Nitrite Or Nitrate Patents (Class 436/110)
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Publication number: 20120321724Abstract: A method of measuring in vivo nitric oxide and nitrite levels in individuals by providing a salivary nitrite test substrate, testing salivary nitrite levels with the test substrate, measuring nitrite levels detected in the testing; and correlating the measured nitrite levels with in vivo nitric oxide bio-availability.Type: ApplicationFiled: August 13, 2012Publication date: December 20, 2012Inventor: Nathan S. Bryan
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Publication number: 20120309047Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.Type: ApplicationFiled: May 31, 2012Publication date: December 6, 2012Applicant: University of Maryland, College ParkInventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang
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Publication number: 20120282704Abstract: The present application relates to copolymers having at least one optionally substituted fluoranthene as a first monomer unit and at least one optionally substituted pyrrole as a second monomer unit. The copolymer may, for example, emit green light when exposed to a blue or ultraviolet radiation. Methods of making the copolymer are also disclosed, as well as methods and apparatuses for producing light and detecting nitroaromatics using the copolymer.Type: ApplicationFiled: March 3, 2011Publication date: November 8, 2012Applicant: TONGJI UNIVERSITYInventors: Xingui Li, Dunyin Gu, Meirong Huang
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Publication number: 20120282705Abstract: Provided herein are explosives detection substrates which include an electrospun (electro)sprayed and/or dry spun aromatic polymer, such as polystyrene, and a small molecule fluorophore. Methods for detecting an explosive material using such substrates are also provided.Type: ApplicationFiled: March 28, 2012Publication date: November 8, 2012Applicant: UNIVERSITY OF CONNECTICUTInventors: Yu Lei, Ying Wang
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Patent number: 8304251Abstract: Systems and methods are disclosed to automatically detect the presence of a substance on a test swipe by capturing a background image of the test swipe; applying one or more test chemicals to a test swipe; adjusting the temperature of the test swipe to a predetermined temperature range; capturing an in-situ image of the test swipe after the application of chemical at the predetermined temperature range; subtracting the background image from the in-situ image; generating a difference value from the two images; and searching a known database to identify the substance.Type: GrantFiled: February 18, 2009Date of Patent: November 6, 2012Assignee: Chem Spectra, Inc.Inventors: Jeffrey Haas, Douglas Haas
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Publication number: 20120178172Abstract: Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided.Type: ApplicationFiled: September 24, 2010Publication date: July 12, 2012Applicant: Commissariat a l'energie Atomique et aux energies alternativesInventors: Pierrick Buvat, Lucie Malosse, Alain Siove, Dominique Ades
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Publication number: 20120171702Abstract: A method of determining the concentration of a test fluid sample using a paper-based microfluidic system having a plurality of hydrophilic testing zones, including: a) depositing said test fluid sample on at least one said testing zone; b) depositing a plurality of standard fluid samples or reactives of differing known concentrations on other said testing zones; c) introducing an indicator solution to each said test zone to thereby react with the deposited fluid sample and result in a colour intensity change which is a function of the fluid sample concentration; and d) comparing the differences in colour intensity between the test fluid sample and the standard fluid samples or reactives to thereby determine the concentration of said test fluid sample.Type: ApplicationFiled: June 30, 2010Publication date: July 5, 2012Applicant: Monash UniversityInventors: Wei Shen, Xu Li, Junfei Tian, Gil Garnier
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Patent number: 8173431Abstract: A multi-tier approach for use in a mailroom for detecting bio-threats conveyed by mail. In a first tier procedure, mail entering the mailroom is continuously automatically screened at a mail screening station to detect a potential bio-threat contamination. If a potential bio-threat is detected, an alarm signal is generated, a sample of the potential bio-threat is collected, and a second tier procedure is initiated. The second tier procedure uses a manual test, such as a nucleic acid amplification and detection assay to detect any of a plurality of different specific bio-threats in the sample. If a specific bio-threat is found, appropriate steps are taken to limit spread of the bio-threat and exposure of personnel. A third tier procedure uses a manual assay to check for a specific toxin in background samples collected over a predefined time interval at each mail screening station and in the air handling system for the mailroom.Type: GrantFiled: November 9, 2006Date of Patent: May 8, 2012Assignee: FLIR Systems, Inc.Inventor: Charles J. Call
