Analysis, Diagnosis, Measuring, Or Testing Product (e.g., Specimen Preparation, Microscope Slide Smearing) Patents (Class 427/2.11)
  • Patent number: 7713474
    Abstract: A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: May 11, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Lloyd S. Schulman, Michael J. Pugia, Spencer Lin, Karlheinz Hildenbrand
  • Patent number: 7709047
    Abstract: A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular component of a tissue section and the transfer surface is a film that can be focally altered to adhere the target to the transfer surface. Subsequent separation of the film from the tissue section selectively removes the adhered target from the tissue section. The transfer surface is activated from within the target to adhere the target to the transfer surface, for example by heating the target to adhere it to a thermoplastic transfer surface. Such in situ activation can be achieved by exposing the biological sample to an immunoreagent that specifically binds to the target (or a component of the target).
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 4, 2010
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael R. Emmert-Buck, Michael Anthony Tangrea, Robert F. Bonner, Rodrigo Chuaqui, Thomas J. Pohida
  • Patent number: 7704543
    Abstract: This invention provides a new method of obtaining a high density, reproducible and uniform coverage of a solid surface, compounds suitable for such a method and methods of preparing such compounds. This invention further relates to methods of the chemical modification (carboxylation) of solid surfaces and their subsequent use for the attachment of amine-containing molecules including DNA, proteins and other polymers.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: April 27, 2010
    Assignee: Illumina Cambridge Limited
    Inventors: Milan Fedurco, Anthony Romieu, Gerardo Turcatti
  • Patent number: 7695752
    Abstract: A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a transfer surface. Also described is an automated system for transferring tissue from a tissue sample to a transfer substrate. The system includes means for holding a tissue section that includes targets specifically stained with an absorptive stain thereby resulting in a stained tissue surface, and a flexible transfer film that includes a lower thermoplastic layer in sufficient thermal contact with the stained tissue surface; an irradiating assembly configured to provide a predetermined uniform light dose to the entire tissue section; and means for applying a constant pressure to the transfer film during irradiation.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: April 13, 2010
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Robert F. Bonner, Thomas J. Pohida, Michael R. Emmert-Buck, Michael Anthony Tangrea, Rodrigo F. Chuaqui
  • Publication number: 20100086992
    Abstract: A biosensor chip for sensing a target molecule, includes: a substrate having a surface with a sensing area; and adhesive material for immobilizing a mollicute having a cell membrane on the sensing area. The chip may includes cell-resistant material for preventing the mollicute from being immobilized on those parts of the surface of the substrate that do not belong to the sensing area. Further, the adhesive material may comprise a first adhesive material for immobilizing a body of the mollicute on the sensing area and a second adhesive material for immobilizing a tip of the mollicute on the surface of the substrate.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 8, 2010
    Applicant: Fujirebio Inc.
    Inventors: Michael Himmelhaus, Spencer Spratt
  • Publication number: 20100085566
    Abstract: Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 8, 2010
    Inventor: Brian T. Cunningham
  • Patent number: 7691623
    Abstract: The present invention relates to a device for performing immuno assays (“biochip” or “lab on chip” respectively), a procedure for its fabrication and the use of the device for performing immuno assays. Furthermore the present invention relates to the use of a photo lithographically patternable dry film photo resist based on a material with functional chemical groups for the immobilization of biomolecules.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 6, 2010
    Inventors: Gerhard Jobst, Thomas Gamp
  • Publication number: 20100081579
    Abstract: A method for preserving a sample is described. A method for preserving a sample device such as microarrays, slides and membranes is described. The preservation is achieved by applying a coating composition to a sample or sample device, and curing the coating composition. Candidate coating materials for forming the coating compositions are described. Preferably, the coating composition is an optically clear, solidifying solution. Also described are preservation kits which provide materials and instructions for the preservation of sample devices. Calibration devices are also described.
    Type: Application
    Filed: May 20, 2009
    Publication date: April 1, 2010
    Applicant: INVITROGEN CORPORATION
    Inventors: Paul BUSHWAY, Laurence Warden, Todd Peterson, David E. Kohne, Juan Yguerabide
  • Publication number: 20100069259
    Abstract: A method for archiving sample devices such as microarray slides and membranes is described using an optically clear, solidifying solution. Also described are related methods and kits.
