Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Abstract: This invention relates to the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the prevention of addiction induced anxiety and withdrawal side effects as a therapeutic and in concert with a diagnostic. Such addictions could be, but are not limited to, alcohol, drugs, caffeine, sugar, food, nicotine, etc.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
March 24, 2015
Assignee:
Pop Test Cortisol LLC
Inventors:
Randice Lisa Altschul, Neil David Theise, Myron Rapkin, Rebecca O'Brien
Abstract: Composition for topical application in the form of an oil-in-water emulsion containing an oily phase dispersed in an aqueous phase, and a hydrophilic polymer, the composition further containing (1) at least one elastomeric organopolysiloxane and (2) at least one lipophilic compound chosen from lipophilic amino acid compounds and lipophilic salicylic acid compounds. Uses thereof, including topical application to the skin, lips, hair, etc. Stabilization of certain emulsions using a lipophilic compound.
Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
February 24, 2015
Assignee:
Nektar Therapeutics
Inventors:
Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
Abstract: Compositions and kits comprising a nucleotide sequence that encodes GHRH and a nucleotide sequence that encodes GnRH and compositions and kits comprising a GHRH protein and GnRH protein are disclosed. Use of such compositions and kits in methods of enhancing fertility in mammals comprising the step of administering said compositions to the mammal are disclosed.
Type:
Grant
Filed:
March 6, 2009
Date of Patent:
February 24, 2015
Assignee:
VGX Pharmaceuticals, Inc.
Inventors:
Ruxandra Draghia-Akli, Amir Khan, Patricia Brown
Abstract: The invention relates to pharmaceutical compositions and formulations comprising polymeric myrcene. More particularly, the invention relates to compositions comprising an isolated fraction of polymeric myrcene in a hydrophobic carrier and formulations which maintain the biological activity of the active polymer.
Abstract: The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C?O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.
Type:
Grant
Filed:
April 24, 2009
Date of Patent:
February 3, 2015
Assignees:
The University of North Carolina at Chapel Hill, Liquidia Technologies, Inc.
Inventors:
Joseph DeSimone, Matthew Parrott, Andrew Murphy, Robby A. Petros
Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.
Abstract: One aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compositions gel at or below body temperature. In certain embodiments of the methods of embolization, said composition further comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound.
Abstract: A low toxicity, highly efficient transfection composition is described with an amphipathic compound containing at least one imidazole. The composition may be used in the process of transfecting nucleic acids into an animal cell.
Type:
Grant
Filed:
July 16, 2010
Date of Patent:
December 30, 2014
Assignee:
Mirus Bio LLC
Inventors:
Shannon E. Bruse, Laura K Juckem, Karen M Neder
Abstract: The invention relates to a supramolecular polymer obtained from the reaction of (i) an amine bearing a nitrogen-containing heterocyclic group: imidazolidone, trimethyleneurea or triazine, which is capable of associating by means of hydrogen bonds and (ii) at least one fatty acid monomer comprising at least one reactive function, a dimer of identical or different fatty acids and/or a trimer of identical or different fatty acids, or a derivative of said fatty acid(s) which is selected from a fatty acid ester, and a fatty acid chloride.
Type:
Grant
Filed:
September 7, 2007
Date of Patent:
December 23, 2014
Assignees:
Arkema France, Centre National de la Recherche Scientifique (CNRS)
Inventors:
Sandra Grimaldi, Jean-Philippe Gillet, Manuel Hidalgo, Francois-Genes Tournilhac, Philippe Cordier, Ludwik Leibler
Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
Type:
Grant
Filed:
December 30, 2009
Date of Patent:
December 16, 2014
Assignees:
Boston Scientific Scimed, Inc., The University of Massachusetts Lowell
Inventors:
Mark Boden, Marlene C. Schwarz, Frederick H. Strickler, Rudolf Faust, Umaprasana Ojha, Tomoya Higashihara
Abstract: The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using a citric acid copolymers.
Type:
Grant
Filed:
August 28, 2012
Date of Patent:
December 16, 2014
Assignee:
Northwestern University
Inventors:
Guillermo Ameer, Jian Yang, Antonio Roy Webb
Abstract: Provided herein are compounds and methods for achieving a sustained therapeutic effect of small molecule anti-cancer agents when administered in vivo.