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Patent number: 8137979Abstract: Improved preconcentrators, particularly MEMs scale preconcentrators which possess a coating comprising polymers of intrinsic microporosity (PIMs). There is further provided devices comprising the preconcentrator, and methods of preparation and use. There is particular benefit directed to the use of a MEMs scale heater coated with the PIMs for use in hand-held or field portable chemical detection devices. The polymer of intrinsic microporosity comprises a polymer, with a monomer repeat unit of Formula I wherein A is one or more optionally substituted aryl, heterocyclic, cycloalkyl or bicycloalkyl rings, ? is greater than 5, preferably 5 to 10000, and X may be selected from CH, CH2, O, S, N or NH.Type: GrantFiled: June 25, 2008Date of Patent: March 20, 2012Assignee: QinetiQ LimitedInventors: David J. Combes, Timothy I Cox, Ian C Sage
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Patent number: 8134122Abstract: Systems, methods and computer program products for the multi-modal detection of particles are described herein. An embodiment of the present invention is a particle detector that includes a first chamber wherein analyte particles are subjected to a first particle detection mechanism, and a second chamber coupled to the first chamber, wherein the analyte particles are subjected to a second particle detection mechanism, and wherein the detection characteristics of second particle detection mechanism are orthogonal to detection characteristics of the first particle detection mechanism.Type: GrantFiled: January 19, 2010Date of Patent: March 13, 2012Assignee: The Mitre CorporationInventor: Samar K. Guharay
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Publication number: 20120045840Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: ApplicationFiled: February 7, 2011Publication date: February 23, 2012Applicant: NDSU-RESEARCH FOUNDATIONInventors: Johnson Thomas, Philip Boudjouk
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Publication number: 20120003746Abstract: Field test kits for detecting explosive substances including a combination of reagents for sequentially testing for perchlorates, nitro aromatic compounds, nitroamines, nitroesters, chlorates, bromates, peroxides and nitrates are discussed. The reagents in the kits may contain methylene blue, methylene blue in a basic solution, and an acidified aromatic amine solution. Methods for employing the test kits are discussed, the methods being suitably adapted to detect the moieties suspected of being present. The kits may include a reagent for detecting explosive perchlorates, the reagent being methylene blue. The kits also include a reagent for detecting explosive nitroamines and nitroesters, the reagent being an acidified aromatic amine solution. The aromatic amine solution also can detect nitro aromatic explosives after a strong basic hydroxide has first been applied to the suspected substance.Type: ApplicationFiled: February 1, 2010Publication date: January 5, 2012Applicant: MISTRAL DETECTION LTD.Inventor: Shai Amisar
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Publication number: 20110287552Abstract: A compound represented by the general formula (I) [R1 and R2 are amino groups that substitute at adjacent positions on the benzene ring; R3 and R4 are halogen atoms; R5 and R6 represent hydrogen atom, an acyl group or an acyloxy(C1-6 alkyl) group; R7 and R8 represent —(CH2)p—N(R9)(R10) (p is 1 to 4, and R9 and R10 represent —(CH2)n—COOH (n is 1 to 4))], which is useful for measuring a reactive nitrogen species existing in cells such as nitrogen monoxide or peroxynitrite at high sensitivity over a long period of time.Type: ApplicationFiled: December 4, 2009Publication date: November 24, 2011Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Saki Izumi
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Patent number: 8053243Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including nitrosylated proteins such as S-nitrosylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a nitrosylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc. In some embodiments, other moieties on the protein may be altered or blocked before reaction of the protein with the detection entity.Type: GrantFiled: April 12, 2005Date of Patent: November 8, 2011Assignee: The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen, Albert van der Vliet, Karina Ckless, Niki Reynaert
