Optical Result Patents (Class 436/164)
  • Patent number: 9618479
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 11, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Patent number: 9598282
    Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, and a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance. The method measures at least one change in an electrical impedance between spatially separated electrodes, and identifies the chemical species based on the measured change in the electrical impedance.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 21, 2017
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Li Han, Anthony L. Andrady, David S. Ensor
  • Patent number: 9568462
    Abstract: A method of monitoring the evolution of polymer and/or colloid stimuli responsiveness during synthesis of polymers and/or colloids, including postpolymerization modifications on natural and synthetic polymers, includes providing a reactor in which the polymers and/or colloids are synthesized; and providing a means of monitoring the stimuli responsiveness of the polymers and/or colloids during said synthesis. Preferably, the method also includes monitoring the evolution of the characteristics of the polymers and/or colloids during said synthesis. Preferably, evolution of polymer and/or colloid stimuli responsiveness is correlated to the evolution of the properties of the polymers and/or colloids themselves. Also, preferably the conditions of the fluid in the reactor in which the synthesis occurs is determined. The determination can be by detection, choice of materials and temperature conditions, for example, and combinations thereof.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: February 14, 2017
    Assignee: The Administrators of the Tulane Educational Fund
    Inventor: Wayne F. Reed
  • Patent number: 9486179
    Abstract: A multilayered optical tissue phantom fabrication approach and inherently produced test target structure which address the issues of of optical conformity known in the art by controlling the formation of micrometer scale monolayers embedded with light-scattering microspheres.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: November 8, 2016
    Assignee: The United States of America, as represented by the Secretary of Commerce The National Institute of Standards and Technology
    Inventors: Jeeseong Hwang, Christopher Stafford, Robert Chang
  • Patent number: 9476856
    Abstract: A method of detecting a target analyte in a sample, including executing electrowetting-mediated droplet operations and thereby: combining one or more immunoassay reagent droplets comprising magnetically-responsive beads having affinity for the target analyte with one or more sample droplets potentially comprising the target analyte to yield a first combined droplet; beginning with the combined droplet, effecting a droplet-based washing protocol to wash the magnetically-responsive beads to yield a first washed droplet comprising the washed magnetically responsive beads; and combining the droplet comprising the washed magnetically responsive beads with a droplet comprising a reporter molecule having affinity for target analyte captured on the magnetically-responsive beads to yield a second combined droplet; beginning with the second combined droplet, effecting a droplet-based washing protocol to wash the magnetically-responsive beads to yield a second washed droplet comprising the washed magnetically responsive
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 25, 2016
    Assignees: ADVANCED LIQUID LOGIC, INC., DUKE UNIVERSITY
    Inventors: Vamsee K. Pamula, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair
  • Patent number: 9470572
    Abstract: A method of measuring a liquid level of a cell culture solution stored in a cell vessel, includes: irradiating the cell culture solution with at least two kinds of light beams including a first light beam having a first wavelength and a second light beam having a second wavelength; measuring a first absorbance of the cell culture solution with respect to the first light beam, and a second absorbance of the cell culture solution with respect to the second light beam; and determining a liquid level of the cell culture solution based on the first absorbance and the second absorbance.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 18, 2016
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Teruo Okano, Tatsuya Shimizu
  • Patent number: 9451913
    Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: September 27, 2016
    Assignee: TOUCHTEK LABS, LLC
    Inventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis
  • Patent number: 9428547
    Abstract: The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: August 30, 2016
    Assignee: DNA Electronics, Inc.
    Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
  • Patent number: 9423338
    Abstract: Methods and apparatus are disclosed for determining a substance in a fluid excreted/extracted from the body or spent dialysate, e.g., for determining a quality measure for the dialysis, such as the concentration of selected toxic substances, and/or for determining a removed total quantity of uremic toxins during a dialysis with a dialysis apparatus. A concentration of a substance in the fluid may be determined by: detecting, by an absorption sensor, a first extinction signal of the fluid at an analysis wavelength at a defined first pH value of the fluid; adjusting, by a pH adjusting device, a second pH value of the fluid which differs from the first pH value; detecting, by the absorption sensor, a second extinction signal of the fluid at the analysis wavelength at the second pH value; and processing/comparing the two extinction signals for the first and the second pH values and determining an absolute concentration of the substance dissolved in the fluid.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: August 23, 2016
    Assignee: B. BRAUN AVITUM AG
    Inventors: Miran Alic, Christof Strohhoefer, Waldemar Janik
  • Patent number: 9353342
    Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: May 31, 2016
    Assignee: EMD Millipore Corporation
    Inventors: Ju-Sung Paul Hung, Philip J. Lee, Amedeo J. Cappione, III
  • Patent number: 9347797
    Abstract: The invention relates to a sensor for measuring an environmental effect, comprising a sensor material having an internal stress, which sensor material is designed to at least partially relax under the influence of the environmental effect. The sensor further comprising a detection unit for indirectly or directly detecting said relaxation. The invention also relates to a waveguide, comprising a grating in at least a portion of the waveguide, which waveguide comprises a coating, the coating comprising a polymer that contains reversible crosslinks that can be broken by the environmental effect in such a way that the polymer changes shape. The invention further relates to a sensor system comprising a waveguide, a light source, and a photo-detector.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: May 24, 2016
    Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
    Inventor: Arjen Boersma
  • Patent number: 9341576
    Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: May 17, 2016
    Assignee: PLATYPUS TECHNOLOGIES, LLC
    Inventors: Bharat Acharya, Avijit Sen, Nicholas Abbott, Kurt Kupcho
  • Patent number: 9297801
    Abstract: The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.
    Type: Grant
    Filed: September 3, 2011
    Date of Patent: March 29, 2016
    Assignee: The Regents of the University of California
    Inventors: Jin Zhang, Adam Schwartzberg, Thaddeus Norman, Tammy Y. Oshiro, Christian D. Grant, Rebecca Sutphen, Leo Seballos, Yi Zhang, Claire Gu
  • Patent number: 9239284
    Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: January 19, 2016
    Assignee: Singulex, Inc.
    Inventor: Richard Livingston
  • Patent number: 9233394
    Abstract: Hydrophobic-core microcapsules and methods of their formation are provided. A hydrophobic-core microcapsule may include a shell that encapsulates a hydrophobic substance with a core substance, such as dye, corrosion indicator, corrosion inhibitor, and/or healing agent, dissolved or dispersed therein. The hydrophobic-core microcapsules may be formed from an emulsion having hydrophobic-phase droplets, e.g., containing the core substance and shell-forming compound, dispersed in a hydrophilic phase. The shells of the microcapsules may be capable of being broken down in response to being contacted by an alkali, e.g., produced during corrosion, contacting the shell.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: January 12, 2016
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Luz M. Calle, Wenyan Li, Jerry W. Buhrow, Scott T. Jolley
  • Patent number: 9228934
    Abstract: A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: January 5, 2016
    Assignee: PerkinsElmer Health Sciences, Inc.
    Inventors: Gregory Hanlon, Timothy Neal, Richard Edwards
  • Patent number: 9216392
    Abstract: System, including apparatus and methods, for forming an array of emulsions. The system may comprise a plate including an array of emulsion production units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The system also may comprise a vacuum or pressure source configured to be connected operatively to wells of the plate to form a pressure drop between the input wells and the output well of each unit that is capable of driving a first fluid and a second fluid from respective first and second input wells of such unit and through the droplet generator, for collection as an emulsion in the output well of such unit.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: December 22, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Benjamin Joseph Hindson, Kevin Dean Ness, Billy Wayne Colston, Jr., Fred Paul Milanovich, Donald Arthur Masquelier, Anthony Joseph Makarewicz, Jr.
  • Patent number: 9182406
    Abstract: A system for making molecules, and proteins in particular, suitable for detection by a surface-selective nonlinear optical technique. A first use of the invention is for determining a protein's structure in real space and real time. A second use of the invention is to detect a protein or its activity (conformational change). A third use of the invention is for drug screening. A further aspect of the present invention is measuring probe tilt angle orientation in an oriented protein.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: November 10, 2015
    Assignee: Biodesy, Inc.
