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
Abstract: A composition and method for oral application to mouth tissue to reduce the symptoms of herpes simplex virus infection, said composition comprising an anti-viral agent, an antioxidant agent, an analgesic agent and a flavorant.
Abstract: New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
Abstract: Mineral additives for preparing tablet compositions that comprise Vitamin E and optionally saw palmetto. The compositions are preferably formulated with a zinc compound and a selenium compound.
Abstract: The invention may be summarized as follows. A combination to be parenterally delivered to a critically ill patient or for the purpose of improving mitochondrial function. The combination comprises a glutamine precursor molecule and an antioxidant in sufficient concentrations to be clinically effective. The combination may be prepared in the absence of lipids or carbohydrates. The combination may be prepared in small volumes to benefit volume restricted patients. A composition, or a unit dosage form comprising the combination and methods of administering the combination, composition or unit dosage form are also provided.
Abstract: A composition and method for treatment of viral-induced skin lesions, such as warts, are described. The composition is comprised of tea tree oil and/or derivatives from tea tree oil and one or more minerals, such as iodide and/or selenium. The composition is used to prepare medicaments for the treatment of viral-induced lesions, such as warts caused by the Molluscum contagiosum virus, human papillomavirus, and/or herpes simplex virus. The composition is applied topically to the human epidermis and/or to the genital tract as needed.
Abstract: Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for minimizing said damage which comprise administering to subjects in need thereof a therapeutic amount of a formulation(s) according to the invention.
Type:
Application
Filed:
November 20, 2007
Publication date:
May 22, 2008
Inventors:
Kedar N. Prasad, William C. Cole, Gerald M. Haase
Abstract: A natural composition formulated to modulate multiple pathophysiological processes in order to facilitate homeostatic glucose metabolism in a patient, and more particularly to increase insulin sensitivity in the same. The natural composition is a safe and effective formulation for the etiological prevention and treatment of diseases, complications, conditions, or disorders associated with chronic or long-term destabilization of glucose metabolism.
Abstract: The field of invention relates to Vitamin C compositions, and in particular to Vitamin C compositions containing ascorbate-glucose transport enhancers. In at least one aspect, a composition is provided herein that includes ascorbate in an amount from about 0.1% by weight of actives to about 99.9% by weight of actives, and at least one ascorbate-glucose transport enhancer in an amount from about 0.01% by weight of actives to about 99.0% by weight of actives. In another aspect, a method of improving the transport of ascorbate into cells and tissues is provided that includes providing a composition comprising ascorbate and at least one ascorbate-glucose transport enhancer.
Abstract: The present invention discloses the use of selenate or its pharmaceutically acceptable salts, especially in supranutritional amounts, in methods and compositions for inhibiting the growth or proliferation of tumor cells. The present invention also discloses the use of selenate or its pharmaceutically acceptable salts in combination with one or both of a hormone ablation therapy and a cytostatic agent or cytotoxic agent, for inhibiting the growth or proliferation of tumor cells. In certain embodiments, the methods of the invention are useful for treating or preventing cancers, especially cancers in which the Akt signaling pathway is activated, such as prostate cancer. Additionally, the present invention discloses the use of selenate or its pharmaceutically acceptable salts in combination with a hormone-ablation therapy and optionally a cytostatic agent or cytotoxic agent in methods and compositions for treating hormone- dependent cancers.
Type:
Application
Filed:
January 31, 2005
Publication date:
April 3, 2008
Applicant:
Velacor Therapeutics Pty. Ltd.
Inventors:
Niall Corcoran, Christopher Hovens, Anthony Costello