    Type: Application
    Filed: June 19, 2009
    Publication date: March 18, 2010
    Applicant: INVITROGEN CORPORATION
    Inventors: Paul BUSHWAY, Laurence WARDEN, Todd PETERSON, David E. KOHNE, Juan YGUERABIDE
  • Patent number: 7676258
    Abstract: A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of citric or other alpha-hydroxy acid which enhances tissue structures, such as cellular nuclei, in such images. Such concentration may be 3-20% acid, and preferably 5% acid.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: March 9, 2010
    Assignee: Lucid, Inc.
    Inventor: Jay M. Eastman
  • Patent number: 7651864
    Abstract: A method of preparing a coating solution for a glucose sensing membrane, the method comprising preserving a first solution containing an oxidizing enzyme or a reducing enzyme of glucose and a reagent for generating a substance for coloring a coloring agent dissolved in a buffer solution, preserving a second solution containing a mixed solution of an alcohol solution of the coloring agent and a solution of a membrane-forming polymer compound, and mixing the first solution and the second solution.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: January 26, 2010
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Shingo Kasai, Kayoko Oomiya, Ikuo Uematsu, Ichiro Tono
  • Patent number: 7648739
    Abstract: A substrate having a surface with reversibly switchable properties. The surface comprises a nanolayer of a material that switches from a first conformation state to a second conformation state when an external stimulus is applied. When the nanolayer is in the first conformation state, the surface is characterized by a first property, and when the nanolayer is in the second conformation state, the surface is characterized by a second property.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: January 19, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Joerg Lahann, Samir S. Mitragotri, Robert S. Langer
  • Patent number: 7638157
    Abstract: A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A ?-D-glucose oxidase and polyvinyl alcohol bearing styrylpyridinium groups are placed in 100 ?l of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: December 29, 2009
    Assignee: Chung Yuan Christian University
    Inventors: Shen-Kan Hsiung, Jung-Chuan Chou, Tai-Ping Sun, Wen-Yaw Chung, Li-Te Yin, Chung-We Pan
  • Patent number: 7632539
    Abstract: Bi12MO20 material particles with a diameter of 0.1 to 2 ?m, which are filled in an aerosolization chamber, are shaken/agitated together with carrier gas in a high-pressure gas cylinder which stores the carrier gas, thereby being aerosolized. The aerosolized Bi12MO20 material particles are injected together with the carrier gas onto a substrate from a nozzle in a film-forming chamber, the nozzle including a narrow opening, and the Bi12MO20 material particles are deposited onto the substrate, thereby being formed into a film.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: December 15, 2009
    Assignee: FUJIFILM Corporation
    Inventor: Kiyoteru Miyake
  • Patent number: 7629016
    Abstract: The invention relates to a photochemical process for the preparation of an activated polymer surface having an active fluoro group using 1-fluoro-2-nitro-4-azidobenzene to form the activated polymer surface and then immobilizing a biomolecule thereon by forming a covalent bond between the activated polymer surface and the biomolecule.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: December 8, 2009
    Assignee: Council of Industrial and Scientific Research
    Inventor: Pradip Nahar
  • Publication number: 20090291195
    Abstract: An analytic plate or other substrate having a permanent etchable, laserable, and/or developable marking surface coating (referred to herein as an “etchable coating” or as a “developable coating”) that is present on at least a portion of any side or surface thereof and is used to deposit a permanent indicium thereon, and a method of using the analytic plate or substrate.
    Type: Application
    Filed: July 29, 2009
    Publication date: November 26, 2009
    Inventor: Lee H. Angros
  • Patent number: 7602996
    Abstract: A microscope system and method is described for determining a position of an area of an object within the complete object, wherein the image of the area of the object is contained within a field of view of a microscope. Image data representing a low magnification image of the complete object is available for use in the method, and may be acquired using a low magnification image data source such as a scanner. In a preferred embodiment, the method is implemented in the form of a computer program running on a workstation, which displays, on a display screen the field of view image, and the image of the complete object, in which the position of the area of the object in field of view is highlighted.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: October 13, 2009
    Assignee: Hamamatsu Photonics K.K.
