Abstract: This invention is a burn remedial composition which is produced by mixing powder of the high heated abalone shells with sesame oil extracted from sesame, and its production method wherein it is characteristic that the grinding process of abalone shells heated at a temperature higher than 3000.degree. C. and the mixing process of the ground abalone shell powder and sesame oil are not performed in a stone or metallic vessel, but in a wooden vessel. A pharmaceutical additive can be added to aid the formation of a pharmaceutical type of burn remedial composition. When the burn remedial composition of the invention is applied to every degree of heat burn and fire burn for which there are few curing agents, especially to severe burns, the analgesic and antiphlogistic effects happen at that moment, the toxic materials in the injured region are eliminated within 24 hours and the injury is completely cured within 3-5 days.

Abstract: A therapeutic coolant for the local treatment of burn is provided wherein said coolant consisting of squalene, squalane, or mixtures thereof.A method of treating burn is provided wherein said method comprising :applying a therapeutic coolant cooled to a temperature range from -10 to -60.degree. C., said coolant selected from the group consisting essentially of squalene, squalane, or mixtures thereof.

Abstract: This invention relates to methods for delipidation of skin or hair through the use of cyclodextrins and cyclodextrin derivatives such as hydroxypropyl .beta.-cyclodextrin. The invention also relates to cerumen removal methods involving introduction of cyclodextrins to the ear canal, followed by complexation of the cyclodextrin with cerumen components, and removal of the resulting cyclodextrin complexes. The cyclodextrin components are used in a substantially oil-free powdered or aqueous formulation without detergents, soaps, solvents, oils or other lipid-like agents.

Abstract: There is described water-in-oil emulsions containing polysiloxane surface active agents which can be formulated into lotions for use in sunscreens and skin care products.

Abstract: Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate.This composition can be used topically to accelerate the scarring of wounds.

Abstract: The present invention provides compositions and methods for decreasing tissue breakdown in mammals. Specifically, tissue breakdown in a mammal can be decreased by the administration of composition, wherein said composition comprises from about 35% to 50% essential amino acids of which from about 18% to 30% are branched chain amino acids, and from about 50% to 65% non-essential amino acids, wherein the non-essential amino acids comprise from about 5% to 15% ALA and from about 15% to 45% GLN. In addition, the present invention provides methods of preparing compositions which are capable of meeting the specific metabolic needs of a patient experiencing catabolic tissue breakdown.

Abstract: This composition consists in an aqueous dispersion D, lamellar structure lipid vesicles encapsulating an aqueous phase E; it is characterised by the fact that the lipid phase forming the layers of the said vesicles is at least partly made up of a compound as formula (I): ##STR1## wherein R represents a linear saturated on unsaturated hydrocarbonated chain containing 9 to 17 carbon atoms. The compounds (I) have the advantage that they are easily biodegradable and of very low cytotoxicity.

Abstract: The present invention provides a method for combatting damage to a body tissue contacted to an alkali. The method comprising administering CO.sub.2 to the subject in an amount sufficient to produce an acidotic state in the tissue, the acidotic state serving to prevent alkali damage to the tissue. In a preferred embodiment of the invention, a subject is caused to inhale a mixture of 95%O.sub.2 and 5%CO.sub.2 for brief periods of time, followed by periods of breathing room air. The invention is particularly useful for treating alkaline injury of the esophagus caused by ingestion of alkaline material.

Abstract: This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen, in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

Abstract: Ozonides of terpenes are disclosed. Terpenes which are believed to be pharmacologically active when prepared in accordance with the present invention include: limonene, citronella, alpha-carotene, beta-carotene, Vitamin A, linalool, linalyl acetate, or squalene. Other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include geraniol, limonene, alpha-pinene, loganin, cymene, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, or germacranes. Still other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include labdanes, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, or hopanes.

Abstract: An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.

Abstract: A topical use pharmaceutical composition and a process for its preparation, comprising an improved enzyme-modified casein sol. Prior to being enzyme-modified, the casein is solubilized and neutralized by an alkali solution containing a molar weight percent ratio in the range of from 90:10 to 100:0, potassium hydroxide to sodium hydroxide. Said neutralization occurring for a time in the range of 5 to 35 minutes to allow for complete neutralization of the casein. The neutralized casein is then hydrolyzed or modified by enzymatic digestion by a proteolytic enzyme for a time sufficient to achieve a weight ratio of protein nitrogen to amino nitrogen in the range from 7:1 to 9:1. The improved enzyme-modified casein sol may then be mixed with stabilizing and pressuring agents, such as carrageenan, polyvinyl pyrrolidone, methyl paraben or propyl paraben.

