Carboxylic Acid Patents (Class 436/129)
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Publication number: 20100273661Abstract: A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine.Type: ApplicationFiled: June 11, 2008Publication date: October 28, 2010Applicants: SmithKline Beecham Corporation, BG Medicine IncInventors: Yang Qiu, Dilip Rajagopalan, Lei Zhu, Susan C Connor, Guanghui Hu, David Maclean, Doris Damian, Amir Handzel, Rajalakshmi Balasubramanian
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Publication number: 20100267148Abstract: A mass spectrometric method for determining the position of unsaturation in a compound is disclosed.Type: ApplicationFiled: June 29, 2010Publication date: October 21, 2010Applicant: The University of WollongongInventors: Stephen James Blanksby, David Grant Harman, Michael Christopher Thomas, Todd William Mitchell
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Publication number: 20100255596Abstract: Citrate analysis methods are described. In some embodiments, the methods can be used to analyze citrate in an electrodeposition bath.Type: ApplicationFiled: April 3, 2009Publication date: October 7, 2010Applicant: Xtalic CorporationInventors: NAZILA DADVAND, BRENDAN THOR KEENE
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Publication number: 20100233756Abstract: Kibble-type animal feeds and pet foods including a vegetable protein-based core matrix and a coating of a fat and at least one additive are described. The coating may include a probiotic enriched coating. Methods of forming the kibble-type animal feeds and pet foods are also described. Probiotic coating for a kibble showing acceptable stability and bioactivity are disclosed and methods for assessing the bioactivity of a probiotic in a food composition are also described.Type: ApplicationFiled: September 9, 2009Publication date: September 16, 2010Inventors: Gregory Dean Sunvold, John Leslie Brent, JR., Patrick Joseph Corrigan, Michael Griffin Hayek
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Publication number: 20100209937Abstract: The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field.Type: ApplicationFiled: June 4, 2008Publication date: August 19, 2010Inventors: Chris D. Geddes, Michael J.R Previte
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Publication number: 20100184643Abstract: The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakary-ocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.Type: ApplicationFiled: August 22, 2007Publication date: July 22, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam N. Goldfarb, Loretta L. Delehanty
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Publication number: 20100173346Abstract: Markers are provided for detecting coronary artery disease. Levels of these markers are indicative of a patient being at risk of having or developing coronary artery disease.Type: ApplicationFiled: March 24, 2008Publication date: July 8, 2010Applicant: BG MEDICINE, INC.Inventors: Aram Adourian, Doris Damian, Amir Handzel
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Publication number: 20100160276Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: ApplicationFiled: August 13, 2009Publication date: June 24, 2010Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Publication number: 20100136705Abstract: A method for measuring only a concentration of a peroxycarboxylic acid in an equilibrium mixture containing peroxycarboxylic acid and hydrogen peroxide, comprising the following steps a) and b); a) adding potassium iodide to the equilibrium mixture to cause the generation of iodine and providing the resulting mixture as a measurement sample; and b) measuring the amount of light that goes through the measurement sample to determine only the concentration of a peroxycarboxylic acid.Type: ApplicationFiled: April 25, 2008Publication date: June 3, 2010Inventors: Sachiko Kojima, Taro Furuta, Toshio Kasai, Dock-Chil Che
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Patent number: 7708894Abstract: To simply and accurately determine the concentration of a water treating agent in thermal equipment upon management of a supply amount of the water treating agent, a method of controlling a supply amount of a water treating agent according to the present invention includes the steps of: supplying a water treating agent containing a scale inhibitor selected from chelating agents to a water-supply system of thermal equipment; collecting a water sample from the thermal equipment; quantitatively determining the scale inhibitor in the collected water sample; and determining a concentration of the water treating agent in the thermal equipment on the basis of a quantitative value of the scale inhibitor.Type: GrantFiled: March 23, 2007Date of Patent: May 4, 2010Assignee: Miura Co., Ltd.Inventor: Hiroyuki Mitsumoto
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Patent number: 7704751Abstract: A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.Type: GrantFiled: October 25, 2006Date of Patent: April 27, 2010Assignee: 3M Innovative Properties CompanyInventors: Michael C. Palazzotto, Neal A. Rakow, Michael S. Wendland
