For Mineralized Body Part (e.g., Bone, Tooth, Crown, Hip) Patents (Class 427/2.26)
  • Patent number: 10369247
    Abstract: Adhesive articles that include a substrate and a silicone adhesive are disclosed. The articles also include a polymer containing poly(propylene oxide) units and optionally poly(ethylene oxide) units and having a number average molecular weight of at least 1000 grams per mole. The polymer may either be incorporated into the substrate or may be used as a primer on the substrate. If the polymer includes poly(ethylene oxide) units, the copolymer typically has a weight ratio of poly(ethylene oxide) to poly(propylene oxide) of up to 3:1, or if the copolymer has a number average molecular weight of at least 10,000 grams per mole, the weight ratio of poly(ethylene oxide) to poly(propylene oxide) is up to 2:1. Methods of making the adhesive articles are also disclosed.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 6, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Simon S. Fung, Michael D. Determan, Kiu-Yuen Tse, David T. Amos
  • Patent number: 10219986
    Abstract: A method of forming a stabilized calcium phosphate moiety for use in dental or biomedical applications includes providing a solution or dispersion including a calcium salt and reacting an organic phosphate having a polymerizable methacrylate or vinyl group with the solution or dispersion in order to form the calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group, which may be the same group. A polymerizable composite system having a stabilized calcium phosphate formed according to the method is also provided.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: March 5, 2019
    Assignee: Modern Ideas LLC
    Inventors: Sunny Skaria, Kenneth Berk
  • Patent number: 10106880
    Abstract: Embodiments disclosed herein generally relate to modifying a material's surface chemistry and surface profile using a pulsed laser. In embodiments, a system comprises: a material, the material including a surface portion having a surface chemistry; an enclosure, the enclosure containing a gaseous mixture having a non-atmospheric composition; and a pulsed laser configured to emit at least one laser pulse, the at least one laser pulse being directed to pass through the gaseous mixture onto the surface portion thereby modifying the surface chemistry of the surface portion.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: October 23, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Steven Seghi, Jason Kalishek
  • Patent number: 9910037
    Abstract: The present disclosure relates to compositions, methods, and kits for the rapid detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using vancomycin—PVA backbone complexes to capture and/or concentrate microorganisms in an aqueous sample, such as gram positive and/or gram negative bacteria in solution.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 6, 2018
    Assignee: Iris International, Inc.
    Inventors: Edward Jablonski, Carl Hulle
  • Patent number: 9907656
    Abstract: To provide a prosthetic member that is less likely to degrade its mechanical properties even when using it in the presence of squalene, and a method of producing the same. The prosthetic member in the present invention includes a substrate exhibiting excellent antioxidant properties and including an antioxidant and a polymer material, and a polymer film(s) covering a surface of the substrate and comprising a (meth)acrylate compound. The method for producing the prosthetic member in the present invention includes the steps of: forming a substrate comprising an antioxidant and a polymer material, cleaning a surface of the substrate with a cleaning liquid, and covering the cleaned surface of the substrate with a polymer film(s) comprising a (meth)acrylate compound.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: March 6, 2018
    Assignee: KYOCERA CORPORATION
    Inventor: Masayuki Kyomoto
  • Patent number: 9861829
    Abstract: A method and device to apply a cold plasma to a substance at a treatment surface of a patient to cause electroporation of the substance into cells of the patient. The substance can be previously applied to the treatment surface. Alternatively, the substance can be placed in a foam-like material within a tip that passes the cold plasma from the cold plasma device to the treatment area. The tip can be a cannula device with an aperture at the distal end. The cannula device can also have apertures along a portion of the length of the cannula device.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: January 9, 2018
    Assignee: Plasmology4, Inc.
    Inventors: Marc C. Jacofsky, David J. Jacofsky, Gregory A. Watson
  • Patent number: 9814558
    Abstract: A spinal implant device has a synthetic or metallic or a combination thereof of these materials in an implant body structure and stem cells in a coating, or a sheet, wrap or a membrane wrap applied to surfaces on the implant body structure or alternatively filled with a plug of stem cell laden material. The implant body structure preferably has an aperture or channel. The spinal implant device may include anchoring holes to secure the device to the spinal skeletal structure with fasteners or alternatively can simply be held in place by and between adjacent vertebrae.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 14, 2017
    Assignee: Vivex Biomedical, Inc.
