Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) Patents (Class 424/78.08)
  • Patent number: 10426747
    Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth, including killing bacterial biofilms.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 1, 2019
    Inventor: Lanny Leo Johnson
  • Patent number: 10376548
    Abstract: Compositions and methods are provided for improving the health of an animal by reducing certain diseases and by binding certain heavy metals that may be unintentionally introduced into the body of the animal from the environment. Compositions and methods are also provided for improving the feed conversion ratio of an animal. In addition, compositions and methods are provided for reducing nitrate pollution in the environment. In one embodiment, the composition may include mastic gum, a mixture of ionic minerals, and optionally an essential amino acid not produced by the animal. The ionic minerals may be derived from water sourced from an inland sea such as the Great Salt Lake, the Dead Sea, or another inland sea. The essential amino acid may be included in the form of a protein. The animal may be a ruminant, poultry, or other animal. Methods are also provided for processing mastic gum.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 13, 2019
    Assignee: ABSORBEZZ, LLC
    Inventors: Joseph Scivoletto, Steven Adelstein
  • Patent number: 10335493
    Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: July 2, 2019
    Assignee: Emory University
    Inventors: Lily Yang, Xiangxue Gao
  • Patent number: 10336796
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 2, 2019
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Roger P. Simon, Zhigang Xiong
  • Patent number: 10293014
    Abstract: Disclosed is a composition which comprises a combination of Aronia extract in an amount of at least about 10 ?g/mg and seleniumin in an amount from about 0.0001 ?g/mg to about 2.0 ?g/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: May 21, 2019
    Assignee: Ursapharm Arzneimittel GmbH
    Inventors: Klaus Eschmann, Josef Beuth
  • Patent number: 10251923
    Abstract: The invention relates to therapeutic uses of gum mastic, and compounds found therein including polymeric myrcene. More particularly, the invention relates to methods of treating impaired neurological function using compositions comprising polymeric myrcene.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: April 9, 2019
    Assignee: REGENERA PHARMA LTD.
    Inventor: Zadik Hazan
  • Patent number: 9943622
    Abstract: Method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising (a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A B with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens. The lens care solution comprises 0.5 ppm to 10 ppm ?-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl) ammonium chloride; citrate, citric acid or a mixture thereof; and 0.005 wt. % to 0.05 wt. % hyaluronic acid. The method also includes (b) inserting the soaked contact lens into one's eye, and (c) repeating steps (a) and (b).
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: April 17, 2018
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, Joseph A. Chinn, George L. Grobe, III, E. Peter Maziarz
  • Patent number: 9925266
    Abstract: The invention related to a gelling formulation including calcium gluconate in solution in water and a poloaxmer and to the use thereof in the treatment of hydrofluoric acid burns.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: March 27, 2018
    Assignee: Assistance Publique—Hopitaux de Paris
    Inventors: Vincent Boudy, Sandrine Graff De Faget, Marie-Caroline Husson, Imane Boucenna, Laurent Royon, Pierre Colinart
  • Patent number: 9913913
    Abstract: A method for preparing a polymeric reagent is provided, which method includes the optional step of forming an N-hydroxysuccinimdyl ester derivative. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 13, 2018
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 9803047
    Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: October 31, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Nicole S. Sampson, Li Tan, Kathlyn Parker
  • Patent number: 9655367
    Abstract: A composition having a short disinfecting contact time is disclosed. The composition contains a biguanide or guanide, a quaternary ammonium compound and a basic compound in a specific weight ratio to one another. Compositions having less than a two minute disinfection time are disclosed.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: May 23, 2017
    Assignee: LONZA, INC.
    Inventors: Andrew Colurciello, David Koehl
  • Patent number: 9642938
    Abstract: In order to provide (i) a medical composition that has a strong angiogenic effect, has low invasiveness to a body of a patient, and is easy to administer to a living subject and (ii) a medical kit using a medical composition, the medical composition includes: a carrier in a particle form, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support; and cells provided on a surface of the carrier.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: May 9, 2017
    Assignees: OSAKA CITY UNIVERSITY, JAPAN HEALTH SCIENCES FOUNDATION
    Inventors: Shinya Fukumoto, Hidenori Koyama, Yoshiki Nishizawa, Tsutomu Furuzono, Masahiro Okada
  • Patent number: 9642695
    Abstract: In order to provide an artificial blood vessel that can prevent formation of a thrombus and a method for producing the artificial blood vessel, an artificial blood vessel is used (i) in which a peptide including a specific amino acid sequence has been added to an extracellular matrix obtained from a bio-derived vascular tissue and (ii) whose lumen has a cross sectional diameter of 4 mm or less.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: May 9, 2017
    Assignee: JMS CO., LTD.
