Abstract: A method of applying a coating material to two surfaces of a plate includes the steps of applying the coating material to the two surfaces simultaneously such that holding areas in the absence of the coating material are provided on the two surfaces in proximity of side ends of the plate with respect to a travel direction of the plate, and conveying the plate by holding the holding areas.

Abstract: A catheter has an electrically conductive material coated, deposited, or otherwise formed directly on the outer surface of the catheter. Preferably, an outer electrode is formed by ion-beam assisted deposition using a preselected metal for efficient vaporization onto the designated surface region of the catheter body. Alternatively, the electrically conductive coating may be formed by sputtering the metal onto that region of the catheter, vacuum deposition, spraying, or printing the electrically conductive material onto the entire surface region. Portions of the coating may be removed by directing a laser beam onto the outer surface of the catheter and ablating such portions.

Abstract: The process and apparatus of the present invention teaches how to treat a well-integrated woven or non-woven web of hydrophobic fibers to make selective areas hydrophyllic. It also can be used to make a web of hydrophyllic fibers selectively hydrophobic. It uses a plurality of selectively adjustable covers on an applicator roll rotating in a bath of liquid to place the liquid material on selective areas of the moving web. In a preferred embodiment the web is non-woven and the fibers are hydrophobic in nature, e.g., dry-laid or melt-blown polypropylene or polyethylene fibers or spun-bonded hydrophobic filaments. A woven web made of cotton or other hydrophyllic fibers may also be used if the end result is to create partially hydrophobic areas on a hydrophyllic web. The areas of liquid are positioned on the web only where desired so as to eliminate the excessive cost of unwanted and unnecessary coating material. If the web is hydrophobic, the liquid makes that area hydrophyllic.

Abstract: A method and apparatus for applying pressure sensitive adhesive to a substrate, in which the adhesive is deposited on a transfer surface, such as a circulating transfer belt, dried, and subsequently transferred to a plurality of overlapping sheets. The sheets are preferably coated with a primer or a low adhesion backsize, or both, prior to application of the adhesive.

Abstract: Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising:(1) Forming a solution containing Linker Lipid A, the disulfide of mercaptoacetic acid (MAAD) or similar molecule, linker Gramicidin B, membrane spanning lipid C (MSL-C) and membrane spanning lipid D (MSL-D) or other suitable linker molecules and other ion channel combinations;(2) Contacting an electrode containing a clean gold surface with the solution, the disulfide containing components in the solution thus adsorbing onto the gold surface of the electrode;(3) Rinsing the electrode with a suitable organic solvent; and(4) Removing the excess organic solvent used for rinsing.

Abstract: Process for the simultaneous treatment of the top and bottom sides of a web of paper support each with a liquid coating material, whereina) the web of paper support is passed through the gap between two rubber rollers rotating in the same direction,b) the top side of the web of paper support is treated with the first coating material by means of a first rubber roller,the first coating material is transferred to the first rubber roller by a first screen roller rotating in the opposite direction,the first coating material is applied to the first screen roller by means of a pouring device,c) the bottom side of the web of paper support is treated with the second coating material by means of a second rubber roller,the second coating material is transferred to the second rubber roller by a second screen roller rotating in the opposite direction,the second coating material is applied to the second screen roller by means of a pouring device.

Abstract: An biologically compatible coating, enables an apparatus to which it is applied to resist to cell adhesion and/or protein adsorption. The coating comprises a polyacrylamide network grafted to a surface of the apparatus at polymerization sites on that surface and a poly(ethylene glycol) network interpenetrating the polyacrylamide network, and is prepared by sequentially polymerizing the polyacrylamide and poly(ethylene glycol) layers.

Abstract: An apparatus for applying a coating to an object includes a pair of reciprocating members which each include a porous resilient pad mounted for movement toward and away from each other. The apparatus includes a coating supply system for supplying coating to the resilient pads. The pads have a movement sequence from an initial rest position where the pads are spaced apart from one another to a coating loading position where the pads are in physical contact and have a degree of compression with each other to load the coating onto the pads, then the pads are moved to an intermediate rest position with the pads spaced apart an the object to be coated is moved between the pads. The sequence then includes a coating delivery position where the pads are in physical contact with each other and the object so that the pads have a degree of compression with each other and the object thereby applying the coating to the object.