    Inventors: Alan Davenport, Tracy Scott Anderson, Jeffrey Scott Radcliffe
  • Patent number: 9757212
    Abstract: A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises the act of immersing the microscale roughened surface into a solution containing hydrogen peroxide and a basic solution to produce a nanoscale roughened surface consisting of nanopitting superimposed on the microscale roughened surface. The nanoscale roughened surface has a property that promotes osseointegration.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 12, 2017
    Assignee: Biomet 3I, LLC
    Inventors: Robert L Mayfield, Ross W Towse
  • Patent number: 9545310
    Abstract: An implant having at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: January 17, 2017
    Assignee: NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
    Inventors: Suzanne A. Maher, Tony Chen, Joseph D. Lipman, Peter Torzilli, Russell Warren
  • Patent number: 9480773
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney
  • Patent number: 9393348
    Abstract: An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapor deposition.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: July 19, 2016
    Assignee: IHI Ionbond AG
    Inventors: Maria Pettersson, Håkan Engqvist, Johanna Olofsson, Lars Hultman
  • Patent number: 9370404
    Abstract: Provided are methods of improving the wear resistance and aesthetic properties of dental articles though use of spherical microparticles, as well as dental articles having an abrasion resistant spherical microparticle/polymer coating thereon.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 21, 2016
    Inventors: Bhaskar V. Velamakanni, Todd D. Jones, Anupa N. Patel
  • Patent number: 9339476
    Abstract: Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 17, 2016
    Assignee: Arch Biosurgery, Inc.
    Inventors: Terrence Norchi, Steven Kates, Rutledge Ellis-Behnke
  • Patent number: 9333093
    Abstract: An interbody fusion cage comprised of two support elements that separate after insertion into the interbody space to form a pocket into which graft material may be inserted. The expansion of the support elements deploys ribbons between the two support elements to further insulate the pocket into which the graft material is inserted, thereby holding it securely in place. Ribbons may be formed of a flexible material so that graft material can be inserted by a surgeon above or below them. Ribbons may also be deployed manually by the surgeon so as to allow insertion of graft material before the ribbon is deployed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 10, 2016
    Inventor: Kamran Aflatoon
  • Patent number: 9321101
    Abstract: Methods for manufacturing a metal foam and a metal foam reinforced back plate may be used to provide high-strength and low weight structural elements in portable information handling systems. A method for manufacturing a metal foam may include selectively adding iridium oxide and ceramic particulate to a light-metal allow to create desired mechanical properties of the metal foam.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: April 26, 2016
    Assignee: Dell Products L.P.
    Inventor: Deeder Mohammad Aurongzeb
  • Patent number: 9078952
    Abstract: Bone graft materials include a bone-grafting material, which encourages regeneration of a missing bone tissue while being absorbed by the missing bone tissue, and a coating material, which is composed of at least one selected from the group consisting of magnesium, calcium hydroxyapatite, and mixtures thereof.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: July 14, 2015
    Inventor: Ki-Deog Park
  • Patent number: 9050389
    Abstract: A medical implant comprises a biodegradable magnesium-based alloy of which at least a part of its surface layer comprises a magnesium carbonate. A method for the manufacture of a biocompatible, corrosion-inhibiting protective surface layer on a medical implant comprising a magnesium-based alloy, comprises: providing an implant comprising a magnesium-based alloy to be coated; placing the implant into a reactor chamber; exposing at least part of the surface of said implant to an atmosphere comprising humid carbon dioxide to produce a coating on the surface of the implant comprising a magnesium carbonate of the formula x MgCO3.y Mg (OH)2, whereby x+y=1; removing the implant from the reactor chamber; and drying the surface of the implant.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: June 9, 2015
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Peter Kurze, Thomas Imwinkelried, Stefan Beck, Dora Banerjee, Tamara Schwarz
  • Patent number: 9038564
    Abstract: A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3).