    Inventors: Tetsuji Yamaoka, Atsushi Mahara
  • Patent number: 9624338
    Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: April 18, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Nicole S. Sampson, Li Tan, Kathlyn Parker
  • Patent number: 9611378
    Abstract: An adhesive composition is provided which exhibits an excellent adhesion rate on metals and low-polarity thermoplastic elastomers, and is excellent in appearance with no clouding of hardened bodies and is good in storage stability. It is a 2-cyanoacrylate-based adhesive composition which includes (a) a 2-cyanoacrylic acid ester and (b) an onium salt represented by the general formula: C+A?(1) where, in formula (1), C+ represents an onium cation, and A? represents a bis(fluorosulfonyl)imide anion.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: April 4, 2017
    Assignee: TOAGOSEI CO., LTD.
    Inventors: Kenichi Ishizaki, Yushi Ando
  • Patent number: 9598503
    Abstract: Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., ?-cyclodextrin, ?-cyclodextrin, and ?-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: March 21, 2017
    Assignee: CERULEAN PHARMA INC.
    Inventors: J. Michael Ramstack, Thomas C. Crawford
  • Patent number: 9492409
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of local pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of moderate to severe pain, neuropathic pain, post herpetic neuralgia and rheumatic pains.
    Type: Grant
    Filed: May 18, 2013
    Date of Patent: November 15, 2016
    Assignee: CELLIX BIO PRIVATE LIMITED
    Inventor: Mahesh Kandula
  • Patent number: 9427469
    Abstract: The present disclosure relates to an activated polymer composition for use in repairing tissue of a patient comprising platelet-rich plasma (PRP), a chitosan solution, a salt such as NaCI or glycerol phosphate, and an activator such as at least one of CaCI2 and a mixture of thrombin/CaCI2.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: August 30, 2016
    Assignee: ORTHO REGENERATIVE TECHNOLOGIES INC.
    Inventors: Wei Ouyang, Michael Buschmann, Anik Chevrier
  • Patent number: 9399070
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 26, 2016
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 9381251
    Abstract: This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: July 5, 2016
    Assignees: INSTITUT QUIMIC DE SARRIA CETS, FUNDACIO PRIVADA, UNIVERSITAT RAMON LLULL, FUNDACIO PRIVADA
    Inventors: Salvador Borros Gomez, David Horna Tomas
  • Patent number: 9380785
    Abstract: To provide an antiviral resin member which can efficiently inactivate viruses and has excellent sustainability. An antiviral resin member comprising a resin, an antiviral agent, and a surface potential-controlling agent, characterized in that the surface potential-controlling agent causes the surface potential of the antiviral resin member to shift to a value on the positive side of the potential of the resin alone.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: July 5, 2016
    Assignee: NBC MESHTEC, INC.
    Inventors: Shinji Kurahashi, Nobukazu Motojima, Yoko Fukui, Tsuruo Nakayama
  • Patent number: 9364509
    Abstract: The invention relates to therapeutic uses of gum mastic, and compounds found therein including polymeric myrcene. More particularly, the invention relates to methods of treating impaired neurological function using compositions comprising polymeric myrcene.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: June 14, 2016
    Assignee: REGENERA PHARMA LTD.
    Inventor: Zadik Hazan
  • Patent number: 9339590
    Abstract: This invention relates to a biomaterial comprising an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. This invention also relates to a medical device including said biomaterial and to a method of repair or treatment including the filling of cavities in the human face or body.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: May 17, 2016
    Assignee: Cutanea Life Sciences, Inc.
