Using Fungi Patents (Class 435/171)
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Patent number: 8304219Abstract: This invention relates to the use of microorganisms for the generation of ethanol from lignocellulosic waste materials. Yeast strains of the genus Kluyveromyces which have the capability to ferment cellulose, hexose sugars to ethanol are provided. Also provided are methods for converting cellulose, hexoses, or mixed hydrolysates of hexoses to ethanol by fermentation with Kluyveromyces strains. The invention also provides methods to isolate yeast strains which metabolize cellulose, pentoses, or hemicelluloses from waste materials.Type: GrantFiled: February 1, 2008Date of Patent: November 6, 2012Assignee: Phage Pharmaceuticals, Inc.Inventor: Robert Paul Levine
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Patent number: 8303701Abstract: A novel modified thermoplastic starch is manufactured from a native starch using a polysaccharide produced by the fungus species Ophiostoma ulmi, by growing a culture in a yeast extract medium; adding the native starch; mixing, and harvesting the modified thermoplastic starch. The modified thermoplastic starch may be used in the manufacture of a biodegradable plastic which exhibits low water absorbency and high tensile strength. The plastic may be used to manufacture films or molding products by casting, extrusion, injection, or compression techniques.Type: GrantFiled: April 6, 2011Date of Patent: November 6, 2012Inventors: Mohini Sain, Robert Jeng
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Publication number: 20120276567Abstract: The invention relates to a Talaromyces transformant comprising one or more recombinant gene, capable of producing cellulase in the absence of cellulase inducer in a glucose medium, having a cellulase activity of 2 WSU/ml or more, in 16 times or more diluted supernatant or broth.Type: ApplicationFiled: November 4, 2010Publication date: November 1, 2012Applicant: DSM IP ASSETS B.V.Inventors: Alrik Pieter Los, Brenda Vonk, Marco Alexander Berg Van Den, Robbertus Antonius Damveld, Cornelis Maria Jacobus Sagt, Adrianus Wilhelmus Hermanus Vollebregt, Margot Elisabeth Francoise Schooneveld-Bergmans
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Publication number: 20120276585Abstract: The present invention relates to a method for producing a hydrolysate of from lignocellulose-containing material, comprising pre-treatment with low temperature, hydrolysis and fermentation, wherein hydrolysis is performed by contacting the lignocellulose-containing material with an enzyme composition comprising at least 10% xylanase enzyme protein w/w%.Type: ApplicationFiled: December 21, 2010Publication date: November 1, 2012Applicants: COFCO CORPORATION, NOVOZYMES A/SInventors: Haiyu Ren, Dongmin Li, Yun Wang, Chuanji Fang, Hong Zhi Huang
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Publication number: 20120270291Abstract: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.Type: ApplicationFiled: October 11, 2011Publication date: October 25, 2012Inventors: Jing Cheng, Chia-Wen Chen, Steven Francis Schnittger, Ming Lu
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Patent number: 8293508Abstract: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate. In particularly preferred embodiments, the present invention provides means for the production of ethanol.Type: GrantFiled: October 4, 2005Date of Patent: October 23, 2012Assignee: Danisco US Inc.Inventors: Oreste Lantero, Jayarama K. Shetty
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Patent number: 8288135Abstract: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids.Type: GrantFiled: October 30, 2007Date of Patent: October 16, 2012Assignee: DSM IP Assets B.V.Inventor: William R. Barclay
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Patent number: 8287971Abstract: Spalted wood veneer, which can be used in the commercial production of engineered wood flooring having a spalted wood veneer decorative layer, is produced by forming a wood veneer piece, inoculating the wood veneer piece with spalting spores, subjecting the inoculated veneer piece to a predetermined environment, then inspecting the inoculated veneer piece to determine the degree of spalting, and when a desired degree of spalting is reached, deterring continued spalting.Type: GrantFiled: September 17, 2007Date of Patent: October 16, 2012Assignee: Armstrong World Industries, Inc.Inventor: Brian W. Beakler
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Publication number: 20120244592Abstract: The invention relates to a method for obtaining mutant yeast strains having an amplified PPP, characterised in that it comprises the culture of the strains on a substrate containing a gluconic acid salt.Type: ApplicationFiled: November 18, 2010Publication date: September 27, 2012Inventors: Sylvie Dequin, Anne Ortiz-Julien, Axelle Cadiere
