Hydroxyl Containing Patents (Class 436/131)
  • Patent number: 7851221
    Abstract: The invention provides a system for designing, operating, monitoring and/or diagnosing a chemical reaction, particularly a hydrotreating process, using a fixed bed catalytic reactor.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: December 14, 2010
    Assignee: Exxonmobilchemical Patents Inc.
    Inventors: Ronald D. Garton, David G. Woods, Hans G. Korsten, Pierre J. Osterrieth, Brian C. McClaine
  • Publication number: 20100285603
    Abstract: The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.
    Type: Application
    Filed: December 3, 2008
    Publication date: November 11, 2010
    Inventors: Uwe Kobold, Thomas Duelffer, Michael Grol, Rupert Herrmann, Herbert Von der Eltz, Leopold Von Proff
  • Publication number: 20100273661
    Abstract: A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine.
    Type: Application
    Filed: June 11, 2008
    Publication date: October 28, 2010
    Applicants: SmithKline Beecham Corporation, BG Medicine Inc
    Inventors: Yang Qiu, Dilip Rajagopalan, Lei Zhu, Susan C Connor, Guanghui Hu, David Maclean, Doris Damian, Amir Handzel, Rajalakshmi Balasubramanian
  • Publication number: 20100267004
    Abstract: A method for labeling biological molecules and synthetic molecules that contain a geminal diol, such as RNA, carbohydrates or glycoproteins, using a periodate sequestering agent is provided. Compositions and kits for use in the labeling method are also provided.
    Type: Application
    Filed: October 31, 2008
    Publication date: October 21, 2010
    Applicant: BIOVENTURES, INC.
    Inventors: Elliott P. Dawson, Kristie E. Womble
  • Publication number: 20100255519
    Abstract: The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.
    Type: Application
    Filed: March 15, 2010
    Publication date: October 7, 2010
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Daniel H. Fine, David Furgang
  • Publication number: 20100248381
    Abstract: The present invention provides methods for detecting urushiol-bearing plants such as poison ivy, poison oak, and poison sumac. Accordingly, one aspect of the invention is a method of detecting a urushiol-bearing plant, the method comprising: dispensing a urushiol marking composition on a surface of the urushiol-bearing plant; then detecting a visual change on the urushiol-bearing plant caused by the reaction of the urushiol marking composition with the urushiol borne by the urushiol-bearing plant.
    Type: Application
    Filed: March 25, 2010
    Publication date: September 30, 2010
    Inventor: Alisha Hansen
  • Publication number: 20100233756
    Abstract: Kibble-type animal feeds and pet foods including a vegetable protein-based core matrix and a coating of a fat and at least one additive are described. The coating may include a probiotic enriched coating. Methods of forming the kibble-type animal feeds and pet foods are also described. Probiotic coating for a kibble showing acceptable stability and bioactivity are disclosed and methods for assessing the bioactivity of a probiotic in a food composition are also described.
    Type: Application
    Filed: September 9, 2009
    Publication date: September 16, 2010
    Inventors: Gregory Dean Sunvold, John Leslie Brent, JR., Patrick Joseph Corrigan, Michael Griffin Hayek
  • Publication number: 20100227412
    Abstract: Methods for determining the amounts of estrogen and non-estrogen steroids in a sample are provided. The methods employ the selective derivatization of estrogen steroids present in a sample and detection of the molecular ions and fragments of the derivatized estrogens and non-estrogen steroids in the sample. The methods provided herein enable the simultaneous quantification of estrogen and non-estrogen steroids in a sample.
    Type: Application
    Filed: February 5, 2010
    Publication date: September 9, 2010
    Applicant: PERKINELMER HEALTH SCIENCES, INC.
    Inventor: Blas Cerda
  • Publication number: 20100216128
    Abstract: The present invention generally relates methods for analyzing agricultural and/or environmental samples using liquid bridges. In certain embodiments, the invention provides a method for analyzing an agricultural sample for a desired trait including obtaining a gene or gene product from an agricultural sample, in which the gene or gene product is in a first fluid; providing a liquid bridge for mixing the gene or gene product with at least one reagent to form a mixed droplet that is wrapped in an immiscible second fluid; and analyzing the mixed droplet to detect a desired trait of the agricultural sample.