Abstract: Topical compositions for application to the skin comprising a topically active agent which may be a cosmetic agent or a therapeutic agent, and a small, but carrier effective amount of a microbial polysaccharide polymer gel which is a beta-1,3 glucan-type polysaccharide.

Abstract: A topical emollient for the treatment of circulation induced lesions comprises a source of glucose and insulin. The topical emollient is utilized in a process wherein the emollient is applied to the affected surface for nourishment thereof and promotion of healing. The emollient also enhances the therapeutic benefits of other medicinal drugs which may be topically applied in conjunction with the insulin and glucose mixture.

Abstract: An antibiotic formulation useful in the treatment of burns and abrasions and adapted for topical application as a clinically water soluble foam, the process for preparing the formulation and a special dispenser system for applying same.

Abstract: A cysteine proteinase characterized in that it is immunologically distinct, has a molecular mass of about 25,000 and has a distinct net charge is disclosed. "Ananain" and "comosain" are such enzymes, which may be distinguished by their specificities for certain synthetic substrates.A process for the production thereof is also disclosed which comprises separation from pineapple plant material and purification. Such enzymes may be used in the debridement of eschar tissues.

Abstract: Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds.

Abstract: The invention provides a storage stable lyophilized collagen product comprising acid soluble purified native collagen in combination with platelet derived growth factors and a pharmaceutical composition for enhancing wound healing comprising an aqueous solution of water soluble acid-soluble purified native collagen and platelet derived growth factors.

Abstract: A composition and method of treating a traumatic injury by improving immunologic response and reducing a hypermetabolic response associated with those suffering from a traumatic injury such as a substantial burn, trauma, major surgery and the like and more particularly to those suffering from a substantial thermal burn injury to the skin or other areas through the administration of the composition of the invention to those suffering from the traumatic injury are disclosed. The composition comprises an intact protein, arginine, carbohydrate, lipid comprising the omega-3 fatty acids of fish oil, including eicosapentaenoic acid, and with linoleic acid limited to the amount necessary to prevent an essential fatty acid deficiency thereof and nutritionally necessary vitamins and minerals.

Abstract: The present invention provides a method for treating burns. The method includes injecting an effective amount of a surface-active copolymer into a human or animal with a burn. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b Hwhere a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O) constitutes approximately 50% to 90% by weight of the compound.

Abstract: A composition for the treatment of skin injuries is described including an antiseptic, a sapogenine, a proteolytic enzyme and a suitable vehicle. The composition is directly applied on the injury, forming a film which isolates and protects same from infection and suppresses pain. The film is self-adherent and transparent, which allows inspection of the healing injury, without the need of removing the film, as with bandages. The composition is antiseptic and microbiocidal, helps cicatrization and produces a biochemical debridement. The film allows the natural motility of the injury zone and produces a compression which helps to decrease or prevent edema. The film also allows the passage of air, preventing the production of anaerobiosis, decreasing the output of liquids, and preventing, in large injuries, dehydration and loss of electrolytes. The film can be removed merely by wetting.

Abstract: An external analgesic lotion containing active ingredients of methyl salicylate and camphor and menthol to relieve pain in muscles, joints, or viscera distal at the site of application by stimulating cutaneous sensory receptors and a method of making such lotion and being made from camphor and menthol crystals.

Abstract: The invention comprises a method of reducing rash formation and itching of skin caused by poison ivy. The method comprises breaking up a plant of the genus Plantago, preferably broadleaf Plantain, to release the sap therein and to form a fibrous pulp containing sap and applying an effective amount of the sap-containing pulp to the affected area of the skin.

Abstract: A wound-treating composition comprising a graft copolymer is disclosed along with a method of using the same.

Abstract: A method is provided of avoiding or minimizing inflammation at a painful freshly burned epidermal skin site, which comprises applying on the skin site promptly before the appearance of overt inflammation, an anti-inflammatory composition in homogeneous non-alcoholic aqueous solution form consisting essentially of distilled hamamelis water, magnesium sulfate, and copper sulfate to allow for transdermal absorption of the composition at the skin site for a period sufficient to achieve local relief of inflammatory symptoms.

Abstract: An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.

Abstract: A melanin inhibitor comprising as the reactive component a cinnamic acid derivative of the formula (I) or (II): ##STR1## in which R' represents an acyl group having 2 to 6 carbon atoms, R.sub.1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group or an alkenyl group, and R.sub.2 represents a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, a cycloalkyl group or an alkenyl group.The melanin inhibitors according to the invention are locally applied to affected portions such as of freckles and pigmentary deposits after sunburn without giving any stimulative or allergic troubles to the skin.

