Skin Burn Or Open Wound Treatment Patents (Class 424/78.06)
  • Patent number: 10426803
    Abstract: A composition and method for treating Epidermolisis bullosa (EB), comprising: applying to skin or mucosal surfaces of a patient in need of treatment for EB a dressing gauze or bandage without prior cleaning of said skin or mucosal surfaces, wherein distributed on said dressing is an effective amount of a composition containing beeswax; an oleaginous base, vitamins and a pharmaceutically acceptable excipient; then removing said dressing at least twice per day without damaging the patient's skin or mucosal surfaces due to removal of the dressing.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: October 1, 2019
    Assignee: REV PHARMA CORP
    Inventor: Efrain Ramon Vasquez
  • Patent number: 10278870
    Abstract: A system for treating a tissue site includes a reduced-pressure source to apply reduced pressure, a manifold in fluid communication with the pressure source to provide reduced pressure to the tissue site, and a drape for adhering to the tissue site to cover the tissue site and the manifold. The drape includes an adhesive layer for sealing the drape to the tissue site to create a sealed space having the manifold therein, and a non-adhesive layer formed from a portion of the adhesive layer. A method for manufacturing a medical drape includes providing a sheet of adhesive material and treating a side of the sheet of adhesive material to form a non-adhesive layer and an adhesive layer. The method laminates a release liner adjacent the adhesive layer.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 7, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Timothy Mark Robinson, Christopher Brian Locke
  • Patent number: 10159593
    Abstract: A medical bandaging product that includes a flexible medical material including an elongate fabric, a reactive system, and microspheres. In certain aspects, a component of the reactive system is homogeneously impregnated into or coated throughout the flexible medical material without being encapsulated in the microspheres such that the reactive system remains stable and non-activated in the absence of an activating agent, and hardens upon activation by exposure to the activating agent to form a rigid, self-supporting structure. In this aspect, the microspheres are homogeneously impregnated into or coated throughout the flexible medical material, the microspheres encapsulate an activating agent and are configured to release the activating agent to form the rigid, self-supporting structure.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 25, 2018
    Assignee: BSN MEDICAL, INC.
    Inventor: John C. Evans
  • Patent number: 9757492
    Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: September 12, 2017
    Assignee: Adhesys Medical GmbH
    Inventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
  • Patent number: 9487558
    Abstract: Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (MPKEKVFLKIEKMGRNIRN) (SEQ ID NO: 10), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN) (SEQ ID NO: 10), namely EKMGRN (SEQ ID NO: 1). The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107 (SEQ ID NO: 10), and thus represent a less expensive, more versatile means for developing effective therapies.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: November 8, 2016
    Assignee: HELIX BIOMEDIX INC.
    Inventors: Lijuan Zhang, Robin Carmichael
  • Patent number: 9457123
    Abstract: An adhesive hydrogel dressing as well as methods of applying the dressing to a patient. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. A release element is in contact with at least a portion of the edge of the hydrogel pad proximate the area that the hydrogel pad and release liner separate during liner removal.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: October 4, 2016
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: David R. Holm, Scott A. Burton, Robert A. Asmus, Richard L. Jacobson
  • Patent number: 9457062
    Abstract: The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: October 4, 2016
    Assignee: CBIO LIMITED
    Inventors: Barbara J. Johnson, Caroline A. Dobbin, Dean J. Naylor, Linda A. Ward, Inge E. A. Flesch, Christopher B. Howard
  • Patent number: 9415002
    Abstract: A polysilicone base for medical and cosmetic compositions includes a dimethicone fluid, a volatile cyclosiloxane, a silicone elastomer, and nanoparticulate silica. The polysilicone base may also include one or more therapeutic agents for reducing the formation and appearance of scar tissue at the site of a wound. The polysilicone base is spreadable, but does not run off of the wound site. The polysilicone base is phase-stable, in that it does not separate into phases.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: August 16, 2016
    Assignee: Englewood Lab, LLC
    Inventors: Julio Lamberty, Yi-Chun Lin
  • Patent number: 9254133
    Abstract: Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: February 9, 2016
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr.
