Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) Patents (Class 424/78.08)
  • Patent number: 8703113
    Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: April 22, 2014
    Assignee: REVA Medical Inc.
    Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
  • Patent number: 8703111
    Abstract: This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: April 22, 2014
    Assignees: Institut Quimic de Sarria Cets, Fundacio Privada, Universitat Ramon Llull, Fundacio Privada
    Inventors: Salvador Borros Gómez, David Horna Tomás
  • Publication number: 20140105828
    Abstract: This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 17, 2014
    Applicant: Emory University
    Inventor: Lily Yang
  • Patent number: 8691580
    Abstract: In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3? and/or 5? end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: April 8, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jeffrey G. Aaronson, Stanley F. Barnett, René Bartz, Steven L. Colletti, Vasant R. Jadhav, Aaron A. Momose, Anthony W. Shaw, David M. Tellers, Thomas J. Tucker, Weimin Wang, Yu Yuan
  • Patent number: 8691245
    Abstract: The present invention relates to a method for forming a temporary obstruction of the intestine of a mammal, using a solidifiable composition, said composition being flowable and solidifiable to form a solid plug at a desired site within the intestine, the structure of said plug being changeable in order to allow for the subsequent, at least partial removal of the obstruction.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: April 8, 2014
    Inventor: Georg Bischof
  • Patent number: 8691204
    Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
  • Publication number: 20140093472
    Abstract: The invention relates to an aqueous ophthalmic solution comprising 0.00001 to about 10.0 percent by weight L-histidine, 0.0001 to 3.0 percent by weight hydrogen peroxide, and optionally 0.1 to 500 parts per million of a preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 3, 2014
    Applicant: FXS Ventures, LLC
    Inventor: Francis X. Smith
  • Patent number: 8679536
    Abstract: Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamax Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Patent number: 8679537
    Abstract: Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: March 25, 2014
    Assignee: Actamaz Surgical Materials, LLC
    Inventor: Samuel David Arthur
  • Patent number: 8680182
    Abstract: The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering to the spinal cord injury site a vehicle comprising a neurotrophic factor and/or anti-inflammatory agent. Also provided are methods of treating a spinal cord injury by topically administering or delivering a hydrogel to the injury site.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: March 25, 2014
    Assignees: Clemson University Research Foundation, MUSC Foundation for Research Development
    Inventors: Xing Jin, Xuejun Wen, Vibhor Krishna, Ning Zhang
  • Patent number: 8673282
    Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, at least one solvent capable of solubilizing the soft segment, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg of about 50° C. or more and the at least one soft segment has a Tg value of about 20° C. or less.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 18, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado
  • Patent number: 8673284
    Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, at least one solvent capable of solubilizing the at least one hard segment, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of about 50° C. or more and the at least one soft segment has a Tg value of about 20° C. or less.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 18, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado
  • Patent number: 8673283
    Abstract: A cosmetic composition containing at least one block copolymer having at least one hard segment and at least one soft segment, at least one tackifier component, a solvent mixture, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more, the at least one soft segment has a Tg value of 20° C. or less, and wherein the solvent mixture contains at least one solvent capable of solubilizing the at least one hard segment, and at least one solvent capable of solubilizing the at least one soft segment.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 18, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado
  • Patent number: 8658141
    Abstract: The present invention is directed to a method of making up keratinous substrates involving applying onto the keratinous substrate a composition containing a) a block copolymer, b) a tackifier, c) an alkyl silsesquioxane wax, d) a liquid fatty phase, and e) optionally, a colorant.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: February 25, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Ann Marie Rohmeyer, Padraig McDermott
  • Patent number: 8658148
    Abstract: Dendrimers comprising N-acyl urea terminal moieties are described herein. The dendrimers can be used, for example, in the treatment of arthritis.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: February 25, 2014
