Nucleoside Patents (Class 435/87)
-
Patent number: 5547858Abstract: Crystals of an amino acid, a nucleic acid or a derivative thereof can be efficiently isolated and purified at low cost from a solution containing the crystals, bacterial cells and medium components by using a liquid cyclone.Type: GrantFiled: July 11, 1994Date of Patent: August 20, 1996Assignee: Ajinomoto Co., Inc.Inventors: Yoshimi Nagano, Takao Suganuma, Kazuhiro Satoh, Masao Ikeda
-
Patent number: 5547857Abstract: The present provides a process for obtaining high-purity 5-methyluridine crystals from nucleic acid ingredients as starting materials using a microorganism. The process comprises culturing a microorganism, removing part or the whole of the culture medium ingredients, conducting the enzyme reaction by the microorganism, crystallizing 5-methyluridine formed, and separating the obtained crystals from other impurity crystals on the basis of a difference in the precipitation rate.Type: GrantFiled: April 17, 1995Date of Patent: August 20, 1996Assignee: Ajinomoto Co., Inc.Inventors: Shogo Maruyama, Satoshi Kumon
-
Patent number: 5506122Abstract: The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby forming an N-glycosidic bond between the base moiety of the base donor and the saccharide moiety of the saccharide residue donor, which comprises using, as the enzyme preparation containing nucleoside phosphorylase, a preparation derived from the cells of one or more kinds of microorganisms belonging to thermophiles of the genus Bacillus and having high nucleoside phosphorylase activity per unit cell weight.Type: GrantFiled: October 7, 1994Date of Patent: April 9, 1996Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Hiroshi Yamauchi, Hideki Utsugi, Yuichiro Midorikawa
-
Patent number: 5468849Abstract: Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.Type: GrantFiled: March 21, 1994Date of Patent: November 21, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Kin S. Lam, Daniel R. Schroeder, Jacqueline Mattei, Salvatore Forenza, James A. Matson
-
Patent number: 5463035Abstract: A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated eluate to a strongly basic anion exchange resin charged with borate ion; 5) eluting with water; 6) applying this eluate to styrene-divinylbenzene beads prewashed with ethanol; 7) eluting the beads with water; and 8) recrysllyzing the pentostatin from water and methanol to yield a product that is greater than 99.7% pure.Type: GrantFiled: February 28, 1995Date of Patent: October 31, 1995Assignee: Warner-Lambert CompanyInventors: James C. French, Colin R. Edmunds, Peter McDonnell, Howard D. H. Showalter
-
Patent number: 5391550Abstract: Disclosed are methods and compositions of matter for increasing the intracellular synthesis of ATP. The compositions comprise amino acids, metabolites, electrolyte and/or a pentose sugar. When applied to wounds, the invention increases the rate of wound repair and has a antimicrobial effect. When administered orally, the invention increases ATP blood levels and physical performance levels.Type: GrantFiled: October 2, 1989Date of Patent: February 21, 1995Assignee: Raymond A. RoncariInventors: Francis J. Carniglia, Alan J. Kenyon
-
Patent number: 5384251Abstract: The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby forming an N-glycosidic bond between the base moiety of the base donor and the saccharide moiety of the saccharide residue donor, which comprises using, as the enzyme preparation containing nucleoside phosphorylase, a preparation derived from the cells of one or more kinds of microorganisms belonging to thermophiles of the genus Bacillus and having high nucleoside phosphorylase activity per unit cell weight.Type: GrantFiled: May 4, 1993Date of Patent: January 24, 1995Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Hiroshi Yamauchi, Hideki Utsugi, Yuichiro Midorikawa
-
Patent number: 5356772Abstract: The present invention encompasses an improved immunoassay method which involves the simultaneous transfer of multiple antigens onto a single solid support. The antigens which may be utilized by this method may be either naturally or recombinantly produced and may be purified on a variety of electrophoresis gels. This method is particularly useful to provide an extremely sensitive multiple component assay using essentially pure antigenic polypeptides capable of detecting the presence or antibodies to HIV-1 or HIV-2 viruses in infected patients.Type: GrantFiled: December 5, 1990Date of Patent: October 18, 1994Assignee: Abbott LaboratoriesInventors: Emerson W. Chan, William G. Robey, Werner Schulze