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Publication number: 20110212533Abstract: Methods for determining the concentration of nitrates in several types of water samples by photochemical reduction without the use of toxic materials such as cadmium or hydrazine, and having an approximately 100% reduction efficiency are described. A water sample mixed with a buffered aqueous solution including ammonium salts and EDTA is irradiated using ultraviolet light having wavelengths effective for photochemical conversion of nitrate and nitrite ions (NOx) to detectable species. The resulting species may be quantitatively determined by diazotization using sulfanilamide followed by coupling with N-(1-napthyl)ethylenediamine dihydrochloride which produces a water-soluble azo dye having a magenta color which may be colorimetrically measured at 540 nm from which the nitrate and nitrite concentration in the sample is determined.Type: ApplicationFiled: August 9, 2010Publication date: September 1, 2011Applicant: Hach CompanyInventors: Scott A. Tucker, Lynn M. Egan
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Patent number: 8003399Abstract: A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.Type: GrantFiled: August 31, 2005Date of Patent: August 23, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Xuedong Song, Rosann Marie Matthews Kaylor
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Patent number: 7989211Abstract: This invention relates to the development of a new Raman enhancing reagent and a surface-enhanced Raman scattering (SERS) method for rapid and ultra-sensitive detection and identification of perchlorate (ClO4?) and other anions such as technetium (TcO4?), uranium and nitrate in environmental samples. The method involves the synthesis of controlled gold nanoparticles which are modified with amine functional groups such as 2-(dimethylamino)ethanethiol and N,N,N-trimethylaminethiol. These functionalized Au nanoparticles were found to be reactive with perchlorate and other anions and can be used to detect these anions by Raman spectroscopy at ultra low concentrations in complex environmental matrices. This invention overcomes the limitations of currently-available analytical techniques by offering an inexpensive, rapid, ultra-sensitive, and real-time identification and detection of perchlorate and other anions.Type: GrantFiled: December 22, 2009Date of Patent: August 2, 2011Assignee: UT-Battelle, LLCInventors: Baohua Gu, Chuanmin Ruan, Wei Wang
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Publication number: 20110177606Abstract: An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte.Type: ApplicationFiled: June 30, 2009Publication date: July 21, 2011Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.Inventors: Itamar Willner, Ran Tel-Vered, Michael Riskin
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Patent number: 7955855Abstract: Methods and devices for detecting the presence of a NO forming material (e.g., a material that can form, or is, a nitrogen monoxide molecule) are disclosed based on detection of fluorescence exhibited by NO molecules in a first vibrationally excited state of a ground electronic state. Such excited NO molecules can be formed, for example, when small amounts of explosives are photodissociated. By inducing fluorescence of the material, a distinct signature of the explosive can be detected. Such techniques can be performed quickly and with a significant standoff distance, which can add to the invention's utility. In another aspection of the invention, methods and apparatus for generating electromagnetic radiation are disclosed. Such methods and apparatus can be used in conjunction with any detection method disclosed herein.Type: GrantFiled: July 10, 2009Date of Patent: June 7, 2011Assignee: Massachusetts Institute of TechnologyInventors: Mordechai Rothschild, Charles M. Wynn, John J. Zayhowski, Roderick R. Kunz
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Patent number: 7927883Abstract: A method and apparatus for near real-time in-situ soil solution measurements is presented. An outer sleeve is placed in soil where ionic concentrations of organic or inorganic species are to be measured. A porous section connects with the outer sleeve (the porous section initially loaded with distilled water) equilibrates with the solution present in soil pores to form a solution to be measured. The initial distilled water is displaced within the porous section by a removable plunger. After substantial equilibration of the solution to be measured within the apparatus, the plunger is removed and a removable probe replaced. The probe may be an Ion Selective Electrode, or a transflection dip probe. The probe then may be used under computer control for measurement of solution properties. The Ion Selective Electrode may measure nitrate (NO3?) concentrations. The transflection dip probe may be read with spectrometer with an input deuterium light source.Type: GrantFiled: November 10, 2008Date of Patent: April 19, 2011Assignee: The Regents of the University of CaliforniaInventors: Atac Tuli, Jan W. Hopmans, Tamir Kamai, Benjamin D. Shaw
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Patent number: 7915001Abstract: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.Type: GrantFiled: June 27, 2008Date of Patent: March 29, 2011Assignee: Universite De LiegeInventors: Jean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