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: May 26, 2015
    Assignee: FIN-CERAMICA FAENZA S.P.A.
    Inventors: Mauro Fiorini, Daniele Pressato
  • Publication number: 20150132470
    Abstract: It is an object, with regard to a configuration for forming a macromolecular layer on a surface of a base material of an artificial joint component, to achieve a size reduction, to accurately control ultraviolet irradiation intensity, to form a macromolecular layer having a uniform thickness, to suppress the influence of ultraviolet light on equipment and workers, and to make the occurrence of a malfunction unlikely. A film-producing device body forms a macromolecular layer in an inner surface of a base material of an artificial joint component, by means of photograft polymerization. The film-producing device body includes a plurality of ultraviolet LED elements and a work holder. On the work holder, solution containing macromolecular monomers is in contact with the inner surface of the base material. The ultraviolet LED elements emit ultraviolet light to a wider area than an area that each of the ultraviolet LED elements individually irradiates.
    Type: Application
    Filed: March 28, 2013
    Publication date: May 14, 2015
    Applicant: KYOCERA Medical Corporation
    Inventor: Ryota Namba
  • Publication number: 20150132356
    Abstract: The invention relates to biomimetic peptide-containing compositions for use, in particular, for application and or deposition on a magnesium alloy, e.g., substrate, to at least partially coat a surface of the magnesium alloy. The invention also relates to the coated magnesium alloy which is particularly useful for tissue and bone repair and regeneration applications, such as, for constructing medical implant devices.
    Type: Application
    Filed: November 13, 2014
    Publication date: May 14, 2015
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: ELIA BENIASH, Charles S. Sfeir
  • Patent number: 9028907
    Abstract: The invention relates to a method for coating of a medical implant that can be used to apply a calcium salt to the surface of a medical implant easily and without expensive coating equipment and little expenditure of time. Accordingly, a method is provided that includes (i) providing a medical implant that includes at least one surface to be coated; (ii) providing a body that includes at least one calcium salt with a Mohs hardness of no more than 5.5 on at least one of its surfaces; and (iii) rubbing said body having the calcium salt-containing surface onto the at least one medical implant surface to be coated in order to coat said surface of the medical implant with the at least one calcium salt.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: May 12, 2015
    Assignee: Heraeus Medical GmbH
    Inventors: Sebastian Vogt, Hubert Büchner
  • Patent number: 9023419
    Abstract: A high-purity porous metal coating is formed over a substrate by thermal spraying a metal coating material over the desired portion of the substrate in an atmospheric air environment. The metal coating material may react with the atmosphere to cause impurities in the applied coating. The impurity-rich portion of the applied coating is subsequently removed to form the high-purity porous metal coating. Process steps are included that cause the impurity-rich portion of the applied coating to be a surface portion that is removable to arrive at the high-purity coating. A protective shroud may be used to limit the amount of impurity imparted to the applied coating and/or a getter material may be employed to continually bring impurities toward the surface of the coated substrate during coating.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 5, 2015
    Assignee: Hitemco Medical Application Inc.