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Publication number: 20120237996Abstract: The composite material is comprised of a substrate of discrete particles and a network of interconnected mycelia cells bonding the discrete particles together. The mycelia cells are selected from the group consisting of at least one of Agrocybe brasiliensi, Flammulina velutipes, Hypholomoa capnoides, Hypholoma sublaterium, Morchella angusticeps, Macrolepiota procera and Coprinus comatus. The fungus digests the nutrient material over a period of time sufficient to grow hyphae and to allow the hyphae to form a network of interconnected mycelia cells through and around the discrete particles thereby bonding the discrete particles together to form a self-supporting composite material.Type: ApplicationFiled: May 29, 2012Publication date: September 20, 2012Inventors: Eben Bayer, Gavin McIntyre, Burt L. Swersey
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Patent number: 8257959Abstract: The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate of at least one generation per 48 hours using xylose as a sole carbon source for growth made by non-recombinant methods.Type: GrantFiled: June 8, 2005Date of Patent: September 4, 2012Assignee: Microbiogen Pty LtdInventors: Philip John Livingstone Bell, Paul Victor Attfield
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Publication number: 20120219993Abstract: A method for producing microbial intracellular products, and more particularly a method of producing microbial intracellular products from volatile fatty acids derived from organic waste is provided. The method of producing microbial intracellular products from volatile fatty acids in a multi-stage continuous high-cell-density culture bioreactor system includes the steps of: (a) culturing microorganisms in a bioreactor for microbial growth, thereby growing the microorganisms; (b) culturing the grown microorganisms of step (a) in a bioreactor for production of microbial intracellular products, which includes a medium containing volatile fatty acids, thereby producing microbial intracellular products; and (c) recovering the intracellular microbial products from the culture medium of the bioreactor for production of microbial intracellular products.Type: ApplicationFiled: November 17, 2011Publication date: August 30, 2012Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ho Nam CHANG, Qiang Fei, Jin Dal Rae Choi, Nag Jong Kim, Woohyun Kim
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Patent number: 8241872Abstract: A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.Type: GrantFiled: March 13, 2009Date of Patent: August 14, 2012Assignee: Astellas Pharma Inc.Inventors: Ikuko Nakamura, Koji Yoshikawa, Teruhisa Masaki, Ryuichi Kanasaki, Neelam Shahab
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Patent number: 8241881Abstract: Compositions and methods for forming hexane, and, optionally, gasoline and/or components of a gasoline composition, from fermentable sugars are disclosed. The sugars are fermented using a bacteria or yeast that predominantly forms butyric acid. The butyric acid is subjected to Kolbe or photo-Kolbe electrolysis to form hexane. The hexane can be subjected to catalytic, reforming and/or isomerization steps to form higher octane products, which are or can be included in gasoline compositions. In one aspect, the fermentable sugars are derived from lignocellulosic materials such as wood products, switchgrass, or agricultural wastes. These materials are delignified to form lignin, cellulose and hemicellulose. The cellulose and hemicellulose are depolymerized to form glycose and xylose, either or both of which can be fermented by the bacteria.Type: GrantFiled: February 14, 2007Date of Patent: August 14, 2012Assignee: CPS Biofuels, Inc.Inventor: David Bradin
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Patent number: 8241868Abstract: A method for isolating one compound or more than one compound from a biomass which contains microorganisms that have produced the compound or compounds, the method comprising the following steps: (a) preparing or obtaining wet cells having an average moisture content of between 30% and 80%; (b) subjecting the wet cells to primary drying to obtain primary dried cells having an average moisture content of between 5% and 50%; (c) subjecting the primary dried cells obtained in (b) to secondary drying to obtain secondary dried cells having an average moisture content of no greater than 10%; and (d) extracting or isolating, purifying and/or refining the compound or each of the compounds from the secondary dried cells obtained in (c).Type: GrantFiled: February 8, 2006Date of Patent: August 14, 2012Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Kenichi Higashiyama, Toshiharu Nakajima
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Patent number: 8236535Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.Type: GrantFiled: April 3, 2009Date of Patent: August 7, 2012Assignee: Xyleco, Inc.Inventors: Marshall Medoff, Thomas Craig Masterman