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Patent number: 7910376Abstract: A method for detecting trace explosives which includes obtaining a sample believed to contain explosives residue and contacting the sample and a carrier container containing the sample with a reagent. The sample and the carrier is illuminated by an appropriate laser or other light source while it is contained within a light tight box. The sample and the carrier is observed during the elimination to determine photoluminescence of the sample as an indication that it contains trace explosives. The reagent may be an alkaline containing substance, a lanthanide complex, a lanthanide complex containing sensitizing ligands or nanocrystals.Type: GrantFiled: May 21, 2004Date of Patent: March 22, 2011Inventor: Roland E. Menzel
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Publication number: 20110045599Abstract: Disclosed are a system and method for regulating flow in an exemplary fluidic device comprising a fluidic stream carrying a transport medium, sample and one or more reagents for analysis and synthesis of reaction products. The flow rate of the fluidic stream is maintained constant by adjusting the flow rate of transport medium to compensate for the introduction of sample and reagents. An embodiment controls the flow rate of transport medium using a pump, a back pressure regulator, and a variable-sized orifice. Single and multiple channel embodiments are disclosed.Type: ApplicationFiled: December 31, 2008Publication date: February 24, 2011Applicant: OI ANALYTICALInventors: Gary L. Erickson, Craig Ranger
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Patent number: 7875456Abstract: An automated discrete fluid sample analyzer includes a sample preparation module. The sample preparation module includes a well configured to receive a sample deposited by a pipettor and a sample preparation device in fluid communication with the well. The fluid sample is transferred from the well to the sample preparation device, and the sample preparation device prepares the fluid sample. The pipettor then aspirates the prepared fluid sample. The prepared fluid sample may be transferred from the sample preparation device back to the well, and the pipettor aspirates the prepared fluid sample from the well. In one embodiment, the sample preparation device includes a receptacle having a catalyst disposed therein. The catalyst may include a noble metal catalyst, such as cadmium. In another embodiment, the sample preparation device includes an ultraviolet lamp configured to apply ultraviolet light to the fluid sample.Type: GrantFiled: December 10, 2008Date of Patent: January 25, 2011Assignee: WESTCO Scientific Instruments, Inc.Inventors: Joseph Platano, Antonio Gagliarducci, Ausilio Pieralisi
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Patent number: 7867728Abstract: The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator.Type: GrantFiled: August 22, 2005Date of Patent: January 11, 2011Assignee: Bayer HealthCare LLCInventors: Karen L. Marfurt, Mary Ellen Warchal-Windham
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Publication number: 20110003396Abstract: The present invention relates to a porphyrinogen based sensor having selective binding affinity for an explosive chemical. Upon binding of the target molecule, the porphyrinogen derivative undergoes a detectable adsorption and emission of electromagnetic radiation.Type: ApplicationFiled: May 15, 2007Publication date: January 6, 2011Applicant: SYDDANSK UNIVERSITETInventors: Jan O. Jeppesen, Kent A. Nielsen
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Patent number: 7846740Abstract: The invention relates to a method for detecting an explosive substance which contains chlorate, bromate and/or organic peroxide, wherein a suspect substance is contacted with a first reagent, which is a strongly acid solution of at least one primary or secondary aromatic amine, whereby chlorate or bromate type explosive affords a distinct coloration; and in the absence of such coloration, contacting the same sample (in contact with the first reagent) with a second reagent, which is a solution comprising cations of at least one transition metal, whereby the presence of organic peroxides in the sample, which has been hydrolyzed at least partly to hydrogen peroxide by the strong acid of the first reagent, affords a distinct coloration. The invention further relates to a kit containing separate first and second reagents; a container of mixed reagents for detecting peroxide; and a kit including such container.Type: GrantFiled: February 2, 2005Date of Patent: December 7, 2010Assignee: Mistral Detection Ltd.Inventor: Shai Amisar
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Publication number: 20100291698Abstract: A method of the invention is a method of detecting nitramines and nitrate esters believed to be present on a sampling substrate. In the method, a sampling substrate is exposed to a first reagent that is formulated to react with nitramine- and nitrate ester-type explosives to release nitrite. The sampling substrate is then exposed to a second reagent that contains an acid to react with the nitrite and a diaminoaromatic present in either the first or second reagent, to form a triazole that will luminesce. Another method of the invention combines this process for nitramine- and nitrate ester-based explosives detection with a technique to detect nitroaromatic-based explosives using luminescent polymers, for a three-step process for the detection of explosives in these three classes.Type: ApplicationFiled: May 1, 2007Publication date: November 18, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: William C. Trogler, Jason Sanchez, Sara Toal, Zheng Wang, Regina E. Dugan