    Inventors: Michael Meehan, Jinlong Wang, John Whalen, Edwin Garafalo, Rick Montalbano
  • Patent number: 9011965
    Abstract: The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the coating.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: April 21, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani, Laura S. Whitsitt
  • Patent number: 9005696
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: April 14, 2015
    Assignee: Exogenesis Corporation
    Inventors: Richard C. Svrluga, Laurence B. Tarrant
  • Patent number: 9005647
    Abstract: The present invention relates to a biocompatible ceramic material comprising Baghdadite (Ca3ZrSi2O9), and a method for its preparation. Preferably the Baghdadite is synthetically prepared. The present invention also relates to an implantable medical device comprising biocompatible Baghdadite, and a method for its production. The present invention further relates to a method for improving the long term stability of an implantable medical device and an implantable drug delivery device comprising Baghdadite. Further, the present invention relates to the use of comprising biocompatible Baghdadite in the regeneration or resurfacing of tissue.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: April 14, 2015
    Assignee: The University of Sydney
    Inventors: Hala Zreiqat, Chengtie Wu, Yogambha Ramaswamy
  • Patent number: 8999428
    Abstract: The invention relates to an orthopedic cushion made from a filled elastomer or softened thermoplastics and can be provided with a thin friction-reducing coating made from a non-polar, non-hydrophilic slip-increasing polymer coating namely poly(para-xylene). According to the invention, the above can be achieved by means of a method in which the polymerized polyurethane cushion is subjected to at least one pretreatment step in which volatile components are removed to such an extent as to be able to be immediately coated.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: April 7, 2015
    Assignee: Otto Bock Healthcare GmbH
    Inventor: Klaus-Peter Anhalt
  • Publication number: 20150086602
    Abstract: Methods of coating bone surfaces and coated bones comprising a coating comprising (a) a porous polysaccharide scaffold and/or a plurality of polysaccharide nanofibers; and (b) a polyelectrolyte multilayer composition, are disclosed. The methods of coating bone surfaces and the coated bones disclosed provide a biomimetic periosteum to compensate for periosteum lost in preparing bone grafts, and the coated bone grafts, including allografts, restore lost osteogenic and osteoinductive qualities and improve clinical outcomes.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 26, 2015
    Inventors: Matthew J. Kipper, Nicole P. Ehrhart, Raimundo Romero, Timothy R. Gonzales
  • Publication number: 20150086704
    Abstract: Embodiments of the present invention include a spray bonder that comprises a bonder, a carrier, and, optionally, a propellant. Embodiments also include a coating spray system that comprises the spray bonder and a coating spray that includes a coating material, a carrier, and, optionally, a propellant. The coating material can be an opaque material, glass fit, opacious dentin, or the like. Also provided are methods for using the spray bonder and/or coating spray to coating objects, such as coating dental implants to match the color of a patient's gums.
    Type: Application
    Filed: April 30, 2013
    Publication date: March 26, 2015
    Inventors: James R. Vinson, Phillip G. Pitts
  • Publication number: 20150072067
    Abstract: Method of manufacture of a piece designed to be fitted in the area of a dental prosthesis in the mouth of a patient, which comprises creating sugosities on the outer surface of the piece and applying a layer of TiN on the piece. The pieces allow the aesthetic results of the prosthetic treatment to be enhanced. It has also been shown that the manufactured pieces inhibit bacterial adhesion and are biocompatible.
    Type: Application
    Filed: October 9, 2013
    Publication date: March 12, 2015
    Inventor: Eduardo ANITUA ALDECOA
  • Publication number: 20150064339
    Abstract: A method for manufacturing an implant material includes preparing a base material for implant, removing moisture from a chamber in which the base material is placed, and introducing material gas as a carbon source and a silicon source into the chamber after the removal of the moisture to form a carbon thin film containing a C—C component in which carbon atoms are bonded, and a SiC component in which carbon and silicon atoms are bonded on a surface of the base material by ionized deposition.
    Type: Application
    Filed: November 11, 2014
    Publication date: March 5, 2015
    Inventors: Hiroki Nikawa, Seichiyou Makihira, Yuichi Mine, Yoshinori Abe, Tatsuyuki Nakatani, Keishi Okamoto, Yuki Nitta
  • Patent number: 8956683
    Abstract: The present invention relates to improvements in chemical vapor infiltration processes and devices for depositing a biocompatible material onto a porous substrate to form an orthopedic implant. The substrate may be formed of reticulated vitreous foam and coated with tantalum, niobium, tungsten, or other biocompatible materials.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: February 17, 2015
    Assignee: Zimmer, Inc.
    Inventors: Joseph R. Vargas, Steven J. Seelman, David B. Roberts
  • Patent number: 8951597
    Abstract: The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: February 10, 2015
    Assignee: New York University
    Inventors: Yu Zhang, Jae-Won Kim, Van P. Thompson
  • Publication number: 20150038899
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.
