Amine And Quaternary Ammonium Patents (Class 436/111)
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Publication number: 20140106463Abstract: The present invention provides methods for determining the presence of oxidizing salts. According to the current invention, analyte is collected on a swipe and subsequently heated to a temperature sufficient to release a detectible vapor phase component of the oxidizing salt. The vapor phase component passes reacts with a pH sensitive molecule. Reaction of the vapor phase product with the pH sensitive molecule produces a detectible change in response intensity.Type: ApplicationFiled: October 12, 2012Publication date: April 17, 2014Inventors: Lara Beth Wald, Gregory Charles Frye-Mason
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Publication number: 20140093970Abstract: A method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis.Type: ApplicationFiled: September 30, 2013Publication date: April 3, 2014Applicant: THE CLEVELAND CLINIC FOUNDATIONInventors: Raed Dweik, Ibrahim Hanouneh, Nizar Zein, David Grove, Frank S. Cikach, JR.
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Patent number: 8685739Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.Type: GrantFiled: April 14, 2008Date of Patent: April 1, 2014Inventors: Carolyn Slupsky, Thomas Marrie
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Patent number: 8668874Abstract: A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.Type: GrantFiled: June 2, 2010Date of Patent: March 11, 2014Assignee: Arizona Board of Regents for and on Behalf of Arizona State UniversityInventors: Nongjian Tao, Erica Forzani, Rodrigo A Iglesias
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Patent number: 8663995Abstract: There are provided a method for analyzing an aqueous ammonium carbamate solution whereby the composition of an unreacted-gas absorber outlet liquid can be specified in real time, and a method for operating an unreacted gas absorber by use of the same.Type: GrantFiled: May 12, 2010Date of Patent: March 4, 2014Assignee: Toyo Engineering CorporationInventors: Eiji Sakata, Kenji Yoshimoto, Shuhei Nakamura
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Publication number: 20140024127Abstract: The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines. The amine-recovering method comprises the steps (A) and (B). In the step (A), the gas or solution is brought into contact with a solid adsorbent so that the adsorbent may retain the amines. In the step (B), the amines retained by the adsorbent in the step (A) are eluted out by use of a basic compound-containing organic solvent. The solid adsorbent has a substituent group represented by —SO3M (M is H or an alkali metal).Type: ApplicationFiled: July 16, 2013Publication date: January 23, 2014Applicant: KABUSHIKI KAISHA TOSHIBAInventors: Hiroko WATANDO, Takashi Kuboki
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Patent number: 8623296Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: GrantFiled: August 4, 2010Date of Patent: January 7, 2014Assignee: Applied Biosystems, LLCInventors: Sean M. Desmond, Zbigniew T. Bryning, John Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Publication number: 20140004615Abstract: There is provided at least a kit for marking, monitoring and/or detecting alteration of a fuel comprising: (i) at least one marker; and (ii) at least one substance, wherein the substance is capable of interacting with at least one laundering agent. In particular, the kit may comprise a substance which is capable of interacting with at least one laundering agent to protect and/or prevent the marker from being absorbed, adsorbed, or partially or completely removed by the laundering agent. There is also provided a method of marking fuel, the method comprising marking a fuel with: (i) at least one marker; and (ii) at least one substance, wherein the substance is capable of interacting with at least one laundering agent.Type: ApplicationFiled: January 27, 2012Publication date: January 2, 2014Applicant: DECIPHER PTE. LTD.Inventors: Timothy George Wilkinson, Robert Deva Arul Paulmer
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Patent number: 8617895Abstract: The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA).Type: GrantFiled: September 22, 2005Date of Patent: December 31, 2013Assignee: Tripath Imaging, Inc.Inventors: William Alan Fox, William Carl Ray, III
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Publication number: 20130337568Abstract: The invention is directed towards methods and compositions for identifying the presence of surfactants in water. The invention is quite superior over the prior art because it can form a colorful complex in half the time, avoid the need for difficult separation steps, use a safer solvent and avoid the formation of messy foam. The invention involves adding to the water a cobalt thiocyanate reagent, pre-prepared from a cobalt salt and a thiocyanate salt, which forms a colorful complex with the surfactant. Chloroform is then added to the water. The cobalt reagent causes the virtually all of the surfactant to form a colored complex which rapidly migrates into the chloroform and prevents the surfactant from foaming. Once in the chloroform, a UV-vis spectrometer can easily and precisely identify the type and amount of surfactant that was in the water.Type: ApplicationFiled: June 18, 2012Publication date: December 19, 2013Inventors: Viviane Pacheco e Silva, Luiz Wanderley Bratfisch Pace, Edmir Carone, JR.