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Patent number: 7833481Abstract: A fully integrated portable screening system includes a main housing and a contact pad. The contact pad is removably positioned in the main housing and covered by at least one sample sheet. The contact pad is preferably constituted by a cylindrical baton which carries a roll of sample collection sheets. A test subject interacts with the contact pad, leaving a trace sample on the sample collection sheet. The contact pad is then placed within the main housing and the trace sample is exposed to a test medium designed to interact with a specific analyte of interest potentially present in the trace sample. After exposure to the test medium, the sample sheet is subjected to a testing mechanism which exposes any interaction between the test medium and the analyte of interest to produce a test result.Type: GrantFiled: September 22, 2006Date of Patent: November 16, 2010Assignee: RedXDefense, LLCInventors: Khaled F. Eltomi, Jack Kotowicz, Pratheev Sabaratnam Sreetharan, Regina Elvira Dugan
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Publication number: 20100279420Abstract: A stabilised thylakoid membrane formulation comprising thylakoid membranes in a buffered solution and liposomes, wherein the formulation has a ratio of chlorophyll/liposomes of at least about 10:1. The invention further comprises a method for detecting or quantifying the presence of toxic molecules in a fluid sample, comprising obtaining a stabilised thylakoids membranes formulation; and assessing the photosynthetic efficiency of the thylakoid membranes formulation in the presence of said sample, whereby the molecules are detected when the photosynthetic efficiency is measurably different in the presence versus in the absence of the sample. The present invention also comprises kits using the stabilised thylakoid membranes formulation for detecting and/or quantifying the toxic molecule in a fluid sample.Type: ApplicationFiled: April 21, 2010Publication date: November 4, 2010Inventors: François BELLEMARE, Nathalie Boucher, Lucie Lorrain
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Patent number: 7759123Abstract: A method and apparatus for removing concentrated spots of collected particulates from an impact collection surface, and transferring those particulates into a container suitable for preparing a liquid sample. A jet of fluid can be utilized to remove and transfer the particulates. If a liquid jet is employed, care is taken to minimize the quantity of liquid to avoid unnecessarily diluting the sample. A mechanical scraper can alternatively be employed to remove and transfer the particulates into the container. The scraper can be rinsed with liquid or vibrated to remove the particulates. Alternatively, the portion of the surface containing a specific spot of particulates can be removed and placed into a container.Type: GrantFiled: March 21, 2006Date of Patent: July 20, 2010Assignee: MesoSystems Technology, Inc.Inventors: Charles J. Call, Patrick T. Call, Vanessa M. Kenning, Eric Hanczyc, Andrew Kamholz
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Patent number: 7745227Abstract: A system for analysis of explosives. Samples are spotted on a thin layer chromatography plate. Multi-component explosives standards are spotted on the thin layer chromatography plate. The thin layer chromatography plate is dipped in a solvent mixture and chromatography is allowed to proceed. The thin layer chromatography plate is dipped in reagent 1. The thin layer chromatography plate is heated. The thin layer chromatography plate is dipped in reagent 2.Type: GrantFiled: August 11, 2004Date of Patent: June 29, 2010Assignee: Lawrence Livermore National Security, LLCInventor: Jeffrey S. Haas
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Patent number: 7731900Abstract: The present invention concerns a body fluid testing device (10) for analyzing a body fluids, comprising a test media tape (30) adapted to collect the body fluid, a supply portion (100) storing an uncontaminated section of the test media tape, a storage portion (110) for storing a contaminated section of the test media tape, an exposure portion positioned between the supply portion and the storage portion, the exposure portion being adapted to expose a section of the test media tape to the body fluid. An important aspect is a tip portion (20) for exposing a test medium to body fluid application. The application further concerns a test media cassette for housing test media. Another aspect is a testing device and method that employs illumination of a test medium at the site for body fluid application.Type: GrantFiled: May 6, 2005Date of Patent: June 8, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Hans-Peter Haar, Joachim Hoenes, Hans List, Maria Manser, Karl Miltner, Rudolf Pachl, Volker Zimmer