    Inventor: John R. Maddison
  • Patent number: 7582422
    Abstract: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected ?-modified, ?-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: September 1, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Todd C. Strother, Lloyd M. Smith, Robert J. Hamers
  • Patent number: 7569246
    Abstract: The invention relates to a method for preparing a biological material for examination with a microscope, comprising the steps of: applying a UV laser light absorbing transparent film onto a surface of the biological material for smoothing out irregularities on the surface of the biological material in order to improve visual characteristics of the biological material; and cutting the biological material together with the UV laser light absorbing transparent film with a UV laser, thereby preparing the biological material for examination.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: August 4, 2009
    Assignee: P.A.L.M. Microlaser Technologies AG
    Inventors: Karin Schuetze, Christer Busch, Tone Bjørnsen
  • Publication number: 20090191616
    Abstract: A biosensor structure and a method for fabricating the same are described. The biosensor structure for detecting at least a single cell includes a substrate with an insulating surface, a conductive layer and a plurality of capture molecules. The conductive layer is disposed on the substrate, and has a first pattern and a second pattern separated from each other. The first pattern includes a plurality of first finger configurations, and the second pattern includes a plurality of second finger configurations, so as to form interdigitated array. The capture molecules are immobilized on the conductive layer, such that the cell that is bound specifically to the capture molecules on two adjacent first and second finger configurations is detected. The biosensor structure is feasible for real-time (<3 min), specific, and quantitative targeted cell detection down to a single cell.
    Type: Application
    Filed: August 27, 2008
    Publication date: July 30, 2009
    Applicant: National Tsing Hua University
    Inventors: Yi-Chun Lu, Tri-Rung Yew, Hwan-You Chang, Ya-Shuan Chuang
  • Publication number: 20090186411
    Abstract: The invention relates to a cell culture apparatus for cells, characterized by a surface composed of an unstructured elastomer. It is thus possible for cells to be cultured under close to natural conditions in relation to their environmental elasticity. A method for producing an apparatus according to the invention is disclosed, as is a cell culture method using such an apparatus.
    Type: Application
    Filed: June 14, 2007
    Publication date: July 23, 2009
    Applicant: Forschungszentrum Juelich GmbH
    Inventors: Bernd Hoffmann, Bodo Borm, Rudolf Merkel
  • Patent number: 7563623
    Abstract: It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supply. The present invention provides a biosensor comprising a substrate on which a hydrophilic polymer having a reactive group capable of binding to a physiologically active substance is immobilized via a compound represented by the following formula (1), said compound at a concentration of 1 mM being dissolved in water at 25° C.: X-L-Y??(1) wherein X represents a group capable of binding to metal, L represents a linking group, and Y represents a functional group to which the hydrophilic polymer is bound.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: July 21, 2009
    Assignee: FUJIFILM Corporation
    Inventors: Toshihide Ezoe, Taisei Nishimi, Yukou Saito
  • Patent number: 7564027
    Abstract: The present invention provides a device, system, and associated methods to actively or passively sample air by directing it onto the surface of a porous light-absorbing semiconductor, for example, a desorption/ionization on porous silicon (“DIOS”) chip. Upon adsorption of an analyte, the surface may be analyzed directly by laser desorption/ionization time-of-flight mass spectrometry. Because the process of laser desorption/ionization and subsequent mass detection does not require elevated temperatures, thermal degradation of analytes is avoided.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: July 21, 2009
    Assignee: Waters Investments Limited
    Inventors: Jeffrey W. Finch, Chris L. Stumpf, Bruce J. Compton
  • Patent number: 7560258
    Abstract: Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect proteins and to measure their concentration, binding affinity, and kinetics. Peptides, proteins, fusion proteins, protein complexes, and the like, are labeled with an acrylic moiety and attached to acrylic-functionalized glass surfaces through a copolymerization with acrylic monomer. The specific attachment of GST-green fluorescent protein (GFP) fusion protein was more than 7-fold greater than the nonspecific attachment of non-acrylic labeled GST-GFP. Surface-attached GST-GFP (0.32 ng /mm2) was detectable by direct measurement of GFP fluorescence and this lower detection limit was reduced to 0.080 ng/mm2 using indirect antibody-based detection. The polyacrylamide-based surface attachment strategy was also used to measure the kinetics of substrate phosphorylation by the kinase c-Src.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: July 14, 2009
    Assignees: Wisconsin Alumni Research Foundation, The University of Chicago
    Inventors: Shawn B. Brueggemeier, Stephen J. Kron, Sean P. Palecek
  • Publication number: 20090175765
    Abstract: A method of preventing non-specific adsorption of proteins onto a surface can include providing a substrate that has a surface on which surface groups are attached. A solution can be applied to the surface that includes a protective reagent having a terminal functional group exhibiting a dipole moment. A monolayer comprising the protective reagent is assembled on the surface by reacting the protective reagent with the surface groups, thereby creating a protected surface. The protective reagent alone is sufficient to confer to the protected surface an increased resistance to adsorption of proteins.