    Type: Application
    Filed: May 20, 2009
    Publication date: August 26, 2010
    Applicant: STOKES BIO LTD.
    Inventors: Mark Davies, Tara Dalton
  • Publication number: 20100197034
    Abstract: Used is a sample holder for MALDI mass spectrometry, which has a CuO secondary particle as a laser-beam-absorbing matrix and in which the secondary particle comprises an aggregate of CuO primary particles having an average particle diameter of 100 nm or smaller and has an uneven surface arising from the shape formed by the primary particles constituting the outermost surface of the secondary particle. As the CuO secondary particle, usable is one derived from a CuO powder produced by baking basic copper carbonate in air at 200 to 300° C., and the basic copper carbonate is produced in a process of mixing an aqueous ammonium hydrogencarbonate solution and an aqueous copper nitrate solution. The CuO secondary particle has an average particle diameter of, for example, from 0.3 to 10 ?m.
    Type: Application
    Filed: June 25, 2008
    Publication date: August 5, 2010
    Inventors: Tetsu Yonezawa, Kimitaka Sato
  • Publication number: 20100178707
    Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.
    Type: Application
    Filed: March 26, 2010
    Publication date: July 15, 2010
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Ravinder J. Singh, Robert L. Taylor, Stefan Grebe
  • Publication number: 20100173421
    Abstract: This invention relates to a sensor and in particular to a sensor for the detection of biologically important species. Specifically, the invention provides a method for detecting an analyte in the presence of at least one interferent in a sample. The method comprises the steps of providing a sensor having a transducer and a receptor layer in communication with the transducer, in which the receptor layer comprises a material for absorbing the analyte; exposing the receptor layer to the sample; treating the receptor layer to remove selectively the at least one interferent; and measuring the signal from the transducer. The treatment step is performed by applying a change in potential, a change in pH or a change in temperature to the receptor layer, by washing the receptor layer, by irradiating the receptor layer, or a combination thereof.
    Type: Application
    Filed: February 29, 2008
    Publication date: July 8, 2010
    Applicants: CRANFIELD UNIVERSITY, SPHERE MEDICAL LIMITED
    Inventors: Sergey Anatoliyovich Piletsky, Yves Frederic Henry, Khalku Karim, Peter Georg Laitenberger
  • Patent number: 7745226
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: June 29, 2010
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Brett Holmquist, Kwang-Ja Lee, Richard E. Reitz
  • Publication number: 20100152115
    Abstract: The present invention relates, in general, to methods for detecting the amount of a polymer on a protein using near-infrared spectroscopy. Measurement of the number of polymer moieties per protein molecule allows for production of molecules having a uniform number of polymer moieties, which is useful in the production of pharmaceutical compositions.
    Type: Application
    Filed: December 11, 2009
    Publication date: June 17, 2010
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Alfred Weber, Joris Hoefinghoff, Juergen Siekmann, Peter Turecek
  • Patent number: 7736902
    Abstract: The present invention provides a simple, highly sensitive, and highly precise method for determining the absolute configuration of a chiral compound such as a diamine or an amino alcohol. The present invention is directed to a method for determining the absolute configuration of an asymmetric carbon of a chiral compound on the basis of the sign of the Cotton effect by analyzing a solution containing the chiral compound and a porphyrin dimer by circular dichroism spectroscopy.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: June 15, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Yoshihisa Inoue, Victor V. Borovkov, Guy A. Hembury
  • Publication number: 20100136600
    Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.
    Type: Application
    Filed: April 14, 2008
    Publication date: June 3, 2010
    Inventors: Carolyn Slupsky, Thomas Marrie
  • Publication number: 20100129923
    Abstract: Embodiments of the present invention provide for detecting and/or screening for conditions associated with altered sterols by dehvatization of sterols to provide suitable sensitivity and selectivity of detection using tandem mass spectrometry with electrospray ionization. Such testing may be performed to detect and/or screen for conditions such as Smith-Lemli-Opitz syndrome, familial hypercholesterolemia, and cerebrotendinous xanthomatosis, or certain bile acid disorders.