Type:
Grant
Filed:
September 23, 2009
Date of Patent:
December 9, 2014
Assignee:
Nektar Therapeutics
Inventors:
Michael A. Eldon, Shibani S. Harite, Tamra L. Barker
Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
Type:
Application
Filed:
February 24, 2011
Publication date:
December 4, 2014
Applicant:
RELYPSA, INC.
Inventors:
Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Grace Huynh, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
Abstract: The present invention provides semi-fluorinated block copolymers and related methods of synthesizing and using semi-fluorinated block copolymers for drug delivery and drug formulation applications. Semi-fluorinated block copolymers of this aspect of the invention include block copolymers having discrete hydrophilic, fluorophilic and hydrophobic structural domains that are capable of forming supramolecular structures in aqueous solutions, such as micelles, for encapsulating hydrophobic and/or fluorophilic therapeutic agents. Encapsulation by semi-fluorinated block copolymers of the present invention allows for enhanced solubilization and stabilization of hydrophobic and/or fluorophilic therapeutic agents relative to conventional drug delivery compositions and methods.
Abstract: A liquid composition containing a polymer micelle and having a pH values of 3.0 to 7.0 is provided. The micelle is constituted of a coordination compound having a block copolymer of polyethylene glycol and polyglutamic acid and cisplatin that is coordinate-bonded to the block copolymer.
Type:
Grant
Filed:
May 27, 2009
Date of Patent:
November 25, 2014
Assignees:
Nanocarrier Co., Ltd., The University of Tokyo
Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
Type:
Grant
Filed:
October 9, 2012
Date of Patent:
November 18, 2014
Assignee:
Relypsa, Inc.
Inventors:
Dominique Charmot, Han-Ting Chang, Gerrit Klaerner, Jerry M. Buysse, Mingjun Liu
Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
Abstract: The present invention provides a composition and method for the covalent binding of a hydrogel to an extracellular matrix (ECM). Therapeutic applications include tissue repair and delivery of drugs or cells.
Type:
Grant
Filed:
October 9, 2004
Date of Patent:
November 11, 2014
Assignee:
Synthasome, Inc.
Inventors:
Anthony Ratcliffe, Jennifer H. Elisseeff, Dongan Wang
Abstract: The invention relates to a cosmetic composition comprising at least one polar modified polymer and at least one tackifier, as well as to methods of using such compositions.
Type:
Grant
Filed:
June 28, 2010
Date of Patent:
November 11, 2014
Assignee:
L'Oreal
Inventors:
Hy Si Bui, Mohamed Kanji, Balanda Atis, Susan Halpern, Florentina Pavel
Abstract: A personal care composition comprising at least one saccharide-siloxane copolymer having a saccharide component and an organosiloxane component and linked by a linking group, wherein the saccharide-siloxane copolymer has a specified formula, is provided. The personal care composition is adapted to provide at least one benefit to the at least one portion of the body to which it is applied. Emulsions, methods for preparing emulsions comprising saccharide-siloxane copolymers, and personal care products comprising the personal care compositions and emulsions are also provided.
Type:
Grant
Filed:
May 23, 2006
Date of Patent:
November 4, 2014
Assignee:
Dow Corning Corporation
Inventors:
Eric Jude Joffre, Bethany K. Johnson, Brian Jeffery Swanton, Michael Stephen Starch
Abstract: Polymeric reagents comprising a polymer attached, either directly or through one or more atoms, to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
Type:
Grant
Filed:
March 6, 2007
Date of Patent:
October 21, 2014
Assignee:
Nektar Therapeutics
Inventors:
Samuel P. McManus, Antoni Kozlowski, Xiaoming Shen, Daniel C. Cook
Abstract: Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles.
Type:
Grant
Filed:
January 9, 2009
Date of Patent:
October 14, 2014
Assignee:
President and Fellows of Harvard College
Abstract: Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
Abstract: One aspect of the present invention relates to a method of occluding a vascular site in a mammal, comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding a vascular site of said mammal, wherein said temporarily occluded vasculature site is kept in a substantially cylindrical shape.