-
Patent number: 5345961Abstract: A toy cardboard tent deployable from a flat, stored configuration including two identically shaped side panels which are integrally connected along a central longitudinal fold line therebetween and a triangular shaped flat back panel. The back panel is securable as by a locking tab and slot arrangement to an upright rear end margin of each side panel. Each side panel preferably includes indicia printed thereon, identical on each side panel, which depicts an animal figure such as a dinosaur or other fanciful figure positioned on each side panel so as to be facing toward a distal upright front end margin of each side panel. Each front end margin is contoured to conform to the forwardly facing profile of the animal or fanciful figure. Peep flaps, vent holes, and a pair of window flaps are also provided.Type: GrantFiled: October 7, 1993Date of Patent: September 13, 1994Assignee: Dino Pal Toys Ltd.Inventors: N. Wayne Yercha, Desmond W. Dennis
-
Patent number: 5326754Abstract: An antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.Type: GrantFiled: May 18, 1993Date of Patent: July 5, 1994Assignee: Bristol-Myers Squibb Co.Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
-
Patent number: 5306629Abstract: A method for producing a dinucleoside polyphosphate, a nucleoside polyphosphate or a derivative thereof which comprises using adenosine-5'-triphosphate, polyphosphate or a derivative thereof and a sulfate as reaction substrates and forming a dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof via a two-stage reaction through the use of two enzymes, namely, adenosine-5'-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts.Type: GrantFiled: April 15, 1993Date of Patent: April 26, 1994Assignee: Unitika Ltd.Inventors: Hideki Yamamoto, Mika Manabe, Hiroshi Nakajima
-
Patent number: 5288606Abstract: The present invention provides a process for the specific determination of the serum fructosamine content in blood or samples derived from blood by reaction with an appropriate color reagent and measurement of the color change thereby brought about, wherein, before the color reaction, non-specific reducing-acting and/or turbidity-causing sample components are removed at approximately neutral pH value, subsequently the pH is adjusted to a value of from 10 to 12 and the color reagent is added thereto.The present invention also provides a reagent mixture for the specific determination of the serum fructosamine content in blood or samples derived from blood, wherein it comprises a reagent for the removal of non-specific reducing-acting and/or turbidity-causing sample components, a rebuffering reagent with a buffer which has a pH value in the range of from 10.5 to 12.5 and a color reagent for the detection of fructosamine.Type: GrantFiled: July 9, 1992Date of Patent: February 22, 1994Assignee: Boehringer Mannheim GmbHInventors: Joachim Siedel, Joachim Ziegenhorn, Lieselotte Schellong, Bernd Vogt
-
Patent number: 5258301Abstract: The present invention concerns a process for producing nucleosides by carrying out the reaction of a base donor, a saccharide residue donor and a phosphoric acid donor by the use of an enzyme preparation containing nucleoside phosphorylase, thereby forming an N-glycosidic bond between the base moiety of the base donor and the saccharide moiety of the saccharide residue donor, which comprises using, as the enzyme preparation containing nucleoside phosphorylase, a preparation derived from the cells of one or more kinds of microorganisms belonging to thermophiles of the genus Bacillus and having high nucleoside phosphorylase activity per unit cell weight.Type: GrantFiled: October 26, 1990Date of Patent: November 2, 1993Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Hiroshi Yamauchi, Hideki Utsugi, Yuichiro Midorikawa
-