    Type: Application
    Filed: May 2, 2008
    Publication date: May 27, 2010
    Applicant: Oregon Health & Science University
    Inventors: Andrea DeBarber, Robert D. Steiner
  • Publication number: 20100120159
    Abstract: Electrodeposition baths, systems and methods are provided. In some embodiments, the baths, systems and methods are used to deposit metal alloy coatings.
    Type: Application
    Filed: November 7, 2008
    Publication date: May 13, 2010
    Applicant: Xtalic Corporation
    Inventors: Alan C. Lund, Nazila Dadvand, John Cahalen, Daniel J. Montville
  • Patent number: 7704751
    Abstract: A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: April 27, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: Michael C. Palazzotto, Neal A. Rakow, Michael S. Wendland
  • Publication number: 20100093103
    Abstract: A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, whirling 3-5 mins, centrifugating at 9600 rpm for 10 mins, drying and enriching the upper layer at 25-30° C., and redissolving with mobile phase; (2) UPLC/MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C18, 2.1?100 mm, mobile phase A: water-acetonitrile-formic acid 95:5:0.1 v/v/v, mobile phase B: acetonitrile-formic acid 100:0.1 v/v; MS condition: electric spraying ion source(ESI), detecting with positive ion mode, scanning at the range of m/z 150-1200. The method can be used for pharmacokinetics study of schizadrin B in dissipating blood stasis botanical.
    Type: Application
    Filed: April 28, 2008
    Publication date: April 15, 2010
    Inventors: Yueming Ma, Rong Shi, Yongyu Zhang
  • Patent number: 7695973
    Abstract: The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein under conditions where both glycated and non-glycated protein bind to the support in making a second bound protein measurement under conditions where glycated protein is bound to the support and non-glycated protein is not substantially bound. Diagnostic devices and kits comprising the methods of the present invention are also provided.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: April 13, 2010
    Assignee: Scripps Laboratories, Inc.
    Inventors: Ralph P. McCroskey, Cameron E. Melton
  • Publication number: 20100087462
    Abstract: The invention describes methods and tools for the identification of drug intolerance into subjects receiving an hypolipidemic agent. The invention further describes methods and tools for the prediction of drug intolerance in subjects in need of hypolipidemic agents. Some aspects of the invention are based on the assessment of the subject plasma glycerol concentrations. Some aspects of the invention are based on the assessment of the subject HDL-triglycerides concentration. Some other aspects are based on the identification of hepatic lipase gene variants in a subject genome.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 8, 2010
    Applicant: BOREAL PHARMA RECHERCHE CLINIQUE
    Inventors: Daniel GAUDET, Marta SANTURE, Diane BRISSON, Gerald TREMBLAY
  • Publication number: 20100075432
    Abstract: This invention relates to a sensor and in particular to a sensor for the detection of biologically important species. Specifically, the invention provides a sensor for detecting an analyte in a sample.
    Type: Application
    Filed: February 29, 2008
    Publication date: March 25, 2010
    Inventors: Sergey Anatoliyovich Piletsky, Olivier Yves Frederic Henry, Khalku Karim, Peter Georg Laitenberger
  • Publication number: 20100055665
    Abstract: The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime, at two or more wavelengths, from a sample comprising said analyte and two or more different macrocyclic lanthanide (III) complexes, wherein each of said macrocyclic lanthanide (III) complexes comprises a different lanthanide ion but the same macrocyclic ligand, and using a ratio of emission intensities or emission lifetimes measured at two different wavelengths to calculate the amount of analyte in said sample.