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Publication number: 20120190066Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.Type: ApplicationFiled: July 1, 2010Publication date: July 26, 2012Applicant: DSM IP ASSETS B.V.Inventors: Noël Nicolass Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
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Patent number: 8227221Abstract: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein increased levels of one or more pyrophosphatase enzymes are present in the fermentation medium.Type: GrantFiled: November 19, 2008Date of Patent: July 24, 2012Assignee: Novozymes North America, Inc.Inventors: Chee-Leong Soong, Jiyin Liu, Zhengfang Kang
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Patent number: 8227220Abstract: The present invention provides a process for the preparation of ethanol from starch. Specifically, the present invention provides a process for the preparation of ethanol from starch such as tapioca, potato, sweet sorghum, rice by liquification and saacharification of starch and subsequent fermentation of mono saccherides to ethanol in presence of thermophilic micro-organisms.Type: GrantFiled: March 26, 2008Date of Patent: July 24, 2012Assignee: Council of Scientific & Industrial ResearchInventors: Dilip Adhikari, Tsering Stobdan, Ravindra Pal Singh, Ashok Kumar Gupta
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Patent number: 8227218Abstract: The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.Type: GrantFiled: August 30, 2007Date of Patent: July 24, 2012Assignee: BASF SEInventors: Rainer Stürmer, Bernhard Hauer, Bettina Rosche, André Mueller
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Patent number: 8216803Abstract: The present invention provides compositions and methods for reducing H2S levels in fermented beverages.Type: GrantFiled: March 13, 2008Date of Patent: July 10, 2012Assignee: The Regents of the University of CaliforniaInventors: Linda F. Bisson, Angela Linderholm, Kevin L. Dietzel
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Publication number: 20120171719Abstract: Disclosed herein are transformed Yarrowia lipolytica comprising an exogenous polynucleotide encoding a polypeptide having sucrose invertase activity. Also disclosed are methods of using the transformed Y. lipolytica.Type: ApplicationFiled: November 15, 2011Publication date: July 5, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Seung-Pyo Hong, John E. Seip, Quinn Qun Zhu
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Patent number: 8202713Abstract: Pythium, when cultured with crude glycerol as a carbon source, produces useful polyunsaturated fatty acids such as eicosapentaenoic acid (EPA). The crude glycerol is pretreated to remove soaps and methanol. An exemplary Pythium species for use in the production of EPA is Pythium irregulare.Type: GrantFiled: May 15, 2009Date of Patent: June 19, 2012Inventors: Zhiyou Wen, Sncha Athalye
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Publication number: 20120142047Abstract: An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.Type: ApplicationFiled: November 29, 2011Publication date: June 7, 2012Applicant: Therapeutic Proteins, Inc.Inventor: Sarfaraz K. Niazi
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Publication number: 20120135475Abstract: The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.Type: ApplicationFiled: May 21, 2010Publication date: May 31, 2012Applicant: SUD-CHEMIE AGInventors: Andre Koltermann, Markus Rarbach, Thomas Bruck, Jochen Gerlach, Isabel Unterstrasser, Andreas Kohl, Zdravko Dragovic, Ulrich Kettling
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Patent number: 8187861Abstract: For extracting phosphorous from algae-in a body of water, the algae are deposited into a sealable tank (200) that is then evacuated, thereby rupturing the algal cell walls. The ruptured algae are then moved to a second tank (260), mixed with water and bacterial cultures, and allowed to settle until the lipids rise to the top and the oil-less debris settles to the bottom. The second tank also contains sacrificial (295) and rusted electrodes (320). The phosphorous from the algae combines with the rust. The lipids and debris are then removed. Next, an electrical source (315) causes the rust to be removed from the rusted electrodes and settle. In addition, a phosphorous-rich scum floats to the top. These components are placed in storage containers for later use and the water is returned, thereby reducing its phosphorous content.Type: GrantFiled: February 26, 2010Date of Patent: May 29, 2012Inventor: Allen John Schuh
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Patent number: 8187847Abstract: The present invention relates to the use of at least one inorganic nitrate in a fermentation process for producing erythritol using a yeast strain of the Moniliella species as an erythritol-producing microorganism characterized in that the at least one inorganic nitrate is simultaneously used as a main nitrogen source and as a pH regulator in the culture medium, as well as to such an improved method for producing erythritol.Type: GrantFiled: October 1, 2007Date of Patent: May 29, 2012Assignee: Jungbunzlauer Austria AGInventors: Robert Edlauer, Stefan Trimmel