Patent number: 5204245Abstract: An enzymatic process for extracting a nucleoside, such as thymidine, from a biomass without substantial thymine production.Type: GrantFiled: May 15, 1991Date of Patent: April 20, 1993Assignee: E. I. du Pont de Nemours and CompanyInventors: James A. Doncheck, James R. Millis, Paul E. Swanson
-
Patent number: 5169759Abstract: Riboflavin is removed from fermentation suspensions by them being heated at from 50.degree. to 90.degree. C. for from 1 to 3 hours, than cooled to from 0.degree. to 30.degree. C. over a period of from 1 to 5 hours, and subsequently being centrifuged to give a sediment fraction and liquid fraction in such a way that the sediment fraction contains predominantly riboflavin crystals as solid, and the liquid fraction contains virtually no crystalline riboflavin, and, where appropriate, resuspending the sediment fraction in from 0.5 to 2 parts by volume of water per part by volume of sediment fraction and repeating procedure c.Type: GrantFiled: January 23, 1991Date of Patent: December 8, 1992Assignee: BASF AktiengesellschaftInventors: Tillmann Faust, Joachim Meyer, Georg Wellinghoff, Walter Gosele, Christoph Martin, Johannes Grimmer
-
Patent number: 5166327Abstract: This invention provides a process for producing 3'-deoxy-'-fluorothymidine, which comprises allowing 3'-deoxy-'-fluoro-5'-mesylthymidine (the stating material) to react with an acetylating agent, selected from the group consisting of alkali metal salts of acetic acid, amine salts of acetic acid and ammonium acetate, in an aprotic, ploar solvent to form the 5'-acetyl derivative, and ammonium acetate, in an aprotic, polar solvent to form the 5'-acetyl derivative, and eliminating the 5'-acetyl group from this intermediate, thereby giving the objective 3'-deoxy-'-fluorothymidine.According to the process of this invention described above, the 5'-mesyl derivative can be efficiently acetylated, and 3'-deoxy-'-fluorotymidine can be obtained in a high yield.Type: GrantFiled: July 29, 1991Date of Patent: November 24, 1992Assignee: Yuki Gosei Kogyo Co., Ltd.Inventors: Junji Ohki, Kazuo Itoh, Nobuhiro Mizutani, Shigeki Higuchi, Junko Tanaka
-
Patent number: 5158938Abstract: Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative having advantageous antineoplastic properties.Type: GrantFiled: September 23, 1991Date of Patent: October 27, 1992Assignee: Bristol-Myers Squibb CompanyInventors: Kin S. Lam, Daniel R. Schroeder, Jacqueline Mattei, James A. Matson, Salvatore Forenza
-
Patent number: 5149640Abstract: A galactose transfer product is prepared by a process of allowing a microorganism capable of producing a galactose transfer product of the formula: (Gal).sub.n --R, wherein Gal represents a galactose residue, n represents an integer of 1 to 4 and R represents a galactose receptor to act on a combination of lactose or a galactose donor and a galactose receptor; and collecting the galactose transfer product produced.Type: GrantFiled: December 22, 1989Date of Patent: September 22, 1992Assignee: Ajinomoto Co., Inc.Inventors: Norimasa Oonishi, Kenzo Yokozeki
-
Patent number: 5145780Abstract: An enzyme preparation is obtained containing a nuclease that is produced by a fungus such as Trichoderma, Aspergillus and Fusarium and which remains active even after heating at 100.degree. C. for 30 minutes. This enzyme preparation may be effectively used when it is necessary to decompose nucleic acids at elevated temperature over a prolonged period.Type: GrantFiled: December 16, 1991Date of Patent: September 8, 1992Assignee: Kabushikikaisha Kibun & Kabushikikaisha Kibun FudokemifaInventors: Kunio Oishi, Shuichi Aoi
-
Patent number: 5120645Abstract: A process for the preparation of 2-deoxyuridine, which can be used as a nucleus for compositions useful as therapeutic drugs, in which a strain of the genus Brevibacterium is cultivated on a suitable nutrient medium, e.g. containing glucose as a carbon source. Preferred Brevibacterium strains are strains of Brevibacterium helvolum in particular strains NCIMB 40117 and NCIMB 40116 which 2 strains are claimed per se.Type: GrantFiled: March 16, 1990Date of Patent: June 9, 1992Assignee: Imperial Chemical Industries PLCInventor: Linda A. Naylor
-
Patent number: 5116741Abstract: The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.Type: GrantFiled: January 26, 1989Date of Patent: May 26, 1992Assignee: Genex CorporationInventors: Philip N. Bryan, Michael W. Pantoliano, Michele L. Rollence, Chi H. Wong