    Type: Application
    Filed: August 22, 2012
    Publication date: February 5, 2015
    Inventors: Laurence B. Tarrant, Richard C. Svrluga, Sean R. Kirkpatrick
  • Publication number: 20150031772
    Abstract: A coating comprised of a polymeric material and a bioactive agent where the properties of the casting solvent dictate the dispersion of the embedding bioactive agent. In preferred embodiments, controlled release of the bioactive agent is achieved by homogeneous dispersion of the bioactive agent within the coating. A further aspect of the invention is directed to formulations where the heterogeneous dispersion of the bioactive agent provides an initial rapid release of the bioactive agent. Methodology for production of coating formulations of the desired properties and the application of the coating to an article are also described.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 29, 2015
    Inventors: Mark Schallenberger, Ben Luchsinger, Todd Meyer, Helena Lovick
  • Patent number: 8940320
    Abstract: The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: January 27, 2015
    Assignee: Thommen Medical AG
    Inventors: Falko Schlottig, Matthias Schnabelrauch, Armin Rex Kautz
  • Patent number: 8932663
    Abstract: Methods for forming bone implants for the repair of the ends of bones at orthopedic joints, which implants have a Young's modulus close to that of human cortical bone. Substrates of dense isotropic graphite are coated overall with hard, microporous, isotropic pyrocarbon of specific character such that it can be polished to serve as an articular surface and can also securely receive an anchoring first metal layer through PVD. The first layer has a character such that, by thermal spraying a second biocompatible metal layer thereupon, fusion occurs and thereby anchors an outermost layer that is formed with a network of randomly interconnected pores and a surface character of peaks and valleys designed to promote enhanced appositional growth of cortical bone at the interface therewith.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: January 13, 2015
    Assignee: Ascension Orthopedics, Inc.
    Inventors: Joseph P. Ritz, Clive Scott
  • Publication number: 20150010607
    Abstract: The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 8, 2015
    Inventors: Michael Francis, Roy Ogle
  • Publication number: 20150005887
    Abstract: A joint prosthesis including a first component having a cleaned silicon carbide layer, and an annealed graphs layer disposed on the cleaned silicon carbide layer, the annealed graphene layer being a contact layer interfacing a second component of the joint prosthesis, wherein at least one of the first component and the second component is moveable with respect to the other component
    Type: Application
    Filed: June 30, 2013
    Publication date: January 1, 2015
    Inventors: CHRISTOS D. DIMITRAKOPOULOS, JAMES J. WYNNE
  • Publication number: 20150005392
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.
    Type: Application
    Filed: January 31, 2013
    Publication date: January 1, 2015
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel
  • Publication number: 20150004209
    Abstract: A metal matrix has a biocompatible solid lubricant in at least a portion of its surface and the solid lubricant functions to protect the interior of the metal matrix and minimize the friction coefficient and related wear induced damage at the articulating surface of the metal device. The lubricated biocompatible metal device is made of materials compatible for in vivo and ex vivo applications in order to minimize wear induced degradation as well as metal ion release. The lubricated biocompatible metal device is suited for use as medical implants.