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Patent number: 7695980Abstract: The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.Type: GrantFiled: January 25, 2006Date of Patent: April 13, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Dieter Heindl, Rupert Herrmann, Wolfgang Jenni, Heribert Maerz
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Patent number: 7695973Abstract: The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein under conditions where both glycated and non-glycated protein bind to the support in making a second bound protein measurement under conditions where glycated protein is bound to the support and non-glycated protein is not substantially bound. Diagnostic devices and kits comprising the methods of the present invention are also provided.Type: GrantFiled: February 7, 2007Date of Patent: April 13, 2010Assignee: Scripps Laboratories, Inc.Inventors: Ralph P. McCroskey, Cameron E. Melton
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MICROWAVE TRIGGER METAL-ENHANCED CHEMILUMINESCENCE (MT MEC) AND SPATIAL AND TEMPORAL CONTROL OF SAME
Publication number: 20100003695Abstract: The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using metallic geometric structures for spatially and temporally controlling the biological and chemical reactions.Type: ApplicationFiled: February 25, 2008Publication date: January 7, 2010Applicant: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTEInventors: Chris D. Geddes, Michael Previte -
Publication number: 20090318369Abstract: The present invention provides various biomarkers of Alzheimer's Disease (AD). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of AD, methods of determining predisposition to AD, methods of monitoring progression/regression of AD, methods of assessing efficacy of compositions for treating AD, methods of screening compositions for activity in modulating biomarkers of AD, methods of treating AD, as well as other methods based on biomarkers of AD.Type: ApplicationFiled: August 15, 2008Publication date: December 24, 2009Inventors: Lisa A. Paige, Matthew W. Mitchell, Anne Evans, Don Harvan
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Publication number: 20090298188Abstract: The present invention relates in general to the discovery of urinary succinate as a novel biomarker of kidney disease. More specifically, the invention provides for the measurement of succinate in urine samples that has great potential for the easy and early diagnosis of kidney damage and would allow early prediction of kidney disease and therapeutic intervention.Type: ApplicationFiled: May 27, 2009Publication date: December 3, 2009Applicant: University of Southern CaliforniaInventor: Janos Peti-Peterdi
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Publication number: 20090186419Abstract: The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors.Type: ApplicationFiled: January 20, 2006Publication date: July 23, 2009Applicant: Agency for Science ,Technology and ResearchInventors: Jackie Y. Ying, Hsiao-Hua Yu, Emril Mohamed Ali
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Publication number: 20090130655Abstract: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead. The Raman spectra of the product formed by binding of the sensor bead and an analyte in a sample is detected for determining whether the analyte exists in the sample. In embodiment, the pH of the solution of metal nanoparticles is controlled to keep at 10, and the concentration of the Raman dye is controlled to keep between 1×10?6M and 2×10?6M for reducing the size of the nanoaggregate.Type: ApplicationFiled: November 14, 2008Publication date: May 21, 2009Applicant: NATIONAL CHUNG CHENG UNIVERSITYInventors: Laikwan Chau, Tzyy-Schiuan Yang, Ping-Ji Huang, Tai-Tsung Lin
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Publication number: 20090104705Abstract: Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. Disclosed herein are new marker compounds, including ascorbylated 4-hydroxy-2-nonenal, that are useful as biomarkers of oxidative stress.Type: ApplicationFiled: May 23, 2006Publication date: April 23, 2009Inventors: Jan Frederik Stevens, John D. Sowell, Balz Frei
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Patent number: 7494822Abstract: Method of identification and quantitative analysis of carboxylic acid(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said carboxylic acid with a stable isotope labeled reagent, and is added to a sample containing said carboxylic acid. Said carboxylic acid in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said carboxylic acid are made from a plot of ion ratio of said converted carboxylic acid to said internal standard versus carboxylic acid concentration.Type: GrantFiled: September 30, 2003Date of Patent: February 24, 2009Inventors: Hoa D. Nguyen, Trinh D. Nguyen, Duc T. Nguyen