    Type: Application
    Filed: July 11, 2007
    Publication date: March 4, 2010
    Inventors: David Parker, Robert Anthony Poole, Filip Kielar
  • Publication number: 20100022019
    Abstract: A method of monitoring breakthrough of an adsorbent bed consisting for example of ion-exchange resins, used during a stage of purification of an ester stream containing glycerin, obtained for example in a vegetable or animal oil and aliphatic monoalcohol transesterification process, permits the instantaneous detection of the presence of glycerol (glycerin) in the ester stream by arranging a turbidimeter at the adsorbent bed outlet.
    Type: Application
    Filed: July 20, 2009
    Publication date: January 28, 2010
    Applicant: IFP
    Inventors: Abdelhakim Koudil, Karin Barthelet, Laurent Bournay
  • Publication number: 20090318392
    Abstract: The invention concerns a method for diagnosing a child's susceptibility for developing type 1 diabetes by using a serum metabolite as biomarker. The invention concerns also a method for prevention of the onset of type 1 diabetes in a child.
    Type: Application
    Filed: September 10, 2007
    Publication date: December 24, 2009
    Applicant: ZORA BIOSCIENCES OY
    Inventors: Matej Oresic, Olli Simell, Tuulikki Seppänen-Laakso, Marko Sysi-Aho
  • Patent number: 7635595
    Abstract: The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2?1), arsenious acid, H3 AsO3 (or arsenite ion, H2AsO3?1), telluric acid, H6TeO6 (or tellurate ion, H5 TeO6?1) or germanic acid, Ge(OH)6 (or germanate ion, GeO(OH)3?1) are described. Method of using said probes are also provided.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: December 22, 2009
    Inventors: Joseph R. Lakowicz, Nicolas Dicesare
  • Publication number: 20090286322
    Abstract: Disclosed is a testing apparatus for detecting the presence of harmful substances in a fluid. The testing apparatus includes a base member and a flap member removably attached to the base member. Further, the testing apparatus includes at least one testing stick enclosed within the base member. The at least one testing stick includes an elongated member and a chemical reagent disposed on the elongated member. The chemical reagent is capable of reacting with the harmful substances. Such a reaction of the chemical agent with the harmful substances results in a change in a color of the chemical reagent indicating the presence of the harmful substances in the fluid. Further disclosed is a method for detecting the presence of the harmful substances in the fluid using the testing apparatus.
    Type: Application
    Filed: May 16, 2008
    Publication date: November 19, 2009
    Inventor: Donna Dancer
  • Patent number: 7618585
    Abstract: An ultrasonic wave passes different fuels of different concentrations with different velocities. The present invention provides a detecting and controlling device where, by a non-touching method, a velocity for an ultrasonic wave in a first fuel with a first fuel concentration is measured. The velocity obtained is taken for a comparison with another velocity for the same ultrasonic wave in a fuel with a default fuel concentration so that the first fuel concentration of the fuel can be under controlled.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: November 17, 2009
    Assignee: Atomic Energy Council - Institute of Nuclear Energy Research
    Inventors: Kang-Nang Perng, Ching-Shih Liu, Kin-Fu Lin, Charn-Ying Chen, Kang-Lin Hwang, Ying-Sheng Lee
  • Publication number: 20090186419
    Abstract: The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors.
    Type: Application
    Filed: January 20, 2006
    Publication date: July 23, 2009
    Applicant: Agency for Science ,Technology and Research
    Inventors: Jackie Y. Ying, Hsiao-Hua Yu, Emril Mohamed Ali
  • Publication number: 20090155766
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 18, 2009
    Inventors: Mildred M. Goldman, Nigel J. Clarke, Richard E. Reitz
  • Publication number: 20090130655
    Abstract: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead. The Raman spectra of the product formed by binding of the sensor bead and an analyte in a sample is detected for determining whether the analyte exists in the sample. In embodiment, the pH of the solution of metal nanoparticles is controlled to keep at 10, and the concentration of the Raman dye is controlled to keep between 1×10?6M and 2×10?6M for reducing the size of the nanoaggregate.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 21, 2009
    Applicant: NATIONAL CHUNG CHENG UNIVERSITY
    Inventors: Laikwan Chau, Tzyy-Schiuan Yang, Ping-Ji Huang, Tai-Tsung Lin
  • Patent number: 7531358
    Abstract: A method of quantifying an ethylene oxide based nonionic surfactant in a sample containing a physiologically active protein, characterized in that quantitation is performed by colorimetry, in particular, a method of quantifying an ethylene oxide based nonionic surfactant in a sample containing a physiologically active protein, characterized in that an ammonium thiocyanate/cobalt nitrate reagent (CoSCN reagent) is added to said sample solution and the resulting cobalt thiocyanate complex is quantified by absorbance measurement.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: May 12, 2009
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masaya Kakuta, Masahiko Tanikawa, Naoyoshi Kuroyanagi, Yoshiyuki Endo
  • Publication number: 20090062126
    Abstract: Compositions and methods for inhibiting the sprouting of potato tubers are provided. The compositions comprise C3 to C14 aliphatic aldehydes and ketones, and/or C3 to C7 primary and secondary aliphatic alcohols.