    Type: Application
    Filed: October 20, 2008
    Publication date: July 9, 2009
    Inventors: Joel M. Harris, Henry S. White, Joshua R. Wayment, Ryan J. White
  • Publication number: 20090156939
    Abstract: Provided herein are composite passive layers for ultrasound transducers having acoustic properties that can be easily tailored to the needs of the transducer application using current microfabrication techniques. In an embodiment, a passive layer comprises metal posts embedded in a polymer matrix or other material. The acoustic properties of the passive layer depend on the metal/polymer volume fraction of the passive layer, which can be easily controlled using current microfabrication techniques, e.g., integrated circuit (IC) fabrication techniques. Further, the embedded metal posts provide electrical conduction through the passive layer allowing electrical connections to be made to an active element, e.g., piezoelectric element, of the transducer through the passive layer. Because the embedded metal posts conduct along one line of direction, they can be used to provide separate electrical connections to different active elements in a transducer array through the passive layer.
    Type: Application
    Filed: December 18, 2007
    Publication date: June 18, 2009
    Inventors: Alain Sadaka, Jian R. Yuan
  • Patent number: 7547424
    Abstract: An apparatus for placing a hydrophobic barrier on an examination slide including a vessel, a printer block having a printing surface to form a hydrophobic barrier on the examination slide in a specified pattern, a slide holder, and a reversible actuator. The invention also includes a method for placing a hydrophobic barrier on an examination slide in a specified pattern.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: June 16, 2009
    Assignee: Van Andel Research Institute
    Inventors: Brian Brummeler Haab, David Kruithoff
  • Publication number: 20090148348
    Abstract: A method of treating a plastic surface with fluorine gas to decrease adsorption of hydrophobic solute molecules to the surface is provided. The method can include treating a surface with a first gas comprising fluorine gas and a second gas comprising oxygen gas, water vapor, or both oxygen gas and water vapor. Plastics treated using the method provide useful drug discovery and biochemical tools for the testing, handling, and storage of solutions containing low concentrations of hydrophobic solutes. Microfluidic devices containing treated plastic interior surfaces and methods of using such devices to make concentration-dependent measurements are also described.
    Type: Application
    Filed: August 10, 2006
    Publication date: June 11, 2009
    Applicant: EKSIGENT TECHNOLOGIES, LLC
    Inventors: Kenneth I. Pettigrew, Pang-Jen Craig Kung, Joshua T. Stecher, Gregory Fenton Smith, Hugh C. Crenshaw
  • Publication number: 20090142472
    Abstract: Synthetic nanopore fabrication methods and structures are provided. Nanoscale transistor fabrication methods and structures are provided.
    Type: Application
    Filed: July 14, 2006
    Publication date: June 4, 2009
    Inventors: Phillip W. Barth, Thomas Edward Kopley, Nicolas J. Moll, Ying-Lan Chang
  • Publication number: 20090120796
    Abstract: The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods, inter-alia, make use of a device comprising a fluidic chip comprising a planar array of channels through which a liquid comprising a species of interest can be made to pass with at least one rigid substrate connected thereto such that at least a portion of a surface of the substrate bounds the channels, and an ion-selective membrane is attached to at least a portion of the surface of the substrate, which bounds said channels, or which bounds a portion of a surface of one of said channels. The device comprises a unit to induce an electric field in the channel and a unit to induce an electrokinetic or pressure driven flow in the channel.