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Publication number: 20090018870Abstract: A new method for preventing chronic disease is described. The method comprises the act of using the result of any biometric test for an individual's levels of omega-6 or omega-3 fatty acids as an input in any computerized analysis that determines an economic outcome for the tested individual. This outcome will encourage improved health behavior, which will lead to lowered incidence of chronic disease, improved physical and mental health, improved employee performance, and lower health care costs.Type: ApplicationFiled: November 26, 2007Publication date: January 15, 2009Inventor: Joseph Thomas Weishaar
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Publication number: 20080261317Abstract: The disclosed methods address the identification of myocardial ischemia and myocardial infarction using metabolomics, as well as the identification of metabolic products whose differential expression over time is indicative of myocardial ischemia and/or myocardial infarction.Type: ApplicationFiled: September 6, 2005Publication date: October 23, 2008Inventors: Michael A. Fifer, Marc S. Sabatine, Robert Gerszten
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Patent number: 7435600Abstract: A method of measuring the extent of cure of a binder in a fibrous product is provided. The method comprises (a) providing a sample of a fibrous product, the fibrous product comprising fibers and a binder, (b) subjecting the sample to infrared spectroscopy to generate a spectral analysis, and (c) determining a binder cure ratio of the binder in the sample using the spectral analysis. The binder has carboxylic acid groups and alcohol groups that crosslink to form ester groups as the binder cures, and the binder cure ratio comprises a ratio between infrared absorption corresponding to a bond of the carboxylic acid groups in the binder and infrared absorption corresponding to a bond of the ester groups in the binder.Type: GrantFiled: June 23, 2004Date of Patent: October 14, 2008Assignee: Johns ManvilleInventor: Richard Thomas Packard
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Publication number: 20080187952Abstract: The invention provides methods for measuring cellular response to ionization radiation (IR). The invention also provides a plurality of diagnostic and prognostic cancer biomarkers for assessing cellular response to IR.Type: ApplicationFiled: January 31, 2008Publication date: August 7, 2008Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Gabriela G. Cezar, Alan M. Smith
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Publication number: 20080160225Abstract: The present invention pertains to compounds and polymers which incorporate a boronic acid sensor group (SG) of the formula (I): wherein: J is independently —CH2— or —CH2CH2—; n is independently 0, 1, 2, or 3; and each RR, if present, is independently a ring substituent; and wherein the ring attachment (i.e., where sensor group is attached) is via the 3-, 4-, 5-, or 6-ring position. Such compounds and polymers are useful in the selective chemical detection and/or quantitation of alpha-hydroxy carboxylic acids, such as lactic acid/lactate and malic acid/malate. The present invention also pertains to methods of preparing such compounds and polymers; methods and assays which employ these compounds and polymers; devices (e.g., holographic sensors) and kits for use in such methods and assays, etc.Type: ApplicationFiled: January 31, 2006Publication date: July 3, 2008Applicant: CAMBRIDGE ENTERPRISE LIMITEDInventors: Christopher Robin Lowe, Felicity Kate Sartain, Xiaoping Yang
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Patent number: 7368512Abstract: A method of detecting unreacted termini within a dendritic structure is achieved by exposing a dendrimer to a single generating compound capable of bonding to and tagging a deprotected but uncoupled termini. A signal generated by the signal generating compound to an otherwise uncoupled termini provides detection of the unreacted termini.Type: GrantFiled: September 14, 2004Date of Patent: May 6, 2008Assignee: University of South FloridaInventors: George Newkome, Charles N. Moorefield, Claus Weis
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Publication number: 20070196233Abstract: An object of the present invention is to provide a biosensor and a method for immobilizing a physiologically active substance, by which preconcentration effects can be obtained at a pH that is equivalent to or higher than the isoelectric point of the physiologically active substance and the physiologically active substance can be covalently bound to the surface. The present invention provides a biosensor comprising a solid substrate to which a polymer having a primary or secondary amino group is bound, by which a physiologically active substance can be chemically immobilized following preconcentration of the substance at a pH that is equivalent to or higher than the isoelectric point of the substance.Type: ApplicationFiled: February 22, 2007Publication date: August 23, 2007Applicant: FUJIFILM CorporationInventors: Taisei Nishimi, Toshihide Ezoe