    Inventors: Elisabeth Laugier, Frank Gouchet, Bernard Grandmontagne
  • Patent number: 9283247
    Abstract: Dendrimers comprising N-acyl urea terminal moieties are described herein. The dendrimers can be used, for example, in the treatment of arthritis.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: March 15, 2016
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Robert J. Miller, Lauren Elizabeth Young, Rajesh Vasant Kamath
  • Patent number: 9259515
    Abstract: Medical devices, such as stents, fabricated from a polymer including degradable polymer segments joined by di-urethane linkages with radiopaque functional groups chemically bonded to the polymer are disclosed.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: February 16, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Yunbing Wang
  • Patent number: 9180321
    Abstract: A cosmetic composition containing: (a) at least one tackifier component having a solubility parameter corresponding to ?; (b) at least one liposoluble polymer having at least one segment with a solubility parameter corresponding to ?+2; (c) at least one solvent; and (d) optionally, at least one colorant.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: November 10, 2015
    Assignee: L'OREAL S.A.
    Inventors: Hy Si Bui, Shao Xiang Lu, Balanda Atis, Wei Hong Yu
  • Patent number: 9155760
    Abstract: Methods of treatment or prophylaxis of bacterial vaginosis, prevention of recurrence of bacterial vaginosis and alleviation or prevention of symptoms or diagnostic criteria of bacterial vaginosis are provided. The methods include administration of an effective amount of a macromolecule comprising a polylysine, polyamidoamine, poly(etherhydroxyamine) or poly(propyleneimine) dendrimer and one or more sulfonic acid containing moieties attached thereto.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: October 13, 2015
    Assignee: STARPHARMA PTY LIMITED
    Inventors: Jeremy Robert Arthur Paull, Jacinth Kincaid Fairley, Clare Frances Price, Gareth Rhys Lewis
  • Patent number: 9150609
    Abstract: A process for the synthesis of copolymer-1 composed of L-alanine, L-lysine, L-glutamic acid and L-tyrosine for the treatment of multiple sclerosis. The molecular weight of copolymer-1 is between 8-19 KDa. The process is initiated by supported dialkyl amine. The copolymer-1 of the invention has acid content of less than 1%.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: October 6, 2015
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventor: Baijayantimala Garnaik
  • Patent number: 9132106
    Abstract: Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 15, 2015
    Assignee: ABBOTT MEDICAL OPTICS INC.
    Inventors: Stanley W. Huth, Denise Tran
  • Patent number: 9078950
    Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 14, 2015
    Assignee: MicroVention, Inc.
    Inventors: Gregory M. Cruise, Michael J. Constant, Edward Michael Keeley, Rob Greene, Clayton Harris
  • Patent number: 9082984
    Abstract: The present invention relates to a method for dispersing carbon nanotubes. The method may include contacting the carbon nanotubes with a solution containing chondroitin sulfate cation salt of formula (I) wherein R1 is MSO3 and R2 is H, or R1 is H and R2 is MSO3; M is an alkaline metal, or an alkaline earth metal further bound to a monovalent counter-anion; n is at least 20.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: July 14, 2015
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bee Eng Mary Chan, Liangyu Yan
  • Patent number: 9060514
    Abstract: The present invention provides the efficacy-enhancing agent composition for agricultural chemicals containing (A) the sorbitan fatty acid ester surfactant, (B) the rosin-oxyalkylene adduct surfactant or a specified quaternary ammonium salt surfactant, and (C) a specified glycol ether solvent.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: June 23, 2015
    Assignee: KAO CORPORATION
    Inventors: Katsuhiko Yamaguchi, Kazuhiko Kurita
  • Patent number: 9044516
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 2, 2015
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 9034309
    Abstract: Pharmaceutical compositions containing biocidal co-polymers of poly(styrenes), poly(acrylates), poly(acrylamides), and poly(C1-C6)alkylene glycols are disclosed, along with methods of using the compositions to treat microbial infections in mammals.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: May 19, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Samuel H. Gellman, Michael A. Gelman, Bernard Weisblum, David M. Lynn
  • Publication number: 20150125502
    Abstract: A composition having a short disinfecting contact time is disclosed. The composition contains a biguanide or guanide, a quaternary ammonium compound and a basic compound in a specific weight ratio to one another. Compositions having less than a two minute disinfection time are disclosed.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 7, 2015
    Inventors: Andrew COLURCIELLO, David KOEHL
  • Patent number: 9017644
    Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
  • Patent number: 8999377
    Abstract: Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-?(1?4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: April 7, 2015
    Assignee: Surmodics, Inc.