Abstract: The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.
Abstract: Polymeric compounds containing polymer backbones functionalized with ion-specific recognition elements and methods for the use of these compounds are described herein. The polymeric compounds may contain multiple types of ion-specific recognition elements depending on a specific application. The polymeric compounds can be used to remove ionic species from a solution, for example, in separations applications in which a single or multiple types of ionic species are desired to be removed from the solution.
Type:
Grant
Filed:
November 23, 2009
Date of Patent:
August 12, 2014
Assignee:
Board of Regents, The University of Texas System
Inventors:
Jonathan L. Sessler, Christopher W. Bielawski, Abdullah Aydogan, Daniel J. Coady
Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
Type:
Grant
Filed:
April 13, 2012
Date of Patent:
August 12, 2014
Assignee:
Massachusetts Institute of Technology
Inventors:
Natalie Artzi, Elazer R. Edelman, Núria Oliva Jorge, Maria Carcolé Solanes
Abstract: A delivery vehicle including a mixture of: a) an effective amount of an expander activatable by a wetting agent and, b) a treatment agent. The expander and treatment agent intermingled and compressed so as to form a substantially solid delivery vehicle. The solid delivery vehicle, on exposure to a volume of wetting agent forms a predetermined volume of a paste containing the treatment agent; and the volume of paste is adapted for delivery of the treatment agent.
Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least one transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
Type:
Grant
Filed:
April 27, 2010
Date of Patent:
August 5, 2014
Assignee:
Dow AgroSciences, LLC
Inventors:
Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, Jr., James E. Dripps, Margaret S. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers.
Type:
Grant
Filed:
August 20, 2009
Date of Patent:
August 5, 2014
Assignee:
The Research Foundation for The State University of New York
Inventors:
Nicole Sampson, Kathlyn Parker, Airong Song
Abstract: The present application relates to a polycondensate that can be obtained by reaction: of polyol containing 3 to 6 hydroxyl groups; of non-aromatic, saturated or unsaturated monocarboxylic acid; of aromatic monocarboxylic acid containing 7 to 11 carbon atoms; and of polycarboxylic acid, saturated or unsaturated, or even aromatic, linear, branched and/or cyclic, containing at least 2 carboxyl groups COOH; and/or a cyclic anhydride of such a polycarboxylic acid. The application also relates to a method of cosmetic treatment employing said composition, the polycondensate thus defined and a method of preparation of the polycondensate.
Type:
Grant
Filed:
June 21, 2007
Date of Patent:
July 29, 2014
Assignee:
L'Oreal
Inventors:
Gerard Malle, Jean Mondet, Xavier Blin, Ivan Rodriguez, Pascal Giustiniani
Abstract: Tissue adhesives formed by reacting poly(hydroxylic) compounds derivatized with acetoacetate groups and/or polyamino compounds derivatized with acetoacetamide groups with an amino-functional crosslinking compound are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; and anti-adhesive applications are described.
Abstract: Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
Type:
Grant
Filed:
October 3, 2008
Date of Patent:
July 22, 2014
Assignees:
William Marsh Rice University, Board of Regents, The University of Texas System
Inventors:
James M. Tour, Rebecca Lucente-Schultz, Ashley Leonard, Dmitry V. Kosynkin, Brandi Katherine Price, Jared L. Hudson, Jodie L. Conyers, Jr., Valerie C. Moore, S. Ward Casscells, Jeffrey N. Myers, Zvonimir L. Milas, Kathy A. Mason, Luka Milas
Abstract: The present invention is directed to a non-sticky, hydrating and moisturizing aqueous lip gloss having: (a) at least one alkyl ethoxylated polymer wax; (b) at least one oil soluble polar modified polymer; (c) water; (d) at least one non volatile oil capable of solubilizing the polar modified polymer; and (e) optionally, at least one colorant, and wherein the composition does not require silicone fluids therein.
Abstract: A cosmetic composition containing at least one block copolymer having a hard segment and a soft segment, at least one tackifier component, at least one solvent, or solvent mixture, optionally, at least one modified silicone, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of about 50° C. or more, and the at least one soft segment has a Tg value of about 20° C. or less, and wherein the at least one solvent, or solvent mixture, is capable of solubilizing either the at least one hard segment or the at least one soft segment, or both the hard and the soft segments.