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Patent number: 7220553Abstract: The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of Russell's viper venom to the plasma sample and measuring the clotting time or the residual FXa activity chromogenically.Type: GrantFiled: April 18, 2002Date of Patent: May 22, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventor: Valeria Fung-Hwei Chu
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Patent number: 7195923Abstract: The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral flow test strip or vertical flow test strip devices having negatively charged carboxyl or carboxylate groups and hydroxyboryl groups immobilized and interspersed on a solid support matrix. The solid support matrix may include derivatives of cellulose (e.g., carboxy cellulose) derivatized with carboxylic acid (e.g., carboxylate, carboxyl) groups and hydroxyboryl compounds including phenylboronic acid (e.g., phenylborate), aminophenylboronic acid, boric acid (e.g., borate), or other boronic acid (e.g., boronate) compounds. The present invention is usefi.il for monitoring glycation or glycosylation of hemoglobin or albumin for monitoring glycemic control (e.g., glycemia in diabetes).Type: GrantFiled: January 31, 2002Date of Patent: March 27, 2007Assignee: Scripps Laboratories, Inc.Inventors: Ralph P. McCroskey, Cameron E. Melton
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Patent number: 7081347Abstract: A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro-thromboxane B2 that falls within the second, third, or fourth quartile is indicative of aspirin resistance and an elevated risk of a recurrent cardiovascular event.Type: GrantFiled: September 24, 2003Date of Patent: July 25, 2006Assignee: McMaster UniversityInventors: Salim Yusuf, Jack Hirsh, John Eikelboom
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Patent number: 7063983Abstract: By utilizing a pH indicator having known color change characteristics, an accurate determination of the pH of a binder surface, and hence the amount of cure of a polycarboxylic acid based binder on the fiberglass fibers, can be easily determined for polycarboxylic binder based fiberglass materials used in insulation and composite applications. Based on these results, the manufacturing line used to make these bindered materials may be adjusted to ensure adequate curing at maximum efficiency while minimizing operating costs and reducing waste.Type: GrantFiled: May 31, 2002Date of Patent: June 20, 2006Assignee: Owens Corning Fiberglas Technology, Inc.Inventor: Liang Chen
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Patent number: 7056685Abstract: The invention provides natural ligands of various receptors and methods of identifying modulators of various receptors using the ligands. Methods of using the modulators to treat diseases or disorder associated with dysfunction of the receptor are also provided.Type: GrantFiled: November 5, 2003Date of Patent: June 6, 2006Assignee: Amgen Inc.Inventors: Jin-Long Chen, Lei Ling, Hui Tian
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Patent number: 7026166Abstract: The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.Type: GrantFiled: January 21, 2003Date of Patent: April 11, 2006Assignee: Chiron CorporationInventors: Daniel J. Suich, Ronald N. Zuckermann
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Patent number: 6960450Abstract: An object of the present invention is to provide a reagent for activating and unmasking antigens in a immuno-tissue-chemical staining. A slice of tissue cells on a slide glass is heated or heated under pressurization by an electric pot, autoclave, microwave oven, scalder, or constant-temperature bath for a sufficient time period in CCA aqueous solution of suitable pH and CCA concentration, thereby activating and unmasking antigenicity of antigen masked by aldehyde fixation.Type: GrantFiled: March 8, 2002Date of Patent: November 1, 2005Inventor: Shigeki Namimatsu
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Patent number: 6951759Abstract: There is disclosed a method for detecting the presence of bacterial vaginosis in a female subject comprising the steps of: obtaining a sample from the vaginal region of the subject; detecting acetic acid present in the sample; and correlating the presence of detected acetic acid with the presence of bacterial vaginosis.Type: GrantFiled: August 14, 2002Date of Patent: October 4, 2005Assignee: Osmetech PLCInventors: Paul James Travers, Amjad Nissar Chaudry, Andrew John Tummon, Martin James Henery