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Publication number: 20120122162Abstract: This disclosure relates to a method for performing high solids saccharification comprising by (a) providing a cellulosic biomass; (b) pretreating the cellulosic biomass in a pretreatment process to produce a pretreated cellulosic biomass; (c) adjusting said pretreated cellulosic biomass to a solids concentration of 6% to 35% w/w and a starting pH of between 5-7; and (d) hydrolyzing the pretreated biomass with at least one aqueous hydrolyzing liquid comprising at least one enzyme selected from the group consisting of a cellulase, a saccharification enzyme, and a combination thereof for a period of time, to hydrolyze at least a part of the pretreated cellulosic biomass to a cellulosic hydrolysate, said cellulosic hydrolysate comprising fermentable sugars.Type: ApplicationFiled: November 14, 2011Publication date: May 17, 2012Applicant: Andritz Inc.Inventors: Rodolfo ROMERO, Bertil Stromberg
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Publication number: 20120121522Abstract: Compositions comprising metabolized conditioned growth medium and/or metabolized cell extract and methods of use are described. The metabolized conditioned growth medium and metabolized cell extract compositions may be formulated with an acceptable carrier into injectable or topical formulations, for example, as a cream, lotion or gel, and may be used in cosmeceutical or pharmaceutical applications. The metabolized conditioned growth medium and metabolized cell extract may also be further processed to concentrate or reduce one or more factors or components contained within the metabolized conditioned growth medium or metabolized cell extract. The growth medium may be conditioned by any eukaryotic cell. The metabolized conditioned growth medium and metabolized cell extract may be used to prevent or treat a condition, for example, a skin condition.Type: ApplicationFiled: November 11, 2011Publication date: May 17, 2012Applicants: Arch Personal Care Products, L.P., SkinMedica, Inc.Inventors: James Vincent Gruber, Smitha Rao, Rahul Mehta, Sujatha Sonti
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Publication number: 20120115186Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia, and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.Type: ApplicationFiled: July 6, 2010Publication date: May 10, 2012Applicant: DSM IP ASSETS B.V.Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Bianca Elisabeth Maria Gielesen, Nicolette Jasmijn Broers, Beate Wiedemann, Wilhelmus Theodorus Antonius Maria De Laat
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Patent number: 8173405Abstract: According to one embodiment, the description relates to a method of nerolidol production. The method includes culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA reductase in synthetic medium lacking uracil and producing nerolidol. The pH of the medium may be adjusted to an acidic level to further increase nerolidol production. Other chemicals may also be produced by this method. The nerolidol or other chemicals may be removed from the yeast or medium or both. The medium may additionally contain a polyaromatic resin, which may adsorb nerolidol or other chemicals.Type: GrantFiled: December 12, 2007Date of Patent: May 8, 2012Assignee: William Marsh Rice UniversityInventors: Caroline Virginia McNeil, Pietro Morlacchi, Alyssa Baevich, Seiichi Paul Tillich Matsuda
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Publication number: 20120100589Abstract: A method for treatment of a material comprising lignocellulosic fibres is disclosed. More particularly, the treatment increases the accessibility of the lignocellulosic fibres for following microbial or biological processes.Type: ApplicationFiled: March 8, 2010Publication date: April 26, 2012Applicants: XERGI A/S, NOVOZYMES A/SInventors: Danielle Rhine, Anders Peter Jensen, Stefan Borre-Gude
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Publication number: 20120100576Abstract: The present invention pertains to a system for culturing cells comprising a culturing bag and a continuous flow centrifuge wherein the cells are continuously separated from the supernatant and are recycled into the culturing bag. Further provided are methods for culturing cells and for producing a biological substance using the device for culturing cells, and the use of a bag for culturing cells in said device or said methods. In particular, a perfusion system for culturing cells is provided wherein the wave technology for culturing cells is combined with continuous flow centrifugation for separating the medium from the cells.Type: ApplicationFiled: July 8, 2010Publication date: April 26, 2012Applicant: GLYCOTOPE GMBHInventors: Steffen Goletz, Rainer Stahn, Annett Hillemann