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Robert J. Miller, Lauren Elizabeth Young, Rajesh Vasant Kamath
  • Publication number: 20140044671
    Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Genzyme Corporation
    Inventors: Chad C. Huval, Pradeep Dhal, S. Randall Holmes-Farley
  • Patent number: 8647614
    Abstract: A method for reducing the occurrence of new post-operative fractures in vertebrae of a patient's spine after a vertebroplasty procedure performed to stabilize a fracture in a vertebra of a patient comprising the steps of performing a vertebroplasty procedure to stabilize a fracture in a vertebra of the patient, wherein the vertebroplasty procedure comprises the step of injecting a material into the fractured vertebra, wherein the material is formed by mixing together a first paste and a second paste, wherein the first paste comprises at least one of a polymerizable monomer and a filler, and wherein the second paste comprises at least one of a polymerizable monomer and a filler.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: February 11, 2014
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Maarten Persenaire, Gina M. Nagvajara, Marissa M. Darmoc, Matthew B. Havener, Stephen G. Gilbert, Erik M. Erbe
  • Patent number: 8642022
    Abstract: The present invention provides for a personal care composition suitable for treating hair comprising a composition comprising the reaction product of a) an oxirane or oxetane compound comprising at least two oxirane or oxetane groups; and b) an amino silane having the formula: N(H)(R1)R2Si(OR3)3-a-b-c(OR4)a(R5Si(OR6)d(R7)c)bR8c with R1 is chosen from the group consisting of H or a monovalent hydrocarbon radical containing one to 20 carbon atoms; R2 is selected from a group consisting of a divalent linear or branched hydrocarbon radical consisting of 1-60 carbons; R4 is a hydrocarbon radical that contains 3 to 200 carbon atoms; R5 is selected from a group consisting of oxygen or a divalent linear or branched hydrocarbon radical consisting of 1-60 carbons; R3, R6, R7, and R8 and are each independently selected from the group of monovalent linear or branched hydrocarbon radicals having from 1 to 200 carbon atoms; the subscript b is zero or a positive number and has a value ranging from 0 to 3; the subscripts a i
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: February 4, 2014
    Assignee: Momentive Performance Materials Inc.
    Inventors: Benjamin Falk, Anne Dussaud, Lara P. Fieschi-Corso
  • Patent number: 8637466
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: January 28, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Patent number: 8637063
    Abstract: The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: January 28, 2014
    Assignee: Cambridge Polymer Group, Inc.
    Inventors: Edward T. Kopesky, Jason Berlin, Martin F. Van Buren, Gavin J. C. Braithwaite
  • Patent number: 8628761
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 14, 2014
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 8614190
    Abstract: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A??Formula (I) B-A-B-(BOX-B-A-B)n-BOX-B-A-B??Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2?-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 24, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Shen-Hua Peng, Hsin-Hsin Shen, Liang-Yo Yang, Meng-Yow Hsieh, Pei-Shan Li, Wei-Lin Yu, Tsai-Yu Lin, Po-Liang Lai, Jui-Sheng Sun, Chih-Hung Chang, Yi-Hung Lin
  • Patent number: 8603452
    Abstract: The invention comprises a biological hydrogel that is chemically stabilized with non-covalent or covalent cross-links. The biological hydrogel is used to coat surfaces of materials for submersion in marine water. Molecular dissolution at the marine water-hydrogel surface prevents attachment of fouling organisms. The rate of dissolution can be controlled by both the concentration of the biopolymer in the hydrogel and the nature and concentration of cross-linker used. Additional components, either molecular or particulate, can be added to the biological hydrogel before or after cross-linking for enhanced properties.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: December 10, 2013
    Assignee: University of South Florida
    Inventor: Thomas J. Koob
  • Patent number: 8597630
    Abstract: The invention relates to materials comprising polymer network containing siloxanes or organic-based core structures, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to an organic core functionalized with polymers. In another embodiment, organic core-polymer conjugates comprise polylactone segments. The organic core-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: December 3, 2013
    Assignee: University of Massachusetts
    Inventors: Jie Song, Jianwen Xu
  • Publication number: 20130315854
    Abstract: A composition for use in treating soft tissue in a living creature with a bulking material prepared in situ from a composition of an addition curable polysiloxane system.