Abstract: Processes for producing aloe extracts including the separation of the leaves of the aloe plant into distinct portions. In particular, a first process is described for producing an aloe extract which is substantially free of anthraquinone-rich yellow sap and a second process is described for extracting the active chemical substance in the aloe plant.The active chemical substance in the aloe plant is extracted from aloe leaves and its characteristic properties are described.

Abstract: The present invention relates to styling agents comprising adhesive copolymers along with a volatile diluent useful in products such as shampoos and conditioners which provide hair styling hold. The monomer components in these copolymers are randomly distributed in the copolymer chain, preferably to form a substantially linear chain. Preferably, at least one of the monomer components is selected from vinyl pyridine, acrylate amides and methacrylate amides and one of the other monomer components is selected from butadiene, isoprene, isobutene, acrylate esters, methacrylate esters, vinyl alkyl ethers, alkyl-substituted butadienes, and chloroprene. These copolymers also have a single glass transition temperature within the temperature range of from about 0.degree. C. to about 150.degree. C. The volatile diluents useful in these styling agents can be hydrocarbons, esters, ethers, amines, alkyl alcohols, or volatile silicon derivatives.

Abstract: A dimensionally stable alginate hydrogel foam wound dressing that absorbs wound exudate without any appreciable swelling. The wound dressing is formed-in-place in the wound cavity or on the wound surface from a reactive composition that foams as it gels. The water-insoluble alginate hydrogel foam based wound dressing is made by mixing together the ingredients of a two component system; applying the resulting composite liquid mixture to a wound site; and allowing the composite mixture to react. One component contains an aqueous suspension of certain di-or trivalent metal salts and an effervescent compound. The second component contains an aqueous solution of a biocompatible, water-soluble acid. At least one compound, and preferably both, contain a water soluble alginate.

Abstract: This invention relates to porous, biodegradable materials in which the pore size, biodegradation rate, and pore volume fraction are controlled and within values at which skin contraction rates around an implant-containing wound are delayed or slowed.

Abstract: Processes for producing aloe extracts including the separation of the leaves of the aloe plant into distinct portions. In particular, a first process is described for producing an aloe extract which is substantially free of anthraquinone-rich yellow sap and a second process is described for extracting the active chemical substance in the aloe plant.The active chemical substance in the aloe plant is extracted from aloe leaves and its characteristic properties are described.

Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.

Abstract: The present invention relates to a composition comprising at least one pharmaceutically acceptable monosaccharide containing from about 3 to 7 carbon atoms and a pharmaceutically acceptable film forming agent.

Abstract: An improved salve having medicinal properties and method of preparing the same, said salve comprising olive oil, beeswax, camphor, pine rosin, and anhydrous lanolin.

Abstract: According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, and open sores, and such mixture comprises: the therapeutic agent being the extract from the dried leaves of the Eupatorium plant; a preservative chosen from the group consisting of a sulfa-derivative such as sulfathiazole and an alcohol amine; a skin softener such as an oil; and an oil soluble base. An inert pigment such as zinc oxide and a fragrance such as a perfume may be added. According to a specific illustrative embodiment of the present invention, the skin therapeutic mixture comprises about 7.4% by weight of the extract from the dried leaves of the Eupatorium plant as the therapeutic agent; about 3.7% by weight of sulfathiazole as the preservative; about 14.2% by weight of zinc oxide as the inert white pigment; and about 74.7% by weight of petrolatum.

Abstract: In accordance with the present invention, a method and composition is provided for treating pathological hydrophobic interactions in biological fluids in which there is acute impairment of the circulation, especially the microcirculation. More particularly, the present invention relates to compositions and methods for treating circulatory diseases comprising using certain ethylene oxide-propylene oxide condensation surface active copolymers either alone or in combination other compounds.Also contemplated in the present invention is a method for preserving a suspension of platelets. The method comprises adding an effective amount of a surface active copolymer.The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula;HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b Hwherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.

Abstract: According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, and open sores, and such mixture comprises: the therapeutic agent being the extract from the dried leaves of the Aloe Vera plant; a preservative chosen from the group consisting of a sulfaderivative such as sulfathiazole and an alcohol amine; a skin softener such as an oil; and an oil soluble base. An inert pigment such as zinc oxide and a fragrance such as a perfume may be added. According to a specific illustrative embodiment of the present invention, the skin therapeutic mixture comprises about 7.4% by weight of the extract from the dried leaves of the Aloe Vera plant as the therapeutic agent; 5% by weight of sulfathiazole as the preservative; about 14.2% by weight of zinc oxide as the inert white pigment; and about 73.4% by weight of petrolatum.