-
Patent number: 5093244Abstract: A process for the fermentative production of the deoxyribonucleoside thymidine and/or its corresponding base thymine by aerobically cultivating a strain of the genus Brevibacterium, in particular one of the strains NCIMB 40117 and 40116. The produced thymidine may be used as an intermediate in the production of azidothymidine and active ingredient in a composition for use in the treatment of auto imune deficiency syndrome (AIDS). Biologically pure cultures of strain NCIMB 40014 and variants and mutants derived therefrom are claimed per se.Type: GrantFiled: May 22, 1989Date of Patent: March 3, 1992Assignee: Imperial Chemical Industries PLCInventor: Linda A. Naylor
-
Patent number: 5075225Abstract: A process for synthesizing nucleosides is disclosed. The process includes the reaction of an alkylated nucleoside (such as 7-methylguanosine or 7-methylinosine) with a heterocyclic base (such as adenine, 3-deazaadenine or 1,2,4-triazole-3-carboxamide) in the presence of a nucleoside-forming enzyme to form a nucleoside that includes a glycosyl component, donate by the alkylated nucleoside, bonded to the heterocyclic base.Type: GrantFiled: April 6, 1989Date of Patent: December 24, 1991Assignee: The Texas A&M University SystemInventors: Chi-Huey Wong, William J. Hennen
-
Patent number: 5011774Abstract: A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.Type: GrantFiled: February 28, 1990Date of Patent: April 30, 1991Assignee: Bristol-Myers Squibb Co.Inventors: Vittorio Farina, Daniel A. Benigni, Paul R. Brodfuehrer
-
Patent number: 4970148Abstract: A method of producing dideoxyinosine involving contacting as a substrate 2',3'-dideoxyadenosine with a microorganism which is capable of converting the substrate into 2',3'-dideoxyinosine.Type: GrantFiled: October 7, 1988Date of Patent: November 13, 1990Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Hideyuki Shirae, Katsunori Kobayashi, Hiroshi Shiragami, Yasuo Irie
-
Patent number: 4968606Abstract: The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.Type: GrantFiled: September 15, 1989Date of Patent: November 6, 1990Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Hideyuki Shirae, Koji Kubota
-
Patent number: 4923851Abstract: A composition of matter for increasing the intracellular synthesis of ATP. The composition consists of amino acids, metabolites, electrolyte and a pentose sugar. When applied to wounds, the invention increases the rate of wound repair. When administered orally, the invention increases ATP blood levels and physical performance levels.Type: GrantFiled: October 2, 1989Date of Patent: May 8, 1990Assignee: Raymond A. RoncariInventor: Francis J. Carniglia
-
Patent number: 4904585Abstract: This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineo-plastic activities and is expected as a pharmaceutical as well as a process for the production of the same.Type: GrantFiled: November 2, 1987Date of Patent: February 27, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takashi Harada, Takayuki Tomizawa, Akio Fujii
-
Patent number: 4880736Abstract: Uridine is produced by cultivating in a culture medium a uridine-producing microorganism, which belongs to the genus Bacillus and which is deficient in uridine nucleoside phosphorylase activity and is resistant to a pyrimidine analogue, and recovering the accumulated uridine. This method has the advantage of substantially avoiding the by-production of uracil and uridylic acid.Type: GrantFiled: October 18, 1985Date of Patent: November 14, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Yutaka Tsunemi, Satoru Asahi, Muneharu Doi
-
Patent number: 4840898Abstract: A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine and the temperature during at least a part of the reaction is at or above 65.degree. C. The method is capable of high production rates and high concentrations of the final product.Type: GrantFiled: September 17, 1987Date of Patent: June 20, 1989Assignee: Eastman Kodak CompanyInventors: Jefferson C. Lievense, Joanna D. Sawyer, Anthony J. Terpolilli
-