    Type: Application
    Filed: September 26, 2008
    Publication date: May 14, 2009
    Inventors: Jongyoon Han, Yong-Ak Song, Jeong Hoon Lee
  • Patent number: 7517546
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 14, 2009
    Assignee: Bayer Technology Services GmbH
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Patent number: 7501289
    Abstract: It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: March 10, 2009
    Assignee: FUJIFILM Corporation
    Inventors: Toshiaki Kubo, Toshihide Ezoe
  • Publication number: 20090061506
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups.
    Type: Application
    Filed: September 8, 2008
    Publication date: March 5, 2009
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schurmann-Mader, Markus Ehrat, Samuele Tosatti
  • Publication number: 20090036768
    Abstract: Medical devices with radiopaque markers, and related systems and methods are disclosed.
    Type: Application
    Filed: November 16, 2007
    Publication date: February 5, 2009
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Ashley Seehusen, Christopher Nardone, Mark Girard, Mark L. Adams, Todd Beaupre, Raymond J. Lareau
  • Patent number: 7485333
    Abstract: A method of coating a stent using a mounting device is provided.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: February 3, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Stephen D. Pacetti, Plaridel K. Villareal
  • Publication number: 20090028792
    Abstract: Oxide, oxysulfide, halide or phosphate host particles with a self-assembled organophosphonate monolayer covalently bonded thereto. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.
    Type: Application
    Filed: July 19, 2008
    Publication date: January 29, 2009
    Applicant: The Trustees of Princeton University
    Inventors: Jeffrey Schwartz, Christopher A. Traina
  • Publication number: 20080311004
    Abstract: There is provided a test strip for testing a fluid sample, including a sample cavity configured to receive the fluid sample and an ultrasonically-spread reagent layer arranged on at least one surface of the sample cavity. There is also provided a method for making a biosensor, including providing a substrate having a region for receiving a sample; dispensing a liquid substance on at least one surface of the region for receiving a sample; and subjecting the substrate to ultrasonic vibrations to quickly and uniformly spread the liquid substance on the at least one surface of the region for receiving a sample.
    Type: Application
    Filed: June 18, 2007
    Publication date: December 18, 2008
    Inventors: Steven B. GILMOUR, Keith A. Harvey
  • Publication number: 20080291424
    Abstract: A thin, deformable member may be fixed at one end, while another portion of the member rests on a hydrogel substance whose thickness changes depending on a characteristic of a liquid that permeates the hydrogel. When the hydrogel changes thickness and causes part of the member to tilt, a reflective surface on the member may reflect light in a different direction. Appropriate sensors may detect the change in the direction of the reflected light, allowing determination of the change in thickness, which in turn permits determination of the relevant characteristic of the liquid.
    Type: Application
    Filed: May 25, 2007
    Publication date: November 27, 2008
    Inventor: Ming Lei
  • Patent number: 7455874
    Abstract: The present invention relates to an enzyme electrode arrangement comprising a substrate with a surface roughness in the range of 20 nm to 10 microns, a metal electrode, an ultrathin semipermeable membrane with a thickness in the range of 10-100 nm and at least one enzyme membrane, a method for the fabrication of such arrangement and a biosensor arrangement comprising such electrode arrangement.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: November 25, 2008
    Inventors: Isabella Moser, Gerald A. Urban, Anastasia Zacharopoulou, Panagiota S. Petrou
  • Patent number: 7455816
    Abstract: The invention relates to a method for coating a support plate for carrying out functional tests on biological cells, to a support plate for carrying out functional tests on biological cells and to the use of corresponding support plates for carrying out functional tests on biological cells.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: November 25, 2008
    Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitaet Tuebingen
    Inventors: Heiko Steuer, Markus Templin, Britta Kanzok, Cornelia Kuschel, Brigitte Angres
  • Publication number: 20080274538
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Application
    Filed: July 17, 2008
    Publication date: November 6, 2008
    Applicant: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 7442403
    Abstract: The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: October 28, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: Jose-Maria Sansinena, Antonio Redondo, Basil I. Swanson, Chanel Kitmon Yee, Annapoorna R. Sapuri/Butti, Atul N. Parikh, Calvin Yang
  • Publication number: 20080255305
    Abstract: A silicone polymer having a modified surface is described, wherein said modification consists of a covalently attached water soluble polymer bearing an activating group, wherein said activating group reacts with reactive functionalities on one or more biological molecules so that said one or more biological molecules become covalently attached to said silicone polymer. The modified silicones are reacted with biological molecules to make them more biocompatible for use in biodiagnostic, biosensor or bioaffinity applications, or for coatings for in vivo transplantation or for liners exposed to biological broths.