Abstract: According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, and open sores, and such mixture comprises: the therapeutic agent being the extract from the dried leaves of the Matico plant; a preservative chosen from the group consisting of a sulfaderivative such as sulfathiazole and an alcohol amine; a skin softener such as an oil; and an oil soluble base. An inert pigment such as zinc oxide and a fragrance such as a perfume may be added. According to a specific illustrative embodiment of the present invention, the skin therapeutic mixture comprises about 2% to 35% by weight of the extract from the dried leaves of the Matico plant as the therapeutic agent; about 2% to 15% by weight of sulfathiazole as the preservative; about 5% to 10% by weight of zinc oxide as the inert white pigment; and about 40% to 91% by weight of petrolatum.

Abstract: A stable hydrocortisone-based composition comprises hydrocortisone solubilized in a mixture of an aliphatic alcohol, propyleneglycol and dimethyl coco-benzylammonium chloride.

Abstract: A process is described for extracting a pharmaceutically active polysaccharidic substance from the aloe plant.The pharmaceutically active polysaccharidic substance and its characteristic properties are described.

Abstract: Skin treatment compositions are provided which counteract moisture loss and promote healing of burned or sunburned skin which include a unique moisturizing component formed of polyglycerylmethacrylate, glycerine, allantoin, panthenol, amino acid complex, and fibronectin.

Abstract: A method of treating burns and scald wounds on the human body by rapid cooling which includes spraying liquid from a hand-held container and directing the liquid to the portion of the human body to be treated to form a film of liquid and then spraying and directing onto the film of liquid from a second hand-held container a refrigerant at a temperature low enough and a flow rate high enough to freeze a substantial portion of the film of liquid so that the human body is rapidly cooled by the heat absorbed from the frozen film. An apparatus accomplishing the method includes a portable hand-holdable support with two containers, one having sprayable liquid and the other having a refrigerant.

Abstract: Pharmaceutical compositions which are suitable for topical application in the treatment of bacterial and/or fungal infections are described. The compositions comprise a synergistic mixture of a silver compound and an azole derivative together with a pharmaceutically acceptable carrier therefor. The compositions may be applied topically in the treatment of burns ulcers and other skin lesions, general skin infections and also in the treatment of infections of the mucous membranes. Preferred compositions contain silver sulphadiazine and clotrimazole or metronidazole. The compositions may be applied as ointments, gels, pessaries, tablets and the like.

Abstract: Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.

Abstract: A pharmaceutical preparation for the treatment of, e.g. ulcers, burns and skin diseases contains, as essential ingredients, from 5 to 25% by weight of Peru Balsam and from 0.01 to 0.20% by weight of silver nitrate. The preparation may be administered enterally or topically.

Abstract: Heavy metal salts of hyaluronic acid have been prepared. In particular, this invention is directed to silver, gold, cerium and tungsten salts of hyaluronic acid. These heavy metal salts of hyaluronic acid are useful as antimicrobial agents. Gold hyaluronate may also be used to treat arthritis. This invention also concerns methods of making the silver salt of hyaluronic acid as well as compositions containing silver hyaluronate or gold hyaluronate. The invention also concerns composition containing heavy metal salts having radioactively labelled hyaluronate moieties.

Abstract: Process for producing aloe extracts including the separation of the leaves of the aloe plant into distinct portions. In particular, a first process is described for producing an aloe extract which is substantially free of anthraquinone-rich yellow sap and a second process is described for extracting the active chemical substance in the aloe plant.The active chemical substance in the aloe plant is extracted from aloe leaves and its characteristic properties are described.

Abstract: Bio-and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing. Detailed procedures and various products are described including gloves and sleeves and tubes with or without adhesive to facilitate formation of sheet materials into various forms and products. The products may have small holes provided therein for the rapid passage of accumulated fluid away from the wound or infusion of liquid materials to the wound site.

Abstract: According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, open sores, and other conditions and such mixture comprises: the therapeutic agent being the extract from the dried leaves of the Eupatorium plant; a preservative chosen from the group consisting of a sulfa-derivative such as sulfathiazole and an alcohol amine; a skin softener such as an oil; and an oil soluble base. An inert pigment such as zinc oxide and a fragrance such as a perfume may be added. According to a specific illustrative embodiment of the present invention, the skin therapeutic mixture comprises about 7.4% by weight of the extract from the dried leaves of the Eupatorium plant as the therapeutic agent; 3.7% by weight of sulfathiazole as the preservative; about 14.2% by weight of zinc oxide as the inert white pigment; and about 74% by weight of petrolatum.