    Inventor: Joshua S. Salafsky
  • Patent number: 9176251
    Abstract: Asphaltene content and its spatial distribution in a reservoir containing crude oil is an important factor in determining the potential for formation damage and pipeline impairment, as well as planning for processing and refining of the oil. Exemplary uses include: reservoir modeling, development and depletion planning, pressure maintenance, and surface facilities management. A convenient method has been developed which uses two-dimensional NMR techniques during a temperature and/or pressure cycle to quantify the asphaltene content of the crude oil without the need for extracting the oil from the reservoir rock. The technique can be applied to core, down-hole logs, or, a combination of both.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: November 3, 2015
    Assignees: Schlumberger Technology Corporation, Saudi Arabian Oil Company
    Inventors: Philip M. Singer, Patrice Ligneul, Edward Alan Clerke, Johannes J. M. Buiting
  • Patent number: 9176042
    Abstract: A microchip is provided which includes a first introduction channel, second introduction channels arranged to sandwich the first introduction channel and merged with the first introduction channel from both sides, and a merge channel connected to the first introduction channel and the second introduction channels, where fluids fed from the first and the second introduction channels are merged and flow, wherein the merge channel has a tapered portion formed so that a channel width in a sandwiching direction along which the first introduction channel is sandwiched by the second introduction channels gradually increases along a fluid feeding direction.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: November 3, 2015
    Assignee: SONY CORPORATION
    Inventors: Tatsumi Ito, Shoji Akiyama, Masaya Kakuta, Takeshi Yamasaki
  • Patent number: 9170132
    Abstract: A detachable, replaceable, and/or disposable probe head connectable to a probe body containing electronics, a probe that includes the probe head and the probe body, and the combination of a sonde and the probe are described herein. The probe head includes a housing that has a coupling member for detachably connecting the housing to the probe body, in particular to the electronics in the probe body. The probe head also includes a sensor and an electrical connector at least partially housed within the housing, and an operational amplifier electrically coupling the sensor to the electrical connector.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: October 27, 2015
    Assignee: YSI INCORPORATED
    Inventors: Christopher J. Palassis, Christopher M. Schuyler
  • Patent number: 9170208
    Abstract: Disclosed is a portable handheld characteristic analyzer used to analyze chemical compositions in or near real-time. One method of using the analyzer to determine a characteristic of a sample includes directing the handheld characteristic analyzer at the sample, the handheld characteristic analyzer having at least one integrated computational element arranged therein, activating the handheld characteristic analyzer, thereby optically interacting the at least one integrated computational element with the sample and generating optically interacted light, receiving the optically interacted light with at least one detector arranged within the handheld characteristic analyzer, generating an output signal corresponding to the characteristic of the sample with the at least one detector, receiving the output signal with a signal processor communicably coupled to the at least one detector, and determining the characteristic of the sample with the signal processor.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: October 27, 2015
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Ola Tunheim, Marshall E. Webster, Alexis Wachtel, II, Robert P. Freese, James R. MacLennan
  • Patent number: 9164087
    Abstract: An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can specifically bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The dried indicator reagent delivery unit comprises a label zone permeated with a dried indicator reagent which is capable of being placed in transient fluid communication with the reaction zone of the test unit during the assay procedure.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: October 20, 2015
    Assignee: MedMira Inc.
    Inventor: Hermes K. W. Chan
  • Patent number: 9149804
    Abstract: A microfluidic device includes at least two layers arranged one above the other, a membrane which is arranged between the at least two layers, a cavity in one of the at least two layers, and a channel in the other of the at least two layers. The membrane is arranged so as to be expandable between the cavity and the channel. The membrane is expandable into at least one specified displacement volume.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: October 6, 2015
    Assignee: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Patent number: 9150410
    Abstract: A device has a microelectromechanical system (MEMS) component with at least one surface and a coating disposed on at least a portion of the surface. The coating has a compound of the formula M(CnF2n+1Or), wherein M is a polar head group and wherein n?2r. The value of n may range from 2 to about 20, and the value of r may range from 1 to about 10. The value of n plus r may range from 3 to about 30, and a ratio of n:r may have a value of about 2:1 to about 20:1.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: October 6, 2015
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: William Robert Morrison, Mark Christopher Fisher, Murali Hanabe, Ganapathy Subramaniam Sivakumar, Simon Joshua Jacobs
  • Patent number: 9149807
    Abstract: A self-contained specimen testing unit consisting of a swab-tip with attached, hollow swab-stick, an outer, elongated, removable tube housing cover that surrounds and protects the swab-tip and swab-stick, a dropper removably secured to the end of the tube cover, a dropper cap, a piercing closure member, a rotatable base closure member coupled to the piercing closure element, a membrane member mounted in the base closure member, and reagent-solution storage container screwed onto the end of the rotatable base closure member and sealed by the membrane member thereof. A method of using the unit is also disclosed whereby the piercing unit pierces the membrane when reagent solution is to be delivered to the swab-tip.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: October 6, 2015
    Assignees: Berlin Packaging, LLC, Teclab Inc.