Abstract: A process for coating printed circuit boards with a coating composition that is crosslinkable by electromagnetic radiation, especially UV radiation, using the roll coating process, is distinguished by the following process steps:a photopolymerisable, meltable, low-molecular-weight coating composition that is highly viscous to solid at room temperature and has an average molecular weight of preferably from 500 to 1500 is melted and fed to the applicator roll of a roll coating apparatus;the coating composition is coated at a temperature of approximately from 60.degree. to 110.degree. C. and a viscosity of approximately from 1000 to 20000 mPas on to the surface(s) of a printed circuit board in a thickness of approximately from 10 to 200 .mu.m,the surface of the printed circuit board to be coated being pre-heated, prior to coating, to a temperature that is approximately from 10.degree. to 50.degree. C. higher than the application temperature of the coating composition.

Abstract: A patterned multiple antibody substrate for use in biosensors or immunosensors is produced by (1) coating an antibody-adsorbent substrate with a material that resists antibody adsorption, (2) using ion beam sputtering, laser ablation, or mechanical scribing to remove the coating at specific sites on the substrate, and then (3) adsorbing specific antibodies at the sites. The substrate is capable of detecting multiple chemical species simultaneously.

Abstract: Laboratory vessels are coated on an operational surface thereof with a hydrophobic coating polymer or reactive monomer to form a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups. Laboratory vessels coated with such coating solutions are provided having extremely low surface energies and high resistance to solvent attack. Methods of forming hydrophobic coatings on laboratory vessels are also provided and include methods of forming exposed coating surfaces having populations of from about 30% by area to 100% by area trifluoromethyl groups. The hydrophobic coatings may be prepared from solutions, suspensions or powdered materials containing a fluoroalkyl ethylenically unsaturated monomer substantially free of any crosslinking, having from about 3 to about 20 carbon atoms, and containing at least one terminal trifluoromethyl group, or containing a polymerization product of such a monomer.

Abstract: The cytogenetic chamber includes a chamber enclosure, a drying cavity in the enclosure, a door and a hand-insertion port through the door. A slide-supported, fixative-treated cell (prepared outside the chamber or in situ in the chamber) is in the drying area and air flows through the entirety of the drying area at a substantially uniform (and relatively low) flow rate. The fixative dries at substantially the same drying rate, irrespective of the location of the slide in the drying area. A related method is also disclosed. The invention is particularly useful for chromosome spreading and results in a significantly-increased percentage of metaphases having metaphase areas in the optimal range of 2,500 to 4,500 squared microns.

Abstract: Sheets to be coated with water-based coating material, for example a primer and a low adhesion backsize, are supplied from a feeder (1), in end-to-end overlapping relationship, to a dual coater (3) in which the sheets are coated individually on both sides. A sheet inserter (2) is provided, upstream of the dual coater, to insert sheets from a second supply into the sheets from the feeder (1). The dual coated sheets are dried as individual sheets or as a pseudo-web of overlapped sheets. The sheets are then overlapped, unless previously overlapped, and the direction of overlap changed, if necessary, to provide the trailing edge of each sheet on top of the leading edge of each succeeding sheet. The overlapped sheets are conveyed through an adhesive transfer station (7) where stripes (236) of at least partially dried adhesive are coated onto the dual coated sheets from a transfer belt (71).

Abstract: Sheets to be coated with water-based coating material, for example a primer and a low adhesion backsize, are supplied from a feeder (1), in end-to-end overlapping relationship, to a dual coater (3) in which the sheets are coated individually on both sides. A sheet inserter (2) is provided, upstream of the dual coater, to insert sheets from a second supply into the sheets from the feeder (1). The dual coated sheets are dried as individual sheets or as a pseudo-web of overlapped sheets. The sheets are then overlapped, unless previously overlapped, and the direction of overlap changed, if necessary, to provide the trailing edge of each sheet on top of the leading edge of each succeeding sheet. The overlapped sheets are conveyed through an adhesive transfer station (7) where stripes (236) of at least partially dried adhesive are coated onto the dual coated sheets from a transfer belt (71).