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Patent number: 8603830Abstract: The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination.Type: GrantFiled: March 1, 2012Date of Patent: December 10, 2013Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Alfred Weber, Andrea Engelmaier, Heinz Anderle, Hans-Peter Schwarz
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Patent number: 8597577Abstract: An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described. Biomolecular sensors with optical resonator microfabricated with integrated waveguide operation can be in a microfluidic flow cell.Type: GrantFiled: February 18, 2011Date of Patent: December 3, 2013Assignee: California Institute of TechnologyInventors: Richard C. Flagan, Amnon Yariv, Jason Gamba, Naresh Satyan, Jacob Sendowski, Arseny Vasilyev
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Publication number: 20130309775Abstract: It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column.Type: ApplicationFiled: July 24, 2013Publication date: November 21, 2013Applicants: Nippon Filcon Co., Ltd., Wako Pure Chemical Industries, Ltd.Inventors: Yoshinori Inoue, Kimiko Yoshida, Mamoru Kubota, Hitoshi Uemori
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Patent number: 8586367Abstract: The present invention is concerned with the analysis of polar metabolites and provides methods for analyzing polar metabolites including extracting a biological sample with a extraction buffer containing a phase separator and a volatile neutral ammonium salt under conditions which allow for immediate disruption of cells in the biological sample, separating the polar metabolites in the extract by chromatography, and analyzing the separated polar metabolites. Moreover, a method for quenching a biological sample containing cellular material is contemplated.Type: GrantFiled: July 7, 2010Date of Patent: November 19, 2013Assignee: BASF Plant Science Company GmbHInventors: Gerd Balcke, Tilmann B. Walk, Martin Dostler, Ralf Looser, Susan Carvalho
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Publication number: 20130302902Abstract: A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A? are independently chosen from N—R1, N—R2, and O such that both A and A? are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.Type: ApplicationFiled: July 15, 2013Publication date: November 14, 2013Inventors: Ling Zang, Yanke Che
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Patent number: 8569071Abstract: The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.Type: GrantFiled: September 8, 2009Date of Patent: October 29, 2013Assignee: DH Technologies Development Pte. Ltd.Inventors: Subodh B. Nimkar, Subhasish Purkayastha, Darryl Pappin, Scott Daniels
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Publication number: 20130280817Abstract: The invention relates to a multifunctional detector for gaseous compounds, or mixtures of gaseous compounds, selected from NH2Cl, NHCl2, NCl3, total chlorine, NOx, where x=1 or 2, O3, and X2, where X?Cl, Br, or I, in a sample, said detector including a first sensor including an iodide and a reactive compound selected from starch, amylose, amylopectin, xyloglucan, xylan, chitosan, glycogen, polyvinyl alcohol, cellulose or a cellulose compound, ?-cyclodextrin, theobromine, and polypropylene block polymers and polyethylene oxide block polymers, included in a block of sol-gel material that is absorbent in the UV spectrum but not in the visible spectrum. The invention also relates to the uses of said detector.Type: ApplicationFiled: December 14, 2011Publication date: October 24, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Thu-Hoa Tran-Thi, Julien Garcia, Thi Dinh Nguyen, Trung-Hieu Nguyen
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Publication number: 20130224870Abstract: Solid phase fluorescent labeling reagents (SPR) are described that simultaneously capture and label analytes, and then efficiently release the labeled-analytes under mild conditions (SCaLER).Type: ApplicationFiled: August 26, 2011Publication date: August 29, 2013Applicant: The Texas A&M University SystemInventors: Gyula Vigh, Roy T. Estrada, III
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Patent number: 8513023Abstract: A method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject was disclosed. The method comprises (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject, and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.Type: GrantFiled: October 25, 2012Date of Patent: August 20, 2013Assignee: Norgine BVInventors: Hans-Jürgen Gruss, Ronald Oude Elferink, Dirk De Waart, Bruno Stieger
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Patent number: 8513022Abstract: A method for determining the amount of a chemical species in a sample, in particular the amount of weak acid dissociable cyanide or total cyanide in a sample, and an apparatus for performing said method. The method comprises the steps of: i) treating the sample to liberate the chemical species into a gaseous stream; ii) directing the gaseous stream to a scrubber; iii) absorbing the chemical species into a scrubber solution; and iv) determining the amount of chemical species absorbed into the scrubber solution, wherein any remaining chemical species not absorbed into the scrubber solution is directed or recirculated to the scrubber in the gaseous stream and step iii) is repeated to increase absorption of the chemical species prior to performing step iv).Type: GrantFiled: December 18, 2008Date of Patent: August 20, 2013Assignee: Cyantific Instruments Pty LtdInventor: Fraser John Ross