Type:
Grant
Filed:
May 3, 2006
Date of Patent:
July 15, 2014
Assignee:
L'Oréal
Inventors:
Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado, Xavier Blin, Pascal Arnaud
Abstract: Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.
Type:
Grant
Filed:
October 17, 2002
Date of Patent:
July 15, 2014
Assignee:
Samyang Biopharmaceuticals Corporation
Inventors:
Min-Hyo Seo, Bong-Oh Kim, In-Ja Choi, Myung-Seob Shim
Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Abstract: A cosmetic composition containing at least one block copolymer having a hard segment and a soft segment, at least one tackifier component, at least one solvent, at least one gelling agent, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more, and the at least one soft segment has a Tg value of 20° C. or less, and the at least one solvent, or solvent mixture, is capable of solubilizing either the at least one hard segment or the at least one soft segment, or both the hard and the soft segments.
Type:
Grant
Filed:
May 3, 2006
Date of Patent:
June 24, 2014
Assignee:
L'Oreal
Inventors:
Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado
Abstract: Provided is a composition for promoting ketone body production that comprises a water insoluble polymer of a ?-hydroxy short-medium chain fatty acid such as homopolymer of ?-hydroxybutyric acid or a copolymer of ?-hydroxybutyric acid and ?-hydroxyvaleric acid. The composition is useful for the treatment or prevention of a disease or condition that can be treated by promoting ketone body production.
Abstract: Polymeric articles capable of releasing drugs at therapeutic levels over extended periods of time, and methods for producing the extended release articles.
Type:
Grant
Filed:
June 2, 2010
Date of Patent:
June 10, 2014
Assignee:
Princeton Trade & Technology, Inc.
Inventors:
Mohamed E. Labib, Theodore Davidson, Stanislav S. Dukhin, James Christopher Post, Garth Ehrlich, Paul Stoodley
Abstract: Disclosed herein is a composition and method of making a polymerizable antibacterial/antimicrobial resin and using such a bioactive resin in formulated dental compositions.
Abstract: The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as chondroitin sulfates, carboxymethyl celluloses, or hyaluronic acids; functional compounds such as peptides, proteins, growth factors; or drugs; or biocompatible polymers such as poly(ethylene oxide), poly(vinyl alcohol), or poly(vinyl pyrrolidone). The present disclosure also provides their synthesis methods, products of hydrogels and films using the same as and methods for manufacturing the products.
Type:
Grant
Filed:
October 29, 2009
Date of Patent:
June 3, 2014
Assignee:
Seoul National University of Technology Center for Industrial Collaboration
Inventors:
Insup Noh, Seongyeun Jo, Doyeon Kim, Junghoon Woo
Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
Type:
Grant
Filed:
November 19, 2012
Date of Patent:
May 13, 2014
Assignee:
Nektar Therapeutics
Inventors:
Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
Abstract: An aqueous composition for treatment of water comprising: (a) an N,N-dimethyl-2-hydroxypropylammonium chloride polymer; (b) lanthanum chloride; and (c) a dimethylamine epichlorohydrin ethylenediamine polymer; and a method of treating water using the composition.
Abstract: Polysiloxane-based materials, which include metal species, are provided. The polysiloxane-based compositions and materials generally include (i) amino-functional polysiloxane material and (ii) a plurality of metal species distributed within the polymeric material. Polymer based compositions in which the amino-functional polysiloxane material includes quaternary ammonium groups, e.g., tetraalkyl ammonium groups, are examples of suitable materials which may be used to form the present compositions. The metal species, which may be in an oxidized and/or neutral state, may be bonded, coordinated, chelated, suspended, and/or dispersed within the polymeric material.
Abstract: Embodiments of the invention include a system comprising: an Acetoxy curable silicone Binder; and an active agent blended with the silicone binder, effective for one or more of radiopacification, lubricity, elution of a secondary compound such as a drug, echogenic properties, thermal or electrically insulative properties or chemical indicators wherein the silicone binder effectiveness is not substantially changed by the active agent.