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Publication number: 20120083023Abstract: Oleaginous yeast strains are used to hydrolyze biomass (e.g. wheat straw) that has been pretreated using dilute acid, in order to produce lipids. The lipids may be used as feedstock for producing biofuels.Type: ApplicationFiled: September 6, 2011Publication date: April 5, 2012Inventors: Xiaochen YU, Yubin ZHENG, Shulin CHEN
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Patent number: 8148113Abstract: A method for producing glucosamine with microorganism comprises of fermenting with a microorganism selected from the group consisting of Monascus pilosus and Aspergillus sp. in a novel low-cost medium, thereby enable it to produce glucosamine; wherein said medium is consisted of commercial Taiwan sugar, soy beam, rice bran and the like; wherein suitable condition for the fermentation is: 150˜300 rpm, pH 4˜pH 8, and 24° C.˜37° C.; wherein, after fermentation culturing, the fermentation liquor is filtered with suction to recover said microorganism biomass, said microorganism biomass is then subjected to steps of cell disruption, hydrochloric acid reaction, neutralization reaction and filtration, to obtain glucosamine produced by the microorganism.Type: GrantFiled: March 19, 2009Date of Patent: April 3, 2012Assignee: Yuan Ze UniversityInventors: Ho-Shing Wu, Yu-Fen Chang, Yu-Chiao Wei
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Publication number: 20120077244Abstract: A method for controlling a fermentation process includes injecting a mash into a fermenter and injecting a liquid ammonia additive into the fermenter. The liquid ammonia additive is injected in a closed-loop manner. The method may be used to control the fermentation processes of one or more fermenters operating in parallel.Type: ApplicationFiled: September 23, 2010Publication date: March 29, 2012Applicant: ROCKWELL AUTOMATION TECHNOLOGIES, INC.Inventors: Srinivas Budaraju, James F. Bartee
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Patent number: 8143020Abstract: The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor accepts electrons from the microbe after oxidation of the carbon source. Other transfers of electrons can take place to enhance the production of the metabolite, such as acids, biofuels or brewed beverages.Type: GrantFiled: April 3, 2009Date of Patent: March 27, 2012Assignee: U.S. Department of EnergyInventor: Devicharan Chidambaram
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Patent number: 8137954Abstract: Methods and materials are provided for the production of compositions of erythropoietin protein, wherein said compositions comprise a pre-selected N-linked glycosylation pattern as the predominant N-glycoform.Type: GrantFiled: May 13, 2010Date of Patent: March 20, 2012Assignee: Glycofi, Inc.Inventors: Natarajan Sethuraman, Juergen Nett, Robert Davidson
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Publication number: 20120064568Abstract: The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and, hosts engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced.Type: ApplicationFiled: March 24, 2011Publication date: March 15, 2012Applicant: Glycofi, Inc.Inventor: Stephen Hamilton
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Patent number: 8124387Abstract: The invention relates to a process for the production of optically active Citronellal by enzymatic reduction of Citral with a reductase from Zymomonas mobilis.Type: GrantFiled: November 10, 2006Date of Patent: February 28, 2012Assignee: BASF SEInventors: Rainer Stuermer, Thomas Friedrich, Andre Mueller, Bernhard Hauer, Bettina Rosche
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Publication number: 20120045803Abstract: Disclosed is a yeast strain of Candida utilis, wherein the yeast strain has been transformed with at least one of three genes that are operatively linked to a promoter sequence and encode polypeptides having activities of xylose reductase, xylitol dehydrogenase, and xylulose kinase. The yeast strain is useful for producing a metabolic product from xylose with high efficiency.Type: ApplicationFiled: February 23, 2010Publication date: February 23, 2012Inventors: Hideyuki Tamakawa, Shigehito Ikushima, Yuki Konoeda
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Patent number: 8119373Abstract: In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 420 ?m or more and which has an ability to adsorb histidine and then an eluent is passed through the column whereby accomplishing the separation and purification of histidine, and preferably in the step mentioned above, a strong acid cation exchange resin is employed as a carrier particle whereby accomplishing the separation and purification of histidine.Type: GrantFiled: March 15, 2007Date of Patent: February 21, 2012Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Hideki Murata, Noboru Fujii, Kenji Tajima