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Patent number: 8492163Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets.Type: GrantFiled: January 31, 2011Date of Patent: July 23, 2013Assignee: DH Technologies Development Pte. Ltd.Inventors: Subhasish Purkayastha, Subhakar Dey, Scott B. Daniels
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Publication number: 20130183766Abstract: A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than ?5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.Type: ApplicationFiled: March 23, 2011Publication date: July 18, 2013Applicants: University of Utah Research Foundation, University of UtahInventors: Ling Zang, Yanke Che
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Patent number: 8486708Abstract: A fluorescence sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A? are independently chosen from N—R1, N—R2, and O such that both A and A? are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can optionally be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.Type: GrantFiled: January 29, 2010Date of Patent: July 16, 2013Assignee: University of Utah Research FoundationInventors: Ling Zang, Yanke Che
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Publication number: 20130177994Abstract: Methods for the chiral separation and quantitative determination of the d- and l-enantiomers for amphetamine and methamphetamine in bodily fluids and tissues are provided. The method comprises providing a bodily fluid or tissue sample from a subject, extracting target analyte(s) from the sample, followed by eluting on a liquid chromatography column comprising a chiral stationary phase to yield an eluent, which is then analyzed for the presence of the analytes using a mass analyzer.Type: ApplicationFiled: January 4, 2013Publication date: July 11, 2013Applicant: CLINICAL REFERENCE LABORATORY, INC.Inventor: Clinical Reference Laboratory, Inc.
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Patent number: 8481324Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.Type: GrantFiled: December 2, 2009Date of Patent: July 9, 2013Assignee: Technion Research and Development Foundation Ltd.Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
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Publication number: 20130137183Abstract: A method of screening aircraft passengers and/or cargo comprising loading an aircraft with passengers, cargo or both, circulating air within the aircraft so that the air is in contact with the passengers and/or cargo, expelling some of the circulated air from the aircraft, diverting a portion of the air being expelled from the aircraft through a chemical filter configured to retained evidence of a target substance, and analyzing the chemical filter to detect the presence of a target substance within the aircraft.Type: ApplicationFiled: November 26, 2012Publication date: May 30, 2013Applicant: Teknoscan Systems, Inc.Inventor: Teknoscan Systems, Inc.
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Patent number: 8389232Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.Type: GrantFiled: May 13, 2009Date of Patent: March 5, 2013Assignee: The Regents of the University of CaliforniaInventor: Rebecca Braslau
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Patent number: 8383064Abstract: A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences, an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, wherein, each of the chambers contains less than 270 picograms of probe and the reagent reservoir has a volume less than 1000,000,000 cubic microns.Type: GrantFiled: June 1, 2011Date of Patent: February 26, 2013Assignee: Silverbrook Research Pty LtdInventors: Mehdi Azimi, Kia Silverbrook
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Publication number: 20130045501Abstract: A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided.Type: ApplicationFiled: March 25, 2011Publication date: February 21, 2013Inventors: Lin Hu, Haipeng Hu, Yinfei Wu
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Patent number: 8377713Abstract: A method of simultaneously detecting peroxide and nitrogen-based explosives includes the steps of applying a conversion reagent to a sample, the conversion reagent oxidizing in the presence of peroxide and inorganic nitrate explosives; applying a test reagent including a luminescent compound to the sample; exciting the luminescent compound with ultraviolet light; and simultaneously determining the presence of one or more explosives based on quenching, brightening or a shift in wavelength of the luminescence over time. Explosives may also be detected based on color changes of the sample. Optionally, phase transfer reagents, catalysts, colorimetric agents and zinc dust may be added to improve detection of explosives. Alternatively, an assay-type method may be utilized wherein a sample is added to the conversion and/or test reagents and the reagent is spotted on a substrate before exposure to ultraviolet light.Type: GrantFiled: June 2, 2009Date of Patent: February 19, 2013Assignee: Redxdefense, LLCInventors: Dale R Miller, Sarah J Toal, Russell P Watson
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Publication number: 20130023005Abstract: An apparatus to separate and analyze components of a liquid sample include a high performance liquid chromatograph with a mass spectrometer utilizing desorption electrospray ionization. This permits separation and evaluation of different components in a liquid sample. Further, this can be combined with online derivation via reactive DESI and, further, can be used with further electrochemistry.Type: ApplicationFiled: July 19, 2012Publication date: January 24, 2013Inventors: Hao Chen, Yun Zhang, Zongqian Yuan, Howard Dewald