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Patent number: 6939718Abstract: A liquid chromatography-electrospray ionization mass spectrometry method is capable of separating and identifying different prostaglandin isomers, including PGD2 and PGE2. Unlike traditional gas chromatography methods, little sample preparation and no derivatization are required. The chromatography is performed under acidic conditions that are optimal for separating the isomers. A basic sheath flow liquid is added to the chromatographic eluent, resulting in high ionization efficiency when the electrospray ionization is performed in negative ion mode. Additionally, by altering the energy at which the ionization is performed, tandem mass spectra of the two isomers can be made to differ as a result of the different relative energies of the two isomers.Type: GrantFiled: January 11, 2002Date of Patent: September 6, 2005Assignee: SurroMed, LLCInventors: Rajendra Singh, Halhong Zhou
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Patent number: 6921668Abstract: A method for determining the presence of an infection in a liquid sample comprising the steps of: lowering the pH of the liquid sample so as to drive short-chain fatty acids present in the liquid sample, acetic acid in particular, to the gaseous phase; detecting short-chain fatty acids, ammonia and, optionally amine species present as gases in a headspace associated with the liquid sample using a detector which is sensitive to the presence of short-chain fatty acids, ammonia and, optionally, amine species, particularly conductive and semi-conductive polymer sensors; and correlating the presence of detected short-chain fatty acids, ammonia and, optionally, amine species with the presence of the infection.Type: GrantFiled: November 26, 2001Date of Patent: July 26, 2005Assignee: Osmetech PLCInventors: Paul James Travers, Martin James Henery, John Charles Plant, Sean Sydney Aiken, Andrew John Tummon, Alexander Samuel McNeish, Janet Elizabeth Manning, Amjad Nissar Chaudry
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Patent number: 6818450Abstract: The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“NMG”), N-methyl-aminomethylphosphonic acid (MAMPA) or aminomethylphosphonic acid (“AMPA”)) in an aqueous mixture thereof, using infrared spectroscopy. The present invention is also directed to a process for oxidizing an N-(phosphonomethyl)iminodiacetic acid substrate to form a N-(phosphonomethyl)glycine product, and as part of the process, measuring the concentration of at least one reactant, product or byproduct of the oxidation reaction using the analytical method of the present invention and controlling the oxidation process in response to the measurement taken.Type: GrantFiled: May 17, 2002Date of Patent: November 16, 2004Assignee: Monsanto Technology LLCInventors: David R. Eaton, Walter Gavlick, Gary Klopf, Arnold Hershman, Denis Forster
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Publication number: 20030224470Abstract: The use of statins for the control of hypercholesterolemia is continually increasing. Although the side effects of statins are relatively uncommon, muscle myopathies may develop in response to statin therapy. The invention is the discovery of a correlation between statin related myopathy based on the presence of 3-methylglutaconic acid (3MGA) in the urine. This correlation allows for the screening of both symptomatic and asymptomatic individuals for statin related myopathy.Type: ApplicationFiled: March 12, 2003Publication date: December 4, 2003Inventor: Paul S Phillips
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Publication number: 20030175851Abstract: A method and an equipment for monitoring the syntrophic relations between different parts of a bacterial consortium in the process fluid of a biological process plant, such as a biological gas plant or waste water treatment plant, through an accurate measurement of the content of the individual volatile fatty acids in consecutive samples of the process fluid, employing small quantities of process fluid.Type: ApplicationFiled: April 22, 2003Publication date: September 18, 2003Inventors: Peter Frode Pind, Birgitte Kiaer Ahring
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Publication number: 20030148533Abstract: The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjuction with nuclear manegtic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the present invention may be taken orally during the same clinical exam. The metabolic information can be derived from blood, urine or other fluids to provide a comprehensive profile of glucogenic metabolism. The subject matter of the present invention may be applied to the study of metabolic dysfunction related to obesity, diabetes, HIV infection and a variety of other disease conditions.Type: ApplicationFiled: May 1, 2001Publication date: August 7, 2003Inventors: Craig R. Malloy, A. Dean Sherry, John G. Jones
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Publication number: 20030096422Abstract: Methods and apparatus for the solvent extraction of analytes from a sample are provided. A solvent system is used to extract analytes under elevated temperatures and constant regulated pressures under dynamic conditions. The extracted analytes may then be further analyzed.Type: ApplicationFiled: November 16, 2001Publication date: May 22, 2003Inventors: Eng Shi Ong, Soo On Woo, Yuk Lin Yong, Siti Norasikin Binte Apandi