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Publication number: 20100112715Abstract: The present invention generally relates to methods for modulating the optical properties of a luminescent polymer via interaction with a species (e.g., an analyte). In some cases, the present invention provides methods for determination of an analyte by monitoring a change in an optical signal of a luminescent polymer upon exposure to an analyte. Methods of the present invention may be useful for the vapor phase detection of analytes such as explosives and toxins. The present invention also provides methods for increasing the luminescence intensity of a polymer, such as a polymer that has been photobleached, by exposing the luminescent polymer to a species such as a reducing agent.Type: ApplicationFiled: August 2, 2007Publication date: May 6, 2010Inventors: Timothy M. Swager, Samuel W. Thomas, III
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Patent number: 7695990Abstract: The invention relates to a method for producing an electrical leadframe (10), in particular for a light-emitting diode component, having at least one first electrical connection conductor (2) and at least one second electrical connection conductor (3).Type: GrantFiled: December 23, 2005Date of Patent: April 13, 2010Assignee: Osram Opto Semiconductors GmbHInventors: Joerg-Erich Sorg, Gertrud Kraeuter
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Publication number: 20100081205Abstract: Periodic mesoporous organosilicas (PMO) which incorporate an optically active molecule into the material for use as an optical indicator of target binding. This material combines the stability, selectivity, and high density of binding sites characteristic of the PMO with the sensitivity and selectivity of the optically active molecule. The material undergoes a change when exposed to a sample containing a target molecule. The change can be observed by visual inspection or through the use of fluorescence spectra.Type: ApplicationFiled: August 17, 2006Publication date: April 1, 2010Inventors: Mazyar Zeinali, Brandy J. White, Paul T. Charles, Michael A. Markowitz
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Patent number: 7687275Abstract: The present invention relates to a method for amplifying the detected signal in a gas sensor. More specifically, the present invention relates to a method for increasing the concentration of the gas which is being detected in a sample or increasing the concentration of a gas which is directly obtained from the gas in the sample by chemical reaction. The gas which is to be detected is nitric oxide (NO). In particular, the method concerns the selective conversion of NO to NO2 which allows a threefold amplification of the number of analyte molecules in NO trace gas analysis in a single amplification cycle. Subsequent reduction or thermal decomposition of the obtained NO2 can provide NO again, which can again be introduced in a new amplification cycle. Multiple (n) amplification cycles can provide a sensitivity amplification by a factor 3n. The method can be combined with a multitude of detection methods and tolerates a high humidity.Type: GrantFiled: September 4, 2006Date of Patent: March 30, 2010Assignee: Koninklijke Philips Electronics N.V.Inventor: Dirk Burdinski
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Patent number: 7670842Abstract: The present invention provides a method for discriminating an organic farmland from a conventional farmland, comprising; (a) measuring an amount of nitrogen isotope in a soil sample of a farmland; (b) calculating a nitrogen isotope index according to the formula (I) using the resultant nitrogen isotope value and (c) determining whether the farmland belongs to an organic farmland or a conventional farmland. According to the present invention, it is possible to objectively discriminate an organic farmland from a conventional farmland or discriminate an organic crop from a conventional crop.Type: GrantFiled: April 12, 2003Date of Patent: March 2, 2010Inventors: Hee Myong Ro, Woo Jung Choi
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Publication number: 20100047916Abstract: Methods and devices for detecting the presence of a NO forming material (e.g., a material that can form, or is, a nitrogen monoxide molecule) are disclosed based on detection of fluorescence exhibited by NO molecules in a first vibrationally excited state of a ground electronic state. Such excited NO molecules can be formed, for example, when small amounts of explosives are photodissociated. By inducing fluorescence of the material, a distinct signature of the explosive can be detected. Such techniques can be performed quickly and with a significant standoff distance, which can add to the invention's utility. In another aspection of the invention, methods and apparatus for generating electromagnetic radiation are disclosed. Such methods and apparatus can be used in conjunction with any detection method disclosed herein.Type: ApplicationFiled: July 10, 2009Publication date: February 25, 2010Applicant: Massachusetts Institute Of TechnologyInventors: Mordechai Rothschild, Charles M. Wynn, John J. Zayhowski, Roderick R. Kunz