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Patent number: 8357540Abstract: Amino-containing materials can be attached to polymeric materials having a pendant amine capture group that includes a fluoroalkoxycarbonyl group. An amino-containing material can react with the pendant amine capture group by a nucleophilic substitution reaction. The product of the reaction is an alcohol and a pendant group that contains a carbonylimino group. The reaction results in the connection of the amino-containing material to the polymeric material. The polymeric materials are often disposed on a surface of a substrate and the connection of the amino-containing material to the polymeric material results in the immobilization of the amino-containing material on the substrate.Type: GrantFiled: September 17, 2007Date of Patent: January 22, 2013Assignee: 3M Innovative Properties CompanyInventors: George G. I. Moore, Charles M. Leir, Rahul R. Shah
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Publication number: 20130011926Abstract: A vapochromic gold-copper complex [AuL2(Cu(Y)n)2](X)3 exhibiting luminescence is provided, where L is an N-heterocyclic carbene; Y is a heteroatom-containing ligand; X is an anion, and n is an integer having a value of 1 or 2, and solvates thereof. A reaction of [AuL2(Cu(Y)n)2](X)3 with water vapor or an organic compound vapor, for example, affords a modified complex that yields a change in luminescence color under UV excitation. These tricationic vapochromic materials exhibit large changes in the emission through ligand substitution reactions between the solid complex and vapors, which permit use in luminescent vapochromic sensors.Type: ApplicationFiled: June 29, 2012Publication date: January 10, 2013Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada,Inventors: Vincent J. Catalano, Christoph E. Strasser
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Publication number: 20130004940Abstract: A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple.Type: ApplicationFiled: November 23, 2010Publication date: January 3, 2013Inventors: Haipeng Hu, Jianfeng Wang
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Patent number: 8323979Abstract: The invention provides a method for labeling an analyte comprising a primary amino group, the method comprising: a. a labeling process comprising reacting the analyte with a dialdehyde in the presence of a label, wherein the label bears a charge, and b. an analysis process comprising subjecting the labeled analyte to MS, preferably LC-MS-MS. Herein, preferably, the labeling process comprises reacting an analyte with a dialdehyde, wherein the dialdehyde carries a label bearing a charge, to provide a labeled analyte carrying the charge. The present invention also provides a labeling method to provide a labeled analyte carrying a charge, wherein the labeling method comprises a labeling process comprising reacting an analyte with a dialdehyde, wherein the analyte comprises a primary amino group and wherein the dialdehyde carries a label bearing the charge. The dialdehyde is preferably an aromatic dialdehyde, most preferably an aromatic 1,2- or 1,3-dicarboxaldehyde.Type: GrantFiled: March 19, 2008Date of Patent: December 4, 2012Assignee: Brains Online Holding B.V.Inventors: Thomas Ivo Franciscus Hubert Cremers, Lutske Aafke Anna de Jong, Wijnand Sjoerd Faber
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Publication number: 20120301969Abstract: In general, the present invention provides a reliable assay for the quantitative determination of p-aminophenol in an aqueous sample. More particularly, the present invention provides a rapid enzyme-based assay for the quantitative determination of acetaminophen in a sample. The assay employs a xylenol chromophore and a catalyst that is preferably a weak oxidizer. The assay provides reliable results in the presence or absence of N-acetylcystiene (NAC) and can therefore be used to monitor acetaminophen levels during NAC treatment. Methods and kits for determining acetaminophen concentration in an aqueous sample are also provided.Type: ApplicationFiled: July 9, 2012Publication date: November 29, 2012Applicant: Sekisui Diagnostics, LLCInventors: Michael Bulger, Jan Holinsky
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Patent number: 8318504Abstract: In one aspect a method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject, comprises: (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject; and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.Type: GrantFiled: May 14, 2009Date of Patent: November 27, 2012Assignee: Norgine BVInventors: Hans-Jürgen Gruss, Ronald Oude Elferink, Dirk de Waart, Bruno Stieger
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Patent number: 8299222Abstract: The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.Type: GrantFiled: November 3, 2009Date of Patent: October 30, 2012Assignee: The Board of Trustees of the University of ArkansasInventors: Samuel M. Owens, Frank Ivy Carroll, Philip Abraham
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Publication number: 20120264222Abstract: An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.Type: ApplicationFiled: December 7, 2010Publication date: October 18, 2012Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.Inventors: Itamar Willner, Ran Tel-Vered, Michael Riskin