Patent number: 4840899Abstract: A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above about 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentration of the final product.Type: GrantFiled: September 17, 1987Date of Patent: June 20, 1989Assignee: Eastman Kodak CompanyInventor: James M. Pochodylo
-
Patent number: 4839285Abstract: Cytidine and/or deoxycytidine are produced at high yields by culturing cytidine deaminase activity-defective microbes of the genus Bacillus, which have resistance to pyrimidine analogs and with the ability to produce cytidine and/or deoxycytidine in a medium.Type: GrantFiled: November 25, 1985Date of Patent: June 13, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoru Asahi, Yutaka Tsunemi, Muneharu Doi
-
Patent number: 4835104Abstract: A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.Type: GrantFiled: May 9, 1988Date of Patent: May 30, 1989Assignee: Ajinomoto Co., Inc., Patent & Licensing DepartmentInventors: Kenzo Yokozeki, Hideyuki Shirae, Hiroshi Shiragami, Yasuo Irie, Naohiko Yasuda, Masaru Otani, Toshiya Tanabe
-
Patent number: 4599309Abstract: Yeast cells containing useful substances accumulated therein are contacted with a divalent copper ion in aqueous suspension, thereby discharging low-molecular-weight compounds in the cytoplasm out of the cells. Useful substances can be efficiently recovered both from the discharged compounds and the remaining cells.Type: GrantFiled: December 12, 1983Date of Patent: July 8, 1986Assignee: Nippon Zeon Co., Ltd.Inventors: Yoshinori Ohsumi, Takanori Sato
-
Patent number: 4594320Abstract: Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of microorganism origin is disclosed. The nucleoside phosphorylase source is specified.Type: GrantFiled: March 29, 1983Date of Patent: June 10, 1986Assignee: Yamasa Shoyu Kabushiki KaishaInventor: Tetsuro Fujishima
-
Patent number: 4594321Abstract: Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of microorganism origin is disclosed.Type: GrantFiled: March 29, 1983Date of Patent: June 10, 1986Assignee: Yamasa Shoyu Kabushiki KaishaInventors: Tetsuro Fujishima, Shinji Sakata
-
Patent number: 4565781Abstract: An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the antibiotic, Spicamycin.(1) Color and properties: Weakly acidic white powder(2) Melting point: 215.degree. to 220.degree. C. (decomposed)(3) Specific rotatory power: [.alpha.].sub.D.sup.25 =+15.degree. (C: 0.15, in methanol)(4) Elementary analysis (Found): C: 57.4%, H: 8.3%; N: 15.7%, O: 18.6%(5) Ultraviolet absorption spectrum (maximum):______________________________________ CH.sub.3 OH 264 nm (E.sub.1cm.sup.1% 257) 0.01N NaOH + CH.sub.3 OH 272 nm (E.sub.1cm.sup.1% 226) 0.01N HCl + CH.sub.3 OH 273 nm (E.sub.1cm.sup.1% 258) ______________________________________(6) Infrared absorption spectrum (as measured by the potassium bromide method): As shown in FIG. 2.(7) Solubility in Solvent: Soluble in basic water, dimethyl sulfoxide, methanol, ethanol, n-propanol, and n-butanol.Type: GrantFiled: February 24, 1984Date of Patent: January 21, 1986Assignee: Kirin Beer Kabushiki KaishaInventors: Noboru Otake, Yoichi Hayakawa, Hiroyuki Kawai, Masaya Nakagawa, Kozo Tanabe, Junichiro Mochizuki
-
Patent number: 4381344Abstract: The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed reaction of the appropriately substituted 3-deazapurine with a 2'-deoxyribose donor.Type: GrantFiled: April 25, 1980Date of Patent: April 26, 1983Assignee: Burroughs Wellcome Co.Inventors: Janet L. Rideout, Thomas A. Krenitsky
-
Patent number: 4347315Abstract: 4-Substituted-3-deazapurine ribosides are prepared by the enzymatically catalyzed reaction of 4-substituted-3-deazapurine with a ribose donor.Type: GrantFiled: April 25, 1980Date of Patent: August 31, 1982Assignee: Burroughs Wellcome Co.Inventors: Thomas A. Krenitsky, Janet L. Rideout
-
Patent number: 4189349Abstract: The new antifungal agents 32232 RP and 35391 RP having the probable formulae: ##STR1## respectively, are prepared by cultivating the hitherto unknown microorganism Streptomyces incarnatus DS 26068 (NRRL 8089), under aerobic conditions in an aqueous nutrient medium to obtain 32232 RP which can be converted into the lactam 35391 RP.Type: GrantFiled: September 19, 1977Date of Patent: February 19, 1980Assignee: Rhone-Poulenc IndustriesInventors: Jean Florent, Jean Lunel, Denise Mancy