    Type: Application
    Filed: August 6, 2008
    Publication date: March 5, 2009
    Inventors: Norman Richard Knowles, Lisa O'Rear Knowles
  • Patent number: 7494816
    Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: February 24, 2009
    Assignees: Roche Diagnostic Operations, Inc., Roche Operations Ltd.
    Inventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
  • Publication number: 20080317835
    Abstract: Assays are preformed to determine nutrient deficiency levels in an individual to address the deficiencies and improve health and longevity. Nutraceutical and cosmeceutical products containing nanoencapsulated active ingredients are provided, in addition to dietary, exercise, sleep, and other lifestyle recommendations.
    Type: Application
    Filed: June 20, 2007
    Publication date: December 25, 2008
    Inventors: Nazli Azimi, Mohammad Saeed Kharazmi
  • Patent number: 7425453
    Abstract: A Fabry-Perot cavity has a pair of partially transmissive, partially reflective, surfaces. A first of the surfaces is flexibly suspended adjacent and parallel to a second of the surfaces. A gap exists between the surfaces. A variable electrostatic potential permits this gap to be adjusted. A translucent chemical layer is disposed on the first surface. A photosensor is attached to the second surface. Light irradiates the photosensor through the chemical layer and the first and second surfaces wherein the light is also partially reflected between the surfaces. A sensing environment is provided wherein an agent undergoes a reaction with the chemical layer as well as an environment wherein the reaction does not occur. The output of the photosensor is measured to assess a change in spectrum and spectral intensity for each of the sensing environments. The gap between the surfaces as well as the light used are selected to provide an optimum photosensor output.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: September 16, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Chris Hutchens, Richard L. Waters
  • Patent number: 7422904
    Abstract: The invention provides a system for designing, operating, monitoring and/or diagnosing a chemical reaction, particularly a hydrotreating process, using a fixed bed catalytic reactor.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: September 9, 2008
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Ronald D. Garton, David G. Woods, Hans G. Korsten, Pierre J. Osterrieth, Brian C. McClaine
  • Patent number: 7390669
    Abstract: The present invention is a rapid method of determining the concentration of the major components in a chemical stream. The present invention is also a simple, low cost, device of determining the in-situ concentration of the major components in a chemical stream. In particular, the present invention provides a useful method for simultaneously determining the concentrations of sodium hydroxide, sodium sulfide and sodium carbonate in aqueous kraft pulping liquors through use of an attenuated total reflectance (ATR) tunnel flow cell or optical probe capable of producing a ultraviolet absorbency spectrum over a wavelength of 190 to 300 nm. In addition, the present invention eliminates the need for manual sampling and dilution previously required to generate analyzable samples.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: June 24, 2008
    Assignee: Georgia Tech Research Corporation
    Inventors: Jian Li, Xin Sheng Chai, Junyoung Zhu
  • Publication number: 20080146675
    Abstract: Stable Atomoxetine hydrochloride, a process for the manufacture thereof, the use of stable Atomoxetine Hydrochloride for making a pharmaceutical formulation, a process for the preparation of any form of Atomoxetine Hydrochloride, and an analytical method for analyzing the stability of Atomoxetine Hydrochloride are provided.