    Type: Application
    Filed: May 17, 2005
    Publication date: October 16, 2008
    Applicant: McMASTER UNIVERSITY
    Inventors: Michael A. Brook, Heather Sheardown, Hong Chen
  • Publication number: 20080220989
    Abstract: A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first self-assembled monolayer by micro-titration technique. After the bonding reaction between the first biomedical molecular point and the first self-assembled monolayer, a second self-assembled monolayer is deposited on the surface of the first self-assembled monolayer by evaporation. The second self-assembled monolayer attached on the plurality of first biomedical molecular dots and the first self-assembled monolayer not bonded to the substrate are removed, so that the first biomedical molecular dots immobilized on the first self-assembled monolayer are exposed. Finally, a second biomedical molecular layer is immobilized on the exposed portions of the first biomedical molecular dots.
    Type: Application
    Filed: September 28, 2007
    Publication date: September 11, 2008
    Applicant: NATIONAL TSING HUA UNIVERSITY
    Inventors: Fan Gang Tseng, Hsin Yi Hsieh, Chun Lung Wu
  • Publication number: 20080203618
    Abstract: The present application relates to an apparatus and method for non-contact collapsing of a porous material on a nonporous substrate.
    Type: Application
    Filed: November 30, 2007
    Publication date: August 28, 2008
    Applicant: Applera Corporation
    Inventors: Douwe D. Haga, Julio P. Focaracci, Nelson G. Todd
  • Patent number: 7405072
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 29, 2008
    Assignee: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Publication number: 20080174775
    Abstract: Methods of analysis, and compositions relating to such, to determine the presence or absence of an analyte in a sample utilizing a composite substrate which facilitates surface enhanced Raman spectroscopy through the use of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented. Additionally, substrates which contain ‘hot spots’ of the form ‘metal/analyte/metal’ and substrates which facilitate the formation of ‘hot spots’ of the form ‘metal/analyte/metal’ are presented as well as methods for making these substrates.
    Type: Application
    Filed: January 23, 2008
    Publication date: July 24, 2008
    Inventors: Martin Moskovits, Seung Joon Lee, Ioana Pavel
  • Patent number: 7393448
    Abstract: The present invention relates to a method of non-covalently binding a compound to a sensor surface. The method comprises adsorbing a hydrophobin-like substance to at least a part of the sensor surface, such as an electrode. The invention further provides a sensor having a surface, at least a part of which is provided with a coating of a hydrophobin-like substance that comprises a non-covalently bonded compound.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: July 1, 2008
    Assignee: Applied NanoSystems B.V.
    Inventors: Ewa Maria Rogalska, Renata Bilewicz, Denis Etienne Marie André Tagu, Alain Georges Ghislain Walcarius, Johannes Wemer, Karin Scholtmeijer, Rick Rink, Harm Jan Hektor
  • Patent number: 7390649
    Abstract: The invention relates to sensor chips with multiple layers of polysiloxane with improve homogeneity.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: June 24, 2008
    Assignee: Micronas Holding GmbH
    Inventors: Holger Klapproth, Jürgen Rühe, Sonia Mohry
  • Publication number: 20080145862
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner. Additionally, peptides that adopt helical structures are synthesized on a substrate surface and arrays are created having one or more features containing peptides capable of forming helixes.
    Type: Application
    Filed: December 19, 2006
    Publication date: June 19, 2008
    Inventor: Edelmira Cabezas