  • Patent number: 9090670
    Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 28, 2015
    Assignee: Rapid Pathogen Screening, Inc.
    Inventors: Johannes Gerhardus Maria Bolscher, Arie van Nieuw Amerongen, Engelmundus Cornelis Ignatius Veerman, Menno Johannes Oudhoff, Willem van't Hof, Kamran Nazmi, Petronella Adriana Maria van den Keijbus
  • Publication number: 20150139933
    Abstract: A method for the polymerization of ?-lipoic acid and ?-lipoic acid derivatives includes preparing an ?-lipoic formulation, exposing the ?-lipoic formulation to an aqueous phase and a gaseous phase at a gas/water interface, and allowing the ?-lipoic formulation to polymerize at the gas/water interface to form a poly(?-lipoic acid) polymer. The ?-lipoic formulation can be an ?-lipoic solution of an ?-lipoic solute and an organic solvent miscible with water, and can also be an ?-lipoic acid or oligomer or polymer thereof in liquid (typically melt) form.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 21, 2015
    Inventors: Judit E. Puskas, Emily Q. Rosenthal-Kim
  • Patent number: 9033959
    Abstract: A skin graft applicator with a handle member and a roller member is described for use in applying a skin graft to a patient. The skin graft applicator has a manipulator pad for positioning the skin graft, and a roller member for forcing air and fluid from underneath the skin graft ensuring the proper bond between graft and tissue.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: May 19, 2015
    Assignee: Mercy Health System, Inc.
    Inventor: Bharat Shah
  • Patent number: 9005662
    Abstract: An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: April 14, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Joseph B. Schlenoff
  • Publication number: 20150096503
    Abstract: A method of treating a hoof of an ungulate animal. The method comprises coating one or both of (i) at least a portion of a bottom surface of the hoof or (ii) at least a portion of a block surface with a curable polymer and allowing the polymer to cure for a period of time. The polymer is cured within 60 seconds or less of the coating and the cured polymer has a Shore D hardness of about 10 to about 50. The curable polymer is provided as a two component system. The first component is a reaction product of (a) comprises 4-4?-diphenylmethane-diisocyanate, castor oil, isocyanatopropyltriethoxysilane, and glycidoxypropyltrimethoxysilane, and wherein (b) comprises dicyclohexylmethane-4,4-diisocyanate, polyether polyol, 4,4?-diphenylmethane-diisocyanate (MDI), and triethoxy(3-isocyanatopropyle)silane. The second component comprises polyoxypropylene oxide ether polyol, diol (2000 MW), polyxoypropylene oxide ether polyol, triol (450 MW), tetrahydroxypropylethylendiamine, metaxylenediamine, and organobismuth catalyst.
    Type: Application
    Filed: October 4, 2013
    Publication date: April 9, 2015
    Applicant: Vettec, Inc.
    Inventors: Frank Dugan, Frank Rovelli, Paul Wittrock
  • Publication number: 20150096912
    Abstract: A solid wound dressing material comprising: at least about 5 wt % collagen; from about 6 wt % to about 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and from 0 wt % to about 20 wt % water; wherein the weight percentages are based on the dry weight of the composition. Also provided are methods of making such materials, and wound dressings comprising such materials. In another aspect the invention provides a solid wound dressing material comprising: at least about 5 wt % collagen; from about 10 wt % to about 90 wt % Cadexomer iodine; and from 0 wt % to about 20 wt % water, wherein the weight percentages are based on the dry weight of the composition. Also provided are wound dressings comprising the materials.
    Type: Application
    Filed: May 1, 2013
    Publication date: April 9, 2015
    Applicant: Systagenix Wound Management (US), Inc.
    Inventor: Lorna McInroy
  • Patent number: 8999297
    Abstract: A generally non-acidic hemostatic agent, having a relatively neutral pH comprising a magnesium compound, such as a magnesium chloride, a magnesium sulfate and/or a magnesium acetate based compound. The resultant agent is generally less caustic than previous agents, when using a similar amount of active material.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: April 7, 2015
    Assignee: Inter-Med, Inc.