    Inventors: Emily R. Rolfes, Pamela J. Reed
  • Patent number: 8992902
    Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: March 31, 2015
    Assignee: Nektar Therapeutics
    Inventor: Xiaoming Shen
  • Patent number: 8986677
    Abstract: This invention relates to the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the prevention of addiction induced anxiety and withdrawal side effects as a therapeutic and in concert with a diagnostic. Such addictions could be, but are not limited to, alcohol, drugs, caffeine, sugar, food, nicotine, etc.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 24, 2015
    Assignee: Pop Test Cortisol LLC
    Inventors: Randice Lisa Altschul, Neil David Theise, Myron Rapkin, Rebecca O'Brien
  • Patent number: 8974804
    Abstract: Composition for topical application in the form of an oil-in-water emulsion containing an oily phase dispersed in an aqueous phase, and a hydrophilic polymer, the composition further containing (1) at least one elastomeric organopolysiloxane and (2) at least one lipophilic compound chosen from lipophilic amino acid compounds and lipophilic salicylic acid compounds. Uses thereof, including topical application to the skin, lips, hair, etc. Stabilization of certain emulsions using a lipophilic compound.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 10, 2015
    Assignee: L'Oreal
    Inventors: Christine Noel, Anne-France Livernette
  • Patent number: 8974769
    Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Hao-Li Liu
  • Patent number: 8962818
    Abstract: Compositions and kits comprising a nucleotide sequence that encodes GHRH and a nucleotide sequence that encodes GnRH and compositions and kits comprising a GHRH protein and GnRH protein are disclosed. Use of such compositions and kits in methods of enhancing fertility in mammals comprising the step of administering said compositions to the mammal are disclosed.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: February 24, 2015
    Assignee: VGX Pharmaceuticals, Inc.
    Inventors: Ruxandra Draghia-Akli, Amir Khan, Patricia Brown
  • Patent number: 8962566
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 24, 2015
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Patent number: 8956601
    Abstract: The invention relates to pharmaceutical compositions and formulations comprising polymeric myrcene. More particularly, the invention relates to compositions comprising an isolated fraction of polymeric myrcene in a hydrophobic carrier and formulations which maintain the biological activity of the active polymer.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: February 17, 2015
    Assignee: Regenera Pharma Ltd.
    Inventor: Zadik Hazan
  • Patent number: 8945526
    Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: February 3, 2015
    Assignees: Shimadzu Corporation, Kyoto University
    Inventors: Hitoshi Akitsu, Eiichi Ozeki, Ryoji Fushimi, Shunsaku Kimura, Masashi Isozaki, Shigenori Nozawa
  • Patent number: 8945527
    Abstract: The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C?O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: February 3, 2015
    Assignees: The University of North Carolina at Chapel Hill, Liquidia Technologies, Inc.
    Inventors: Joseph DeSimone, Matthew Parrott, Andrew Murphy, Robby A. Petros
  • Publication number: 20150010471
    Abstract: One aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compositions gel at or below body temperature. In certain embodiments of the methods of embolization, said composition further comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Inventors: Alexander Schwarz, Jean Raymond
  • Patent number: 8921448
    Abstract: A low toxicity, highly efficient transfection composition is described with an amphipathic compound containing at least one imidazole. The composition may be used in the process of transfecting nucleic acids into an animal cell.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: December 30, 2014
    Assignee: Mirus Bio LLC
    Inventors: Shannon E. Bruse, Laura K Juckem, Karen M Neder
  • Patent number: 8916142
    Abstract: The invention relates to a supramolecular polymer obtained from the reaction of (i) an amine bearing a nitrogen-containing heterocyclic group: imidazolidone, trimethyleneurea or triazine, which is capable of associating by means of hydrogen bonds and (ii) at least one fatty acid monomer comprising at least one reactive function, a dimer of identical or different fatty acids and/or a trimer of identical or different fatty acids, or a derivative of said fatty acid(s) which is selected from a fatty acid ester, and a fatty acid chloride.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: December 23, 2014
    Assignees: Arkema France, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Sandra Grimaldi, Jean-Philippe Gillet, Manuel Hidalgo, Francois-Genes Tournilhac, Philippe Cordier, Ludwik Leibler
  • Patent number: 8911720
    Abstract: The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using a citric acid copolymers.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: December 16, 2014
    Assignee: Northwestern University
    Inventors: Guillermo Ameer, Jian Yang, Antonio Roy Webb