Abstract: A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying degrees of resorption of the calcium phosphate entities in evaluating the functional properties. The film is sufficiently thin that resorption of the entities can be detected. Such film, as applied to a support, is a very useful analytical component for evaluating such bone cell functional characteristics. An analytical device, which may be used in an analytical kit, can be provided having a plurality of wells with the devices located at the bottom thereof. A process is provided for making the film and especially the film which has a combination of calcium hydroxyapatite with tricalcium phosphate.

Abstract: The new membrane biosensors consist of a solid A as a support, a lipid bilayer B as a membrane, spacers C incorporated between A and B and a receptor D embedded in the lipid bilayer. The new membrane biosensors are characterized in particular by their spacer C, which consists of a molecule of ethanolamine which forms an ester bond to the phosphatide group of the lipid bilayer B, an oligopeptide in helical or pleated sheet structure formed from 4-20 C.sub.2 -C.sub.10 -.alpha.-amino acids and a reactive group which enters into a chemical or physicochemical bond with the support A.

Abstract: Surfaced-enhanced, analytical procedures wherein a surfaced article includes a substrate surface, metal islands, a spacing/coupling agent layer, and binding partner molecules which bond with work piece molecules to be detected. A population of spaced apart metal islands are formed on the substrate and have at least some interconnections formed between them. A continuous layer coats the islands and all surfaces between the islands. The continuous layer includes a coupling agent which immobilizes first binding partner molecules. The first partner molecules bond to the coupling agent and the second binding partner molecules bind to the first binding partner molecules to allow detection of presence or concentration of the work piece binding partner molecules.

Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.

Abstract: A method and system for repairing and restoring chipped and scratched regions of an automotive body, the damage being characterized by recesses in the exterior, involves the use of color-matched paint repair material, and includes the steps of cleaning the recesses, coating the recesses and adjacent area with a lubricating agent that also will retard the ability of the repair material to bond with surfaces of the damaged region. The paint-repair material is deposited on undamaged surfaces adjacent the recesses, and then a blade comprised of a soft resilient plastic material is slidably moved over the damaged region to spread and move the deposited paint over the damaged region causing the paint-material to be deposited in the recesses and to remove most of the excess material from the undamaged surfaces adjacent to the recesses. After a short drying interval, final steps include wiping away excess repair material soft cloth wetted with a suitable solvent.

Abstract: A self-staining microscopic slide designed for immediate staining and viewing of cells in biological fluid and tissue samples, preferably with an epi-fluorescence microscope. The pre-prepared microscope slide preferably has a supravital fluorescent stain applied thereon, which is overlaid with a transparent tape or film. During use, the film is peeled back to expose the stain so that a sample can be applied thereon for intermixture therewith. The film is then replaced over the stained sample to act as a cover slip for immediate viewing. Living cells and microorganisms are rendered dramatically visible and cellular dysmorphology can be readily ascertained. The time and cost associated with preparing a fixed and sectioned sample is completely avoided as well as the problem of artifacts and sample fragmentation found in fixed preparations. The slide can include reference standards to facilitate microscope focusing, and to allow measurements of cells and microorganisms.

Abstract: An improved method and apparatus for making blood smears on microscope slides are disclosed. The method is characterized by the step of temporarily deforming the normally planar surface of a slide on which the smear is being made, rendering it slightly concave in shape. This step has been found to substantially reduce streaking and other artifacts which interfere with the formation of an uninterrupted, substantially uniform monolayer of blood cells on the slide. Preferably, the movement of a blood-smearing member across the slide is controlled as a function of various predetermined physical parameters of the blood.

Abstract: The method of forming a multilayer printed circuit board includes applying a photopolymerizable coating append having a solid content of 70 to 95% by weight and a viscosity of 10 to 60 Pa.s of 25.degree. C. to a surface of the applicator cooled to a temperature of 5.degree. C. by a metering roll surface of which is controllably maintained at a temperature range from 25.degree. to 60.degree. C., so that the coating agent is deposited on opposite sides of a board and has an application viscosity of 20 to 100 Pa.s at a coating speed of 5 to 20 m/min to form a film thickening of 10 to 200 .mu.m.