    Inventors: Gary J. Pond, John Baeten
  • Patent number: 8999314
    Abstract: Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: April 7, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Pappachan E. Kolattukudy, Jianli Niu
  • Patent number: 8987339
    Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 24, 2015
    Assignee: Medicus Biosciences LLC
    Inventors: Syed H. Askari, Yeon S. Choi
  • Patent number: 8979726
    Abstract: A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 17, 2015
    Assignee: Biolife, L.L.C.
    Inventors: John Hen, Talmadge Kelly Keene, Mark Travi
  • Publication number: 20150071869
    Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Sheng Zhang, Rafael Ruiz, SR.
  • Publication number: 20150064129
    Abstract: The invention discloses a composition comprising hyaluronic acid with a high molecular weight and povidone-iodine in low amount that has advantageous efficacy in enhancing wound healing and maintains high stability. Also disclosed is a method of using the composition of the invention in healing wounds.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 5, 2015
    Applicant: TAIWAN BIOTECH CO., LTD.
    Inventors: LiChin Lin, YuKao Cheng, YuHua Chen, ShuFang Chiang
  • Patent number: 8968710
    Abstract: A topical anesthetic is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the skin or mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle also includes propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 3, 2015
    Inventors: Alan J. Wickenhauser, Stephen E. Peipert
  • Publication number: 20140377211
    Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
    Type: Application
    Filed: September 9, 2014
    Publication date: December 25, 2014
    Applicant: POLY-MED, INC.
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich
  • Patent number: 8916143
    Abstract: The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: December 23, 2014
    Assignee: Cornell University
    Inventors: David Putnam, Peter Zaweneh, Jason Spector
  • Publication number: 20140370075
    Abstract: Reinforced, laminated, impregnated, and materials with composite properties as cross linked polyvinyl alcohol hydrogel structures in bulk or cellular matrix forms that can take essentially any physical shape, or can have essentially any size, degree of porosity and surface texture. They have a wide range of physical properties, unusual and unique combinations of physical properties and unique responses to stress fields, which allows for their use in many end use applications.
    Type: Application
    Filed: August 21, 2014
    Publication date: December 18, 2014
    Inventor: Nedeljko Vladimira Gvozdic
  • Publication number: 20140369952
    Abstract: A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.
    Type: Application
    Filed: October 31, 2012
    Publication date: December 18, 2014
    Inventors: Keliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
  • Publication number: 20140348774
    Abstract: The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection.
    Type: Application
    Filed: June 9, 2014
    Publication date: November 27, 2014
    Applicant: Aurora Pharmaceutical, LLC
    Inventors: Michael Strobel, Gene Komer
  • Publication number: 20140348775
    Abstract: [Problems] The objective is to provide a new low-toxic drug for external use for intractable diseases, such as erosion, decubitus, and skin ulcer, that prevents cicatrization and reduces iodine accumulation on wound surfaces with sufficiently promoting healing. [Means for solving problem] Preparation of a wound treatment drug for external use containing oily bases and iodine but substantially no white soft sugar, which is a characteristic of the drug of this invention. The invented drug prevents infection through the wound surface due to a sufficient bactericidal effect of iodine, and promotes wound healing, prevents cicatrization and reduces iodine accumulation on the wound surface by maintenance of appropriate moisture in the wound surface due to a moisturizing effect of oily bases.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Inventors: Hitoshi MIZUTANI, Yoshiaki MIYAMOTO, Atsushi NISHIKAWA
  • Patent number: 8895542
    Abstract: Disclosed is a medicinal cream that includes flisidic acid which is made in situ under an oxygen-free environment using sodium fusidate. The fusidic acid is made by dissolving the sodium fusidate in a co-solvent under inert gas purging and under vacuum, and converting the sodium fusidate to fusidic acid in situ by adding an acid under stirring, The disclosed medicinal cream also includes a biopolymer and a cream base comprising at least one of each of a primary and secondary emulsifier, a waxy material, and water.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: November 25, 2014
    Inventors: Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Kuppusamy Senthilkumar
  • Patent number: 8894986
    Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: November 25, 2014
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr.