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Patent number: 7655473Abstract: A method for automatically determining the concentration of nitrite in a liquid sample includes: determination of the extinction of the liquid sample at a wavelength ? of 150-250 nm, addition of a nitrite reducing agent to the liquid sample, determination of the extinction of the reduced liquid sample at a wavelength ? of 150-250 nm, and determination of the nitrite concentration from the difference between the concentration values obtained from the extinctions of the non-reduced and the reduced liquid samples.Type: GrantFiled: February 13, 2006Date of Patent: February 2, 2010Assignee: Hach Lange GmbHInventor: Andreas Golitz
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Publication number: 20090246881Abstract: A system and method for detecting trace explosives is provided that utilizes a lumnescent reagent, such as blue-fluorescent biphenyl compound, to simultaneously detect multiple nitrogen-based explosives on a sample substrate. The test reagent is mixed with a solvent to improve mixing and maximize the dissolution of the reagent and any trace explosives present on the substrate. A thin film of reagent is applied to the substrate either before or after the substrate contacts a sample area to be tested. Heated air is then applied to the substrate to improve the sample reading. A light source is utilized to illuminate the reagent and expose any quenched portions of the substrate that indicate the presence of an explosive. Quenched portions may be detected visually, or utilizing an analyzing apparatus, such as a fluorimeter or camera. A computer may also be utilized to interpret and record test results.Type: ApplicationFiled: September 21, 2007Publication date: October 1, 2009Applicant: REDXDEFENSE, LLCInventors: Sarah Josepha Toal, Jennifer Marie Sievering
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Patent number: 7521251Abstract: A method for estimating the sulfur content in the fuel of an internal combustion engine equipped with a catalyser capable of storing a quantity of sulfur and NOx groups. The method provides use of a current sulfur concentration value (Sold) and a correction of the current sulfur concentration value (Sold) in order to obtain a new sulfur concentration value (Snew). The method includes the steps of estimating a first value (NOxstored1) of the total quantity of NOx groups stored in the catalyser (11) by means of a model of NOx group production by the engine, estimating a second value (NOxstored2) of the total quantity of NOx groups stored by the catalyser by means of a model of storage of the catalyser, and determining an additive correction coefficient (D) as the difference between the first estimated value (NOxstored1) and the second estimated value (NOxstored2).Type: GrantFiled: July 21, 2006Date of Patent: April 21, 2009Assignee: Magneti Marelli Powertrain S.p.A.Inventors: Daniele Ceccarini, Matteo De Cesare, Luca Poggio
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Patent number: 7485464Abstract: An automated discrete fluid sample analyzer includes a sample preparation module. The sample preparation module includes a well configured to receive a sample deposited by a pipettor and a sample preparation device in fluid communication with the well. The fluid sample is transferred from the well to the sample preparation device, and the sample preparation device prepares the fluid sample. The pipettor then aspirates the prepared fluid sample. The prepared fluid sample may be transferred from the sample preparation device back to the well, and the pipettor aspirates the prepared fluid sample from the well. In one embodiment, the sample preparation device includes a receptacle having a catalyst disposed therein. The catalyst may include a noble metal catalyst, such as cadmium. In another embodiment, the sample preparation device includes an ultraviolet lamp configured to apply ultraviolet light to the fluid sample.Type: GrantFiled: April 30, 2003Date of Patent: February 3, 2009Assignee: Westco Scientific Instruments, Inc.Inventors: Joseph Platano, Antonio Gagliarducci, Ausilio Pieralisi
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Publication number: 20080318333Abstract: A method for combined measurement of release of nitrite (NO2?) and nitric oxide (NO) from a probe containing nitric oxide, such as an intravascular medical device immersed in an aqueous solution within a first vessel, comprises conveying nitric oxide (NO) released directly from the probe to a nitric oxide analysis apparatus. Nitrite is removed from a first vessel, which may e.g. comprise a head-space chamber, and transferred to a purge vessel where NO2? is transformed to nitric oxide (NO), which is conveyed to the nitric oxide analysis apparatus. A selector valve arranged upstream of the nitric oxide analysis apparatus is operated to selectively allow one of the directly released nitric oxide (NO) and the nitrite-derived nitric oxide (NO) into the apparatus. Directly released nitric oxide may be continuously flushed away from the first vessel.Type: ApplicationFiled: December 13, 2006Publication date: December 25, 2008Applicant: MILLIMED A/SInventors: Kent Hoier Nielsen, Lars Niklas Larsson