    Inventors: Brett Niggel, Scott Jost
  • Patent number: 9139786
    Abstract: A sensing device for sensing a substance includes a photonics integrated circuit having a resonator element that supports two different radiation modes, e.g. radiation modes of different polarisation, at a predetermined resonance wavelength. The resonator element is configured to convert a phase change or amplitude change experienced by the two different radiation modes upon formation of a layer of receptor molecules onto a sensing surface of the device into a resonance wavelength shift for the two different radiation modes. The sensing device also includes a detection unit arranged to detect the resonance wavelength shift for the two different radiation modes. The detection unit includes a processor that is configured to derive from the detected resonance wavelength shifts for the two different radiation modes, a layer thickness and refractive index of the layer of receptor molecules.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: September 22, 2015
    Assignees: UNIVERSITEIT GENT, IMEC
    Inventors: Peter Bienstman, Tom Claes, Katrien De Vos, Jan-Willem Hoste, Wim Bogaerts
  • Patent number: 9134247
    Abstract: A SERS method and apparatus employ a sample device having support structure including a first material containing a SER-active metal functionalized with a binding agent having specific capability for binding a designated target analyte. An analyte sample is introduced upon the functionalized SER-active metal; conditions to effect binding of the target analyte to the binding agent are maintained; unbound chemicals, biochemicals, or biologicals are removed; a second SER-active material is introduced to cause it to attach to the bound target analyte; the support structure is irradiated to generate a SER spectrum, with the first and second SER-active materials acting in concert; and the SER spectrum is detected and analyzed to determine the presence and quantity of the target analyte. Alternatively, the second SER-active material may be functionalized with a binding agent, with the procedure being modified accordingly.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 15, 2015
    Assignee: REAL-TIME ANALYZERS, INC.
    Inventors: Atanu Sengupta, Frank E. Inscore, Chetan Shende, Michael J. Donahue, Stuart Farquharson
  • Patent number: 9059355
    Abstract: A method of etching including providing a plurality of nanostructures extending away from a support, the support comprising a dielectric layer located between the plurality of nanowires, forming a patterned mask over a first portion of the plurality of nanostructures, such that a second portion of the plurality of nanostructures are exposed and are not located under the patterned mask, etching the second portion of the plurality of nanostructures to remove at least a portion of the patterned mask and the second portion of the plurality of nanostructures, monitoring at least one gaseous byproduct of the etching of the plurality of nanostructures during the etching of the plurality of nanostructures and stopping the etching on detecting that the dielectric layer is substantially removed.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: June 16, 2015
    Assignee: GLO AB
    Inventor: Daniel Bryce Thompson
  • Patent number: 9040307
    Abstract: Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: May 26, 2015
    Assignee: Blood Cell Storage, Inc.
    Inventors: Michael W. Reed, Steven J. Geelhood, Robert O. Dempcy
  • Patent number: 9040305
    Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: May 26, 2015
    Assignee: Singulex, Inc.
    Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
  • Patent number: 9040304
    Abstract: A multi-channel system and methods for sorting particles according to one or more characteristics of the particles. The system includes multiple flow cytometry units, each unit can have a nozzle for producing a fluid stream containing a desired population of particles in a mixture of particles. Each of the units may be operable to sort said desired population of particles by interrogating the fluid stream with a beam of electromagnetic radiation and classifying particles based on one or more characteristics of the particles. The system also includes a common fluid delivery system for delivering sheath fluid to each flow cytometer unit for producing respective fluid streams.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 26, 2015
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 9034652
    Abstract: Colloidal formulation for staining proteins and methods of their use are provided.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: May 19, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Christopher Belisle, Lee Olech, Thomas Berkelman, Praveena Garimella
  • Publication number: 20150132855
    Abstract: Techniques described herein enable a mobile multifunction device to detect a disposable sensor card at an interface coupled to the mobile multifunction device, wherein the disposable sensor card is mounted inside an opening in the mobile multifunction device, detect analog information associated with the disposable sensor card, and convert analog information to digital information. Detecting analog information comprises detecting a non-transient change in at least a portion of the disposable sensor card, wherein at least a portion of the first disposable sensor card changes form in response to exposure to one or more stimuli from an environment of the first disposable sensor card. A non-transient change may include one or more of changing color, changing shape, changing chemical composition or changing electrical characteristics. Furthermore, the interface may be configured to receive disposable sensor cards with varying sensing capabilities.
    Type: Application
    Filed: November 11, 2013
    Publication date: May 14, 2015
    Applicant: QUALCOMM Incorporated
    Inventors: Russel Allyn Martin, Ana Rangelova Londergan, Justin Phelps Black, Rihui He, Igor Tchertkov, Raghu Subramanian Srivatsa
  • Patent number: 9028757
    Abstract: A method for analysis of an object dyed with fluorescent coloring agents. Separately fluorescing visible molecules or nanoparticles are periodically formed in different object parts, the laser produces the oscillation thereof which is sufficient for recording the non-overlapping images of the molecules or nanoparticles and for decoloring already recorded fluorescent molecules, wherein tens of thousands of pictures of recorded individual molecule or nanoparticle images, in the form of stains having a diameter on the order of a fluorescent light wavelength multiplied by a microscope amplification, are processed by a computer for searching the coordinates of the stain centers and building the object image according to millions of calculated stain center co-ordinates corresponding to the co-ordinates of the individual fluorescent molecules or nanoparticles. Two-dimensional and three-dimensional images are provided for proteins, nucleic acids and lipids with different coloring agents.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: May 12, 2015
    Assignee: Super Resolution Technologies LLC
    Inventors: Andrey Alexeevich Klimov, Dmitry Andreevich Klimov, Evgeniy Andreevich Klimov, Tatiana Vitalyevna Klimova
  • Patent number: 9028770
    Abstract: This invention provides a cell made of polymers for spectra measurement while inhibiting a decrease in a molecular weight of resin caused by discharge treatment and having a stable hydrophilic modified surface. The hydrophilic resin cell is prepared by providing a polymeric resin cell between the two opposing electrodes, applying an electric field to a region between the above opposing electrodes under a nitrogen atmosphere with a pressure close to the atmospheric pressure to generate an electric discharge, and exposing the cell subjected to discharge treatment with a gas including oxygen.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 12, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Shinichi Taniguchi, Yukimune Takahashi, Takashi Inoue, Hiroaki Ishizawa
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9029473
    Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 12, 2015
    Assignee: University of Strathclyde
    Inventors: Peter Cormack, Duncan Graham, Aaron Hernandez-Santana, Arun Prasath Ramaswamy, William Ewen Smith
  • Patent number: 9023278
    Abstract: A device (600) for performing at least part of an analytical process comprises a communicator (605) to facilitate communication with the device, and a data handler (610) to handle data of the analytical process and/or the device. In an embodiment, the device (600) is a consumable device and/or a microfluidic device. A method for performing at least part of an analytical process using a device comprises the steps of: (a) introducing a sample into the device; (b) handling data associated with the test using a data handler of the device; and (c) facilitating communications about the test using a communicator of the device. In another embodiment, the method is performed using a consumable device and/or a microfluidic device.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: May 5, 2015
    Inventor: Micah James Atkin
  • Patent number: 9023660
    Abstract: Methods are disclosed for producing a bioweapon-sensitive fibrous-network product, wherein the subject products exhibit a color change in response to exposure to a biological agent (or portion thereof) as used in a biological weapon. Also disclosed are fibrous-network products that contain units of biopolymeric material that impart a color change to the products in response to exposure to a biological agent (or portion thereof) as used in a biological weapon.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: May 5, 2015
    Inventors: Dennis Farwell, Keith Baumann
  • Patent number: 9023652
    Abstract: The present invention relates to detectors for detecting fluorine-containing compounds and/or cyanide containing compounds, including hydrogen fluoride (HF) or HCN gas, hydrofluoric acid in solution, selected chemical warfare agents, selected industrial chemicals which may be hydrolyzed to release HF or HCN gas, compounds containing a cyanide group, and compounds that can release HF or HCN. The detectors comprise i) an organometallic component containing at least one bis-substituted boryl group of the formula —B(RB)(RB?) wherein each RB and each RB? is independently selected from H, halogen, C1-6 alkyl, OR6, N(R6)(R7), SR6, C3-20 aryl or heteroaryl, and C3-20 cycloalkyl or heterocycloalkyl groups, each of which may be optionally substituted, ii) a Lewis base component, and iii) a solid matrix component.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: May 5, 2015
    Assignee: University College Cardiff Consultants Ltd.