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Patent number: 8110384Abstract: A process and system for converting animal waste to useful biofuel products, and more particularly a process and system for converting excrement from lactating dairy cattle to a combination of ethanol, methane, carbon dioxide and fertilizer is presented. The system uses a continuous process to place the animal waste into an aqueous mixture with a starter sugar and a digestive microorganism into a heated anaerobic digester. The products of the reactions within the digester include methane, which is extracted in a gaseous form, and ethanol and carbon dioxide, which are separated out of an aqueous solution in a distillation column. The water from the solution is recycled and the solid residue remaining in the digester is dried in a rotary kiln and granulated to form a fertilizer material.Type: GrantFiled: December 21, 2007Date of Patent: February 7, 2012Assignee: KB Energy, LLCInventor: Robert E. Harper
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Publication number: 20120027856Abstract: A pharmaceutical product containing an active pharmaceutical ingredient and having a controllable release of the active pharmaceutical ingredient. The pharmaceutical product comprises yeast that is capable of fermentation. The carbon dioxide production of the fermentation releases the active pharmaceutical ingredient from the pharmaceutical product.Type: ApplicationFiled: August 21, 2008Publication date: February 2, 2012Applicant: LTS Lohmann Therapie-Systeme AGInventors: Bodo Asmussen, Christiane Schiller, Werner Weitschies, Grzegorz Garbacz, Mahmoud A. Omer-Adam, Stefan Nagel
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Publication number: 20120028327Abstract: Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.Type: ApplicationFiled: February 25, 2010Publication date: February 2, 2012Inventors: Mark Goebl, Cary Woods, Ross Cocklin, Josh Heyen
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Patent number: 8093019Abstract: A fermentation process using hemicellulose-derived carbohydrates for the production of cellulase mixtures with a high proportion of cellulases relative to hemicellulases is provided. The cellulases produced by the process of the invention are further characterized by high specific productivity. The resulting cellulase mixtures comprise at least two times more cellulase than hemicellulase and are useful for the hydrolysis of cellulosic substrated, particularly, pretreated lignocellulosic substrate.Type: GrantFiled: August 28, 2008Date of Patent: January 10, 2012Assignee: Iogen Energy CorporationInventors: Jason B. Edwards, Brian E. Foody, Glenn D. Munkvold
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Publication number: 20120003302Abstract: The invention concerns a high water soluble product, containing a dehydrated material, obtained by fermenting wheat germ in aqueous medium in the presence of microorganisms of the Saccharomyces genus, forming amorphous crystal structure with inert auxiliary materials), commonly used in preparation of drugs. The invention also relates to the production process of said products, to immunostimulatory, immunomodulatory, antitumor and cardiovaskular pharmaceutical preparations containing them, and to the therapeutic methods for their use.Type: ApplicationFiled: March 3, 2010Publication date: January 5, 2012Inventor: Máté Hidvégi
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Publication number: 20110318805Abstract: A process for producing flavor constituents from spent vanilla materials, comprising treating the materials with microorganisms such as bacteria, fungi and yeast, that produce enzymes having the ability to degrade the plant cells systems of the materials, and recovering the flavor constituents so produced.Type: ApplicationFiled: September 3, 2010Publication date: December 29, 2011Inventor: Ivica Labuda
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Publication number: 20110318790Abstract: The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by transformation with nucleotide sequences coding for a xylose isomerase that has one or more specific sequence elements typical for isomerases having the ability of functional expression in yeasts, such as e.g. xylose isomerases obtainable from a bacterium of the genera Clostridiumand Fusobacteriumor a tunicate form the genus Ciona. The cell preferably is a yeast or a filamentous fungus, more preferably a yeast is capable of anaerobic alcoholic fermentation.Type: ApplicationFiled: December 24, 2009Publication date: December 29, 2011Inventors: Aloysius Wilhelmus Rudolphus Hubertus Teunissen, Johannes Adrianus Maria De Bont
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Publication number: 20110306083Abstract: Methods are provided for selecting microbial strains with improved properties for fermentation and/or bioproduct production. A salt selection is employed to identify mutants with improved bioproduct tolerance, titer, or osmotic tolerance relative to a microbial strain from which they were derived.Type: ApplicationFiled: June 13, 2011Publication date: December 15, 2011Applicant: Cobalt Technologies, Inc.Inventor: Jeanette M. MUCHA