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Patent number: 8283117Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.Type: GrantFiled: June 25, 2008Date of Patent: October 9, 2012Assignee: Korea Research Institute of Standards and ScienceInventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
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Patent number: 8257666Abstract: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e. Polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene.Type: GrantFiled: February 8, 2012Date of Patent: September 4, 2012Assignee: California Institute of TechnologyInventors: Stephen R. Quake, Hou-Pu Chou
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Publication number: 20120220039Abstract: A method and system for detecting residual poison in human body are provided. Using the disclosed HPLC-Chip-mass spectrometry (MS)/MS and/or HPLC-MS/MS method to detect the residual poison, the method of the present invention mainly includes sample preparation, liquid chromatography and mass spectrometry. The method of the present invention has advantages of low sample size, high specificity, low detection limit, high sensitivity, low cost, high accuracy and stability, etc.Type: ApplicationFiled: November 5, 2010Publication date: August 30, 2012Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Karl Wah Keung Tsim, Tina Tingxia Dong, Kevin Yue Zhu, Ka Wing Leung, Tiejie Wang
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Publication number: 20120210948Abstract: A method of calibrating a biological detector can include training a biological detector to detect a calibration compound, wherein the calibration compound comprises an odor that is detectable by the biological detector and is not used in an environment for which the biological detector is trained to detect odors, presenting the biological detector with a device comprising the calibration compound, and determining whether the biological detector will alert to the calibration compound.Type: ApplicationFiled: February 20, 2012Publication date: August 23, 2012Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Kenneth G. Furton, Katylynn Beltz
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Publication number: 20120202240Abstract: The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.Type: ApplicationFiled: July 23, 2010Publication date: August 9, 2012Inventors: Hans-Peter Deigner, Matthias Kohl, David Enot, Theresa Koal, Matthias Keller
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Patent number: 8231833Abstract: A whispering gallery mode resonator based optical sensor assembly comprises a flow channel permeable to optical energy and first and second optical waveguides adjacent to a section of the flow channel and adapted to be in first and second evanescent field couplings respectively with the section such that the section forms a whispering gallery mode resonator. The resonator is responsive to an optical signal conveyed in the first optical waveguide and communicates a second optical signal to the second optical waveguide indicative of a resonance wavelength of the whispering gallery mode resonator. A detector optically coupled to the second optical waveguide detects the output signal. A signal processor detects a shift in the output signal responsive to an analyte fluid flowing through the flow channel. The shift is indicative of the identity of at least one constituent of the analyte fluid.Type: GrantFiled: March 17, 2010Date of Patent: July 31, 2012Assignee: Lockheed Martin CorporationInventors: Scott Maurer, Stephanie Groves, Kee Koo
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Patent number: 8197758Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.Type: GrantFiled: June 22, 2007Date of Patent: June 12, 2012Assignee: Montana State UniversityInventors: Edward A. Dratz, Paul A. Grieco
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Patent number: 8197759Abstract: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.Type: GrantFiled: August 31, 2009Date of Patent: June 12, 2012Assignee: Montana State UniversityInventors: Edward A. Dratz, Paul A. Grieco
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Patent number: 8183051Abstract: A kit for determining residual chlorine or chloramine amount of a sample; comprising: a means for containing a PVA solution as an indicator, and another means for containing a reducing indicator. Said reducing indicator would be oxidized by a reaction with residual chlorine or chloramine and said PVA indicator induces a dye by reaction with oxidized compound such as free iodine; wherein intensity of said dye would be changed depending upon the residual chlorine or chloramine amount of the sample.Type: GrantFiled: September 7, 2008Date of Patent: May 22, 2012Inventors: Nooshin Mirkheshty, Sayyed Ali Alavi
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Publication number: 20120115239Abstract: Vapochromic coordination polymers useful for analyte detection are provided. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes. The polymer has the general formula MW[M?X(Z)Y]N wherein M and M? are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. One embodiment provides [Metal(CN)2]-based coordination polymers with vapochromic properties, such as Cu[Au(CN)2]2 and Zn[Au(CN)2]2 polymers.Type: ApplicationFiled: October 21, 2011Publication date: May 10, 2012Inventors: Julie LEFEBVRE, Michael Iacov KATZ, Daniel B. LEZNOFF
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Publication number: 20120115177Abstract: Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.Type: ApplicationFiled: August 5, 2009Publication date: May 10, 2012Applicant: ANAZYME, LLCInventor: John Rodenrys