    Type: Application
    Filed: May 23, 2013
    Publication date: November 28, 2013
    Inventor: Jan Albert de VRIES
  • Patent number: 8591933
    Abstract: The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: November 26, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Brenda Russell, Tejal A. Desai, Paul Goldspink
  • Patent number: 8586681
    Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: November 19, 2013
    Assignee: Nektar Therapeutics
    Inventor: Xuan Zhao
  • Patent number: 8586705
    Abstract: The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: November 19, 2013
    Assignee: Starpharma Pty Limited
    Inventors: Guy Yeoman Krippner, Gottfried Lichti, Pasquale Razzino, Brian Devlin Kelly, Susanne Pallich, Scott Andrew Henderson, Angela Michelle Scheppokat, Charlotte Claire Williams, Christopher John Hamilton Porter, Benjamin James Boyd, Lisa Michelle Kaminskas, Phillip Martin Rendle, Ben William Greatrex
  • Patent number: 8574558
    Abstract: A photopolymerizable composition for forming a cosmetic coating for natural and artificial nails of humans and animals comprising a photoinitiator and a (meth)acrylate monomer prepared by reacting a core polyol derived or functionalized from a renewable resource with an a (meth)acrylate monomer and coatings formed from such compositions under UV or other radiation.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 5, 2013
    Assignee: Mycone Dental Supply Co., Inc.
    Inventor: Lawrence W. Steffier
  • Patent number: 8574604
    Abstract: The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 5, 2013
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, Paul J. Santerre, Meilin Yang
  • Patent number: 8568705
    Abstract: A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: October 29, 2013
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • Patent number: 8562961
    Abstract: The present invention is directed to a cosmetic composition includes (a) at least one sugar silicone surfactant; (b) at least one polyamine; (c) at least one oil-soluble polar modified polymer; (d) at least one gelling agent; (e) at least one hyperbranched polyol; and (f) water.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: October 22, 2013
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Mohamed Kanji, Susan Halpern
  • Patent number: 8557230
    Abstract: A cosmetic composition containing at least one block copolymer having a hard segment and a soft segment, at least one tackifier component, at least one solvent, or solvent mixture, at least one shine enhancing agent, and optionally, at least one colorant, and wherein the at least one hard segment has a Tg value of 50° C. or more and the at least one soft segment has a Tg value of 20° C. or less, and the at least one solvent, or solvent mixture, is capable of solubilizing either the at least one hard segment or the at least one soft segment, or both the hard and the soft segments.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: October 15, 2013
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Shaoxiang Lu, Francois Pradier, Ramon Mercado, Xavier Blin
  • Patent number: 8552135
    Abstract: Linear polydialkoxysiloxanes with 2-8 polymeric units have been reacted with alcohols by a transetherification reaction to provide hydrophilic and water soluble silicone products. The glycerol substituted siloxanes in particular are effective in topically treating skin lesions such as radiation burns. Compositions including the substituted polydialkoxysiloxane products inhibit biofilm formation when used as coatings on hard surfaces.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 8, 2013
    Assignee: One Unlimited, Inc.
    Inventor: Leonard William Luria
  • Patent number: 8551511
    Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: October 8, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Don K. Brandom, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
  • Patent number: 8541020
    Abstract: The invention aims at providing a polymeric hydrogel which is highly resistant to water washing. The aim is attained by a polymeric hydrogel comprising a polymeric matrix formed by copolymerizing a nonionic polymerizable monomer with a crosslinking monomer, characterized in that the polymeric matrix contains a wetting agent and water, at least 50 wt % of the wetting agent is constituted of a polymer prepared by polymerizing a polyhydric alcohol monomer component containing a trihydric or more alcohol monomer, and the polymer is a water-soluble one which has an average molecular weight of 150 to 4000 and satisfies the relationship: {(number of ether groups in the polymer+number of hydroxyl groups in the polymer)/number of carbon atoms present in the polymer}?1/3.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: September 24, 2013
    Assignee: Seikisui Plastics Co., Ltd.