    Type: Application
    Filed: February 15, 2008
    Publication date: June 19, 2008
    Inventors: Eugenio Castelli, Paolo Riva
  • Publication number: 20080138797
    Abstract: Detection systems and methods of their use are provided. An exemplary system comprises a chamber for holding culture media, the chamber having a cellular attachment surface, and a detector disposed in the chamber comprising a surface modified with a binding agent for binding a target substance wherein the detection system is configured to detect interaction of the target substance with the binding agent. The detection can occur in either liquid or vapor phase and the subsequent action of the system is to respond in a programmed and appropriate manner to the binding event by activation of a chemical or physical responder. The system may also respond by communicating information to a control system via an alarm.
    Type: Application
    Filed: November 15, 2004
    Publication date: June 12, 2008
    Inventors: William D. Hunt, John Cairney
  • Patent number: 7202090
    Abstract: To provide a hardness measurement reagent unaffected by an M alkalinity in hardness measurement. A hardness measurement reagent as a one-solution type reagent includes a dye chosen from Eriochrome Black T (EBT) and Calmagite, triethanolamine, a glycol compound, and a pH buffer, in which the pH buffer includes a combination of amines selected from primary amines and secondary amines and a salt of a weak base.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: April 10, 2007
    Assignee: Miura Co., Ltd.
    Inventor: Hiroyuki Mitsumoto
  • Patent number: 7195923
    Abstract: The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral flow test strip or vertical flow test strip devices having negatively charged carboxyl or carboxylate groups and hydroxyboryl groups immobilized and interspersed on a solid support matrix. The solid support matrix may include derivatives of cellulose (e.g., carboxy cellulose) derivatized with carboxylic acid (e.g., carboxylate, carboxyl) groups and hydroxyboryl compounds including phenylboronic acid (e.g., phenylborate), aminophenylboronic acid, boric acid (e.g., borate), or other boronic acid (e.g., boronate) compounds. The present invention is usefi.il for monitoring glycation or glycosylation of hemoglobin or albumin for monitoring glycemic control (e.g., glycemia in diabetes).
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: March 27, 2007
    Assignee: Scripps Laboratories, Inc.
    Inventors: Ralph P. McCroskey, Cameron E. Melton
  • Patent number: 7150997
    Abstract: A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: December 19, 2006
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 7125725
    Abstract: A novel achiral biaryl-type compound and a circular dichroism(CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chiral compound.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: October 24, 2006
    Assignee: Kanazawa University
    Inventors: Tomihisa Ohta, Shinzo Hosoi
  • Patent number: 7101717
    Abstract: An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each electrode of the array, the driven electrodes being driven at one of a plurality of stimulus levels by a source of electrical current or voltage external to the array.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: September 5, 2006
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 7081347
    Abstract: A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro-thromboxane B2 that falls within the second, third, or fourth quartile is indicative of aspirin resistance and an elevated risk of a recurrent cardiovascular event.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: July 25, 2006
    Assignee: McMaster University
    Inventors: Salim Yusuf, Jack Hirsh, John Eikelboom
  • Patent number: 7045097
    Abstract: A biologic electrode array is formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate. A matrix of optical detectors is disposed beneath the electrode sites in the semiconductor substrate, wherein each electrode site is associated with a corresponding optical detector. The optical detectors are coupled to detection circuitry formed on the semiconductor substrate. The electrode sites may include slitted electrodes, punctuated electrodes, or optically transparent electrodes.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: May 16, 2006
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 6867048
    Abstract: A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: March 15, 2005
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 6844196
    Abstract: The present invention relates to antioxidant analysis for solder plating solutions, by using a complexing solution comprising a molybdenum compound, such as MoO2Cl2, to form a highly colored antioxidant-molybdenum complex, which can be detected and analyzed by UV-Vis spectroscopic, as a basis for concentration determination for the antioxidant.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: January 18, 2005
    Assignee: Advanced Technology Materials, Inc.
    Inventors: Mackenzie E. King, Cory Schomburg, Monica K. Hilgarth