  • Publication number: 20140341838
    Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 20, 2014
    Inventors: Natalie Artzi, Elazer R. Edelman, Nuria Oliva Jorge, Maria Carcole Solanes
  • Publication number: 20140341836
    Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
    Type: Application
    Filed: July 9, 2014
    Publication date: November 20, 2014
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
  • Publication number: 20140341837
    Abstract: A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 20, 2014
    Inventors: Talmadge Kelley Keene, John Hen
  • Patent number: 8889114
    Abstract: The present invention refers to the use of growth factors, which are effective on mesothelial cell proliferation, used in a sterilized carboxymethylchitosan pharmaceutical composition employed to reduce postoperative adhesions severity. The present invention also provides a method to inhibit postoperative adhesions severity.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: November 18, 2014
    Assignees: Fundacao Sao Francisco Xavier
    Inventors: Jackson Brandão Lopes, Luis Alberto Oliveira Dallan
  • Publication number: 20140328776
    Abstract: Compositions, kits and methods of preparing a biocompatible film for cosmetic or medical uses are disclosed. The compositions or kits contain polyvinyl acetal (PVA), siloxane and a solvent. The siloxane can have a hydrophilic group. Once the solvent content is reduced, for instance, by evaporation, the mixture of PVA and siloxane is solidified, forming a film. The compositions and kits, optionally, further include one or more of an antimicrobial agent, a pigment, an anti-inflammatory agent, an anesthetic agent or a hemostatic agent. Such a film can be used, for example, in the form of an antimicrobial sealant, a liquid bandage, body paints, scar camouflage, water-proof sun block, makeup sealer, or antimicrobial wipe or spray.
    Type: Application
    Filed: July 16, 2014
    Publication date: November 6, 2014
    Inventor: SHAOSHENG DONG
  • Patent number: 8877169
    Abstract: A method of preparing hydrogel structure, wherein the hydrogel structure comprises: (a) a one way penetrating polyurethane film layer, (b) a hydrophobic pressure sensitive adhesive layer, (c) a multi-directional elastic meltblown nonwoven, (d) an interpenetrating polymer network, and (e) a hydrophilic hydrogel; and the method comprises: (i) coating the hydrogel in a form of solution on the meltblown non-woven to form a product 1, (ii) UV curing the product 1 in step (i), forming a composite comprising a hydrogel layer on the top, an interpenetrating polymer network in the middle, and a meltblown non-woven layer on the bottom, wherein the interpenetrating polymer network is a mixture of the hydrogel and the meltblown non-woven, (iii) providing polyurethane film layer coated with pressure sensitive adhesive layer, and (iv) laminating part of exposed fibers of meltblown non-woven with the pressure sensitive adhesive layer, forming a hydrogel structure.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: November 4, 2014
    Assignee: Compose Element Limited
    Inventor: Tsu-Tai Lin
  • Patent number: 8865655
    Abstract: A compound of the general Structure (VII) or (VIII) including isoteres and pharmaceutically acceptable salts thereof, wherein R1, R2 (where X=—CONR6—), R3 and R7 are the same or different and each represents an amino-acid side chain moiety; R2 (where X=—CHZ—), R4 and R6 are the same or different and each represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; K represents a linear or branched chain of carbon atoms and containing 1-10 atoms; L represents a moiety capable of chelating zinc in the active site of a histone deacetylase (HDAC) or of conversion to such a moiety in vivo (by hydrolysis or reduction, for example); M is a linear or branched chain of carbon or other atoms and containing 1-10 atoms, and capable of undergoing in vivo cleavage to give Structure (VII); and Z is a heteroatom bonded to the macrocycle by a single or double bond, and any other group bonded to Z is H or a protecting group.