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Publication number: 20030044996Abstract: There is disclosed a method for detecting the presence of bacterial vaginosis in a female subject comprising the steps of:Type: ApplicationFiled: August 14, 2002Publication date: March 6, 2003Applicant: Osmetech PLC, a British CompanyInventors: Paul James Travers, Amjad Nissar Chaudry, Andrew John Tummon, Martin James Henery
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Publication number: 20030008336Abstract: A method and kit for detecting a disease state, characterized by a localized hypoxic/ischemic cell population or other cells with altered metabolisms similar to hypoxic/ischemic cells, in an animal is described. The method comprising the step of determining the concentration of succinate in a bodily fluid sample of said animal.Type: ApplicationFiled: August 21, 2002Publication date: January 9, 2003Inventors: Jack Edward Juni, Howard J. Saz, Becky S. Debruyn
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Patent number: 6482654Abstract: The invention provides methods of detecting shikimic acid comprising the steps of: oxidizing shikimic acid with periodic acid or a reagent comprising periodate and periodic acid; adding a strong base to generate a chromophore; stabilizing the chromophore with sulfite; detecting the presence of the chromophore; and optionally quantifying the amount of the chromophore. The methods of the invention can be performed directly with tissue extracts, preferably plant tissue extracts.Type: GrantFiled: February 8, 2000Date of Patent: November 19, 2002Assignee: Syngenta LimitedInventors: Thomas Houston Cromartie, Nicholas David Polge
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Publication number: 20020127732Abstract: The invention relates to a process for the diagnosis of illnesses, pathologic states as well as physiological measurement units, which is based on the immobilization of recognition structures by means of a specific linker at specific functional polymer surfaces.Type: ApplicationFiled: October 22, 2001Publication date: September 12, 2002Inventors: Gotz Nowak, Elke Bucha
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Publication number: 20020019056Abstract: A novel method for the qualitative and quantitative analysis of dicarboxylic acids in biological samples is provided. The method includes the steps of estering the acid component of the sample and subsequently analyzing the esterified sample using tandem mass spectroscopy using atmospheric pressure ionization techniques in the positive ion mode. The method is particularly useful in the determination of methylmalonic acid in biological samples, and thus, the diagnosis of vitamin B12 deficiency.Type: ApplicationFiled: April 17, 2001Publication date: February 14, 2002Inventors: Bori Shushan, Mark Kushnir, Gabor Komaromy-Hiller
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Patent number: 6329207Abstract: A wet chemical indicator for peracetic acid solutions includes an indicator for peracetic acid and an inhibitor. The inhibitor is selected to inhibit a selected peracetic acid concentration in a reproducible sample of a solution containing peracetic acid. The indicator exhibits an observable change when the selected concentration of peracetic acid is exceeded. In this manner, a rapid indication of whether the peracetic acid solution is of a required minimum strength is provided.Type: GrantFiled: February 11, 1999Date of Patent: December 11, 2001Assignee: Steris CorporationInventors: Christopher M. Fricker, Brian C. Wojcieck, Paul D. Walkley, Jr., Robert F. Korb, Giridhar Shamsunder, Elijah L. Booker, Jr., Kathleen A. Hughes, Lewis I. Schwartz
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Patent number: 6329208Abstract: Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3-13C3]propionate are presented. This indicates that a direct measure of gluconeogenesis, pyruvate recycling, and anaplerosis may be obtained from a single 13C NMR spectrum of suitably prepared blood or urine samples collected after oral administration of enriched propionate, acetaminophen, and phenylacetate.Type: GrantFiled: July 16, 1998Date of Patent: December 11, 2001Assignee: Board of Regents, The University of Texas SystemInventors: John G. Jones, A. Dean Sherry, F. M. H. Jeffrey, G. Larry Cottam, Craig. R. Malloy
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Patent number: 6100097Abstract: A method for identifying methyl methacrylate (MMA) in the liquid part of a liquid/powder system used to form artificial finger nails and toenails. The chemistry used to identify MMA in liquid monomers provides an accurate and inexpensive way to monitor the use of MMA in liquid monomers in violation of a ban of MMA by the Food and Drug Administration (FDA) for purposes of creating artificial finger nails and toenails.Type: GrantFiled: April 13, 1998Date of Patent: August 8, 2000Assignee: OPI Products, Inc.Inventors: Sunil J. Sirdesai, George Schaeffer