    Inventors: Shuichi Sasahara, Kazuhiro Yosikawa, Shinichi Wakamatsu, Takahiko Fujita
  • Patent number: 8535799
    Abstract: A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier, which has a melting point of about 5° C. or more which is present in the first composition in liquid form, on a second composition comprising a material in solid form, the second composition having a temperature of at the most a temperature corresponding to the melting point of the carrier and/or the carrier composition and ii) mixing or others means of mechanical working the second composition onto which the first composition is sprayed to obtain the particulate material.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: September 17, 2013
    Assignee: Veloxis Pharmaceuticals A/S
    Inventors: Anders Burr, Michiel Ringkjøbing-Elema, Jannie Egeskov Holm, Per Holm, Birgitte Møllgaard, Kirsten Schultz
  • Patent number: 8530526
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: September 10, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 8529880
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: September 10, 2013
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 8524213
    Abstract: Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 3, 2013
    Assignee: Genzyme Corporation
    Inventors: Adelya K. Leshchiner, Paul Konowicz, Min-Yeh Grace Chang, Valentina Vasilyeva
  • Patent number: 8512760
    Abstract: A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: August 20, 2013
    Assignee: The University Court of the University of Dundee
    Inventors: James Anthony Cairns, Roderick Allan George Gibson, Graham James Berry
  • Patent number: 8506978
    Abstract: A tissue product comprising an additive composition onto at least the surface of a fibrous article in order to increase the surface potential of the article, while retaining or improving manufacturing efficiency is disclosed. The additive composition comprises a bacteriostatic component and more preferably a water-soluble adhesive component and a bacteriostatic component. In some aspects, the additive may also contain additional water-soluble modifier components. Tissue products according to the present disclosure can attract and trap negatively charged matter, such as bacteria, into the tissue web. As such, tissue products can pickup bacteria from a surface and substantially hold the bacteria in the sheet to help prevent spreading bacteria to other surfaces.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: August 13, 2013
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Dave Allen Soerens, Cathleen Mae Uttecht, Bao Trong Do, SooYeon Oh
  • Patent number: 8491881
    Abstract: A biological coating material that includes a polymerizable polyacrylate monomer; a volatile liquid; a polymer selected from a synthetic rubber, a natural rubber, and a thermoplastic elastomer. The biological liquid coating material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: July 23, 2013
    Assignee: Rochal Industries, LLP
    Inventors: Ann Beal Salamone, Joseph C. Salamone
  • Patent number: 8491879
    Abstract: The invention relates to novel compounds, in particular ammonium-polyurethane and/or polycarbonate compounds, in particular ammonium-polyurethane-polydiorganosiloxane and/or polycarbonate-polydiorganosiloxane compounds, methods for their production as well as their use.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: July 23, 2013
    Assignee: Momentive Performance Materials GmbH
    Inventors: Roland Wagner, Karl-Heiz Sockel, Walter Simon
  • Patent number: 8491878
    Abstract: A sanitizing formulation comprising a solution of an acidic polymer and an anionic surfactant in a liquid vehicle. Suitable acidic polymers are those which include adjacent —[—CR1.COOH—]— units where R1 is defined in their structure, for example polymers based on maleic acid moieties which typically include —[—CH.COOH—CH.COOH—]— units, such as known Gantrez™ polymers. A suitable anionic surfact is sodium lauryl sulphate.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: July 23, 2013
    Assignee: Glaxo Group Limited
    Inventors: Simon King, Madhu Parmar, Kimberly Biedermann, Philip Oths
  • Patent number: 8481017
    Abstract: A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition. The medium has a polyelectrolyte film on at least one surface of an article wherein the polyelectrolyte film is characterized by an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer. The predominantly positively charged polymer, the predominantly negatively charged polymer or both contain (i) a pH sensitive imidazole repeat unit having a pKa between 3 and 9, or (ii) a redox sensitive repeat unit selected from the group consisting of quaternized bipyridine repeat units, coordinated metal repeat units, pyrrole repeat units, aniline repeat units, thiophene repeat units and combinations thereof having a redox potential between +1.2 volts and ?1.2 volts versus a standard hydrogen electrode.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: July 9, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Joseph B. Schlenoff, Zhijie Sui, David S. Salloum, Hassan Rmaile
  • Patent number: 8475782
    Abstract: The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: July 2, 2013
    Assignees: Institut Curie, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie (Paris IV)
    Inventors: Othman Bouloussa, Vincent Semetey, Francis Rondelez
  • Patent number: 8475780
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: July 2, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Gerrit Klaerner, Jerry M. Buysse, Mingjun Liu
  • Patent number: 8475779
    Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: July 2, 2013
    Assignee: Ares Trading SA
    Inventors: James Rasmussen, Jianxin Zhang, Sam Baldwin, Eric Zanelli, Bei Yu, Dustan Bonnin, Keith Johnson
  • Patent number: 8460646
    Abstract: To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 11, 2013
    Assignee: Purdue Research Foundation
    Inventors: Riyi Shi, Richard B. Borgens