    Type: Grant
    Filed: November 22, 2007
    Date of Patent: October 21, 2014
    Assignee: Karus Therapeutics Limited
    Inventors: Arasu Ganesan, Graham Keith Packham, Alexander Richard Liam Cecil
  • Publication number: 20140308331
    Abstract: This invention relates to compositions and applications for an interpolymer network delivery system containing iodine.
    Type: Application
    Filed: August 12, 2012
    Publication date: October 16, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Carmine P. Iovine, Niraj Ramachandran
  • Patent number: 8859618
    Abstract: This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: October 14, 2014
    Assignee: Valeant Pharmaceuticals International
    Inventors: Irwin Palefsky, Ni'Kita Wilson
  • Patent number: 8840873
    Abstract: A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: September 23, 2014
    Assignee: Oculus Innovative Sciences, Inc.
    Inventor: Hojabr Alimi
  • Publication number: 20140271528
    Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Medicus Biosciences LLC
    Inventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
  • Publication number: 20140271491
    Abstract: The present invention relates to a long-lasting medical product for protecting or treating a lesion in the gastrointestinal tract. The medical product includes a protective covering, wherein the medical product upon application at and about the site of the lesion adheres to the gastrointestinal tissue and is capable of remaining at and about the site of the lesion for a time sufficient to allow the lesion to heal or be treated.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: Shaun D. Gittard, John Crowder Sigmon, JR., Vihar C. Surti
  • Publication number: 20140248231
    Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.
    Type: Application
    Filed: May 8, 2014
    Publication date: September 4, 2014
    Applicant: Medicus Biosciences LLC
    Inventors: Syed H. ASKARI, Yeon S. CHOI
  • Patent number: 8821848
    Abstract: A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 2, 2014
    Assignee: Biolife, L.L.C.
    Inventors: Talmadge Kelly Keene, John Hen
  • Publication number: 20140242023
    Abstract: The present invention relates generally to topical compositions and methods of using the same.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicant: Novan, Inc.
    Inventors: Ryan Doxey, Adam Sabouni, Eleftherios Kougoulos, Nathan Stasko
  • Patent number: 8802073
    Abstract: Glycerophosphate salts have been found to hasten the healing of wounds and minimize the formation of scars, particularly when it is first applied to a wound about 0 to about 7 days after the wound is inflicted. Methods and compositions are provided for treating wounds using a composition comprising an effective amount of glycerophosphate salt. In particular, methods are provided for treating wounds using calcium glycerophosphate (CGP), for accelerating the healing process, reducing pain and scar formation, and for the cosmetic reducing, excision, erasure and/or complete repair of scars (scar revision).
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: August 12, 2014
    Assignee: Prelief Inc.
    Inventor: Alan E. Kligerman
  • Patent number: 8784790
    Abstract: Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: July 22, 2014
    Assignee: Medtronic Xomed, Inc.
    Inventors: Matthew F. Myntti, Dana A. Oliver, James B. Hissong, Jennifer G. Medina
  • Publication number: 20140186415
    Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 3, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Ting-Yu SHIH, Tse-Min TENG, Chia-Chun WANG, Yu-Hua CHEN, Jui-Hsiang CHEN, Mei-Ju YANG, Shu-Fang CHIANG, Yen-Chun CHEN, Chia-Ni CHANG
  • Publication number: 20140186289
    Abstract: A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m2/day.
    Type: Application
    Filed: November 22, 2013
    Publication date: July 3, 2014
    Applicant: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr., Max Azevedo
  • Patent number: 8759300
    Abstract: Described herein are fragments of fibronectin and vitronectin and variants thereof that have certain activities, including growth factor-binding activity. Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to fibronectin. Compositions containing such fragments are useful in cosmetic treatments (e.g., the treatment of wrinkles or UV photodamage of skin), and the treatment of wounds and cancer.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: June 24, 2014
    Assignee: The Research Foundation for the State University of New York
    Inventor: Richard A. Clark