    Inventors: Simon Aldridge, Ian A. Fallis
  • Patent number: 9023281
    Abstract: Chemical indicator apparatuses containing one or more chemical indicators for use in monitoring the quality of water in an aquatic environment. The apparatuses are designed and configured to be submersible in the water that is being monitored. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo a physical change as levels of one or more constituents of the water change. Such indicators can be read by one or more suitable optical readers. These and other embodiments are designed and configured to be movable by a corresponding monitoring/measuring apparatus, for example, via a magnetically coupled drive. Also disclosed are a variety of features that can be used to provide a chemical indicator apparatus with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 5, 2015
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 9012228
    Abstract: Provided is a method for checking a blood status including: a step of supplying blood to the centrifugal container of a disk; a step of rotating the disk to centrifuge the blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifugal container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 21, 2015
    Assignee: Postech Academy-Industry Foundation
    Inventors: Dong Sung Kim, Moonwoo La, Sangmin Park
  • Patent number: 9012233
    Abstract: Provided is a water absorbing material having a granular core portion and a coating layer portion coating the granular core portion, which enables a test result after use to be clearly determined by developing vivid and uniform color. In the water absorbing material, the coating layer portion is composed of 90 wt % to 96 wt % of a substrate and 10 wt % to 4 wt % of an excretion test material, the excretion test material contains a porous adsorbent having an adsorbance of 20 wt % or greater and including micropores, and an excretion test indicator adsorbed on the micropores of the porous adsorbent, and the excretion test indicator is added in an amount more than 0.1 wt % and not more than 1.0 wt % relative to the total amount of the coating layer portion.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 21, 2015
    Assignee: Daiki Co., Ltd.
    Inventor: Hiroshi Ito
  • Publication number: 20150104815
    Abstract: Herein are provided nano-particles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering.
    Type: Application
    Filed: April 19, 2013
    Publication date: April 16, 2015
    Applicant: University Health Network
    Inventors: Gang Zheng, Natalie Tam
  • Patent number: 9005524
    Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 14, 2015
    Assignee: Nomadics, Inc.
    Inventors: Robert Deans, Aimee Rose, Kevin M. Bardon, Lawrence F. Hancock, Timothy M. Swager
  • Patent number: 8999652
    Abstract: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the cells determined along with identification of the cell by the barcode. Conveniently, surface marker proteins and labeled antibodies can be used to create the barcode and the cells analyzed with flow cytometry.
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: April 7, 2015
    Assignee: Primity Bio, Inc.
    Inventors: Peter Oliver Krutzik, Thomas Scott Wehrman
  • Patent number: 8999725
    Abstract: In one embodiment of the present application, a stimulus-responsive gel is disclosed with optical characteristic molecule introduced therein that is capable of easily and securely converting a volume change responding to external stimulus to optical data being easy to handle in the construction of sensor system; an external stimulus measuring apparatus making use of the same; and a method of measuring external stimulus therewith.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 7, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Takashi Miyata, Tadashi Uragami, Kaori Okawa
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia