Anti-infective Patents (Class 424/78.07)
  • Patent number: 6261577
    Abstract: Non-staining topical iodine disinfecting compositions having the ability to inactivate pathogens associated with skin infections or diseases. based upon the presence of molecular iodine in a concentration above at least 15 ppm. Any other iodine species selected from the group consisting of complexed iodine and triiodide may be present with the total of such other iodine species limited to a concentration of less than about 700 ppm so that any visible stain resulting from the application of this composition on the skin will dissipate without leaving any visible skin coloration.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: July 17, 2001
    Assignee: Symbollon Corporation
    Inventor: Jack Kessler
  • Patent number: 6254881
    Abstract: An antiinfective-free formulation for prophylactic treatment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminium stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: July 3, 2001
    Assignee: Bimeda Research & Development Limited
    Inventors: Vincent McNally, James Patrick Morgan
  • Patent number: 6251145
    Abstract: The present invention relates, firstly, to a cosmetic and/or dermatological composition intended for treating keratin fibers, in particular human keratin fibers and more particularly human hair, comprising, in a support which is suitable for keratin fibers: (a) at least one enzyme of 2-electron oxidoreductase type in the presence of at least one donor for the said enzyme; (b) at least one substantive polymer chosen from the group consisting of: (i) cationic cellulose derivatives; (ii) dimethyldiallylammonium halide homopolymers and copolymers of dimethyldiallylammonium halide and of (meth)acrylic acid; (iii) methacryloyloxyethyltrimethylammonium halide homopolymers and copolymers; (iv) polyquaternary ammonium polymers; (v) vinylpyrrolidone polymers containing cationic units; (vi) mixtures thereof. The present invention also relates to processes for treating keratin fibers, in particular processes for dyeing, permanently reshaping or bleaching the hair using this composition.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: June 26, 2001
    Assignee: L'Oreal S.A.
    Inventors: Roland De La Mettrie, Jean Cotteret, Arnaud De Labrey, Mireille Maubru
  • Patent number: 6251413
    Abstract: A cosmetic or dermatological composition comprising, in an aqueous phase: i) a water-soluble or water-dispersible terephthalic copolyester oligomer comprising dicarboxylate repeat units of formula (I): [—CO—A—CO—O—(CH2—CH2O)n—]  (I) wherein A is 1,4-phenylene and sulfo-1,3-phenylene groups, n ranges from 1 to 4, at least 35 mol % of said units of formula (I) are units of formula (I), wherein A is a 1,4-phenylene group and n is equal to 1, at least 7 mol % of said units of formula (I) are units of formula (I), wherein A is a sulfo-1,3-phenylene group, and the weight-average molecular mass of said copolyester oligomer is less than 20,000, and ii) at least one silicone compound as an emulsion in the aqueous phase, and the composition is intended for making up keratinous substances.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: June 26, 2001
    Assignee: L'Oreal
    Inventors: Véronique Ferrari, Valérie de la Poterie
  • Patent number: 6242509
    Abstract: An ester-terminated dimer acid-based polyamide may be blended with a solvent to form a gel. The solvent may be flammable, and a wick may be added to the resulting gel so as to form a candle. Depending on the composition, the candle may be formed into a free standing pillar, or may be better suited to being placed in a container. The solvent may be mineral oil. A solid coating may be placed around the candle, for advantages including to enhance the clarity and/or mechanical stability of the gelled body, and to eliminate the tendency of a gel to have an oily feel and to accept noticeable fingerprints. The ester-terminated dimer acid-based polyamide may also be combined with an active ingredient, such as a fragrance, colorant, insect-repellant, insecticide, bioactive ingredient or the like, to afford a delivery vehicle for the active ingredient.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: June 5, 2001
    Assignees: International Paper Company, Bush Boake Allen Inc.