    Type: Application
    Filed: February 11, 2013
    Publication date: January 1, 2015
    Applicant: WASHINGTON STATE UNIVERSITY
    Inventors: Susmita Bose, Amit Bandyopadhyay
  • Patent number: 8920869
    Abstract: This invention provides an Osseo-inductive metal implant for a living body and the producing method thereof and, more particularly, the Osseo-inductive metal implant for a living body according to the present invention is produced by forming, on the surface of the metal implant, the layer of metal oxide and the layer of bio-active material injected.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: December 30, 2014
    Assignee: Korea Institute of Machinery and Materials
    Inventors: Eung-Sun Byon, Yong-Soo Jeong, Jong-Kuk Kim, Young-Taeg Sul, Beom-Seok Chang, Lee-Ra Cho
  • Patent number: 8920868
    Abstract: A process for preparing a ceramic body having a surface roughness, said process comprising the step of depositing particles of a ceramic material on the surface of a ceramic basic body. The process is characterized in that separate agglomerates comprising at least two particles and a binder binding the particles together are deposited on the surface of the basic body by projecting the agglomerates towards the basic body.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: December 30, 2014
    Assignee: Straumann Holding AG
    Inventor: Marc Stephan
  • Patent number: 8916228
    Abstract: Biomedical scaffolds are described that may be used, for example, for the treatment of bone diseases and bone reconstruction and restoration. The described scaffolds having ingress and habitiaion property for cells and growth factors with serum by capillary action via engineered micro-channles. Also, the scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Kits that include such scaffolds and methods of preparing and using such scaffolds are also provided.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: December 23, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel Sunho Oh, Anson Ong
  • Publication number: 20140370461
    Abstract: A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Jacqueline K. Marks, Robert L. Mayfield, Ross W. Towse
  • Publication number: 20140370464
    Abstract: A process for preparing a prosthetic element comprising a glass-ceramic body. including the steps of a) providing a basic body comprising an amorphous glass phase and containing the components of the glass-ceramic body to be prepared, and b) transferring energy to the basic body to induce conversion of a starting phase of the material of the basic body into at least one crystalline phase in a confined region. According to the invention, energy is transferred to the confined region of the basic body by laser irradiating said region with a laser beam having a wavelength of at least 500 nm.
    Type: Application
    Filed: January 21, 2013
    Publication date: December 18, 2014
    Inventors: Alain Kounga, Christoph Appert, Iwona Dziadowiec
  • Publication number: 20140363392
    Abstract: The present invention relates to an osteoinductive coating for use in dental implants, which can be obtained using a sol-gel process from methyltrimethoxysilane (MTMOS) as a silicon base precursor, ethyl tetraorthosilicate (TEOS) as a hydrophilic silicon precursor and at least one silicon precursor selected from glycidoxypropyltrimethoxysilane and aminopropyltrimethoxysilane. The invention also relates to the method for obtaining said coating and to the use thereof in dental implants.
    Type: Application
    Filed: January 25, 2013
    Publication date: December 11, 2014
    Inventors: Julio Jose Suay Anton, Miriam Hernandez Escolano, Isabel Goni Echave, Maria Dolores Gurruchaga Torrecilla
  • Publication number: 20140356797
    Abstract: The purpose of the present invention is to provide a dental implant which enables the formation of a functional periodontal tissue around the implant after the implantation of the implant. The dental implant according to the present invention is characterized in that a cell mass originated from a tooth germ tissue or a periodontal ligament tissue is placed on the surface of the implant and the surface of the implant on which the cell mass is to be placed is the whole or a part of a surface that is surrounded by an alveolar bone of a recipient during the implantation of the implant.
    Type: Application
    Filed: January 28, 2013
    Publication date: December 4, 2014
    Applicant: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Masamitsu Oshima
  • Publication number: 20140356814
    Abstract: The present invention relates to a dental implant having an enhanced early stability and a method for manufacturing same, and more specifically to a dental implant and a method for manufacturing same which assure early stability and fixation power of an implant by suppressing early osteolysis after an implant procedure, and allowing better bone coherence of the implant surface during an osteogenic period by controlling the speed of bone remodeling.
    Type: Application
    Filed: October 4, 2012
    Publication date: December 4, 2014
    Inventors: Su Kyoung Kim, Eun Jung Kang, Ju Dong Song, Tae Gwan Eom, Kyoo Ok Choi
  • Publication number: 20140350331
    Abstract: The present invention relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention, and to the use of a multi-layered material as a chondral support matrix, a meniscus support matrix or an intervertebral disc support matrix.
    Type: Application
    Filed: December 10, 2012
    Publication date: November 27, 2014
    Inventors: Kai Stuckensen, Uwe Gbureck, Juergen Groll
  • Publication number: 20140343687
    Abstract: An implant includes a microstructured hyperhydrophilic surface with protrusions and depressions in which a spacing between the protrusions as a statistical mean is in a range of 1 to 100 ?m and a profile height of the protrusions and depressions as a statistical mean is in the range of 1 to 80 ?m.
    Type: Application
    Filed: December 16, 2012
    Publication date: November 20, 2014
    Inventor: Herbert Jennissen