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Patent number: 7410612Abstract: A gunpowder particle test kit for determining gunpowder residue includes a transparent sleeve having a closed end and an open folded end sealed with a clip forming a sealed cavity carrying a test strip and a crushable ampoule carrying a diphenylamine solution. The test strip has an adhesive area on a front surface. An opaque label is provided on a rear surface on the sleeve opposite the adhesive area. In use, the clip is removed to open the cavity, the test strip removed and applied to possible residue areas on a subject. The strip is returned to the cavity; the clip reapplied to seal the cavity. Thereafter, the ampoule is crushed to release the solution, which develops a distinctive coloration observable against the label to indicate the presence of possible gunpowder residue.Type: GrantFiled: December 4, 2003Date of Patent: August 12, 2008Inventor: John H. Carrington
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Patent number: 7407626Abstract: A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood testing composition, a calcium testing composition, a nitrite testing composition, a ketone testing composition and a pH testing composition. The medical test kit also includes a plurality of corresponding indicative spectra to each of its units such that a health condition of a user can easily be interpreted. Furthermore, an interactive reference chart is provided for guiding a user for the use of the kit. The kit is suitable for use for the public and is capable of encouraging self health care of society.Type: GrantFiled: April 20, 2004Date of Patent: August 5, 2008Inventor: Qing-Hua Zhao
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Patent number: 7393649Abstract: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.Type: GrantFiled: March 12, 2003Date of Patent: July 1, 2008Assignee: Universite de LiegeInventors: Jean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
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Patent number: 7368292Abstract: A system and method for identifying explosive or other target materials includes the steps of irradiating a first location and a second location spaced apart from the first location from a sample suspected of including explosives with ultraviolet, visible or infrared light, measuring reflected light emanated from the first sample location (R1) and reflected light emanated from the second sample location (R2), and calculating a normalized difference in reflectivity (?R/ R), wherein R=(R1+R2)/2 is an average reflectivity. A differential reflection spectrum (DRS) is then generated for the sample where ?R=R2?R1 is the difference of the reflectivities of the first and the second sample location. One or more explosives if present are identified in the sample based on comparing the DRS for said sample to at least one reference DRS.Type: GrantFiled: April 11, 2006Date of Patent: May 6, 2008Assignee: University of Florida Research Foundation, Inc.Inventors: Rolf E. Hummel, Ann Marie Fuller, Claus Schollhorn, Paul H. Holloway
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Patent number: 7338638Abstract: The invention is directed to a trap material use in a chemical trace detection portal for detecting trace amounts of contraband, and more particularly for detecting vapors and particles emitted from drugs and explosive devices. The trap material is made of a metallic foam material, such as aluminum foam metal, copper foam metal, stainless steel foam metal, or a silica-carbon foam metal, which have high thermoconductivity and reduced density, as compared to conventional trap materials, thereby ensuring that the internal temperature of the subject trap rapidly achieves the temperature required during desorbing of the trace materials.Type: GrantFiled: August 13, 2003Date of Patent: March 4, 2008Assignee: GE Homeland Protection, Inc.Inventors: William J. McGann, Kevin J. Perry, Sherry L. Lepine
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Patent number: 7332345Abstract: A chemical sensing apparatus and method for the detection of sub parts-per-trillion concentrations of molecules in a sample by optimizing electron utilization in the formation of negative ions is provided. A variety of media may be sampled including air, seawater, dry sediment, or undersea sediment. An electrostatic mirror is used to reduce the kinetic energy of an electron beam to zero or near-zero kinetic energy.Type: GrantFiled: November 12, 2002Date of Patent: February 19, 2008Assignee: California Institute of TechnologyInventors: Murray R. Darrach, Ara Chutjian