Abstract: A material consisting of a hydrophobic material having a metallic, ceramic or glass surface which has been modified by exposing the surface to a glow discharge plasma to activate the surface, followed by exposing the activated surface to one or more ethylenically unsaturated monomers and irradiating the surface with gamma or electron beam radiation to induce polymerization thereon of the monomer(s) so as to form a hydrophilic polymeric coating on the surface of an article.

Abstract: For the removal of a small amount of fluid, in particular blood, from a sealed container, and the deposition of a drop of fluid on a slide by a dropper, and the subsequent spreading of the drop, the rear end of a dropper needle having a longitudinal channel which passes therethrough is pressed through a seal into a container. Once the needle is inserted into the container, a drop of fluid moves out of the container via the longitudinal channel to a slide. After depositing the drop of fluid on the slide, the dropper itself is used to spread and distribute the drop of fluid on the slide, so that spreading of the drop of fluid is facilitated and hazardous waste is reduced to a minimum. The dropper used for this purpose is made integral with a spreader.

Abstract: Disclosed is an electrode manufacturing method for rechargeable batteries which includes the process of coating a binder on positive and negative electrodes of a rechargeable battery, wherein the process of coating is realized by passing positive and negative electrodes through rollers, mounted facing each other and which receive a supply of aqueous binder for application.

Abstract: The invention concerns a method for two-sided coating of a printing-paper web with a coating paste or equivalent. In the method, the paper web is passed through the coating part of the paper machine, in which the first side of the web is coated in the first coating station of said coating part, and the coating-agent layer produced on the face of the web is dried at least partly by means of a first drying unit. The second side of the web is coated in the second coating station of the coating part, and the second coating-agent layer produced on the face of the web is dried at least partly by means of a second drying unit.

Abstract: A method for at least one-sided coating of a material web with an application medium is performed by a two-element applicator device having at least one applicator roll and a counter element defining a gap through which the material web is conveyed. The method includes the steps of pre-metering the application medium onto the applicator roll and transferring the application medium onto the material web in the gap. Pre-metering of the application medium to the applicator device is performed by at least one free jet.

Abstract: A method for depositing particles coated with biological substances onto the concave inner surface of a length of tubing includes the steps of preparing a uniform suspension of coated particles, introducing the particles into the tubing, placing the tubing into a generally horizontal position, removing the evaporable liquid after the particles have settled, and drying the particles. When dry, the tubing is cut into sample cartridges of appropriate length for use in a particle acceleration instrument.An apparatus for performing the method is also disclosed.

Abstract: Gelatin and aminodextran coated polymer core particles useful in immunoassays and methods of making the same are disclosed. The preparation of aminodextrans having varying amounts of amine groups is also described, as is a method of crosslinking gelatin and aminodextran without the use of a stabilizer.

Abstract: An apparatus for applying a coating to an object includes a pair of rotating members each including a porous resilient roll mounted for counter-rotatory movement. The members are mounted so that they contact each other during a segment of the movement and are out of contact with each other at other segments of the movement. The apparatus includes a coating supply system for supplying a coating to the resilient rolls. The rotatory movement of the members includes a coating loading segment where the resilient rolls are in physical contact and have a degree of compression with the coating supply system for loading the coating into the rolls. The sequential movement also includes an intermediate segment where the resilient rolls are out of contact with each other and where an object to be coated is movable into position for movement between the resilient rolls when the rolls are in a coating delivery segment.

Abstract: An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.

Abstract: A method for making a surface coated or impregnated paper or paperboard by applying an aqueous additive dispersion to the wet web between the press and drying sections of a conventional paper or paperboard making machine. The aqueous additive dispersion is pre-metered onto a transfer roll and is applied to the wet web at a pressure nip between the transfer roll and a back-up roll. High solids content dispersions can be applied at high web speeds without tearing the web. The use of a high solids content aqueous dispersion having a solids content substantially equal to the solids content of the wet web at the point of application permits the method to be performed without increasing the drying load and therefore at an unreduced speed.