    Inventors: Vivian Berger, Jochen Heydel, Virgil A. G. Williams, Charles R. Frihart, Ronald L. Gordon, Richard C. MacQueen, Mark S. Pavlin
  • Patent number: 6228128
    Abstract: A method for antimicrobial treatment of microorganisms and/or viruses which involves treating the microorganisms and/or viruses with an effective amount of a fungal laccase and one or more enhancers in the presence of oxygen, the enhancers having the formula: wherein A, B and C are as defined in the specification.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: May 8, 2001
    Inventors: Charlotte Johansen, Anders Hjelholt Pedersen, Claus Crone Fuglsa{dot over (n)}g
  • Patent number: 6228354
    Abstract: A water-resistant, film-forming topical antimicrobial composition, removable by high pH solution, made in accordance with the principles of the present invention includes a polyvinyl lactam, a broad spectrum antimicrobial agent, a copolymer of polyacrylate/polyoctylacrylamide, a pH sensitive acrylic polymer, and an alcohol. Preferably, the polyvinyl lactam is polyvinyl pyrrolidone. The preferred broad spectrum antimicrobial agent is iodine which is preferably complexed to the polyvinyl pyrrolidone. A process for making the film-forming topical antimicrobial composition is also provided.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: May 8, 2001
    Assignee: Allegiance Corporation
    Inventor: David K. Jeng
  • Patent number: 6214318
    Abstract: Aerosol compositions are provided that enhance the therapeutic action of ointments by producing, upon topical application thereof, a sustained cooling effect that provides fast relief form pain and itching as well as a tendency to shrink swollen, inflamed tissue. The compositions contain oils, thickening agents for the oils, and propellant. Aqueous solutions, therapeutic ingredients and various adjuvants may also be present. The specific propellant and the proportion used are selected to provide a deposit with a temperature of about −5° C. to about +5° C. In this temperature range, the deposit is cold enough for the required therapeutic effect, but not so cold as to cause pain or tissue damage. The choice and proportion of thickening agents used are selected to provide a deposit that does not flow or spread. Were the deposit to spread, it would present a large surface area from which propellant present in the deposit would evaporate rapidly.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: April 10, 2001
    Assignee: OMS Holdings LLC
    Inventors: Lloyd I. Osipow, Dorothea C. Marra, J. George Spitzer
  • Patent number: 6203812
    Abstract: The invention discloses a mammalian teat dip for controlling mastitis, a method for preparing the composition and a method of treatment of mammals. The composition contains a film-forming polymer blend and at least one antimicrobial. The polymer blend contains a solvent-soluble, thermoplastic polyurethane and a hydrophilic poly(N-vinyl lactam). Upon application to mammalian skin, this composition leaves a long-lasting, water-resistant, residual, elastic film which treats and protects mammalian skin from infection.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: March 20, 2001
    Assignee: Hydromer, Inc.
    Inventors: Joseph Ehrhard, Michael Eknoian
  • Patent number: 6200557
    Abstract: A solution or gel composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for destroying HIV. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms. Using a lubricant as a vehicle for the chlorine dioxide/phosphate composition; development of vaginal itching due to Candida Albicans will be stopped.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: March 13, 2001
    Inventor: Perry A. Ratcliff
  • Patent number: 6197325
    Abstract: This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 6, 2001
    Assignee: The American National Red Cross
    Inventors: Martin James MacPhee, William Nash Drohan, Carlos I. Lasa, Jr., Gene Liau, Christian Haudenschild
  • Patent number: 6192887
    Abstract: Microbicidal and spermicidal methods and topical pharmaceutical compositions containing sodium dodecyl sulfate or its derivatives as active ingredients for the prevention and control of pregnancy and sexually transmitted diseases, including human papilloma viruses. Spermicidal barriers and microbial disinfectants containing the compositions are also provided.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: February 27, 2001
    Assignee: The Pennsylvania State University
    Inventors: Mary K. Howett, John W. Kreider
  • Patent number: 6187290
    Abstract: There is described a foamable formulation comprising a foamable carrier and an active ingredient which may be admixed with the carrier or packaged separately and dispersed into the carrier during the foaming process. Alginate gel is a preferred foamable carrier. The foam produced from such a formulation, and a foam sheet produced by drying the foam, also form part of the invention. The formulation, foam and foam sheet are especially useful for medical applications, for example in treating burns. As apparatus to store the components of the formulation and to generate the foam is also described.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: February 13, 2001
    Assignee: Giltech Limited
    Inventors: Thomas Gilchrist, Eilidh Gilchrist