Abstract: A method and apparatus is disclosed for the in-line pre-impregnation of glass or synthetic fibers with a non-aqueous chemical treatment. The apparatus includes a first applicator for applying a curable, non-aqueous chemical treatment agent and a second applicator for applying a curing agent for the chemical treatment agent. The fibers are passed over the first and second applicators which are arranged either in parallel or in series, and are then joined by a gathering device to initiate curing of the chemical treatment agent on the fibers. In an alternative embodiment, the apparatus comprises a spray gun in which a mixture of the non-aqueous chemical treatment agent and curing agent are sprayed onto an applicator roll in contact with the fibers.

Abstract: A backing sheet (101) is provided with a pattern of pathways (131,132,133) of (e.g.) silica or cellulose by a printing process (e.g., screen printing). There may be multiple pathways leading from an eluant application region (117) to a detection zone (116) and thence to a waste reservoir (118). Different pathways may have different fluid traversal times because they differ in length and/or material (e.g., nitrocellulose for slow traversal and fibrous cellulose for rapid traversal by an aqueous liquid). Thus analyte and reagents deposited at depots (112,113) on different pathways are sequentially delivered to the detection zone. Reagents may be applied by printing. The detection zone may have an electrode assembly (105), also applied by printing, for detecting the effects of analyte.

Abstract: Particles coated with biological substances are deposited onto the concave inner surface of a length of tubing by a process which includes preparing a uniform suspension of coated particles and introducing the particles into the tubing while rotating horizontally. Then the speed of rotation is increased to drive the particles out of suspension and against the inner surface. After particle separation, the rotational speed is decreased and a gas is passed through the tubing to blow out the separated liquid. Next both the speed of rotation and the gas flow rate are increased to dry the particles that have been deposited against the inner surface of the tubing. An apparatus for performing the method also is disclosed.

Abstract: A resin-sealed semiconductor device includes a plurality of electronic components mounted on a printed wiring board, a circuit mounting surface of the board being resin-sealed, with connection terminals of the electronic components electrically connected to a printed wiring on the board. A surface portion of the board is coated with insulator material which contains tiny hollow spheres and constitutes a thermal expansion resin.

Abstract: A coating system for material webs, specifically of paper or cardboard, includes two mutually parallel rolls directly coordinated with each other, the rolls having a mutually variable spacing such that the rolls can be positioned to create a press gap for coating the web, or so as not to create a press gap. When the rolls are not positioned to form a press gap, the web passes over both roll shells while circumventing the applicators which have already dosed the roll shells with a coating mixture. The web passes over both roll shells for purposes of transferring the coating mixture predosed by the applicators. Solely the web pull in conjunction with the wrap angle of the two roll shells serves the final dosing by scraping off an excess quantity from the roll shells.

Abstract: The invention relates to a coating device for the coating of a size-press roll, paper or board or an equivalent moving base. The coating device includes a revolving coating bar which rests against a moving base. The coating bar extends across the machine width and is supported on a cradle substantially over its entire length. The coating bar spreads and smooths a coating agent introduced into the coating device and applied onto the moving base before the moving base contacts the coating bar. The coating bar in accordance with the invention is a smooth bar of large diameter, fitted against the moving base so that the profile of coating quantity of the coating agent can be controlled.

Abstract: Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.

Abstract: Method for the incubation of specimens (7) in fluids (5) for subsequent embedding in capsules by polymerization, the specimens (7) being put into hole capsules (2') which are open at the top and, in the lower third of their cylindrical wall, have at least a circle of passage orifices (6) which are smaller than the diameter of the specimens (7). These specimens (7) are incubated in a fluid (5) extending above these passage orifices (6). The hole capsules (2') are then introduced into enveloping capsules (3) of a larger diameter and with a likewise preferably cylindrical wall, a fluid (5) (a polymerizable monomer batch) present in the enveloping capsules (3) filling at least the gap (S) between the hole capsule (2') and the enveloping capsule (3), and this fluid (5) being finally polymerized under UV radiation or action of heat. The hole capsules (2') and the enveloping capsules (3) can be successively slipped over rams (4') which are located on a carrier (1).

Abstract: An automated biological specimen screener reports an assessment of slide and specimen preparation and quality. The automated biological specimen screener measures, parameters which reflect slide physical characteristics, specimen collection quality, and specimen preparation quality. The automated system reports an objective measure and uses a consistent standard of evaluation. The automated system evaluates characteristics of a slide set from a clinic. The automated system makes a determination of whether these characteristics are within a training capability of a given automated biological screener. Additionally, rather than periodic reviews, slides successfully scanned by the automated system may be used as part of a specimen preparation assessment.

Abstract: A soft tissue product is disclosed having uniformly distributed surface deposits of a solidified composition having a melting point of from about 30.degree. C. to about 70.degree. C. The solidified composition is applied to the outer surfaces of the tissue product in melted form, preferably by rotogravure printing. The solidified composition contains an oil, a wax, and preferably a fatty alcohol.

Abstract: A blood analyzer system is provided with improved slide making capability by coupling a blood analyzer apparatus to an automatic slidemaking apparatus by means of a clinically effective blood specimen transport assembly, which includes a blood conduit forming a curvilinear flow path that imparts a substantial angular velocity component to blood moving therein. The system enables a blood analyzer portion and a smear slide portion of a given sample to be aspirated with physical and temporal proximity.

Abstract: A method and apparatus for increasing the deposition of ions onto a surface, such as the adsorption of uranium ions on the detecting surface of a radionuclide detector. The method includes the step of exposing the surface to a complexing agent, such as a phosphate ion solution, which has an affinity for the dissolved species to be deposited on the surface. This provides, for example, enhanced sensitivity of the radionuclide detector.

Abstract: An improved method and apparatus for making blood smears on microscope slides are disclosed. The method is characterized by the step of temporarily deforming the normally planar surface of a slide on which the smear is being made, rendering it slightly concave in shape. This step has been found to substantially reduce streaking and other artifacts which interfere with the formation of an uninterrupted, substantially uniform monolayer of blood cells on the slide. Preferably, the movement of a blood-smearing member across the slide is controlled as a function of various predetermined physical parameters of the blood.

Abstract: The present invention is a sample preparation system and method that can be used with all types of analyte materials, that produces homogeneously deposited crystals across a sample surface, and that lends itself to automation. In this system and method, analyte crystallization is caused by lyophilization. A homogeneous analyte/solvent mixture is placed on a sample surface. The mixture is frozen, then the solvent is sublimated through the application of a vacuum. A homogenous distribution of analyte crystals across the sample surface results.

Abstract: New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention concerns the formation of a manganese ion and enzyme-antibody conjugate in aqueous solution and drying the solution to produce a dry stabilized enzyme-antibody conjugate. Further, this stabilized enzyme-antibody conjugate can be formed on a continuous web and dried in a heat tunnel. This continuous manufacturing process allows for the more efficient production of multi-layer test strips.

Abstract: An aqueous colloidal dispersion for diagnostic or immunodiagnostic tests, comprising non-polymer nuclei surrounded by a hydrophilic copolymer that contains functional groups, a method for the detection of a specifically binding substance or immunochemically active component in a test fluid, and test kit containing the aqueous colloidal dispersion.

Abstract: A holder for a slide comprising: a base, sized to accommodate the slide on a portion of its area and having an integrated hinge that permits the base to fold over itself and thereby cover the slide; at least three retaining clips affixed to the base and positioned to contact the slide and hold the slide against the base, the at least three retaining clips sized to maintain the portion of the base that covers the slide at a uniform distance from the slide; a tab formed as part of the base and positioned adjacent to the at least three retaining clips; and a clasp positioned on the base to keep the base folded over itself.

Abstract: A method for forming an optical device for detecting the presence or amount of an analyte of interest comprising a substrate which supports an optically active layer, an attachment layer provided on the optically active layer, and a receptive layer specific the analyte provided on the attachment layer. The method comprises forming the optically active layer with a chosen refractive index on the substrate by curing the optically active layer on the substrate at a controlled temperature or for a controlled length of time and subsequently providing the attachment and receptive layers on the optically active layer.